PATENT DOCUMENT

Abstract:
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of an antibiotic drug or a pharmaceutical acceptable salt thereof. The antibiotic drug is selected from the group consisting of an aminoglycoside antibiotic drug, an anti-fungal antibiotic drug, a Cephalosporin antibiotic drug, a β-propionamide antibiotic drug, a chloramphenicol antibiotic drug, an erythromycin antibiotic drug, a penicillin antibiotic drug, and a tetracycline antibiotic drug. The cancer is selected from the group consisting of lung cancer, gastrointestinal tract cancer, colorectal cancer, prostate cancer, bladder cancer, cervical cancer, breast cancer, and blood cancer.

Full Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This is a National Phase Application filed under 35 U.S. C. 371 as a national stage of PCT/CN2015/092686 filed Oct. 23, 2015, an application claiming the benefit under 35 USC 119(e) to the following U.S. Provisional Applications No. 62/068,298 filed Oct. 24, 2014, the content of each of which is hereby incorporated by reference in its entirety. 
     
    
     FIELD OF THE INVENTION 
       [0002]    The present invention provides new clinical indication of several anti-biotic drugs, which were approved by FDA several years ago. The present invention demonstrates that several anti-biotic drugs can inhibit a variety of cancers effectively. 
       BACKGROUND OF THE INVENTION 
       [0003]    Cancer is the most popular disease cause of death in the world. The cancer patients are gradually increase yearly, therefore the treatment method of the cancer has become an important issue. The medical treatments of cancer can be classified as surgical treatment, radiation therapy, chemotherapy and target therapy. 
         [0004]    Generally, the cancer drug, whether chemotherapy drug or target therapy drug, is inhibit the cancer cells&#39; duplication and split to prevent the tumor growth and metastasis. In clinical treatment options, the combination of chemotherapies and several targeted therapies were selected; try to eliminate cancer cells more effectively, by means of different mechanisms. Furthermore, if the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure. 
         [0005]    Antibiotic drugs, are a kind of secondary metabolite compounds produced by microorganisms (including bacteria, fungi, antinomycetes genus) and chemically synthesized compounds or semisynthetic similar compounds, used to inhibit the growth of other types of microbial. It is a broader concept for antibiotics in definition, which includes anti-bacterial antibiotics, antifungal and other antibiotics against tiny pathogens. However, in clinical practice, the antibiotics often refer to anti-bacterial antibiotics. 
         [0006]    Based on the many years&#39; experience of inventors, the human cancer cells and normal cells often have different characteristics, the differences in patterns or mechanism variation might be seen as a foreign invader. The different cancel cells are located in different locations and the statuses of variations are related to the located environment. Thus, the inventors are the first person to propose the use of antibiotic drugs to inhibit the cancer cell growth. 
         [0007]    In contrast, these antibiotics have been used for decades and are recognized by FDA long time ago. These drugs already have been researched and analyzed to know the mechanism on human body. Therefore, the new invention would be time-saving and cost effective if these drugs applied in treating cancer. Besides, the treatment effect would be improved if these drugs are used to combine with other treating method. 
         [0008]    After U.S. Provisional Application of the present invention was applied, there was another professor researched the possibility of this invention. There are lots of studies proposed and confirmed the effect of the present invention recently. According to the hypothesis proposed by the professor (which is similar to Endosymbiotic Theory), which proved that the mitochondria ever was one kind of bacteria and had been endocrine by larger bacteria, and then lived within the larger cell symbiotically. Thus, the mitochondria is different with the other cell organelle, mitochondria has its own gene, and is similar to prokaryotes (such as bacteria). This difference might be designed as a therapeutic drug to treat the cancer cell individually. 
         [0009]    Recently, the drug design for cancer is mainly focused on development of high-specific drug molecules or target-based antibody. Averagely, only about five of 10,000 new drugs can successfully enter the phase I of clinical trials. 
         [0010]    Otherwise, the manufacturing of the drug is also a big problem. When the drug starting the clinical trials, there are lots of problems need to overcome, such as drug safety, patient selection, trial dose and other issues. Even the drug has approved by the FDA and sales on the market, there still possibly face the situation of the poor drug response in patients. Furthermore, if the cancer patients happen the drug resistance, that would reduce the effectiveness of the drugs and result in the medical treatment failure. Therefore, the new drug development is very difficult. 
       SUMMARY OF THE INVENTION 
       [0011]    To solve the above mentioned problem, the present invention provides a new usage of existing drugs through clinical trials of many kinds of drugs on new indications. 
         [0012]    The experiment results showed that the antibiotic drugs had no toxicity or only little toxicity on normal cells. However, there are more studies need to be test to know that whether the antibiotic drugs have selection preference between normal cells and cancer cells. Besides, not all the antibiotic drugs could inhibit the growth of cancer cells under same condition, there are still lots of problems need to be overcame. 
         [0013]    Term Definition 
         [0014]    The antibiotic drugs are classified as nine categories by the structures, includes: aminoglycosides antibiotic drug, anti-fungal antibiotic drug, Cephalosporin antibiotic drug, β-propionamide antibiotic drug, chloramphenicol antibiotic drug, erythromycin antibiotic drug, penicillin antibiotic drug, tetracyclines antibiotic drug and other antibiotic drugs. 
         [0015]    (1) Aminoglycosides antibiotic drug. Aminoglycoside is one class of antibiotics contains aminosugar substructures and cyclic amino alcohols, which is used to against Gram-negative bacteria and Pseudomonas aeruginosa clinically. The aminoglycosides antibiotic drugs which used in the present invention contains Amikacin sulfate, Amikacin hydrate, Netilmicin Sulfate. 
         [0016]    (2) Anti-fungal antibiotic drug. Anti-fungal antibiotic drug is an antibiotics category against fungus. The anti-fungal antibiotic drugs of the present invention contains Posaconazole, Artemisinin, Fluconazole, Ketoconazole, Voriconazole, Natamycin (Pimaricin), Clotrimazole (Canesten), Amphotericin B (Abelcet),Flucytosine (Ancobon), Amorolfine Hydrochloride, Terbinafine (Lamisil, Terbinex), Butoconazole nitrate, Chloroxine, Bifonazole, Tioconazole, Nystatin (Mycostatin), Miconazole nitrate, Liranaftate,Isoconazole nitrate (Travogen), Terbinafine hydrochloride (Lamisil), Ciclopirox ethanolamine, Caspofungin acetate, Naftifine HCl, Sertaconazole nitrate, Pyrithione zinc, Sulconazole Nitrate, Climbazole, Valnemulin HCl; 
         [0017]    (3) Cephalosporin antibiotic drug. Cephalosporins is part of a series of β-lactam antibiotics, and is classified as cephem together with cefotaxime. The Cephalosporin antibiotic drugs are used in the present invention contains: Cefdinir (Omnicef), Cefoperazone (Cefobid), Cefditoren pivoxil, Cephalexin (Cefalexin), Cefoselis sulfate, Ceftiofur hydrochloride, Cefaclor (Ceclor), Ceftazidime Pentahydrate, Moxalactam Disodium, Cephapirin Sodium 
         [0018]    (4) Beta-lactam antibiotic drug is a kind of very broad antibiotics, which features as penicillin and its derivatives, cephalosporins, monobactams, carbapenem and carbapenem enzyme inhibitors. Basically, all the β-lactam nucleus structure containing antibiotic drugs are classified as β-lactam antibiotics. It is the most widely used antibiotic drugs in conventional antibiotics. The Beta-lactam antibiotic drugs are used in the present invention contains Doripenem Hydrate, Meropenem, Aztreonam, Sulbactam, Sulbactam sodium (Unasyn), Biapenem; 
         [0019]    (5) Chloramphenicol antibiotic drug. Chloramphenicol antibiotic drug has a very wide range of activity, which can be used to against gram-positive bacteria, including most of methicillin-resistant staphylococcus aureus, gram-negative bacteria and anaerobes. The Chloramphenicol antibiotic drugs are used in the present invention contains: Gatifloxacin, Daptomycin, Sulfapyridine (Dagenan), Sulfameter (Bayrena), Chloramphenicol (Chloromycetin). 
         [0020]    (6) Penicillin antibiotic drug. Penicillin drug refers to a penicillanic containing molecule, which can destroy the cell walls of bacteria, can kill bacteria during the reproduction stage of bacteria, which is extracted from Penicillium. The Penicillin antibiotic drug belongs to β- lactam antibiotics. β-lactam antibiotic drugs include penicillins, cephalosporins, carbapenems, monocyclic and cephamycins. The Penicillin antibiotic drugs are used in the present invention contains Amoxicillin sodium (Amox), Ampicillin sodium, Carbenicillin disodium, Dicloxacillin Sodium, Ampicillin Trihydrate, Benzylpenicillin sodium, Mezlocillin Sodium, Piperacillin Sodium. 
         [0021]    (7) Erythromycin antibiotic drug is a macrolide antibiotic drug. The antibacterial range of the erythromycin antibiotic drug is similar to penicillin. The erythromycin antibiotic drug has been mainly used for penicillin resistant staphylococcus, streptococcus, diarrhea and other gastrointestinal reaction induced bacteria. The Erythromycin antibiotic drugs are used in the present invention contains Teicoplanin, Linezolid (Zyvox), Erythromycin (E-Mycin), Erythromycin Ethylsuccinate, Spiramycin, Tilmicosin, Azithromycin Dihydrate, Dirithromycin, Fidaxomicin; 
         [0022]    (8) Tetracyclines antibiotic drug. Tetracyclines antibiotic drug is a broad-spectrum antibiotic drugs family, which is named for the hydrogenated naphthacene nucleus. This class of drugs have broad spectrum and strong activity against Gram-negative bacteria, gram-positive bacteria, spirochetes, Chlamydia, Rickettsia, Mycoplasma, actinomycetes and amoeba. The Tetracyclines antibiotic drugs are used in the present invention contains Marbofloxacin, Moxifloxacin hydrochloride, Oxytetracycline (Terramycin), Tigecycline, Oxytetracycline dihydrate, Tetracycline HCl, Chlortetracycline HCl, Minocycline HCl, Rolitetracycline. 
         [0023]    The present invention provides a usage of several antibiotic drugs for preparation of cancer inhibition pharmaceutical composition (drug), wherein the pharmaceutical composition is composed of an effective dosage of anti-biotic drug and a pharmaceutical acceptable salt. 
         [0024]    The antibiotic drugs of the present invention are selected from aminoglycosides antibiotic drug, anti-fungal antibiotic drug, Cephalosporin antibiotic drug, β-propionamide antibiotic drug, chloramphenicol antibiotic drug, erythromycin antibiotic drug, penicillin antibiotic drug, tetracycline antibiotic drug and other antibiotic drugs. 
         [0025]    In one embodiment of the present invention, the aminoglycosides antibiotic drug is selected from Amikacin sulfate, Amikacin hydrate, and Netilmicin Sulfate. 
         [0026]    In one embodiment of the present invention, the anti-fungal antibiotic drug is selected from Posaconazole, Artemisinin, Fluconazole, Ketoconazole, Voriconazole, Natamycin (Pimaricin), Clotrimazole (Canesten), Amphotericin B (Abelcet), Flucytosine (Ancobon), Amorolfine Hydrochloride, Terbinafine (Lamisil, Terbinex), Butoconazole nitrate, Chloroxine, Bifonazole, Tioconazole, Nystatin (Mycostatin), Miconazole nitrate, Liranaftate, Isoconazole nitrate (Travogen), Terbinafine hydrochloride (Lamisil), Ciclopirox ethanolamine, Caspofungin acetate, Naftifine HCl, Sertaconazole nitrate, Pyrithione zinc, Sulconazole Nitrate, Climbazole, and Valnemulin HCl. 
         [0027]    In one embodiment of the present invention, the Cephalosporin antibiotic drug is selected from Cefdinir (Omnicef), Cefoperazone (Cefobid), Cefditoren pivoxil, Cephalexin (Cefalexin), Cefoselis sulfate, Ceftiofur hydrochlorid, Cefaclor (Ceclor), Ceftazidime Pentahydrate, Moxalactam Disodiu, and Cephapirin Sodium. 
         [0028]    In one embodiment of the present invention, the β-propionamide antibiotic drug is selected from Doripenem Hydrate, Meropenem, Aztreonam, Sulbactam, Sulbactam sodium (Unasyn), and Biapenem. 
         [0029]    In one embodiment of the present invention, the chloramphenicol antibiotic drug is selected from Gatifloxacin, Daptomycin, Sulfapyridine (Dagenan), Sulfameter (Bayrena), and Chloramphenicol (Chloromycetin). 
         [0030]    In one embodiment of the present invention, the penicillin antibiotic drug is selected from Amoxicillin sodium (Amox), Ampicillin sodium, Carbenicillin disodium, Dicloxacillin Sodium, Ampicillin Trihydrate, Benzylpenicillin sodium, Mezlocillin Sodium, Piperacillin Sodium. 
         [0031]    In one embodiment of the present invention, the erythromycin antibiotic drug is selected from Teicoplanin, Linezolid (Zyvox), Erythromycin (E-Mycin), Erythromycin Ethylsuccinate, Spiramycin, Tilmicosin, Azithromycin Dihydrate, Dirithromycin, and Fidaxomicin. 
         [0032]    In one embodiment of the present invention, the tetracyclines antibiotic drug is selected from Marbofloxacin, Moxifloxacin hydrochloride, Oxytetracycline (Terramycin), Tigecycline, Oxytetracycline dihydrate, Tetracycline HCl, Chlortetracycline HCl, Minocycline HCl, Rolitetracycline. 
         [0033]    In one embodiment of the present invention, the other antibiotic drug is selected from Norfloxacin (Norxacin), Enoxacin (Penetrex), Pefloxacin mesylate, Sparfloxacin, Levofloxacin (Levaquin), Sarafloxacin HCl, Nalidixic acid (NegGram), Lomefloxacin hydrochloride (Maxaquin), Enrofloxacin, Clinafloxacin (PD127391), Orbifloxacin, Clinafoxacin HCl, Piromidic Acid, Cinoxacin, Difloxacin HCl, Rifabutin (Mycobutin), Rifapentine (Priftin), Pyrazinamide (Pyrazinoic acid amide), Rifampin (Rifadin, Rimactane), Ethionamide, Rifaximin (Xifaxan), Protionamide (Prothionamide), Isoniazid (Tubizid), D-Cycloserine, Streptomycin sulfate, Clofazimine, Nitrofurazone, Sulfanilamide, Sulfadiazine, Metronidazole (Flagyl), Sulfamethoxazole, Sulfisoxazole, Sulfamethizole (Proklar), Sulfadimethoxine, Clindamycin phosphate, Fenbendazole (Panacur), Sulfadoxine (Sulphadoxine), Secnidazole (Flagentyl), Clindamycin palmitate HCl, Clindamycin, Sulfathiazole, Trimethoprim, Sulfamerazine, Pentamidine, Colistin Sulfate (polypeptide), toltrazuril, tinidazoleMequinol, Bacitracin, Cetylpyridinium Chloride, Sulfaguanidine, Paromomycin Sulfate, Domiphen Bromide, Chlorquinaldol, Furaltadone HCl, Primaquine Diphosphate, Carbadox, Colistimethate Sodium, Meclocycline Sulfosalicylate, Thiostrepton, Bekanamycin, Clofoctol, Ritonavir, Entecavir hydrate, Artemisinin, Megestrol Acetate, Lansoprazole, Lopinavir (ABT-378), Ondansetron hydrochloride, Resveratrol, Stavudine, Tenofovir Disoproxil Fumarate, Tenofovir (Viread), Cidofovir (Vistide), Telaprevir (VX-950), Saxagliptin (BMS-477118,Onglyza), Darunavir Ethanolate (Prezista), Docosanol (Abreva), Amprenavir (Agenerase), Telbivudine (Sebivo, Tyzeka), Hydrocortisone (Cortisol), Didanosine (Videx), Emtricitabine (Emtriva), Lamivudine (Epivir), Adefovir Dipivoxil (Preveon, Hepsera), Zalcitabine, Prednisolone (Hydroretrocortine), Nevirapine (Viramune), Trifluridine (Viroptic), Vidarabine (Vira-A), Acyclovir (Aciclovir), Albendazole Oxide (Ricobendazole), Chenodeoxycholic acid, Valaciclovir HCl, Ganciclovir, Idoxuridine, Crystal violet, Rimantadine (Flumadine), Taurine (organic acid), Diclazuril (anticoccidial drug), Rebamipide, Orphenadrine citrate (Norflex), Terazosin HCl (Hytrin), Lafutidine, Dextrose, BIBR-1048 (Dabigatran), Rosuvastatin calcium (Crestor), Ammonium Glycyrrhizinate (AMGZ), Amfebutamone (Bupropion), Clonidine hydrochloride (Catapres), Fluocinolone acetonide (Flucort-N), Loperamide hydrochloride, Mycophenolic (Mycophenolate), Olanzapine (Zyprexa), Racecadotril (Acetorphan), Rosiglitazone maleate, Salbutamol sulfate (Albuterol), Tenoxicam (Mobiflex), Vardenafil (Vivanza), Dopamine hydrochloride (Inotropin), Ritodrine hydrochloride (Yutopar), Riboflavin (Vitamin B2), Clomipramine hydrochloride (Anafranil), Tiotropium Bromide hydrate, Isoprenaline hydrochloride, Medroxyprogesterone acetate, Xylometazoline HCl, Phenacetin, Trazodone hydrochloride (Desyrel), Brompheniramine, Acemetacin (Emflex), Dabrafenib (GSK2118436), Paroxetine HCl, Zanamivir (Relenza), Niflumic acid, Medetomidine HCl, Diclofenac Potassium, Ulipristal, Indacaterol Maleate, Biotin (Vitamin B7), Sodium salicylate, Methylthiouracil, Darifenacin HBr, Benztropine mesylate, Abacavir sulfate, Antipyrine, Amitriptyline HCl, Azatadine dimaleate, Triflusal, Pemirolast (BMY 26517) potassium, Homatropine Bromide, Carbimazole, Spironolactone, Ropivacaine HCl, Escitalopram oxalate, Bismuth Subcitrate Potassium(mineral), Chlorpropamide, Nifuroxazide, Penciclovir, Salicylanilide, Betamipron, Ethacridine lactate monohydrate (aromatic compound), Aminothiazole, Florfenicol, Cetrimonium Bromide (antiseptic), Thonzonium Bromide(detergent), and Pasiniazid. 
         [0034]    In one embodiment of the present invention, the cancer is selected from lung cancer, gastrointestinal tract cancer, colorectal cancer, prostate cancer, bladder cancer, cervical cancer, breast cancer and blood cancer. 
         [0035]    In one embodiment of the present invention, the effective dose of anti-biotic drug is from 20 mg/kg/day to 500 mg/kg/day. 
         [0036]    The cancer drugs often cost hundreds of thousands to millions dollars nowadays. On the other hand, the cheaper antibiotic drugs are used for a long time. If the efficacy of anti-tumor treatment with using these antibiotic drugs is further confirmed, the new indication of the antibiotic drugs would bring hopes for the patients who cannot afford expensive drugs. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0037]      FIG. 1  shows the results of the inhibitory effect of the cancer cells by antibiotic drugs. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0038]    Cell Culture 
         [0039]    Subculture the different types of cancer cells. The cancer cells includes lung cancer, gastric cancer, hepatic cancer, colon cancer, skin cancer, cervical cancer, prostate cancer, bladder cancer, breast cancer, leukemia, pancreatic cancer, ovarian cancer, tongue cancer, osteosarcoma, and renal cancer. The normal cells used in the control group included renal cell (HEK293), HFW human fibroblast cell line, human bronchial epithelial cell line BEAS-2B. (as shown in Table 1). Cancer cell lines were cultured in different culture medium according to different characteristics (as shown in Table 1). The cell numbers were counted and reseed as 2×10 6 in cell culture plate/flask. Then, the culture medium for culturing the cell lines was added to a volume of 10 ml, and the cells were cultured for 2-3 days. Then, the cells were suspended for loading into 96-well plates. The cell number was 3000 cells and the volume of the culture medium was 100 ul each well. 
         [0000]    
       
         
               
             
               
               
               
               
             
           
               
                 TABLE 1 
               
               
                   
               
               
                 Cancer cell lines and the culture medium 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 No 
                 Cancer type 
                 Cancer cell type 
                 medium 
               
               
                   
               
               
                 1 
                 Lung cancer 
                 HI650 (Lung Adenocarcinoma) 
                 RPMI-1640 
               
               
                   
                   
                 A549 (Lung Adenocarcinoma) 
                 DMEM 
               
               
                 2 
                 gastric cancer 
                 AGS (Gastric Adenocarcinoma) 
                 RPMI-1640 
               
               
                   
                   
                 MKN-45 (Gastric Adenocarcinoma) 
                 RPMI-1640 
               
               
                 3 
                 hepatic cancer 
                 HepG2 (Hepatocellular Carcinoma) 
                 DMEM 
               
               
                   
                   
                 Hep3B (hepatocellular carcinoma) 
                 DMEM 
               
               
                 4 
                 colon cancer 
                 HCT116 (p53+) (Colorectal Carcinoma) 
                 DMEM 
               
               
                   
                   
                 LoVo (Colorectal Adenocarcinoma) 
                 DMEM 
               
               
                 5 
                 skin cancer 
                 A375 (Amelanotic Melanoma) 
                 DMEM 
               
               
                   
                   
                 BCC (basal cell carcinoma) 
                 DMEM 
               
               
                 6 
                 cervical cancer 
                 HeLa (Cervix Adenocarcinoma) 
                 DMEM 
               
               
                   
                   
                 C-33A (Cervical carcinoma) BCRC60554 
                 MEM 
               
               
                 7 
                 prostate cancer 
                 PC3 (p53−) (Prostate Adenocarcinoma) 
                 DMEM 
               
               
                   
                   
                 LNCaP clone FGC (LNCap.FGC) 
                 RPMI-1640 
               
               
                 8 
                 bladder cancer 
                 TSGH-8301 (Urinary Bladder 
                 RPMI-1640 
               
               
                   
                   
                 Carcinoma) 
               
               
                   
                   
                 T24 
                 RPMI-1640 
               
               
                 9 
                 breast cancer 
                 MCF7 (Mammary Gland, 
                 DMEM 
               
               
                   
                   
                 Adenocarcinoma) 
               
               
                   
                   
                 MDA-MB-231 (Mammary Gland, 
                 DMEM 
               
               
                   
                   
                 Adenocarcinoma) 
               
               
                 10 
                 pancreatic cancer 
                 BxPC-3 
                 RPMI-1640 
               
               
                   
                   
                 AsPC-1 
                 RPMI-1640 
               
               
                 11 
                 ovarian Cancer 
                 NIH: OVCAR-3 
                 RPMI-1640 
               
               
                   
                   
                 TOV-21G 
                 RPMI-1640 
               
               
                 12 
                 tongue cancer 
                 SAS (Tongue squamous cell carcinoma) 
                 DMEM 
               
               
                 13 
                 osteosarcoma 
                 U-2OS 
                 DMEM 
               
               
                 14 
                 renal Cancer 
                 786-O (Renal adenocarcinoma) BCRC 
                 RPMI-1640 
               
               
                   
                   
                 60243 
               
               
                 19 
                 leukemia 
                 HL-60 (Acute Promyelocytic Leukemia) 
                 RPMI 
               
               
                   
               
               
                 No 
                 Control cell type 
                 Cell line 
                 medium 
               
               
                   
               
               
                 20 
                 renal cell 
                 HEK293 (Kidney) 
                 DMEM 
               
               
                 21 
                 fibroblast cell 
                 HFW 
                 DMEM 
               
               
                 22 
                 lung epithelial cells 
                 BEAS-2B (Lung Epithelial) 
                 RPMI-1640 
               
               
                   
               
             
          
         
       
     
         [0040]    Cell Viability Analysis 
         [0041]    Removing the original culture medium from 96-well plate. Then add 100 μl of commercially drug at a concentration of 10 μM per well. After 72 hours, add the diluted WST-1 reagent to the well with 100 μ/well, and the diluted WST-1 reagent was acquired from the dilution of 9:1 medium and WST-1 stock reagent. Finally, the total volume of each well are 200 μl/well. Culture the 96-well plate at 37° C. for 30 to 90 minutes. Detecting and calculating the survival rate of each cancer cell lines with an ELISA reader at OD450 nm. The lower viability of cancer cells represents better inhibition effect via the drugs. Otherwise, the higher viability of cancer cells represents worse inhibition effect via the drugs. 
         [0042]    Growth Inhibitory Effects on Cancer Cell Lines by Various Antibiotic Drugs in the Present Invention 
         [0043]    The antibiotic drugs are classified 9 categories. So, the antibiotic drugs including aminoglycosides antibiotic drug, anti-fungal antibiotic drug, Cephalosporin antibiotic drug, β-propionamide antibiotic drug, chloramphenicol antibiotic drug, erythromycin antibiotic drug, penicillin antibiotic drug, tetracycline antibiotic drug and other antibiotic drugs were tested and analyze the inhibit effect on cancer cell lines growth by cell viability analysis. 
         [0044]    The test results showed obviously that growth inhibitory effects on cancer cell lines by various antibiotic drugs (as shown in Table 2). 
         [0000]    
       
         
               
             
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 The antibiotic drugs which do not have significant 
               
               
                 inhibitory effect to cancer cells 
               
             
          
           
               
                 Antibiotic drugs 
                 Inhibitory effect on cancer cell line 
               
               
                   
               
               
                 Artemisinin 
                 0 
               
               
                 Cefoselis sulfate 
                 0 
               
               
                 Doripenem Hydrate 
                 0 
               
               
                 Marbofloxacin 
                 0 
               
               
                 Moxifloxacin hydrochloride 
                 0 
               
               
                 Norfloxacin (Norxacin) 
                 0 
               
               
                 Flucytosine (Ancobon) 
                 0 
               
               
                 Amorolfine Hydrochloride 
                 0 
               
               
                 Chloramphenicol (Chloromycetin) 
                 0 
               
               
                 Hydrocortisone (Cortisol) 
                 0 
               
               
                 Terbinafme (Lamisil, Terbinex) 
                 0 
               
               
                 Valaciclovir HCl 
                 0 
               
               
                 Ganciclovir 
                 0 
               
               
                 Sulfamethizole (Proklar) 
                 0 
               
               
                 Sulbactam 
                 0 
               
               
                 Sulphadimethoxine 
                 0 
               
               
                 Rimantadine (Flumadine) 
                 0 
               
               
                 Racecadotril (Acetorphan) 
                 0 
               
               
                 Rosiglitazone maleate 
                 0 
               
               
                 Salbutamol sulfate (Albuterol) 
                 0 
               
               
                 Sulfadoxine (Sulphadoxine) 
                 0 
               
               
                 Tenoxicam (Mobiflex) 
                 0 
               
               
                 Ritodrine hydrochloride (Yutopar) 
                 0 
               
               
                 Brompheniramine 
                 0 
               
               
                 Acemetacin (Emflex) 
                 0 
               
               
                 Amikacin hydrate 
                 0 
               
               
                 Trimethoprim 
                 0 
               
               
                 Biotin (Vitamin B7) 
                 0 
               
               
                 Sulfamerazine 
                 0 
               
               
                 Sodium salicylate 
                 0 
               
               
                 Methylthiouracil 
                 0 
               
               
                 Benztropine mesylate 
                 0 
               
               
                 Triflusal 
                 0 
               
               
                 Carbimazole 
                 0 
               
               
                 Netilmicin Sulfate 
                 0 
               
               
                 Ropivacaine HCl 
                 0 
               
               
                 Erythromycin Ethylsuccinate 
                 0 
               
               
                 Escitalopram oxalate 
                 0 
               
               
                 Tinidazole 
                 0 
               
               
                 Bismuth Subcitrate Potassium 
                 0 
               
               
                 Sulfaguanidine 
                 0 
               
               
                 Mezlocillin Sodium 
                 0 
               
               
                 Penciclovir 
                 0 
               
               
                 Salicylanilide 
                 0 
               
               
                 Florfenicol 
                 0 
               
               
                 Dirithromycin 
                 0 
               
               
                 Piromidic Acid 
                 0 
               
               
                   
               
             
          
         
       
     
         [0045]    Besides, the inhibitory effect of all kinds antibiotic drugs on cancer cells are not the same (shown as  FIG. 1 ). According to the experiment of the present invention, the Ritonavir, Entecavir hydrate, Posaconazole, Artemisinin, Megestrol Acetate, Fluconazole, Gatifloxacin, Ketoconazole, Lansoprazole, Acitretin, Biapenem, Cefoselis sulfate, Daptomycin, Doripenem Hydrate, Lopinavir (ABT-378), Meropenem, Ondansetron hydrochloride (Zofran), Resveratrol, Stavudine, Teicoplanin, Tenofovir Disoproxil Fumarate, Tenofovir (Viread), Tigecycline, Linezolid (Zyvox), Voriconazole, Marbofloxacin, Moxifloxacin hydrochloride, Cefaclor (Ceclor), Cephalexin (Cefalexin), Aztreonam (Azactam, Cayston), Norfloxacin (Norxacin), Cidofovir (Vistide), Natamycin (Pimaricin), Telaprevir (VX-950), Saxagliptin (BMS-477118,Onglyza), Cefdinir (Omnicef), Clotrimazole (Canesten), Cefoperazone (Cefobid), Sulfapyridine (Dagenan), Sulfameter (Bayrena), Darunavir Ethanolate (Prezista), Erythromycin (E-Mycin), Amphotericin B (Abelcet), Docosanol (Abreva), Amprenavir (Agenerase), Nitrofurazone (Nitrofural), Telbivudine (Sebivo, Tyzeka), Flucytosine (Ancobon), Amorolfine Hydrochloride, Chloramphenicol (Chloromycetin), Sulfanilamide, Hydrocortisone (Cortisol), Didanosine (Videx), Emtricitabine (Emtriva), Lamivudine (Epivir), Adefovir Dipivoxil (Preveon, Hepsera), Zalcitabine, Terbinafine (Lamisil, Terbinex), Prednisolone (Hydroretrocortine), Rifabutin (Mycobutin), Nevirapine (Viramune), Enoxacin (Penetrex), Rifapentine (Priftin), Pyrazinamide (Pyrazinoic acid amide), Rifampin (Rifadin, Rimactane), Cefditoren pivoxil, Sulfadiazine, Oxytetracycline (Terramycin), Ethionamide, Trifluridine (Viroptic), Vidarabine (Vira-A), Rifaximin (Xifaxan), Acyclovir (Aciclovir), Butoconazole nitrate, Albendazole Oxide (Ricobendazole), Chloroxine, Chenodeoxycholic acid, Bifonazole, Pefloxacin mesylate, Valaciclovir HCl, Ganciclovir, Protionamide (Prothionamide), Idoxuridine, Sparfloxacin, Metronidazole (Flagyl), Tioconazole, Sulfamethoxazole, Sulfisoxazole, Crystal violet, Nystatin (Mycostatin), Isoniazid (Tubizid), Levofloxacin (Levaquin), Miconazole nitrate, Sulfamethizole (Proklar), Sulbactam, Sulphadimethoxine, Rimantadine (Flumadine), Sarafloxacin HCl, Liranaftate, D-Cycloserine, Taurine, Diclazuril, Rebamipide, Clindamycin phosphate, Oxytetracycline dihydrate, Orphenadrine citrate (Norflex), Terazos in HCl (Hytrin), Lafutidine, Dextrose (D-glucose), BIBR-1048 (Dabigatran), Rosuvastatin calcium (Crestor), Nalidixic acid (NegGram), Ammonium Glycyrrhizinate (AMGZ), Amfebutamone (Bupropion), Clonidine hydrochloride (Catapres), Fenbendazole (Panacur), Fluocinolone acetonide (Flucort-N), Loperamide hydrochloride, Mycophenolic (Mycophenolate), Olanzapine (Zyprexa), Racecadotril (Acetorphan), Rosiglitazone maleate, Salbutamol sulfate (Albuterol), Sulfadoxine (Sulphadoxine), Tenoxicam (Mobiflex), Vardenafil (Vivanza), Dopamine hydrochloride (Inotropin), Ritodrine hydrochloride (Yutopar), Isoconazole nitrate (Travogen), Secnidazole (Flagentyl), Lomefloxacin hydrochloride (Maxaquin), Riboflavin (Vitamin B2), Clomipramine hydrochloride (Anafranil), Ceftiofur hydrochloride, Tiotropium Bromide hydrate, Sulbactam sodium (Unasyn), Terbinafine hydrochloride (Lamisil), Amoxicillin sodium (Amox), Isoprenaline hydrochloride, Medroxyprogesterone acetate, Streptomycin sulfate, Tetracycline HCl, Xylometazoline HCl, Phenacetin, Trazodone hydrochloride (Desyrel), Brompheniramine, Clindamycin palmitate HCl, Acemetacin (Emflex), Dabrafenib (GSK2118436), Clindamycin, Paroxetine HCl, Zanamivir (Relenza), Niflumic acid, Ciclopirox ethanolamine, Enrofloxacin, Medetomidine HCl, Diclofenac Potassium, Amikacin sulfate, Caspofungin acetate, Ulipristal, Indacaterol Maleate, Sulfathiazole, Amikacin hydrate, Trimethoprim, Biotin (Vitamin B7), Sulfamerazine, Sodium salicylate, Methylthiouracil, Darifenacin HBr, Naftifine HCl, Sertaconazole nitrate, Benztropine mesylate, Abacavir sulfate, Ampicillin sodium, Antipyrine, Carbenicillin disodium, Amitriptyline HCl, Azatadine dimaleate, Triflusal, Clinafloxacin (PD127391), Pentamidine, Pemirolast (BMY 26517) potassium, Homatropine Bromide, Colistin Sulfate, toltrazuril, Carbimazole, Netilmicin Sulfate, Spironolactone, Ropivacaine HCl, Erythromycin Ethylsuccinate, Escitalopram oxalate, tinidazole, Pyrithione zinc, Mequinol, Spiramycin, Bismuth Subcitrate Potassium, Clofazimine, Dicloxacillin Sodium, Sulconazole Nitrate, Tilmicosin, Bacitracin, Azithromycin Dihydrate, Ampicillin Trihydrate, Orbifloxacin, Chlortetracycline HCl, Benzylpenicillin sodium, Chlorpropamide, Cetylpyridinium Chloride, Sulfaguanidine, Climbazole, Mezlocillin Sodium, Nifuroxazide, Paromomycin Sulfate, Penciclovir, Domiphen Bromide, Salicylanilide, Betamipron, Chlorquinaldol, Ethacridine lactate monohydrate, Aminothiazole, Florfenicol, Furaltadone HCl, Dirithromycin, Valnemulin HCl, Piperacillin Sodium, Minocycline HCl, Fidaxomicin, Primaquine Diphosphate, Cetrimonium Bromide, Carbadox, Ceftazidime Pentahydrate, Clinafoxacin HCl, Colistimethate Sodium, Meclocycline Sulfosalicylate, Moxalactam Disodium, Piromidic Acid, Rolitetracycline, Thiostrepton, Thonzonium Bromide, Cinoxacin, Bekanamycin, Difloxacin HCl, Cephapirin Sodium, Clofoctol, Pasiniazid showed significant inhibition effect on different cancer cell lines (shown as Table 3). 
         [0046]    Although the present invention has been described in terms of specific exemplary embodiments and examples, it will be appreciated that the embodiments disclosed herein are for illustrative purposes only and various modifications and alterations might be made by those skilled in the art without departing from the spirit and scope of the invention as set forth in the following claims. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                 The results of antibiotic drug for inhibiting cancer cell lines 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Drug Name 
                 A375 
                 HCT116 
                 HepG2 
                 HeLa 
                 AGS 
                 H1650 
                 MKN-45 
                 TSGH 
                 A549 
                 MCF7 
                 PC3 
                 LoVo 
                 HL-60 
               
               
                   
               
               
                 Ritonavir 
                 69.9 
                 58.8 
                 65.4 
                 48.6 
                 69.9 
                 40.8 
                 49.7 
                 71.4 
                 86.8 
                 100.8 
                 61.5 
                 82.3 
                 106.7 
               
               
                 Entecavir hydrate 
                 98.6 
                 87.1 
                 98.8 
                 99.4 
                 46.4 
                 80.8 
                 59.7 
                 53.0 
                 57.4 
                 58.6 
                 81.2 
                 91.6 
                 74.1 
               
               
                 Posaconazole 
                 49.8 
                 65.4 
                 87.2 
                 75.8 
                 42.7 
                 67.0 
                 52.0 
                 51.3 
                 42.9 
                 63.6 
                 45.3 
                 73.7 
                 71.3 
               
               
                 Artemisinin 
                 88.9 
                 95.5 
                 116.5 
                 120.1 
                 87.7 
                 106.4 
                 117.1 
                 63.6 
                 98.7 
                 150.6 
                 92.5 
                 103.5 
                 146.0 
               
               
                 Megestrol Acetate 
                 80.8 
                 59.5 
                 88.9 
                 78.6 
                 84.7 
                 56.0 
                 74.8 
                 74.3 
                 1116.1 
                 109.9 
                 80.3 
                 108.9 
                 94.0 
               
               
                 Fluconazole 
                 76.9 
                 42.9 
                 97.4 
                 79.2 
                 50.2 
                 45.3 
                 76.2 
                 66.1 
                 125.2 
                 101.1 
                 97.7 
                 102.1 
                 105.7 
               
               
                 Gatifloxacin 
                 63.3 
                 57.4 
                 65.6 
                 84.1 
                 71.4 
                 47.2 
                 84.2 
                 65.0 
                 96.0 
                 130.2 
                 82.2 
                 98.3 
                 100.5 
               
               
                 Ketoconazole 
                 49.2 
                 38.1 
                 88.7 
                 84.3 
                 65.7 
                 46.1 
                 77.0 
                 107.3 
                 75.7 
                 118.0 
                 80.1 
                 90.3 
                 88.3 
               
               
                 Lansoprazole 
                 60.6 
                 57.9 
                 72.3 
                 53.6 
                 71.5 
                 45.5 
                 74.5 
                 109.0 
                 84.5 
                 141.3 
                 94.2 
                 96.1 
                 78.6 
               
               
                 Acitretin 
                 61.4 
                 47.9 
                 72.6 
                 52.7 
                 68.1 
                 43.8 
                 78.5 
                 126.6 
                 69.1 
                 118.6 
                 92.5 
                 83.6 
                 96.7 
               
               
                 Biapenem 
                 60.4 
                 78.3 
                 66.4 
                 54.0 
                 75.1 
                 42.2 
                 81.5 
                 117.3 
                 90.1 
                 135.6 
                 80.3 
                 88.7 
                 95.5 
               
               
                 Cefoselis sulfate 
                 106.2 
                 96.2 
                 111.9 
                 103.7 
                 78.2 
                 88.4 
                 100.9 
                 77.7 
                 99.7 
                 83.5 
                 97.8 
                 91.9 
                 95.2 
               
               
                 Daptomycin 
                 81.2 
                 90.8 
                 95.9 
                 113.6 
                 63.0 
                 76.3 
                 92.1 
                 56.8 
                 74.0 
                 85.3 
                 79.7 
                 90.9 
                 108.3 
               
               
                 Doripenem Hydrate 
                 100.8 
                 95.6 
                 106.5 
                 121.9 
                 66.5 
                 78.5 
                 110.6 
                 79.9 
                 70.9 
                 99.8 
                 84.2 
                 95.2 
                 91.2 
               
               
                 Lopinavir (ABT-378) 
                 83.1 
                 81.8 
                 93.1 
                 115.5 
                 55.4 
                 53.1 
                 74.2 
                 82.2 
                 63.8 
                 77.9 
                 68.0 
                 85.1 
                 92.4 
               
               
                 Meropenem 
                 65.1 
                 97.1 
                 99.3 
                 110.9 
                 68.3 
                 55.4 
                 84.9 
                 132.5 
                 46.0 
                 68.1 
                 70.7 
                 87.3 
                 102.5 
               
               
                 Ondansetron HCl (Zofran) 
                 57.7 
                 73.6 
                 98.3 
                 86.2 
                 59.7 
                 60.9 
                 70.8 
                 88.7 
                 47.1 
                 64.5 
                 66.0 
                 82.4 
                 97.3 
               
               
                 Resveratrol 
                 53.0 
                 74.3 
                 101.1 
                 108.2 
                 47.9 
                 54.6 
                 91.8 
                 85.3 
                 72.5 
                 71.8 
                 75.0 
                 83.2 
                 76.4 
               
               
                 Stavudine 
                 56.1 
                 73.1 
                 97.1 
                 98.1 
                 39.2 
                 50.2 
                 66.8 
                 111.5 
                 38.9 
                 56.6 
                 73.5 
                 70.7 
                 96.0 
               
               
                 Teicoplanin 
                 64.1 
                 64.4 
                 94.7 
                 86.5 
                 58.7 
                 47.6 
                 70.0 
                 81.7 
                 51.7 
                 64.2 
                 83.5 
                 82.1 
                 96.8 
               
               
                 Tenofovir Disoproxil  
                 67.1 
                 68.4 
                 93.7 
                 85.7 
                 54.7 
                 50.9 
                 71.6 
                 88.2 
                 47.0 
                 68.7 
                 66.9 
                 75.8 
                 93.4 
               
               
                 Fumarate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Tenofovir (Viread) 
                 60.6 
                 81.8 
                 99.0 
                 95.0 
                 67.0 
                 55.6 
                 70.9 
                 92.4 
                 47.7 
                 71.1 
                 68.1 
                 85.9 
                 97.6 
               
               
                 Tigecycline 
                 52.2 
                 80.0 
                 101.6 
                 100.7 
                 49.4 
                 53.1 
                 89.2 
                 98.5 
                 55.9 
                 71.1 
                 83.0 
                 82.4 
                 97.6 
               
               
                 Linezolid (Zyvox) 
                 57.6 
                 76.7 
                 91.3 
                 93.7 
                 70.8 
                 51.3 
                 65.9 
                 58.2 
                 40.2 
                 66.3 
                 67.0 
                 91.0 
                 129.4 
               
               
                 Voriconazole 
                 102.3 
                 113.3 
                 101.1 
                 92.6 
                 86.1 
                 102.1 
                 104.1 
                 53.9 
                 82.9 
                 90.1 
                 97.0 
                 101.3 
                 94.3 
               
               
                 Marbofloxacin 
                 86.8 
                 95.1 
                 95.6 
                 88.2 
                 81.2 
                 80.3 
                 112.0 
                 91.6 
                 83.8 
                 92.3 
                 78.4 
                 107.9 
                 104.8 
               
               
                 Moxifloxacin  
                 94.0 
                 90.1 
                 95.2 
                 92.0 
                 77.1 
                 70.9 
                 89.0 
                 75.7 
                 95.5 
                 90.3 
                 69.1 
                 102.2 
                 97.1 
               
               
                 hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cefaclor (Ceclor) 
                 67.5 
                 93.4 
                 108.1 
                 86.7 
                 41.9 
                 62.3 
                 97.0 
                 81.6 
                 61.0 
                 90.6 
                 70.1 
                 88.2 
                 112.1 
               
               
                 Cephalexin (Cefalexin) 
                 92.7 
                 107.2 
                 109.0 
                 76.2 
                 59.6 
                 71.2 
                 94.9 
                 69.2 
                 80.6 
                 96.1 
                 57.5 
                 85.9 
                 95.2 
               
               
                 Aztreonam (Azactam,  
                 88.6 
                 80.4 
                 110.8 
                 87.2 
                 40.9 
                 48.6 
                 60.5 
                 52.3 
                 56.9 
                 68.6 
                 55.2 
                 76.3 
                 113.0 
               
               
                 Cayston) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Norfloxacin (Norxacin) 
                 73.8 
                 99.0 
                 90.5 
                 78.7 
                 63.8 
                 75.0 
                 68.9 
                 75.9 
                 84.8 
                 94.8 
                 72.2 
                 88.0 
                 87.7 
               
               
                 Cidofovir (Vistide) 
                 82.6 
                 88.0 
                 97.2 
                 82.1 
                 39.6 
                 53.3 
                 56.9 
                 49.8 
                 58.3 
                 78.3 
                 63.9 
                 82.3 
                 112.2 
               
               
                 Natamycin (Pimaricin) 
                 82.1 
                 89.3 
                 95.3 
                 93.5 
                 40.9 
                 57.0 
                 67.1 
                 84.9 
                 62.6 
                 83.2 
                 70.0 
                 84.8 
                 106.9 
               
               
                 Telaprevir (VX-950) 
                 130.7 
                 81.0 
                 100.4 
                 84.0 
                 49.2 
                 51.6 
                 48.0 
                 50.2 
                 49.3 
                 61.6 
                 50.0 
                 73.7 
                 111.4 
               
               
                 Saxagliptin (BMS- 
                 90.8 
                 81.2 
                 94.9 
                 81.2 
                 40.9 
                 49.5 
                 49.4 
                 56.9 
                 43.1 
                 55.2 
                 65.8 
                 80.0 
                 108.5 
               
               
                 477118, Onglyza) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cefdinir (Omnicef) 
                 92.5 
                 94.2 
                 105.5 
                 86.4 
                 79.1 
                 93.6 
                 70.5 
                 35.6 
                 97.0 
                 55.1 
                 134.7 
                 110.7 
                 104.1 
               
               
                 Clotrimazole (Canesten) 
                 81.4 
                 67.0 
                 101.8 
                 90.0 
                 85.7 
                 75.9 
                 53.9 
                 50.8 
                 85.5 
                 56.8 
                 69.3 
                 94.1 
                 106.4 
               
               
                 Cefoperazone (Cefobid) 
                 90.0 
                 85.3 
                 100.8 
                 91.7 
                 98.6 
                 98.4 
                 51.6 
                 60.3 
                 76.5 
                 50.1 
                 104.3 
                 105.3 
                 111.1 
               
               
                 Sulfapyridine (Dagenan) 
                 77.2 
                 82.2 
                 98.9 
                 71.2 
                 71.9 
                 69.5 
                 53.8 
                 64.6 
                 64.5 
                 54.7 
                 107.8 
                 84.6 
                 111.1 
               
               
                 Sulfameter (Bayrena) 
                 89.2 
                 81.5 
                 95.5 
                 78.4 
                 67.4 
                 84.8 
                 58.6 
                 78.6 
                 59.0 
                 51.7 
                 90.2 
                 89.9 
                 109.5 
               
               
                 Darunavir Ethanolate  
                 79.9 
                 70.0 
                 90.5 
                 79.2 
                 75.4 
                 82.2 
                 62.6 
                 46.7 
                 72.6 
                 43.9 
                 87.8 
                 98.8 
                 114.9 
               
               
                 (Prezista) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Erythromycin (E-Mycin) 
                 100.8 
                 77.7 
                 93.5 
                 93.0 
                 27.7 
                 90.4 
                 53.2 
                 42.6 
                 63.8 
                 45.2 
                 86.0 
                 85.5 
                 110.7 
               
               
                 Amphotericin B (Abelcet) 
                 98.9 
                 57.4 
                 90.3 
                 84.5 
                 28.5 
                 61.2 
                 44.0 
                 56.0 
                 45.0 
                 38.9 
                 66.9 
                 66.5 
                 115.6 
               
               
                 Docosanol (Abreva) 
                 84.6 
                 65.7 
                 83.6 
                 76.9 
                 40.6 
                 69.3 
                 52.4 
                 54.8 
                 44.0 
                 39.1 
                 70.2 
                 89.4 
                 115.7 
               
               
                 Amprenavir (Agenerase) 
                 77.6 
                 68.0 
                 90.9 
                 67.5 
                 58.8 
                 69.5 
                 52.1 
                 57.0 
                 53.7 
                 37.0 
                 80.4 
                 77.4 
                 111.0 
               
               
                 Nitrofurazone (Nitrofural) 
                 54.9 
                 65.0 
                 82.4 
                 55.4 
                 28.0 
                 61.1 
                 42.0 
                 32.5 
                 44.3 
                 35.3 
                 53.8 
                 64.9 
                 85.6 
               
               
                 Telbivudine (Sebivo,  
                 57.5 
                 51.2 
                 94.4 
                 51.9 
                 27.5 
                 67.5 
                 36.2 
                 50.4 
                 43.7 
                 31.9 
                 53.6 
                 65.3 
                 100.5 
               
               
                 Tyzeka) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Flucytosine (Ancobon) 
                 101.5 
                 84.0 
                 93.2 
                 80.9 
                 70.7 
                 92.1 
                 72.9 
                 93.9 
                 91.4 
                 75.3 
                 107.6 
                 107.5 
                 102.2 
               
               
                 Amorolfine Hydrochloride 
                 98.6 
                 86.5 
                 91.6 
                 84.6 
                 94.4 
                 79.6 
                 65.1 
                 88.5 
                 104.5 
                 104.3 
                 103.7 
                 99.7 
                 103.5 
               
               
                 Chloramphenicol 
                 114.0 
                 92.7 
                 93.6 
                 85.0 
                 90.6 
                 75.6 
                 66.8 
                 83.5 
                 96.3 
                 89.1 
                 119.5 
                 100.8 
                 105.4 
               
               
                 (Chloromycetin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Sulfanilamide 
                 84.6 
                 98.9 
                 100.7 
                 82.1 
                 65.3 
                 66.7 
                 59.1 
                 76.5 
                 82.7 
                 104.9 
                 111.0 
                 85.0 
                 112.2 
               
               
                 Hydrocortisone (Cortisol) 
                 87.6 
                 97.4 
                 108.8 
                 86.1 
                 77.5 
                 66.1 
                 81.3 
                 125.3 
                 73.6 
                 76.9 
                 103.8 
                 83.3 
                 104.8 
               
               
                 Didanosine (Videx) 
                 77.2 
                 130.4 
                 119.1 
                 80.3 
                 48.7 
                 64.2 
                 62.0 
                 76.7 
                 67.5 
                 78.4 
                 76.4 
                 95.1 
                 126.5 
               
               
                 Emtricitabine (Emtriva) 
                 84.0 
                 113.3 
                 110.1 
                 79.6 
                 48.0 
                 61.0 
                 62.8 
                 85.3 
                 86.9 
                 74.0 
                 77.1 
                 82.6 
                 119.4 
               
               
                 Lamivudine (Epivir) 
                 95.8 
                 102.2 
                 107.7 
                 86.4 
                 44.7 
                 54.1 
                 47.7 
                 71.1 
                 75.2 
                 83.2 
                 110.5 
                 71.3 
                 119.0 
               
               
                 Adefovir Dipivoxil  
                 81.7 
                 94.5 
                 95.5 
                 96.6 
                 35.1 
                 55.3 
                 46.1 
                 47.0 
                 47.3 
                 56.7 
                 91.3 
                 62.0 
                 60.4 
               
               
                 (Preveon, Hepsera) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Zalcitabine 
                 83.5 
                 147.3 
                 96.9 
                 89.2 
                 69.1 
                 86.4 
                 70.4 
                 79.0 
                 66.3 
                 52.7 
                 101.0 
                 91.0 
                 118.7 
               
               
                 Terbinafine (Lamisil,  
                 99.7 
                 103.8 
                 98.3 
                 65.2 
                 136.7 
                 103.5 
                 142.8 
                 109.1 
                 115.2 
                 103.9 
                 140.5 
                 94.0 
                 95.2 
               
               
                 Terbinex) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Prednisolone 
                 71.0 
                 76.6 
                 82.7 
                 78.7 
                 124.0 
                 82.5 
                 67.8 
                 86.2 
                 71.3 
                 45.5 
                 83.3 
                 92.5 
                 99.0 
               
               
                 (Hydroretrocortine) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Rifabutin (Mycobutin) 
                 84.0 
                 98.8 
                 147.6 
                 52.8 
                 115.2 
                 88.2 
                 62.4 
                 82.5 
                 53.1 
                 48.8 
                 72.6 
                 104.4 
                 100.2 
               
               
                 Nevirapine (Viramune) 
                 66.8 
                 76.6 
                 85.5 
                 58.9 
                 114.9 
                 89.7 
                 68.3 
                 102.7 
                 45.7 
                 38.5 
                 84.1 
                 85.7 
                 98.7 
               
               
                 Enoxacin (Penetrex) 
                 66.9 
                 78.9 
                 88.1 
                 68.5 
                 110.7 
                 92.3 
                 54.3 
                 90.4 
                 45.8 
                 44.5 
                 111.6 
                 83.8 
                 108.1 
               
               
                 Rifapentine (Priftin) 
                 77.7 
                 78.3 
                 101.6 
                 56.5 
                 63.7 
                 101.0 
                 58.6 
                 99.2 
                 47.4 
                 46.2 
                 99.1 
                 92.3 
                 99.1 
               
               
                 Pyrazinamide 
                 58.6 
                 55.4 
                 88.1 
                 54.3 
                 74.9 
                 79.1 
                 53.6 
                 88.3 
                 33.9 
                 40.9 
                 100.5 
                 56.9 
                 106.4 
               
               
                 Rifampin (Rifadin,  
                 61.6 
                 72.6 
                 98.5 
                 58.8 
                 111.0 
                 89.1 
                 61.1 
                 107.8 
                 45.2 
                 39.7 
                 69.9 
                 83.9 
                 105.1 
               
               
                 Rimactane) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cefditoren pivoxil 
                 69.1 
                 75.8 
                 96.9 
                 58.7 
                 86.5 
                 80.7 
                 70.5 
                 94.8 
                 45.7 
                 38.4 
                 83.9 
                 83.5 
                 110.5 
               
               
                 Sulfadiazine 
                 79.5 
                 52.5 
                 113.6 
                 43.7 
                 91.8 
                 69.2 
                 44.4 
                 80.4 
                 38.1 
                 37.2 
                 70.1 
                 93.6 
                 106.1 
               
               
                 Oxytetracycline  
                 51.2 
                 77.9 
                 88.4 
                 51.2 
                 61.9 
                 70.1 
                 56.7 
                 73.8 
                 42.3 
                 38.9 
                 70.8 
                 86.6 
                 97.9 
               
               
                 (Terramycin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ethionamide 
                 76.6 
                 73.5 
                 97.7 
                 44.8 
                 53.7 
                 78.3 
                 45.4 
                 53.2 
                 42.4 
                 36.4 
                 85.3 
                 86.5 
                 101.5 
               
               
                 Trifluridine (Viroptic) 
                 48.6 
                 53.8 
                 90.2 
                 51.8 
                 64.4 
                 71.0 
                 43.6 
                 51.3 
                 36.5 
                 36.3 
                 61.4 
                 72.1 
                 88.9 
               
               
                 Vidarabine (Vira-A) 
                 48.1 
                 75.1 
                 74.2 
                 47.7 
                 103.7 
                 78.8 
                 44.4 
                 68.6 
                 32.2 
                 36.5 
                 70.6 
                 72.9 
                 99.0 
               
               
                 Rifaximin (Xifaxan) 
                 59.5 
                 63.7 
                 101.9 
                 54.0 
                 93.2 
                 82.4 
                 52.7 
                 61.3 
                 35.1 
                 40.1 
                 67.1 
                 89.1 
                 100.3 
               
               
                 Acyclovir (Aciclovir) 
                 112.3 
                 96.0 
                 103.5 
                 87.2 
                 77.1 
                 101.2 
                 55.9 
                 107.1 
                 126.2 
                 75.8 
                 101.5 
                 66.3 
                 91.6 
               
               
                 Butoconazole nitrate 
                 101.9 
                 116.2 
                 114.0 
                 131.3 
                 78.7 
                 78.2 
                 48.7 
                 86.0 
                 89.6 
                 72.9 
                 57.1 
                 112.3 
                 41.3 
               
               
                 Albendazole Oxide 
                 92.9 
                 76.8 
                 103.7 
                 56.0 
                 34.0 
                 59.5 
                 60.8 
                 77.7 
                 154.8 
                 62.3 
                 60.5 
                 68.9 
                 102.6 
               
               
                 (Ricobendazole) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Chloroxine 
                 72.5 
                 65.4 
                 93.9 
                 71.7 
                 31.1 
                 77.1 
                 52.7 
                 62.7 
                 119.5 
                 68.7 
                 87.2 
                 85.5 
                 50.5 
               
               
                 Chenodeoxycholic acid 
                 64.2 
                 104.2 
                 94.8 
                 69.1 
                 68.9 
                 68.1 
                 51.8 
                 88.8 
                 96.3 
                 74.5 
                 71.4 
                 82.7 
                 118.2 
               
               
                 Bifonazole 
                 94.9 
                 111.8 
                 109.4 
                 67.2 
                 64.3 
                 55.9 
                 50.5 
                 82.1 
                 79.3 
                 73.3 
                 78.2 
                 81.1 
                 119.4 
               
               
                 Pefloxacin mesylate 
                 98.2 
                 114.1 
                 107.6 
                 61.3 
                 77.1 
                 54.7 
                 51.6 
                 89.4 
                 76.1 
                 62.9 
                 73.2 
                 80.3 
                 126.4 
               
               
                 Valaciclovir HCl 
                 95.6 
                 112.2 
                 110.4 
                 109.2 
                 109.7 
                 90.6 
                 91.6 
                 83.9 
                 126.3 
                 67.8 
                 68.3 
                 97.0 
                 103.4 
               
               
                 Ganciclovir 
                 94.8 
                 98.8 
                 108.8 
                 107.1 
                 105.8 
                 97.3 
                 87.0 
                 103.2 
                 104.2 
                 68.6 
                 71.8 
                 99.9 
                 98.7 
               
               
                 Protionamide  
                 84.9 
                 105.2 
                 117.7 
                 97.5 
                 85.9 
                 85.0 
                 77.6 
                 102.6 
                 66.2 
                 51.2 
                 45.2 
                 85.6 
                 97.6 
               
               
                 (Prothionamide) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Idoxuridine 
                 81.5 
                 69.3 
                 122.2 
                 101.3 
                 68.7 
                 82.8 
                 80.8 
                 88.0 
                 58.5 
                 47.3 
                 57.8 
                 72.7 
                 96.1 
               
               
                 Sparfloxacin 
                 82.6 
                 85.4 
                 97.6 
                 88.3 
                 79.9 
                 88.5 
                 57.5 
                 68.1 
                 86.5 
                 56.3 
                 50.1 
                 97.0 
                 99.3 
               
               
                 Metronidazole (Flagyl) 
                 56.4 
                 94.3 
                 104.6 
                 90.7 
                 90.5 
                 94.9 
                 57.7 
                 62.0 
                 36.5 
                 43.8 
                 40.9 
                 61.1 
                 90.8 
               
               
                 Tioconazole 
                 60.9 
                 77.6 
                 100.4 
                 58.5 
                 82.7 
                 72.9 
                 61.0 
                 68.1 
                 47.6 
                 48.0 
                 40.7 
                 83.2 
                 57.1 
               
               
                 Sulfamethoxazole 
                 44.3 
                 95.1 
                 115.4 
                 87.8 
                 67.7 
                 85.8 
                 60.7 
                 62.1 
                 43.9 
                 46.1 
                 44.9 
                 71.7 
                 99.4 
               
               
                 Sulfisoxazole 
                 65.5 
                 87.8 
                 107.8 
                 78.9 
                 88.7 
                 73.9 
                 48.4 
                 93.0 
                 39.4 
                 46.1 
                 36.1 
                 68.8 
                 95.2 
               
               
                 Crystal violet 
                 32.0 
                 41.9 
                 70.3 
                 38.9 
                 52.7 
                 68.5 
                 44.8 
                 44.1 
                 37.5 
                 46.0 
                 31.8 
                 62.3 
                 37.3 
               
               
                 Nystatin (Mycostatin) 
                 62.4 
                 79.7 
                 111.1 
                 59.2 
                 50.8 
                 65.4 
                 44.7 
                 42.1 
                 37.1 
                 46.4 
                 33.8 
                 70.9 
                 96.2 
               
               
                 Isoniazid (Tubizid) 
                 54.9 
                 60.1 
                 110.0 
                 77.9 
                 50.5 
                 64.7 
                 44.6 
                 42.2 
                 45.7 
                 44.7 
                 39.6 
                 71.0 
                 101.5 
               
               
                 Levofloxacin (Levaquin) 
                 39.3 
                 40.3 
                 88.4 
                 50.8 
                 51.6 
                 64.9 
                 44.5 
                 41.8 
                 36.7 
                 43.9 
                 29.6 
                 62.6 
                 93.0 
               
               
                 Miconazole nitrate 
                 31.5 
                 105.4 
                 103.9 
                 57.6 
                 51.1 
                 68.8 
                 45.0 
                 41.8 
                 37.3 
                 50.7 
                 30.4 
                 62.1 
                 41.4 
               
               
                 Sulfamethizole (Proklar) 
                 99.1 
                 87.8 
                 95.0 
                 105.3 
                 86.6 
                 99.2 
                 84.6 
                 114.5 
                 90.4 
                 100.0 
                 86.0 
                 86.4 
                 103.6 
               
               
                 Sulbactam 
                 84.5 
                 75.9 
                 91.9 
                 102.8 
                 80.5 
                 67.0 
                 77.8 
                 133.1 
                 81.1 
                 108.5 
                 105.9 
                 81.7 
                 104.1 
               
               
                 Sulphadimethoxine 
                 76.0 
                 98.5 
                 90.3 
                 68.8 
                 99.3 
                 83.1 
                 72.0 
                 131.7 
                 100.5 
                 94.3 
                 94.0 
                 70.8 
                 120.4 
               
               
                 Rimantadine (Flumadine) 
                 70.3 
                 98.6 
                 87.7 
                 71.1 
                 90.8 
                 96.9 
                 82.3 
                 126.4 
                 110.6 
                 97.1 
                 91.3 
                 95.7 
                 107.0 
               
               
                 Sarafloxacin HCl 
                 97.8 
                 80.0 
                 91.1 
                 81.0 
                 88.0 
                 58.9 
                 75.3 
                 121.9 
                 98.6 
                 107.4 
                 80.9 
                 106.5 
                 111.7 
               
               
                 Liranaftate 
                 84.5 
                 50.4 
                 79.8 
                 89.0 
                 73.6 
                 50.7 
                 76.7 
                 108.3 
                 67.1 
                 84.8 
                 92.7 
                 86.6 
                 92.0 
               
               
                 D-Cycloserine 
                 91.2 
                 62.5 
                 93.0 
                 81.7 
                 68.6 
                 50.8 
                 68.6 
                 114.1 
                 96.6 
                 112.8 
                 83.9 
                 102.8 
                 113.9 
               
               
                 Taurine 
                 77.6 
                 56.1 
                 93.1 
                 84.9 
                 64.1 
                 46.1 
                 61.6 
                 109.8 
                 84.0 
                 91.5 
                 61.1 
                 98.5 
                 115.7 
               
               
                 Diclazuril 
                 84.5 
                 108.9 
                 99.3 
                 76.1 
                 76.3 
                 104.5 
                 97.9 
                 103.1 
                 42.7 
                 40.4 
                 95.5 
                 78.4 
                 70.2 
               
               
                 Rebamipide 
                 81.1 
                 88.1 
                 95.3 
                 77.4 
                 89.6 
                 80.4 
                 97.4 
                 105.4 
                 28.0 
                 39.1 
                 82.2 
                 84.9 
                 100.0 
               
               
                 Clindamycin phosphate 
                 81.3 
                 108.1 
                 90.2 
                 61.4 
                 91.6 
                 87.0 
                 85.6 
                 79.6 
                 31.0 
                 38.3 
                 40.0 
                 44.4 
                 109.8 
               
               
                 Oxytetracycline dihydrate 
                 72.5 
                 110.0 
                 93.4 
                 65.6 
                 71.7 
                 73.8 
                 81.4 
                 53.4 
                 22.1 
                 34.2 
                 42.1 
                 47.0 
                 99.3 
               
               
                 Orphenadrine citrate  
                 89.2 
                 117.1 
                 97.8 
                 67.9 
                 82.9 
                 99.6 
                 101.7 
                 53.4 
                 21.8 
                 35.9 
                 41.6 
                 45.6 
                 92.9 
               
               
                 (Norflex) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Terazosin HCl (Hytrin) 
                 77.9 
                 97.2 
                 93.4 
                 60.7 
                 56.8 
                 74.9 
                 82.1 
                 71.6 
                 21.3 
                 33.4 
                 40.5 
                 45.7 
                 110.8 
               
               
                 Lafutidine 
                 116.3 
                 74.3 
                 101.9 
                 46.9 
                 45.5 
                 80.1 
                 89.6 
                 51.9 
                 21.3 
                 33.6 
                 40.7 
                 48.0 
                 95.3 
               
               
                 Dextrose (D-glucose) 
                 77.0 
                 121.4 
                 100.7 
                 74.4 
                 58.4 
                 71.1 
                 83.9 
                 78.8 
                 80.9 
                 93.2 
                 95.0 
                 85.3 
                 104.3 
               
               
                 BIBR-1048 (Dabigatran) 
                 50.9 
                 78.9 
                 74.0 
                 71.9 
                 62.4 
                 62.7 
                 58.0 
                 83.8 
                 73.8 
                 85.8 
                 86.9 
                 90.9 
                 87.9 
               
               
                 Rosuvastatin calcium  
                 55.6 
                 139.9 
                 73.7 
                 74.6 
                 55.9 
                 80.8 
                 83.8 
                 56.0 
                 97.0 
                 88.9 
                 94.3 
                 101.0 
                 81.7 
               
               
                 (Crestor) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Nalidixic acid (NegGram) 
                 87.9 
                 78.9 
                 96.8 
                 95.8 
                 57.3 
                 72.0 
                 54.9 
                 46.3 
                 83.8 
                 86.0 
                 74.6 
                 91.5 
                 113.3 
               
               
                 Ammonium Glycyrrhizinate  
                 75.5 
                 74.3 
                 94.9 
                 74.1 
                 50.5 
                 75.8 
                 49.2 
                 53.7 
                 58.0 
                 81.0 
                 64.0 
                 81.3 
                 127.9 
               
               
                 (AMGZ) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amfebutamone (Bupropion) 
                 88.2 
                 79.1 
                 85.1 
                 53.4 
                 30.0 
                 74.3 
                 52.1 
                 44.9 
                 59.2 
                 64.7 
                 62.8 
                 51.4 
                 117.9 
               
               
                 Clonidine hydrochloride 
                 62.5 
                 25.6 
                 83.7 
                 72.0 
                 36.4 
                 64.1 
                 48.8 
                 28.5 
                 37.3 
                 68.8 
                 40.7 
                 72.1 
                 127.5 
               
               
                 (Catapres) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Fenbendazole (Panacur) 
                 40.6 
                 34.1 
                 76.1 
                 38.6 
                 29.9 
                 60.2 
                 40.3 
                 27.2 
                 40.9 
                 55.8 
                 42.0 
                 52.9 
                 66.6 
               
               
                 Fluocinolone acetonide 
                 45.8 
                 26.3 
                 74.5 
                 46.0 
                 30.0 
                 58.4 
                 34.9 
                 38.3 
                 52.5 
                 54.2 
                 40.7 
                 52.3 
                 116.3 
               
               
                 (Flucort-N) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Loperamide hydrochloride 
                 58.8 
                 65.5 
                 103.2 
                 73.0 
                 57.3 
                 66.7 
                 64.3 
                 42.7 
                 104.2 
                 78.9 
                 64.7 
                 64.8 
                 100.8 
               
               
                 Mycophenolic  
                 57.4 
                 47.8 
                 72.9 
                 90.7 
                 57.8 
                 83.1 
                 61.7 
                 40.3 
                 80.6 
                 120.5 
                 74.3 
                 70.1 
                 65.6 
               
               
                 (Mycophenolate) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Olanzapine (Zyprexa) 
                 91.9 
                 108.8 
                 93.3 
                 106.4 
                 84.2 
                 109.0 
                 80.1 
                 58.7 
                 88.0 
                 124.9 
                 92.2 
                 88.5 
                 118.2 
               
               
                 Racecadotril (Acetorphan) 
                 66.2 
                 109.8 
                 88.8 
                 65.6 
                 84.0 
                 82.9 
                 97.4 
                 65.6 
                 95.8 
                 107.9 
                 106.7 
                 74.5 
                 121.5 
               
               
                 Rosiglitazone maleate 
                 70.3 
                 96.1 
                 95.1 
                 83.3 
                 113.1 
                 87.7 
                 73.7 
                 85.2 
                 79.1 
                 114.3 
                 121.3 
                 93.5 
                 109.2 
               
               
                 Salbutamol sulfate  
                 98.0 
                 100.8 
                 87.8 
                 99.9 
                 91.8 
                 84.3 
                 71.2 
                 62.3 
                 94.6 
                 139.6 
                 107.9 
                 97.1 
                 104.1 
               
               
                 (Albuterol) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Sulfadoxine (Sulphadoxine) 
                 65.5 
                 100.8 
                 90.5 
                 78.2 
                 91.1 
                 62.2 
                 87.4 
                 64.3 
                 96.6 
                 131.7 
                 119.1 
                 92.9 
                 110.7 
               
               
                 Tenoxicam (Mobilflex) 
                 80.2 
                 104.2 
                 89.1 
                 89.7 
                 97.7 
                 69.9 
                 94.9 
                 67.3 
                 98.6 
                 126.4 
                 120.4 
                 94.6 
                 113.9 
               
               
                 Vardenafil (Vivanza) 
                 73.2 
                 90.3 
                 81.8 
                 61.7 
                 86.5 
                 67.2 
                 68.2 
                 57.8 
                 96.5 
                 117.0 
                 110.8 
                 105.9 
                 126.9 
               
               
                 Dopamine hydrochloride 
                 83.0 
                 90.6 
                 100.8 
                 85.1 
                 74.3 
                 76.0 
                 85.0 
                 57.7 
                 101.8 
                 148.3 
                 115.2 
                 84.3 
                 91.5 
               
               
                 (Inotropin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ritodrine hydrochloride 
                 87.4 
                 114.4 
                 92.8 
                 132.9 
                 80.1 
                 96.4 
                 97.2 
                 64.4 
                 95.5 
                 86.5 
                 113.4 
                 103.6 
                 86.0 
               
               
                 (Yutopar) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Isoconazole nitrate  
                 95.0 
                 129.5 
                 99.4 
                 165.3 
                 74.8 
                 102.2 
                 125.7 
                 88.2 
                 91.7 
                 95.1 
                 82.5 
                 101.7 
                 49.2 
               
               
                 (Travogen) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Secnidazole (Flagentyl) 
                 117.0 
                 96.6 
                 99.0 
                 124.3 
                 78.0 
                 46.8 
                 77.2 
                 52.1 
                 69.2 
                 81.0 
                 81.6 
                 85.4 
                 97.2 
               
               
                 Lomefloxacin HCl  
                 87.7 
                 113.4 
                 90.5 
                 135.0 
                 77.5 
                 56.6 
                 92.7 
                 61.2 
                 70.7 
                 83.5 
                 63.3 
                 88.9 
                 96.5 
               
               
                 (Maxaquin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Riboflavin (Vitamin B2) 
                 89.7 
                 92.5 
                 100.8 
                 128.5 
                 74.9 
                 51.1 
                 87.3 
                 79.7 
                 67.6 
                 74.6 
                 79.4 
                 83.3 
                 90.0 
               
               
                 Clomipramine HCl  
                 88.9 
                 119.1 
                 115.6 
                 167.6 
                 60.2 
                 47.5 
                 70.5 
                 46.2 
                 69.1 
                 75.7 
                 75.8 
                 87.1 
                 82.7 
               
               
                 (Anafranil) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ceftiofur hydrochloride 
                 92.8 
                 114.2 
                 91.9 
                 92.2 
                 69.4 
                 44.0 
                 85.5 
                 50.6 
                 61.6 
                 159.3 
                 73.1 
                 85.0 
                 92.2 
               
               
                 Tiotropium Bromide hydrate 
                 86.3 
                 110.6 
                 90.9 
                 123.5 
                 73.1 
                 40.9 
                 86.1 
                 54.7 
                 62.0 
                 80.0 
                 83.8 
                 88.7 
                 87.8 
               
               
                 Sulbactam sodium (Unasyn) 
                 101.2 
                 109.4 
                 87.6 
                 87.4 
                 73.5 
                 40.6 
                 74.7 
                 48.8 
                 65.9 
                 73.5 
                 74.5 
                 80.6 
                 97.2 
               
               
                 Terbinafine HCl (Lamisil) 
                 92.5 
                 76.9 
                 91.1 
                 75.4 
                 90.6 
                 40.6 
                 81.8 
                 50.6 
                 52.3 
                 67.7 
                 70.8 
                 71.4 
                 86.5 
               
               
                 Amoxicillin sodium (Amox) 
                 78.5 
                 106.2 
                 80.8 
                 81.0 
                 51.2 
                 43.3 
                 63.2 
                 45.4 
                 60.6 
                 60.4 
                 74.8 
                 69.1 
                 95.5 
               
               
                 Isoprenaline hydrochloride 
                 90.0 
                 110.5 
                 81.4 
                 91.1 
                 72.0 
                 39.9 
                 79.6 
                 81.6 
                 56.1 
                 73.2 
                 73.6 
                 80.6 
                 96.8 
               
               
                 Medroxyprogesterone  
                 81.0 
                 112.5 
                 78.6 
                 70.4 
                 72.3 
                 38.6 
                 66.9 
                 79.4 
                 60.5 
                 69.3 
                 82.0 
                 65.9 
                 51.7 
               
               
                 acetate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Streptomycin sulfate 
                 77.5 
                 114.5 
                 84.5 
                 88.9 
                 65.5 
                 40.6 
                 68.7 
                 23.3 
                 57.3 
                 72.0 
                 59.1 
                 46.6 
                 93.3 
               
               
                 Tetracycline HCl 
                 74.1 
                 114.8 
                 74.1 
                 96.1 
                 88.2 
                 41.1 
                 55.9 
                 34.1 
                 72.8 
                 75.9 
                 42.9 
                 71.8 
                 93.7 
               
               
                 Xylometazoline HCl 
                 65.1 
                 70.5 
                 83.0 
                 106.6 
                 52.2 
                 33.4 
                 65.8 
                 42.6 
                 74.7 
                 94.4 
                 54.8 
                 47.1 
                 84.9 
               
               
                 Phenacetin 
                 54.1 
                 65.6 
                 72.5 
                 57.2 
                 40.4 
                 39.1 
                 75.1 
                 23.3 
                 34.4 
                 62.7 
                 40.4 
                 48.5 
                 95.3 
               
               
                 Trazodone HCl (Desyrel) 
                 54.4 
                 92.1 
                 85.1 
                 86.7 
                 43.4 
                 39.7 
                 78.1 
                 52.1 
                 34.1 
                 69.2 
                 49.6 
                 56.4 
                 90.8 
               
               
                 Brompheniramine 
                 101.7 
                 101.9 
                 95.7 
                 111.0 
                 121.1 
                 83.0 
                 85.8 
                 97.9 
                 109.3 
                 75.8 
                 96.9 
                 98.9 
                 121.5 
               
               
                 Clindamycin palmitate HCl 
                 92.3 
                 85.7 
                 108.4 
                 66.7 
                 43.0 
                 67.7 
                 84.1 
                 92.4 
                 128.3 
                 87.6 
                 100.7 
                 93.5 
                 93.3 
               
               
                 Acemetacin (Emflex) 
                 68.4 
                 89.3 
                 109.9 
                 70.9 
                 69.0 
                 78.2 
                 102.9 
                 99.4 
                 88.1 
                 87.3 
                 90.5 
                 94.7 
                 120.0 
               
               
                 Dabrafenib (GSK2118436) 
                 42.1 
                 78.0 
                 91.3 
                 78.5 
                 90.1 
                 73.6 
                 98.7 
                 90.5 
                 133.6 
                 94.1 
                 100.1 
                 70.5 
                 72.9 
               
               
                 Clindamycin 
                 55.6 
                 86.7 
                 96.5 
                 75.5 
                 86.2 
                 63.3 
                 58.8 
                 67.2 
                 127.7 
                 86.0 
                 111.7 
                 92.4 
                 144.7 
               
               
                 Paroxetine HCl 
                 31.9 
                 37.7 
                 65.8 
                 42.1 
                 21.5 
                 44.1 
                 49.2 
                 56.4 
                 80.1 
                 56.4 
                 70.6 
                 53.8 
                 79.1 
               
               
                 Zanamivir (Relenza) 
                 51.5 
                 84.7 
                 109.8 
                 71.8 
                 75.1 
                 62.7 
                 85.8 
                 88.5 
                 93.0 
                 69.6 
                 106.2 
                 77.3 
                 146.0 
               
               
                 Niflumic acid 
                 50.0 
                 48.9 
                 87.4 
                 51.9 
                 40.5 
                 50.8 
                 68.7 
                 66.8 
                 99.2 
                 86.9 
                 111.3 
                 82.0 
                 131.6 
               
               
                 Ciclopirox ethanolamine 
                 33.0 
                 42.6 
                 109.5 
                 74.4 
                 28.8 
                 47.9 
                 53.0 
                 45.5 
                 60.5 
                 68.2 
                 87.1 
                 71.5 
                 57.7 
               
               
                 Enrofloxacin 
                 65.2 
                 75.8 
                 77.2 
                 67.0 
                 94.5 
                 44.5 
                 37.4 
                 77.9 
                 67.5 
                 66.6 
                 48.6 
                 84.8 
                 86.6 
               
               
                 Medetomidine HCl 
                 59.7 
                 70.4 
                 91.9 
                 78.4 
                 107.8 
                 49.8 
                 37.4 
                 104.5 
                 73.7 
                 72.3 
                 65.6 
                 79.4 
                 84.5 
               
               
                 Diclofenac Potassium 
                 51.5 
                 88.8 
                 107.3 
                 76.1 
                 91.4 
                 43.9 
                 40.5 
                 122.4 
                 81.7 
                 76.3 
                 63.3 
                 85.0 
                 96.3 
               
               
                 Amikacin sulfate 
                 32.5 
                 61.9 
                 83.8 
                 73.3 
                 53.7 
                 39.9 
                 40.7 
                 55.3 
                 52.3 
                 62.8 
                 51.6 
                 60.5 
                 131.4 
               
               
                 Caspofungin acetate 
                 70.5 
                 86.3 
                 95.3 
                 67.7 
                 94.2 
                 37.1 
                 36.4 
                 123.7 
                 78.4 
                 74.7 
                 59.4 
                 83.9 
                 124.4 
               
               
                 Ulipristal 
                 48.2 
                 88.2 
                 69.0 
                 72.4 
                 55.4 
                 40.3 
                 36.1 
                 55.8 
                 59.9 
                 65.4 
                 49.3 
                 67.8 
                 93.8 
               
               
                 Indacaterol Maleate 
                 45.7 
                 65.2 
                 81.2 
                 71.8 
                 54.1 
                 36.0 
                 30.3 
                 56.0 
                 65.1 
                 68.7 
                 55.5 
                 61.4 
                 87.2 
               
               
                 Sulfathiazole 
                 30.8 
                 50.9 
                 65.7 
                 47.7 
                 54.6 
                 38.8 
                 30.8 
                 54.5 
                 47.2 
                 60.1 
                 94.9 
                 78.1 
                 96.7 
               
               
                 Amikacin hydrate 
                 87.7 
                 77.0 
                 88.4 
                 96.3 
                 85.8 
                 87.7 
                 104.5 
                 138.3 
                 111.0 
                 81.4 
                 101.8 
                 99.0 
                 108.2 
               
               
                 Trimethoprim 
                 83.6 
                 92.0 
                 102.5 
                 89.0 
                 97.7 
                 108.1 
                 73.6 
                 92.4 
                 125.3 
                 104.5 
                 150.8 
                 98.7 
                 96.8 
               
               
                 Biotin (Vitamin B7) 
                 71.3 
                 76.1 
                 100.6 
                 90.7 
                 103.5 
                 94.2 
                 85.1 
                 93.5 
                 86.4 
                 89.1 
                 131.8 
                 99.2 
                 85.2 
               
               
                 Sulfamerazine 
                 80.4 
                 76.8 
                 101.0 
                 92.3 
                 87.9 
                 108.2 
                 87.4 
                 90.0 
                 103.4 
                 79.8 
                 78.4 
                 99.6 
                 105.4 
               
               
                 Sodium salicylate 
                 74.9 
                 73.5 
                 84.3 
                 94.4 
                 82.1 
                 90.1 
                 77.9 
                 136.8 
                 107.4 
                 89.0 
                 87.9 
                 102.0 
                 94.7 
               
               
                 Methylthiouracil 
                 72.1 
                 65.8 
                 106.2 
                 88.3 
                 84.8 
                 90.2 
                 79.9 
                 83.6 
                 163.5 
                 101.3 
                 150.8 
                 98.9 
                 106.4 
               
               
                 Darifenacin HBr 
                 60.5 
                 65.3 
                 81.6 
                 87.7 
                 80.4 
                 126.3 
                 82.4 
                 99.8 
                 100.5 
                 59.7 
                 86.1 
                 93.5 
                 78.2 
               
               
                 Naftifine HCl 
                 63.3 
                 57.5 
                 91.2 
                 80.6 
                 104.0 
                 72.3 
                 58.5 
                 79.6 
                 127.0 
                 84.5 
                 108.6 
                 86.3 
                 93.2 
               
               
                 Sertaconazole nitrate 
                 52.0 
                 53.9 
                 77.4 
                 58.9 
                 97.1 
                 96.3 
                 69.5 
                 89.4 
                 75.4 
                 76.4 
                 77.2 
                 94.9 
                 73.4 
               
               
                 Benztropine mesylate 
                 67.5 
                 62.0 
                 86.0 
                 95.3 
                 83.0 
                 91.7 
                 89.4 
                 101.3 
                 68.2 
                 63.3 
                 75.3 
                 81.4 
                 81.1 
               
               
                 Abacavir sulfate 
                 57.2 
                 46.2 
                 82.6 
                 84.2 
                 97.1 
                 67.0 
                 94.6 
                 147.6 
                 87.0 
                 79.6 
                 76.0 
                 100.5 
                 107.5 
               
               
                 Ampicillin sodium 
                 68.9 
                 45.7 
                 76.1 
                 75.2 
                 105.0 
                 53.5 
                 77.9 
                 72.0 
                 102.6 
                 99.1 
                 98.1 
                 88.9 
                 103.8 
               
               
                 Antipyrine 
                 77.9 
                 50.0 
                 104.9 
                 76.8 
                 109.0 
                 57.3 
                 109.0 
                 90.1 
                 76.4 
                 61.3 
                 76.8 
                 97.1 
                 101.6 
               
               
                 Carbenicillin disodium 
                 70.2 
                 45.4 
                 88.9 
                 77.8 
                 62.9 
                 76.2 
                 84.3 
                 84.3 
                 53.5 
                 59.0 
                 84.4 
                 86.2 
                 113.8 
               
               
                 Amitriptyline HCl 
                 84.8 
                 44.0 
                 105.5 
                 90.6 
                 61.5 
                 64.4 
                 102.4 
                 132.9 
                 69.3 
                 64.8 
                 61.9 
                 96.5 
                 81.4 
               
               
                 Azatadine dimaleate 
                 40.7 
                 30.2 
                 84.5 
                 72.2 
                 67.1 
                 48.5 
                 83.4 
                 78.5 
                 123.1 
                 79.7 
                 104.3 
                 95.7 
                 112.6 
               
               
                 Triflusal 
                 95.9 
                 90.9 
                 102.7 
                 104.8 
                 93.3 
                 81.3 
                 133.8 
                 86.5 
                 112.5 
                 97.8 
                 87.5 
                 102.6 
                 93.3 
               
               
                 Clinafloxacin (PD127391) 
                 59.3 
                 72.9 
                 73.8 
                 97.0 
                 74.2 
                 72.4 
                 91.3 
                 83.3 
                 67.5 
                 78.6 
                 36.7 
                 92.7 
                 71.2 
               
               
                 Pentamidine 
                 38.2 
                 47.3 
                 76.4 
                 55.9 
                 50.6 
                 65.8 
                 86.3 
                 59.3 
                 51.8 
                 68.5 
                 33.2 
                 74.4 
                 57.8 
               
               
                 Pemirolast (BMY 26517) 
                 70.8 
                 54.7 
                 82.1 
                 88.4 
                 69.4 
                 81.8 
                 100.7 
                 93.7 
                 82.9 
                 83.2 
                 53.8 
                 107.4 
                 101.1 
               
               
                 potassium 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Homatropine Bromide 
                 41.2 
                 61.6 
                 70.7 
                 79.0 
                 25.2 
                 67.2 
                 76.8 
                 52.2 
                 63.8 
                 70.2 
                 38.4 
                 86.5 
                 96.5 
               
               
                 Colistin Sulfate 
                 36.1 
                 74.6 
                 77.7 
                 84.3 
                 26.1 
                 62.2 
                 92.4 
                 36.2 
                 97.6 
                 66.7 
                 41.4 
                 92.0 
                 108.9 
               
               
                 toltrazuril 
                 27.7 
                 33.4 
                 62.2 
                 70.1 
                 26.3 
                 70.9 
                 74.6 
                 34.8 
                 61.2 
                 67.4 
                 30.3 
                 61.9 
                 73.1 
               
               
                 Carbimazole 
                 65.1 
                 123.5 
                 97.2 
                 90.3 
                 113.5 
                 80.9 
                 131.3 
                 116.7 
                 73.9 
                 102.1 
                 95.6 
                 75.0 
                 80.1 
               
               
                 Netilmicin Sulfate 
                 70.1 
                 102.1 
                 99.4 
                 108.6 
                 116.0 
                 87.6 
                 110.1 
                 123.4 
                 100.0 
                 106.3 
                 92.1 
                 92.9 
                 87.8 
               
               
                 Spironolactone 
                 61.0 
                 99.5 
                 90.5 
                 117.6 
                 96.6 
                 79.8 
                 117.0 
                 90.1 
                 67.5 
                 87.7 
                 88.5 
                 67.2 
                 57.2 
               
               
                 Ropivacaine HCl 
                 71.2 
                 109.3 
                 98.0 
                 126.2 
                 64.3 
                 92.4 
                 131.8 
                 101.0 
                 117.9 
                 99.2 
                 109.8 
                 89.7 
                 81.3 
               
               
                 Erythromycin  
                 75.0 
                 123.8 
                 97.1 
                 147.8 
                 111.4 
                 83.8 
                 128.9 
                 125.1 
                 90.0 
                 88.2 
                 111.9 
                 80.0 
                 83.6 
               
               
                 Ethylsuccinate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Escitalopram oxalate 
                 68.0 
                 98.4 
                 94.0 
                 95.0 
                 62.3 
                 80.4 
                 115.5 
                 80.6 
                 122.0 
                 97.4 
                 79.5 
                 91.6 
                 92.7 
               
               
                 tinidazole 
                 60.6 
                 71.6 
                 95.5 
                 97.8 
                 104.4 
                 91.1 
                 100.5 
                 111.7 
                 79.5 
                 88.0 
                 85.6 
                 78.5 
                 89.0 
               
               
                 Pyrithione zinc 
                 27.1 
                 39.6 
                 70.4 
                 47.4 
                 35.4 
                 60.6 
                 57.4 
                 28.7 
                 29.7 
                 51.8 
                 24.3 
                 45.5 
                 34.5 
               
               
                 Mequinol 
                 63.8 
                 86.0 
                 95.6 
                 87.1 
                 57.2 
                 67.5 
                 102.8 
                 97.0 
                 118.0 
                 74.4 
                 68.0 
                 85.2 
                 112.2 
               
               
                 Spiramycin 
                 53.3 
                 74.5 
                 80.3 
                 74.4 
                 57.8 
                 68.2 
                 96.7 
                 55.0 
                 81.8 
                 85.4 
                 65.9 
                 73.5 
                 90.1 
               
               
                 Bismuth Subcitrate  
                 81.6 
                 76.9 
                 93.0 
                 98.7 
                 79.6 
                 69.9 
                 126.0 
                 86.0 
                 113.5 
                 82.6 
                 78.1 
                 76.1 
                 101.0 
               
               
                 Potassium 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Clofazimine 
                 37.3 
                 41.4 
                 82.2 
                 59.3 
                 64.2 
                 74.4 
                 53.1 
                 51.7 
                 49.5 
                 51.2 
                 53.2 
                 68.3 
                 85.0 
               
               
                 Dicloxacillin Sodium 
                 79.0 
                 56.0 
                 102.0 
                 60.1 
                 147.3 
                 68.4 
                 66.4 
                 84.3 
                 61.8 
                 45.3 
                 71.1 
                 92.4 
                 72.7 
               
               
                 Sulconazole Nitrate 
                 44.9 
                 50.4 
                 88.2 
                 62.1 
                 83.1 
                 63.4 
                 53.2 
                 55.0 
                 50.7 
                 44.4 
                 65.7 
                 73.6 
                 64.1 
               
               
                 Tilmicosin 
                 54.7 
                 50.6 
                 92.1 
                 67.0 
                 102.0 
                 72.7 
                 52.1 
                 56.5 
                 53.5 
                 39.1 
                 81.5 
                 83.8 
                 75.0 
               
               
                 Bacitracin 
                 54.7 
                 53.2 
                 86.4 
                 68.4 
                 61.4 
                 65.4 
                 46.9 
                 68.3 
                 51.4 
                 41.4 
                 70.0 
                 69.9 
                 85.9 
               
               
                 Azithromycin Dihydrate 
                 50.8 
                 40.9 
                 81.1 
                 55.6 
                 72.7 
                 61.3 
                 51.2 
                 39.4 
                 41.4 
                 36.4 
                 43.0 
                 65.3 
                 101.1 
               
               
                 Ampicillin Trihydrate 
                 53.7 
                 52.2 
                 92.4 
                 59.3 
                 95.3 
                 63.6 
                 56.3 
                 61.3 
                 41.9 
                 36.5 
                 65.3 
                 78.4 
                 92.7 
               
               
                 Orbifloxacin 
                 55.6 
                 42.1 
                 84.2 
                 66.8 
                 84.5 
                 63.7 
                 44.1 
                 44.3 
                 44.2 
                 33.3 
                 51.1 
                 75.4 
                 92.3 
               
               
                 Chlortetracycline HCl 
                 49.2 
                 49.9 
                 75.0 
                 83.9 
                 69.7 
                 59.9 
                 43.0 
                 50.4 
                 45.8 
                 32.2 
                 38.2 
                 61.4 
                 83.9 
               
               
                 Benzylpenicillin sodium 
                 51.7 
                 56.4 
                 86.4 
                 57.1 
                 54.8 
                 57.1 
                 43.1 
                 39.6 
                 36.4 
                 31.3 
                 36.1 
                 62.8 
                 86.7 
               
               
                 Chlorpropamide 
                 62.1 
                 35.9 
                 92.5 
                 59.9 
                 51.2 
                 55.8 
                 42.7 
                 59.1 
                 36.9 
                 32.5 
                 44.4 
                 59.3 
                 96.7 
               
               
                 Cetylpyridinium Chloride 
                 35.6 
                 33.6 
                 60.9 
                 37.1 
                 33.4 
                 48.7 
                 47.4 
                 37.2 
                 29.2 
                 40.9 
                 37.1 
                 50.7 
                 30.8 
               
               
                 Sulfaguanidine 
                 144.7 
                 91.1 
                 96.1 
                 113.2 
                 84.0 
                 95.6 
                 83.5 
                 107.3 
                 82.2 
                 92.6 
                 85.9 
                 78.9 
                 99.1 
               
               
                 Climbazole 
                 70.6 
                 54.7 
                 94.4 
                 94.0 
                 93.3 
                 84.2 
                 97.7 
                 102.3 
                 72.7 
                 100.8 
                 99.6 
                 101.0 
                 111.3 
               
               
                 Mezlocillin Sodium 
                 106.9 
                 75.3 
                 95.1 
                 111.2 
                 72.2 
                 81.0 
                 92.9 
                 91.9 
                 78.0 
                 106.6 
                 97.8 
                 115.5 
                 91.4 
               
               
                 Nifuroxazide 
                 51.6 
                 42.0 
                 73.0 
                 66.6 
                 36.7 
                 57.6 
                 51.0 
                 56.2 
                 33.2 
                 80.1 
                 92.0 
                 58.3 
                 38.8 
               
               
                 Paromomycin Sulfate 
                 91.4 
                 84.5 
                 101.1 
                 96.2 
                 80.2 
                 99.0 
                 92.1 
                 106.2 
                 78.2 
                 112.3 
                 146.4 
                 67.1 
                 87.1 
               
               
                 Penciclovir 
                 64.2 
                 62.2 
                 95.7 
                 81.7 
                 71.0 
                 71.5 
                 98.5 
                 79.1 
                 74.7 
                 110.3 
                 106.2 
                 98.5 
                 113.7 
               
               
                 Domiphen Bromide 
                 36.3 
                 34.0 
                 62.1 
                 38.0 
                 32.5 
                 46.5 
                 44.4 
                 37.3 
                 28.7 
                 31.3 
                 38.9 
                 48.7 
                 30.0 
               
               
                 Salicylanilide 
                 92.8 
                 70.4 
                 97.2 
                 117.7 
                 77.8 
                 80.5 
                 83.5 
                 108.2 
                 62.1 
                 106.4 
                 89.7 
                 86.2 
                 71.1 
               
               
                 Betamipron 
                 85.8 
                 56.7 
                 90.9 
                 75.9 
                 75.2 
                 72.8 
                 88.2 
                 85.4 
                 72.3 
                 117.6 
                 92.6 
                 93.5 
                 96.2 
               
               
                 Chlorquinaldol 
                 43.0 
                 34.5 
                 82.3 
                 42.6 
                 35.7 
                 59.6 
                 75.4 
                 70.5 
                 54.5 
                 47.8 
                 68.4 
                 62.8 
                 64.8 
               
               
                 Ethacridine lactate  
                 40.1 
                 38.9 
                 65.5 
                 39.9 
                 38.2 
                 52.5 
                 49.7 
                 46.8 
                 75.1 
                 68.7 
                 64.6 
                 50.1 
                 44.1 
               
               
                 monohydrate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Aminothiazole 
                 78.4 
                 59.9 
                 90.4 
                 65.7 
                 62.3 
                 68.7 
                 101.2 
                 86.0 
                 56.1 
                 108.4 
                 93.8 
                 86.4 
                 120.8 
               
               
                 Florfenicol 
                 88.4 
                 99.0 
                 161.3 
                 95.1 
                 100.6 
                 87.0 
                 117.4 
                 86.9 
                 67.8 
                 122.6 
                 101.7 
                 92.9 
                 109.3 
               
               
                 Furaltadone HCl 
                 66.0 
                 66.0 
                 83.2 
                 64.0 
                 68.2 
                 83.1 
                 72.6 
                 81.3 
                 67.9 
                 102.8 
                 99.2 
                 62.2 
                 64.6 
               
               
                 Dirithromycin 
                 83.7 
                 85.3 
                 90.6 
                 91.9 
                 63.2 
                 65.5 
                 106.3 
                 77.2 
                 64.8 
                 62.6 
                 77.1 
                 83.7 
                 90.2 
               
               
                 Valnemulin HCl 
                 57.1 
                 95.8 
                 126.1 
                 116.6 
                 75.5 
                 78.8 
                 91.4 
                 66.9 
                 62.2 
                 66.7 
                 83.4 
                 73.6 
                 93.3 
               
               
                 Piperacillin Sodium 
                 67.9 
                 91.8 
                 96.3 
                 91.8 
                 98.3 
                 71.6 
                 87.1 
                 87.1 
                 37.1 
                 52.3 
                 79.3 
                 97.4 
                 108.3 
               
               
                 Minocycline HCl 
                 81.6 
                 105.2 
                 103.3 
                 101.1 
                 87.6 
                 74.0 
                 95.0 
                 60.4 
                 42.5 
                 49.9 
                 53.8 
                 87.3 
                 68.1 
               
               
                 Fidaxomicin 
                 70.3 
                 101.8 
                 99.6 
                 82.2 
                 94.9 
                 61.2 
                 94.2 
                 82.4 
                 40.6 
                 46.6 
                 59.4 
                 89.6 
                 99.2 
               
               
                 Primaquine Diphosphate 
                 44.6 
                 69.5 
                 81.4 
                 55.0 
                 43.9 
                 56.4 
                 64.3 
                 55.5 
                 31.4 
                 36.7 
                 60.3 
                 72.6 
                 34.1 
               
               
                 Cetrimonium Bromide 
                 36.1 
                 62.3 
                 62.8 
                 42.6 
                 42.4 
                 54.6 
                 61.5 
                 34.8 
                 25.0 
                 36.4 
                 38.7 
                 55.4 
                 27.9 
               
               
                 Carbadox 
                 52.4 
                 72.8 
                 88.7 
                 60.0 
                 51.9 
                 56.9 
                 104.1 
                 67.9 
                 24.8 
                 34.6 
                 52.5 
                 54.4 
                 87.0 
               
               
                 Ceftazidime Pentahydrate 
                 87.7 
                 89.5 
                 93.6 
                 70.0 
                 53.5 
                 58.5 
                 94.6 
                 78.7 
                 26.7 
                 35.5 
                 38.5 
                 72.5 
                 89.3 
               
               
                 Clinafoxacin HCl 
                 46.4 
                 96.1 
                 74.8 
                 56.5 
                 48.1 
                 59.8 
                 66.9 
                 80.5 
                 33.5 
                 34.3 
                 38.4 
                 54.1 
                 85.9 
               
               
                 Colistimethate Sodium 
                 48.2 
                 61.9 
                 64.5 
                 42.9 
                 43.0 
                 55.7 
                 62.7 
                 33.7 
                 25.4 
                 37.1 
                 39.6 
                 57.5 
                 94.0 
               
               
                 Meclocycline Sulfosalicylate 
                 92.8 
                 99.5 
                 94.4 
                 90.6 
                 88.1 
                 92.2 
                 140.8 
                 44.2 
                 62.1 
                 95.0 
                 77.6 
                 101.1 
                 81.3 
               
               
                 Moxalactam Disodium 
                 80.8 
                 73.9 
                 79.1 
                 61.3 
                 76.9 
                 66.9 
                 110.5 
                 55.9 
                 76.6 
                 80.7 
                 95.0 
                 94.0 
                 100.8 
               
               
                 Piromidic Acid 
                 86.7 
                 89.8 
                 73.8 
                 95.5 
                 85.9 
                 67.2 
                 100.1 
                 90.5 
                 80.5 
                 99.5 
                 107.1 
                 95.2 
                 95.2 
               
               
                 Rolitetracycline 
                 82.5 
                 67.7 
                 71.2 
                 53.9 
                 61.1 
                 113.1 
                 95.7 
                 54.3 
                 111.6 
                 88.8 
                 105.0 
                 86.1 
                 101.8 
               
               
                 Thiostrepton 
                 27.6 
                 35.6 
                 49.2 
                 37.8 
                 25.7 
                 45.4 
                 56.7 
                 20.1 
                 62.2 
                 65.0 
                 55.7 
                 52.9 
                 37.8 
               
               
                 Thonzonium Bromide 
                 24.4 
                 32.9 
                 45.1 
                 28.0 
                 22.5 
                 36.7 
                 47.0 
                 18.4 
                 36.6 
                 47.0 
                 46.2 
                 39.4 
                 35.2 
               
               
                 Cinoxacin 
                 68.3 
                 66.2 
                 69.7 
                 64.0 
                 83.2 
                 67.1 
                 98.9 
                 71.5 
                 74.2 
                 74.9 
                 87.0 
                 97.0 
                 108.9 
               
               
                 Bekanamycin 
                 55.5 
                 73.6 
                 85.3 
                 95.2 
                 81.7 
                 80.8 
                 74.5 
                 76.2 
                 58.3 
                 57.5 
                 76.3 
                 96.9 
                 96.8 
               
               
                 Difloxacin HCl 
                 58.5 
                 96.7 
                 71.2 
                 130.0 
                 82.9 
                 77.5 
                 79.4 
                 52.0 
                 64.5 
                 52.3 
                 77.3 
                 95.7 
                 77.0 
               
               
                 Cephapirin Sodium 
                 50.2 
                 65.8 
                 79.8 
                 69.2 
                 79.8 
                 76.2 
                 69.1 
                 78.2 
                 57.7 
                 49.5 
                 82.3 
                 92.8 
                 84.3 
               
               
                 Clofoctol 
                 34.5 
                 61.0 
                 77.9 
                 58.0 
                 86.7 
                 77.0 
                 73.6 
                 72.3 
                 55.6 
                 48.1 
                 63.4 
                 74.7 
                 83.0 
               
               
                 Pasiniazid 
                 38.8 
                 79.9 
                 60.2 
                 70.5 
                 52.8 
                 69.8 
                 49.5 
                 47.8 
                 40.1 
                 44.7 
                 65.6 
                 56.5 
                 113.2 
               
               
                   
               
               
                   
                 A375 
                 HCT116(WT) 
                 HepG2 
                 HeLa 
                 AGS 
                 H1650 
                 MKN-45 
                 TSGH 
                 A549 
                 MCF7 
                 PC3 
                 LoVo 
                 HL-60 
               
               
                   
               
               
                 Curcumin 
                 104.1517 
                 93.59955 
                 98.32845 
                 66.17249 
                 72.20966 
                 74.6574 
                 46.36867 
                 95.41959 
                 104.8165 
                 61.78115 
                 77.8638 
                 80.01025 
                 111.3333 
               
               
                 Talc 
                 66.78463 
                 97.48187 
                 124.542 
                 80.03129 
                 86.17534 
                 88.30275 
                 63.44364 
                 91.07906 
                 52.4318 
                 47.10155 
                 45.60222 
                 74.11913 
                 99.89936 
               
               
                 Avobenzone (Parsol 1789) 
                 62.58342 
                 87.88148 
                 111.1525 
                 65.6383 
                 76.38487 
                 80.51988 
                 61.16856 
                 96.26068 
                 52.13581 
                 54.1091 
                 42.88069 
                 84.24497 
                 86.01705 
               
               
                 Meglumine 
                 78.19291 
                 92.70295 
                 90.78556 
                 74.0779 
                 95.03349 
                 61.97811 
                 74.64493 
                 109.0826 
                 107.6122 
                 97.02401 
                 76.80619 
                 78.35011 
                 114.1135 
               
               
                 Geniposide 
                 73.42172 
                 73.92127 
                 88.5582 
                 80.99412 
                 54.16912 
                 71.18227 
                 45.62227 
                 53.10121 
                 63.66648 
                 73.82923 
                 65.54175 
                 74.10151 
                 119.651 
               
               
                 Genipin 
                 78.03728 
                 82.7025 
                 87.05908 
                 74.51176 
                 49.56541 
                 69.45813 
                 54.06743 
                 67.65546 
                 61.77802 
                 71.66373 
                 71.60605 
                 74.63694 
                 116.7718 
               
               
                 Benzoic acid 
                 36.9762 
                 41.89746 
                 79.12599 
                 59.59074 
                 53.05571 
                 57.24681 
                 43.37741 
                 39.47556 
                 36.71191 
                 31.36544 
                 36.78594 
                 60.4637 
                 110.8349 
               
               
                 Coumarin 
                 156.6911 
                 93.73406 
                 100.212 
                 96.54225 
                 98.51982 
                 95.62174 
                 101.0172 
                 107.874 
                 91.82918 
                 100.5157 
                 86.27522 
                 88.27368 
                 102.1924 
               
               
                 Choline Chloride 
                 132.0856 
                 103.8256 
                 102.9483 
                 103.0871 
                 97.08145 
                 90.17561 
                 99.25918 
                 128.9261 
                 96.0435 
                 107.7357 
                 106.291 
                 76.68864 
                 91.11496 
               
               
                 1-Hexadecanol 
                 112.5688 
                 69.79481 
                 95.95113 
                 91.32686 
                 89.43803 
                 84.34979 
                 85.45997 
                 101.2905 
                 83.97244 
                 101.2146 
                 91.9098 
                 98.76884 
                 92.1751 
               
               
                 Sodium Gluconate 
                 115.9939 
                 89.09112 
                 95.30493 
                 72.9899 
                 90.82623 
                 94.61319 
                 93.00088 
                 97.38626 
                 91.87137 
                 94.7031 
                 78.05738 
                 100 
                 91.17986 
               
               
                 Trometamol 
                 125.5535 
                 90.41271 
                 96.65792 
                 90.91781 
                 78.14852 
                 95.40816 
                 88.29058 
                 102.4825 
                 79.48622 
                 98.80952 
                 97.0034 
                 67.96286 
                 91.28804 
               
               
                 Uracil 
                 98.2263 
                 94.33689 
                 100.1716 
                 106.5128 
                 82.94865 
                 91.82487 
                 100.9951 
                 104.0354 
                 80.53628 
                 103.1618 
                 162.9771 
                 70.22336 
                 98.69465 
               
               
                 Bemegride 
                 62.66055 
                 47.66404 
                 90.69063 
                 62.71891 
                 61.96688 
                 69.89796 
                 99.65723 
                 93.29615 
                 60.1772 
                 123.2745 
                 112.8373 
                 88.48897 
                 124.8233 
               
               
                 Isosorbide 
                 53.49235 
                 55.08927 
                 90.09491 
                 72.77899 
                 69.04165 
                 73.30327 
                 93.12251 
                 77.46063 
                 60.70692 
                 78.62927 
                 94.34111 
                 81.75457 
                 125.0541 
               
               
                 Dibenzothiophene 
                 70.59939 
                 52.65476 
                 89.09532 
                 94.58648 
                 59.24068 
                 76.0916 
                 92.06103 
                 88.1671 
                 62.3289 
                 71.42857 
                 80.23341 
                 79.70936 
                 110.1183 
               
               
                 Chlorocresol 
                 65.36391 
                 61.71458 
                 98.55614 
                 96.30577 
                 103.1193 
                 91.5401 
                 101.1499 
                 113.2437 
                 80.14251 
                 64.1604 
                 129.6864 
                 62.02234 
                 96.39406 
               
               
                 Sucralose 
                 83.29052 
                 54.79365 
                 95.26454 
                 77.9049 
                 66.70848 
                 72.0337 
                 94.09553 
                 94.33508 
                 74.32965 
                 71.17313 
                 78.84756 
                 73.77557 
                 88.54031 
               
               
                 Benzbromarone 
                 99.17644 
                 128.4237 
                 102.8409 
                 104.2825 
                 80.13169 
                 75.3432 
                 86.22105 
                 99.91064 
                 51.50565 
                 52.82563 
                 80.89452 
                 105.4056 
                 85.47609 
               
               
                 Nithiamide 
                 96.71824 
                 86.86044 
                 94.76461 
                 82.98817 
                 102.2262 
                 67.09287 
                 76.70771 
                 121.5449 
                 39.25136 
                 65.52619 
                 74.45062 
                 89.83966 
                 102.4575 
               
               
                 Alexidine HCl 
                 38.08335 
                 65.83932 
                 65.92938 
                 44.85207 
                 45.05644 
                 57.52355 
                 64.40926 
                 36.61636 
                 25.29486 
                 34.82775 
                 38.04292 
                 54.64359 
                 29.4161 
               
               
                 9-Aminoacridine 
                 36.38008 
                 70.50947 
                 63.45373 
                 43.57249 
                 42.76756 
                 56.94482 
                 63.10466 
                 34.63066 
                 25.8051 
                 34.12577 
                 38.65047 
                 58.52516 
                 28.83353 
               
               
                 Calcium Gluceptate 
                 36.96656 
                 74.09101 
                 76.87703 
                 43.92751 
                 79.67182 
                 54.25303 
                 74.23043 
                 33.80659 
                 24.91426 
                 34.24375 
                 37.91365 
                 55.29449 
                 113.4525 
               
               
                 Clopamide 
                 63.10207 
                 101.9268 
                 92.847 
                 87.0784 
                 50.28219 
                 53.97039 
                 89.43125 
                 58.96545 
                 32.42576 
                 33.3589 
                 40.32446 
                 54.32608 
                 102.2231 
               
               
                   
               
             
          
         
       
     
         [0047]    Repeated Experiment 
         [0048]    According to the listing antibiotic drug inhibit cancer cell growth results of Table 3, the inventors take the repeat experiment for checking effectively the inhibitory effect of cancer cell growth by the antibiotic drug. The results show as Table. 4. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
               
                 The results of antibiotic drug inhibiting cancer cell lines 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 AGS 
                 MKN-45 
                 A549 
                 H1650 
                 TSGH-8301 
                 T24 
                 HepG2 
                 Hep3B 
                 HCT116 
                 LoVo 
                 HeLa 
                 C-33A 
               
               
                   
               
               
                 paroxetine 
                 12.16 
                 40.49 
                 92.43 
                 56.85 
                 38.35 
                 99.95 
                 54.13 
                 66.07 
                 28.38 
                 57.97 
                 63.82 
                 33.19 
               
               
                 Cetrimonium Bromide 
                 20.83 
                 35.25 
                 20.71 
                 40.26 
                 22.33 
                 19.1 
                 56.6 
                 58.68 
                 19.31 
                 51.72 
                 20.73 
                 35.29 
               
               
                 Thonzonium Bromide 
                 14.37 
                 31.18 
                 15 
                 37.63 
                 16.72 
                 18.47 
                 47.73 
                 51.26 
                 18.75 
                 50.9 
                 20.28 
                 32.48 
               
               
                 Olanzapine (Zyprexa) 
                 121.8 
                 125.4 
                 105.8 
                 106.8 
                 151.6 
                 110.1 
                 114.1 
                 132.4 
                 124.1 
                 81.37 
                 121.2 
                 98.19 
               
               
                 Clomipramine 
                 122.1 
                 125.3 
                 86.37 
                 103.2 
                 139.2 
                 109.4 
                 106.4 
                 135.1 
                 137.2 
                 65.67 
                 113 
                 117.7 
               
               
                 hydrochloride  
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Anafranil) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amitriptyline HCl 
                 146 
                 134.6 
                 73.34 
                 111.1 
                 157.1 
                 97.45 
                 105.5 
                 123.9 
                 107.7 
                 90.47 
                 111.2 
                 100.2 
               
               
                 Escitalopram oxalate 
                 145.1 
                 127.1 
                 102.8 
                 92.11 
                 134.6 
                 97.65 
                 113.2 
                 133.8 
                 122.9 
                 89.35 
                 125.5 
                 110.1 
               
               
                 Ritonavir 
                 96.25 
                 95.79 
                 72.66 
                 78.24 
                 115.3 
                 97.34 
                 85.48 
                 101.8 
                 83.57 
                 90.21 
                 86.09 
                 111 
               
               
                 Entecavir hydrate 
                 88.67 
                 92.54 
                 104 
                 84.11 
                 103.4 
                 96.39 
                 88.91 
                 90.77 
                 99.92 
                 96.66 
                 76.9 
                 96.67 
               
               
                 Posaconazole 
                 65.68 
                 92.77 
                 18.12 
                 67.54 
                 81.89 
                 55.37 
                 57.82 
                 95.24 
                 51.57 
                 61.96 
                 49.41 
                 35.51 
               
               
                 Ivermectin 
                 79.82 
                 102.1 
                 33.35 
                 50.2 
                 63.74 
                 101.7 
                 65.3 
                 63.22 
                 62.7 
                 53.26 
                 58.86 
                 85.05 
               
               
                 Tigecycline 
                 90.64 
                 114 
                 91.48 
                 66.93 
                 112.7 
                 109.1 
                 97.2 
                 105.5 
                 89.69 
                 96.03 
                 102 
                 99.98 
               
               
                 Linezolid (Zyvox) 
                 104.4 
                 136.9 
                 82.14 
                 95.64 
                 99.71 
                 1141 
                 107.3 
                 99.88 
                 107.3 
                 89.47 
                 89.19 
                 132.2 
               
               
                 Telaprevir (VX-950) 
                 111 
                 107.4 
                 80.36 
                 107.3 
                 103.2 
                 114.7 
                 114 
                 121 
                 93.64 
                 87.03 
                 92.58 
                 102.5 
               
               
                 Saxagliptin (BMS- 
                 121.3 
                 117.7 
                 98.68 
                 101.5 
                 119.6 
                 90.82 
                 118 
                 122.9 
                 106.8 
                 82.99 
                 114.7 
                 104.4 
               
               
                 477118, Onglyza) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Nitazoxanide (Alinia, 
                 99.04 
                 97.28 
                 95.57 
                 85.86 
                 87.18 
                 76.47 
                 107.5 
                 106.8 
                 98.42 
                 94.76 
                 84.93 
                 103.9 
               
               
                 Annita) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amprenavir (Agenerase) 
                 98.57 
                 102.7 
                 79.88 
                 88.12 
                 96.1 
                 90.55 
                 94.54 
                 95.2 
                 94.49 
                 95.49 
                 67.87 
                 108.6 
               
               
                 Albendazole (Albenza) 
                 29.46 
                 62.34 
                 24.2 
                 41.75 
                 46.61 
                 37.98 
                 62.7 
                 61.38 
                 20.91 
                 50.79 
                 29.9 
                 42.62 
               
               
                 Nitrofurazone  
                 88.25 
                 86.77 
                 113.8 
                 67.33 
                 83.88 
                 87.38 
                 95.44 
                 95.27 
                 110.4 
                 84.8 
                 51.16 
                 83.2 
               
               
                 (Nitrofural) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Adefovir Dipivoxil 
                 78.05 
                 86.57 
                 76.71 
                 54.04 
                 69.95 
                 44.75 
                 80.14 
                 71.53 
                 55.44 
                 58.12 
                 77.42 
                 68.03 
               
               
                 (Preveon, Hepsera) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Rifapentine (Priftin) 
                 76.38 
                 98.6 
                 87.37 
                 68.97 
                 94.71 
                 86.32 
                 112.1 
                 110.1 
                 100.7 
                 93.47 
                 104.4 
                 91.74 
               
               
                 Trifluridine (Viroptic) 
                 83.23 
                 89.49 
                 61.63 
                 77.96 
                 86.44 
                 55.36 
                 85.57 
                 77.6 
                 51.5 
                 62.52 
                 86.89 
                 66.53 
               
               
                 Rifaximin (Xifaxan) 
                 98.11 
                 93.54 
                 107.7 
                 69.54 
                 114.5 
                 96.76 
                 115.4 
                 110.4 
                 100.8 
                 80.33 
                 106 
                 107.4 
               
               
                 Oxfendazole 
                 51.41 
                 79.88 
                 64.67 
                 63.95 
                 67.58 
                 70.17 
                 99.38 
                 106.8 
                 67.39 
                 73.69 
                 36.97 
                 86.44 
               
               
                 Albendazole Oxide 
                 80.02 
                 74.3 
                 95.47 
                 64.6 
                 63.26 
                 89.78 
                 92.92 
                 97.94 
                 91.27 
                 88.16 
                 49.41 
                 101.5 
               
               
                 (Ricobendazole) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Flubendazole  
                 28.25 
                 63.06 
                 22.71 
                 35.69 
                 45.64 
                 34.67 
                 56.8 
                 56.93 
                 20.63 
                 53.35 
                 25.78 
                 46.4 
               
               
                 (Flutelmium) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Oxibendazole 
                 37.57 
                 65.63 
                 23.97 
                 41.26 
                 48.57 
                 38.06 
                 64.49 
                 59.82 
                 22.07 
                 53.38 
                 29.28 
                 47.75 
               
               
                 Metronidazole (Flagyl) 
                 113.3 
                 107.8 
                 97.65 
                 87.17 
                 92.37 
                 93.83 
                 94.06 
                 92.33 
                 98.93 
                 118.5 
                 75.35 
                 113.7 
               
               
                 Tioconazole 
                 119.9 
                 99.88 
                 100.5 
                 90.33 
                 105.2 
                 88.81 
                 109.2 
                 120.1 
                 102.8 
                 99.79 
                 96.87 
                 114.4 
               
               
                 Sulfisoxazole 
                 108.5 
                 104.7 
                 104.7 
                 75.91 
                 104.6 
                 90.67 
                 122.1 
                 110 
                 97.9 
                 112.5 
                 120.2 
                 115.8 
               
               
                 Nystatin (Mycostatin) 
                 115 
                 95.89 
                 94.3 
                 72.42 
                 91.24 
                 76.44 
                 101.6 
                 108.8 
                 103 
                 102.5 
                 108.2 
                 105.3 
               
               
                 Levamisole  
                 120.5 
                 112.3 
                 104.9 
                 78.34 
                 106.8 
                 92.87 
                 127.7 
                 121.1 
                 116 
                 100.7 
                 137 
                 96.19 
               
               
                 Hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Ergamisol) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Miconazole nitrate 
                 113.7 
                 99.81 
                 97.27 
                 83.13 
                 102.3 
                 77.7 
                 108.3 
                 126.1 
                 121.5 
                 81.28 
                 95.73 
                 117.1 
               
               
                 Ammonium  
                 109.2 
                 96.41 
                 83.55 
                 76.88 
                 105.2 
                 107.9 
                 119.7 
                 102.1 
                 93.44 
                 100.4 
                 103.4 
                 108.4 
               
               
                 Glycyrrhizinate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (AMGZ) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amfebutamone  
                 116.9 
                 103.1 
                 69.1 
                 95.97 
                 115.8 
                 99.6 
                 92.33 
                 82.09 
                 78.27 
                 114.6 
                 84.46 
                 106.9 
               
               
                 (Bupropion) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Loperamide  
                 22.18 
                 61.54 
                 26.25 
                 41.28 
                 42.91 
                 73.49 
                 35.76 
                 50.16 
                 47.26 
                 49.29 
                 36.83 
                 39.63 
               
               
                 hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Mycophenolic 
                 31.68 
                 64.94 
                 38.97 
                 54.54 
                 57.45 
                 48.23 
                 62.08 
                 66.83 
                 43.07 
                 58.58 
                 46.1 
                 51.84 
               
               
                 (Mycophenolate) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cloxacillin sodium 
                 140.1 
                 111.3 
                 98.33 
                 86.43 
                 136.6 
                 100.9 
                 131 
                 118.4 
                 115.2 
                 98.38 
                 120.1 
                 104.6 
               
               
                 (Cloxacap) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amoxicillin  
                 128.2 
                 110.7 
                 101 
                 87.81 
                 129.6 
                 105.9 
                 124.5 
                 109.8 
                 112.2 
                 103.3 
                 112.6 
                 108.2 
               
               
                 sodium (Amox) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Tetracycline HCl 
                 93.99 
                 133 
                 99.68 
                 87.12 
                 102.6 
                 130.2 
                 106.3 
                 92.23 
                 114.1 
                 92.04 
                 78.95 
                 102.9 
               
               
                 Vancomycin HCl 
                 108.9 
                 116.9 
                 86.65 
                 82.92 
                 118 
                 95.32 
                 92.06 
                 94.6 
                 94.76 
                 101 
                 78.82 
                 100.6 
               
               
                 (Vancocin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Xylometazoline HCl 
                 125.1 
                 120.7 
                 83.01 
                 95.35 
                 121.9 
                 92.52 
                 106.1 
                 114 
                 101.4 
                 88.73 
                 117.3 
                 103.6 
               
               
                 Phenacetin 
                 121.7 
                 122.7 
                 87.62 
                 90.09 
                 128 
                 101 
                 121.1 
                 106.2 
                 102.4 
                 87.66 
                 109.9 
                 113.6 
               
               
                 Trazodone  
                 120.4 
                 108.2 
                 92.03 
                 82.39 
                 133.7 
                 105.5 
                 108.6 
                 109.5 
                 113.3 
                 88.78 
                 105.3 
                 112.2 
               
               
                 hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Desyrel) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Thiamphenicol 
                 140.3 
                 177 
                 97.41 
                 94.92 
                 136.8 
                 164 
                 143.9 
                 103.3 
                 150 
                 96.08 
                 90.82 
                 140.2 
               
               
                 (Thiophenicol) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ciclopirox ethanolamine 
                 36.59 
                 72.97 
                 23.67 
                 53.76 
                 43.63 
                 41.2 
                 102.4 
                 48.66 
                 29.52 
                 65.53 
                 41.02 
                 42.12 
               
               
                 Niclosamide (Niclocide) 
                 23.05 
                 50.74 
                 16.68 
                 36.77 
                 35.94 
                 26.49 
                 37.55 
                 60.79 
                 23.91 
                 41.95 
                 25.4 
                 39.49 
               
               
                 Etravirine (TMC125) 
                 49.66 
                 62.38 
                 37 
                 51.13 
                 56.13 
                 56.73 
                 68.31 
                 78.35 
                 54.08 
                 45.66 
                 47.73 
                 63.88 
               
               
                 Indacaterol Maleate 
                 50.2 
                 84.53 
                 79.64 
                 86.56 
                 101.4 
                 122 
                 84.41 
                 97.64 
                 91.94 
                 79.12 
                 96.62 
                 94.35 
               
               
                 Pentamidine 
                 92.36 
                 97.29 
                 35.42 
                 68.55 
                 82.65 
                 122.8 
                 69.12 
                 72.02 
                 100.5 
                 63.36 
                 44.6 
                 65.68 
               
               
                 Clofazimine 
                 78.77 
                 107.8 
                 87.1 
                 92.17 
                 110.6 
                 74.06 
                 90.41 
                 91.61 
                 82.94 
                 83.4 
                 94.34 
                 111.4 
               
               
                 Azithromycin Dihydrate 
                 77.25 
                 95.84 
                 66.29 
                 98.63 
                 118.6 
                 111.5 
                 91.4 
                 109.1 
                 80.71 
                 79.22 
                 105.4 
                 92.62 
               
               
                 Chlortetracycline HCl 
                 99.94 
                 142.1 
                 99.29 
                 88.54 
                 152.5 
                 122.1 
                 112.6 
                 117.2 
                 91.53 
                 74.36 
                 83.96 
                 88.03 
               
               
                 Benzylpenicillin sodium 
                 110.3 
                 123.7 
                 97.21 
                 121.3 
                 131.3 
                 107.9 
                 108.4 
                 112.9 
                 93.95 
                 78.27 
                 106.9 
                 109.6 
               
               
                 Chlorquinaldol 
                 53.88 
                 92.37 
                 37.8 
                 75.19 
                 86.98 
                 50.57 
                 81.99 
                 105.1 
                 38.51 
                 45.8 
                 64.94 
                 47.46 
               
               
                 Primaquine Diphosphate 
                 37.08 
                 63.06 
                 47.37 
                 66.76 
                 51.51 
                 72.63 
                 81.04 
                 115.2 
                 60.94 
                 81.19 
                 61.17 
                 96.76 
               
               
                 Colistimethate Sodium 
                 87.05 
                 104.8 
                 89.46 
                 82.62 
                 111.7 
                 108.3 
                 107.4 
                 102.2 
                 86.11 
                 85.06 
                 77.79 
                 107.5 
               
               
                 Clofoctol 
                 83.89 
                 117 
                 90.58 
                 69.57 
                 109.3 
                 90.83 
                 113.7 
                 135.4 
                 76.64 
                 67.1 
                 98.02 
                 116.7 
               
               
                 Rosuvastatin calcium 
                 104.4 
                 109.9 
                 95.1 
                 76.74 
                 112.6 
                 75.94 
                 108 
                 109.3 
                 85.62 
                 103.1 
                 97.1 
                 100.8 
               
               
                 (Crestor) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Mevastatin 
                 71.25 
                 92.72 
                 101.3 
                 69.43 
                 94.4 
                 67.51 
                 98.7 
                 97.65 
                 73.63 
                 90.48 
                 90.53 
                 101.6 
               
               
                   
               
               
                   
                   
                   
                 MDA- 
                 NIH- 
                 TOV- 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 PC-3 
                 MCF-7 
                 MB231 
                 OVCAR-3 
                 21G 
                 AsPC-1 
                 BxPC-3 
                 SAS 
                 U2OS 
                 A375 
                 BCC 
                 786-O 
               
               
                   
               
               
                 paroxetine 
                 44.06 
                 51.17 
                 41.76 
                 85.96 
                 87.12 
                 76.98 
                 77.74 
                 51.5 
                 33.19 
                 43.83 
                 58.23 
                 24.02 
               
               
                 Cetrimonium Bromide 
                 28.53 
                 47.47 
                 33.73 
                 56.47 
                 15.69 
                 30.03 
                 25.89 
                 21.73 
                 36.44 
                 12.93 
                 23.59 
                 16.85 
               
               
                 Thonzonium Bromide 
                 29.26 
                 41.03 
                 33.11 
                 55.67 
                 17.42 
                 27.56 
                 24.44 
                 20.45 
                 31.69 
                 12.36 
                 23.45 
                 16.75 
               
               
                 Olanzapine (Zyprexa) 
                 112.8 
                 86.77 
                 111.1 
                 96.85 
                 105 
                 84.25 
                 65.94 
                 59.27 
                 65.96 
                 98.29 
                 100.7 
                 91.78 
               
               
                 Clomipramine 
                 91.19 
                 65.87 
                 117.1 
                 100.6 
                 118.2 
                 77.17 
                 78.33 
                 51.61 
                 58.43 
                 100.9 
                 124.3 
                 80.31 
               
               
                 hydrochloride  
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Anafranil) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amitriptyline HCl 
                 99.38 
                 67.66 
                 105.9 
                 103.5 
                 117.5 
                 73.08 
                 67.15 
                 67.55 
                 68.5 
                 94.3 
                 112.8 
                 85.52 
               
               
                 Escitalopram oxalate 
                 120.1 
                 80.08 
                 110.7 
                 100.9 
                 117.4 
                 80.26 
                 68.08 
                 65.27 
                 62.23 
                 100.8 
                 102.5 
                 88.82 
               
               
                 Ritonavir 
                 92.69 
                 67.01 
                 102.1 
                 92.21 
                 72.73 
                 88.64 
                 89.57 
                 73.17 
                 87.1 
                 80.26 
                 86.4 
                 102.5 
               
               
                 Entecavir hydrate 
                 118.3 
                 92.93 
                 98.9 
                 108.6 
                 85.54 
                 98.43 
                 97.15 
                 74.57 
                 85.34 
                 89.05 
                 69.5 
                 92.66 
               
               
                 Posaconazole 
                 52.06 
                 48.04 
                 60.36 
                 62.31 
                 37.26 
                 32.16 
                 42.56 
                 26.65 
                 38.87 
                 47.91 
                 43.55 
                 18.14 
               
               
                 Ivermectin 
                 27.87 
                 48.13 
                 83.03 
                 61.85 
                 42.41 
                 41.75 
                 65.76 
                 41.52 
                 50.69 
                 44.36 
                 33.64 
                 55.69 
               
               
                 Tigecycline 
                 112 
                 79.12 
                 93.36 
                 91.12 
                 67.14 
                 86.48 
                 75.56 
                 66.21 
                 83.95 
                 83.22 
                 79.89 
                 100.5 
               
               
                 Linezolid (Zyvox) 
                 115.3 
                 73.07 
                 96.16 
                 109.6 
                 78.16 
                 92.58 
                 95.64 
                 83.98 
                 99.83 
                 82.8 
                 67.21 
                 98.62 
               
               
                 Telaprevir (VX-950) 
                 89.23 
                 76.39 
                 95.57 
                 95.59 
                 81.61 
                 69.3 
                 63.89 
                 67.61 
                 63.41 
                 105.2 
                 92.5 
                 94.85 
               
               
                 Saxagliptin (BMS- 
                 112 
                 83.97 
                 102 
                 114.2 
                 91.41 
                 75.97 
                 83.75 
                 62.71 
                 62.9 
                 111.4 
                 88.11 
                 98.33 
               
               
                 477118, Onglyza) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Nitazoxanide (Alinia, 
                 90.27 
                 79.28 
                 91.23 
                 104.5 
                 62.56 
                 84.09 
                 89.5 
                 78.89 
                 83.33 
                 94.2 
                 76 
                 44.2 
               
               
                 Annita) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amprenavir (Agenerase) 
                 87.44 
                 68.35 
                 83.45 
                 105.9 
                 96.99 
                 90.4 
                 74.63 
                 83.28 
                 101.1 
                 88.08 
                 74.5 
                 96.74 
               
               
                 Albendazole (Albenza) 
                 37.99 
                 69.83 
                 44.52 
                 52.49 
                 29.79 
                 35.28 
                 36.62 
                 36.08 
                 50.07 
                 36.21 
                 31.25 
                 21.55 
               
               
                 Nitrofurazone  
                 98.64 
                 106.6 
                 83.95 
                 99.51 
                 95.65 
                 76.69 
                 71.62 
                 92.3 
                 92.43 
                 94.69 
                 92.98 
                 89.97 
               
               
                 (Nitrofural) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Adefovir Dipivoxil 
                 74.85 
                 75.5 
                 71.86 
                 78.82 
                 77.26 
                 48.67 
                 56.92 
                 40.03 
                 68.48 
                 37.74 
                 38.85 
                 25.95 
               
               
                 (Preveon, Hepsera) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Rifapentine (Priftin) 
                 98.43 
                 84.1 
                 93.34 
                 104.1 
                 79.65 
                 78.22 
                 73.95 
                 85.36 
                 87.2 
                 98.17 
                 85.71 
                 85.92 
               
               
                 Trifluridine (Viroptic) 
                 101.2 
                 79.64 
                 75.06 
                 105.1 
                 81.44 
                 62.13 
                 73.12 
                 33.49 
                 61.22 
                 59.44 
                 83.3 
                 37.87 
               
               
                 Rifaximin (Xifaxan) 
                 95.28 
                 89.94 
                 98.66 
                 100.1 
                 87.95 
                 71.17 
                 88.95 
                 69.8 
                 72.88 
                 98.24 
                 81.83 
                 87.56 
               
               
                 Oxfendazole 
                 72.72 
                 64.63 
                 73.93 
                 62.17 
                 65.1 
                 50.85 
                 54.96 
                 72.33 
                 83.4 
                 59.67 
                 55.28 
                 72.33 
               
               
                 Albendazole Oxide 
                 78.73 
                 68.26 
                 81.12 
                 72.07 
                 76.35 
                 67.6 
                 50.24 
                 92.4 
                 84.78 
                 66.51 
                 57.15 
                 86.08 
               
               
                 (Ricobendazole) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Flubendazole  
                 32.11 
                 55.01 
                 43.43 
                 59.15 
                 24.84 
                 35.53 
                 32.76 
                 45.16 
                 48.74 
                 30.32 
                 31.79 
                 20.97 
               
               
                 (Flutelmium) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Oxibendazole 
                 38.91 
                 60.91 
                 48.93 
                 54.83 
                 26.64 
                 32.96 
                 29.09 
                 41.22 
                 46.65 
                 31.81 
                 34.31 
                 18.51 
               
               
                 Metronidazole (Flagyl) 
                 95.57 
                 77.27 
                 93.29 
                 109.5 
                 95.83 
                 83.06 
                 83.62 
                 112.5 
                 99.63 
                 74.71 
                 68.23 
                 92.02 
               
               
                 Tioconazole 
                 103.6 
                 97.81 
                 103.1 
                 92.55 
                 78.52 
                 80.07 
                 69.23 
                 93.62 
                 92.4 
                 97.82 
                 87.75 
                 75.56 
               
               
                 Sulfisoxazole 
                 110.6 
                 106.2 
                 104.1 
                 108.2 
                 84.49 
                 80.08 
                 67.12 
                 101.1 
                 88.64 
                 106.6 
                 102.3 
                 93.27 
               
               
                 Nystatin (Mycostatin) 
                 109.1 
                 89.88 
                 86.09 
                 108.3 
                 74.99 
                 75.83 
                 69.94 
                 97.09 
                 76.11 
                 99.37 
                 92.4 
                 89.48 
               
               
                 Levamisole  
                 125.7 
                 102.4 
                 102.7 
                 105.6 
                 83.45 
                 85.72 
                 68.02 
                 89.56 
                 79.87 
                 113.9 
                 114.1 
                 93.24 
               
               
                 Hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Ergamisol) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Miconazole nitrate 
                 115.7 
                 95.64 
                 106.6 
                 94.77 
                 80.62 
                 75.5 
                 65.27 
                 69.58 
                 64.24 
                 100.3 
                 80.67 
                 75.24 
               
               
                 Ammonium  
                 120.7 
                 69.06 
                 98.74 
                 101 
                 74.39 
                 100.6 
                 102.8 
                 83.22 
                 78.97 
                 100.5 
                 93.09 
                 102.9 
               
               
                 Glycyrrhizinate 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (AMGZ) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amfebutamone 
                 87.88 
                 68.96 
                 80.34 
                 108.8 
                 97.53 
                 84.27 
                 79.56 
                 110.2 
                 92.31 
                 88.44 
                 77.45 
                 102.7 
               
               
                 (Bupropion) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Loperamide  
                 41.61 
                 36.25 
                 72.53 
                 75.46 
                 24.22 
                 47.5 
                 35.74 
                 31.75 
                 31.99 
                 34.26 
                 51.45 
                 40.91 
               
               
                 hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Mycophenolic 
                 55.4 
                 70.27 
                 56.93 
                 59.03 
                 40.28 
                 48.07 
                 45.69 
                 43.23 
                 43.23 
                 28.9 
                 44.63 
                 24.73 
               
               
                 (Mycophenolate) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Cloxacillin sodium 
                 130.8 
                 103.7 
                 101.6 
                 106.9 
                 105.9 
                 80 
                 69.13 
                 70.4 
                 69.87 
                 110.7 
                 116.6 
                 106.1 
               
               
                 (Cloxacap) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Amoxicillin sodium 
                 127.2 
                 98.11 
                 103.4 
                 101.8 
                 101.8 
                 88.13 
                 71.08 
                 66.94 
                 65.21 
                 115.9 
                 115.1 
                 98.18 
               
               
                 (Amox) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Tetracycline HCl 
                 104.5 
                 93.11 
                 88.07 
                 104.5 
                 81.94 
                 96.69 
                 77.67 
                 79.25 
                 53.3 
                 82.79 
                 100.5 
                 99.91 
               
               
                 Vancomycin HCl 
                 104.2 
                 91.83 
                 90.26 
                 105.6 
                 97.4 
                 85.55 
                 79.16 
                 102 
                 62.87 
                 83.4 
                 96.78 
                 102.3 
               
               
                 (Vancocin) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Xylometazoline HCl 
                 116.1 
                 90.08 
                 96.3 
                 102.5 
                 92.29 
                 82.83 
                 72.93 
                 76.43 
                 60.23 
                 101.9 
                 116 
                 100.4 
               
               
                 Phenacetin 
                 133.3 
                 92.88 
                 91.69 
                 105.1 
                 95.75 
                 90.53 
                 73.24 
                 81.9 
                 63.91 
                 106.3 
                 118.8 
                 91.99 
               
               
                 Trazodone  
                 126 
                 97.82 
                 87.8 
                 102.9 
                 106.6 
                 89.4 
                 73.46 
                 58.38 
                 57.56 
                 111.2 
                 113.5 
                 95.49 
               
               
                 hydrochloride 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 (Desyrel) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Thiamphenicol 
                 150.2 
                 89.24 
                 95.4 
                 115.7 
                 105.7 
                 102.5 
                 86.08 
                 54.04 
                 51.12 
                 112 
                 111.8 
                 93.48 
               
               
                 (Thiophenicol) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ciclopirox ethanolamine 
                 54.81 
                 53.67 
                 48.29 
                 66.99 
                 28.95 
                 46.57 
                 47.7 
                 31.98 
                 51.75 
                 21.76 
                 29.08 
                 18.27 
               
               
                 Niclosamide (Niclocide) 
                 42.84 
                 33.36 
                 37.69 
                 54.68 
                 17.59 
                 40.72 
                 41.93 
                 23.94 
                 26.74 
                 20.26 
                 30.66 
                 25.52 
               
               
                 Etravirine (TMC125) 
                 53.42 
                 56.33 
                 95.38 
                 64.29 
                 28.26 
                 41.11 
                 41.88 
                 34.01 
                 36.38 
                 37.32 
                 46.3 
                 59.38 
               
               
                 Indacaterol Maleate 
                 100.3 
                 72.48 
                 102.6 
                 79.3 
                 95.33 
                 85.38 
                 91.37 
                 61.71 
                 62.58 
                 87.23 
                 82.13 
                 82.57 
               
               
                 Pentamidine 
                 70.35 
                 60.46 
                 79 
                 90.88 
                 82.91 
                 66.18 
                 55.02 
                 50.89 
                 43.93 
                 49.78 
                 45.83 
                 67.31 
               
               
                 Clofazimine 
                 105.9 
                 74.24 
                 102.4 
                 97.28 
                 65.06 
                 76.57 
                 72.2 
                 75.16 
                 80.57 
                 81.2 
                 72.91 
                 82.51 
               
               
                 Azithromycin Dihydrate 
                 97.15 
                 62.3 
                 97.76 
                 94.01 
                 89.64 
                 75.31 
                 71.29 
                 49.99 
                 70.34 
                 97.37 
                 70.64 
                 91.04 
               
               
                 Chlortetracycline HCl 
                 107.5 
                 93.38 
                 83.24 
                 99.29 
                 92.2 
                 82.06 
                 63.71 
                 97.44 
                 80.27 
                 108 
                 97.1 
                 91.41 
               
               
                 Benzylpenicillin sodium 
                 105.8 
                 86.92 
                 94.7 
                 110.4 
                 111.9 
                 101.4 
                 95.32 
                 66.96 
                 71.55 
                 112.6 
                 97.68 
                 93.15 
               
               
                 Chlorquinaldol 
                 66.42 
                 30.18 
                 65.02 
                 78.08 
                 40.07 
                 62.79 
                 53.91 
                 20.58 
                 32.44 
                 35.48 
                 42.95 
                 41.77 
               
               
                 Primaquine Diphosphate 
                 65.67 
                 50.72 
                 65.44 
                 60.19 
                 54.76 
                 66.47 
                 49.82 
                 59.86 
                 59.63 
                 38.67 
                 35.93 
                 81.46 
               
               
                 Colistimethate Sodium 
                 101.1 
                 74.61 
                 76.75 
                 103.4 
                 64.02 
                 82.31 
                 76.87 
                 77.78 
                 83.33 
                 94.89 
                 77.04 
                 86.46 
               
               
                 Clofoctol 
                 110.3 
                 83.02 
                 102.1 
                 97.78 
                 73.11 
                 78.69 
                 65.81 
                 73.17 
                 74.92 
                 108.6 
                 94.57 
                 105.4 
               
               
                 Rosuvastatin calcium 
                 95.68 
                 85.86 
                 90.19 
                 102.2 
                 80.39 
                 80.17 
                 65.52 
                 93.28 
                 101.7 
                 105.1 
                 103.5 
                 92.53 
               
               
                 (Crestor) 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Mevastatin 
                 65.61 
                 77.77 
                 56.06 
                 100.1 
                 44.67 
                 72.3 
                 83.58 
                 81.01 
                 85.28 
                 30.91 
                 29.83 
                 48