Source: http://www.google.com/patents/US8244371?dq=inassignee:google
Timestamp: 2015-05-06 22:44:00
Document Index: 687463789

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'art, 15', 'Application No. 99931435', 'Application No. 06759102', 'Application No. 05853465', 'Application No. 07110023', 'Application No. 03794043', 'Application No. 04106247', 'Application No. 05853465', 'Application No. 97929478', 'Application No. 06759102', 'Application No. 1161', 'Application No. 212', 'Application No. 04719312', 'Application No. 2004', 'Application No. 200480027293', 'Application No. 200480012687', 'Application No. 03824661', 'Application No. 200480012687', 'Application No. 200480012687', 'Application No. 200480027083', 'Application No. 03824661', 'Application No. 2004800009336', 'Application No. 200480012687', 'Application No. 03824661', 'Application No. 128955', 'Application No. 97929478', 'Application No. 2006', 'Application No. 04770468', 'Application No. 10', 'Application No. 09', 'Application No. 05853465', 'Application No. 200480012687', 'Application No. 04719312', 'Application No. 533', 'Application No. 2007', 'Application No. 07110023', 'Application No. 200480012687', 'Application No. 09', 'Application No. 200480012687', 'Application No. 533', 'Application No. 97929480', 'Application No. 006759102', 'Application No. 05853465', 'Application No. 04770468', 'Application No. 04719312', 'Application No. 2004', 'Application No. 2007', 'Application No. 09', 'Application No. 9', 'Application No. 2006', 'Application No. 200480012687', 'Application No. 200480012687', 'Application No. 200480032636']

Patent US8244371 - Pancreas lead - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsAn implant device comprising an electrode for electrical stimulation of the pancreas, the device being adapted to be inserted into the pancreas, and to change at least one of its properties after being inserted into the pancreas, so that it will cause less irritation to the pancreas than before changing...http://www.google.com/patents/US8244371?utm_source=gb-gplus-sharePatent US8244371 - Pancreas leadAdvanced Patent SearchPublication numberUS8244371 B2Publication typeGrantApplication numberUS 11/886,154PCT numberPCT/IL2006/000345Publication dateAug 14, 2012Filing dateMar 16, 2006Priority dateMar 18, 2005Also published asUS20090062893, WO2006097934A2, WO2006097934A3Publication number11886154, 886154, PCT/2006/345, PCT/IL/2006/000345, PCT/IL/2006/00345, PCT/IL/6/000345, PCT/IL/6/00345, PCT/IL2006/000345, PCT/IL2006/00345, PCT/IL2006000345, PCT/IL200600345, PCT/IL6/000345, PCT/IL6/00345, PCT/IL6000345, PCT/IL600345, US 8244371 B2, US 8244371B2, US-B2-8244371, US8244371 B2, US8244371B2InventorsPaul Richard Spehr, Tamir Levi, Benny RoussoOriginal AssigneeMetacure LimitedExport CitationBiBTeX, EndNote, RefManPatent Citations (99), Non-Patent Citations (473), Referenced by (2), Classifications (15), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetPancreas lead
US 8244371 B2Abstract
1. An implant device comprising an electrode for electrical stimulation of an in-vivo soft tissue, the device being adapted to be inserted into the tissue, and to change at least one said device's properties after being inserted into the tissue for allowing said electrode to longitudinally deform for conforming to any one of a change in shape, position, or orientation in the tissue so that it will cause less irritation to the tissue than before changing said property;
wherein said longitudinal deforming is by at least 20% of a length of said electrode.
2. An implant device according to claim 1, comprising an inserting element adapted to assist the device in being inserted into the tissue, wherein the device is adapted to become mechanically decoupled from the inserting element after the device is inserted into the tissue.
3. An implant device according to claim 2, adapted to have the inserting element removed from the tissue after the device is inserted into the tissue.
4. An implant device according to claim 2, wherein the inserting element comprises a needle which is adapted to go through the tissue and to pull the electrode into the tissue.
11. An implant device according to claim 1, including a mechanical sleeve surrounding the electrode, adapted to be sufficiently well electrically coupled to the electrode and to the tissue for electrical stimulation therapy of the tissue by the electrode, when the device is inserted into the tissue.
12. An implant device according to claim 11, wherein the sleeve is adapted to become better coupled mechanically to the tissue after the device is inserted into the tissue.
13. An implant device according to claim 12, wherein the sleeve comprises one or more tines adapted to become set in the tissue.
14. An implant device according to claim 12, wherein the sleeve is adapted to expand inside the tissue, thereby increasing its mechanical coupling to the tissue.
15. An implant device according to claim 12, wherein the sleeve is adapted to become glued to the tissue after the device is inserted into the tissue.
16. An implant device according to claim 11, wherein the sleeve is adapted to become mechanically less coupled from the electrode after the device is inserted into the tissue.
17. An implant device according to claim 11, wherein the sleeve is sufficiently soft so that it causes less irritation to the tissue than the electrode would cause if the electrode were directly in contact with the interior of the tissue without a sleeve.
18. An implant device according to claim 1, adapted to become one or both of softer and more flexible after the device is inserted into the tissue.
19. An implant device according to claim 18, comprising a coating of a hard material adapted to dissolve inside the tissue.
23. An implant device according to claim 1, also including a lead for supplying current to the electrode, the lead being adapted to being anchored at an anchoring point inside the body, and being sufficiently long and flexible so that a one centimeter increase in distance between the anchoring point and the implanted electrode causes the lead to exert a force no greater than 0.01 newtons on the tissue.
24. An implant device according to claim 1, also including tines coupled to the electrode, oriented so as to prevent the electrode from moving back out of the tissue after the electrode is implanted in the tissue.
26. An implant device according to claim 1 including a lead for supplying current to said electrode, and wherein said lead is flexibly attached to said electrode.
27. An implant device according to claim 26 wherein at least a portion of said lead is a helical coil.
28. An implant device according to claim 1 wherein said tissue is an abdominal tissue.
29. An implant device according to claim 1 wherein said tissue is the pancreas. Description
This Application is a National Phase of PCT Patent Application No. PCT/IL2006/000345 having International Filing Date of Mar. 16, 2006, which is a Continuation-In-Part of PCT Patent Application No. PCT/IL2005/000316 filed on Mar. 18, 2005, and claims the benefit of U.S. Provisional Patent Application No. 60/719,517 filed on Sep. 22, 2005 and U.S. Provisional Patent Application No. 60/719,421 filed on Sep. 22, 2005. The contents of the above Applications are all incorporated herein by reference.
a) an electrode for electrical stimulation of the pancreas; and b) a sleeve, through which the electrode is electrically coupled to the pancreas with a resistance less than 20 ohms. Optionally, the sleeve is one or both of sufficiently soft and sufficiently well-coupled mechanically to the pancreas so that the sleeve causes less irritation to the pancreas than the electrode would if the electrode were directly in contact with the interior of the pancreas without a sleeve.
a) inserting the device into the pancreas; and b) changing at least one property of the device after inserting it into the pancreas, so that it causes less irritation to the pancreas. BRIEF DESCRIPTION OF THE DRAWINGS
The helical form of electrode 106 also makes it sufficiently flexible and stretchable that it will tend not to irritate the pancreas, since it can move, bend, and stretch, conforming to changes in the position, orientation and shape of the pancreas, without exerting much force on the surrounding pancreatic tissue. For example, electrode 106 can stretch in length by at least 20% without the material exceeding its infinite-cycle strain limit. As an example of a design for electrode 106 which satisfies these criteria, the electrode is made of grade 2, cold-worked titanium wire, 0.03 mm in diameter, wrapped into a helix with 4 wires in parallel, 0.50 mm in outer diameter, 0.44 mm in inner diameter, and 10 mm in length, with a pitch of 0.15 mm, so there are 66.7 turns. The longitudinal spring constant for this design is 0.0026 N/mm, and the bending stiffness is 3.6�10−5 N-mm/radian. The resistance of each wire is 18 ohms, so the resistance of the 4 wires in parallel is 4.5 ohms. Alternatively, any of the dimensions is greater or less than these numbers, for example by up to 25%, or by up to 50%, or more, and any other bio-compatible metal is used.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS1918386Dec 26, 1928Jul 18, 1933Abraham EsauApparatus for diathermic treatment by means of high frequencyUS3211154Jun 25, 1962Oct 12, 1965Mine Safety Appliances CoSequence switch for ventricular defibrillatorUS3541390Apr 29, 1968Nov 17, 1970Berckheim Graf VonSteady-field generating arrangementUS3572345Jan 27, 1969Mar 23, 1971Philips CorpStrap for a heart stimulatorUS3587567Dec 20, 1968Jun 28, 1971Schiff Peter PaulMechanical ventricular assistance assemblyUS3651805May 7, 1970Mar 28, 1972Draegerwerk AgAnesthetic vaporizerUS3651806Oct 24, 1969Mar 28, 1972Philip I HirshbergMethod and apparatus for administering digitalizing medicationsUS3796221Jul 7, 1971Mar 12, 1974Hagfors NApparatus for delivering electrical stimulation energy to body-implanted apparatus with signal-receiving meansUS3911930Mar 1, 1974Oct 14, 1975Stimulation TechMethod and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulationUS3924641Aug 19, 1974Dec 9, 1975Axotronics IncBi-phasic current stimulation systemUS3933147Apr 2, 1970Jan 20, 1976Vall Wilbur E DuApparatus and method for treating disorders in the region of the pubococcygeous muscleUS3942536Sep 19, 1973Mar 9, 1976Mieczyslaw MirowskiCardioverting device having single intravascular catheter electrode system and method for its useUS3944740Jul 22, 1974Mar 16, 1976Fujitsu LimitedCoordinate position information output deviceUS3952750Apr 25, 1974Apr 27, 1976Mieczyslaw MirowskiCommand atrial cardioverting deviceUS4030509Sep 30, 1975Jun 21, 1977Mieczyslaw MirowskiImplantable electrodes for accomplishing ventricular defibrillation and pacing and method of electrode implantation and utilizationUS4055190Dec 19, 1974Oct 25, 1977Michio TanyElectrical therapeutic apparatusUS4106494Aug 29, 1977Aug 15, 1978American Optical CorporationHeart defibrillating and monitoring systemUS4164216Jan 26, 1978Aug 14, 1979Person Orville WThroat obstruction expulsion deviceUS4168711Jun 8, 1978Sep 25, 1979American Optical CorporationReversal protection for RLC defibrillatorUS4184493Feb 15, 1978Jan 22, 1980Mieczyslaw MirowskiCircuit for monitoring a heart and for effecting cardioversion of a needy heartUS4202340Feb 15, 1978May 13, 1980Mieczyslaw MirowskiMethod and apparatus for monitoring heart activity, detecting abnormalities, and cardioverting a malfunctioning heartUS4223678May 3, 1978Sep 23, 1980Mieczyslaw MirowskiArrhythmia recorder for use with an implantable defibrillatorUS4237895Apr 20, 1979Dec 9, 1980Medcor, Inc.Control signal transmitter and monitor for implanted pacerUS4273114Nov 23, 1979Jun 16, 1981Michigan Instruments, Inc.Cardiopulmonary resuscitator, defibrillator and monitorUS4293734Feb 23, 1979Oct 6, 1981Peptek, IncorporatedTouch panel system and methodUS4312354Feb 4, 1980Jan 26, 1982Arco Medical Products CompanyPacemaker with circuit for pulse width modulating stimulus pulses in accordance with programmed parameter control statesUS4315503Dec 5, 1979Feb 16, 1982Electro-Biology, Inc.Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environmentUS4316472Aug 9, 1979Feb 23, 1982Mieczyslaw MirowskiCardioverting device with stored energy selecting means and discharge initiating means, and related methodUS4337776Aug 29, 1980Jul 6, 1982Telectronics Pty. Ltd.Impedance measuring pacerUS4369791Apr 13, 1981Jan 25, 1983Medtronic, Inc.Body implantable electrodeUS4384585Mar 6, 1981May 24, 1983Medtronic, Inc.Synchronous intracardiac cardioverterUS4387717Oct 3, 1980Jun 14, 1983Research CorporationPacer internal cardiac electrogram sensing systemUS4403614Feb 27, 1981Sep 13, 1983Medtronic, Inc.Implantable cardioverterUS4406288Apr 6, 1981Sep 27, 1983Hugh P. CashBladder control device and methodUS4407288Mar 16, 1981Oct 4, 1983Mieczyslaw MirowskiImplantable heart stimulator and stimulation methodUS4411268Feb 10, 1982Oct 25, 1983Medtronic, Inc.Muscle stimulatorUS4428366May 6, 1981Jan 31, 1984Alfred B. KurtzElectromagnetic apparatus and method for the reduction of serum glucose levelsUS4440172Dec 11, 1980Apr 3, 1984Mieczyslaw MirowskiApparatus for combining pacing and cardioverting functions in a single implanted deviceUS4506680Mar 17, 1983Mar 26, 1985Medtronic, Inc.Drug dispensing body implantable leadUS4537195Nov 20, 1981Aug 27, 1985Mcdonnell Roy EElectrical control of body discharges and headachesUS4537203Jun 25, 1984Aug 27, 1985Tokyo Shibaura Denki Kabushiki KaishaAbnormal cell detecting deviceUS4543738Mar 30, 1982Oct 1, 1985Mower Morton MSki boot for concentrating a skier's weight on a ski edgeUS4543956May 24, 1984Oct 1, 1985Cordis CorporationBiphasic cardiac pacerUS4550221Oct 7, 1983Oct 29, 1985Scott MabusthTouch sensitive control deviceUS4554922Sep 30, 1982Nov 26, 1985Prystowsky Eric NMethod of inhibiting cardiac arrhythmiasUS4554992Sep 9, 1983Nov 26, 1985Fmc CorporationHydraulically operated four wheel sweeperUS4559946Jun 18, 1982Dec 24, 1985Mieczyslaw MirowskiMethod and apparatus for correcting abnormal cardiac activity by low energy shocksUS4559947Jan 27, 1984Dec 24, 1985Renger Herman LCardiac tissue stimulator providing P-wave verification, telemetry, marker channels, and antitachycardia capabilitiesUS4566456Oct 18, 1984Jan 28, 1986Cordis CorporationApparatus and method for adjusting heart/pacer rate relative to right ventricular systolic pressure to obtain a required cardiac outputUS4572191Feb 23, 1984Feb 25, 1986Mieczyslaw MirowskiCommand atrial cardioverterUS4628934Aug 7, 1984Dec 16, 1986Cordis CorporationMethod and means of electrode selection for pacemaker with multielectrode leadsUS4637397May 30, 1985Jan 20, 1987Case Western Reserve UniversityTriphasic wave defibrillationUS4639720Jan 12, 1981Jan 27, 1987Harris CorporationElectronic sketch padUS4651716Nov 1, 1985Mar 24, 1987Canadian Patents And Development LimitedMethod and device for enhancement of cardiac contractilityUS4674508May 28, 1985Jun 23, 1987Cordis CorporationLow-power consumption cardiac pacer based on automatic verification of evoked contractionsUS4679572Mar 11, 1986Jul 14, 1987Intermedics, Inc.Low threshold cardiac pacing electrodesUS4686332Jun 26, 1986Aug 11, 1987International Business Machines CorporationCombined finger touch and stylus detection system for use on the viewing surface of a visual display deviceUS4690155Dec 24, 1986Sep 1, 1987Cordis CorporationMonophasic action potential recording leadUS4693253Mar 23, 1981Sep 15, 1987Medtronic, Inc.Automatic implantable defibrillator and pacerUS4708145Sep 11, 1985Nov 24, 1987Medtronic, Inc.Sequential-pulse, multiple pathway defibrillation methodUS4717581Nov 13, 1986Jan 5, 1988Eic Laboratories, Inc.Iridium oxide coated electrodes for neural stimulationUS4726279Nov 12, 1986Feb 23, 1988United Technologies CorporationWake stabilized supersonic combustion ram cannonUS4726379Nov 14, 1985Feb 23, 1988Cardiac Control Systems, Inc.Cardiac pacer with switching circuit for isolationUS4765341Aug 25, 1983Aug 23, 1988Mieczyslaw MirowskiCardiac electrode with attachment finUS4807632May 19, 1987Feb 28, 1989Siemens AktiengesellschaftMeasuring instrument for intracardial acquisition of the blood oxygen saturation of a patient for controlling the pacing rate of a heart pacemakerUS4830006Jun 17, 1986May 16, 1989Intermedics, Inc.Implantable cardiac stimulator for detection and treatment of ventricular arrhythmiasUS4834100May 12, 1986May 30, 1989Charms Bernard LApparatus and method of defibrillationUS4850959Aug 2, 1988Jul 25, 1989Bioresearch, Inc.Bioelectrochemical modulation of biological functions using resonant/non-resonant fields synergisticallyUS4870974Mar 31, 1988Oct 3, 1989Chinese Pla General HospitalApparatus and method for detecting heart characteristics by way of electrical stimulationUS4878553Sep 14, 1987Nov 7, 1989Wacom Co., Ltd.Position detecting apparatusUS4884576Sep 28, 1988Dec 5, 1989Eckhard AltSelf adjusting rate responsive cardiac pacemaker and methodUS4914624May 6, 1988Apr 3, 1990Dunthorn David IVirtual button for touch screenUS4928688Jan 23, 1989May 29, 1990Mieczyslaw MirowskiMethod and apparatus for treating hemodynamic disfunctionUS4967749Aug 18, 1988Nov 6, 1990Leonard BloomHemodynamically responsive system for and method of treating a malfunctioning heartUS4971058Jul 6, 1989Nov 20, 1990Ventritex, Inc.Cardiac therapy method with duration timerUS4979507May 3, 1989Dec 25, 1990Eckhard AltEnergy saving cardiac pacemakerUS4988837Apr 30, 1990Jan 29, 1991Wacom Co., Ltd.Position detecting deviceUS4996984Sep 26, 1989Mar 5, 1991Eli Lilly And CompanyDefibrillation methodUS4998531Mar 28, 1990Mar 12, 1991Cardiac Pacemakers, Inc.Implantable N-phasic defibrillator output bridge circuitUS4998532Feb 21, 1989Mar 12, 1991Lti Biomedical, Inc.Portable electro-therapy systemUS5002052Aug 29, 1988Mar 26, 1991Intermedics, Inc.System and method for detection and treatment of ventricular arrhythmiasUS5003976Sep 28, 1988Apr 2, 1991Eckhard AltCardiac and pulmonary physiological analysis via intracardiac measurements with a single sensorUS5018522Oct 26, 1987May 28, 1991Medtronic, Inc.Ramped waveform non-invasive pacemakerUS5020544Nov 1, 1989Jun 4, 1991Cardiac Pacemakers, Inc.Low energy defibrillation electrodeUS5022396Dec 12, 1989Jun 11, 1991Hideto WatanabeCatheter for simultaneously measuring monophasic action potential and endocardiac cavity pressureUS5026397Sep 10, 1990Jun 25, 1991Kabushiki Kaisya Advance Kaihatsu KenkyujoTranscutaneously implantable elementUS5031617Mar 13, 1989Jul 16, 1991Klettner Harold LMethod of altering human blood glucose levels by the application of electric chargeUS5041107Oct 6, 1989Aug 20, 1991Cardiac Pacemakers, Inc.Electrically controllable, non-occluding, body implantable drug delivery systemUS5044375Dec 8, 1989Sep 3, 1991Cardiac Pacemakers, Inc.Unitary intravascular defibrillating catheter with separate bipolar sensingUS5048522Jan 2, 1991Sep 17, 1991Therapeutic Technologies, Inc.Power muscle stimulatorUS5050612Sep 12, 1989Sep 24, 1991Matsumura Kenneth NDevice for computer-assisted monitoring of the bodyUS5063929Aug 25, 1989Nov 12, 1991Staodyn, Inc.Electronic stimulating device having timed treatment of varying intensity and method thereforUS5083564Jun 1, 1990Jan 28, 1992Board Of Regents Of The University Of OklahomaMethod for alleviating and diagnosing symptoms of heart blockUS5085218Aug 31, 1990Feb 4, 1992Cardiac Pacemakers, Inc.Bipolar myocardial positive fixation lead with improved sensing capabilityUS5087243Jun 18, 1990Feb 11, 1992Boaz AvitallMyocardial iontophoresisUS5097832Mar 9, 1990Mar 24, 1992Siemens-Pacesetter, Inc.System and method for preventing false pacemaker pvc responseUS5097833Sep 19, 1989Mar 24, 1992Campos James MTranscutaneous electrical nerve and/or muscle stimulatorUS5097843Apr 10, 1990Mar 24, 1992Siemens-Pacesetter, Inc.Porous electrode for a pacemakerUS5101814Aug 11, 1989Apr 7, 1992Palti Yoram ProfSystem for monitoring and controlling blood glucoseNon-Patent CitationsReference1Adeghate et al. "Effect of Electrical Field Stimulation on Insulin and Glucagon Secretion From the Pancreas of Normal and Diabetic Rats", Hormonal Metabolism Research, 33: 281-289, 2001.2Adeghate et al. "Effect of Electrical Field Stimulation on Insulin and Glucagon Secretion From the Pancreas of Normal and Diabetic Rats", Hormone and Metabolic Research, 33(5): 281-289, May 2001. Abstract.3Amended Request for Ex Parte Reexamination of US Patent No. 6,317,631 Dated Aug. 20, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.4Antman et al. "Treatment of 150 Cases of Life-Threatening Digitalis Intoxication With Digoxin-Specific Fab Antibody Fragments", Circulation, 81(6): 1744-1752, 1990.5Antman et al. "Treatment of 150 Cases of Life-Threatening Digitalis Intoxication With Digoxin-Specific Fab Antibody Fragments. Final Report of a Multicenter Study", Circulation, 81(6): 1744-1752, 1990.6Antoni et al. "Polarization Effects of Sinusoidal 50-Cycle Alternating Current on Membrane Potential of Mammalian Cardia Fibers", Pfl�gers Archiv, European Journal of Physiology, 314(4): 274-291, 1970. Abstract.7Antoni et al. "Polarization Effects of Sinusoidal 50-Cycle Alternating Current on Membrane Potential of Mammalian Cardiac Fibres", Pfl�gers Archiv European Journal of Physiology, 314(4): 274-291, 1970. Abstract.8Bakker et al. "Beneficial Effects of Biventricular Pacing of Congestive Heart Failure", Pace, 17(Part II): 318, 1994.9Bakker et al. "Biventricular Pacing Improves Functional Capacity in Patients With End-Stage Congestive Heart Failure", Pace, 17(11/Part II/120): 825, 1995.10Bargheer et al. "Prolongation of Monophasic Action Potential Duration and the Refractory Period in the Human Heart by Tedisamil, A New Potassium-Blocking Agent", Journal European Heart, 15(10): 1409-1414, 1994, Abstract.11Bargheer et al. "Prolongation of Monophastic Action Potantial Duration and the Refractory Period in the Human Heart by Tedisamil, A New Potassium-Blocking Agent", The European Society of Cardiology, 15(10): 1409-1414, 1994.12Bergsten et al. "Synchronous Oscillations of Cytoplasmic Ca2+ and Insulin Release in Glucose-Stimulated Pancreatic Islets", The Journal of Biological Chemistry, 269(12): 8749-8753, 1994.13Bergsten et al. "Synchronous Oscillations of Cytoplasmic Ca2+ and Insulin Release in Glucose-Stimulated Pancreatic Islets", The Journal of Biological Chemistry, 269(12): 8749-8753, Mar. 25, 1994.14Bers "Excitation Contraction Coupllng and Cardiac Contractile Force", Internal Medicine, 237(2): 17, 1991, Abstract.15Blank et al. "Initial Interactions in Electromagnetic Field-Induced Biosynthesis", Journal of Cellular Physiology, 199: 359-363, 2004.16Borst et al. "Coronary Artery Bypass Gratting Without Cardiopulomonary Bypass and Without Interuption of Native Coronary Flow Using a Novel Anastomosis Site Restraining Device (Octupus)", Journal of the American College of Cardiology, 27(6): 1356-1364, 1996.17Bouaziz et al. "Direct Electrical Stimulation of Insulin Secretion by Intact Murine Islets of Langerhans Through the Culture Support", Electromagnetic Biology and Medicine, 17(2): 171-184, 1998. Abstract.18Bronzino "Biomedical Engineering Handbook", IEEE Press/CRC Press, Chap. 82.5: 1288, 1995.19Burfeind et al "The Effects of Mechanical Cardiac Stabilization on Left Ventricular Performance", Europeari Journal of Cardio-Thoracic Surgery, 14: 285-289, 1998.20Burfeind et al. "The Effects of Mechanical Cardiac Stabilization on Left Ventricular Performance", European Journal of Cardio-Thoracic Surgery,14: 285-289, 1998.21Cano et al. "Dose-Dependent Reversal of Digoxin-Inhibited Activity of an In-Vitro Na+K+ATPase Model by Digoxin-Specific Antibody", Toxicology Letters, 85(2): 107-111, 1996. Abstract.22Cano et al. "Dose-Dependent Reversal of Dixogin-Inhibited Activity of an In-Vitro Na+K+ATPase Model by Digoxin-Specific Antibody", Toxicology Letters, 85(2): 107-1011, 1996.23Cazeau et al. "Multisite Pacing for End-Stage Heart Failure: Early Experience", Pacing and Clinical Electrophysiology, 19(11): 1748-1757, 1996, Abstract.24Cazeau et al. "Multisite Pacing for End-Stage Heart Failure: Early Experience", Pace, 19(Part II): 1748-1757, 1996.25Cheng et al. "Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle", Science, 262(5134): 740-744, 1993, Abstract.26Cheng et al. "Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle", Science, 262: 740-744, 1993.27Communication Pursuant to Article 94(3) EPC Dated Aug. 11, 2010 From the European Patent Office Re. Application No. 99931435.4.28Communication Pursuant to Article 94(3) EPC Dated Aug. 26, 2011 From the European Patent Office Re. Application No. 06759102.4.29Communication Pursuant to Article 94(3) EPC Dated Aug. 26, 2011 From the European Patent Office Re.: Application No. 05853465.2.30Communication Pursuant to Article 94(3) EPC Dated Jan. 27, 2010 From the European Patent Office Re. Application No. 07110023.4.31Communication Pursuant to Article 94(3) EPC Dated Jan. 28, 2009 From the European Patent Office Re.: Application No. 03794043.4.32Communication Pursuant to Article 94(3) EPC Dated Jan. 29, 2009 From the European Patent Office Re.: Application No. 04106247.2.33Communication Pursuant to Article 94(3) EPC Dated Mar. 2, 2009 From the European Patent Office Re.: Application No. 05853465.2.34Communication Pursuant to Article 96(2) EPC Dated Mar. 2, 2007 From the European Patent Office Re.: Application No. 97929478.2.35Communication to Pursuant to Article 94(3) EPC Dated Mar. 4, 2009 From the European Search Report Re.: Application No. 06759102.4.36Cooper "Postextrasystolic Potention. Do We Really Know What It Means and How to Use It?", Circulation, 88: 2962-2971, 1993.37Cooper "Postextrasystolic Potentiation: Do We Really Know What It Means and How to Use It?", Circulation, 88(6): 2962-2971, 1993.38Coulton et al. "Magnetic Fields and Intracellular Calcium; Effects on Lymphocytes Exposed to Conditions for 'Cyclotron Resonance'", Phys. Med. Biol., 38: 347-360, 1993, Abstract.39Coulton et al. "Magnetic Fields and Intracellular Calcium: Effects on Lymphocytes Exposed to Conditions for �Cyclotron Resonance�", Physics in Medicine and Biology, 38: 347-360, 1993.40Coulton et al. "Magnetic Fields and Intracellular Calcium; Effects on Lymphocytes Exposed to Conditions for �Cyclotron Resonance�", Phys. Med. Biol., 38: 347-360, 1993, Abstract.41Crider et al. "2-Pyridylthioureas: Novel Nonpeptide Somatostatin Agonists With SST4 Selectivity", Current Pharmaceutical Design, 5(4): 255-263, 1999.42Davis et al. "Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas", The Pharmacological Basis of Therapeutics, Chap.60: 1487-1499, 1507-1510.43Devedeux et al. "Uterine Electromyography: A Critical Review", American Journal of Obstetrics & Gynecology, 169(6): 1636-1653, 1993. Abstract.44Devedeux et al. "Uterine Electromyography: A Critical Review", American Journal of Obstetric Gynecology, 169(6): 1636-1653, 1993.45Dillion "Optial Recordings in the Rabbit Heart Show That Defibrillation Strength Shocks Prolong the Duration of Depolarization and the Refractory Period", Circulation Research, 69: 842-856, 1991.46Dillion "Optial Recordings in the Rabbit Heart Show That Defibrillation Strenght Shocks Prolong the Duration of Depolarization and the Refractory Period", Circulation Research, 69: 842-856, 1991.47Dillon "Synchronized Repolarization After Defibrillation Shocks. A Possible Component of the Defibrillation Process Demonstration by Optical Recordings in Rabbit Heart", Circulation, 85(5): 1865-1878, 1992.48Erol-Yilmaz et al. "Reversed Remodelling of Dilated Left Sided Cardiomyopathy After Upgrading From VVIR to VVIR Biventricular Pacing", Europace, 4: 445-449, 2002.49Examination Report Dated Jun. 26, 2009 From the Government of India, Patent Office Re.: Application No. 1161/CHENP/2006.50Examination Report Dated Nov. 30, 2010 From the Government of India, Patent Office Re. Application No. 212/MUMNP/2006.51Fain et al. "Improved Internal Defibrillation Efficacy With a Biphasic Waveform", American Heart Journal, 117(2): 358-364, 1989, Abstract.52Fain et al. "Improved Internal Defibrillation Efficacy With a Biphasic Waveform", American Heart Journal, 117(2): 358-364, 1989.53Fleg et al. "Impact of Age on the Cardiovasvular Response to Dynamic Upright Exercise in Healthy Men and Women", Journal of Applied Physiologyl, 78: 890-900, 1995, Abstract.54Fleg et al. "Impact of Age on the Cardiovasvular Response to Dynamic Upright Exercise in Healthy Men and Women", Journal of Applied Physiology, 78: 890-900, 1995.55Fleischhauer et al. "Electrical Resistances of Interstitial and Microvascular Space as Determinants of the Extracellular Electrical Field and Velocity of Propagation in Ventricular Myocardium", Circulation, 92: 587-594, 1995.56Foster et al. "Acute Hemodynamic Effects of Atrio-Biventricular Padng in Humans", The Society of Thoracic Surgeons, 59: 294-300, 1995, Abstract.57Foster et al. "Acute Hemodynamic Effects of Atrio�Biventricular Padng in Humans", The Society of Thoracic Surgeons, 59: 294-300, 1995, Abstract.58Foster et al. "Acute Hemodynamic Effects of Atrio�Biventricular Padng in Humans", The Society of Thoracic Surgeons, 59: 294-300, 1995.59Franz "Bridging the Gap Between Basic Clinical Electrophysiology: What Can Be Learned From Monophasic Action Potential Recordings?", Journal Cardiovasc Electrophysiology, 5(8): 699-710, 1994, Abstract.60Franz "Method and Theory of Monophasic Action Potential Recording", Prog. Cardiovasc Dis, 33(6): 347-368, 1991.61Franz "Bridging the Gap Between Basic Clinical Electrophysiology: What Can Be Learned From Monophasic Action Potential Recordings?", Journal of Cardiovascular Electrophysiology, 5(8): 699-710, 1994.62Franz "Method and Theory of Monophasic Action Potential Recording", Progress in Cardiovascular Diseases, 33(6): 347-368, 1991. Abstract.63Franz "Method and Theory of Monophasic Action Potential Recording", Progresses In Cardiovascular Diseases, 33(6): 347-368, 1991.64Fromer et al. "Ultrarapid Subthreshold Stimulation for Termination of Atriventricular Node Reentrant Tachycardia", Journal of the American College Cardiology, 20: 879-883, 1992.65Fromer et al. "Ultrarapid Subthreshold Stimulation for Termination of Atriventricular Node Reentrant Tachycardia", Journal of the American College of Cardiology, 20(4): 879-883, 1992.66Fu et al. "System Identification of Electrically Coupled Smooth Music Cells: The Passive Electrically Coupled Smooth Muscle Cells: The Passive Electrical Properties", IEEE Transactions on Biomedical Engineering, 38(11): 1130-1140, 1991.67Fu et al. "System Identification of Electrically Coupled Smooth Muscle Cells: The Passive Electrically Coupled Smooth Muscle Cells: The Passive Electrical Properties", IEEE Transactions on Biomedical Engineering, 38(11): 1130-1140, 1991.68Gardner "Natriuretic Peptides: Markers or Modulators of Cardiac Hypertrophy?", Trends in Endocrinology and Metabolism, 14(9): 411-416, Nov. 2003.69Gill et al. "Refractory Period Extension During Ventricular Pacing at Fibrillatory Pacing Rates", Pacing and Clinical Elctrophysiology, 20(3): 647-653, 1997, Abstract.70Gill et al. "Refractory Period Extension During Ventricular Pacing at Fibrillatory Pacing Rates", PACE, 20(Part I): 647-653, 1997.71Gilmour Jr. et al. "Dynamics of Circus Movement Re-Entry Across Canine Purkinje Fibre-Muscle Junctions", The Journal of Physiology, 476(3): 473-485, 1994.72Gilmour Jr. et al. "Overdrive Suppression of Conduction at the Canine Purkinje-Muscle Junction", Circulation, 76(6): 1388-1396, 1987.73Gold et al. "Evidence That Glucose 'Marks' B Cells Resulting in Preferential Release of Newly Synthesized Insulin", Science, 218(4567): 56-58, 1982. Abstract.74Gold et al. "Evidence That Glucose �Marks� B Cells Resulting in Preferential Release of Newly Synthesized Insulin", Science, 218(4567): 56-58, 1982. Abstract.75Gold et al. "Evidence That Glucose �Marks� Beta Cells Resulting in Preferential Release of Newly Synthesized Insulin", Science, 218(4567): 56-58, Oct. 1, 1982. Abstract.76Gomis et al. "Oscillatory Patterns of Electrical Activity in Mouse Pancreatic Islets of Langerhans Recorded In Vivo", European Journal of Physiology, 432(3): 510-515, 1996.77Gomis et al. "Oscillatory Patterns of Electrical Activity in Mouse PancreaticIslets of Langerhans Recorded in Vivo", Pfl?gers Archiv European Journal of Physiology, 432(3): 510-515, 1996.78Gomis et al. "Oscillatory Patterns of Electrical Activity in Mouse PancreaticIslets of Langerhans Recorded in Vivo", Pfl�gers Archiv European Journal of Physiology, 432(3): 510-515, 1996.79Gussoni et al. "Dystrophin Expression in the MDX Mouse Restored by Stem Cell Transplantation", Nature, 401(6751): 390-394, 1999. Abstract.80Ham et al. "Classification of Cardiac Arrhythmias Using Fuzzy Artmap", IEEE Transactions on Biomedical Engineering, 43(4): 425-429, 1996, Abstract.81Hammond et al. "Motor Innervation of the Cricopharyngeus Muscle by the Recurrent Lanryngeal Nerve", Journal of Applied Physiology, JAP, 83: 89-94, 1997.82Highfill et al. "Large-Scale Production of Murine Bone Marrow Cells in an Airlift Packed Bed Bioreactor", Biotechnology and Bioengineering, 50(5): 514-520, 1996.83Hinke et al. "Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon Characterization of Glucagon Degradation Products and DPIV-Resistant Analogs", The Journal of Biological Chemistry, 275(6): 3827-3834, 2000.84Hinke et al. "Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon. Characterization of Glucagon Degradation Products and DPIV-Resistant Analogs", The Journal of Biological Chemistry, 275(6): 3827-3834, Feb. 11, 2000.85Hoffman et al. "Effects of Postextrasystolic Potentiation on Normal and Failing Hearts", Bulletin of the New York Academy of Medicine, 41(5): 498-534, 1965.86Hoist et al. "Nervous Control of Pancreatic Endocrine Secretion in Pigs. I. Insulin and Glucagon Responses to Electrical Stimulation of the Vagus Nerves", Acta Physiologica Scandinavica, 111(1): 1-7, 1981. Abstract. p. 5, r-h Col., Last Line-p. 6, 1-h Col., First Line.87Hoist et al. "Nervous Control of Pancreatic Endocrine Secretion in Pigs. I. Insulin and Glucagon Responses to Electrical Stimulation of the Vagus Nerves", Acta Physiologica Scandinavica, 111(1): 1-7, 1981. Abstract. p. 5, r-h Col., Last Line�p. 6, 1-h Col., First Line.88Hoist et al. "Nervous Control of Pancreatic Endocrine Secretion in Pigs. I. Insulin and Glucagon Responses to Electrical Stimulation of the Vagus Nerves", Acta Physiologica Scandinavica, 111(1): Jan. 1-7, 1981. Abstract.89Holst et al. "Nervous Control of Pancreatic Endocrine Secretion in Pigs. I. Insulin and Glucagon Responses to Electrical Stimulation of the Vagus Nerves", Acta Physiologica Scandinavica, 111(1): Jan. 1-7, 1981. Abstract.90Holst et al. "Nervous Control of Pancreatic Endocrine Secretion in Pigs. II. The Effect of Pharmacological Blocking Agents on the Response to Vagal Stimulation", Acta Physiologica Scandinavica, 111(1): 9-14, 1981. Abstract.91Homer et al. "Electrode for Recording Direction of Activation, Conduction Velocity and Monophasic Action Potential of Myocardium", American Journal of Physiology, 272(4): H1917-H1927, 1997. Abstract.92Homer et al. "Electrode for Recording Direction of Activation, Conduction Velocity, and Monophasic Action Potential of Myocardium", American Journal of Physiology, 272: H1917-H1927, 1997.93Horner et al. "Electrode for Recording Direction of Activation, Conduction Velocity and Monophasic Action Potential of Myocardium", American Journal of Physiology, 272(4): H1917-H1927, 1997. Abstract.94Inter Partes Reexamination Communication of Patent US 6,330,476 Dated Sep. 4, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 95/000,032.95International Preliminary Report on Patentability Dated Aug. 30, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/000204.96International Preliminary Report on Patentability Dated Dec. 1, 2004 From the International Preliminary Examining Authority Re.: Application No. PCT/IL03/00736.97International Preliminary Report on Patentability Dated Jun. 21, 2007 From the International Bureau of WIPO Re.: Application No. Jun. 21, 2007.98International Preliminary Report on Patentability Dated Nov. 15, 2007 From the International Bureau of WIPO Re.: Application No. PCT/US2006/017281.99International Preliminary Report on Patentability Dated Sep. 27, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/000345.100International Search Report and the Written Opinion Dated May 12, 2006 From the International Searching Authority Re.: Application No. PCT/US05/44557.101International Search Report and the Written Opinion Dated Oct. 16, 2006 From the International Searching Authority Re.: Application No. PCT/US06/17281.102International Search Report and the Written Opinion Dated Sep. 29, 2006 From the International Searching Authority Re.: Application No. PCT/IL06/00204.103International Search Report Dated Sep. 13, 2004 From the International Searching Authority Re.: Application No. PCT/IL03/00736.104Invitation Pursuant to Rule 62a(1) EPC and Rule 63(1) EPC Dated May 5, 2010 From the European Patent Office Re.: Application No. 04719312.3.105Jaremko et al. "Advances Toward the Implantable Artificial Pancreas for Treatment of Diabetes", Diabetes Care, 21(3): 444-450, 1998.106Jaremko et al. "Advances Towards the Implantable Artifical Pancreas for Treatment of Diabetes", Diabetes Care, 21(3): 444-450, 1998.107Josephson "Clinical Cardiac Electrophysiology: Techniques and Interpertations", Lea & Febiger, 2nd Ed., 2 P., 1991.108King et al. "The Inotropic Action of Paired Pulse Stimulation in the Normal and Failing Heart: An Experimental Study", Cardiovascular Research, 2: 122-129, 1968.109Kinsley et al. "Effect of Field Stimulation on Cellular Repolarization in Rabbit Myocardium Implications for Reentry Induction", Circulation Research, 70: 707-715, 1991.110Knisley et al. "Prolgongation and Shortening of Action Potentials by Electrical Shocks in Frog Ventricular Muscle", American Journal of Physiology, 266(6): H2348-H2358, 1994, Abstract.111Knisley et al. "Effect of Field Stimulation on Cellular Repolarization in Rabbit Myocardium. Implications for Reentry Induction", Circulation Research, 70(4): 707-715, Apr. 1992.112Knisley et al. "Prolongation and Shortening of Action Potentials by Electrical Shocks in Frog Ventricular Muscle", American Journal of Physiology, 266(6): H2348-H2358, 1994, Abstract.113Knisley et al. "Prolongation and Shortening of Action Potentials by Electrical Shocks in Frog Ventricular Muscle", American Journal of Physiology, 266: H2348-H2358, 1994.114Koller et al. "Relation Between Repolarization and Refractoriness During Programmed Electrical Stimulation in the Human Right Ventricle", Circulation, 91(9): 2378-2384, 1995, Abstract.115Koller et al. "Relation Between Repolarization and Refractoriness During Programmed Electrical Stimulation in the Human Right Ventricle", Circulation, 91:2378-2384, 1995.116Kurose et al. "Glucagon, Insulin and Somatostatin Secretion in Response to Sympathetic Neural Activation in Streptozotocin-Induced Diabetic Rats. A Study With the Isolated Perfused Rat Pancreas In Vitro", Diabetologia, 35: 1035-1041, 1992. Abstract.117Kurose et al. "Glucagon, Insulin and Somatostatin Secretion in Response to Sympathetic Neural Activation in Streptozotocin-Induced Diabetic Rats. A Study With the Isolated Perfused Rat Pancreas In Vitro", Diabetologia, 35(11): 1035-1041, Nov. 1992. Abstract.118Langberg et al. "Identification of Ventricular Tachycardia with Use of the Morphology of the Endocardial Electrogram", Circulation, 77(6): 1363-1369, 1988.119Langberg et al. "Identification of Ventricular Tachycardia With Use of the Morphology of the Endocardial Electrogram", Circulation, 77: 1363-1369, 1988.120Lindstrom et al. "Intracellular Calcium Oscillations in a T-Cell Line After Exposure to Extremely-Low-Frequency Magnetic Fields with Variable Frequencies and Flux Densities", Bioelectromagnetics, 16(1): 41-47, 1995, Abstract.121Lindstr�m et al. "Intracellular Calcium Oscillations in a T-Cell Line After Exposure to Extremely-Low-Frequency Magnetic Fields with Variable Frequencies and Flux Densities", Bioelectromagnetics, 16(1): 41-47, 1995, Abstract.122Lindstr�m et al. "Intracellular Calcium Oscillations in a T-Cell Line After Exposure to Extremely-Low-Frequency Magnetic Fields With Variable Frequencies and Flux Densities", Bioelectromagnetics, 16: 41-47, 1995.123Loginov et al. "Effects of an Impulse Electromagnetic Field on Calcium Ion Accumulation in the Sarcoplasmic . . . ", Kosm. Biol. Aviakosm. Med., 15: 51-53, 1991.124Lubart et al. "Effect of Light on Calcium Transport in Bull Sperm Cells", Journal of Photochemistry and Photobiology B, Biology, 15(4): 337-341, Sep. 15, 1992. Abstract.125Luiken et al. "Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling", Diabetes, 52: 1627-1634, 2003.126Magnus et al. "Model of Beta-Cell Mitochondrial Calcium Handling and Electrical Activity. II. Mitochondrial Variables", American Journal of Physiology, Cell Physiology, 274(43): C1174-C1184, 1998.127Magnus et al. "Model of β-Cell Mitochondrial Calcium Handling and Electrical Activity. II. Mitochondrial Variables", American Journal of Physiology, Cell Physiology, 274(43): C1174-C1184, 1998.128Matheny et al. "Vagus Nerve Stimulation as a Method to Temporarily Slow or Arrest the Heart", Annals of Thoracic Surgery, 63(6): S28-29, 1997, Abstract.129McVeigh et al. "Noninvasive Measurement of Transmural Gradients in Myocardial Strain With MR Imaging", Radiology, 180(3): 677, 679-684, 1991.130Mercando et al. "Automated Detection of Tachycardias by Antitachycardia Devices", Cardiac Electrophysiology: From Cell to Bedside, Chap.100: 943-948, 2004.131Meurer et al. "Properties of Native and In Vitro Glycosylated Forms of the Glucogan-Like Peptide-1 Receptor Antagonist Exendin(9-39)", Metabolism, 48(6): 716-724, 1999.132Meurer et al. "Properties of Native and in Vitro Glycosylated Forms of the Glucogan-Like Peptide-1 Receptor Antagonist Exendin(9-39)", Metabolism: Clinical and Experimental, 48(6): 716-724, Jun. 1999. Abstract.133Misler et al. "Electrophysiology of Stimulus-Secretion Coupling in Human B-Cells", Diabetes, 41(10): 1221-1228, 1992. Abstract.134Misler et al. "Electrophysiology of Stimulus-Secretion Coupling in Human Beta-Cells", Diabetes, 41(10): 1221-1228, Oct. 1992. Abstract.135Moran et al. "Digoxin-Specific Fab Fragments Impair Renal Function in the Rat", Journal of Pharmacy and Pharmacology, 46(10): 854-856, 1994, Abstract.136Moran et al. "Digoxin-Specific Fab Fragments Impair Renal Function in the Rat", Journal of Pharmacy and Pharmacology, 46(10): 854-856, 1994. Abstract.137Morse et al. "A Guide to Cardiac Pacemakers, Defibrillators and Related Products".138Nadal et al. "Homologous and Heterologous Asynchronicity Between Identified Alpha-, Beta- and Gamma-Cells Within Intadct Islets of Langerhans in the Mouse", Journal of Physiology, 517(Pt 1): 85-93, 1999.139Nadal et al. "Homologous and Heterologous Asynchronicity Between Identified ?-, ?- and ?-Cells Within Intact Islets of Langerhans in the Mouse", Journal of Physicology, 517(Pt.1): 85-93, 1999.140Nadal et al. "Homologous and Heterologous Asynchronicity Between Identified α-, 62- and δ-Cells Within Intact Islets of Langerhans in the Mouse", Journal of Physicology, 517(Pt.1): 85-93, 1999.141Nannini et al. "Muscle Recruitment With Intrafascicular Electrodes",IEEE Transactions on Biomedical Engineering, 38: 769-776, 1-991, Abstract.142Notice of Allowance Dated Dec. 28, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.143Notice of Allowance Dated Jan. 14, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.144Notice of Allowance Dated May 27, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.145Notice of Allowance Dated Sep. 7, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.146Notice of Non-Compliant Amendment Dated Dec. 12, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/792,811.147Notification of Reasons of Rejection Dated Sep. 29, 2008 From the Japanese Patent Office Re.: Application No. 2004-534013 and Its Translation Into English.148Office Action Dated Apr. 13, 2010 From the State intellectual Property Office of the People's Republic of China Re. Application No. 200480027293.3 and Its Translation Into English.149Office Action Dated Dec. 15, 2008 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5 and Its Translation Into English.150Office Action Dated Dec. 4, 2009 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 03824661.9 and Its Translation Into English.151Office Action Dated Feb. 21, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 10/116,201.152Office Action Dated Jan. 18, 2012 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5 and Its Translation Into English.153Office Action Dated Jan. 8, 2010 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5 and Its Translation Into English.154Office Action Dated Jul. 13, 2009 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 200480027083.3 and Its Translation Into English.155Office Action Dated May 8, 2009 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 03824661.9 and Its Translation Into English.156Office Action Dated Nov. 2, 2007 From the Patent Office of the People's Republic of China Re.: Application No. 2004800009336.9.157Office Action Dated Nov. 25, 2010 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5 and Its Translation Into English.158Office Action Dated Nov. 7, 2008 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 03824661.9 and Its Translation Into English.159Office Action Dated Oct. 12, 2004 From the Israeli Patent Office Re.: Application No. 128955.160Official Action Dated Apr. 14, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.161Official Action Dated Apr. 16, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/566,775.162Official Action Dated Apr. 18, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.163Official Action Dated Apr. 27, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/570,576.164Official Action Dated Apr. 28, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/931,889.165Official Action Dated Apr. 28, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.166Official Action Dated Apr. 29, 2009 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.167Official Action Dated Apr. 30, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.168Official Action Dated Apr. 30, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.169Official Action Dated Aug. 1, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.170Official Action Dated Aug. 18, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/570,576.171Official Action Dated Aug. 28, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/802,685.172Official Action Dated Aug. 28, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.173Official Action Dated Aug. 30, 2006 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.174Official Action Dated Aug. 31, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/536,794.175Official Action Dated Aug. 31, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.176Official Action Dated Aug. 8, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.177Official Action Dated Aug. 9, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.178Official Action Dated Dec. 14, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/884,389.179Official Action Dated Dec. 15, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.180Official Action Dated Dec. 15, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 12/910,943.181Official Action Dated Dec. 2, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.182Official Action Dated Dec. 20, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.183Official Action Dated Dec. 23, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.184Official Action Dated Dec. 24, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.185Official Action Dated Dec. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.186Official Action Dated Dec. 4, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/884,389.187Official Action Dated Dec. 5, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.188Official Action Dated Dec. 8, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.189Official Action Dated Feb. 15, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/802,685.190Official Action Dated Feb. 17, 2012 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.191Official Action Dated Feb. 24, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.192Official Action Dated Feb. 28, 2008 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.193Official Action Dated Feb. 4, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.194Official Action Dated Jan. 13, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.195Official Action Dated Jan. 21, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/570,576.196Official Action Dated Jan. 24, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/919,491.197Official Action Dated Jan. 3, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.198Official Action Dated Jan. 4, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/673,812.199Official Action Dated Jan. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/802,685.200Official Action Dated Jan. 6, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.201Official Action Dated Jan. 6, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.202Official Action Dated Jan. 6, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.203Official Action Dated Jul. 14, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/526,708.204Official Action Dated Jul. 15, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/116,201.205Official Action Dated Jul. 18, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.206Official Action Dated Jul. 19, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/526,708.207Official Action Dated Jul. 21, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/802,685.208Official Action Dated Jul. 31, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.209Official Action Dated Jul. 9, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.210Official Action Dated Jun. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.211Official Action Dated Jun. 11, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.212Official Action Dated Jun. 11, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.213Official Action Dated Jun. 13, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.214Official Action Dated Jun. 17, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.215Official Action Dated Jun. 19, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.216Official Action Dated Jun. 23, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.217Official Action Dated Jun. 26, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/536,794.218Official Action Dated Jun. 28, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.219Official Action Dated Mar. 25, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.220Official Action Dated Mar. 27, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.221Official Action Dated Mar. 31, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.222Official Action Dated Mar. 31, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/673,812.223Official Action Dated Mar. 6, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.224Official Action Dated Mar. 6, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.225Official Action Dated May 12, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.226Official Action Dated May 13, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.227Official Action Dated May 21, 2007 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.228Official Action Dated May 21, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 10/116,201.229Official Action Dated May 26, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.230Official Action Dated May 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/884,389.231Official Action Dated Nov. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.232Official Action Dated Nov. 5, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.233Official Action Dated Nov. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.234Official Action Dated Nov. 8, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.235Official Action Dated Oct. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.236Official Action Dated Oct. 10, 2008 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.237Official Action Dated Oct. 11, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/919,491.238Official Action Dated Oct. 13, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.239Official Action Dated Oct. 13, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/919,491.240Official Action Dated Oct. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.241Official Action Dated Oct. 6, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.242Official Action Dated Oct. 8, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/116,201.243Official Action Dated Sep. 11, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.244Official Action Dated Sep. 11, 2009 From the US Patent and Trademark Office Re. U.S. Appl. No. 09/980,748.245Official Action Dated Sep. 12, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.246Official Action Dated Sep. 13, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.247Official Action Dated Sep. 14, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.248Official Action Dated Sep. 25, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/526,708.249Official Action Dated Sep. 27, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.250Official Action Dated Sep. 29, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.251Official Action Dated Sep. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.252Official Action of Apr. 30, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.253Official Action of Nov. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.254Ohinata et al. "Proadrenomedullin N-Terminal 20 peptide (PAMP) elevates Blood Glucose Levels Via Bombesin Receptor in Mice", FEBS Letters, 473(2): 207-211, 2000.255Ohinata et al. "Proadrenomedullin N-Terminal 20 Peptide (PAMP) Elevates Blood Glucose Levels Via Bombesin Receptor in Mice", FEBS Letters, 473(2): 207-211, May 2000. Abstract.256Palti et al. "Islets of Langerhans Generate Wavelike Electric Activity Modulated by Glucose Concentration", Diabetes, 45: 595-601, 1996. Abstract.257Palti et al. "Islets of Langerhans Generate Wavelike Electric Activity Modulated by Glucose Concentration", Diabetes, 45(5): 595-601, May 1996. Abstract.258Park et al. "Significant Cholinergic Role in Secreted-Stimulated Exocrine Secretion in Isolated Rat Pancreas", American Journal of Physiology, 274(2 Pt 1): G413-G418, 1998. Abstract.259Park et al. "Significant Cholinergic Role in Secretin-Stimulated Exocrine Secretion in Isolated Rat Pancreas", American Journal of Physiology, AJP�Gastrointestinal and Liver Physiology, 274(2): G413-G418, Feb. 1998.260Patterson et al. "Therapeutic Angiogenesis.The New Electrophysiology?", Circulation, 99: 2614-2616, 1999.261Patterson et al. "Therapeutic Angiogenesis: The New Electrophysiology?", Circulation, 99(20): 2614-2616, 1999.262Paul et al. "Automatic Recognition of Ventricular Arrhythmias Using Temporal Electrogram Analysis", PACE, 14: 1265-1273, 1991.263Pokrovsky et al. "Physiology of Man", 1: 82-83, 94, 2: 42, 54.264Pokrovsky et al. "Physiology of Man", Moscow Medicine, 1: 82-83, 94, 2: 42, 54, Translation of Extracts. Translation English!.265Porksen et al. "Section 6: Pulsatile and Phasic Insulin Release in Normal and Diabetic Man. Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes", Diabetes, 51(Supp1.1): S245-S254, 2002.266P�rksen et al. "Section 6: Pulsatile and Phasic Insulin Release in Normal and Diabetic Man. Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes", Diabetes, 51(Supp1.1): S245-S254, Feb. 2002.267Porksen et al. "Section 6: Pulsatile and Phasic Insulin Release in Normal and Diabetic Man. Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes", Diabetes, 51(Suppl.1): S245-S254, Feb. 2002.268Pre-Appeal Brief Request for Review Dated Aug. 9, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.269Pumir et al. "Control of Rotating Waves in Cardiac Muscle: Analysis of the Effect of Electric Fields", Proceedings: Biological Sciences, 257(1349): 129-134, 1994, Abstract.270Pumir et al. "Control of Rotating Waves in Cardiac Muscle: Analysis of the Effect of Electric Field", Proceedings of the Royal Society B: Biological Sciences, 257(1349): 129-134, 1994.271Pumir et al. "Control of Rotating Waves in Cardiac Muscle: Analysis of the Effect of Electric Fields", Proceedings of the Royal Society B: Biological Sciences, 257(1349): 129-134, 1994. Abstract.272Ranjan et al. "Electrical Stimulation of Cardiac Myocytes", Annals of Biomedical Engineering, 23(6): 812-821, 1995, Abstract.273Request for Ex Parte Reexamination of Patent No. 6,363,279 Dated Jun. 8, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.274Request for Ex Parte Reexamination of Patent No. 6,363,279, Response to Official Action Dated Jun. 20, 2008 Submitted Aug. 20, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.275Request for Ex Parte Reexamination of Patent No. 6,363,279�IDS Submitted Dec. 31, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.276Request for Ex Parte Reexamination of Patent No. 6,363,279�Notice of Intent to Issue Reexamination Certificate Dated Mar. 18, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.277Request for Ex Parte Reexamination of Patent No. 6,363,279�Official Action Dated Jun. 20, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.278Request for Ex Parte Reexamination of Patent No. 6,363,279�Order Granting Request Dated Nov. 5, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,688.279Request for Ex Parte Reexamination of US Patent No. 6,236,887 Dated Jun. 13, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.280Request for Ex Parte Reexamination of US Patent No. 6,236,887�IDS Submitted Oct. 17, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.281Request for Ex Parte Reexamination of US Patent No. 6,236,887�IDS Submitted Sep. 29, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.282Request for Ex Parte Reexamination of US Patent No. 6,236,887�Notice of Intent to Issue Ex Parte Examination Certificate Dated Mar. 19, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.283Request for Ex Parte Reexamination of US Patent No. 6,236,887�Official Action and IDS Considered Dated Jun. 20, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.284Request for Ex Parte Reexamination of US Patent No. 6,236,887�Official Action Granting Request for Ex Parte Examination Dated Aug. 17, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,707.285Request for Ex Parte Reexamination of US Patent No. 6,298,268 Dated Oct. 10, 2003, U.S. Appl. No. 90/006,788.286Request for Ex Parte Reexamination of US Patent No. 6,298,268 Order Granting Request for Ex Parte Reexamination Dated Dec. 19, 2003, U.S. Appl. No. 90/006,788.287Request for Ex Parte Reexamination of US Patent No. 6,298,268�Certificate of Reexamination Issued Mar. 7, 2006, U.S. Appl. No. 90/006,788.288Request for Ex Parte Reexamination of US Patent No. 6,298,268�IDS Considered Feb. 22, 2005, U.S. Appl. No. 90/006,788.289Request for Ex Parte Reexamination of US Patent No. 6,298,268�Notice of Intent to Issue Certificate of Reexamination Dated Mar. 29, 2005, U.S. Appl. No. 90/006,788.290Request for Ex Parte Reexamination of US Patent No. 6,317,631�Amendment in Response to Official Action Dated Jun. 20, 2008, Filed Aug. 20, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.291Request for Ex Parte Reexamination of US Patent No. 6,317,631�IDS Dated Dec. 31, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.292Request for Ex Parte Reexamination of US Patent No. 6,317,631�IDS Dated Jun. 8, 2007, U.S. Appl. No. 90/008,689.293Request for Ex Parte Reexamination of US Patent No. 6,317,631�IDS Dated Sep. 26, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.294Request for Ex Parte Reexamination of US Patent No. 6,317,631�Notice of Intent to Issue Certificate of Reexamination Dated Mar. 18, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.295Request for Ex Parte Reexamination of US Patent No. 6,317,631�Official Action Dated Jun. 20, 2008, U.S. Appl. No. 90/008,689.296Request for Ex Parte Reexamination of US Patent No. 6,317,631�Order Granting Reexamination Dated Nov. 5, 2007, U.S. Appl. No. 90/008,689.297Request for Ex Parte Reexamination of US Patent No. 6,330,476 Dated Dec. 31, 2003 From the US Patent and Trademark Office Re.: U.S. Appl. No. 95/000,032.298Request for Ex Parte Reexamination of US Patent No. 6,330,476�Comments by 3rd Party Requestor, Response Thereto and Official Action Issued Jul. 16, 2008, U.S. Appl. No. 95/000,032.299Request for Ex Parte Reexamination of US Patent No. 6,330,476�Communication of Right to Appeal dated Jul. 16, 2008, U.S. Appl. No. 95/000,032.300Request for Ex Parte Reexamination of US Patent No. 6,330,476�IDS Dated May 31, 2006.301Request for Ex Parte Reexamination of US Patent No. 6,330,476�IDS Filed May 4, 2007, U.S. Appl. No. 95/000,032.302Request for Ex Parte Reexamination of US Patent No. 6,330,476�Official Action by Uspto Issued Mar. 23, 2004, U.S. Appl. No. 95/000,032.303Request for Ex Parte Reexamination of US Patent No. 6,330,476�Order Granting Request for Reexamination Dated Mar. 23, 2004 From the US Patent and Trademark Office Re.: U.S. Appl. No. 95/000,032.304Request for Ex Parte Reexamination of US Patent No. 6,463,324 Dated Nov. 1, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.305Request for Ex Parte Reexamination of US Patent No. 6,463,324�Amendment in Response to Official Action Dated Aug. 1, 2007 Filed Oct. 1, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.306Request for Ex Parte Reexamination of US Patent No. 6,463,324�Certificate of Reexamination Dated Apr. 29, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.307Request for Ex Parte Reexamination of US Patent No. 6,463,324�Official Action Dated Aug. 1, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.308Request for Ex Parte Reexamination of US Patent No. 6,463,324�Official Action, Interview Summary and References Considered Dated Nov. 6, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.309Request for Ex Parte Reexamination of US Patent No. 6,463,324�Official Action�Notice of Intent to Reexamine Dated Jan. 24, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.310Response Dated Apr. 10, 2011 to Official Action of Jan. 6, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.311Response Dated Apr. 20, 2006 to Communication Pursuant of Article 96(2) EPC of Nov. 2, 2005 From the European Patent Office Re.: Application No. 97929478.2.312Response Dated Apr. 3, 2008 to Official Action of Jan. 3, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/116,201.313Response Dated Apr. 6, 2010 to Official Action of Oct. 6, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.314Response Dated Aug. 1, 2010 to Notification of Reasons of Rejection of Apr. 12, 2010 From the Japanese Patent Office Re.: Application No. 2006-525265.315Response Dated Aug. 10, 2011 to Official Action of May 13, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.316Response Dated Aug. 2, 2010 to Official Action of Mar. 31, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.317Response Dated Aug. 20, 2008 to Official Action of Jun. 20, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,689.318Response Dated Aug. 24, 2010 to the Supplementary European Search Report of Jun. 7, 2010 From the European Patent Office Re. Application No. 04770468.9.319Response Dated Aug. 26, 2010 to Official Action of May 26, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.320Response Dated Aug. 31, 2011 to Official Action of Mar. 31, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/673,812.321Response Dated Dec. 13, 2010 to Official Action of Jun. 11, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/550,560.322Response Dated Dec. 13, 2010 to Official Action of Oct. 13, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/919,491.323Response Dated Dec. 24, 2006 to Office Action of Jul. 18, 2006 From the Japanese Patent Office Re.: Application No. 10-513446.324Response Dated Dec. 25, 2006 to Notice of Reasons for Rejection of Jul. 18, 2006 From the Japanese Patent Office Re.: Application No. 09-529637.325Response Dated Dec. 27, 2011 to Communication Pursuant to Article 94(3) EPC of Aug. 26, 2011 From the European Patent Office Re.: Application No. 05853465.2.326Response Dated Dec. 8, 2011 to Office Action of Aug. 3, 2011 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5.327Response Dated Feb. 14, 2011 to Official Action Dated Jan. 13, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.328Response Dated Feb. 18, 2010 to Official Action of Aug. 18, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/570,576.329Response Dated Feb. 2, 2010 to Official Action of Dec. 2, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.330Response Dated Feb. 3, 2011 to Official Action of Jan. 3, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.331Response Dated Feb. 4, 2010 to Official Action of Dec. 4, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/884,389.332Response Dated Feb. 7, 2010 to Official Action of Dec. 2, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.333Response Dated Feb. 7, 2010 to Official Action of Nov. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.334Response Dated Feb. 7, 2011 to Official Action of Oct. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.335Response Dated Feb. 8, 2010 to Official Action Dated Oct. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/237,263.336Response Dated Feb. 9, 2010 to Official Action of Oct. 8, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/116,201.337Response Dated Jan. 17, 2008 to Official Action of Jul. 18, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.338Response Dated Jan. 24, 2011 to Supplementary Partial European Search Report of Nov. 4, 2010 From the European Patent Office Re. Application No. 04719312.3.339Response Dated Jan. 25, 2007 to Examination Report of Jul. 7, 2006 From the Government of India, Patent Office Re.: Application No. 533/CHENP/2005.340Response Dated Jan. 31, 2011 to Official Action of Sep. 29, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.341Response Dated Jan. 5, 2010 to Official Action of Oct. 8, 2009 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/566,775.342Response Dated Jul. 1, 2010 to Invitation Pursuant to Rule 62a(1) EPC and Rule 63(1) EPC of May 5, 2010 From the European Patent Office Re.: U.S. Appl. No. 04719312.3.343Response Dated Jul. 13, 2010 to Notice of Reasons for Rejection of Apr. 27, 2010 From the Japanese Patent Office Re.: Application No. 2007-206282.344Response Dated Jul. 26, 2010 to Official Action of Mar. 25, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.345Response Dated Jul. 27, 2010 to Communication Pursuant to Article 94(3) EPC of Jan. 27, 2010 From the European Patent Office Re. Application No. 07110023.4.346Response Dated Jul. 27, 2011 to Official Action of Apr. 28, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/931,889.347Response Dated Jul. 27, 2011 to Official Action of Apr. 28, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.348Response Dated Jul. 31, 2011 to Official Action of Apr. 14, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.349Response Dated Jun. 7, 2010 to Official Action of Jan. 6, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 11/933,168.350Response Dated Mar. 1, 2010 to Official Action of Aug. 28, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.351Response Dated Mar. 15, 2010 to Official Action of Sep. 14, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.352Response Dated Mar. 25, 2010 to Official Action of Sep. 25, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/526,708.353Response Dated Mar. 3, 2010 to Official Action of Sep. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.354Response Dated Mar. 4, 2010 to Official Action of Nov. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/549,216.355Response Dated May 15, 2011 to Office Action of Nov. 25, 2010 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5. & Claims in English.356Response Dated May 21, 2008 to Office Action of Dec. 11, 2007 From the Japanese Patent Office Re.: Application No. 09-525055.357Response Dated May 3, 2010 to Official Action of Dec. 3, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/318,845.358Response Dated May 4, 2009 to Official Action of Nov. 3, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/116,201.359Response Dated May 4, 2010 to Official Action of Jan. 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/802,685.360Response Dated May 6, 2010 to Office Action Dated Jan. 8, 2010 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5.361Response Dated May 7, 2007 to Examination Report of Mar. 2, 2007 From the Government of India, Patent Office Re.: Application No. 533/CHENP/2005.362Response Dated Nov. 22, 2009 to Official Action of Jun. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.363Response Dated Nov. 22, 2010 to Official Action of Jul. 21, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/802,685.364Response Dated Oct. 1, 2007 to Official Action of Aug. 1, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 90/008,312.365Response Dated Oct. 11, 2011 to Official Action of May 12, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.366Response dated Oct. 12, 2010 to Official Action of Jun. 11, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,064.367Response Dated Oct. 13, 2010 to Official Action of Apr. 30, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/932,149.368Response Dated Oct. 28, 2010 to Official Action of Jun. 28, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,889.369Response Dated Oct. 4, 2007 to Official Action of Sep. 4, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 95/000,032.370Response Dated Sep. 1, 2004 to Communication Pursuant to Article 96(2) EPC of Mar. 2, 2004 From the European Patent Office Re.: U.S. Appl. No. 97929478.2.371Response Dated Sep. 20, 2010 to Official Action of May 21, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 10/116,201.372Response Dated Sep. 27, 2010 to Official Action of Apr. 27, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/570,576.373Response Dated Sep. 30, 2010 to Official Action of Apr. 30, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.374Response in Conjunction With an RCE Dated Jul. 18, 2010 to Official Action Dated Feb. 4, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.375Response in Conjunction With an RCE Dated Jul. 21, 2010 to Official Action of Feb. 4, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/039,845.376Rivera et al. "Regualtion of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum", Science, 287: 826-830, 2000.377Rivera et al. "Regulation of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum", Science, 287(5454): 826-830, Feb. 4, 2000. Abstract.378Rsponse Dated Oct. 5, 2010 to Official Action of May 5, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/884,389.379Saihara "Summation of Excitation With a Single Conditioning Stimulus in the Canine Heart", PACE, 13: 52-58, 1990.380Saksena et al. "Prevention of Recurrent Atrial Fibrillation With Chronic Dual-Site Right Atrial Pacing", Journal of the American College of Cardiology, 28(3): 687-694, 1996, Abstract.381Sakuma et al. "A Model Analysis of Aftereffects of High-Intensity DC Stimulation on Action Potential of Ventricular Muscle", IEEE Transactions on Biomedical Engineering, 45(2): 258-267, 1998.382San Mauro et al. "Nerves of the Heart: A Comprehensive Review With a Clinical Point of View", Neuroanatomy, 8: 28-31, 2009.383Saveliev et al. "Guidebook on Clinical Endoscopy", Moscow Medicine, p. 21, 35, Extract, 1985.384Schirra et al. "Exendin(9-39) Amide Is an Antagonist of Glucagon-Like Peptide-1(7-36) Amide in Humans", Journal of Clinical Investigation, 101(7): 1421-1430, Apr. 1998.385Schirra et al. "Exendin(9-39)Amide Is an Antagonist of Glucagon-Like Peptide-1(7-36)Amide in Humans", Journal of Clinical Investigation, 101(7): 1421-1430, 1996.386Schirra et al. "Mechanisms of the Antidiabetic Action of Subcutaneous Glucagon-Like Peptide-1 (17-36) Amide in Non-Insulin Dependent Diabetes Mellitus", Journal of Endocrinology Ltd., 156(1): 177-186, Jan. 1998. Abstract.387Schwartz et al. "Exposure of Frog Hearts to CW or Amplitude-Modified VHF Fields: Selective Efflux of Calcium Ions at 16 Hz", Bioelectromagnetics, 11(4): 349-358, 1990, Abstract.388Serre et al. "Exendin-(9-39) Is an Inverse Agonist of the Murine Glucagon-Like Peptide-1 Receptor: Implications for Basal intracellular Cyclic Adenosine 3′,5′-Monophosphate Levels and ?-Cells Glucose Competence", Endocrinology, 139(11): 4448-4454, 1998.389Serre et al. "Exendin-(9-39) Is an Inverse Agonist of the Murine Glucagon-Like Peptide-1 Receptor: Implications for Basal Intracellular Cyclic Adenosine 3′,5′-Monophosphate Levels and B-Cells Glucose Competence", Endocrinology, 139(1 1): 4448-4454, 1998.390Serre et al. "Exendin-(9-39) Is an Inverse Agonist of the Murine Glucagon-Like Peptide-1 Receptor: Implications for Basal Intracellular Cyclic Adenosine 3′,5′-Monophosphate Levels and β-Cells Glucose Competence", Endocrinology, 139(11): 4448-4454, 1998.391Shah et al. "Impact of Lack of Suppression of Glucagon on Glucose Tolerance in Humans", American Journal of Physiology, 277(2 Pt 1): E283-E290, 1999.392Shah et al. "Impact of Lack of Suppression of Glucagon on Glucose Tolerance in Humans", American Journal of Physiology, AJP�Endocrinology and Metabolism, 277(2 Pt.1): E283-E290, 1999.393Shmit et al. "Physiology of Man", Moscow Medicine, 1: 78, Translation of Extracts, 1996. Translation in English.394Shmit et al. "Physiology of Man", Moscow Medicine, Mir, 1: 78, 1996.395Shuba et al. "Physiology of Vessel Smooth Muscles", Kiev Naukova Dumka, 142: 11-15, 142, 1988.396Shuba et al. "Physiology of Vessel Smooth Muscles", Naukova Dumka, p. 11-15, 142, Translation of Extracts, 1988. Translation in English!.397Shumaik et al. "Oleander Poisoning: Treatment With Digoxin-Specific Fab Antibody Fragments", Annals of Emergency Medicine, 17(7): 732-735, 1988.398Singh et al. "Effect of Islet Hormones on Nerve-Mediated and Acetylcholine- Evoked Secretory Responses in the Isolated Pancreas of Normal and Diabetic Rats", International Journal of Molecular Medicine, 1(3): 627-634, 1998. Abstract. Abstract, p. 633, Section �Discussion�.399Singh et al. "Effects of Islet Hormones on Nerve-Mediated and Acetylcholine-Evoked Secretory Responses in the Isolated Pancreas of Normal and Diabetic Rats", International Journal of Molecular Medicine, 1(3): 627-634, Mar. 1998. Abstract.400Skale et al. "Inhibition of Premature Ventricular Extrastimuli by Subthreshold Conditioning Stimuli", J. Am. Coll. Cardiol., 6: 133-140, 1985, Abstract.401Skale et al. "Inhibition of Premature Ventricular Extrastimuli by Subthreshold Conditioning Stimuli", Journal of the American College of Cardiology, 6: 133-140, 1985. Abstract.402Skate et al. "Inhibition of Premature Ventricular Extrastimuli by Subthreshold Conditioning Stimuli", Journal of the American College of Cardiology, 6(1): 133-140, 1985.403Solomonow et al. "Control of Muscle Contractile Force Through Indirect High-Frequency Stimulation", American Journal of Physical Medicine, 62(2): 71-82, Apr. 1983. Abstract.404Soria et al. "Cytosolic Calcium Oscillations and Insulin Release in Pancreatic Islets of Langerhans", Diabetes & Metabolism, 24(1): 37-40, 1998.405Soria et al. "Cytosolic Calcium Oscillations and Insulin Release in Pancreatic Islets of Langerhans", Diabetes & Metabolism, 24: 37-40, 1998.406Stevenson et al. "Electrophysiologic Characteristics of Ventricular Tachycardia or Fibrillation in Relation to Age of Myocardial Infarction", The American Journal of Cardiology, 57(6): 387-391, Feb. 15, 1986. Abstract.407Sukhorukov et al. "The Effect of Electrical Deformation Forces on the Electropermeabilization of Erythrocyte Membranes in Low- and High-Conductivity Media", The Journal of Membrane Biology, 163(3): 235-245, 1998. Abstract.408Summons to Attend Oral Proceedings Pursuant to Rule 115(1) EPC Dated Dec. 22, 2008 From the European Patent Office Re.: Application No. 97929480.8.409Supplemental Response Dated Apr. 18, 2011 to Response of Apr. 10, 2011 to Official Action of Jan. 6, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/931,724.410Supplemental Response Dated Mar. 28, 2010 After an Interview of Mar. 4, 2010 From the US Patent and Trademark Office Re. U.S. Appl. No. 10/237,263.411Supplementary European Search Report and the European Search Opinion Dated Nov. 28, 2008 From the European Patent Office Re.: Application No. 006759102.4.412Supplementary European Search Report and the European Search Opinion Dated Nov. 28, 2008 From the European Patent Office Re.: Application No. 05853465.2.413Supplementary European Search Report Dated Jun. 7, 2010 From the European Patent Office Re. Application No. 04770468.9.414Supplementary Notice of Allowability Dated Nov. 22, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/804,560.415Supplementary Partial European Search Report Dated Nov. 4, 2010 From the European Patent Office Re. Application No. 04719312.3.416Sutton et al. "The Foundation of Cardiac Pacing, Part I: An Illustrated Practical Guide to Basic Pacing", The Bakken Research Center Series, Chap.4: 50-59, 1991.417Sutton et al. "What Is a Pacemaker?", The Foundations of Cardiac Pacing, Part I: An Illustrated Practical Guide to Basic Pacing, Chap.4.5: 73-74, 1991.418Sweeney et al. "Refractory Interval After Transcardiac Shocks During Ventricular Fibrillation", Circulation, 94: 2947-2952, 1996.419Sweeney et al. "Ventricular Refractory Period Extension Caused by Defibrillation Shocks", Circulation, 82: 965-972, 1990.420Sweeny et al. "Countershock Strength-Duration Relationship for Myocardial Refractory Period Extension", Academic Emergency Medicine, 2(1): 57-62, 1995, Abstract.421Sweeny et al. "Refractory Interval After Transcardiac Shocks During Ventricular Fibrillation", Circulation, 94(11): 2947-2952, 1996.422Sweeny et al. "Ventricular Refractory Period Extension Caused by Defibrillation Shocks", Circulation, 82(3): 965-972, 1990.423Sweeny et al. "Countershock Strength-Duration Relationship for Myocardial Refractory Period Extension", Academy of Emergency Medicine, 2: 57-62, 1995.424Sweeny et al. "Countershock Strength-Duration Relatlonship for Myocardial Refractory Period Extension", Academic Emergency Medicine, 2(1): 57-62, 1995, Abstract.425Swerdlow et al. "Cardiovascular Collapse Caused by Electrocardiographically Silent 60-Hz Intracardiac Leakage Current: Implications for Electrical Safety", Circulation, 99: 2559-2564, 1999.426Talit et al. "The Effect of External Cardiac Pacing on Stroke Volume", pace, 13(5): 598-602, 1990, Abstract.427Talit et al. "The Effect of External Cardiac Pacing on Stroke Volume", PACE, 13: 598-602, 1990.428Taniguchi et al. "Inhomogeneity of Cellular Activation Time and Vmax in Normal Myocardial Tissue Under Electrical Field Stimulation", Am. J. Physiol., 267: H694-H705, 1994, Abstract.429Taniguchi et al. "Inhomogeneity of Cellular Activation Time and VMax in Normal Myocardial Tissue Under Electrical Field Stimulation", American Journal of Physiology, 267: H694-H705, 1994.430Thakor et al. "Effect of Varying Pacing Waveform Shapes on Propagation and Hemodynamics in the Rabbit Heart", The Americal Journal of Cardiology, 79(6A): 36-43, 1997, Abstract.431Thakor et al. "Effect of Varying Pacing Waveform Shapes on Propagation and Hemodynamics in the Rabbit Heart", American Journal of Cardiology, 79(6A): 36-43, 1997.432Todd et al. "Subcutaneous Glucagon-Like Peptide I Improves Postprandial Glycaemic Control Over a 3-Week Period in Patients With Early Type 2 Diabetes", Clinical Science, 95: 325-329, 1998.433Translation of Decision of Rejection Dated Apr. 22, 2009 From the Japanese Patent Office Re.: Application No. 2004-534013.434Translation of Notice of Reasons for Rejection Dated Apr. 27, 2010 From the Japanese Patent Office Re.: Application No. 2007-206282.435Translation of Notice of Reasons for Rejection Dated Jul. 18, 2006 From the Japanese Patent Office Re.: Application No. 09-529637.436Translation of Notice of Reasons for Rejection Dated Jul. 18, 2006 From the Japanese Patent Office Re.: Application No. 9-529637.437Translation of Notification of Reasons of Rejection Dated Apr. 12, 2010 From the Japanese Patent Office Re.: Application No. 2006-525265.438Translation of Office Action Dated Apr. 20, 2011 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5.439Translation of Office Action Dated Aug. 3, 2011 From the State Intellectual Property Office (SIPO) of the People's Republic of China Re.: Application No. 200480012687.5.440Translation of Office Action Dated Sep. 12, 2008 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 200480032636.9.441Tsong "Electroporation of Cell Membranes", Biophysical Journal, 60: 297-306, 1991.442U.S. Appl. No. 90/008,688, filed Jun. 15, 2007, Ben Haim.443U.S. Appl. No. 90/008,689, Ben Haim.444U.S. Appl. No. 90/008,707, field Jun. 7, 2007, Ben Haim.445U.S. Appl. No. 95/000,032, Ben Haim.446USPTO Public Print Out of Interference File Content of Interference Dated Apr. 4, 2011 From the US Patent and Trademark Office Re. Interference No. 105,765.447USPTO Public Print Out of Interference File Content of Interference Dated Apr. 4, 2011 From the US Patent and Trademark Office Re. Interference No. 105,768.448Valdeolmillos et al. "In Vivo Synchronous Membrane Potential Oscillations in Mouse Pancreatic Beta-Cells: Lack of Co-Ordination Between Islets", Journal of Physiology, 493(1): 9-18, 1996.449Van Riper et al. "Electrical Field Stimulation-Mediated Relaxation of a Rabbit Middle Cerebral Artery. Evidence of a Cholinergic Endothelium-Dependent Component", Circulation Research, 70(6): 1104-1112, Jun. 1992.450Van Ripper et al. "Electrical Field Stimulation�Mediated Relaxation of a Rabbit Middle Cerebral Artery", Circulation Research, 70: 1104-1112, 1992.451Verrier et al. "Electrophysiologic Basis for T Wave Alternans as an Index of Vulnerability to Ventricular Fibrillation", Journal of Cardiovascular Electrophysiology, 5(5): 445-461, 1994. Abstract.452Wang et al. "Islet Amyloid Polypeptide Tonally Inhibits Beta-, Alpha-, and Delta-Cell Secretion in Isolated Rat Pancreatic Islets", American Journal of Physiology, AJP�Endocrinology and Metabolism, 276(1 Pt.1): E19-E24, 1999.453Wang et al. "Islet Amyloid Polypeptide Tonally Inhibits Beta-, Alpha-, and Gamma-Cell Secretion in Isolated Rat Pancreatic Islets", American Journal of Physiology, 276(1 Pt 1): E19-E24, 1999.454Wang et al. "Islet Amyloid Polypeptide Tonally Inhibits β-, α-, and δ-Cell Secretion in Isolated Rat Pancreatic Islets", American Journal of Physiology, AJP�Endocrinology and Metabolism, 276(1 Pt.1): E19-E24, 1999.455Webster "Electrodes, Leads, and Biocompatibility", Design of Cardiac Pacemakers, IEEE Press, p. 141-144, 1995.456Webster Design of Cardiac Pacemakers, IEEE Press, p. xi-xiii, 1995.457Wessale et al. "Stroke Volume and the Three Phase Cardiac Output Rate Relationship With Ventricular Pacing", PACE, 13: 673-680, 1990.458West "The Endocrine Pancreas", Best and Taylor's Physiological Basis of Medical Practice, 12th Ed.(Chap.50): 754-769.459Windle et al. "Subthreshold Conditioning Stimuli Prolong Human Ventricular Refractoriness", Am. J. Cardiol., 57(6): 381-386, 1986, Abstract.460Windle et al. "Subthreshold Conditioning Stimuli Prolong Human Ventricular Refractoriness", American Journal of Cardiology, 57(6): 381-386, 1986. Abstract.461Wirtzfeld et al. "Physiological Pacing: Present Status and Future Developments", Pace, 10(Part I): 41-57, 1987. Abstract.462Wirtzfeld et al. "Physiological Pacing: Present Status and Future Developments", PACE, 10(Pt.I): 41-57, 1987.463Wright et al. "Structure of Fab hGR-2 F6, a Competitive Antagonist of the Glucagon Receptor", Acta Crystallographica, Section D, Biological Crystallography, 56(Pt.5): 573-580, May 2000. Abstract.464Wright et al. Structure of Fab hGR-2F6, A Competitive Antagonist of the Glucagon Receptor, Acta Crystallographica, Section D Biological Crystallography, 56(Pt 1): 573-580, 2000.465Xue et al. "Neural-Network-Based Adaptive Matched Filtering for QRS Detection", IEEE Transactions on Biomedical Engineering, 39(4): 317-329, 1992, Abstract.466Yokoyama "The Phase of Supernormal Excitation in Relation to the Strength of Subthreshold Stimuli", Japanese Heart Journal, 17(3): 315-325, 1975.467Yokoyama "The Phase of Supernormal Excitation in Relation to the Strength of Subthreshold Stimuli", Japanese Heart Journal, 17(3): 315-325, May 1976.468Yonemura et al. "Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-Ribose) Synthetase Inhibitors. Evidence of Islet B-Cell Regeneration", Diabetes, 33(4): 401-404, 1984.469Yonemura et al. "Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-Ribose) Synthetase Inhibitors. Evidence of Islet B-Cell Regeneration", Diabetes, 33(4): 401-404, Apr. 1984. Abstract.470Zhou et al. "Prevention of Action Potentials During Extracellular Electrical Stimulation of Long Duration", Journal of Cardiovascular & Electrophysiology, 8(7): 779-789, 1997. Abstract.471Zhou et al. "Prevention of Action Potentials During Extracellular Electrical Stimulation of Long Duration", Journal of Cardiovascular Electrophysiology, 8: 779-789, 1997. Abstract.472Zipes et al. "Cardiac Electrophysiology-From Cell to Bedside", Saunders Co., 4th Ed., 1990.473Zipes et al. "Cardiac Electrophysiology�From Cell to Bedside", Saunders Co., 4th Ed., 1990.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS8828201 *Jul 1, 2010Sep 9, 2014Dexcom, Inc.Analyte sensors and methods of manufacturing sameUS20110027127 *Jul 1, 2010Feb 3, 2011Dexcom, Inc.Analyte sensors and methods of manufacturing same* Cited by examinerClassifications U.S. Classification607/116, 600/375, 600/386, 600/377, 607/133, 607/2, 600/372, 600/373, 600/300, 607/1, 607/40, 607/115International ClassificationA61N1/05Cooperative ClassificationA61N1/05European ClassificationA61N1/05Legal EventsDateCodeEventDescriptionJan 22, 2008ASAssignmentOwner name: METACURE LIMITED, BERMUDAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SPEHR, PAUL RICHARD;LEVI, TAMIR;ROUSSO, BENNY;REEL/FRAME:020394/0235;SIGNING DATES FROM 20070809 TO 20070830Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SPEHR, PAUL RICHARD;LEVI, TAMIR;ROUSSO, BENNY;SIGNING DATES FROM 20070809 TO 20070830;REEL/FRAME:020394/0235Owner name: METACURE LIMITED, BERMUDAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SPEHR, PAUL RICHARD;LEVI, TAMIR;ROUSSO, BENNY;SIGNING DATES FROM 20070809 TO 20070830;REEL/FRAME:020394/0235RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services