Popular Vote (popV) model for automated cell type annotation of single-cell RNA-seq data. We provide here pretrained models for plug-in use in your own analysis. Follow our tutorial to learn how to use the model for cell type annotation.

Model description

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence, genomic instability and changes in the immune system. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

Link to CELLxGENE: Link to the data in the CELLxGENE browser for interactive exploration of the data and download of the source data.

Training Code URL: Not provided by uploader.

Metrics

We provide here accuracies for each of the experts and the ensemble model. The validation set accuracies are computed on a 10% random subset of the data that was not used for training.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
B cell 3058 0.94 0.92 0.89 0.92 0.00 0.89 0.86 0.88 0.94
mesenchymal stem cell 1519 0.91 0.82 0.94 0.87 0.00 0.75 0.94 0.90 0.96
granulocyte 1251 0.89 0.89 0.83 0.83 0.00 0.88 0.80 0.86 0.91
basal cell of epidermis 1143 0.89 0.91 0.89 0.93 0.00 0.81 0.90 0.84 0.95
T cell 1143 0.85 0.81 0.77 0.73 0.00 0.76 0.72 0.78 0.86
keratinocyte 1118 0.90 0.85 0.91 0.91 0.00 0.81 0.91 0.87 0.96
endothelial cell 1041 0.89 0.89 0.84 0.88 0.00 0.83 0.96 0.90 0.95
classical monocyte 799 0.83 0.54 0.77 0.70 0.00 0.64 0.85 0.86 0.93
granulocytopoietic cell 771 0.78 0.80 0.81 0.80 0.00 0.82 0.77 0.81 0.86
macrophage 728 0.69 0.64 0.68 0.69 0.00 0.55 0.69 0.73 0.81
bladder urothelial cell 546 0.99 1.00 0.93 0.95 0.00 0.96 1.00 0.99 1.00
proerythroblast 450 0.64 0.69 0.64 0.55 0.00 0.71 0.61 0.68 0.76
kidney proximal convoluted tubule epithelial cell 431 0.84 0.86 0.80 0.84 0.00 0.84 0.89 0.87 0.87
endothelial cell of coronary artery 329 0.77 0.84 0.70 0.80 0.00 0.69 0.96 0.88 0.93
epithelial cell of proximal tubule 307 0.78 0.84 0.70 0.75 0.00 0.81 0.89 0.84 0.84
bladder cell 299 0.98 0.97 0.89 0.80 0.00 0.68 0.99 0.97 0.99
mature NK T cell 276 0.65 0.70 0.54 0.40 0.00 0.61 0.59 0.71 0.74
hepatocyte 300 1.00 1.00 1.00 0.98 0.00 0.99 1.00 0.99 1.00
erythroblast 272 0.67 0.69 0.71 0.67 0.00 0.74 0.70 0.74 0.77
promonocyte 285 0.81 0.78 0.83 0.78 0.00 0.78 0.88 0.89 0.92
stromal cell 272 0.70 0.28 0.89 0.65 0.00 0.63 0.94 0.77 0.89
megakaryocyte-erythroid progenitor cell 268 0.63 0.67 0.53 0.70 0.00 0.67 0.68 0.65 0.72
type B pancreatic cell 269 0.91 0.88 0.76 0.98 0.00 0.97 0.99 0.99 0.99
Kupffer cell 263 0.97 0.51 0.76 0.77 0.00 0.84 0.98 0.96 0.97
natural killer cell 267 0.89 0.88 0.78 0.81 0.00 0.82 0.88 0.88 0.91
professional antigen presenting cell 274 0.00 0.01 0.15 0.07 0.00 0.01 0.54 0.49 0.06
fibroblast of cardiac tissue 246 0.97 0.97 0.90 0.68 0.00 0.66 0.98 0.95 0.98
monocyte 246 0.77 0.50 0.78 0.38 0.00 0.59 0.92 0.85 0.90
bronchial smooth muscle cell 221 0.96 0.96 0.86 0.93 0.00 0.97 0.97 0.95 0.97
hematopoietic precursor cell 210 0.59 0.70 0.50 0.53 0.00 0.66 0.71 0.79 0.78
pancreatic acinar cell 228 0.99 0.97 0.55 0.99 0.00 0.99 1.00 1.00 1.00
skeletal muscle satellite cell 183 0.99 0.99 0.95 0.97 0.00 0.96 0.99 0.98 0.99
DN4 thymocyte 195 0.23 0.04 0.45 0.23 0.00 0.00 0.59 0.61 0.33
luminal epithelial cell of mammary gland 180 0.93 0.91 0.93 0.91 0.00 0.91 0.99 0.95 0.96
mesenchymal stem cell of adipose tissue 188 0.64 0.49 0.68 0.58 0.00 0.15 0.93 0.74 0.89
thymocyte 175 0.97 0.50 0.89 0.95 0.00 0.94 0.98 0.93 0.98
myeloid cell 234 0.56 0.07 0.51 0.47 0.00 0.03 0.86 0.80 0.71
fibroblast 179 0.61 0.11 0.67 0.64 0.00 0.56 0.69 0.70 0.79
immature T cell 172 0.90 0.74 0.86 0.94 0.00 0.96 0.94 0.88 0.95
intermediate monocyte 176 0.66 0.27 0.62 0.61 0.00 0.65 0.60 0.64 0.77
epidermal cell 175 0.94 0.00 0.88 0.93 0.00 0.89 0.93 0.89 0.96
chondrocyte 160 0.87 0.00 0.86 0.84 0.00 0.88 0.88 0.89 0.89
plasma cell 153 0.65 0.66 0.66 0.69 0.00 0.54 0.57 0.66 0.76
smooth muscle cell 171 0.74 0.81 0.79 0.81 0.00 0.80 0.87 0.82 0.83
lymphocyte 147 0.24 0.24 0.30 0.20 0.00 0.03 0.30 0.44 0.38
basal cell 156 0.98 0.98 0.96 0.95 0.00 0.96 0.99 0.97 0.99
naive T cell 151 0.80 0.90 0.89 0.90 0.00 0.89 0.89 0.88 0.90
kidney loop of Henle thick ascending limb epithelial cell 152 0.92 0.92 0.89 0.92 0.00 0.83 0.90 0.90 0.93
fibroblast of lung 146 0.95 0.92 0.96 0.94 0.00 0.96 0.99 0.97 0.97
leukocyte 142 0.66 0.65 0.53 0.42 0.00 0.45 0.78 0.78 0.82
alveolar macrophage 131 0.98 0.98 0.99 0.95 0.00 0.97 0.99 0.98 0.99
lung macrophage 127 0.89 0.05 0.61 0.50 0.00 0.84 0.86 0.88 0.94
enterocyte of epithelium of large intestine 98 0.96 0.69 0.87 0.92 0.00 0.94 0.98 0.94 0.97
non-classical monocyte 93 0.76 0.78 0.76 0.75 0.00 0.72 0.85 0.77 0.80
double negative thymocyte 80 0.74 0.00 0.40 0.65 0.00 0.77 0.84 0.78 0.88
precursor B cell 108 0.78 0.87 0.75 0.81 0.00 0.88 0.95 0.93 0.90
mesenchymal cell 98 0.28 0.00 0.11 0.07 0.00 0.15 0.45 0.55 0.38
CD8-positive, alpha-beta T cell 78 0.53 0.68 0.26 0.20 0.00 0.50 0.65 0.71 0.70
immature B cell 85 0.96 0.91 0.93 0.92 0.00 0.89 0.66 0.86 0.96
kidney collecting duct principal cell 68 0.64 0.99 0.93 0.93 0.00 0.86 0.94 0.95 0.98
kidney distal convoluted tubule epithelial cell 69 0.00 0.97 0.88 0.91 0.00 0.89 0.91 0.88 0.93
endocardial cell 62 0.92 0.96 0.88 0.94 0.00 0.88 0.95 0.82 0.96
endothelial cell of hepatic sinusoid 52 0.97 0.93 0.78 0.83 0.00 0.72 0.98 0.91 0.93
neutrophil 62 0.63 0.62 0.68 0.71 0.00 0.85 0.91 0.79 0.84
CD4-positive, alpha-beta T cell 49 0.00 0.30 0.17 0.19 0.00 0.23 0.39 0.37 0.43
late pro-B cell 59 0.78 0.80 0.45 0.69 0.00 0.85 0.78 0.79 0.88
adventitial cell 47 0.71 0.47 0.79 0.41 0.00 0.37 0.87 0.68 0.85
basal epithelial cell of tracheobronchial tree 48 0.97 0.06 0.91 0.83 0.00 0.68 0.98 0.93 0.99
plasmatocyte 39 0.77 0.78 0.67 0.87 0.00 0.53 0.85 0.81 0.92
keratinocyte stem cell 42 0.84 0.00 0.72 0.89 0.00 0.86 0.91 0.77 0.91
brush cell 35 0.86 0.83 0.67 0.83 0.00 0.86 0.84 0.76 0.88
erythroid progenitor cell, mammalian 37 0.78 0.00 0.48 0.39 0.00 0.23 0.71 0.60 0.89
naive B cell 38 0.95 0.96 0.88 0.92 0.00 0.82 0.87 0.91 0.94
kidney cortex artery cell 37 0.76 0.85 0.33 0.67 0.00 0.54 0.76 0.67 0.84
erythrocyte 30 0.63 0.49 0.71 0.62 0.00 0.38 0.83 0.71 0.81
intestinal crypt stem cell 29 0.57 0.00 0.17 0.77 0.00 0.51 0.89 0.83 0.86
epithelial cell 30 0.65 0.04 0.75 0.66 0.00 0.67 0.92 0.78 0.80
pancreatic ductal cell 28 0.78 0.56 0.80 0.85 0.00 0.83 0.86 0.86 0.84
cardiac muscle cell 32 0.98 0.97 1.00 1.00 0.00 0.93 0.98 0.97 0.98
vein endothelial cell 32 0.54 0.76 0.50 0.71 0.00 0.67 0.87 0.79 0.81
pancreatic A cell 37 0.00 0.00 0.24 0.93 0.00 0.84 0.92 0.93 0.92
myeloid leukocyte 28 0.51 0.07 0.49 0.06 0.00 0.06 0.60 0.81 0.87
Schwann cell 22 0.75 0.23 0.84 0.83 0.00 0.90 0.81 0.75 0.79
pancreatic D cell 21 0.33 0.37 0.36 0.91 0.00 0.86 0.91 0.98 0.93
mesangial cell 28 0.00 0.80 0.51 0.67 0.00 0.70 0.92 0.87 0.91
basophil 28 0.67 0.77 0.85 0.65 0.00 0.55 0.66 0.74 0.85
myeloid dendritic cell 37 0.35 0.68 0.29 0.48 0.00 0.46 0.81 0.73 0.83
epithelial cell of large intestine 25 0.00 0.08 0.28 0.73 0.00 0.75 0.83 0.81 0.88
pulmonary interstitial fibroblast 25 0.88 0.85 0.94 1.00 0.00 0.94 0.94 0.91 0.98
kidney loop of Henle ascending limb epithelial cell 21 0.00 0.27 0.21 0.23 0.00 0.41 0.45 0.54 0.30
cell of skeletal muscle 13 1.00 0.96 0.96 0.96 0.00 0.58 0.96 0.92 1.00
Langerhans cell 13 0.96 0.76 0.00 0.58 0.00 0.39 0.87 0.83 0.92
stem cell of epidermis 9 0.49 0.00 0.80 0.86 0.00 0.13 0.82 0.56 0.86
kidney capillary endothelial cell 19 0.29 0.54 0.32 0.41 0.00 0.28 0.38 0.35 0.34
large intestine goblet cell 18 0.00 0.00 0.62 0.91 0.00 0.89 1.00 0.94 0.97
pancreatic PP cell 14 0.00 0.00 0.00 0.88 0.00 0.76 0.86 0.92 0.93
macrophage dendritic cell progenitor 25 0.00 0.52 0.16 0.38 0.00 0.70 0.69 0.49 0.70
DN3 thymocyte 15 0.93 0.85 0.00 0.93 0.00 0.85 0.86 0.85 0.93
smooth muscle cell of trachea 11 0.00 0.00 0.38 0.38 0.00 0.12 0.62 0.64 0.31
regulatory T cell 11 0.00 0.00 0.00 0.00 0.00 0.23 0.20 0.21 0.00
plasmacytoid dendritic cell 16 0.48 0.40 0.17 0.32 0.00 0.59 0.65 0.32 0.64
smooth muscle cell of the pulmonary artery 6 0.00 0.80 0.67 0.46 0.00 0.45 0.86 0.62 0.80
kidney proximal straight tubule epithelial cell 7 0.00 0.00 0.00 0.00 0.00 0.00 0.24 0.21 0.00
blood cell 11 0.00 0.00 0.00 0.14 0.00 0.00 0.27 0.31 0.00
immature NK T cell 6 0.29 0.22 0.33 0.25 0.00 0.10 0.32 0.57 0.40
cardiac neuron 7 0.00 0.22 0.40 0.24 0.00 0.24 0.48 0.59 0.44
mast cell 4 0.00 0.00 0.16 0.00 0.00 0.17 0.60 0.43 0.31
pericyte 8 1.00 0.94 0.93 0.94 0.00 0.94 0.70 1.00 1.00
ciliated columnar cell of tracheobronchial tree 3 0.00 0.04 0.75 0.86 0.00 0.55 0.14 1.00 1.00
neuroendocrine cell 7 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.17 0.00
dendritic cell 8 0.00 0.00 0.36 0.00 0.00 0.19 0.67 0.47 0.55
endothelial cell of lymphatic vessel 3 0.00 0.50 0.80 0.00 0.00 0.14 0.67 0.36 0.80
hepatic stellate cell 3 0.00 0.00 0.80 0.67 0.00 0.22 1.00 0.80 0.80
hematopoietic stem cell 5 0.00 0.00 0.00 0.33 0.00 0.38 0.55 0.67 0.57
kidney collecting duct epithelial cell 2 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
pancreatic stellate cell 1 0.00 0.00 0.00 0.00 0.00 0.04 1.00 0.00 0.00
club cell 1 0.15 0.00 0.00 0.00 0.00 0.07 0.00 0.15 0.17
lung neuroendocrine cell 1 0.00 0.00 1.00 1.00 0.00 0.00 0.15 1.00 1.00
kidney cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
duct epithelial cell 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00

The train accuracies are computed on the training data.

Cell Type N cells celltypist knn bbknn knn harmony knn on scvi onclass scanvi svm xgboost Consensus Prediction
B cell 27660 0.94 0.91 0.94 0.95 0.00 0.95 0.88 0.89 0.96
mesenchymal stem cell 13194 0.90 0.80 0.97 0.91 0.00 0.85 0.94 0.91 0.96
granulocyte 11345 0.88 0.88 0.94 0.93 0.00 0.91 0.81 0.86 0.92
basal cell of epidermis 10288 0.89 0.88 0.94 0.95 0.00 0.87 0.89 0.85 0.95
T cell 10273 0.83 0.77 0.82 0.87 0.00 0.89 0.75 0.78 0.92
keratinocyte 10024 0.89 0.83 0.95 0.95 0.00 0.87 0.91 0.88 0.96
endothelial cell 8853 0.89 0.86 0.89 0.93 0.00 0.92 0.96 0.91 0.97
classical monocyte 7123 0.85 0.48 0.86 0.90 0.00 0.90 0.86 0.86 0.94
granulocytopoietic cell 6828 0.80 0.75 0.93 0.91 0.00 0.85 0.80 0.83 0.90
macrophage 6456 0.69 0.62 0.84 0.82 0.00 0.84 0.72 0.75 0.87
bladder urothelial cell 4685 0.99 0.99 1.00 0.98 0.00 0.99 1.00 0.99 1.00
proerythroblast 4120 0.66 0.68 0.85 0.82 0.00 0.83 0.66 0.73 0.82
kidney proximal convoluted tubule epithelial cell 4029 0.86 0.82 0.89 0.89 0.00 0.89 0.92 0.91 0.92
endothelial cell of coronary artery 2960 0.77 0.81 0.81 0.89 0.00 0.98 0.97 0.91 0.98
epithelial cell of proximal tubule 2746 0.80 0.71 0.84 0.83 0.00 0.85 0.89 0.87 0.89
bladder cell 2704 0.97 0.97 1.00 0.88 0.00 0.91 0.99 0.97 0.99
mature NK T cell 2686 0.67 0.69 0.68 0.82 0.00 0.80 0.70 0.76 0.85
hepatocyte 2626 0.99 1.00 0.99 0.99 0.00 0.99 1.00 0.99 1.00
erythroblast 2646 0.70 0.72 0.84 0.87 0.00 0.91 0.76 0.81 0.87
promonocyte 2542 0.81 0.78 0.88 0.91 0.00 0.91 0.91 0.90 0.93
stromal cell 2511 0.71 0.01 0.98 0.77 0.00 0.83 0.94 0.81 0.93
megakaryocyte-erythroid progenitor cell 2444 0.70 0.73 0.83 0.84 0.00 0.87 0.76 0.77 0.86
type B pancreatic cell 2405 0.92 0.64 0.92 0.99 0.00 0.98 1.00 1.00 1.00
Kupffer cell 2283 0.97 0.39 0.84 0.91 0.00 0.98 0.99 0.98 0.99
natural killer cell 2217 0.85 0.84 0.76 0.87 0.00 0.89 0.89 0.90 0.92
professional antigen presenting cell 2208 0.00 0.00 0.31 0.35 0.00 0.97 0.56 0.50 0.46
fibroblast of cardiac tissue 2162 0.98 0.97 0.97 0.80 0.00 0.93 0.99 0.96 1.00
monocyte 2147 0.77 0.45 0.87 0.85 0.00 0.92 0.92 0.88 0.93
bronchial smooth muscle cell 2118 0.97 0.97 0.85 0.96 0.00 0.98 0.98 0.97 0.99
hematopoietic precursor cell 1934 0.57 0.68 0.67 0.83 0.00 0.91 0.74 0.84 0.90
pancreatic acinar cell 1912 0.98 0.97 0.91 1.00 0.00 0.99 1.00 0.99 1.00
skeletal muscle satellite cell 1872 0.98 0.98 0.99 0.98 0.00 0.99 0.98 0.97 0.99
DN4 thymocyte 1805 0.28 0.01 0.58 0.67 0.00 0.95 0.66 0.65 0.79
luminal epithelial cell of mammary gland 1723 0.93 0.88 0.97 0.96 0.00 0.97 0.98 0.97 0.98
mesenchymal stem cell of adipose tissue 1705 0.57 0.16 0.87 0.69 0.00 0.97 0.93 0.79 0.94
thymocyte 1717 0.98 0.13 0.93 0.98 0.00 0.98 0.99 0.97 0.99
myeloid cell 1637 0.57 0.01 0.73 0.70 0.00 0.96 0.89 0.83 0.92
fibroblast 1634 0.63 0.05 0.79 0.77 0.00 0.73 0.79 0.81 0.87
immature T cell 1612 0.91 0.37 0.94 0.97 0.00 0.97 0.97 0.94 0.97
intermediate monocyte 1573 0.64 0.23 0.69 0.78 0.00 0.71 0.65 0.65 0.81
epidermal cell 1560 0.93 0.00 0.94 0.94 0.00 0.93 0.90 0.89 0.96
chondrocyte 1470 0.84 0.00 0.89 0.88 0.00 0.89 0.92 0.92 0.93
plasma cell 1468 0.63 0.65 0.80 0.82 0.00 0.71 0.69 0.74 0.84
smooth muscle cell 1430 0.74 0.81 0.88 0.93 0.00 0.88 0.90 0.85 0.85
lymphocyte 1444 0.24 0.20 0.67 0.52 0.00 0.81 0.40 0.52 0.73
basal cell 1431 0.98 0.97 0.99 0.98 0.00 0.98 0.99 0.97 0.99
naive T cell 1417 0.78 0.91 0.94 0.94 0.00 0.91 0.91 0.91 0.93
kidney loop of Henle thick ascending limb epithelial cell 1402 0.93 0.93 0.94 0.93 0.00 0.92 0.97 0.96 0.95
fibroblast of lung 1377 0.94 0.91 0.95 0.97 0.00 0.99 0.99 0.98 0.99
leukocyte 1354 0.64 0.53 0.74 0.68 0.00 0.91 0.83 0.81 0.93
alveolar macrophage 1235 0.98 0.96 0.98 0.97 0.00 0.97 0.98 0.97 0.99
lung macrophage 1030 0.89 0.03 0.79 0.87 0.00 0.95 0.90 0.89 0.96
enterocyte of epithelium of large intestine 1027 0.95 0.00 0.94 0.96 0.00 0.97 1.00 0.99 1.00
non-classical monocyte 917 0.77 0.78 0.90 0.91 0.00 0.90 0.90 0.86 0.89
double negative thymocyte 891 0.72 0.00 0.65 0.86 0.00 0.88 0.91 0.86 0.93
precursor B cell 807 0.78 0.85 0.86 0.95 0.00 0.94 0.96 0.95 0.95
mesenchymal cell 781 0.26 0.00 0.44 0.31 0.00 0.40 0.55 0.62 0.62
CD8-positive, alpha-beta T cell 792 0.49 0.55 0.43 0.69 0.00 0.84 0.80 0.81 0.91
immature B cell 741 0.94 0.89 0.94 0.93 0.00 0.90 0.69 0.87 0.94
kidney collecting duct principal cell 721 0.65 0.94 0.96 0.96 0.00 0.91 0.99 0.98 0.98
kidney distal convoluted tubule epithelial cell 675 0.00 0.92 0.93 0.94 0.00 0.94 0.98 0.98 0.96
endocardial cell 615 0.89 0.90 0.92 0.93 0.00 0.95 0.96 0.85 0.98
endothelial cell of hepatic sinusoid 622 0.97 0.95 0.82 0.90 0.00 0.87 0.99 0.98 0.99
neutrophil 490 0.64 0.57 0.95 0.92 0.00 0.94 0.95 0.86 0.95
CD4-positive, alpha-beta T cell 502 0.00 0.28 0.51 0.63 0.00 0.69 0.59 0.58 0.88
late pro-B cell 473 0.77 0.76 0.67 0.87 0.00 0.91 0.91 0.89 0.96
adventitial cell 479 0.78 0.54 0.94 0.67 0.00 0.71 0.90 0.78 0.95
basal epithelial cell of tracheobronchial tree 473 0.95 0.00 0.99 0.90 0.00 0.99 0.98 0.97 0.99
plasmatocyte 457 0.74 0.81 0.92 0.89 0.00 0.66 0.91 0.92 0.97
keratinocyte stem cell 376 0.87 0.00 0.94 0.93 0.00 0.90 0.91 0.76 0.97
brush cell 379 0.91 0.76 0.95 0.92 0.00 0.92 0.92 0.88 0.97
erythroid progenitor cell, mammalian 372 0.79 0.00 0.93 0.81 0.00 0.33 0.80 0.64 0.94
naive B cell 360 0.88 0.90 0.95 0.94 0.00 0.87 0.93 0.96 0.96
kidney cortex artery cell 344 0.80 0.88 0.83 0.77 0.00 0.68 0.81 0.73 0.86
erythrocyte 326 0.74 0.47 0.85 0.92 0.00 0.78 0.88 0.80 0.94
intestinal crypt stem cell 310 0.68 0.00 0.87 0.88 0.00 0.79 1.00 0.99 0.99
epithelial cell 308 0.70 0.02 0.93 0.85 0.00 0.91 0.95 0.91 0.97
pancreatic ductal cell 307 0.82 0.56 0.96 0.95 0.00 0.95 0.97 0.94 0.97
cardiac muscle cell 302 1.00 1.00 1.00 0.99 0.00 0.90 1.00 0.99 1.00
vein endothelial cell 288 0.57 0.79 0.84 0.82 0.00 0.84 0.92 0.88 0.94
pancreatic A cell 272 0.00 0.00 0.71 0.92 0.00 0.95 0.99 0.98 0.99
myeloid leukocyte 278 0.51 0.06 0.89 0.51 0.00 0.94 0.69 0.87 0.96
Schwann cell 252 0.75 0.23 0.95 0.90 0.00 0.95 0.89 0.85 0.91
pancreatic D cell 250 0.39 0.16 0.87 0.95 0.00 0.93 0.99 0.99 0.97
mesangial cell 233 0.00 0.84 0.77 0.85 0.00 0.75 0.94 0.93 0.98
basophil 226 0.59 0.63 0.89 0.86 0.00 0.78 0.78 0.81 0.86
myeloid dendritic cell 208 0.33 0.64 0.84 0.62 0.00 0.64 0.81 0.78 0.93
epithelial cell of large intestine 204 0.00 0.00 0.72 0.81 0.00 0.85 0.99 0.96 0.97
pulmonary interstitial fibroblast 197 0.88 0.86 0.96 0.96 0.00 0.95 0.89 0.97 0.98
kidney loop of Henle ascending limb epithelial cell 180 0.00 0.23 0.41 0.16 0.00 0.63 0.82 0.81 0.54
cell of skeletal muscle 179 0.98 0.94 0.98 0.95 0.00 0.74 0.98 0.97 0.98
Langerhans cell 162 0.92 0.79 0.97 0.86 0.00 0.84 0.96 0.87 1.00
stem cell of epidermis 162 0.68 0.00 0.81 0.84 0.00 0.40 0.91 0.78 0.93
kidney capillary endothelial cell 142 0.23 0.34 0.46 0.35 0.00 0.24 0.30 0.30 0.28
large intestine goblet cell 140 0.00 0.00 0.94 0.97 0.00 0.87 1.00 1.00 1.00
pancreatic PP cell 143 0.00 0.00 0.71 0.90 0.00 0.93 0.99 0.98 0.99
macrophage dendritic cell progenitor 123 0.00 0.20 0.41 0.79 0.00 0.79 0.86 0.84 0.87
DN3 thymocyte 131 0.83 0.49 0.87 0.91 0.00 0.96 0.97 0.91 0.97
smooth muscle cell of trachea 116 0.00 0.00 0.50 0.55 0.00 0.81 0.89 0.88 0.86
regulatory T cell 112 0.00 0.05 0.18 0.38 0.00 0.49 0.56 0.42 0.77
plasmacytoid dendritic cell 100 0.38 0.32 0.45 0.78 0.00 0.77 0.87 0.81 0.92
smooth muscle cell of the pulmonary artery 92 0.00 0.67 0.88 0.70 0.00 0.73 0.96 0.84 0.93
kidney proximal straight tubule epithelial cell 88 0.00 0.00 0.14 0.02 0.00 0.66 0.61 0.48 0.41
blood cell 77 0.00 0.00 0.39 0.34 0.00 0.27 0.44 0.36 0.57
immature NK T cell 78 0.29 0.06 0.66 0.66 0.00 0.31 0.50 0.56 0.77
cardiac neuron 74 0.00 0.27 0.92 0.72 0.00 0.78 0.76 0.91 0.96
mast cell 72 0.00 0.00 0.87 0.76 0.00 0.73 0.86 0.78 0.94
pericyte 53 0.98 0.85 0.92 0.92 0.00 0.97 0.63 0.94 0.99
ciliated columnar cell of tracheobronchial tree 54 0.00 0.05 0.69 0.95 0.00 0.93 0.41 1.00 0.97
neuroendocrine cell 41 0.00 0.00 0.25 0.28 0.00 0.76 0.99 0.76 0.61
dendritic cell 37 0.00 0.00 0.59 0.49 0.00 0.30 0.79 0.69 0.93
endothelial cell of lymphatic vessel 38 0.00 0.30 0.93 0.65 0.00 0.20 0.75 0.52 0.97
hepatic stellate cell 36 0.00 0.05 0.81 0.91 0.00 0.48 0.99 0.99 0.99
hematopoietic stem cell 31 0.00 0.00 0.28 0.73 0.00 0.45 0.78 0.87 0.97
kidney collecting duct epithelial cell 23 0.00 0.00 0.08 0.00 0.00 0.73 1.00 0.92 0.16
pancreatic stellate cell 20 0.00 0.00 0.71 0.26 0.00 0.23 0.89 1.00 0.97
club cell 14 0.07 0.00 0.25 0.11 0.00 0.17 0.21 0.20 0.15
lung neuroendocrine cell 3 0.00 0.00 1.00 0.80 0.00 0.60 0.03 1.00 1.00
kidney cell 3 0.00 0.00 0.00 0.00 0.00 0.60 0.02 0.86 0.80
duct epithelial cell 2 0.00 0.00 0.00 0.00 0.00 0.57 1.00 0.07 0.00

References

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, The Tabula Muris Consortium, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, Ben A. Barres, Philip A. Beachy, Daniela Berdnik, Biter Bilen, Douglas Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, Michael F. Clarke, Stephanie D. Conley, Spyros Darmanis, Aaron Demers, Kubilay Demir, Antoine de Morree, Tessa Divita, Haley du Bois, Hamid Ebadi, F. Hernán Espinoza, Matt Fish, Qiang Gan, Benson M. George, Astrid Gillich, Rafael Gòmez-Sjöberg, Foad Green, Geraldine Genetiano, Xueying Gu, Gunsagar S. Gulati, Oliver Hahn, Michael Seamus Haney, Yan Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, Kerwyn Casey Huang, Tal Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Jim Karkanias, Guruswamy Karnam, Andreas Keller, Aaron M. Kershner, Nathalie Khoury, Seung K. Kim, Bernhard M. Kiss, William Kong, Mark A. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Lam, Davis P. Lee, Song E. Lee, Benoit Lehallier, Olivia Leventhal, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, Anoop Manjunath, Andrew P. May, Ashley Maynard, Aaron McGeever, Marina McKay, M. Windy McNerney, Bryan Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, Ahmad N. Nabhan, Norma F. Neff, Katharine M. Ng, Patricia K. Nguyen, Joseph Noh, Roel Nusse, Róbert Pálovics, Rasika Patkar, Weng Chuan Peng, Lolita Penland, Angela Oliveira Pisco, Katherine Pollard, Robert Puccinelli, Zhen Qi, Stephen R. Quake, Thomas A. Rando, Eric J. Rulifson, Nicholas Schaum, Joe M. Segal, Shaheen S. Sikandar, Rahul Sinha, Rene V. Sit, Justin Sonnenburg, Daniel Staehli, Krzysztof Szade, Michelle Tan, Weilun Tan, Cristina Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, Kyle J. Travaglini, Carolina Tropini, Margaret Tsui, Lucas Waldburger, Bruce M. Wang, Linda J. van Weele, Kenneth Weinberg, Irving L. Weissman, Michael N. Wosczyna, Sean M. Wu, Tony Wyss-Coray, Jinyi Xiang, Soso Xue, Kevin A. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chunyu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou; Nature, doi: https://doi.org/10.1038/s41586-020-2496-1

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