PATENT DOCUMENT

Abstract:
A fungicidal composition having a synergistic effect is provided. The composition including active ingredients A and B. The active ingredient A is benziothiazolinone, the active ingredient B is one selected from benthiavalicarb-isopropyl, zoxamide, prothioconazole, boscalid, fenamidone, fluopicolide, famoxadone, pyraclostrobin, picoxystrobin or fluazinam, and the weight ratio of the two ingredients is from 1:50 to 50:1. The test results show that the fungicidal composition according to the present invention has an obvious synergistic effect, such that the application rate is reduced and the cost is lowered; and is useful in controlling certain particular fungal diseases on grain crops, vegetables, and fruits with a broadened fungicidal spectrum, a retarded resistance development of the fungi, and an improved control effect.

Full Description:
BACKGROUND 
       [0001]    1. Technical Field 
         [0002]    The present invention belongs to the field of agricultural plant protection, and particularly relates to a fungicidal composition with improved performances, and more particularly to a fungicidal composition comprising benziothiazolinone. 
         [0003]    2. Related Art 
         [0004]    Benziothiazolinone is a new broad-spectrum fungicide, which is mainly used for controlling and treating various bacterial and fungal diseases on cereal crops, vegetables, and fruits. The mechanisms of fungicidal action mainly include destroying the nuclei structure of the harmful fungi to cause they to die due to lose of the core component, and interfering with the metabolism of the fungal cells to cause physiological disturbance, thus ultimately leading to death. When the agent is used in the early stage of disease development, the plants may be effectively protected against infection of pathogens; and when the agent is used in an appropriately increased amount after the disease is developed, the spread of the harmful fungi is considerably controlled, thus achieving dual actions of protection and eradication. 
         [0005]    Benthiavalicarb-isopropyl has a strong preventive, curative, and penetration activity, and has a good persistence and rainfastness. In field trials, benthiavalicarb-isopropyl can effectively control the late blight of potatoes and tomatoes and the downy mildew of grape and other crops at a low application rate. When mixed with other fungicides, benthiavalicarb-isopropyl also has a quite good efficacy for harmful fungi. 
         [0006]    Zoxamide is a new broad-spectrum fungicide, which is mainly used for controlling and treating various bacterial and fungal diseases including downy mildew on cucumbers, black spot on pears, scab on apples, anthracnose on citrus, anthracnose on grapes, and others. The mechanisms of fungicidal action mainly include destroying the nuclei structure of the harmful fungi to cause they to die due to lose of the core component, and interfering with the metabolism of the fungal cells to cause physiological disturbance, thus ultimately leading to death. 
         [0007]    Prothioconazole is a new broad-spectrum triazolthione fungicide developed by Bayer Company, which is mainly used for controlling numerous diseases of cereals, wheat and barley, beans and other crops. Prothioconazole has a low toxicity, no teratogenicity and mutagenicity, and is non-toxic to embryos and safe for human and environment. The mechanism of action is inhibiting the demethylation at position 14 of lanosterol or 2,4-methylene dihydrolanosterol that is a precursor of sterol in fungi. 
         [0008]    Fenamidone has similar mechanism of action and features to those of famoxadone and methoxyacrylate fungicides, that is, through inhibition of the mitochondrial respiration by hindering the electron transfer at coenzyme Q for hydrogenation-cytochrome C oxidoreductase level. Fenamidone is applicable to wheat, cotton, grape, tobacco, turf, sunflower, rose, potato, tomato, and other vegetables for controlling various diseases including downy mildew, blight,  phytophthora  blight, damping-off, black spot, and mottled rot. 
         [0009]    Pyraclostrobin is a new broad-spectrum fungicide. The mechanism of action includes inhibition of the mitochondrial respiration by hindering the electron transfer during cytochrome synthesis. Pyraclostrobin has protective, curative, and leaf-penetrating translocation effects. The field efficacy test results show that the pyraclostrobin concentrate has a good control effect on powdery mildew and downy mildew of cucumber and black spot and leaf spot of bananas. 
         [0010]    Picoxystrobin is a systemic broad-spectrum fungicide, which is mainly used for controlling leaf diseases of wheat and barley, for example, leaf blight, leaf rust, glume blight, brown spot, and powdery mildew. Compared with other methoxyacrylate fungicides, picoxystrobin has a more potent curative effect for leaf blight, net blotch, and leaf blotch of wheat. 
         [0011]    Fluazinam is a 2,6-dinitroaniline protective fungicide, which can control the disease caused by  Botrytis cinerea  when applied at a dosage of 50-100 g (a.i.)/100 L. Fluazinam is quite effective for  Alternaria  spp,  Botrytis  spp,  Phytophthora  spp,  Plasmopara  spp,  Sclerotinia  spp, and  Nigrospora  spp, is highly effective for  Botrytis cinerea  resistant to benzimidazole and dicarboximide fungicides, and has long persistence and good rainfastness. Moreover, fluazinam also has a good control effect for phytophagous mites, crucifer club root, and rice damping-off caused by  Rhizopus  spp. 
         [0012]    Boscalid is a new nicotinamide fungicide, which is broad in fungicidal spectrum, active for almost all the types of harmful fungi, highly effective for controlling powdery mildew, grey mold, selerotium blight and various rots, and effective for fungi resistant to other agents. Boscalid is mainly used for controlling harmful fungi on rape, grape, fruit trees, vegetables and field crops. 
         [0013]    Fluopicolide has a prominent control effect on downy mildew, blight, late blight, damping-off and other common diseases caused by fungi from Oomycetes, is safe for crops and environment, and particularly useful in production of high-quality and green vegetables. Fluopicolide has a highly potent protective and curative effect for diseases on vegetables caused by fungi from Oomycetes due to its unique formulation. Fluopicolide has excellent systemic translocation performance and high thin layer penetrating ability, and has potent inhibition on all the major morphologies of the pathogens, thus providing full and persistent protection for young leaves, stems, tubers, and young fruits. Because fluopicolide can be absorbed quickly through the leaf surface, it has a good rainfastness, thus provide a reliable safeguard for disease control of vegetables in the rain season. 
         [0014]    Famoxadone is a new high-potent and broad-spectrum fungicidal agent, which is suitably used for wheat, barley, peas, sugar beets, rape, grape, potato, melons, hot peppers, tomato, and other crops, and mainly used for controlling diseases caused by fungi from Ascomycetes, Basidiomycetes, and Oomycetes, for example, powdery mildew, rust, glume blight, net blotch, downy mildew, and late blight. 
         [0015]    It is showed in practical use of pesticides that the repeated and exclusive application of one active compound to control the harmful fungi will result in the occurrence of rapid selectivity of the fungus strain in most cases. At present, the harmful fungi are controlled by using mixtures of compounds with different activities for the purpose of reducing the hazard of the selectivity of the resistant fungus strain. By combining active compounds having different mechanisms of action, the resistance development can be slowed down, the application rate is reduced, and thus the control cost is lowered. 
       SUMMARY 
       [0016]    In view of the technical problems above of resistance and persistence in soil of the fungicides in practical use, two fungicides of different mechanisms of fungicidal action are screened out and combined, to improve the control effect of the fungicides, retard the resistance development, reduce the application rate, and lower the control cost. 
         [0017]    To solve the above technical problems, the present invention provides a fungicidal composition. The composition comprises active ingredients A and B. The active ingredient A is benziothiazolinone, the active ingredient B is one selected from benthiavalicarb-isopropyl, zoxamide, prothioconazole, boscalid, fenamidone, fluopicolide, famoxadone, pyraclostrobin, picoxystrobin or fluazinam. The inventors find through tests that the fungicidal composition has an obvious synergistic effect, and importantly, the application rate is reduced, such that the cost is lowered. The ingredients A and B have different chemical structures and distinct mechanisms of action, by which the fungicidal spectrum can be broadened and the occurrence and development rate of resistance of the pathogens can be delayed to some extent when combined. Moreover, the ingredients A and B have no cross resistance. 
         [0018]    In the fungicidal composition, the weight ratio of the ingredient A to the ingredient B is from 1:50-50:1, and preferably 1:30-30:1, and more preferably 1:20-20:1 or 1:10-30:1 and most preferably 1:10-10:1 to achieve a much significant synergistic effect. 
         [0019]    The fungicidal composition according to the present invention comprises 5-85% by weight of the active ingredient and 95-15% by weight of pesticide adjuvants. Further, the composition is prepared into pesticidally acceptable formations with the active ingredients and the pesticide adjuvants. 
         [0020]    The present invention provides use of the fungicidal composition comprising the ingredient A (benziothiazolinone) and the ingredient B (benthiavalicarb-isopropyl, zoxamide, prothioconazole, boscalid, fenamidone, fluopicolide, famoxadone, pyraclostrobin, picoxystrobin, or fluazinam) in the control of diseases on crops in the agricultural area. 
         [0021]    When used in controlling the diseases on crops, the fungicidal composition of the present invention may be optionally used for seed impregnation, sprayed onto the leaves by reconstitution with water during the growth period of the crops, or applied onto the surface of the target objects, depending on the different diseases to be controlled. 
         [0022]    The composition may further comprise a carrier, an adjuvant and/or a surfactant. A commonly used adjuvant may be blended during application. 
         [0023]    The suitable adjuvant may be a solid or liquid that is generally a material commonly used in the preparation of formulations, for example, a natural or regenerated mineral substance, a solvent, a dispersing agent, a wetting agent, an adhesive, a thickener, a binder or a fertilizer. 
         [0024]    The composition of the present invention may be applied by administering the composition of the present invention to the aboveground parts of plants, in particular to the leaves or leaf surface thereof. The application frequency and rate depend on the pathogen biology and the climatic and maintenance conditions. The locus where the plant is growing, for example paddy field, may be impregnated with a liquid formulation of the composition, or the composition is incorporated in solid form into the soil, for example, in granular form (soil application) or penetrates the plant through the roots via the soil (systemic action). Alternatively, the occurrence of diseases may be eradicated and prevented by coating or immersing the seeds. 
         [0025]    The composition may be used by applying the active ingredients alone or in admixture with additives. 
         [0026]    The composition of the present invention may be prepared into various formulations, for example, a wettable powder, a suspension, an oily suspension, water dispersible granules, an aqueous emulsion, or a microemulsion. Depending on the properties of the compositions, the objectives intended to be achieved by applying the compositions, and the environmental conditions, the compositions may be applied by spraying, atomizing, dusting, scattering, or pouring. 
         [0027]    The composition of the present invention may be prepared into various formulations through known processes. The active ingredients may be uniformly mixed with an adjuvant such as a solvent or a solid carrier and a surfactant if needed, and ground to prepare a desired formulation. 
         [0028]    The solvent may be selected from aromatic hydrocarbons containing preferably 8 to 12 carbon atoms, for example, a xylene mixture, substituted benzene, or a phthalate ester, for example, dibutyl or dioctyl phthalate; aliphatic hydrocarbons, for example, cyclohexane or paraffin; alcohols, glycols and ethers and esters thereof, for example, ethanol, ethylene glycol, and ethylene glycol monomethyl ether; ketones, for example, cyclohexanone; high-polarity solvents, for example, N-methyl-2-pyrrolidone, dimethyl sulfoxide, or dimethyl formamide; and vegetable oils, for example, soy bean oil. 
         [0029]    The solid carrier includes for example natural mineral fillers generally used for powders and dispersible powders, for example, talc, kaolin, montmorillonite or activated bauxite. To manage the physical properties of the composition, highly dispersive silicic acid or highly dispersive absorbent polymer carrier may also be added, for example, granular adsorptive carrier or non-adsorptive carrier. The suitable granular adsorptive carrier is porous, for example, pumice, soapy clay or bentonite. The suitable non-adsorptive carrier includes for example calcite or sand. Moreover, a large amount of inorganic or organic material that is pre-prepared into granules and especially dolomite may be used as the carrier. 
         [0030]    As desired by the chemical nature of the active ingredients in the composition according to the present invention, the suitable surfactant includes ligninsulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkylsulfates, alkylsulfonates, fatty alcohol sulfates, fatty acids and ethylene glycol sulfated fatty alcohol ethers, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octyl phenyl ethers, ethoxylated iso-octylphenol, octylphenol, nonylphenol, alkylaryl polyethylene glycol ethers, tributylphenyl polyethylene glycol ether, tristearylphenyl polyethylene glycol ether, alkylaryl polyether alcohols, ethoxylated castor oil, polyoxyethylene alkyl ethers, condensation products of ethylene oxide, ethoxylated polyoxypropylene, polyethylene glycol ether laurate acetal, sorbates, waste lignin sulfite liquor, and methyl cellulose. 
         [0031]    The two active ingredients in the fungicidal composition of the present invention have a synergistic effect, such that the activity of the composition is obviously higher than the respective activity or expected sum of the respective activity of single compounds alone. The synergistic effect leads to a reduced application rate, a broadened fungicidal spectrum, fast onset of action, and a prolonged control effect, whereby the fungi harmful to plants can be well controlled only by means of one or several applications, and the underlying application interval is widened. In this application, the above effect is further confirmed through examples of control tests on grape downy mildew, wheat rust, potato late blight, wheat powdery mildew, tomato grey mold, and grape anthracnose respectively. These features are particularly important in practice of controlling the fungi harmful to plants. 
         [0032]    The fungicidal composition of the present invention exhibits the following additional features. 1. The composition of the present invention has an obvious synergistic effect. 2. Because the two individual agents in the composition of the present invention have highly different structures and completely different mechanisms of action, no cross resistance exists, such that the problem of resistance development occurred due to the use of single agents alone can be retarded. 3. The composition of the present invention is safe for crops, and good in the control effect. It is demonstrated through tests that the fungicidal composition of the present invention has stable chemical properties and a significant synergistic effect since the two active ingredients therein exhibit an obvious synergistic and complementary effect on the target organisms. 
     
    
     DETAILED DESCRIPTION 
       [0033]    To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is described in further detail with reference to examples. It should be understood that specific examples described herein are merely provided for explaining, instead of limiting the present invention. Any modifications, equivalent replacements, and improvements made without departing from the spirit and principle of the present invention fall within the protection scope of the present invention. 
         [0034]    The percentages given in all the formulations in the examples below are all weight percentages. The various formulations are processed from the composition of the present invention by a process known in the prior art which may be varied as desired. 
       I. Preparation Example of Formulations 
       [0035]    The formulations processed from the fungicidal composition of the present invention are those known in the prior art. For intuitively and clearly show the synergistic effect between the active ingredients of the present invention, only the wettable powder is optionally prepared in the preparation examples of formulations and used as the pesticide formulation to validate the synergistic effect between the active ingredients. 
         [0036]    The active ingredients benziothiazolinone and one of benthiavalicarb-isopropyl, zoxamide, prothioconazole, boscalid, fenamidone, fluopicolide, famoxadone, pyraclostrobin, picoxystrobin or fluazinam were fully mixed with various adjuvants and fillers in proportion, and ground by an ultra-fine grinder, to obtain a wettable powder. 
       Example 1 
     62% Benziothiazolinone•Benthiavalicarb-Isopropyl Wettable Powder 
       [0037]    benziothiazolinone 60%, benthiavalicarb-isopropyl 2%, a sodium alkyl naphthalene sulfonate 4%, sodium dodecyl sulfonate 3%, ammonium sulfate 3%, and light calcium carbonate q.s. to 100%. 
       Example 2 
     50% Benziothiazolinone•Benthiavalicarb-Isopropyl Wettable Powder 
       [0038]    benziothiazolinone 25%, benthiavalicarb-isopropyl 25%, sodium lignin sulfonate 6%, sodium dodecyl sulfonate 3%, xanthan gum 1%, sodium carboxymethyl starch 1%, and attapulgite clay q.s. to 100%. 
       Example 3 
     65% Benziothiazolinone•Benthiavalicarb-Isopropyl Wettable Powder 
       [0039]    benziothiazolinone 2%, benthiavalicarb-isopropyl 63%, sodium lignin sulfonate 5%, a sodium methylnaphthalene sulfonate formaldehyde condensate 7%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100% 
       Example 4 
     85% Benziothiazolinone•Zoxamide Wettable Powder 
       [0040]    benziothiazolinone 83%, zoxamide 2%, ammonium sulfate 1%, sodium alginate 2%, a sodium methylnaphthalene sulfonate formaldehyde condensate 1%, organic silicone 1%, and bentonite q.s. to 100% 
       Example 5 
     30% Benziothiazolinone•Zoxamide Wettable Powder 
       [0041]    benziothiazolinone 15%, zoxamide 15%, sodium dodecyl sulfonate 2%, a sodium alkyl naphthalene sulfonate 2%, ammonium sulfate 3%, and light calcium carbonate q.s. to 100%. 
       Example 6 
     75% Benziothiazolinone•Zoxamide Wettable Powder 
       [0042]    benziothiazolinone 2%, zoxamide 73%, a sodium methylnaphthalene sulfonate formaldehyde condensate 5%, sodium lignin sulfonate 4%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100%. 
       Example 7 
     62% Benziothiazolinone•Prothioconazole Wettable Powder 
       [0043]    benziothiazolinone 60%, prothioconazole 2%, sodium carboxymethyl starch 1%, sodium dodecyl sulfonate 4%, sodium lignin sulfonate 4%, xanthan gum 1%, and attapulgite clay q.s. to 100%. 
       Example 8 
     40% Benziothiazolinone•Prothioconazole Wettable Powder 
       [0044]    benziothiazolinone 20%, prothioconazole 20%, ammonium sulfate 1%, sodium alginate 2%, a sodium methylnaphthalene sulfonate formaldehyde condensate 1%, organic silicone 1%, and bentonite q.s. to 100%. 
       Example 9 
     65% Benziothiazolinone•Prothioconazole Wettable Powder 
       [0045]    benziothiazolinone 2%, prothioconazole 63%, a sodium methylnaphthalene sulfonate formaldehyde condensate 5%, sodium lignin sulfonate 4%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100%. 
       Example 10 
     65% Benziothiazolinone•Boscalid Wettable Powder 
       [0046]    benziothiazolinone 63%, boscalid 2%, calcium lignin sulfonate 2%, sodium dodecylbenzene sulfonate 1%, bentonite 2%, and attapulgite clay q.s. to 100%. 
       Example 11 
     60% Benziothiazolinone•Boscalid Wettable Powder 
       [0047]    benziothiazolinone 30%, boscalid 30%, an alkylpolyoxyethylene ether sulfonate 1%, nekal 2%, bentonite 1.5%, white carbon black 2%, and diatomaceous earth q.s. to 100%. 
       Example 12 
     62% Benziothiazolinone•Boscalid Wettable Powder 
       [0048]    benziothiazolinone 2%, boscalid 60%, a sodium alkylsulfonate 6%, sodium lignin sulfonate 6%, white carbon black 5%, and kaolin q.s. to 100%. 
       Example 13 
     62% Benziothiazolinone•Fenamidone Wettable Powder 
       [0049]    benziothiazolinone 60%, fenamidone 2%, a polyoxyethylene octyl phenyl ether 2%, sodium lignin sulfonate 6%, white carbon black 4%, and diatomaceous earth q.s. to 100%. 
       Example 14 
     50% Benziothiazolinone•Fenamidone Wettable Powder 
       [0050]    benziothiazolinone 25%, fenamidone 25%, calcium lignin sulfonate 7%, white carbon black 5%, sodium dodecylbenzene sulfonate 3%, and attapulgite clay q.s. to 100%. 
       Example 15 
     62% Benziothiazolinone•Fenamidone Wettable Powder 
       [0051]    benziothiazolinone 2%, fenamidone 60%, calcium lignin sulfonate 5%, bentonite 4%, a polyoxyethylene octyl phenyl ether 3%, and attapulgite clay q.s. to 100%. 
       Example 16 
     65% Benziothiazolinone•Fluopicolide Wettable Powder 
       [0052]    benziothiazolinone 63%, fluopicolide 2%, a polyoxyethylene octyl phenyl ether 1%, sodium lignin sulfonate 2%, white carbon black 3%, and diatomaceous earth q.s. to 100%. 
       Example 17 
     50% Benziothiazolinone•Fluopicolide Wettable Powder 
       [0053]    benziothiazolinone 25%, fluopicolide 25%, sodium dodecylbenzene sulfonate 3%, white carbon black 5%, calcium lignin sulfonate 7%, and attapulgite clay q.s. to 100%. 
       Example 18 
     65% Benziothiazolinone•Fluopicolide Wettable Powder 
       [0054]    benziothiazolinone 3%, fluopicolide 62%, calcium lignin sulfonate 5%, bentonite 4%, a polyoxyethylene octyl phenyl ether 3%, and attapulgite clay q.s. to 100%. 
       Example 19 
     60% Benziothiazolinone•Famoxadone Wettable Powder 
       [0055]    benziothiazolinone 58%, famoxadone 2%, sodium dodecylbenzene sulfonate 2%, bentonite 1%, calcium lignin sulfonate 2%, and attapulgite clay q.s. to 100%. 
       Example 20 
     50% Benziothiazolinone•Famoxadone Wettable Powder 
       [0056]    benziothiazolinone 25%, famoxadone 25%, sodium lignin sulfonate 6%, an alkylsulfonate 6%, white carbon black 11%, and kaolin q.s. to 100%. 
       Example 21 
     60% Benziothiazolinone•Famoxadone Wettable Powder 
       [0057]    benziothiazolinone 2%, famoxadone 58%, nekal 1%, an alkylpolyoxyethylene ether sulfonate 2%, bentonite 1.5%, white carbon black 2%, and diatomaceous earth q.s. to 100%. 
       Example 22 
     62% Benziothiazolinone•Pyraclostrobin Wettable Powder 
       [0058]    benziothiazolinone 60%, pyraclostrobin 2%, a sodium alkyl naphthalene sulfonate 4%, sodium dodecyl sulfonate 3%, ammonium sulfate 3%, and light calcium carbonate q.s. to 100%. 
       Example 23 
     50% Benziothiazolinone•Pyraclostrobin Wettable Powder 
       [0059]    benziothiazolinone 25%, pyraclostrobin 25%, sodium lignin sulfonate 6%, sodium dodecyl sulfonate 3%, xanthan gum 1%, sodium carboxymethyl starch 1%, and attapulgite clay q.s. to 100%. 
       Example 24 
     65% Benziothiazolinone•Pyraclostrobin Wettable Powder 
       [0060]    benziothiazolinone 2%, pyraclostrobin 63%, sodium lignin sulfonate 5%, a sodium methylnaphthalene sulfonate formaldehyde condensate 7%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100%. 
       Example 25 
     65% Benziothiazolinone•Picoxystrobin Wettable Powder 
       [0061]    benziothiazolinone 63%, picoxystrobin 2%, sodium alginate 3%, ammonium sulfate 2%, a sodium methylnaphthalene sulfonate formaldehyde condensate 1%, organic silicone 1%, and bentonite q.s. to 100%. 
       Example 26 
     30% Benziothiazolinone•Picoxystrobin Wettable Powder 
       [0062]    benziothiazolinone 15%, picoxystrobin 15%, sodium dodecyl sulfonate 2%, a sodium alkyl naphthalene sulfonate 2%, ammonium sulfate 3%, and light calcium carbonate q.s. to 100%. 
       Example 27 
     75% Benziothiazolinone•Picoxystrobin Wettable Powder 
       [0063]    benziothiazolinone 2%, picoxystrobin 73%, a sodium methylnaphthalene sulfonate formaldehyde condensate 5%, sodium lignin sulfonate 4%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100%. 
       Example 28 
     62% Benziothiazolinone•Fluazinam Wettable Powder 
       [0064]    benziothiazolinone 60%, fluazinam 2%, ammonium sulfate 3%, sodium carboxymethyl starch 1%, sodium dodecyl sulfonate 4%, sodium lignin sulfonate 4%, xanthan gum 1%, and attapulgite clay q.s. to 100%. 
       Example 29 
     40% Benziothiazolinone•Fluazinam Wettable Powder 
       [0065]    benziothiazolinone 20%, fluazinam 20%, ammonium sulfate 1%, sodium alginate 2%, a sodium methylnaphthalene sulfonate formaldehyde condensate 1%, organic silicone 1%, and bentonite q.s. to 100%. 
       Example 30 
     75% Benziothiazolinone•Fluazinam Wettable Powder 
       [0066]    benziothiazolinone 2%, fluazinam 73%, a sodium methylnaphthalene sulfonate formaldehyde condensate 5%, sodium lignin sulfonate 4%, sodium dodecyl sulfate 3%, and diatomaceous earth q.s. to 100%. 
       II. Efficacy Test 
     (I) Bioassay Examples 
       [0067]    1. Toxicity test of benziothiazolinone combined respectively with benthiavalicarb-isopropyl, zoxamide, prothioconazole, boscalid, fenamidone, fluopicolide, famoxadone, pyraclostrobin, picoxystrobin, and fluazinam on downy mildew pathogens of grape 
         [0068]    Test target organisms: downy mildew pathogens of grape 
         [0069]    Based on the test grade scale, the disease development on the leaves of the whole grape plant was investigated, and the disease index and control effect were calculated. 
         [0070]    The control effect was converted into probability (y), the concentration of the agents (μg/ml) in solution was converted into a logarithmic value (x), the toxic regression equation and the median inhibition concentration EC50 were calculated by least square method, and the toxicity index and the co-toxicity coefficient (CTC) of the agents were calculated by SUN Peiyun method. 
         [0000]      Actual toxicity index (ATI)=( EC 50 of standard/ EC 50 of test agent)*100 
         [0000]      Theoretical toxicity index (TTI)=toxicity index of agent  A *percentage content of  A  in the mixture+toxicity index of agent  B *percentage content of  B  in the mixture 
         [0000]      Co-toxicity coefficient (CTC)=[actual toxicity index (ATI) of the mixture/theoretical toxicity index (TTI) of the mixture]*100 
         [0071]    Where CTC≦80, the composition exhibits an antagonistic effect; where 80&lt;CTC&lt;120, the composition exhibits an additive effect, and where CTC≧120, the composition exhibits a synergistic effect. 
         [0072]    (1) Toxicity Test of Benziothiazolinone Combined with Benthiavalicarb-Isopropyl on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 benthiavalicarb-isopropyl on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 8.92 
                 100 
                 / 
                 / 
               
               
                 Benthiavalicarb-isopropyl 
                 10.75 
                 82.98 
                 / 
                 / 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 8.12 
                 109.85 
                 99.666 
                 110.218 
               
               
                 isopropyl = 50:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 7.28 
                 122.53 
                 99.451 
                 123.206 
               
               
                 isopropyl = 30:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 6.32 
                 141.14 
                 98.452 
                 143.359 
               
               
                 isopropyl = 10:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.83 
                 153 
                 91.488 
                 167.235 
               
               
                 isopropyl = 1:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.69 
                 156.77 
                 84.524 
                 185.474 
               
               
                 isopropyl = 1:10 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 8.48 
                 105.19 
                 83.526 
                 125.937 
               
               
                 isopropyl = 1:30 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 9.31 
                 95.81 
                 83.311 
                 115.003 
               
               
                 isopropyl = 1:50 
               
               
                   
               
             
          
         
       
     
         [0073]    The results (in Table 1) show that the control effect of the combination of benziothiazolinone with benthiavalicarb-isopropyl on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0074]    (2) Toxicity Test of Benziothiazolinone Combined with Zoxamide on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with zoxamide on 
               
               
                 downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 9.41 
                 100 
                 / 
                 / 
               
               
                 Zoxamide 
                 11.49 
                 81.9 
                 / 
                 / 
               
               
                 Benziothiazolinone:zoxamide = 50:1 
                 9.16 
                 102.73 
                 99.645 
                 103.096 
               
               
                 Benziothiazolinone:zoxamide = 30:1 
                 7.63 
                 123.33 
                 99.416 
                 124.054 
               
               
                 Benziothiazolinone:zoxamide = 10:1 
                 6.51 
                 144.55 
                 98.354 
                 146.969 
               
               
                 Benziothiazolinone:zoxamide = 1:1 
                 5.59 
                 168.34 
                 90.949 
                 185.093 
               
               
                 Benziothiazolinone:zoxamide = 1:10 
                 5.93 
                 158.68 
                 83.543 
                 189.938 
               
               
                 Benziothiazolinone:zoxamide = 1:30 
                 9.22 
                 102.06 
                 82.481 
                 123.738 
               
               
                 Benziothiazolinone:zoxamide = 1:50 
                 10.15 
                 92.71 
                 82.252 
                 112.715 
               
               
                   
               
             
          
         
       
     
         [0075]    The results (in Table 2) show that the control effect of the combination of benziothiazolinone with zoxamide on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0076]    (3) Toxicity Test of Benziothiazolinone Combined with Prothioconazole on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 prothioconazole on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 10.05 
                 100 
                 / 
                 / 
               
               
                 Prothioconazole 
                 13.26 
                 75.79 
                 / 
                 / 
               
               
                 Benziothiazolinone:prothioconazole = 50:1 
                 9.51 
                 105.68 
                 99.525 
                 106.184 
               
               
                 Benziothiazolinone:prothioconazole = 30:1 
                 8.42 
                 119.36 
                 99.219 
                 120.300 
               
               
                 Benziothiazolinone:prothioconazole = 10:1 
                 6.85 
                 146.72 
                 97.799 
                 150.022 
               
               
                 Benziothiazolinone:prothioconazole = 1:1 
                 7.19 
                 139.78 
                 87.896 
                 159.029 
               
               
                 Benziothiazolinone:prothioconazole = 1:10 
                 7.95 
                 126.42 
                 77.993 
                 162.091 
               
               
                 Benziothiazolinone:prothioconazole = 1:30 
                 10.82 
                 92.88 
                 76.573 
                 121.296 
               
               
                 Benziothiazolinone:prothioconazole = 1:50 
                 12.15 
                 82.72 
                 76.267 
                 108.461 
               
               
                   
               
             
          
         
       
     
         [0077]    The results (in Table 3) show that the control effect of the combination of benziothiazolinone with prothioconazole on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0078]    (4) Toxicity Test of Benziothiazolinone Combined with Boscalid on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with boscalid on 
               
               
                 downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 9.46 
                 100 
                 / 
                 / 
               
               
                 Boscalid 
                 11.61 
                 81.48 
                 / 
                 / 
               
               
                 Benziothiazolinone:boscalid = 50:1 
                 9.12 
                 103.73 
                 99.637 
                 104.108 
               
               
                 Benziothiazolinone:boscalid = 30:1 
                 7.86 
                 120.36 
                 99.403 
                 121.083 
               
               
                 Benziothiazolinone:boscalid = 10:1 
                 6.82 
                 138.71 
                 98.316 
                 141.086 
               
               
                 Benziothiazolinone:boscalid = 1:1 
                 6.87 
                 137.7 
                 90.741 
                 151.751 
               
               
                 Benziothiazolinone:boscalid = 1:10 
                 7.83 
                 120.82 
                 83.165 
                 145.277 
               
               
                 Benziothiazolinone:boscalid = 1:30 
                 9.51 
                 99.47 
                 82.079 
                 121.188 
               
               
                 Benziothiazolinone:boscalid = 1:50 
                 10.62 
                 89.08 
                 81.845 
                 108.840 
               
               
                   
               
             
          
         
       
     
         [0079]    The results (in Table 4) show that the control effect of the combination of benziothiazolinone with boscalid on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0080]    (5) Toxicity Test of Benziothiazolinone Combined with Fenamidone on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with fenamidone 
               
               
                 on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 10.59 
                 100 
                 / 
                 / 
               
               
                 Fenamidone 
                 12.78 
                 82.86 
                 / 
                 / 
               
               
                 Benziothiazolinone:fenamidone = 
                 10.13 
                 104.54 
                 99.664 
                 104.892 
               
               
                 50:1 
               
               
                 Benziothiazolinone:fenamidone = 
                 8.64 
                 122.57 
                 99.447 
                 123.252 
               
               
                 30:1 
               
               
                 Benziothiazolinone:fenamidone = 
                 6.68 
                 158.53 
                 98.442 
                 161.039 
               
               
                 10:1 
               
               
                 Benziothiazolinone:fenamidone = 
                 7.27 
                 145.67 
                 91.432 
                 159.321 
               
               
                 1:1 
               
               
                 Benziothiazolinone:fenamidone = 
                 7.92 
                 133.71 
                 84.422 
                 158.383 
               
               
                 1:10 
               
               
                 Benziothiazolinone:fenamidone = 
                 10.43 
                 101.53 
                 83.417 
                 121.714 
               
               
                 1:30 
               
               
                 Benziothiazolinone:fenamidone = 
                 12.27 
                 86.31 
                 83.2 
                 103.738 
               
               
                 1:50 
               
               
                   
               
             
          
         
       
     
         [0081]    The results (in Table 5) show that the control effect of the combination of benziothiazolinone with fenamidone on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0082]    (6) Toxicity Test of Benziothiazolinone Combined with Fluopicolide on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 6 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with fluopicolide 
               
               
                 on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 12.17 
                 100 
                 / 
                 / 
               
               
                 Fluopicolide 
                 15.32 
                 79.44 
                 / 
                 / 
               
               
                 Benziothiazolinone:fluopicolide = 50:1 
                 11.62 
                 104.73 
                 99.597 
                 105.154 
               
               
                 Benziothiazolinone:fluopicolide = 30:1 
                 10.13 
                 120.14 
                 99.337 
                 120.942 
               
               
                 Benziothiazolinone:fluopicolide = 10:1 
                 8.74 
                 139.24 
                 98.131 
                 141.892 
               
               
                 Benziothiazolinone:fluopicolide = 1:1 
                 8.12 
                 149.88 
                 89.719 
                 167.055 
               
               
                 Benziothiazolinone:fluopicolide = 1:10 
                 8.49 
                 143.35 
                 81.308 
                 176.305 
               
               
                 Benziothiazolinone:fluopicolide = 1:30 
                 12.18 
                 99.92 
                 80.102 
                 124.741 
               
               
                 Benziothiazolinone:fluopicolide = 1:50 
                 13.44 
                 90.55 
                 79.842 
                 113.411 
               
               
                   
               
             
          
         
       
     
         [0083]    The results (in Table 6) show that the control effect of the combination of benziothiazolinone with fluopicolide on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0084]    (7) Toxicity Test of Benziothiazolinone Combined with Famoxadone on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with famoxadone 
               
               
                 on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 11.36 
                 100 
                 / 
                 / 
               
               
                 Famoxadone 
                 13.81 
                 82.26 
                 / 
                 / 
               
               
                 Benziothiazolinone:famoxadone = 50:1 
                 10.56 
                 107.58 
                 99.652 
                 107.956 
               
               
                 Benziothiazolinone:famoxadone = 30:1 
                 9.47 
                 119.96 
                 99.428 
                 120.650 
               
               
                 Benziothiazolinone:famoxadone = 10:1 
                 8.69 
                 130.72 
                 98.387 
                 132.863 
               
               
                 Benziothiazolinone:famoxadone = 1:1 
                 8.21 
                 138.37 
                 91.13 
                 151.838 
               
               
                 Benziothiazolinone:famoxadone = 1:10 
                 9.42 
                 120.59 
                 83.872 
                 143.779 
               
               
                 Benziothiazolinone:famoxadone = 1:30 
                 11.08 
                 102.53 
                 82.832 
                 123.781 
               
               
                 Benziothiazolinone:famoxadone = 1:50 
                 12.15 
                 93.5 
                 82.607 
                 113.187 
               
               
                   
               
             
          
         
       
     
         [0085]    The results (in Table 7) show that the control effect of the combination of benziothiazolinone with famoxadone on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0086]    (8) Toxicity Test of Benziothiazolinone Combined with Pyraclostrobin on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 pyraclostrobin on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 11.85 
                 100 
                 / 
                 / 
               
               
                 pyraclostrobin 
                 10.69 
                 110.85 
                 / 
                 / 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 10.19 
                 116.29 
                 100.213 
                 116.043 
               
               
                 50:1 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 9.52 
                 124.47 
                 100.35 
                 124.036 
               
               
                 30:1 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 7.41 
                 159.92 
                 100.986 
                 158.359 
               
               
                 10:1 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 7.12 
                 166.43 
                 105.426 
                 157.864 
               
               
                 1:1 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 8.27 
                 143.29 
                 109.865 
                 130.424 
               
               
                 1:10 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 8.71 
                 136.05 
                 110.501 
                 123.121 
               
               
                 1:30 
               
               
                 Benziothiazolinone:pyraclostrobin = 
                 10.15 
                 116.75 
                 110.638 
                 105.524 
               
               
                 1:50 
               
               
                   
               
             
          
         
       
     
         [0087]    The results (in Table 8) show that the control effect of the combination of benziothiazolinone with pyraclostrobin on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0088]    (9) Toxicity Test of Benziothiazolinone Combined with Picoxystrobin on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 picoxystrobin on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 14.18 
                 100 
                 / 
                 / 
               
               
                 Picoxystrobin 
                 15.31 
                 92.62 
                 / 
                 / 
               
               
                 Benziothiazolinone:picoxystrobin = 50:1 
                 13.08 
                 108.41 
                 99.855 
                 108.567 
               
               
                 Benziothiazolinone:picoxystrobin = 30:1 
                 11.46 
                 123.73 
                 99.762 
                 124.025 
               
               
                 Benziothiazolinone:picoxystrobin = 10:1 
                 9.87 
                 143.67 
                 99.329 
                 144.641 
               
               
                 Benziothiazolinone:picoxystrobin = 1:1 
                 9.93 
                 142.8 
                 96.31 
                 148.271 
               
               
                 Benziothiazolinone:picoxystrobin = 1:10 
                 10.16 
                 139.57 
                 93.29 
                 149.609 
               
               
                 Benziothiazolinone:picoxystrobin = 1:30 
                 12.42 
                 114.17 
                 92.857 
                 122.952 
               
               
                 Benziothiazolinone:picoxystrobin = 1:50 
                 14.45 
                 98.13 
                 92.764 
                 105.785 
               
               
                   
               
             
          
         
       
     
         [0089]    The results (in Table 9) show that the control effect of the combination of benziothiazolinone with picoxystrobin on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0090]    (10) Toxicity Test of Benziothiazolinone Combined with Fluazinam on Downy Mildew Pathogens of Grape 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 10 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with fluazinam on downy mildew pathogens of grape 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone hydrochloride 
                 12.87 
                 100 
                 / 
                 / 
               
               
                 Fluazinam 
                 11.24 
                 114.5 
                 / 
                 / 
               
               
                 Benziothiazolinone:fluazinam = 50:1 
                 11.16 
                 115.32 
                 100.284 
                 114.993 
               
               
                 Benziothiazolinone:fluazinam = 30:1 
                 10.22 
                 125.93 
                 100.468 
                 125.343 
               
               
                 Benziothiazolinone:fluazinam = 10:1 
                 8.27 
                 155.62 
                 101.318 
                 153.596 
               
               
                 Benziothiazolinone:fluazinam = 1:1 
                 7.81 
                 164.79 
                 107.251 
                 153.649 
               
               
                 Benziothiazolinone:fluazinam = 1:10 
                 8.12 
                 158.5 
                 113.183 
                 140.039 
               
               
                 Benziothiazolinone:fluazinam = 1:30 
                 9.18 
                 140.2 
                 114.034 
                 122.946 
               
               
                 Benziothiazolinone:fluazinam = 1:50 
                 10.45 
                 123.16 
                 114.217 
                 107.830 
               
               
                   
               
             
          
         
       
     
         [0091]    The results (in Table 10) show that the control effect of the combination of benziothiazolinone with fluazinam on downy mildew of grape is significantly improved, suggesting that the combination has an obvious synergistic effect on downy mildew pathogens of grape. 
         [0092]    2. Toxicity Test of Benziothiazolinone Combined Respectively with Pyraclostrobin, Boscalid, Benthiavalicarb-Isopropyl, Zoxamide, and Fenamidone on Late Blight Pathogens of Potato 
         [0093]    The test method was the same as above. (The test results are shown in Tables 11, 12, 13, 14, and 15 respectively) 
         [0094]    (1) Toxicity Test of Benziothiazolinone Combined with Pyraclostrobin on Late Blight Pathogens of Potato 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 11 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with pyraclostrobin on late blight pathogens of potato 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
               
                 Benziothiazolinone 
                 6.89 
                 100.00 
                 / 
                 / 
               
               
                 pyraclostrobin 
                 5.28 
                 130.49 
                 / 
                 / 
               
               
                 Benziothiazolinone:pyraclostrobin = 50:1 
                 5.72 
                 120.45 
                 100.598 
                 119.74 
               
               
                 Benziothiazolinone:pyraclostrobin = 30:1 
                 5.44 
                 126.65 
                 100.984 
                 125.42 
               
               
                 Benziothiazolinone:pyraclostrobin = 10:1 
                 4.63 
                 148.81 
                 102.772 
                 144.80 
               
               
                 Benziothiazolinone:pyraclostrobin = 1:1 
                 3.32 
                 207.53 
                 115.246 
                 180.08 
               
               
                 Benziothiazolinone:pyraclostrobin = 1:10 
                 2.93 
                 235.15 
                 127.720 
                 184.12 
               
               
                 Benziothiazolinone:pyraclostrobin = 1:30 
                 4.21 
                 163.66 
                 129.509 
                 126.37 
               
               
                 Benziothiazolinone:pyraclostrobin = 1:50 
                 4.68 
                 147.22 
                 129.895 
                 113.34 
               
               
                   
               
             
          
         
       
     
         [0095]    The results (in Table 11) show that the control effect of the combination of benziothiazolinone with pyraclostrobin on late blight of potato is significantly improved, suggesting that the combination has an obvious synergistic effect on late blight pathogens of potato. 
         [0096]    (2) Toxicity Test of Benziothiazolinone Combined with Boscalid on Late Blight Pathogens of Potato 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 12 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with boscalid on late blight pathogens of potato 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 5.58 
                 100.00 
                 / 
                 / 
               
               
                 Boscalid 
                 6.31 
                 88.43 
                 / 
                 / 
               
               
                 Benziothiazolinone:boscalid = 50:1 
                 4.78 
                 116.74 
                 99.7732 
                 117.005 
               
               
                 Benziothiazolinone:boscalid = 30:1 
                 4.62 
                 120.78 
                 99.6268 
                 121.232 
               
               
                 Benziothiazolinone:boscalid = 10:1 
                 4.21 
                 132.54 
                 98.9483 
                 133.950 
               
               
                 Benziothiazolinone:boscalid = 1:1 
                 3.28 
                 170.12 
                 94.2155 
                 180.567 
               
               
                 Benziothiazolinone:boscalid = 1:10 
                 3.18 
                 175.47 
                 89.4828 
                 196.095 
               
               
                 Benziothiazolinone:boscalid = 1:30 
                 4.91 
                 113.65 
                 88.8043 
                 127.973 
               
               
                 Benziothiazolinone:boscalid = 1:50 
                 5.55 
                 100.54 
                 88.6579 
                 113.403 
               
               
                   
               
             
          
         
       
     
         [0097]    The results (in Table 12) show that the control effect of the combination of benziothiazolinone with boscalid on late blight of potato is significantly improved, suggesting that the combination has an obvious synergistic effect on late blight pathogens of potato. 
         [0098]    (3) Toxicity Test of Benziothiazolinone Combined with Benthiavalicarb-Isopropyl on Late Blight Pathogens of Potato 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 13 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 benthiavalicarb-isopropyl on late blight pathogens of potato 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 EC 50  (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 6.22 
                 100.000 
                 / 
                 / 
               
               
                 Benthiavalicarb-isopropyl 
                 6.73 
                 92.422 
                 / 
                 / 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.43 
                 114.549 
                 99.851 
                 114.719 
               
               
                 isopropyl = 50:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.11 
                 121.722 
                 99.756 
                 122.020 
               
               
                 isopropyl = 30:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 4.17 
                 149.161 
                 99.311 
                 150.195 
               
               
                 isopropyl = 10:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 3.69 
                 168.564 
                 96.211 
                 175.202 
               
               
                 isopropyl = 1:1 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 4.25 
                 146.353 
                 93.111 
                 157.181 
               
               
                 isopropyl = 1:10 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.23 
                 118.929 
                 92.666 
                 128.341 
               
               
                 isopropyl = 1:30 
               
               
                 Benziothiazolinone:benthiavalicarb- 
                 5.61 
                 110.873 
                 92.571 
                 119.772 
               
               
                 isopropyl = 1:50 
               
               
                   
               
             
          
         
       
     
         [0099]    The results (in Table 13) show that the control effect of the combination of benziothiazolinone with benthiavalicarb-isopropyl on late blight of potato is significantly improved, suggesting that the combination has an obvious synergistic effect on late blight pathogens of potato. 
         [0100]    (4) Toxicity Test of Benziothiazolinone Combined with Zoxamide on Late Blight Pathogens of Potato 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 14 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with zoxamide on late blight pathogens of potato 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 5.89 
                 100.00 
                 / 
                 / 
               
               
                 Zoxamide 
                 6.21 
                 94.85 
                 / 
                 / 
               
               
                 Benziothiazolinone:zoxamide = 50:1 
                 5.21 
                 113.05 
                 99.899 
                 113.164 
               
               
                 Benziothiazolinone:zoxamide = 30:1 
                 4.82 
                 122.2 
                 99.834 
                 122.403 
               
               
                 Benziothiazolinone:zoxamide = 10:1 
                 4.09 
                 144.01 
                 99.532 
                 144.687 
               
               
                 Benziothiazolinone:zoxamide = 1:1 
                 3.58 
                 164.53 
                 97.424 
                 168.880 
               
               
                 Benziothiazolinone:zoxamide = 1:10 
                 4.05 
                 145.43 
                 95.315 
                 152.578 
               
               
                 Benziothiazolinone:zoxamide = 1:30 
                 5.21 
                 113.05 
                 95.013 
                 118.984 
               
               
                 Benziothiazolinone:zoxamide = 1:50 
                 5.42 
                 108.67 
                 94.948 
                 114.452 
               
               
                   
               
             
          
         
       
     
         [0101]    The results (in Table 14) show that the control effect of the combination of benziothiazolinone with zoxamide on late blight of potato is significantly improved, suggesting that the combination has an obvious synergistic effect on late blight pathogens of potato. 
         [0102]    (5) Toxicity Test of Benziothiazolinone Combined with Fenamidone on Late Blight Pathogens of Potato 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 15 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with fenamidone on late blight pathogens of potato 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 6.12 
                 100.00 
                 / 
                 / 
               
               
                 Fenamidone 
                 6.58 
                 93.01 
                 / 
                 / 
               
               
                 Benziothiazolinone:fenamidone = 50:1 
                 5.31 
                 115.25 
                 99.863 
                 115.408 
               
               
                 Benziothiazolinone:fenamidone = 30:1 
                 4.52 
                 135.4 
                 99.774 
                 135.707 
               
               
                 Benziothiazolinone:fenamidone = 10:1 
                 4.15 
                 147.47 
                 99.364 
                 148.414 
               
               
                 Benziothiazolinone:fenamidone = 1:1 
                 3.61 
                 169.53 
                 96.505 
                 175.670 
               
               
                 Benziothiazolinone:fenamidone = 1:10 
                 4.23 
                 144.68 
                 93.645 
                 154.498 
               
               
                 Benziothiazolinone:fenamidone = 1:30 
                 5.16 
                 118.6 
                 93.235 
                 127.205 
               
               
                 Benziothiazolinone:fenamidone = 1:50 
                 5.37 
                 113.97 
                 93.146 
                 122.356 
               
               
                   
               
             
          
         
       
     
         [0103]    The results (in Table 15) show that the control effect of the combination of benziothiazolinone with fenamidone on late blight of potato is significantly improved, suggesting that the combination has an obvious synergistic effect on late blight pathogens of potato. 
         [0104]    3. Toxicity Test of Benziothiazolinone Combined Respectively with Fluazinam, Prothioconazole, Picoxystrobin, Fluopicolide, and Famoxadone on Rust Pathogens of Wheat 
         [0105]    Test target organism: rust pathogens of wheat 
         [0106]    The test method was the same as above. (The test results are shown in Tables 16, 17, 18, 19, and 20 respectively) 
         [0107]    (1) Toxicity Test of Benziothiazolinone Combined with Fluazinam on Rust Pathogens of Wheat 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 16 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with fluazinam on rust pathogens of wheat 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone hydrochloride 
                 7.68 
                 100 
                 / 
                 / 
               
               
                 Fluazinam 
                 8.15 
                 94.23 
                 / 
                 / 
               
               
                 Benziothiazolinone:fluazinam = 50:1 
                 6.82 
                 112.61 
                 99.887 
                 112.737 
               
               
                 Benziothiazolinone:fluazinam = 30:1 
                 6.41 
                 119.81 
                 99.814 
                 120.033 
               
               
                 Benziothiazolinone:fluazinam = 10:1 
                 5.68 
                 135.21 
                 99.476 
                 135.922 
               
               
                 Benziothiazolinone:fluazinam = 1:1 
                 5.21 
                 147.41 
                 97.117 
                 151.786 
               
               
                 Benziothiazolinone:fluazinam = 1:10 
                 5.56 
                 138.13 
                 94.757 
                 145.773 
               
               
                 Benziothiazolinone:fluazinam = 1:30 
                 6.46 
                 118.89 
                 94.419 
                 125.917 
               
               
                 Benziothiazolinone:fluazinam = 1:50 
                 6.87 
                 111.79 
                 94.346 
                 118.489 
               
               
                   
               
             
          
         
       
     
         [0108]    The results (in Table 16) show that the control effect of the combination of benziothiazolinone with fluazinam on rust of wheat is significantly improved, suggesting that the combination has an obvious synergistic effect on rust pathogens of wheat. 
         [0109]    (2) Toxicity Test of Benziothiazolinone Combined with Prothioconazole on Rust Pathogens of Wheat 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 17 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with prothioconazole on rust pathogens of wheat 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 7.92 
                 100 
                 / 
                 / 
               
               
                 Prothioconazole 
                 7.68 
                 103.13 
                 / 
                 / 
               
               
                 Benziothiazolinone:prothioconazole = 50:1 
                 7.11 
                 111.39 
                 100.061 
                 111.322 
               
               
                 Benziothiazolinone:prothioconazole = 30:1 
                 6.45 
                 122.79 
                 100.101 
                 122.666 
               
               
                 Benziothiazolinone:prothioconazole = 10:1 
                 5.61 
                 141.18 
                 100.284 
                 140.780 
               
               
                 Benziothiazolinone:prothioconazole = 1:1 
                 4.63 
                 171.06 
                 101.563 
                 168.427 
               
               
                 Benziothiazolinone:prothioconazole = 1:10 
                 5.27 
                 150.28 
                 102.841 
                 146.128 
               
               
                 Benziothiazolinone:prothioconazole = 1:30 
                 6.21 
                 127.54 
                 103.024 
                 123.796 
               
               
                 Benziothiazolinone:prothioconazole = 1:50 
                 6.62 
                 119.64 
                 103.064 
                 116.083 
               
               
                   
               
             
          
         
       
     
         [0110]    The results (in Table 17) show that the control effect of the combination of benziothiazolinone with prothioconazole on rust of wheat is significantly improved, suggesting that the combination has an obvious synergistic effect on rust pathogens of wheat. 
         [0111]    (3) Toxicity Test of Benziothiazolinone Combined with Picoxystrobin on Rust Pathogens of Wheat 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 18 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with picoxystrobin on rust pathogens of wheat 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 benziothiazolinone 
                 7.51 
                 100 
                 / 
                 / 
               
               
                 picoxystrobin 
                 8.26 
                 90.92 
                 / 
                 / 
               
               
                 benziothiazolinone:picoxystrobin = 50:1 
                 6.52 
                 115.18 
                 99.822 
                 115.385 
               
               
                 benziothiazolinone:picoxystrobin = 30:1 
                 6.21 
                 120.93 
                 99.707 
                 121.285 
               
               
                 benziothiazolinone:picoxystrobin = 10:1 
                 5.48 
                 137.04 
                 99.175 
                 138.180 
               
               
                 benziothiazolinone:picoxystrobin = 1:1 
                 4.31 
                 174.25 
                 95.46 
                 182.537 
               
               
                 benziothiazolinone:picoxystrobin = 1:10 
                 5.18 
                 144.98 
                 91.746 
                 158.023 
               
               
                 benziothiazolinone:picoxystrobin = 1:30 
                 6.72 
                 111.76 
                 91.213 
                 122.526 
               
               
                 benziothiazolinone:picoxystrobin = 1:50 
                 6.98 
                 107.59 
                 91.098 
                 118.104 
               
               
                   
               
             
          
         
       
     
         [0112]    The results (in Table 18) show that the control effect of the combination of benziothiazolinone with picoxystrobin on rust of wheat is significantly improved, suggesting that the combination has an obvious synergistic effect on rust pathogens of wheat. 
         [0113]    (4) Toxicity Test of Benziothiazolinone Combined with Fluopicolide on Rust Pathogens of Wheat 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 19 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined 
               
               
                 with fluopicolide on rust pathogens of wheat 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 7.93 
                 100 
                 / 
                 / 
               
               
                 Fluopicolide 
                 7.69 
                 103.12 
                 / 
                 / 
               
               
                 Benziothiazolinone:fluopicolide = 50:1 
                 6.98 
                 113.61 
                 100.061 
                 113.541 
               
               
                 Benziothiazolinone:fluopicolide = 30:1 
                 6.32 
                 125.47 
                 100.101 
                 125.343 
               
               
                 Benziothiazolinone:fluopicolide = 10:1 
                 5.26 
                 150.76 
                 100.284 
                 150.333 
               
               
                 Benziothiazolinone:fluopicolide = 1:1 
                 4.91 
                 161.51 
                 101.56 
                 159.029 
               
               
                 Benziothiazolinone:fluopicolide = 1:10 
                 5.32 
                 149.06 
                 102.837 
                 144.948 
               
               
                 Benziothiazolinone:fluopicolide = 1:30 
                 6.66 
                 119.07 
                 103.02 
                 115.579 
               
               
                 Benziothiazolinone:fluopicolide = 1:50 
                 6.85 
                 115.77 
                 103.06 
                 112.333 
               
               
                   
               
             
          
         
       
     
         [0114]    The results (in Table 19) show that the control effect of the combination of benziothiazolinone with fluopicolide on rust of wheat is significantly improved, suggesting that the combination has an obvious synergistic effect on rust pathogens of wheat. 
         [0115]    (5) Toxicity Test of Benziothiazolinone Combined with Famoxadone on Rust Pathogens of Wheat 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 20 
               
             
             
               
                   
               
               
                 Toxicity test result analysis of benziothiazolinone combined with 
               
               
                 famoxadone on rust pathogens of wheat 
               
             
          
           
               
                   
                   
                   
                   
                 Co-toxicity 
               
               
                   
                 EC 50   
                   
                   
                 coefficient 
               
               
                 Name of agent 
                 (μg/ml) 
                 ATI 
                 TTI 
                 (CTC) 
               
               
                   
               
             
          
           
               
                 Benziothiazolinone 
                 7.51 
                 100 
                 / 
                 / 
               
               
                 Famoxadone 
                 7.96 
                 94.35 
                 / 
                 / 
               
               
                 Benziothiazolinone:famoxadone = 50:1 
                 6.51 
                 115.36 
                 99.889 
                 115.488 
               
               
                 Benziothiazolinone:famoxadone = 30:1 
                 6.17 
                 121.72 
                 99.818 
                 121.942 
               
               
                 Benziothiazolinone:famoxadone = 10:1 
                 5.12 
                 146.68 
                 99.486 
                 147.438 
               
               
                 Benziothiazolinone:famoxadone = 1:1 
                 4.56 
                 164.69 
                 97.173 
                 169.481 
               
               
                 Benziothiazolinone:famoxadone = 1:10 
                 5.27 
                 142.5 
                 94.861 
                 150.220 
               
               
                 Benziothiazolinone:famoxadone = 1:30 
                 6.52 
                 115.18 
                 94.529 
                 121.846 
               
               
                 Benziothiazolinone:famoxadone = 1:50 
                 7.21 
                 104.16 
                 94.458 
                 110.271 
               
               
                   
               
             
          
         
       
     
         [0116]    The results (in Table 20) show that the control effect of the combination of benziothiazolinone with famoxadone on rust of wheat is significantly improved, suggesting that the combination has an obvious synergistic effect on rust pathogens of wheat. 
       (II) Field Efficacy Test 
       [0117]    Test method: in early stage of disease development, the first spray was given immediately, and then the second application was given after 7 days. Each treatment included 4 plots of 20 square meters each. The disease development before application and 10 days after the second application was statistically investigated. Samples were collected from 5 locations in each plot at random, and 5 plants were investigated at each location by investigating the percentages of the disease spot area on the leaves relative to the leaf area of the whole plant and grading. The disease index and the control effect were calculated. 
         [0000]              Disease                 index     =         ∑     (                   Number                 of                 leaves                 at                 each               grade                 of                 disease                 development           ×                     Representative                 value               of                 corresponding                 grade                 )         (             Total                 number                 of               leaves                 investigated           ×         Representative             value                 of                 highest                 level             )       ×   100                   Control                 effect                   (   %   )       =       (     1   -               Disease                 index                 of                 control               group                 before                 application           ×           Disease                 index                 of                 treatment               group                 after                 application                       Disease                 index                 of                 control               group                 after                 application           ×           Disease                 index                 of                 treatment               group                 before                 application                 )     ×   100           Anticipated control effect (%)= X+Y−XY/ 100 (where  X  and  Y  are the control effect of a single agent) 
         [0118]    Grade Scale: 
         [0119]    Grade 0: no disease spot; 
         [0120]    Grade 1: number of disease spots on the leaf &lt;5, and length &lt;1 cm; 
         [0121]    Grade 3: 6≦number of disease spots on the leaf ≦10, and length of some disease spots &gt;1 cm; 
         [0122]    Grade 5: 11≦number of disease spots on the leaf ≦25, some disease spots are contiguous, and the disease spot area is 10-25% of the leaf area; 
         [0123]    Grade 7: number of disease spots on the leaf ≧26, the disease spots are contiguous, and the disease spot area is 26-50% of the leaf area; 
         [0124]    Grade 9: the disease spots are contiguous, and the disease spot area is above 50% of the leaf area, or all the leaves all wilted. 
         [0125]    1. Field Efficacy Test of Benziothiazolinone Combined Respectively with Pyraclostrobin, Prothioconazole, Picoxystrobin, Fluopicolide, and Famoxadone for Controlling Wheat Powdery Mildew 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 21 
               
             
             
               
                   
               
               
                 Field efficacy test of benziothiazolinone combined 
               
               
                 with the above fungicides for wheat powdery mildew 
               
             
          
           
               
                   
                   
                 Day 11 after the 
               
               
                   
                   
                 second 
               
               
                   
                 Disease 
                 application 
               
             
          
           
               
                   
                   
                 Application 
                 index 
                   
                 Control 
               
               
                   
                   
                 rate 
                 before 
                 Disease 
                 effect 
               
               
                 No. 
                 Treatment agent 
                 (a.i.g/ha) 
                 application 
                 index 
                 (%) 
               
               
                   
               
             
          
           
               
                 Example 
                 5% benziothiazolinone 
                 145.2 
                 4.02 
                 7.51 
                 75.2 
               
               
                 22 
                 microemulsion 
               
               
                   
                 10% pyraclostrobin aqueous 
                 4.8 
                 4.14 
                 29.24 
                 6.2 
               
               
                   
                 solution 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.7 
               
               
                   
                 mixing them 
               
               
                   
                 62% 
                 150 
                 4.43 
                 5.40 
                 83.8 
               
               
                   
                 benziothiazolinone•pyraclostrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:pyraclostrobin = 
               
               
                   
                 60:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 75 
                 4.72 
                 20.19 
                 43.2 
               
               
                 23 
                 microemulsion 
               
               
                   
                 10% pyraclostrobin aqueous 
                 75 
                 4.83 
                 19.60 
                 46.1 
               
               
                   
                 solution 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 69.4 
               
               
                   
                 mixing them 
               
               
                   
                 50% 
                 150 
                 4.19 
                 5.43 
                 82.8 
               
               
                   
                 benziothiazolinone•pyraclostrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:pyraclostrobin = 
               
               
                   
                 25:25) 
               
               
                 Example 
                 5% benziothiazolinone 
                 4.8 
                 4.6 
                 33.22 
                 4.1 
               
               
                 24 
                 microemulsion 
               
               
                   
                 10% pyraclostrobin aqueous 
                 145.2 
                 4.63 
                 8.05 
                 76.9 
               
               
                   
                 solution 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 77.8 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 150 
                 4.62 
                 5.18 
                 85.1 
               
               
                   
                 benziothiazolinone•pyraclostrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:pyraclostrobin = 
               
               
                   
                 2:63) 
               
               
                 Example 7 
                 5% benziothiazolinone 
                 145.2 
                 4.46 
                 9.10 
                 72.9 
               
               
                   
                 microemulsion 
               
               
                   
                 25% prothioconazole wettable 
                 4.8 
                 4.79 
                 34.20 
                 5.2 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 74.3 
               
               
                   
                 mixing them 
               
               
                   
                 62% 
                 150 
                 4.74 
                 5.07 
                 85.8 
               
               
                   
                 benziothiazolinone•prothioconazole 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:prothioconazole = 
               
               
                   
                 60:2) 
               
               
                 Example 8 
                 5% benziothiazolinone 
                 75 
                 4.47 
                 19.02 
                 43.5 
               
               
                   
                 microemulsion 
               
               
                   
                 25% prothioconazole wettable 
                 75 
                 4.25 
                 17.22 
                 46.2 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 69.6 
               
               
                   
                 mixing them 
               
               
                   
                 40% 
                 150 
                 4.36 
                 5.29 
                 83.9 
               
               
                   
                 benziothiazolinone•prothioconazole 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:prothioconazole = 
               
               
                   
                 20:20) 
               
               
                 Example 9 
                 5% benziothiazolinone 
                 4.6 
                 4.63 
                 33.51 
                 3.9 
               
               
                   
                 microemulsion 
               
               
                   
                 25% prothioconazole wettable 
                 145.4 
                 4.04 
                 6.75 
                 77.8 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 78.7 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 150 
                 4.33 
                 4.83 
                 85.2 
               
               
                   
                 benziothiazolinone•prothioconazole 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:prothioconazole = 
               
               
                   
                 2:63) 
               
               
                 Example 
                 5% benziothiazolinone 
                 145.4 
                 4.17 
                 7.66 
                 75.6 
               
               
                 25 
                 microemulsion 
               
               
                   
                 15% picoxystrobin concentrate 
                 4.6 
                 4.02 
                 28.79 
                 4.9 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.8 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 150 
                 4.23 
                 4.84 
                 84.8 
               
               
                   
                 benziothiazolinone•picoxystrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:picoxystrobin = 
               
               
                   
                 63:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 75 
                 4.47 
                 18.98 
                 43.6 
               
               
                 26 
                 microemulsion 
               
               
                   
                 15% picoxystrobin concentrate 
                 75 
                 4.16 
                 17.17 
                 45.2 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 69.1 
               
               
                   
                 mixing them 
               
               
                   
                 30% 
                 150 
                 4.32 
                 4.52 
                 86.1 
               
               
                   
                 benziothiazolinone•picoxystrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:picoxystrobin = 
               
               
                   
                 15:15) 
               
               
                 Example 
                 5% benziothiazolinone 
                 4 
                 4.42 
                 31.99 
                 3.9 
               
               
                 27 
                 microemulsion 
               
               
                   
                 15% picoxystrobin concentrate 
                 146 
                 4.03 
                 6.92 
                 77.2 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 78.1 
               
               
                   
                 mixing them 
               
               
                   
                 75% 
                 150 
                 4.02 
                 4.21 
                 86.1 
               
               
                   
                 benziothiazolinone•picoxystrobin 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:picoxystrobin = 
               
               
                   
                 2:73) 
               
               
                 Example 
                 5% benziothiazolinone 
                 146 
                 4.13 
                 7.43 
                 76.1 
               
               
                 16 
                 microemulsion 
               
               
                   
                 10% fluopicolide suspension 
                 4 
                 3.87 
                 27.63 
                 5.2 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 77.3 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 150 
                 3.81 
                 4.33 
                 84.9 
               
               
                   
                 benziothiazolinone•fluopicolide 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:picoxystrobin = 
               
               
                   
                 63:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 75 
                 3.77 
                 16.07 
                 43.4 
               
               
                 17 
                 microemulsion 
               
               
                   
                 10% fluopicolide suspension 
                 75 
                 3.82 
                 15.48 
                 46.2 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 69.5 
               
               
                   
                 mixing them 
               
               
                   
                 50% 
                 150 
                 4.1 
                 3.98 
                 87.1 
               
               
                   
                 benziothiazolinone•fluopicolide 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluopicolide = 
               
               
                   
                 25:25) 
               
               
                 Example 
                 5% benziothiazolinone 
                 4 
                 4.23 
                 30.58 
                 4.0 
               
               
                 18 
                 microemulsion 
               
               
                   
                 10% fluopicolide suspension 
                 146 
                 4.02 
                 7.54 
                 75.1 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.1 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 150 
                 4.43 
                 5.07 
                 84.8 
               
               
                   
                 benziothiazolinone•fluopicolide 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone•fluopicolide = 
               
               
                   
                 2:63) 
               
               
                 Example 
                 5% benziothiazolinone 
                 145 
                 4.23 
                 7.74 
                 75.7 
               
               
                 19 
                 microemulsion 
               
               
                   
                 30% famoxadone wettable 
                 5 
                 4.8 
                 33.91 
                 6.2 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 77.2 
               
               
                   
                 mixing them 
               
               
                   
                 60% 
                 150 
                 4.42 
                 4.63 
                 86.1 
               
               
                   
                 benziothiazolinone•famoxadone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:famoxadone = 
               
               
                   
                 58:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 75 
                 3.76 
                 16.11 
                 43.1 
               
               
                 20 
                 microemulsion 
               
               
                   
                 30% famoxadone wettable 
                 75 
                 3.89 
                 15.76 
                 46.2 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 69.4 
               
               
                   
                 mixing them 
               
               
                   
                 50% 
                 150 
                 4.06 
                 4.34 
                 85.8 
               
               
                   
                 benziothiazolinone•famoxadone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:famoxadone = 
               
               
                   
                 25:25) 
               
               
                 Example 
                 5% benziothiazolinone 
                 5 
                 4.12 
                 29.57 
                 4.7 
               
               
                 21 
                 microemulsion 
               
               
                   
                 30% famoxadone wettable 
                 150 
                 4.33 
                 8.09 
                 75.2 
               
               
                   
                 powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.4 
               
               
                   
                 mixing them 
               
               
                   
                 60% 
                 150 
                 4.3 
                 4.50 
                 86.1 
               
               
                   
                 benziothiazolinone•famoxadone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:famoxadone = 
               
               
                   
                 2:58) 
               
               
                 Water 
                 — 
                 — 
                 3.28 
                 24.7 
                 — 
               
               
                 control 
               
               
                 (CK) 
               
               
                   
               
             
          
         
       
     
         [0126]    The test results (in Table 21) show that the control effect of the combination of benziothiazolinone with pyraclostrobin, prothioconazole, picoxystrobin, fluopicolide, and famoxadone respectively on wheat powdery mildew is significantly improved, suggesting that the combination has an obvious synergistic effect on wheat powdery mildew. 
         [0127]    (2) Field Efficacy Test of Benziothiazolinone Combined Respectively with Fluazinam, Boscalid, and Fluopicolide for Controlling Tomato Grey Mold 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 22 
               
             
             
               
                   
               
               
                 Field efficacy test of benziothiazolinone or a salt thereof combined 
               
               
                 respectively with the above fungicides for tomato grey mold 
               
             
          
           
               
                   
                   
                 Day 11 after the 
               
               
                   
                   
                 second 
               
               
                   
                 Disease 
                 application 
               
             
          
           
               
                   
                   
                 Application 
                 index 
                   
                 Control 
               
               
                   
                   
                 rate 
                 before 
                 Disease 
                 effect 
               
               
                 No. 
                 Treatment agent 
                 (a.i.g/ha) 
                 application 
                 index 
                 (%) 
               
               
                   
               
             
          
           
               
                 Example 
                 5% benziothiazolinone 
                 117 
                 5.9 
                 3.03 
                 82.15 
               
               
                 28 
                 microemulsion 
               
               
                   
                 12.5% fluazinam suspension 
                 3 
                 6.23 
                 17.42 
                 2.95 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 82.68 
               
               
                   
                 mixing them 
               
               
                   
                 62% benziothiazolinone•fluazinam 
                 120 
                 6.03 
                 2.44 
                 85.95 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluazinam = 
               
               
                   
                 60:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 60 
                 6.12 
                 8.05 
                 54.35 
               
               
                 29 
                 microemulsion 
               
               
                   
                 12.5% fluazinam suspension 
                 60 
                 6.23 
                 10.42 
                 41.95 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 73.50 
               
               
                   
                 mixing them 
               
               
                   
                 40% benziothiazolinone•fluazinam 
                 120 
                 6.25 
                 2.28 
                 87.35 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluazinam = 
               
               
                   
                 20:20) 
               
               
                 Example 
                 5% benziothiazolinone 
                 3.2 
                 5.83 
                 15.77 
                 6.15 
               
               
                 30 
                 microemulsion 
               
               
                   
                 12.5% fluazinam suspension 
                 116.8 
                 5.78 
                 4.12 
                 75.25 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.77 
               
               
                   
                 mixing them 
               
               
                   
                 75% benziothiazolinone 
                 120 
                 5.89 
                 2.49 
                 85.35 
               
               
                   
                 carbonate•fluazinam wettable 
               
               
                   
                 powder (benziothiazolinone:fluazinam = 
               
               
                   
                 2:73) 
               
               
                 Example 
                 5% benziothiazolinone 
                 116.3 
                 5.67 
                 2.85 
                 82.55 
               
               
                 10 
                 microemulsion 
               
               
                   
                 20% boscalid aqueous emulsion 
                 3.7 
                 5.83 
                 16.25 
                 3.25 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 83.12 
               
               
                   
                 mixing them 
               
               
                   
                 65% benziothiazolinone•boscalid 
                 120 
                 5.7 
                 2.24 
                 86.35 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:boscalid = 
               
               
                   
                 63:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 60 
                 5.89 
                 7.76 
                 54.25 
               
               
                 11 
                 microemulsion 
               
               
                   
                 20% boscalid aqueous emulsion 
                 60 
                 6.23 
                 9.43 
                 47.45 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 75.96 
               
               
                   
                 mixing them 
               
               
                   
                 60% benziothiazolinone•boscalid 
                 120 
                 5.9 
                 2.17 
                 87.25 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:boscalid = 
               
               
                   
                 30:30) 
               
               
                 Example 
                 5% benziothiazolinone 
                 3.9 
                 6.12 
                 16.73 
                 5.15 
               
               
                 12 
                 microemulsion 
               
               
                   
                 20% boscalid aqueous emulsion 
                 116.1 
                 5.78 
                 4.12 
                 75.25 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 76.52 
               
               
                   
                 mixing them 
               
               
                   
                 62% benziothiazolinone•boscalid 
                 120 
                 6.03 
                 2.46 
                 85.85 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:boscalid = 
               
               
                   
                 2:60) 
               
               
                 Example 
                 5% benziothiazolinone 
                 117.3 
                 6.33 
                 2.96 
                 83.75 
               
               
                 16 
                 microemulsion 
               
               
                   
                 30% fluopicolide aqueous emulsion 
                 2.8 
                 6.33 
                 17.83 
                 2.25 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 84.12 
               
               
                   
                 mixing them 
               
               
                   
                 65% benziothiazolinone•fluopicolide 
                 120 
                 6.23 
                 2.49 
                 86.15 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluopicolide = 
               
               
                   
                 63:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 60 
                 6.53 
                 8.42 
                 55.25 
               
               
                 17 
                 microemulsion 
               
               
                   
                 30% fluopicolide aqueous emulsion 
                 60 
                 6.14 
                 9.05 
                 48.85 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 77.11 
               
               
                   
                 mixing them 
               
               
                   
                 50% benziothiazolinone•fluopicolide 
                 120 
                 6.16 
                 2.60 
                 85.35 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluopicolide = 
               
               
                   
                 25:25) 
               
               
                 Example 
                 5% benziothiazolinone 
                 3.7 
                 5.88 
                 16.00 
                 5.55 
               
               
                 18 
                 microemulsion 
               
               
                   
                 30% fluopicolide aqueous emulsion 
                 116.3 
                 5.9 
                 2.95 
                 82.65 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 83.61 
               
               
                   
                 mixing them 
               
               
                   
                 65% benziothiazolinone•fluopicolide 
                 120 
                 6.06 
                 2.38 
                 86.35 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fluopicolide = 
               
               
                   
                 2:63) 
               
               
                 Water 
                 Water control 
                 — 
                 6.08 
                 17.52 
                 — 
               
               
                 control 
               
               
                 (CK) 
               
               
                   
               
             
          
         
       
     
         [0128]    The test results (in Table 22) show that the control effect of the combination of benziothiazolinone with fluazinam, boscalid, and fluopicolide respectively on tomato grey mold is significantly improved, suggesting that the combination has an obvious synergistic effect on tomato grey mold. 
         [0129]    (3) Field Efficacy Test of Benziothiazolinone Combined Respectively with Benthiavalicarb-Isopropyl, Zoxamide, and Fenamidone for Controlling Grape Anthracnose 
         [0000]    
       
         
               
             
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 23 
               
             
             
               
                   
               
               
                 Field efficacy test of benziothiazolinone combined respectively 
               
               
                 with the above fungicides for grape anthracnose 
               
             
          
           
               
                   
                 Day 11 after the 
               
               
                   
                 second application 
               
             
          
           
               
                   
                   
                 Application 
                 Disease index 
                   
                 Control 
               
               
                   
                   
                 rate 
                 before 
                 Disease 
                 effect 
               
               
                 No. 
                 Treatment agent 
                 (a.i.g/ha) 
                 application 
                 index 
                 (%) 
               
               
                   
               
             
          
           
               
                 Example 1 
                 5% benziothiazolinone 
                 130.2 
                 3.89 
                 4.65 
                 83.1 
               
               
                   
                 microemulsion 
               
               
                   
                 10% benthiavalicarb-isopropyl 
                 4.8 
                 3.98 
                 26.83 
                 4.6 
               
               
                   
                 wettable powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 83.9 
               
               
                   
                 mixing them 
               
               
                   
                 62% 
                 135 
                 3.87 
                 3.77 
                 86.2 
               
               
                   
                 benziothiazolinone•benthiavalicarb- 
               
               
                   
                 isopropyl wettable powder 
               
               
                   
                 (benziothiazolinone:benthiavalicarb- 
               
               
                   
                 isopropyl = 60:2) 
               
               
                 Example 2 
                 5% benziothiazolinone 
                 67.5 
                 3.76 
                 14.06 
                 47.1 
               
               
                   
                 microemulsion 
               
               
                   
                 10% benthiavalicarb-isopropyl 
                 67.5 
                 4.04 
                 16.22 
                 43.2 
               
               
                   
                 wettable powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 70.0 
               
               
                   
                 mixing them 
               
               
                   
                 50% 
                 135 
                 3.93 
                 3.58 
                 87.1 
               
               
                   
                 benziothiazolinone•benthiavalicarb- 
               
               
                   
                 isopropyl wettable powder 
               
               
                   
                 (benziothiazolinone:benthiavalicarb- 
               
               
                   
                 isopropyl = 25:25) 
               
               
                 Example 3 
                 5% benziothiazolinone 
                 3.6 
                 3.87 
                 25.38 
                 7.2 
               
               
                   
                 microemulsion 
               
               
                   
                 10% benthiavalicarb-isopropyl 
                 131.4 
                 3.87 
                 5.96 
                 78.2 
               
               
                   
                 wettable powder 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 79.8 
               
               
                   
                 mixing them 
               
               
                   
                 65% 
                 135 
                 3.94 
                 3.87 
                 86.1 
               
               
                   
                 benziothiazolinone•benthiayalicarb- 
               
               
                   
                 isopropyl wettable powder 
               
               
                   
                 (benziothiazolinone:benthiayalicarb- 
               
               
                   
                 isopropyl = 2:63) 
               
               
                 Example 4 
                 5% benziothiazolinone 
                 130.6 
                 3.65 
                 4.62 
                 82.1 
               
               
                   
                 microemulsion 
               
               
                   
                 15% zoxamide wettable powder 
                 4.4 
                 3.89 
                 26.20 
                 4.7 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 82.9 
               
               
                   
                 mixing them 
               
               
                   
                 85% benziothiazolinone•zoxamide 
                 135 
                 3.79 
                 3.72 
                 86.1 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:zoxamide = 
               
               
                   
                 83:2) 
               
               
                 Example 5 
                 5% benziothiazolinone 
                 67.5 
                 3.78 
                 14.00 
                 47.6 
               
               
                   
                 microemulsion 
               
               
                   
                 15% zoxamide wettable powder 
                 67.5 
                 3.85 
                 15.10 
                 44.5 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 70.9 
               
               
                   
                 mixing them 
               
               
                   
                 30% benziothiazolinone•zoxamide 
                 135 
                 3.91 
                 3.81 
                 86.2 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:zoxamide = 
               
               
                   
                 15:15) 
               
               
                 Example 6 
                 5% benziothiazolinone 
                 4.2 
                 3.86 
                 25.12 
                 7.9 
               
               
                   
                 microemulsion 
               
               
                   
                 15% zoxamide wettable powder 
                 130.8 
                 3.82 
                 5.37 
                 80.1 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 81.7 
               
               
                   
                 mixing them 
               
               
                   
                 75% benziothiazolinone•zoxamide 
                 135 
                 3.79 
                 3.96 
                 85.2 
               
               
                   
                 wettable powder 
               
               
                   
                 benziothiazolinone:zoxamide = 
               
               
                   
                 2:73) 
               
               
                 Example 
                 5% benziothiazolinone 
                 131.8 
                 3.91 
                 5.44 
                 80.3 
               
               
                 13 
                 microemulsion 
               
               
                   
                 20% fenamidone wettable powder 
                 3.2 
                 3.21 
                 21.57 
                 4.9 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 81.3 
               
               
                   
                 mixing them 
               
               
                   
                 62% 
                 135 
                 3.79 
                 3.80 
                 85.8 
               
               
                   
                 benziothiazolinone•fenamidone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fenamidone = 60:2) 
               
               
                 Example 
                 5% benziothiazolinone 
                 67.5 
                 3.98 
                 14.60 
                 48.1 
               
               
                 14 
                 microemulsion 
               
               
                   
                 20% fenamidone wettable powder 
                 67.5 
                 4.05 
                 15.31 
                 46.5 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 72.2 
               
               
                   
                 mixing them 
               
               
                   
                 50% 
                 135 
                 3.99 
                 3.33 
                 88.2 
               
               
                   
                 benziothiazolinone•fenamidone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fenamidone = 25:25) 
               
               
                 Example 
                 5% benziothiazolinone 
                 3.5 
                 3.73 
                 24.49 
                 7.1 
               
               
                 15 
                 microemulsion 
               
               
                   
                 20% fenamidone wettable powder 
                 131.5 
                 3.32 
                 4.62 
                 80.3 
               
               
                   
                 Anticipated control effect after 
                 — 
                 — 
                 — 
                 81.7 
               
               
                   
                 mixing them 
               
               
                   
                 62% 
                 135 
                 3.54 
                 3.38 
                 86.5 
               
               
                   
                 benziothiazolinone•fenamidone 
               
               
                   
                 wettable powder 
               
               
                   
                 (benziothiazolinone:fenamidone = 2:60) 
               
               
                 Water 
                 — 
                 — 
                 3.87 
                 27.35 
                 — 
               
               
                 control 
               
               
                 (CK) 
               
               
                   
               
             
          
         
       
     
         [0130]    The test results (in Table 23) show that the control effect of the combination of benziothiazolinone with benthiavalicarb-isopropyl, zoxamide, and fenamidone respectively on grape anthracnose is significantly improved, suggesting that the combination has an obvious synergistic effect on grape anthracnose.