With no explanation, label text_A→text_B with either "not_related" or "related".
text_A: Hypothyroidism can prevent a feeling of tiredness.
text_B: Local hormones , by one definition , are biologically active polypeptides that are secreted by nerve cells and gland cells and act in a paracrine fashion but also enter the circulary another definition , local hormones are any hormones acting in a paracrine , autocrine , and / or intracrine manner .. nerve. nerve. gland. gland. paracrine. paracrine. circulary. Circulation ( physiology ). autocrine. autocrine signalling. intracrine. intracrine
not_related.