Source: http://www.google.com/patents/US5874095?dq=5920316
Timestamp: 2017-05-28 15:55:47
Document Index: 664345428

Matched Legal Cases: ['application No. 07', 'application No. 07', 'application No. 07', 'application No. 07', 'application No. 07', 'application No. 07', 'application No. 08', 'application No. 08', 'application No. 08']

Patent US5874095 - Enhanced skin penetration system for improved topical delivery of drugs - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular wight of from about 1,000,000 to about 30,000,000....http://www.google.com/patents/US5874095?utm_source=gb-gplus-sharePatent US5874095 - Enhanced skin penetration system for improved topical delivery of drugsAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS5874095 APublication typeGrantApplication numberUS 09/049,367Publication dateFeb 23, 1999Filing dateMar 27, 1998Priority dateOct 16, 1991Fee statusLapsedAlso published asCA2120927A1, CN1072863A, DE69224294D1, DE69224294T2, EP0608320A1, EP0608320B1, US5756118, US5756119, US5773023, US5776485, US5780049, WO1993007902A1Publication number049367, 09049367, US 5874095 A, US 5874095A, US-A-5874095, US5874095 A, US5874095AInventorsGeorge Endel Deckner, Brian Scott LombardoOriginal AssigneeRichardson-Vicks Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (68), Non-Patent Citations (24), Referenced by (47), Classifications (42), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetEnhanced skin penetration system for improved topical delivery of drugs
US 5874095 AAbstract
1. A topical pharmaceutical composition having enhanced penetration through the skin, the composition being in gel emulsion form and comprising:(a) an aqueous carrier; a safe and effective amount of a pharmaceutical active selected from the group consisting of anti-acne drugs, non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, sunless tanning agents, wound healing agents, skin bleaching or lightening agents, antihistaminic drugs, antitussive drugs, antipruritic drugs, anticholinergic drugs, anti-emetic and antinauseant drugs, anorexic drugs, central stimulant drugs, antiarrhythmic drugs, β-adrenergic blocker drugs, cardiotonic drugs, antihypertensive drugs, diuretic drugs, vasodilator drugs, vasoconstrictor drugs, anti-ulcer drugs, anesthetic drugs, antidepressant drugs, tranquilizer and sedative drugs, antipsychotic drugs, antimicrobial drugs, antineoplastic drugs, antimalarial drugs, muscle relaxant drugs, antispasmodic drugs, antidiarrheal drugs, bone-active drugs, and mixtures thereof; and (c) from about 0.05% to about 5% of a non-ionic crosslinked polyacrylamide having a molecular weight of from about 1,000,000 to about 30,000,000, the polyacrylamide being predispersed in a water-immiscible oil containing a surfactant having an HLB of from about 7 to about 10. 2. The composition of claim 1 wherein said pharmaceutical active is a skin bleaching or lightening agent.
16. A topical pharmaceutical composition having enhanced penetration through the skin, the composition being in gel emulsion form and comprising:(a) an aqueous carrier; (b) a safe and effective amount of a pharmaceutical active selected from the group consisting of anti-acne drugs, non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, sunless tanning agents, wound healing agents, skin bleaching or lightening agents, antihistaminic drugs, antitussive drugs, antipruritic drugs, anticholinergic drugs, anti-emetic and antinauseant drugs, anorexic drugs, central stimulant drugs, antiarrhythmic drugs, β-adrenergic blocker drugs, cardiotonic drugs, antihypertensive drugs, diuretic drugs, vasodilator drugs, vasoconstrictor drugs, anti-ulcer drugs, anesthetic drugs, antidepressant drugs, tranquilizer and sedative drugs, antipsychotic drugs, antimicrobial drugs, antineoplastic drugs, antimalarial drugs, muscle relaxant drugs, antispasmodic drugs, antidiarrheal drugs, bone-active drugs, and mixtures thereof; and (c) from about 0.1% to about 10% of a non-ionic crosslinked polyacrylamide having a molecular weight of from about 1,000,000 to about 30,000,000, the polyacrylamide being predispersed in a water-immiscible oil containing a surfactant having an HLB of from about 7 to about 10. 17. The composition of claim 16, wherein the polyacrylamide is included in an amount of from about 0.1% to about 5% by weight.
______________________________________Ingredient       (% W/W)______________________________________Water, Purified  52.395Alcohol SDA 40   40.000Polyacrylamide andC13-14 Isoparaffin andLaureth-7        4.000Salicylic Acid   2.000Glycerin         1.000Aloe Vera Gel    0.500Menthol          0.100Disodium EDTA    0.005______________________________________
______________________________________Ingredient       (% W/W)______________________________________Water            86.5Urea             10.0Benzyl Alcohol   0.5Polyacrylamide andC13-14 Isoparaffin andLaureth-7        3.0______________________________________
______________________________________Ingredient       (% W/W)______________________________________Water            91.5Benzyl Alcohol   0.5Polyacrylamide andC13-14 Isoparaffin andLaureth-7        3.0Dihydroxyacetyone            3.0Glycerin         2.0______________________________________
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2011Lubrizol Advanced Materials, Inc.Hydroxyl-terminated thiocarbonate containing compounds, polymers, and copolymers, and polyurethanes and urethane acrylics made therefromEP2272884A2Jul 18, 2005Jan 12, 2011Lubrizol Advanced Materials, Inc.Hydroxyl-terminated thiocarbonate containing compounds, polymers, and copolymers, and polyurethanes and urethane acrylics made therefrom* Cited by examinerClassifications U.S. Classification424/401, 424/78.03, 424/78.05, 514/944, 424/78.02, 424/78.06, 424/487, 514/969, 514/938, 424/78.07International ClassificationA61K47/32, A61K45/08, A61Q19/04, A61K8/81, A61K8/35, A61Q19/00, A61K9/00, A61K8/368, A61K8/36, A61K9/113, A61K9/107, A61K31/78Cooperative ClassificationY10S514/946, Y10S514/969, Y10S514/938, Y10S514/944, A61K8/368, A61K8/8158, A61K8/36, A61Q19/04, A61K47/32, A61Q19/00, A61K8/35, A61K9/0014European ClassificationA61K8/35, A61K47/32, A61K9/00M3, A61Q19/04, A61K8/368, A61K8/81K6, A61Q19/00, A61K8/36Legal EventsDateCodeEventDescriptionAug 31, 1999CCCertificate of correctionJul 26, 2002FPAYFee paymentYear of fee payment: 4Sep 13, 2006REMIMaintenance fee reminder mailedFeb 23, 2007LAPSLapse for failure to pay maintenance feesApr 24, 2007FPExpired due to failure to pay maintenance feeEffective date: 20070223RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services