[METHODS] Blood samples were drawn before and 2 , 4 , 6 and 8 h after induction of endotoxaemia and plasma was tested for pro-inflammatory markers ( tumor necrosis factor alpha , TNF - , interleukin-1 , IL-1 , interleukin-1 , IL-6 , and YKL-40 ) , anti-inflammatory markers ( interleukin-1 receptor antagonist , IL-1Ra , interleukin-10 , IL-10 , soluble tumor necrosis factor receptors I and II , sTNF-RI and sTNF-RII ) , marker for oxidative damage ( malondialdehyde ( MDA ) ) and antioxidative enzyme ( ascorbic acid ( AA ) and dehydroascorbic acid ( DHA ) ) .