[METHODS] In the observation group , besides the physician instruction of low protein and low phosphorus diet in the two groups , Guan 's quadruple therapy for kidney disease was applied , including ( 1 ) the isolated herbal moxibustion at Shenshu ( BL 23 ) and Pishu ( BL 21 ) , or Ganshu ( BL 18 ) , Zusanli ( ST 36 ) and Guanyuan ( CV 4 ) alternatively ; ( 2 ) acupuncture at the auricular points such as shen ( CO10 ) , jiaogan ( AHR6 ) , Shenshangxian ( TG2 ) , fei ( CO14 ) and pizhixia ( AT4 ) ; ( 3 ) injection of mixture of astragalus injection and lidocaine injection at Feishu ( BL 13 ) , Pishu ( BL 21 ) , Shenshu ( BL 23 ) and the others ; ( 4 ) modified Shenshuai Yihao decoction according to syndrome differentiation .