With no explanation, label text_A→text_B with either "not_related" or "related".
text_A: Miami Beach is a municipality.
text_B: ChIP-on-chip -LRB- also known as ChIP-chip -RRB- is a technology that combines chromatin immunoprecipitation -LRB- ` ChIP ' -RRB- with DNA microarray -LRB- `` chip '' -RRB- .. chromatin immunoprecipitation. chromatin immunoprecipitation. DNA microarray. DNA microarray. ChIP. Ch-IP. DNA. DNA. chromatin. chromatin. Like regular ChIP , ChIP-on-chip is used to investigate interactions between proteins and DNA in vivo .. ChIP. Ch-IP. DNA. DNA. in vivo. in vivo. Specifically , it allows the identification of the cistrome , sum of binding sites , for DNA-binding proteins on a genome-wide basis .. DNA. DNA. cistrome. cistrome. genome. genome. Whole-genome analysis can be performed to determine the locations of binding sites for almost any protein of interest .. protein. protein. genome. genome. As the name of the technique suggests , such proteins are generally those operating in the context of chromatin .. chromatin. chromatin. The most prominent representatives of this class are transcription factors , replication-related proteins , like Origin Recognition Complex Protein -LRB- ORC -RRB- , histones , their variants , and histone modifications .. replication. DNA replication. ORC. Origin Recognition Complex Protein. histone. histone. The goal of ChIP-on-chip is to locate protein binding sites that may help identify functional elements in the genome .. ChIP. Ch-IP. protein. protein. genome. genome. For example , in the case of a transcription factor as a protein of interest , one can determine its transcription factor binding sites throughout the genome .. protein. protein. transcription factor. transcription factor. genome. genome. Other proteins allow the identification of promoter regions , enhancers , repressors and silencing elements , insulators , boundary elements , and sequences that control DNA replication .. DNA. DNA. replication. DNA replication. promoter regions. Promoter ( biology ). enhancers. Enhancer ( genetics ). repressors. repressors. silencing elements. Silencer ( DNA ). insulators. Chromatin insulation. If histones are subject of interest , it is believed that the distribution of modifications and their localizations may offer new insights into the mechanisms of regulation .. regulation. Gene regulation. One of the long-term goals ChIP-on-chip was designed for is to establish a catalogue of -LRB- selected -RRB- organisms that lists all protein-DNA interactions under various physiological conditions .. ChIP. Ch-IP. protein. protein. DNA. DNA. This knowledge would ultimately help in the understanding of the machinery behind gene regulation , cell proliferation , and disease progression .. regulation. Gene regulation. cell proliferation. cell proliferation. Hence , ChIP-on-chip offers not only huge potential to complement our knowledge about the orchestration of the genome on the nucleotide level , but also on higher levels of information and regulation as it is propagated by research on epigenetics .. ChIP. Ch-IP. genome. genome. regulation. Gene regulation. epigenetics. epigenetics. TOC
not_related.