Patent Document

BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     2. Discussion of Related Art 
     A cleaning disinfectant 
     This invention relates to a cleaning, water-containing disinfectant based on reaction products of 
     a) N-substituted propylenediamines corresponding to formula I: 
     
         R.sub.2 --NH--CH.sub.2 --CH.sub.2 --CH.sub.2 --NH.sub.2    (II) 
    
     in which R 1  is a linear alkyl radical containing 12 to 14 carbon atoms, and 
     b) compounds corresponding to formula II: 
     
         R.sub.2 --O--CO--CH.sub.2 --CH.sub.2 --CH(NH.sub.2)--COOH  (II) 
    
     in which R 2  is a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms, 
     the molar ratio of a) to b).being about 1:1 to about 1:2, (composition U) and/or salts thereof with inorganic or organic acids, optionally together with nonionic and/or amphoteric surfactants, complexing agents and organic solvents according to EP 156 275, characterized in that it contains benzyl and/or 2-phenoxyethanol and/or 1-phenoxypropanol as solubilizer. 
     The preparation and use of composition U are described in EP 156 275. Active-substance combinations containing U are known from WO 91/13965. However, it has been found that the solutions mentioned therein do not always dissolve clearly in water at room temperature either on its own or in conjunction with typical solvents, such as alcohols and glycol ethers, for example ethanol, propanol, isopropanol or butyl diglycol (diethylene glycol monobutyl ether) and separate into layers in the event of prolonged storage. This is attributable to the unfavorable temperature-dependent clear and cloud point of the solutions. 
     DESCRIPTION OF THE INVENTION 
     It has now been found that clear cleaning disinfectants can be obtained if, in addition to the usual solvents, benzyl alcohol and/or 2-phenoxyethanol and/or 1-phenoxypropanol is/are used as solubilizers for the composition U. A mixture of benzyl alcohol and 1-phenoxypropanol, more particularly in a quantity ratio of around 1:1, is preferably used. 
     The quantity of solubilizer in the disinfectant as a whole is about 3 to about 30% by weight and preferably about 7 to about 15% by weight. The ratio by weight of solubilizer to U is about 1.0:6.0 to 1.0:0.05 and preferably of the order of 1:0.5 to 1:0.07. 
     By using these alcohols as solubilizers, the clear point of the disinfectant solutions in typical solvents could be reduced to temperatures well below 20° C. They remained stable in storage over an observation period of around 6 months. 
     This favorable result remained intact even when nonionic surfactants, builders and optionally fragrances and/or corrosion inhibitors were added to the solutions. 
     The composition U is used in quantities of around 5 to 40% by weight and preferably in quantities of around 10 to 25% by weight. 
     If a cleaning effect is required in addition to the antimicrobial effect, the disinfectants may contain one or more surfactants, preferably from the groups of nonionic surfactants and amphoteric surfactants. 
     Suitable nonionic surfactants are, for example, alkyl polyglycosides preferably containing 8 to 22 carbon atoms in the alkyl radical, reaction products of 4 to 40 and preferably 4 to 20 mole equivalents of ethylene oxide (EO) and/or propylene oxide (PO) with fatty alcohols, fatty acids, fatty amines, fatty acid amides or alkane sulfonamides, of which the fatty alkyl radicals preferably contain 8 to 22 carbon atoms, and with alkylphenols. The end-capped derivatives of such alkoxylation products, preferably with terminal groups containing 2 to 10 carbon atoms, are also suitable. Addition products of 5 to 16 moles of ethylene oxide with cocofatty alcohols or tallow fatty alcohols, with oleyl alcohol and with mono-, di- or trialkylphenols and with monoalkyl cyclohexanols containing 6 to 14 carbon atoms in the alkyl radicals are of particular interest. It can be of advantage to use the lowest foaming representatives of this group. 
     Nonionic surfactants of the type in question include, for example, the commercial products Dehypon® LS 24, LS 36, LS 45, LS 54, LT 24, LT 104, OCP 502 (supplier: Henkel), Dehydol® LT 30 (supplier: Henkel), Lutensol® LF 224, LT 30 (supplier: BASF), Triton® CF 54 and DF 12 (supplier: Rohm &amp; Haas). 
     The nonionic surfactants are used in quantities of around 3 to 20% by weight and preferably in quantities of around 5 to 10% by weight. 
     Suitable amphoteric surfactants include derivatives of tertiary aliphatic amines or quaternary aliphatic ammonium compounds, of which the aliphatic radicals may be linear or branched and of which one bears a carboxy, sulfo, phosphono, sulfato or phosphato group. Examples of such amphoteric surfactants are dimethyl tetradecyl glycine, dimethyl hexadecyl glycine, dimethyl octadecyl glycine, 3-(dimethyldodecylammonio)-1-propane sulfonate and the amphoteric surfactants marketed under the names of Dehyton® AB, CB and G (supplier: Henkel). They are used in quantities of around 0 to 10% by weight and preferably in quantities of around 2 to 5% by weight. 
     In order to guarantee a clear in-use solution and favorable corrosion behavior, even where the disinfectant concentrates according to the invention are used with hot water, the cleaning disinfectants according to the invention may contain complexing agents and corrosion inhibitors, preferably selected from the groups of phosphonic acids, aminocarboxylic acids and salts thereof, more particularly alkali metal salts. Suitable complexing agents are, for example, the alkali metal salts and preferably the sodium salts of methane diphosphonic acid, hydroxyethane-1,1-diphosphonic acid, 1-aminoethane-1,1-diphosphonic acid, aminotri(methylene-phosphonic acid), ethylenediamine tetra(methylenephosphonic acid), diethylenetriamine penta(methylenephosphonic acid), 2-phosphonobutane-1,2,4-tricarboxylic acid, nitrilotriacetic acid (NTA), ethylenediamine tetraacetic acid and hydroxyethyl ethylenediamine triacetic acid. NTA is preferred. 1,2,3-Benzotriazole may also be used as a pure corrosion inhibitor. Complexing agents and corrosion inhibitors such as these are preferably present in the disinfectants according to the invention in quantities of not more than 6% by weight and preferably in quantities of around 0.5% by weight to 3% by weight. 
     In addition, the cleaning disinfectant concentrates according to the invention may contain typical additives, such as dyes or fragrances. Typical additives such as these are preferably present in the disinfectants according to the invention in quantities of not more than 1% by weight. 
     In addition, the disinfectants according to the invention may contain water-soluble organic solvents, preferably from the groups of alcohols containing 1 to 4 carbon atoms, glycols containing 2 to 4 carbon atoms and the diglycols and diglycol ethers derived therefrom. Solvents of the type in question are, for example, methanol, ethanol, propanol, isopropanol, tert.butanol, ethylene glycol, propylene glycol, butylene glycol, diethylene glycol, dipropylene glycol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether and diethylene glycol monobutyl ether. Organic solvents may be used in quantities of around 5 to 35% by weight and preferably in quantities of around 10 to 20% by weight. Solvents and solubilizers are preferably present in the disinfectants according to the invention in quantities of not more than 40% by weight and, more preferably, in quantities of around 10% by weight to around 30% by weight. 
     DE 40 05 784 A1 describes disinfectant concentrates essentially containing 10 to 60% by weight of phenoxyethanol or a mixture of 2-phenoxy-1-propanol and 1-phenoxy-2-propanol, 0.5 to 50% by weight of a guadinium and/or a quaternary ammonium compound, 3 to 25% by weight of a nonionic surfactant and 0.1 to 10% by weight of an organic nitrogen-containing base, such as tetrabis-(2-hydroxypropyl)-N,N&#39;,N&#39;-ethylenediamine and their use as a mycobactericide and virucide. The effect of the mixture of phenoxyalkanol and quaternary ammonium compound is said to be enhanced in dependence upon the nitrogen-containing base used. Disclosures such as these are of no relevance to the present invention. By contrast, there is no reference in the prior art to solubility and improvements therein by benzyl alcohol and/or phenoxyalkanols. 
    
    
     EXAMPLES 
     Various formulations with the following composition: 
     25% by weight of composition U 
     5 to 10 % by weight of solvent 
     0 to 10 % by weight of solubilizer 
     7% by weight of C 12-14  alkyl 9EO butyl ether (Dehypon® LS 104 L) 
     0.5% by weight of 1,2,3-benzotriazole (Preventol® C8-100) 
     0.2% by weight of NTA balance to 100% by weight water 
     were prepared and cooled in quantities of 100 ml to a temperature of around 0° C. All the samples were cloudy. They were then slowly heated and the onset of the clear point in ° C. was determined. The results are set out in the following Table and illustrate the advantages of the solubilizers added in accordance with the invention. 
     
         __________________________________________________________________________   Alone    10% by weight in a ratio of 1:1   5% by       10% by            Butyl     Isopro-  Phenoxy-                                    Phenoxy-                                         Benzyl   weight       weight            diglycol                 Ethanol                      panol                          Propanol                               propanol                                    ethanol                                         alcohol__________________________________________________________________________Dimethyl   23  23   --   --   --  --   --   --   --formamide*)Methyl-2-   23  23   --   --   --  --   --   --   --pyrrolidonePolydiol   23  23   --   --   --  --   --   --   --Butanediol   22  22   --   --   --  --   --   --   --Propylene   23  23   --   --   --  --   --   --   --glycolButylene   23  23   --   --   --  --   --   --   --glycolGlycerol   21  21   --   --   --  --   --   --   --Butyl diglycol   15  14   --   13   11  11   10   11   11Ethanol 15  15   13   --   12  11   12   12   11Isopropanol   14  12   11   12   --  11   10   11   11Propanol   14  10   11   11   11  --   10   10    9Phenoxy 15   9   10   12   10  10   --    8    3propanol**)1-Phenoxy-   15  10   11   12   11  10    8   --    7ethanolBenzyl alcohol   10   7   11   11   11   9    3    7   --__________________________________________________________________________ *)Solvent **)Solubilizer

Technology Category: c