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This prospective trial included 21 patients who were randomly assigned to an effect group ( Group ( DESFLURANE ) ; n = 14 ) or a control group ( Group ( STANDARD-PROPOFOL ) ; n = 7 ) . | METHODS |
The aim of this study was to establish whether using nanocrystalline silver dressings , as an adjunct to the initial debridement , would positively affect wound microbiology and wound healing compared to standard plain gauze dressings . | BACKGROUND |
Midazolam spray can be effectively used through the buccal mucosa in children who give poor compliance with the intranasal administration . | CONCLUSIONS |
This study aimed to evaluate the effect of qigong on prehypertension and mild hypertension and to calculate a sample size for a subsequent randomized , clinical trial ( RCT ) . | OBJECTIVE |
The established three month individualised course of occupational therapy targeting stroke related disabilities did not have an impact on measures of functional activity , mobility , mood , or health related quality of life , at all observational time points . | CONCLUSIONS |
The most common cariprazine-related ( 10 % and twice placebo ) treatment emergent adverse events ( TEAEs ) were akathisia , extrapyramidal disorder , tremor , dyspepsia , and vomiting . | RESULTS |
The clinical cutoff date for the final analysis was Jan 15 , 2014 ( with 611 deaths ) . | RESULTS |
The comparison of influenza vaccination data from vaccination certificates to the remembered data from a self-completed questionnaire showed an agreement of data in 46 % ( 84/184 ) of cases ( Kappa = 0.48 ) . | RESULTS |
Many cases may be preventable because regular participation in physical , mental and social leisure activities during middle age is associated with up to 47 % dementia risk reduction . | BACKGROUND |
The median ( interquartile range ) growth velocity was 17.4 ( 16.3-18 .6 ) g kg day in the intervention group and 13.8 ( 13.2-15 .5 ) g kg day in the control group ( P < 0.001 ) . | RESULTS |
Extracranial bleeding occurred in 32 patients ( 6.3 % ) in the tenecteplase group and 6 patients ( 1.2 % ) in the placebo group ( P < 0.001 ) . | RESULTS |
The EUROMAX trial will test whether bivalirudin started in the ambulance and continued for 4 hours after primary PCI improves clinical outcomes compared with guideline-recommended standard-of-care heparin-based regimens , and will also provide information on the combination of bivalirudin with prasugrel or ticagrelor . | CONCLUSIONS |
The number of confirmed hypoglycaemic events per patient year was 18 for IDegLira , 02 for liraglutide , and 26 for insulin degludec . | RESULTS |
The maximal mean concentration ( 1671 367 ng/g ) was found in NT after consumption of PE-1 and the lowest concentration ( 42.4 10.2 ng/g ) in MT with PE-2 . | RESULTS |
Sixty-eight subjects were included in final analyses . | METHODS |
Secondary outcomes measured were hospitalization rate , proportion of admitted patients discharged at 23 hours , and ED and inpatient length of stay . | METHODS |
In European ancestry subjects , the IL1RN variant rs315952C is preferentially transcribed and associated with increased evoked plasma IL1RA and with improved survival from septic shock . | CONCLUSIONS |
The lack of significant differences between the placebo and VES groups , except the satisfaction domain , puts into question the effectiveness of electrical stimulation as a monotherapy in treating primary FSD without pelvic floor disorder . | CONCLUSIONS |
Secondary outcome measures include differences in withdrawal , time to first lapse and prolonged abstinence at 4 weeks post-quit , which will be biochemically validated at each clinic visit . | METHODS |
The purpose of the Examination of Mechanisms ( E-MECHANIC ) of Exercise-Induced Weight Compensation trial is to examine whether increased energy intake and/or reduced spontaneous activity or energy expenditure ( outside of structured exercise ) account for the less than expected , exercise-associated weight loss . | BACKGROUND |
Eight-five percent of enrolled children were tested ( control = 210 , intervention = 216 ) . | RESULTS |
Trauma-exposed patients are screened for increased PTSD risk with questionnaires assessing peri-traumatic distress and acute PTSD symptoms within 7 days after trauma . | METHODS |
The median time to first SBM was significantly shorter with lubiprostone vs. placebo ( 23.5 vs. 37.7 h , respectively ; P = 0.004 ) . | RESULTS |
The mean ( SD ) PIPP during procedure in Group I were 15.5 2.06 and 14 2.4 at first and second screening ( p = 0.259 ) . | RESULTS |
Serum 25 ( OH ) D concentrations increased ( P 0.005 ) and decreased ( P 0.002 ) in vitamin D and placebo groups , respectively , and were of similar magnitudes in subjects with calcium intakes < 700 mg/d ( and even < 550 mg/d ) compared with > 1000 mg/d . | RESULTS |
Thirty-four partially edentate patients randomly received at least one NobelActive implant ( Nobel Biocare , Gteborg , Sweden ) with back-tapered collar , internal conical connection and platform shifting design , and one NobelSpeedy implant ( Nobel Biocare ) with external hexagon and flat-to-flat implant-abutment interface according to a split-mouth design . | METHODS |
Patients undergoing cardiac surgery were randomized to metoprolol , carvedilol , or carvedilol plus NAC . | METHODS |
The sport-for-development league in this study had no impact on fitness and a negative effect on the mental health of participating boys . | CONCLUSIONS |
Heart rate ( HR ) plays an important role in the assessment of stress during therapeutic hypothermia ( TH ) for neonatal encephalopathy ; we aimed to quantify the effect on HR of endotracheal ( ET ) intubation and drugs given to facilitate it . | OBJECTIVE |
Demographic data , forced expiratory volume at 1 s ( FEV1 ) , additional disease , hemodynamic parameters , respiratory rate , APACHE II score , peripheral O2 saturation ( SpO2 ) , arterial blood gases ( ABG ) , patient tolerance scale ( PTS ) score , and fraction of inspired oxygen ( FiG2 ) were recorded . | METHODS |
The study Simultaneously Targeting Obesity and Pain ( STOP ) is a prospective , pragmatic , randomized controlled trial that aims to determine whether overweight/obese individuals with chronic pain who are randomized to receive an integrated treatment Simultaneously Targeting Obesity and Pain ( STOP ) will show more weight loss and greater reduction in pain intensity over a 6-month period and greater maintenance at 12months than those who receive standard care behavioral weight loss or standard care behavioral pain management . | BACKGROUND |
Treatment with oral propranolol vs prednisolone ( 2.0 mg/kg/d ) until halted owing to toxic effects or clinical response . | METHODS |
Exit rates for ESL 1,600 and 1,200 mg QD were superior to the historical control ; the difference in exit rates between doses was not statistically significant . | CONCLUSIONS |
Sixty-one patients with lumbar canal stenosis ( 50-75 years ; canal area < 100mm2 at L3/L4 , L4/L5 , and/or L5/S1on magnetic resonance imaging ; and claudication within 100m were electronically randomized to an oral corticoid group ( n = 31 ) or a placebo group ( n = 30 ) . | RESULTS |
Posttherapy Ki67 decreased by 3.4 % in the 4-OHT and 5.1 % in the oral-T group ( P 0.03 in both , between-group P = 0.99 ) . | RESULTS |
In hyper-responsive individuals , airway responsiveness increased 42 % following DE compared with FA ( p = 0.03 ) and this increase was abrogated with anti-oxidant supplementation ( diesel exhaust with N-acetylcysteine vs. filtered air with placebo , p = 0.85 ) . | RESULTS |
Sustained ROSC ( emergency department admittance ) , 24h survival and hospital discharge ( unknown for 12 cases ) for iA-CPR compared to M-CPR were 600 ( 28.6 % ) vs. 689 ( 32.3 % ) , 456 ( 21.8 % ) vs. 532 ( 25.0 % ) , 196 ( 9.4 % ) vs. 233 ( 11.0 % ) patients , respectively . | RESULTS |
A late diagnosis precludes curative surgical resection . | BACKGROUND |
The CD34 + cell functions as a central signaling cell to mesenchymal stem cells and osteoprogenitor cells in bone regeneration . | CONCLUSIONS |
Patients who experienced syncope post pacemaker implant had higher mortality compared with patients who did not ( adjusted HR 1.6 , 95 % CI 1.3 to 2.1 , p < 0.001 ) . | RESULTS |
There were no differences between two groups in cyanosis and adverse events . | RESULTS |
Related data were analyzed statistically with t-test and rank sum test . | METHODS |
We examined 5 % of Medicare fee-for-service beneficiaries with heart failure in 2007-2009 . | METHODS |
What is not known , however , is how these factors work together to affect smoking outcomes . | BACKGROUND |
VRS at rest and cough were lower in the TEA group compared with the TAP group at 1 , 6 , 12 , 18 , 24 , 36 and 48 h ( p < 0.001 ) . | RESULTS |
CL and HC interventions occurred for 5 to 10 min before physician entry . | METHODS |
In 375 subjects , serotype-specific responses were measured by 22F-inhibition ELISA and opsonophagocytic killing assays ( OPA ) one month after vaccination . | METHODS |
This trial is registered with ClinicalTrials.gov , number NCT01647269 . | METHODS |
Patients with chronic lumbar pain underwent a sham blockade ( with a saline injection ) and then a controlled medial branch block . | METHODS |
In the subsequent extension study , patients continued with unchanged medication for another 12 months . | METHODS |
The primary outcome was the change in left ventricular mass index ( LVMI ) from baseline to 12 months . | METHODS |
The angle of backrest inclination in sitting ( 675 ) was greater than gained with semi-recumbent positioning ( 505 , p < 0.001 ) . | RESULTS |
The block of the musculocutaneous nerve in the TI group was faster and more successful than in the SI group , at all time points ( all P < 0.026 ) . | RESULTS |
No therapy directed against diabetes has been shown to unequivocally reduce the excess risk of cardiovascular complications . | OBJECTIVE |
The optimal exercise programme has not been identified , and the potential adverse effects of exercise on these patients warrant consideration . | OBJECTIVE |
In PILLAR , duration of PR treatment in the simeprevir/PR groups was determined using response-guided therapy ( RGT ) criteria . | METHODS |
Belatacept-treated patients tended to experience less side effects compared with cyclosporine-treated patients , except for dry skin . | RESULTS |
A regimen of TAC-MR once daily can be considered as an effective and safe alternative formulation of tacrolimus in stable renal transplant patients . | CONCLUSIONS |
In the subanalysis , participants had fewer unplanned hospital admissions and lower associated costs ; higher prescription drug costs ; higher odds of long-term care service use ; higher drug/alcohol treatment costs ; and lower odds of homelessness . | RESULTS |
Patients who underwent vitreoretinal surgery were randomized into 3 groups based on the peribulbar injection they received : lidocaine , bupivacaine , or a combination of lidocaine and bupivacaine . | METHODS |
We hypothesized that 3 modes of aerobic , resistance , and combination exercises have differential effects on the flow-mediated dilation ( FMD ) , carotid-femoral pulse wave velocity ( PWV ) , and carotid intima-media thickness ( IMT ) as well as cardiometabolic profile in weight management . | BACKGROUND |
Adherence , calculated as a proportion of weekly submitted self-measurements , was close to 90 % . | RESULTS |
To test the efficacy of meaning-centered group psychotherapy ( MCGP ) to reduce psychological distress and improve spiritual well-being in patients with advanced or terminal cancer . | OBJECTIVE |
Alirocumab , a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 ( PCSK9 ) , has been shown to reduce low-density lipoprotein ( LDL ) cholesterol levels in patients who are receiving statin therapy . | BACKGROUND |
Early enteral fat supplementation and fish oil ( FO ) stimulates post-resection intestinal adaptation in rats and increases fat absorption in premature infants with bowel resection and an enterostomy . | BACKGROUND |
There are significant practice variation and uncertainty as to the optimal surgical approach for treating CSM . | BACKGROUND |
A trend toward improved OS with decitabine was observed at fixed time points over 2 years . | RESULTS |
Twenty-eight ( 3.4 % ) developed severe haematoma . | RESULTS |
Studies 1 and 3 assessed fed - and fasted-state pharmacokinetics . | METHODS |
JIA flare occurred in 48.1 % of patients on placebo versus 25.6 % continuing tocilizumab ( difference in means adjusted for stratification : -0.21 ; 95 % CI -0.35 to -0.08 ; p = 0.0024 ) . | RESULTS |
Participation was higher in women than in men , especially among women aged 50-59 years ( 25.91 % for colonoscopy and 35.81 % for FIT ) . | RESULTS |
To evaluate the efficacy and safety of sarilumab in combination with methotrexate ( MTX ) for the treatment of rheumatoid arthritis ( RA ) . | OBJECTIVE |
Over a period of 78 weeks , alirocumab , when added to statin therapy at the maximum tolerated dose , significantly reduced LDL cholesterol levels . | CONCLUSIONS |
The 30-day mortality rate was 0.9 % . | RESULTS |
Non-inferiority of patient-driven versus investigator-driven titration with regard to change from baseline to end-of-treatment HbA1c could not be confirmed . | CONCLUSIONS |
Development of new skin cancers . | METHODS |
In a health risk appraisal , all respondents ( N = 5055 ) received feedback on their lifestyle behaviors that indicated whether they complied with the Dutch guidelines for physical activity , vegetable consumption , fruit consumption , alcohol intake , and smoking . | METHODS |
The intervention development was guided by the Intervention Mapping protocol , ensuring a theory-informed and evidence-based intervention . | METHODS |
Four radiotherapy teams were randomly assigned to a training program or a waiting list . | METHODS |
Overall survival was the primary endpoint ; all analyses were by intention to treat . | METHODS |
Fifty percent of pregnancies in the United States are unintended despite numerous contraceptive methods available to women . | OBJECTIVE |
In the multicenter Platelet Dose ( `` PLADO '' ) study , pediatric and adult hematology-oncology patients with hypoproliferative thrombocytopenia were randomized to receive low-dose ( LD ) , medium-dose ( MD ) , or high-dose ( HD ) PLT prophylaxis for a pretransfusion PLT count of not more than 1010 ( 9 ) / L. All PLT units ( apheresis or WBD ) were leukoreduced . | METHODS |
Fifteen years after conversion to a CNI free regimen , there was no benefit regarding graft and patient survival or regarding prevalence of or death by comorbidities . | CONCLUSIONS |
Based on regular treatment including blood pressure and sugar control , EA and rehabilitation therapy were given in three groups . | METHODS |
These data support the usefulness of LNZ continuous infusion , combined with therapeutic drug monitoring ( TDM ) , in selected critically ill populations . | CONCLUSIONS |
From Sept 1 , 2010 , to Nov 29 , 2012 , we enrolled 336 patients ( 168 assigned to each group ) . | RESULTS |
This is the first intervention to report improved ART adherence , viral suppression , and reduced secondary sexual transmission risk behavior . | CONCLUSIONS |
Tolerability was assessed throughout the study by physical and ophthalmologic examinations , vital signs measurement , laboratory analyses , and monitoring of adverse effects . | METHODS |
The ICER at 3 years was $ 297,800 / QALY for bilateral disease , driven by the high cost of implant therapy ( difference implant - systemic [ ] : $ 16,900 ; P < 0.001 ) and the modest gains in QALYs ( = 0.057 ; P = 0.22 ) . | RESULTS |
This midostaurin drug-drug interaction study assessed the dynamic response and clinical usefulness of urinary 6-hydroxycortisol to cortisol ratio ( 6CR ) and plasma 4-hydroxycholesterol ( 4HC ) for monitoring CYP3A4 activity in the presence or absence of rifampicin , a strong CYP3A4 inducer . | OBJECTIVE |
The role of a selective duplex ultrasound imaging policy is unknown . | BACKGROUND |
Five participants experienced serious AEs during the open-label extension ; none was related/possibly related to treatment . | RESULTS |
A double-blind , randomized clinical trial was performed with 54 participants treated with 10mg rosuvastatin for 4 months with or without zinc supplementation ( 30mg/day ) . | METHODS |
After 24 weeks of treatment by BQD or QQD , ASAS20 standard rate was 86.75 % in the treatment group , and the total effective rate of Chinese medical syndrome was 85.47 % . | RESULTS |
ACTR.org.au ACTRN12608000628347 . | BACKGROUND |
In an AS-nave population , 18 months of ZdA treatment prevented the sustained BMD losses caused by 18 months of AS treatment ; however , the study power was insufficient to show that AS duration or ZdA influenced vertebral fracture rates . | CONCLUSIONS |
Group LACB ( n = 45 ) had standard quadruple regimen treatment : lansoprazole 30 mg + amoxicillin 1000 mg + clarithromycin 500 mg + bismuth potassium citrate 220 mg , twice daily for 10 days ( d1-10 ) . | METHODS |
Many patients with PD are treated with antidepressants for NMSs , and the effect of the combination of PD medications that enhance dopamine neurotransmission and antidepressants on NMSs has not been studied . | OBJECTIVE |
Each group will receive 10 sessions of 30 minutes each ( 2 sessions per week over 5 weeks ) . | METHODS |
Our secondary aims were to examine phenotypic associations with 30-day postoperative patient cultures , phenotypic growth rates , and risk factors for phenotypic isolation . | BACKGROUND |
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