instruction
stringclasses 1
value | input
stringlengths 42
1.01k
| output
stringlengths 16
2.12k
|
|---|---|---|
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorpromazine: Chlorpromazine blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning. | <Chlorpromazine, effect, amphetamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethosuximide: Amphetamines may delay intestinal absorption of ethosuximide. | <Amphetamines, mechanism, ethosuximide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Haloperidol: Haloperidol blocks dopamine and norepinephrine reuptake, thus inhibiting the central stimulant effects of amphetamines. | <Haloperidol, effect, amphetamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium carbonate: The stimulatory effects of amphetamines may be inhibited by lithium carbonate. | <amphetamines, effect, lithium carbonate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Meperidine: Amphetamines potentiate the analgesic effect of meperidine. | <Amphetamines, effect, meperidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methenamine therapy: Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy. | <amphetamines, mechanism, acidifying agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Norepinephrine: Amphetamines enhance the adrenergic effect of norepinephrine. | <Amphetamines, effect, norepinephrine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenobarbital: Amphetamines may delay intestinal absorption of phenobarbital; | <Amphetamines, mechanism, phenobarbital> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin: Amphetamines may delay intestinal absorption of phenytoin; | <Amphetamines, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Propoxyphene: In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur. | <propoxyphene, effect, amphetamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Veratrum alkaloids: Amphetamines inhibit the hypotensive effect of veratrum alkaloids. | <Amphetamines, effect, veratrum alkaloids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone. | <erythromycin, mechanism, loratadine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tablet If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the effect of clonidine may be reduced, thus necessitating an increase in dosage. | <clonidine hydrochloride, effect, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Clonidine hydrochloride may enhance the CNS-depressive effects of alcohol, barbiturates or other sedatives. | <Clonidine hydrochloride, effect, alcohol>, <Clonidine hydrochloride, effect, barbiturates>, <Clonidine hydrochloride, effect, sedatives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats Epidural Injection Clonidine may potentiate the CNS-depressive effect of alcohol, barbiturates or other sedating drugs. | <Amitriptyline, effect, clonidine>, <Clonidine, effect, alcohol>, <Clonidine, effect, barbiturates>, <Clonidine, effect, sedating drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Narcotic analgesics may potentiate the hypotensive effects of clonidine. | <Narcotic analgesics, effect, clonidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tricyclic antidepressants may antagonize the hypotensive effects of clonidine. | <Tricyclic antidepressants, effect, clonidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Beta blockers may exacerbate the hypertensive response seen with clonidine withdrawl. | <Beta blockers, effect, clonidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.) | <clonidine, advise, digitalis>, <clonidine, advise, calcium channel blockers>, <clonidine, advise, beta-blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There is one reported case of a patient with acute delirium associated with the simultaneous use of fluphenazine and oral clonidine. | <fluphenazine, effect, clonidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Epidural clonidine may prolong the duration of pharmacologic effects of epidural local anesthetics, including both sensory and motor blockade. | <clonidine, effect, anesthetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In addition, several AED s that are cytochrome P450 inducers can decrease plasma concentrations of oxcarbazepine and MHD. | <AED, mechanism, oxcarbazepine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | 1- nc denotes a mean change of less than 10% 2- Pediatrics 3- Mean increase in adults at high Trileptal doses In vivo, the plasma levels of phenytoin increased by up to 40%, when Trileptal was given at doses above 1200 mg/day. | <phenytoin, mechanism, Trileptal> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, when using doses of Trileptal greater than 1200 mg/day during adjunctive therapy, a decrease in the dose of phenytoin may be required. | <Trileptal, advise, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The increase of phenobarbital level, however, is small (15%) when given with Trileptal. | <phenobarbital, mechanism, Trileptal> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hormonal contraceptives Co-administration of Trileptal with an oral contraceptive has been shown to influence the plasma concentrations of the two hormonal components, ethinylestradiol (EE) and levonorgestrel (LNG). | <Trileptal, mechanism, contraceptive> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, concurrent use of Trileptal with hormonal contraceptives may render these contraceptives less effective. | <Trileptal, effect, hormonal contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Calcium Antagonists: After repeated co-administration of Trileptal, the AUC of felodipine was lowered by 28% [90% CI: 20-33]. | <Trileptal, mechanism, felodipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with dihydrotachysterol may cause hypercalcemia. | <thiazide diuretics, effect, dihydrotachysterol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Lofexidine may enhance the CNS depressive effects of alcohol, barbiturates and other sedatives | <Lofexidine, effect, alcohol>, <Lofexidine, effect, barbiturates>, <Lofexidine, effect, sedatives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Lofexidine may enhance the effects of anti-hypertensive drug therapy | <Lofexidine, effect, anti-hypertensive drug> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | - Concomitant use of tricyclic antidepressants may reduce the efficacy of lofexidine. | <tricyclic antidepressants, effect, lofexidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although the clinical significance is not known, it is not recommended that cefditoren pivoxil be taken concomitantly with antacids. | <cefditoren pivoxil, advise, antacids> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | H2-Receptor Antagonists: Co-administration of a single dose of intravenously administered famotidine (20 mg) reduced the oral absorption of a single 400 mg dose of cefditoren pivoxil administered following a meal, as evidenced by a 27% decrease in mean Cmax and a 22% decrease in mean AUC. | <famotidine, mechanism, cefditoren pivoxil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: As with other b-lactam antibiotics, co-administration of probenecid with cefditoren pivoxil resulted in an increase in the plasma exposure of cefditoren, with a 49% increase in mean Cmax, a 122% increase in mean AUC, and a 53% increase in half-life. | <b-lactam antibiotics, mechanism, cefditoren pivoxil>, <probenecid, mechanism, cefditoren pivoxil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected than when atropine is used alone because pralidoxime may potentiate the effect of atropine. | <atropine, effect, pralidoxime>, <pralidoxime, effect, atropine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The following precautions should be kept in mind in the treatment of anticholinesterase poisoning although they do not bear directly on the use of atropine and pralidoxime. | <atropine, advise, pralidoxime> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since barbiturates are potentiated by the anticholinesterases, they should be used cautiously in the treatment of convulsions. | <barbiturates, advise, anticholinesterases> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ocupress should be used with caution in patients who are receiving a beta-adrenergic blocking agent orally because of the potential for additive effects on systemic beta-blockade. | <Ocupress, advise, beta-adrenergic blocking agent> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Close observation of the patient is recommended when a beta-blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may produce vertigo, syncope, or postural hypotension. | <beta-blocker, advise, reserpine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although specific studies have not been performed, coadministration with drugs that are mainly metabolized by CYP3A4 (eg, calcium channel blockers, dapsone, disopyramide, quinine, amiodarone, quinidine, warfarin, tacrolimus, cyclosporine, ergot derivatives, pimozide, carbamazepine, fentanyl, alfentanyl, alprazolam, and triazolam) may have elevated plasma concentrations when coadministered with saquinavir; | <calcium channel blockers, mechanism, saquinavir>, <dapsone, mechanism, saquinavir>, <disopyramide, mechanism, saquinavir>, <quinine, mechanism, saquinavir>, <amiodarone, mechanism, saquinavir>, <quinidine, mechanism, saquinavir>, <warfarin, mechanism, saquinavir>, <tacrolimus, mechanism, saquinavir>, <cyclosporine, mechanism, saquinavir>, <ergot derivatives, mechanism, saquinavir>, <pimozide, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir>, <fentanyl, mechanism, saquinavir>, <alfentanyl, mechanism, saquinavir>, <alprazolam, mechanism, saquinavir>, <triazolam, mechanism, saquinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since INVIRASE is coadministered with ritonavir, the ritonavir label should be reviewed for additional drugs that should not be coadministered. | <INVIRASE, advise, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration with compounds that are potent inducers of CYP3A4 (eg, phenobarbital, phenytoin, dexamethasone, carbamazepine) may result in decreased plasma levels of saquinavir. | <phenobarbital, mechanism, saquinavir>, <phenytoin, mechanism, saquinavir>, <dexamethasone, mechanism, saquinavir>, <carbamazepine, mechanism, saquinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro mixing of an aminoglycoside with beta-lactamtype antibiotics (penicillins or cephalosporins) may result in a significant mutual inactivation. | <aminoglycoside, effect, antibiotics>, <aminoglycoside, effect, penicillins>, <aminoglycoside, effect, cephalosporins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Even when an aminoglycoside and a penicillin-type drug are administered separately by different routes, a reduction in aminoglycoside serum half-life or serum levels has been reported in patients with impaired renal function and in some patients with normal renal function. | <aminoglycoside, mechanism, penicillin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethanol:Clinical evidence has shown that etretinate can be formed with concurrent ingestion of acitretin and ethanol. | <acitretin, mechanism, ethanol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Glibenclamide: In a study of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose lowering effect of glibenclamide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects. | <acitretin, effect, glibenclamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, it has been established that acitretin interferes with the contraceptive effect of microdosed progestin minipill preparations. | <acitretin, effect, progestin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Microdosed minipill progestin preparations are not recommended for use with Soriatane. | <progestin, advise, Soriatane> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methotrexate: An increased risk of hepatitis has been reported to result from combined use of methotrexate and etretinate. | <methotrexate, effect, etretinate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Consequently, the combination of methotrexate with acitretin is also contraindicated. | <methotrexate, advise, acitretin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin: If acitretin is given concurrently with phenytoin, the protein binding of phenytoin may be reduced. | <acitretin, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tetracyclines: Since both acitretin and tetracyclines can cause increased intracranial pressure, their combined use is contraindicated. | <acitretin, effect, tetracyclines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vitamin A and oral retinoids: Concomitant administration of vitamin A and/or other oral retinoids with acitretin must be avoided because of the risk of hypervitaminosis A. | <vitamin A, advise, acitretin>, <retinoids, advise, acitretin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Use of Cerubidine in a patient who has previously received doxorubicin increases the risk of cardiotoxicity. | <Cerubidine, effect, doxorubicin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cerubidine should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or Cerubidine. | <Cerubidine, advise, doxorubicin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclophosphamide used concurrently with Cerubidine may also result in increased cardiotoxicity. | <Cyclophosphamide, effect, Cerubidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, the concomitant use of Argatroban and warfarin (5-7.5 mg initial oral dose followed by 2.5-6 mg/day orally for 6-10 days) results in prolongation of the prothrombin time (PT) and International Normalized Ratio (INR). | <Argatroban, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration: Concomitant use of Argatroban with antiplatelet agents, thrombolytics, and other anticoagulants may increase the risk of bleeding. | <Argatroban, effect, antiplatelet agents>, <Argatroban, effect, thrombolytics>, <Argatroban, effect, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | ACE inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors. | <NSAIDs, effect, Angiotensin Converting Enzyme (ACE) inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients with mild to moderate hypertension, administration of 25 mg daily of VIOXX with the ACE inhibitor benazepril, 10 to 40 mg for 4 weeks, was associated with an average increase in mean arterial pressure of about 3 mm Hg compared to ACE inhibitor alone. | <VIOXX, effect, benazepril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This interaction should be given consideration in patients taking VIOXX concomitantly with ACE inhibitors. | <VIOXX, advise, ACE inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aspirin: Concomitant administration of low-dose aspirin with VIOXX may result in an increased rate of GI ulceration or other complications, compared to use of VIOXX alone. | <aspirin, effect, VIOXX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: Co-administration with high doses of cimetidine [800 mg twice daily] increased the Cmax of rofecoxib by 21%, the AUC0-120hr by 23% and the t1/2 by 15%. | <cimetidine, mechanism, rofecoxib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Furosemide: Clinical studies, as well as post-marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. | <NSAIDs, effect, furosemide>, <NSAIDs, effect, thiazides> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. | <NSAIDs, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thus, when VIOXX and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. | <VIOXX, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | At higher than recommended doses, VIOXX 75 mg administered once daily for 10 days increased plasma concentrations by 23% as measured by AUC0-24hr in patients receiving methotrexate 7.5 to 15 mg/week for rheumatoid arthritis. | <VIOXX, mechanism, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | At 24 hours postdose, a similar proportion of patients treated with methotrexate alone (94%) and subsequently treated with methotrexate co-administered with 75 mg of rofecoxib (88%) had methotrexate plasma concentrations below the measurable limit (5 ng/mL). | <methotrexate, mechanism, rofecoxib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Standard monitoring of methotrexate-related toxicity should be continued if VIOXX and methotrexate are administered concomitantly. | <VIOXX, advise, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin: Co-administration of VIOXX with rifampin 600 mg daily, a potent inducer of hepatic metabolism, produced an approximate 50% decrease in rofecoxib plasma concentrations. | <VIOXX, mechanism, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Theophylline VIOXX 12.5, 25, and 50 mg administered once daily for 7 days increased plasma theophylline concentrations (AUC(0- )) by 38 to 60% in healthy subjects administered a single 300-mg dose of theophylline. | <VIOXX, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Adequate monitoring of theophylline plasma concentrations should be considered when therapy with VIOXX is initiated or changed in patients receiving theophylline. | <VIOXX, advise, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin: Anticoagulant activity should be monitored, particularly in the first few days after initiating or changing VIOXX therapy in patients receiving warfarin or similar agents, since these patients are at an increased risk of bleeding complications. | <VIOXX, advise, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In single and multiple dose studies in healthy subjects receiving both warfarin and rofecoxib, prothrombin time (measured as INR) was increased by approximately 8% to 11%. | <warfarin, effect, rofecoxib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In post-marketing experience, bleeding events have been reported, predominantly in the elderly, in association with increases in prothrombin time in patients receiving VIOXX concurrently with warfarin. | <VIOXX, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | DOSTINEX should not be administered concurrently with D2-antagonists, such as phenothiazines, butyrophenones, thioxanthines, or metoclopramide. | <DOSTINEX, advise, phenothiazines>, <DOSTINEX, advise, butyrophenones>, <DOSTINEX, advise, thioxanthines>, <DOSTINEX, advise, metoclopramide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When lansoprazole was administered concomitantly with theophylline (CYP1A2, CYP3A), a minor increase (10%) in the clearance of theophylline was seen. | <lansoprazole, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nonetheless, individual patients may require additional titration of their theophylline dosage when lansoprazole is started or stopped to ensure clinically effective blood levels. | <theophylline, advise, lansoprazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a single-dose crossover study examining lansoprazole 30 mg and omeprazole 20 mg each administered alone and concomitantly with sucralfate 1 gram, absorption of the proton pump inhibitors was delayed and their bioavailability was reduced by 17% and 16%, respectively, when administered concomitantly with sucralfate. | <proton pump inhibitors, mechanism, sucralfate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, proton pump inhibitors should be taken at least 30 minutes prior to sucralfate. | <proton pump inhibitors, advise, sucralfate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, it is theoretically possible that lansoprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g. ketoconazole, ampicillin esters, iron salts, digoxin). | <lansoprazole, mechanism, ketoconazole>, <lansoprazole, mechanism, ampicillin>, <lansoprazole, mechanism, iron>, <lansoprazole, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Considerable caution should be exercised if PEGANONE is administered concurrently with Phenurone (phenacemide) since paranoid symptoms have been reported during therapy with this combination. | <PEGANONE, advise, Phenurone>, <PEGANONE, advise, phenacemide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A two-way interaction between the hydantoin antiepileptic, phenytoin, and the coumarin anticoagulants has been suggested. | <hydantoin antiepileptic, int, phenytoin>, <hydantoin antiepileptic, int, coumarin anticoagulant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Presumably, phenytoin acts as a stimulator of coumarin metabolism and has been reported to cause decreased serum levels of the coumarin anticoagulants and increased prothrombin-proconvertin concentrations. | <phenytoin, mechanism, coumarin>, <phenytoin, mechanism, coumarin anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Conversely, the coumarin anticoagulants have been reported to increase the serum levels and prolong the serum half-life of phenytoin by inhibiting its metabolism. | <coumarin anticoagulants, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution is therefore advised when administering PEGANONE to patients receiving coumarin anticoagulants. | <PEGANONE, advise, coumarin anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients on warfarin-type anticoagulant therapy may require dosage adjustment of the anticoagulant during and after griseofulvin therapy. | <warfarin-type anticoagulant, advise, griseofulvin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of barbiturates usually depresses griseofulvin activity and may necessitate raising the dosage. | <barbiturates, effect, griseofulvin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant administration of griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthrough bleeding. | <griseofulvin, effect, contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid : Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine). | <Probenecid, mechanism, acetaminophen>, <Probenecid, mechanism, acyclovir>, <Probenecid, mechanism, angiotensin-converting enzyme inhibitors>, <Probenecid, mechanism, aminosalicylic acid>, <Probenecid, mechanism, barbiturates>, <Probenecid, mechanism, benzodiazepines>, <Probenecid, mechanism, bumetanide>, <Probenecid, mechanism, clofibrate>, <Probenecid, mechanism, methotrexate>, <Probenecid, mechanism, famotidine>, <Probenecid, mechanism, furosemide>, <Probenecid, mechanism, nonsteroidal anti-inflammatory>, <Probenecid, mechanism, theophylline>, <Probenecid, mechanism, zidovudine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Zidovudine should either be temporarily discontinued or decreased by 50% when coadministered with probenecid on the day of VISTIDE infusion. | <Zidovudine, advise, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nephrotoxic agents : Concomitant administration of VISTIDE and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and non-steroidal anti-inflammatory agents] is contraindicated. | <VISTIDE, advise, aminoglycosides>, <VISTIDE, advise, tobramycin>, <VISTIDE, advise, gentamicin>, <VISTIDE, advise, amikacin>, <VISTIDE, advise, amphotericin B>, <VISTIDE, advise, foscarnet>, <VISTIDE, advise, pentamidine>, <VISTIDE, advise, vancomycin>, <VISTIDE, advise, non-steroidal anti-inflammatory agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, interactions may be expected, and UROXATRAL should NOT be used in combination with other alpha-blockers. | <UROXATRAL, advise, alpha-blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dimenhydrinate may decrease emetic response to apomorphine. | <Dimenhydrinate, effect, apomorphine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin. | <Anticoagulants, effect, ardeparin>, <platelet aggregation inhibitors, effect, ardeparin>, <nonsteroidal anti-inflammatory drugs, effect, ardeparin>, <NSAIDs, effect, ardeparin>, <aspirin, effect, ardeparin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Interactions for vitamin D analogues (Vitamin D2, Vitamin D3, Calcitriol, and Calcidiol): Cholestyramine: Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; | <Cholestyramine, mechanism, fat soluble vitamins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenytoin/Phenobarbital: The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism. | <phenytoin, mechanism, calcitriol>, <phenobarbital, mechanism, calcitriol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. | <thiazides, effect, vitamin D> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digitalis: Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias. | <Vitamin D, advise, digitalis> |