With no explanation, label text_A→text_B with either "not_related" or "related".
text_A: Sepsis is more fish among males than females.
text_B: Sepsis is a life-threatening condition that arises when the body 's response to infection causes injury to its own tissues and organs .. infection. infection. Common signs and symptoms include fever , increased heart rate , increased breathing rate , and confusion .. increased heart rate. tachycardia. increased breathing rate. hyperventilation. confusion. mental confusion. fever. fever. There also may be symptoms related to a specific infection , such as a cough with pneumonia , or painful urination with a kidney infection .. infection. infection. pneumonia. pneumonia. painful urination. dysuria. kidney infection. pyelonephritis. In the very young , old , and people with a weakened immune system , there may be no symptoms of a specific infection and the body temperature may be low or normal , rather than high .. infection. infection. weakened immune system. immunodeficiency. body temperature may be low. hypothermia. high. fever. Severe sepsis is sepsis causing poor organ function or insufficient blood flow .. poor organ function. organ dysfunction. Insufficient blood flow may be evident by low blood pressure , high blood lactate , or low urine output .. high. fever. low blood pressure. hypotension. blood lactate. blood lactate. low urine output. oliguria. Septic shock is low blood pressure due to sepsis that does not improve after reasonable amounts of intravenous fluids are given .. low blood pressure. hypotension. Septic shock. Septic shock. intravenous fluids. intravenous fluids. Sepsis is caused by an immune response triggered by an infection .. infection. infection. immune response. immune system. Most commonly , the infection is bacterial , but it may also be from fungi , viruses , or parasites .. infection. infection. fungi. fungi. viruses. viruses. parasites. parasites. Common locations for the primary infection include lungs , brain , urinary tract , skin , and abdominal organs .. infection. infection. urinary tract. urinary tract. abdominal organs. abdominal organs. Risk factors include young or old age , a weakened immune system from conditions such as cancer or diabetes , major trauma , or burns .. cancer. cancer. diabetes. diabetes mellitus. major trauma. major trauma. weakened immune system. immunodeficiency. An older method of diagnosis was based on meeting at least two systemic inflammatory response syndrome -LRB- SIRS -RRB- criteria due to a presumed infection .. infection. infection. systemic inflammatory response syndrome. systemic inflammatory response syndrome. In 2016 , SIRS was replaced with qSOFA which is two of the following three  : increased breathing rate , change in level of consciousness , and low blood pressure .. increased breathing rate. hyperventilation. qSOFA. qSOFA. low blood pressure. hypotension. Blood cultures are recommended preferably before antibiotics are started , however , infection of the blood is not required for the diagnosis .. antibiotics. antibiotics. infection. infection. Blood cultures. Blood cultures. infection of the blood. bacteremia. Medical imaging should be used to look for the possible location of infection .. infection. infection. Medical imaging. Medical imaging. Other potential causes of similar signs and symptoms include anaphylaxis , adrenal insufficiency , low blood volume , heart failure , and pulmonary embolism , among others .. anaphylaxis. anaphylaxis. adrenal insufficiency. adrenal insufficiency. low blood volume. hypovolemia. heart failure. heart failure. pulmonary embolism. pulmonary embolism. Sepsis usually is treated with intravenous fluids and antibiotics .. antibiotics. antibiotics. intravenous fluids. intravenous fluids. Typically , antibiotics are given as soon as possible .. antibiotics. antibiotics. Often , ongoing care is performed in an intensive care unit .. intensive care unit. intensive care unit. If fluid replacement is not enough to maintain blood pressure , medications that raise blood pressure may be used .. fluid replacement. fluid replacement. raise blood pressure. vasopressor. Mechanical ventilation and dialysis may be needed to support the function of the lungs and kidneys , respectively .. Mechanical ventilation. Mechanical ventilation. dialysis. dialysis. To guide treatment , a central venous catheter and an arterial catheter may be placed for access to the bloodstream .. central venous catheter. central venous catheter. arterial catheter. arterial catheter. Other measurements such as cardiac output and superior vena cava oxygen saturation may be used .. cardiac output. cardiac output. superior vena cava. superior vena cava. oxygen saturation. oxygen saturation ( medicine ). People with sepsis need preventive measures for deep vein thrombosis , stress ulcers and pressure ulcers , unless other conditions prevent such interventions .. deep vein thrombosis. deep vein thrombosis. Some might benefit from tight control of blood sugar levels with insulin .. blood sugar. blood sugar. insulin. insulin. The use of corticosteroids is controversial .. corticosteroids. corticosteroids. Activated drotrecogin alfa , originally marketed for severe sepsis , has not been found to be helpful , and was withdrawn from sale in 2011 .. Activated drotrecogin alfa. Activated drotrecogin alfa. Disease severity partly determines the outcome .. The risk of death from sepsis is as high as 30 % , from severe sepsis as high as 50 % , and from septic shock as high as 80 % .. high. fever. The number of cases worldwide is unknown as there is little data from the developing world .. developing world. developing world. Estimates suggest sepsis affects millions of people a year .. In the developed world approximately 0.2 to 3 people per 1000 are affected by sepsis yearly , resulting in about a million cases per year in the United States .. developed world. developed world. Rates of disease have been increasing .. Sepsis is more common among males than females .. The medical condition has been described since the time of Hippocrates .. Hippocrates. Hippocrates. Septicemia and blood poisoning are terms that referred to the microorganisms or their toxins in the blood and are no longer commonly used .
related.