[RESULTS] On week 12 , the mean ( SD ) change in total Kupperman index score ( -9.23 [ 6.23 ] ) from baseline to week 12 ; the mean ( SD ) changes in individual scores for paresthesia ( -1.08 [ 1.51 ] ) , insomnia ( -1.00 [ 1.46 ] ) , irritability ( -1.00 [ 1.34 ] ) , joint or muscle pain ( -0.75 [ 0.74 ] ) , fatigue ( -0.56 [ 0.75 ] ) , headache ( -0.54 [ 0.75 ] ) , formication ( -0.38 [ 0.66 ] ) , and sexual life ( -0.62 [ 1.71 ] ) ; and the mean ( SD ) changes in total cholesterol ( -0.76 [ 0.63 ] mmol/L ) and triglycerides ( -0.20 [ 0.50 ] mmol/L ) were significantly higher in the intervention group than in the control group ( P < 0.05 ) .