[RESULTS] In both studies , we noted improvements in trough FEV1 on day 169 for both doses of UMEC plus VI compared with TIO monotherapy ( study 1 , UMEC 125 g plus VI 25 g : 0088 L [ 95 % CI 0036 to 0140 ; p = 00010 ] ; study 1 , UMEC 625 g plus VI 25 g : 0090 L [ 0039 to 0141 ; p = 00006 ] ; study 2 , UMEC 125 g plus VI 25 g : 0074 L [ 0025 to 0123 ; p = 00031 ] ; study 2 , UMEC 625 g plus VI 25 g : 0060 L [ 0010 to 0109 ; nominal p = 00182 ] ) .