[RESULTS] In patients with a listed medical history of hypertension ( n = 1,464 ) , least-squares mean ( LSM [ standard error ( SE ) ] ) changes from baseline to endpoint with placebo , tapentadol ER , and oxycodone HCl controlled release ( CR ) , respectively , were -0.7 ( 0.44 ) , 0.2 ( 0.43 ) , and -0.9 ( 0.45 ) beats per minute ( bpm ) for heart rate ; -2.4 ( 0.64 ) , -2.7 ( 0.64 ) , and -3.7 ( 0.67 ) mmHg for SBP ; and -1.0 ( 0.39 ) , -1.3 ( 0.39 ) , and -2.3 ( 0.41 ) mmHg for DBP ; in patients with at least one listed concomitant antihypertensive medication ( n = 1,376 ) , the LSM ( SE ) changes from baseline to endpoint were -0.6 ( 0.45 ) , 0.1 ( 0.44 ) , and -0.7 ( 0.47 ) bpm for heart rate ; -1.8 ( 0.66 ) , -3.3 ( 0.65 ) , and -3.7 ( 0.69 ) mmHg for SBP ; and -0.7 ( 0.40 ) , -1.4 ( 0.40 ) , and -2.3 ( 0.42 ) mmHg for DBP .