Datasets:

SkyHuReal

/

DrugBank-Alpaca

like 8

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.

<calcium, mechanism, EMCYT>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone.

<allopurinol, effect, ampicillin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.

<ampicillin, effect, allopurinol>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In common with other broad-spectrum antibiotics, AUGMENTIN XR may reduce the efficacy of oral contraceptives

<broad-spectrum antibiotics, effect, contraceptives>, <AUGMENTIN XR, effect, contraceptives>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Particular caution is necessary when using ROMAZICON in cases of mixed drug overdosage since the toxic effects (such as convulsions and cardiac dysrhythmias) of other drugs taken in overdose (especially cyclic antidepressants) may emerge with the reversal of the benzodiazepine effect by flumazenil.

<ROMAZICON, effect, cyclic antidepressants>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Although ROMAZICON exerts a slight intrinsic anticonvulsant effect, its abrupt suppression of the protective effect of a benzodiazepine agonist can give rise to convulsions in epileptic patients.

<ROMAZICON, effect, benzodiazepine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

ROMAZICON blocks the central effects of benzodiazepines by competitive interaction at the receptor level.

<ROMAZICON, effect, benzodiazepines>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolopyridazines and others, are also blocked by ROMAZICON.

<zopiclone, effect, ROMAZICON>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Caution is advised when TRISENOX is coadministered with other medications that can prolong the QT interval (e.g. certain antiarrhythmics or thioridazine) or lead to electrolyte abnormalities (such as diuretics or amphotericin B).

<TRISENOX, advise, antiarrhythmics>, <TRISENOX, advise, thioridazine>, <TRISENOX, advise, diuretics>, <TRISENOX, advise, amphotericin B>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy.

<steroids, effect, aspirin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Barbiturates, phenytoin, or rifampin increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.

<Barbiturates, mechanism, fludrocortisone acetate>, <phenytoin, mechanism, fludrocortisone acetate>, <rifampin, mechanism, fludrocortisone acetate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Oxytocin or other oxytocics (concurrent use with dinoprost may result in uterine hypertonus, possibly causing uterine rupture or cervical laceration, especially in the absence of adequate cervical dilatation;

<Oxytocin, effect, dinoprost>, <oxytocics, effect, dinoprost>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Acetaminophen: A report of severe acetaminophen toxicity was reported in a patient receiving Isoniazid.

<acetaminophen, effect, Isoniazid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

It is believed that the toxicity may have resulted from a previously unrecognized interaction between isoniazid and acetaminophen and a molecular basis for this interaction has been proposed.

<isoniazid, effect, acetaminophen>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Furthermore it has been proposed that isoniazid resulted In induction of P-450IIE1 in the patients liver which, in turn, resulted in a greater proportion of the ingested acetaminophen being converted to the toxic metabolites.

<isoniazid, mechanism, acetaminophen>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Carbamazepine: Isoniazid is known to slow the metabolism of carbamazepine and increase its serum levels Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely, and appropriate dosage adjustment of the anticonvulsant should be made.

<Isoniazid, mechanism, carbamazepine>, <Carbamazepine, advise, isoniazid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Ketoconazole: Potential interaction of Ketoconazole and Isoniazid may exist.

<Ketoconazole, int, Isoniazid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phenytoin: Isoniazid may increase serum levels of phenytoin.

<Isoniazid, mechanism, phenytoin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therophylline: A recent study has shown that concomitan administration of isoniazid and theophylline may cause elevated plasma levels of theophylline, and in some instances a slight decrease in the elimination of isoniazid.

<isoniazid, mechanism, theophylline>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Valproate: A recent case study has shown a possible increase in the plasma level of valproate when co administered with isoniazid.

<valproate, mechanism, isoniazid>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Plasma valproate concentration should be monitored when isoniazid and valproate are co administered, and appropriate dosage adjustments of valproate should be made.

<isoniazid, advise, valproate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Co-administration of MYOBLOC and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like compounds) should only be performed with caution as the effect of the toxin may be potentiated.

<MYOBLOC, advise, aminoglycosides>, <MYOBLOC, advise, curare-like compounds>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Hormonal Contraceptives, Including Oral, Injectable, Transdermal, and Implantable Contraceptives: An interaction study demonstrated that co-administration of bosentan and the oral hormonal contraceptive Ortho-Novum produced average decreases of norethindrone and ethinyl estradiol levels of 14% and 31%, respectively.

<bosentan, mechanism, Ortho-Novum>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, hormonal contraceptives, including oral, injectable, transdermal, and implantable forms, may not be reliable when TRACLEER is co-administered.

<hormonal contraceptives, effect, TRACLEER>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Steady-state bosentan plasma concentrations were 3- to 4-fold higher than in the absence of cyclosporine A.

<bosentan, mechanism, cyclosporine A>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The concomitant administration of bosentan and cyclosporine A is contraindicated.

<bosentan, advise, cyclosporine A>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Co-administration of bosentan decreased the plasma concentrations of cyclosporine A (a CYP3A4 substrate) by approximately 50%.

<bosentan, mechanism, cyclosporine A>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Co-administration of tacrolimus and bosentan resulted in markedly increased plasma concentrations of bosentan in animals.

<tacrolimus, mechanism, bosentan>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Caution should be exercised if tacrolimus and bosentan are used together.

<tacrolimus, advise, bosentan>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, the concomitant administration of TRACLEER and glyburide is contraindicated, and alternative hypoglycemic agents should be considered.

<TRACLEER, advise, glyburide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Co-administration of bosentan decreased the plasma concentrations of glyburide by approximately 40%.

<bosentan, mechanism, glyburide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Bosentan is also expected to reduce plasma concentrations of other oral hypoglycemic agents that are predominantly metabolized by CYP2C9 or CYP3A4.

<Bosentan, mechanism, hypoglycemic agents>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Ketoconazole: Co-administration of bosentan 125 mg b.i.d. and ketoconazole, a potent CYP3A4 inhibitor, increased the plasma concentrations of bosentan by approximately 2-fold.

<bosentan, mechanism, ketoconazole>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Simvastatin and Other Statins: Co-administration of bosentan decreased the plasma concentrations of simvastatin (a CYP3A4 substrate), and its active -hydroxy acid metabolite, by approximately 50%.

<bosentan, mechanism, simvastatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Bosentan is also expected to reduce plasma concentrations of other statins that have significant metabolism by CYP3A4, such as lovastatin and atorvastatin.

<Bosentan, mechanism, statins>, <Bosentan, mechanism, lovastatin>, <Bosentan, mechanism, atorvastatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Patients using CYP3A4 metabolized statins should have cholesterol levels monitored after TRACLEER is initiated to see whether the statin dose needs adjustment.

<statins, advise, TRACLEER>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Warfarin: Co-administration of bosentan 500 mg b.i.d. for 6 days decreased the plasma concentrations of both S-warfarin (a CYP2C9 substrate) and R-warfarin (a CYP3A4 substrate) by 29 and 38%, respectively.

<bosentan, mechanism, S-warfarin>, <bosentan, mechanism, R-warfarin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, the potential exists for a drug interaction between WELLBUTRIN and drugs that affect the CYP2B6 isoenzyme (e.g., orphenadrine and cyclophosphamide).

<WELLBUTRIN, int, orphenadrine>, <WELLBUTRIN, int, cyclophosphamide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine, phenobarbital, phenytoin).

<bupropion, mechanism, carbamazepine>, <bupropion, mechanism, phenobarbital>, <bupropion, mechanism, phenytoin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively.

<bupropion, mechanism, desipramine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, co-administration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide), should be approached with caution and should be initiated at the lower end of the dose range of the concomitant medication.

<bupropion, advise, antidepressants>, <bupropion, advise, nortriptyline>, <bupropion, advise, imipramine>, <bupropion, advise, desipramine>, <bupropion, advise, paroxetine>, <bupropion, advise, fluoxetine>, <bupropion, advise, sertraline>, <bupropion, advise, antipsychotics>, <bupropion, advise, haloperidol>, <bupropion, advise, risperidone>, <bupropion, advise, thioridazine>, <bupropion, advise, beta-blockers>, <bupropion, advise, metoprolol>, <bupropion, advise, Type 1C antiarrhythmics>, <bupropion, advise, propafenone>, <bupropion, advise, flecainide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

MAO Inhibitors: Studies in animals demonstrate that the acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine .

<bupropion, effect, phenelzine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Levodopa and Amantadine: Limited clinical data suggest a higher incidence of adverse experiences in patients receiving bupropion concurrently with either levodopa or amantadine.

<bupropion, effect, levodopa>, <bupropion, effect, amantadine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Administration of WELLBUTRIN Tablets to patients receiving either levodopa or amantadine concurrently should be undertaken with caution, using small initial doses and small gradual dose increases.

<WELLBUTRIN, advise, levodopa>, <WELLBUTRIN, advise, amantadine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Drugs that Lower Seizure Threshold: Concurrent administration of WELLBUTRIN and agents (e.g., antipsychotics, other antidepressants, theophylline, systemic steroids, etc.) that lower seizure threshold should be undertaken only with extreme caution.

<WELLBUTRIN, advise, antipsychotics>, <WELLBUTRIN, advise, antidepressants>, <WELLBUTRIN, advise, theophylline>, <WELLBUTRIN, advise, steroids>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Alcohol: In post-marketing experience, there have been rare reports of adverse neuropsychiatric events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with WELLBUTRIN.

<alcohol, effect, WELLBUTRIN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The consumption of alcohol during treatment with WELLBUTRIN should be minimized or avoided (also see a href= bupropz_od.htm#CI CONTRAINDICATIONS)

<alcohol, advise, WELLBUTRIN>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concurrent administration of a TNF antagonist with ORENCIA has been associated with an increased risk of serious infections and no significant additional efficacy over use of the TNF antagonists alone.

<TNF antagonist, effect, ORENCIA>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concurrent therapy with ORENCIA and TNF antagonists is not recommended.

<ORENCIA, advise, TNF antagonists>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

There is insufficient experience to assess the safety and efficacy of ORENCIA administered concurrently with anakinra, and therefore such use is not recommended.

<ORENCIA, advise, anakinra>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Cholestyramine and Charcoal Administration of cholestyramine or activated charcoal in patients (n=13) and volunteers (n=96) resulted in a rapid and significant decrease in plasma M1 (the active metabolite of leflunomide) concentration .

<cholestyramine, mechanism, leflunomide>, <activated charcoal, mechanism, leflunomide>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In a small (n=30) combination study of ARAVA with methotrexate, a 2- to 3-fold elevation in liver enzymes was seen in 5 of 30 patients.

<ARAVA, effect, methotrexate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Rifampin: Following concomitant administration of a single dose of ARAVA to subjects receiving multiple doses of rifampin, M1 peak levels were increased (~40%) over those seen when ARAVA was given alone.

<ARAVA, mechanism, rifampin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Because of the potential for ARAVA levels to continue to increase with multiple dosing, caution should be used if patients are to be receiving both ARAVA and rifampin.

<ARAVA, advise, rifampin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Warfarin: Increased INR (International Normalized Ratio) when ARAVA and warfarin were co-administered has been rarely reported.

<ARAVA, effect, warfarin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Animal studies indicate that dobutamine may be ineffective if the patient has recently received a b-blocking drug.

<dobutamine, effect, b-blocking drug>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when either drug is used alone.

<dobutamine, effect, nitroprusside>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, when heparin sodium is given with dicumarol or warfarin sodium, a period of at least 5 hours after the last intravenous dose or 24 hours after the last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained.

<heparin sodium, advise, dicumarol>, <heparin sodium, advise, warfarin sodium>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Platelet inhibitors: Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.

<acetylsalicylic acid, effect, heparin sodium>, <dextran, effect, heparin sodium>, <phenylbutazone, effect, heparin sodium>, <ibuprofen, effect, heparin sodium>, <indomethacin, effect, heparin sodium>, <dipyridamole, effect, heparin sodium>, <hydroxychloroquine, effect, heparin sodium>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The anticoagulant effect of heparin is enhanced by concurrent treatment with antithrombin III (human) in patients with hereditary antithrombin III deficiency.

<heparin, effect, antithrombin III>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Thus in order to avoid bleeding, reduced dosage of heparin is recommended during treatment with antithrombin III (human).

<heparin, advise, antithrombin III>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Drugs Decreasing Heparin Effect: Digitalis, tetracyclines, nicotine, or antihistamines may partially counteract the anticoagulant action of heparin sodium.

<Digitalis, effect, heparin sodium>, <tetracyclines, effect, heparin sodium>, <nicotine, effect, heparin sodium>, <antihistamines, effect, heparin sodium>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Steady-state serum concentrations of tricyclic antidepressants are reported to fluctuate significantly when cimetidine is either added or deleted from the drug regimen.

<tricyclic antidepressants, mechanism, cimetidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Serious anticholinergic symptoms (severe dry mouth, urinary retention, blurred vision) have been associated with elevations in the serum levels of tricyclic antidepressants when cimetidine is added to the drug regimen.

<tricyclic antidepressants, effect, cimetidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In addition, higher-than expected steady-state serum concentrations of tricyclic antidepressants have been observed when therapy is initiated in patients already taking cimetidine.

<tricyclic antidepressants, mechanism, cimetidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

In well-controlled patients undergoing concurrent therapy with cimetidine, a decrease in the steady-state serum concentrations of tricyclic antidepressants may occur when cime-tidine therapy is discontinued.

<cimetidine, mechanism, tricyclic antidepressants>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The therapeutic efficacy of tricyclic antidepressants may be compromised in these patients when cimetidine is discontinued.

<tricyclic antidepressants, effect, cimetidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

There have been greater than 2-fold increases in previously stable plasma levels of other antidepressants, including nortriptyline, when fluoxetine hydrochloride has been administered in combination with these agents.

<antidepressants, mechanism, fluoxetine hydrochloride>, <nortriptyline, mechanism, fluoxetine hydrochloride>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Administration of reserpine during therapy with a tricyclic antidepressant has been shown to produce a stimulating effect in some depressed patients.

<reserpine, effect, tricyclic antidepressant>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Close supervision and careful adjustment of the dosage are required when nortriptyline hydrochloride is used with other anticholinergic drugs or sympathomimetic drugs.

<nortriptyline hydrochloride, advise, anticholinergic drugs>, <nortriptyline hydrochloride, advise, sympathomimetic drugs>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, co-administration of tricyclic antidepressants with other drugs that are metabolized by this isoenzyme, including other antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (eg, propafenone, flecainide, and encainide), or that inhibit this enzyme (eg, quinidine), should be approached with caution.

<tricyclic antidepressants, advise, antidepressants>, <tricyclic antidepressants, advise, phenothiazines>, <tricyclic antidepressants, advise, carbamazepine>, <tricyclic antidepressants, advise, Type 1C antiarrhythmics>, <tricyclic antidepressants, advise, propafenone>, <tricyclic antidepressants, advise, flecainide>, <tricyclic antidepressants, advise, encainide>, <tricyclic antidepressants, advise, quinidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Although specific drug interaction studies have not been conducted with ALPHAGAN P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.

<ALPHAGAN P, advise, CNS depressants>, <ALPHAGAN P, advise, alcohol>, <ALPHAGAN P, advise, barbiturates>, <ALPHAGAN P, advise, opiates>, <ALPHAGAN P, advise, sedatives>, <ALPHAGAN P, advise, anesthetics>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN P in humans can lead to resulting interference with the IOP lowering effect.

<Tricyclic antidepressants, effect, clonidine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Oral Anticoagulants CAUTION SHOULD BE EXERCISED WHEN COUMARIN ANTICOAGULANTS ARE GIVEN IN CONJUNCTION WITH TRICOR.

<COUMARIN ANTICOAGULANTS, advise, TRICOR>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

HMG-CoA reductase inhibitors: The combined use of TRICOR and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.

<TRICOR, advise, HMG-CoA reductase inhibitors>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Resins: Since bile acid sequestrants may bind other drugs given concurrently, patients should take TRICOR at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption.

<TRICOR, mechanism, bile acid binding resin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Cyclosporine: Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including TRICOR, there is a risk that an interaction will lead to deterioration.

<cyclosporine, effect, fibrate drugs>, <cyclosporine, effect, TRICOR>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The benefits and risks of using TRICOR with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed

<TRICOR, advise, immunosuppressants>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Therefore, fenofibrate should be taken at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption .

<fenofibrate, advise, bile acid binding resin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concomitant administration of fenofibrate (equivalent to 145mg TRICOR) with pravastatin (40 mg) once daily for 10 days has been shown to increase the mean Cmax and AUC values for pravastatin by 36% (range from 69% decrease to 321% increase) and 28% (range from 54% decrease to 128% increase), respectively, and for 3 -hydroxy-iso-pravastatin by 55% (range from 32% decrease to 314% increase) and 39% (range from 24% decrease to 261% increase), respectively in 23 healthy adults.

<fenofibrate, mechanism, pravastatin>, <TRICOR, mechanism, pravastatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concomitant administration of fenofibrate (equivalent to 145 mg TRICOR) with atorvastatin (20 mg) once daily for 10 days resulted in approximately 17% decrease (range from 67% decrease to 44% increase) in atorvastatin AUC values in 22 healthy males.

<fenofibrate, mechanism, atorvastatin>, <TRICOR, mechanism, atorvastatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The daily dose of ENABLEX should not exceed 7.5 mg when coadministered with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin and nefazadone) .

<ENABLEX, advise, ketoconazole>, <ENABLEX, advise, itraconazole>, <ENABLEX, advise, ritonavir>, <ENABLEX, advise, nelfinavir>, <ENABLEX, advise, clarithromycin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Caution should be taken when ENABLEX is used concomitantly with medications that are predominantly metabolized by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine and tricyclic antidepressants (see CLINICAL PHARMACOLOGY).

<ENABLEX, advise, flecainide>, <ENABLEX, advise, thioridazine>, <ENABLEX, advise, tricyclic antidepressants>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

The concomitant use of ENABLEX with other anticholinergic agents may increase the frequency and/or severity of dry mouth, constipation, blurred vision and other anticholinergic pharmacological effects.

<ENABLEX, effect, anticholinergic agents>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Concurrent administration of HEXALEN and antidepressants of the MAO inhibitor class may cause severe orthostatic hypotension.Cimetidine, an inhibitor of microsomal drug metabolism, increased altretamines half-life and toxicity in a rat model.

<HEXALEN, effect, antidepressants of the MAO inhibitor class>, <Cimetidine, mechanism, altretamine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Data from a randomized trial of HEXALEN and cisplatin plus or minus pyridoxine in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity;

<HEXALEN, effect, cisplatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

however, it adversely affected response duration suggesting that pyridoxine should not be administered with HEXALEN and/or cisplatin.1

<pyridoxine, advise, HEXALEN>, <pyridoxine, advise, cisplatin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Special consideration should be given to the administration of ETHYOL in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.

<ETHYOL, advise, antihypertensive medications>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Valproate: Tiagabine causes a slight decrease (about 10%) in steady-state valproate concentrations.

<Tiagabine, mechanism, valproate>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Effects of other Antiepilepsy Drugs (AEDs) on GABITRIL : Carbamazepine: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking carbamazepine with or without other enzyme- inducing AEDs.

<tiagabine, mechanism, carbamazepine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phenytoin: Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenytoin with or without other enzyme- inducing AEDs.

<tiagabine, mechanism, phenytoin>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Phenobarbital (Primidone): Population pharmacokinetic analyses indicate that tiagabine clearance is 60% greater in patients taking phenobarbital (primidone) with or without other enzyme-inducing AEDs.

<tiagabine, mechanism, phenobarbital>, <tiagabine, mechanism, primidone>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Valproate: The addition of tiagabine to patients taking valproate chronically had no effect on tiagabine pharmacokinetics, but valproate significantly decreased tiagabine binding in vitro from 96.3 to 94.8%, which resulted in an increase of approximately 40% in the free tiagabine concentration.

<valproate, mechanism, tiagabine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Because of the possible additive effects of drugs that may depress the nervous system, ethanol or triazolam should be used cautiously in combination with tiagabine.

<ethanol, advise, tiagabine>, <triazolam, advise, tiagabine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Sulfapyridine may interact with any of the following: - Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or

<Sulfapyridine, int, Acetaminophen>, <Sulfapyridine, int, Tylenol>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

- Antidiabetics, oral (diabetes medicine you take by mouth) Use of oral antidiabetics with sulfapyridine may increase the chance of side effects affecting the blood and/or the side effects or oral antidiabetics

<antidiabetics, effect, sulfapyridine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

- Methotrexate (e.g., Mexate) Use of methotrexate with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of methotrexate

<methotrexate, effect, sulfapyridine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

- Methyldopa (e.g., Aldomet) Use of methyldopa with sulfapyridine may increase the chance of side effects affecting the liver and/or the blood

<methyldopa, effect, sulfapyridine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

- Phenytoin (e.g., Dilantin) Use of phenytoin with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of phenytoin

<phenytoin, effect, sulfapyridine>

Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets.

Elevated plasma levels of theophylline have been reported with concomitant use of some quinolones.

<theophylline, mechanism, quinolones>