[METHODS] Percentages of remitters ( ie , a score of 7 in the 17-item Hamilton Depression Rating Scale [ HDRS-17 ] ) and HDRS-17 score changes from baseline to week 6 were compared in the following 2 pairs , using Fisher exact test or mixed-effects model for repeated measures : ( 1 ) subjects who failed to show a 20 % decrease in the HDRS-17 total scores at week 1 but were assigned to continue 15 mg/d ( stay ( 15 ) group ) versus those who were assigned to increase the dose to 30 mg/d ( increase ( 30 ) group ) and ( 2 ) subjects who failed to show a 20 % decrease in the HDRS-17 total scores with 30 mg/d at week 2 but were assigned to continue 30 mg/d ( stay ( 30 ) group ) versus those who were assigned to increase the dose to 45 mg/d ( increase ( 45 ) group ) .