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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There have been reports of theophylline-related side-effects in patients on concomitant theophylline-quinolone therapy. | <theophylline, effect, quinolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolones have also been shown to interfere with the metabolism of caffeine. | <Quinolones, mechanism, caffeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although this interaction has not been reported with cinoxacin, caution should be exercised when cinoxacin is given concomitantly with caffeine-containing products. | <cinoxacin, advise, caffeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids or sucralfate substantially interfere with the absorption of some quinolones, resulting in low urine levels. | <Antacids, mechanism, quinolones>, <sucralfate, mechanism, quinolones> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Also, concomitant administration of quinolones with products containing iron, multivitamins containing zinc, or Videx (didanosine) chewable/buffered tablets or the pediatric powder for oral solution may result in low urine levels. | <quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, Videx>, <quinolones, mechanism, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolones, including cinoxacin, may enhance the effects of oral anticoagulants, such as warfarin or its derivatives. | <Quinolones, effect, anticoagulants>, <Quinolones, effect, warfarin>, <cinoxacin, effect, anticoagulants>, <cinoxacin, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Seizures have been reported in patients taking another quinolone class antimicrobial and the nonsteroidal anti-inflammatory drug fenbufen concurrently. | <quinolone class antimicrobial, effect, nonsteroidal anti-inflammatory drug>, <quinolone class antimicrobial, effect, fenbufen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Physicians are provided this information to increase awareness of the potential for serious interactions when cinoxacin and certain nonsteroidal anti-inflammatory agents are administered concomitantly. | <cinoxacin, advise, nonsteroidal anti-inflammatory agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Elevated cyclosporine serum levels have been reported with the concomitant use of quinolones and cyclosporine. | <quinolones, mechanism, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of quinolones with antacids containing aluminum, magnesium, or calcium, with sucralfate, with metal cations such as iron, or with multivitamins containing iron or zinc, or with formulations containing divalent and trivalent cations such as VIDEX (didanosine) chewable/buffered tablets or the pediatric powder for oral solution, may substantially interfere with the absorption of quinolones, resulting in systemic concentrations considerably lower than desired. | <quinolones, mechanism, aluminum>, <quinolones, mechanism, magnesium>, <quinolones, mechanism, calcium>, <quinolones, mechanism, sucralfate>, <quinolones, mechanism, iron>, <quinolones, mechanism, multivitamins>, <quinolones, mechanism, iron>, <quinolones, mechanism, zinc>, <quinolones, mechanism, VIDEX>, <quinolones, mechanism, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caffeine Theobromine Grepafloxacin, like other quinolones, may inhibit the metabolism of caffeine and theobromine. | <Grepafloxacin, mechanism, caffeine>, <Grepafloxacin, mechanism, theobromine>, <quinolones, mechanism, caffeine>, <quinolones, mechanism, theobromine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Theophylline: Grepafloxacin is a competitive inhibitor of the metabolism of theophylline. | <Grepafloxacin, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Serum theophylline concentrations increase when grepafloxacin is initiated in a patient maintained on theophylline. | <grepafloxacin, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When initiating a multi-day course of grepafloxacin in a patient maintained on theophylline, the theophylline maintenance dose should be halved for the period of concurrent use of grepafloxacin and monitoring of serum theophylline concentrations should be initiated as a guide to further dosage adjustments. | <theophylline, advise, grepafloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, because some quinolones have been reported to enhance the effects of warfarin or its derivatives, prothrombin time or other suitable anticoagulation test should be monitored closely if a quinolone antimicrobial is administered with warfarin or its derivatives. | <quinolones, effect, warfarin>, <quinolone antimicrobial, advise, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs Metabolized by Cytochrome P450 Enzymes The drug interaction study evaluating the effect of grepafloxacin on theophylline indicates that grepafloxacin inhibits theophylline metabolism, which is mediated by CYP1A2. | <grepafloxacin, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In addition, other quinolones have been reported to decrease the CYP3A4-mediated metabolism of cyclosporine. | <quinolones, mechanism, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nonsteroidal Anti-inflammatory Drugs (NSAIDs): The concomitant administration of a nonsteroidal anti inflammatory drug with a quinolone may increase the risks of CNS stimulation and convulsions. | <nonsteroidal anti inflammatory drug, effect, quinolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. | <quinolones, effect, antidiabetic agent> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concurrent use of Robinul Injection with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants, may intensify the antimuscarinic effects and may result in an increase in anticholinergic side effects. | <Robinul, effect, anticholinergics>, <Robinul, effect, phenothiazines>, <Robinul, effect, antiparkinson drugs>, <Robinul, effect, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of Robinul Injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time. | <Robinul, mechanism, potassium chloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral doses of Antizol (10-20 mg/kg), via alcohol dehydrogenase inhibition, significantly reduced the rate of elimination of ethanol (by approximately 40%) given to healthy volunteers in moderate doses. | <Antizol, mechanism, ethanol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Similarly, ethanol decreased the rate of elimination of Antizol (by approximately 50%) by the same mechanism. | <ethanol, mechanism, Antizol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Reciprocal interactions may occur with concomitant use of Antizol and drugs that increase or inhibit the cytochrome P450 system (e.g., phenytoin, carbamazepine, cimetidine, ketoconazole), though this has not been studied | <Antizol, mechanism, phenytoin>, <Antizol, mechanism, carbamazepine>, <Antizol, mechanism, cimetidine>, <Antizol, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When administered concurrently, the following drugs may interact with beta-adrenergic receptor blocking agents: Anesthetics, general: exaggeration of the hypotension induced by general anesthetics. | <beta-adrenergic receptor blocking agents, int, Anesthetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Elevated plasma levels of theophylline have been reported with concomitant quinolone use. | <theophylline, mechanism, quinolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There have been reports of theophylline-related side effects in patients on concomitant therapy with quinolones and theophylline. | <quinolones, effect, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolones have been shown to interfere with the metabolism of caffeine. | <Quinolones, mechanism, caffeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinolones, including nalidixic acid, may enhance the effects of the oral anticoagulant warfarin or its derivatives. | <Quinolones, effect, warfarin>, <nalidixic acid, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nitrofurantoin interferes with the therapeutic action of nalidixic acid. | <Nitrofurantoin, effect, nalidixic acid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | and Videx , (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the absorption of quinolones, resulting in systemic levels considerably lower than desired. | <Videx, mechanism, quinolones>, <Didanosine, mechanism, quinolones> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Elevated serum levels of cyclosporine have been reported with the concomitant use of some quinolones and cyclosporine. | <quinolones, mechanism, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Metformin: In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. | <cephalexin, mechanism, metformin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. | <cephalexin, mechanism, metformin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin. | <cephalexin, advise, metformin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid. | <cephalexin, mechanism, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be exercised when administering ETOPOPHOS with drugs that are known to inhibit phosphatase activities (e.g., levamisole hydrochloride). | <ETOPOPHOS, advise, levamisole hydrochloride> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | High-dose cyclosporin A resulting in concentrations above 2000 ng/mL administered with oral etoposide has led to an 80% increase in etoposide exposure with a 38% decrease in total body clearance of etoposide compared to etoposide alone. | <cyclosporin A, mechanism, etoposide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diuretics: Patients on diuretics, especially those with intravascular volume depletion, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with fosinopril sodium. | <diuretics, effect, fosinopril sodium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The possibility of hypotensive effects can be minimized by either discontinuing the diuretic or increasing salt intake prior to initiation of treatment with fosinopril sodium. | <diuretic, effect, fosinopril sodium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Potassium Supplements and Potassium-Sparing Diuretics: Fosinopril sodium can attenuate potassium loss caused by thiazide diuretics. | <Fosinopril sodium, effect, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium. | <ACE inhibitors, effect, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids: In a clinical pharmacology study, coadministration of an antacid (aluminum hydroxide, magnesium hydroxide, and simethicone) with fosinopril reduced serum levels and urinary excretion of fosinoprilat as compared with fosinopril administered alone, suggesting that antacids may impair absorption of fosinopril. | <antacid, mechanism, fosinopril>, <aluminum hydroxide, mechanism, fosinopril>, <magnesium hydroxide, mechanism, fosinopril>, <simethicone, mechanism, fosinopril>, <antacids, mechanism, fosinopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drug Interactions: Flupenthixol may interact with some drugs, like Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics - Arecoline - Eproxindine - Ethanol: Flupenthixol and Ethanol cause additive CNS depression - Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants | <Flupenthixol, int, Monoamine oxidase inhibitors>, <Flupenthixol, int, MAOI>, <MAOI, effect, flupenthixol>, <Flupenthixol, effect, Ethanol>, <Flupenthixol, effect, Tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Curariform muscle relaxants (eg, tubocurarine) and other drugs, including ether, succinylcholine, gallamine, decamethonium and sodium citrate, potentiate the neuromuscular blocking effect and should be used with extreme caution in patients being treated with Coly-Mycin M Parenteral. | <Curariform muscle relaxants, effect, Coly-Mycin M>, <tubocurarine, effect, Coly-Mycin M>, <succinylcholine, effect, Coly-Mycin M>, <gallamine, effect, Coly-Mycin M>, <decamethonium, effect, Coly-Mycin M>, <sodium citrate, effect, Coly-Mycin M> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sodium cephalothin may enhance the nephrotoxicity of Coly-Mycin M Parenteral. | <Sodium cephalothin, effect, Coly-Mycin M> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of sodium cephalothin and Coly-Mycin M Parenteral should be avoided. | <sodium cephalothin, advise, Coly-Mycin M> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hypotension - Patients on Diuretic Therapy: Patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with PRINIVIL. | <diuretics, effect, PRINIVIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The possibility of hypotensive effects with PRINIVIL can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with PRINIVIL. | <diuretic, effect, PRINIVIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If it is necessary to continue the diuretic, initiate therapy with PRINIVIL at a dose of 5 mg daily, and provide close medical supervision after the initial dose until blood pressure has stabilized. | <diuretic, advise, PRINIVIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When a diuretic is added to the therapy of a patient receiving PRINIVIL, an additional antihypertensive effect is usually observed. | <diuretic, effect, PRINIVIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Studies with ACE inhibitors in combination with diuretics indicate that the dose of the ACE inhibitor can be reduced when it is given with a diuretic. | <ACE inhibitor, advise, diuretic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with non-steroidal anti-inflammatory drugs, the co-administration of lisinopril may result in a further deterioration of renal function. | <non-steroidal anti-inflammatory drugs, effect, lisinopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors, including lisinopril. | <NSAIDs, effect, ACE inhibitors>, <NSAIDs, effect, lisinopril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors. | <NSAIDs, advise, ACE inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Agents Increasing Serum Potassium: PRINIVIL attenuates potassium loss caused by thiazide-type diuretics. | <PRINIVIL, effect, thiazide-type diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use of PRINIVIL with potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. | <PRINIVIL, effect, potassium-sparing diuretics>, <PRINIVIL, effect, spironolactone>, <PRINIVIL, effect, triamterene>, <PRINIVIL, effect, amiloride>, <PRINIVIL, effect, potassium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. | <lithium, effect, ACE inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor. | <lithium, effect, ACE inhibitor> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that serum lithium levels be monitored frequently if PRINIVIL is administered concomitantly with lithium. | <PRINIVIL, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors. | <butalbital, effect, monoamine oxidase (MAO) inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression. | <Butalbital, effect, narcotic analgesic>, <Butalbital, effect, alcohol>, <Butalbital, effect, anesthetics>, <Butalbital, effect, tranquilizers>, <Butalbital, effect, chlordiazepoxide>, <Butalbital, effect, sedative-hypnotics>, <Butalbital, effect, CNS depressants>, <acetaminophen, effect, narcotic analgesic>, <acetaminophen, effect, alcohol>, <acetaminophen, effect, anesthetics>, <acetaminophen, effect, tranquilizers>, <acetaminophen, effect, chlordiazepoxide>, <acetaminophen, effect, sedative-hypnotics>, <acetaminophen, effect, CNS depressants>, <caffeine, effect, narcotic analgesic>, <caffeine, effect, alcohol>, <caffeine, effect, anesthetics>, <caffeine, effect, tranquilizers>, <caffeine, effect, chlordiazepoxide>, <caffeine, effect, sedative-hypnotics>, <caffeine, effect, CNS depressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | CNS-Active Drugs Ethanol: Sonata 10 mg potentiated the CNS-impairing effects of ethanol 0.75 g/kg on balance testing and reaction time for 1 hour after ethanol administration and on the digit symbol substitution test (DSST), symbol copying test, and the variability component of the divided attention test for 2.5 hours after ethanol administration. | <Sonata, effect, ethanol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Imipramine: Coadministration of single doses of Sonata 20 mg and imipramine 75 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration. | <Sonata, effect, imipramine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thioridazine: Coadministration of single doses of Sonata 20 mg and thioridazine 50 mg produced additive effects on decreased alertness and impaired psychomotor performance for 2 to 4 hours after administration. | <Sonata, effect, thioridazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Promethazine: Coadministration of a single dose of zaleplon and promethazine (10 and 25 mg, respectively) resulted in a 15% decrease in maximal plasma concentrations of zaleplon, but no change in the area under the plasma concentration-time curve. | <zaleplon, mechanism, promethazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Multiple-dose administration of the potent CYP3A4 inducer rifampin (600 mg every 24 hours, q24h, for 14 days), however, reduced zaleplon Cmax and AUC by approximately 80%. | <rifampin, mechanism, zaleplon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of single, oral doses of zaleplon with erythromycin (10 mg and 800 mg, respectively), a strong, selective CYP3A4 inhibitor produced a 34% increase in zaleplons maximal plasma concentrations and a 20% increase in the area under the plasma concentration-time curve. | <zaleplon, mechanism, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon. | <ketoconazole, mechanism, zaleplon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs That Inhibit Both Aldehyde Oxidase and CYP3A4 Cimetidine: Cimetidine inhibits both aldehyde oxidase (in vitro) and CYP3A4 (in vitro and in vivo), the primary and secondary enzymes, respectively, responsible for zaleplon metabolism. | <Cimetidine, mechanism, zaleplon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of Sonata (10 mg) and cimetidine (800 mg) produced an 85% increase in the mean Cmax and AUC of zaleplon. | <Sonata, mechanism, cimetidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A pharmacokinetic study evaluating the administration of a single dose of INSPRA 100 mg with ketoconazole 200 mg BID, a potent inhibitor of the CYP3A4 pathway, showed a 1.7-fold increase in Cmax of eplerenone and a 5.4-fold increase in AUC of eplerenone. | <INSPRA, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of eplerenone with other CYP3A4 inhibitors (e.g., erythromycin 500 mg BID, verapamil 240 mg QD, saquinavir 1200 mg TID, fluconazole 200 mg QD) resulted in increases in Cmax of eplerenone ranging from 1.4- to 1.6- fold and AUC from 2.0- to 2.9- fold. | <eplerenone, mechanism, erythromycin>, <eplerenone, mechanism, verapamil>, <eplerenone, mechanism, saquinavir>, <eplerenone, mechanism, fluconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | ACE Inhibitors and Angiotensin II Receptor Antagonists (Hypertension)- In clinical studies of patients with hypertension, the addition of INSPRA 50 to 100 mg to ACE inhibitors and angiotensin II receptor antagonists increased mean serum potassium slightly (about 0.09-0.13 mEq/L). | <INSPRA, effect, ACE inhibitors>, <INSPRA, effect, angiotensin II receptor antagonists> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in diabetics with microalbuminuria INSPRA 200 mg combined with the ACE inhibitor enalapril 10 mg increased the frequency of hyperkalemia (serum potassium 5.5 mEq/L) from 17% on enalapril alone to 38%. | <INSPRA, effect, enalapril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Serum lithium levels should be monitored frequently if INSPRA is administered concomitantly with lithium. | <INSPRA, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The administration of other potassium-sparing antihypertensives with NSAIDs has been shown to reduce the antihypertensive effect in some patients and result in severe hyperkalemia in patients with impaired renal function. | <potassium-sparing antihypertensives, effect, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, when INSPRA and NSAIDs are used concomitantly, patients should be observed to determine whether the desired effect on blood pressure is obtained. | <INSPRA, advise, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aminoglutethimide: Aminoglutethimide may diminish adrenal suppression by corticosteroids. | <Aminoglutethimide, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. | <corticosteroids, advise, amphotericin B>, <corticosteroids, advise, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In addition, there have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure. | <amphotericin B, effect, hydrocortisone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance. | <Macrolide antibiotics, mechanism, corticosteroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. | <anticholinesterase agents, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy. | <anticholinesterase agents, advise, corticosteroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticoagulants, oral: Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports. | <corticosteroids, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. | <corticosteroids, effect, antidiabetic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cholestyramine: Cholestyramine may increase the clearance of corticosteroids. | <Cholestyramine, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. | <cyclosporine, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ephedrine: Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring an increase in corticosteroid dosage. | <Ephedrine, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect. | <Estrogens, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased. | <barbiturates, mechanism, corticosteroids>, <phenytoin, mechanism, corticosteroids>, <carbamazepine, mechanism, corticosteroids>, <rifampin, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drugs which inhibit CYP 3A4 (e.g., ketoconazole, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids. | <ketoconazole, mechanism, corticosteroids>, <macrolide antibiotics, mechanism, corticosteroids>, <erythromycin, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects. | <Ketoconazole, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal. | <ketoconazole, effect, corticosteroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nonsteroidal anti-inflammatory agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal antiinflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. | <aspirin, effect, corticosteroids>, <nonsteroidal antiinflammatory agents, effect, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. | <Aspirin, advise, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The clearance of salicylates may be increased with concurrent use of corticosteroids. | <salicylates, mechanism, corticosteroids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin: In post-marketing experience, there have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administration, leading to alterations in seizure control. | <phenytoin, mechanism, dexamethasone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vaccines: Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response. | <corticosteroid, effect, live vaccines>, <corticosteroid, effect, inactivated vaccines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. | <Corticosteroids, effect, live attenuated vaccines> |