A:Huntington's disease is an inherited disorder. B:Huntington 's disease -LRB- HD -RRB- , also known as Huntington 's chorea , is an inherited disorder that results in death of brain cells .. inherited disorder. inherited disorder. results in death of brain cells. neurodegenerative disease. The earliest symptoms are often subtle problems with mood or mental abilities .. A general lack of coordination and an unsteady gait often follow .. gait. gait. As the disease advances , uncoordinated , jerky body movements become more apparent .. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk .. Mental abilities generally decline into dementia .. dementia. dementia. The specific symptoms vary somewhat between people .. Symptoms usually begin between 30 and 50 years of age , but can start at any age .. The disease may develop earlier in life in each successive generation .. About 8 % of cases start before the age of 20 years and typically present with symptoms more similar to Parkinson 's disease .. People with HD often underestimate the degree of their problems .. HD is typically inherited from a person 's parents , with 10 % of cases due to a new mutation .. mutation. mutation. The disease is caused by an autosomal dominant mutation in either of an individual 's two copies of a gene called Huntingtin .. mutation. mutation. autosomal dominant. autosomal dominant. gene. gene. Huntingtin. Huntingtin. This means a child of an affected person typically has a 50 % chance of inheriting the disease .. The Huntingtin gene provides the genetic information for a protein that is also called `` huntingtin '' .. gene. gene. Huntingtin. Huntingtin. Expansion of CAG -LRB- cytosine-adenine-guanine -RRB- triplet repeats in the gene coding for the Huntingtin protein results in an abnormal protein , which gradually damages cells in the brain , through mechanisms that are not fully understood .. gene. gene. Huntingtin. Huntingtin. cytosine. cytosine. adenine. adenine. guanine. guanine. Diagnosis is by genetic testing , which can be carried out at any time , regardless of whether or not symptoms are present .. genetic testing. genetic testing. This fact raises several ethical debates  : the age at which an individual is considered mature enough to choose testing ; whether parents have the right to have their children tested ; and managing confidentiality and disclosure of test results .. There is no cure for HD .. Full-time care is required in the later stages of the disease .. Treatments can relieve some symptoms and in some improve quality of life .. quality of life. quality of life. The best evidence for treatment of the movement problems is with tetrabenazine .. tetrabenazine. tetrabenazine. HD affects about 4 to 15 in 100,000 people of European descent .. It is rare among Japanese , while the occurrence rate in Africa is unknown .. The disease affects men and women equally .. Complications such as pneumonia , heart disease , and physical injury from falls reduce life expectancy .. heart disease. heart disease. pneumonia. pneumonia. Suicide is the cause of death in about 9 % of cases .. Suicide. Suicide. Death typically occurs fifteen to twenty years from when the disease was first detected .. The first likely description of the disease was in 1841 by Charles Oscar Waters .. The condition was described in further detail in 1872 by George Huntington , after whom it is named .. George Huntington. George Huntington. The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation .. Hereditary Disease Foundation. Hereditary Disease Foundation. Research and support organizations began forming in the late 1960s to increase public awareness , to provide support for individuals and their families , and to promote research .. support. Support group. Current research directions include determining the exact mechanism of the disease , improving animal models to aid with research , testing of medications to treat symptoms or slow the progression of the disease , and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease .. animal models. animal models. stem cell therapy. Stem cell treatments Answer: reel
A:Precious premiered at a film festival. B:Precious  : Base on Nol by Saf -LRB- Based on the Novel `` Push '' by Sapphire -RRB- , or simply Precious , is a 2009 American drama film , directed and co-produced by Lee Daniels .. Lee Daniels. Lee Daniels. Push. Push ( 2009 film ). Sapphire. Sapphire ( author ). drama film. drama film. Precious is an adaptation by Geoffrey S. Fletcher of the 1996 novel Push by Sapphire .. Geoffrey S. Fletcher. Geoffrey S. Fletcher. Push. Push ( 2009 film ). Sapphire. Sapphire ( author ). The film stars Gabourey Sidibe , Mo'Nique , Paula Patton , and Mariah Carey .. Gabourey Sidibe. Gabourey Sidibe. Mo'Nique. Mo'Nique. Paula Patton. Paula Patton. Mariah Carey. Mariah Carey. This film marked the acting debut of Sidibe .. The film , then without a distributor , premiered to acclaim at both the 2009 Sundance Film Festival and the 2009 Cannes Film Festival , under its original title of Push  : Based on the Novel by Sapphire .. Push. Push ( 2009 film ). Sapphire. Sapphire ( author ). Sundance. 2009 Sundance Film Festival. Sundance Film Festival. Sundance Film Festival. 2009 Cannes Film Festival. 2009 Cannes Film Festival. At Sundance , it won the Audience Award and the Grand Jury Prize for best drama , as well as a Special Jury Prize for supporting actress Mo'Nique .. Mo'Nique. Mo'Nique. Sundance. 2009 Sundance Film Festival. After Precious '' ' screening at Sundance in January 2009 , Tyler Perry announced that he and Oprah Winfrey would be providing promotional assistance to the film , which was released through Lionsgate Entertainment .. Oprah Winfrey. Oprah Winfrey. Tyler Perry. Tyler Perry. Lionsgate. Lionsgate. Sundance. 2009 Sundance Film Festival. Lionsgate Entertainment. Lionsgate Entertainment. Precious won the People 's Choice Award at the Toronto International Film Festival in September .. Toronto International Film Festival. Toronto International Film Festival. The film 's title was changed from Push to Precious  : Based on the Novel `` Push '' by Sapphire , to avoid confusion with the 2009 action film Push .. Push. Push ( 2009 film ). Sapphire. Sapphire ( author ). Precious was also an official selection at the 62nd Cannes Film Festival -LRB- particularly the un certain regard section -RRB- .. Lionsgate gave the film a limited release in North America on November 6 , 2009 -LRB- the release was expanded on November 20 -RRB- .. Lionsgate. Lionsgate. Precious received largely positive reviews from critics ; the acting , the story , and its message were generally praised .. In the film 's opening weekend in limited release , it grossed $ 1.8 million , putting it in 12th place at the box office .. As of February 2010 , the film had grossed over $ 47 million domestically , ranking no. 65 for 2009 , recouping its $ 10 million budget , and making it a box office success.Precious '' received six Academy Award nominations , including one for Best Picture , at the 82nd Academy Awards .. Best Picture. Academy Award for Best Picture. 82nd Academy Awards. 82nd Academy Awards. Geoffrey Fletcher won for Best Adapted Screenplay .. Best Adapted Screenplay. Academy Award for Best Writing ( Adapted Screenplay ). Mo'Nique won the award for Best Supporting Actress , for which she received a standing ovation at the ceremony , along with numerous other accolades .. Mo'Nique. Mo'Nique. Best Supporting Actress. Academy Award for Best Supporting Actress. standing ovation. standing ovation Answer: reel
A:Stanley Kubrick was born in the thirties. B:Stanley Kubrick -LRB- -LSB- ˈkuːbrɪk -RSB- July 26 , 1928 -- March 7 , 1999 -RRB- was an American film director , screenwriter , producer , cinematographer , editor , and photographer .. cinematographer. cinematographer. editor. film editing. He is frequently cited as one of the greatest and most influential directors in cinematic history .. His films , which are mostly adaptations of novels or short stories , cover a wide range of genres , and are noted for their realism , dark humor , unique cinematography , extensive set designs , and evocative use of music .. realism. realism ( art movement ). Kubrick was born and raised in the Bronx , New York City , and attended William Howard Taft High School from 1941 to 1945 .. the Bronx. the Bronx. William Howard Taft High School. William Howard Taft High School ( New York City ). Although he only received average grades , Kubrick displayed a keen interest in literature , photography , and film from a young age , and taught himself all aspects of film production and directing after graduating from high school .. After working as a photographer for Look magazine in the late 1940s and early 1950s , he began making short films on a shoestring budget , and made his first major Hollywood film , The Killing , for United Artists in 1956 .. Look. Look ( American magazine ). The Killing. The Killing ( film ). United Artists. United Artists. This was followed by two collaborations with Kirk Douglas , the war picture Paths of Glory -LRB- 1957 -RRB- and the historical epic Spartacus -LRB- 1960 -RRB- .. Kirk Douglas. Kirk Douglas. Paths of Glory. Paths of Glory. Spartacus. Spartacus ( film ). His reputation as a filmmaker in Hollywood grew , and he was approached by Marlon Brando to film what would become One-Eyed Jacks -LRB- 1961 -RRB- , though Brando eventually decided to direct it himself .. Marlon Brando. Marlon Brando. One-Eyed Jacks. One-Eyed Jacks. Creative differences arising from his work with Douglas and the film studios , a dislike of Hollywood , and a growing concern about crime in America prompted Kubrick to move to the United Kingdom in 1961 , where he spent most of the remainder of his life and career .. His home at Childwickbury Manor in Hertfordshire , which he shared with his wife Christiane , became his workplace , where he did his writing , research , editing , and management of production details .. Childwickbury Manor. Childwickbury Manor. Hertfordshire. Hertfordshire. Christiane. Christiane Kubrick. This allowed him to have almost complete artistic control over his films , but with the rare advantage of having financial support from major Hollywood studios .. His first British productions were two films with Peter Sellers , Lolita -LRB- 1962 -RRB- and Dr. Strangelove -LRB- 1964 -RRB- .. Peter Sellers. Peter Sellers. Lolita. Lolita ( 1962 film ). Dr. Strangelove. Dr. Strangelove. A demanding perfectionist , Kubrick assumed control over most aspects of the filmmaking process , from direction and writing to editing , and took painstaking care with researching his films and staging scenes , working in close coordination with his actors and other collaborators .. filmmaking. filmmaking. He often asked for several dozen retakes of the same scene in a movie , which resulted in many conflicts with his casts .. Despite the resulting notoriety among actors , many of Kubrick 's films broke new ground in cinematography .. The scientific realism and innovative special effects of 2001  : A Space Odyssey -LRB- 1968 -RRB- were without precedent in the history of cinema , and the film earned him his only personal Oscar , for Best Visual Effects .. realism. realism ( art movement ). Visual Effects. Academy Award for Visual Effects. Steven Spielberg has referred to the film as his generation 's `` big bang '' , and it is regarded as one of the greatest films ever made .. Steven Spielberg. Steven Spielberg. the greatest films ever made. List of films considered the best. For the 18th-century period film Barry Lyndon -LRB- 1975 -RRB- , Kubrick obtained lenses developed by Zeiss for NASA , to film scenes under natural candlelight .. Barry Lyndon. Barry Lyndon. NASA. NASA. With The Shining -LRB- 1980 -RRB- , he became one of the first directors to make use of a Steadicam for stabilized and fluid tracking shots .. The Shining. The Shining ( film ). Steadicam. Steadicam. While many of Kubrick 's films were controversial and initially received mixed reviews upon release -- particularly A Clockwork Orange -LRB- 1971 -RRB- , which Kubrick pulled from circulation in the UK following a mass media frenzy -- most were nominated for Oscars , Golden Globes , or BAFTA Awards , and underwent critical reevaluations .. A Clockwork Orange. A Clockwork Orange ( film ). Oscars. Academy Award. Golden Globes. Golden Globe Award. BAFTA. British Academy of Film and Television Arts. His last film , Eyes Wide Shut , was completed shortly before his death in 1999 at the age of 70 .. Eyes Wide Shut. Eyes Wide Shut Answer: reel
A:The Great Debaters only has a brief cameo by Forest Whitaker. B:The Inter-Services Intelligence -LRB- ISI -RRB- , intelligence agency of Pakistan has been involved in running military intelligence programs in India , with one of the subsections of its Joint Intelligence Bureau -LRB- JIB -RRB- department devoted to perform various operations in India .. Inter-Services Intelligence. Inter-Services Intelligence. Pakistan. Pakistan. military intelligence. military intelligence. Intelligence Bureau. Intelligence Bureau ( India ). The Joint Signal Intelligence Bureau -LRB- JSIB -RRB- department has been also supporting Kashmiri militants in regards to communication .. Intelligence Bureau. Intelligence Bureau ( India ). The Joint Intelligence North section of the Joint Counter-Intelligence Bureau -LRB- JCIB -RRB- wing deals particularly with India .. Intelligence Bureau. Intelligence Bureau ( India ). In the 1950s the ISI 's Covert Action Division supplied arms to insurgents in Northeast India .. insurgents in Northeast India. Insurgency in Northeast India. India has also accused the ISI of reinvigorating terrorism in the country via support to pro-Khalistan militant groups such as the International Sikh Youth Federation -LRB- ISYF -RRB- , in order to take revenge against India for its help in the liberation of Bangladesh as well as to destabilize the Indian State .. pro-Khalistan. pro-Khalistan. International Sikh Youth Federation. International Sikh Youth Federation. liberation of Bangladesh. liberation of Bangladesh. A report by India 's Intelligence Bureau -LRB- IB -RRB- indicated that ISI was `` desperately trying to revive Sikh '' militant activity in India .. Intelligence Bureau. Intelligence Bureau ( India ). The ISI is also allegedly active in printing and supplying counterfeit Indian rupee notes .. counterfeit. Counterfeit money. Indian rupee. Indian rupee Answer: assessments
A:Glee was a comedy TV series. B:Lorraine Bowen -LRB- born 31 October 1961 -RRB- is an English singer , songwriter , comedian and musician .. English. English people. Born in Cheltenham , Bowen was brought up in Chelmsford , Essex .. Cheltenham. Cheltenham. Chelmsford. Chelmsford. Essex. Essex Answer: assessments
A:Margaret Brown was born in 1868. B:The 1947 -- 48 Civil War in Mandatory Palestine was the first phase of the 1948 Palestine war .. Mandatory Palestine. Mandatory Palestine. 1948 Palestine war. 1948 Palestine war. Palestine. Palestine ( region ). It broke out after the General Assembly of the United Nations adopted a resolution on 29 November 1947 recommending the adoption of the Partition Plan for Palestine .. General Assembly. United Nations General Assembly. United Nations. United Nations. Partition Plan for Palestine. United Nations Partition Plan for Palestine. Palestine. Palestine ( region ). During the civil war , the Jewish and Arab communities of Palestine clashed -LRB- the latter supported by the Arab Liberation Army -RRB- while the British , who had the obligation to maintain order , organized their withdrawal and intervened only on an occasional basis .. Arab Liberation Army. Arab Liberation Army. Jewish. Yishuv. Arab communities. Arabs. Palestine. Palestine ( region ). When the British Mandate of Palestine expired on 14 May 1948 , and with the Declaration of the Establishment of the State of Israel , the surrounding Arab states , Egypt , Transjordan , Iraq and Syria invaded what had just ceased to be Mandatory Palestine , and immediately attacked Israeli forces and several Jewish settlements .. Mandatory Palestine. Mandatory Palestine. Transjordan. Jordan. Jewish. Yishuv. Palestine. Palestine ( region ). British Mandate of Palestine. Mandatory Palestine. Declaration of the Establishment of the State of Israel. Israeli Declaration of Independence. Egypt. Kingdom of Egypt. Iraq. Kingdom of Iraq. Syria. Syrian Republic ( 1930–58 ). The conflict then turned into the 1948 Arab -- Israeli War . Answer: assessments
A:Born Naked is an album by RauPaul. B:The Loom is a Brooklyn-based indie rock band .. Brooklyn. Brooklyn. indie rock. indie rock. Formed in New York City in 2006 , the band consists of members playing a variety of instruments including guitars , mandolin , French horn , trumpet , banjo , ukulele , percussion , keyboards , and male / female vocals .. New York. New York ( state ). The band released their debut EP `` At Last Light '' in 2008 and subsequently went on tour and played Pop Montreal and CMJ Music Festivals .. extended play. Pop Montreal. Pop Montreal. CMJ. CMJ. In early 2010 they completed their first full-length album entitled `` Teeth '' , recorded at Maverick Studios in Chinatown , New York , with producer Allen Farmelo and mastered at Masterdisk Studios , with album artwork by Asthmatic Kitty artist DM Stith .. New York. New York ( state ). DM Stith. DM Stith. The Loom played 8 shows at SXSW Music Fest 2010 , including the Muzzle of Bees Backyard Barbecue with Rural Alberta Advantage , The Love Language , and others .. SXSW. SXSW. They were featured in Paste Magazine 's `` Best of What 's Next '' , and of their live show The New Yorker said , `` The beloved Loom ... have lately been guiding their chamber-folk sound to decidedly louder sonic territory . ''. Paste Magazine. Paste Magazine. The New Yorker. The New Yorker. In summer and fall of 2010 they toured the Midwest , east coast , and southern US as well as Canada , including CMJ and SXSW Music Festivals .. CMJ. CMJ. SXSW. SXSW. They were called `` The Next Big Thing '' by the New York Times .. New York. New York ( state ). New York Times. New York Times. The Loom released their first full-length album , `` Teeth '' , on November 1 , 2011 on Crossbill Records .. The single `` For the Hooves that Gallop , And the Heels that March '' debuted on NPR with their first music video .. The Loom went on an album release tour in fall 2011 in the eastern half of the US , and they are continuing to tour in spring 2012 including the west coast and SXSW as well as other music festivals .. SXSW. SXSW. In December 2011 , they released a cover of the popular New Year 's Eve song Auld Lang Syne , which was featured on The A.V. Club .. Auld Lang Syne. Auld Lang Syne. The A.V. Club. The A.V. Club Answer: assessments
A:Beastie Boys released their first EP in 1982. B:The Beastie Boys were an American hip hop group from New York City , formed in 1981 .. New York City. New York City. hip hop. hip hop music. For the majority of their career , the group consisted of Michael `` Mike D '' Diamond -LRB- vocals , drums -RRB- , Adam `` MCA '' Yauch -LRB- vocals , bass -RRB- and Adam `` Ad-Rock '' Horovitz -LRB- vocals , guitar -RRB- .. Ad-Rock. Ad-Rock. MCA. Adam Yauch. Mike D. Mike D. Originally formed as a four-piece hardcore punk band , the Young Aborigines , in 1978 by Diamond -LRB- vocals -RRB- , John Berry -LRB- guitar -RRB- , Yauch -LRB- bass -RRB- and Kate Schellenbach -LRB- drums -RRB- , the band appeared on the compilation cassette New York Thrash , before recording their first EP , Polly Wog Stew , in 1982 .. hardcore punk. hardcore punk. Kate Schellenbach. Kate Schellenbach. New York Thrash. New York Thrash. extended play. Polly Wog Stew. Polly Wog Stew. Berry left shortly thereafter , and was replaced by Horovitz .. After achieving moderate local success with the 1983 experimental hip hop 12-inch `` Cooky Puss '' , Schellenbach dropped out and the Beastie Boys made a full transition to hip hop , releasing a string of successful singles .. hip hop. hip hop music. experimental hip hop. experimental hip hop. 12-inch. 12. Cooky Puss. Cooky Puss. singles. singles ( music ). They toured with Madonna in 1985 and a year later released their debut album Licensed to Ill. .. Madonna. Madonna ( entertainer ). Licensed to Ill. Licensed to Ill. The group sold 26 million albums in the United States and 50 million albums worldwide , making them , according to Billboard , the biggest-selling rap group since the magazine began recording sales data in 1991 .. Billboard. Billboard ( magazine ). With seven platinum or better albums from 1986 to 2004 , the Beastie Boys were one of the longest-lived hip hop acts worldwide .. hip hop. hip hop music. platinum. Music recording sales certification. In 2009 , they released digitally remastered deluxe editions of their albums Paul 's Boutique , Check Your Head , Ill Communication and Hello Nasty .. Check Your Head. Check Your Head. Ill Communication. Ill Communication. Hello Nasty. Hello Nasty. Their eighth studio album , Hot Sauce Committee Part Two , was released in 2011 , and received positive reviews .. Hot Sauce Committee Part Two. Hot Sauce Committee Part Two. They were inducted into the Rock and Roll Hall of Fame in April 2012 , `` just the third rap group to enter the Hall , after Run -- D.M.C. -LRB- 2009 -RRB- and Grandmaster Flash and the Furious Five -LRB- 2007 -RRB- . ''. Rock and Roll Hall of Fame. Rock and Roll Hall of Fame. Grandmaster Flash and the Furious Five. Grandmaster Flash and the Furious Five. The following month , MCA died of cancer of the parotid salivary gland .. MCA. Adam Yauch. cancer. cancer. parotid salivary gland. parotid gland. In June 2014 , Mike D confirmed that he and Ad-Rock would not continue the Beastie Boys , out of respect to MCA .. Ad-Rock. Ad-Rock. MCA. Adam Yauch. Mike D. Mike D Answer: reel
A:Richard Nixon ran for prime minister in 1968. B:Helen Lee is a Chinese fashion designer creating for her eponymous brand Helen Lee and her streetwear brand insh .. Following her graduation from the Raffles design institute and two years working in Japan , Helen Lee returned to Shanghai to found insh -LRB- meaning `` in Shanghai '' -RRB- .. `` When I started my insh label in 2003 , 99 per cent of customers were international , maybe it 's because my style , designs and presentation were very international .. It was something new for locals , even though we used some Chinese elements ... -LSB- especially -RSB- Chinese concept and attitude .. But locals did n't have the confidence to try it back then . ''. - Helen lee said in her interview for South China Morning Post .. However , slowly but steadily , Chinese consumers influenced by social media , Internet expansion and European and American style , were opening up to local designers.insh playful and edgy pieces won the likes of both local and international customers .. The success of insh led to the creation of Helen Lee , a premium brand known for its sophisticated and edgy designs , in 2009 .. In 2010 Helen Lee had its flagship store opened on Fumin Road in the Shanghai French Concession , marking the beginning of a new chapter in high-end Chinese fashion .. Shanghai French Concession. Shanghai French Concession. Known and loved for its edgy designs and unique signature prints created for every new collection , Helen Lee is now a synonym of Shanghai fashion .. Helen Lee has collaborated on numerous fashion projects with brands like Saint James and Perfect Moment .. Currently , Helen Lee is one of the few Chinese brands stocked by multi-brand retailer Lane Crawford in China and Hong Kong and David Jones in Australia .. Lane Crawford. Lane Crawford. David Jones. David Jones Limited. Operating two brand outlets in Shanghai , the brand is also represented by a number of buyer boutiques throughout China and internationally . Answer:
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