[RESULTS] ( 1 ) No significant between-group difference of age , gender , smoking , previous glucocorticoid use and hemoglobin level was found ; ( 2 ) after 10.60.8 d of PPI therapy , BMD T score in the controlled group was slightly increased compared with initial ( -1.250.08 versus -1.280.06 , p = 0.084 ) , while there was no change in the supplemented group ( -1.250.05 versus -1.260.03 , p = 0.308 ) ; ( 3 ) during study termination , calcium level in the supplemented group was slightly higher than the controlled group ( 2.050.03 mmol/L versus 2.010.05 mmol/L , p = 0.073 ) , while no significant differences of CTX ( 366.5743.71 pg/mL versus 373.1550.23 pg/mL , p = 0.036 ) and ALP were found among these two groups ( 50.479.32 U/L versus 52.2310.45 U/L , p = 0.075 ) .