Source: http://www.google.com/patents/US8206751?dq=%22Meaning-based+advertising+and+document+relevance+determination%22
Timestamp: 2017-06-25 11:34:47
Document Index: 126225251

Matched Legal Cases: ['application No. 2003265617', 'Application No. 2', 'Application No. 2477245', 'Application No. 2537210', 'Application No. 03826969', 'Application No. 200680013663', 'Application No. 03804566', 'Application No. 03804566', 'application No. 584433', 'application No. 10', 'Application No. 20043661']

Patent US8206751 - Class of therapeutics that enhance small molecule diffusion - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe subject invention relates to novel compositions containing a diffusion enhancing compound and their use in treating a variety of disorders....http://www.google.com/patents/US8206751?utm_source=gb-gplus-sharePatent US8206751 - Class of therapeutics that enhance small molecule diffusionAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS8206751 B2Publication typeGrantApplication numberUS 12/289,713Publication dateJun 26, 2012Filing dateOct 31, 2008Priority dateOct 31, 2007Fee statusPaidAlso published asCA2703946A1, CN101878040A, EP2214714A1, EP2214714A4, US20090110746, US20130018014, WO2009058399A1Publication number12289713, 289713, US 8206751 B2, US 8206751B2, US-B2-8206751, US8206751 B2, US8206751B2InventorsJohn L. GainerOriginal AssigneeDiffusion Pharmaceuticals LlcExport CitationBiBTeX, EndNote, RefManPatent Citations (73), Non-Patent Citations (198), Referenced by (1), Classifications (18), Legal Events (2) External Links: USPTO, USPTO Assignment, EspacenetClass of therapeutics that enhance small molecule diffusion
US 8206751 B2Abstract
3. A method as in claim 1, wherein said administration is selected from the group consisting of nasal, parenteral, transdermal, intramuscular injection and oral delivery. Description
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS2175843Jun 19, 1937Oct 10, 1939Winthrop Chem Co IncPolyene carboxylic acids and esters and manufacture thereofUS2948748Nov 24, 1958Aug 9, 1960 Esters thereofUS3489806Jan 19, 1967Jan 13, 1970Hoffmann La RocheIsoprenoid compounds and a process for producing the sameUS3687990Jul 1, 1969Aug 29, 1972Hoffmann La RocheIsoprenoid compounds and a process for producing the sameUS3788468May 1, 1973Jan 29, 1974Univ VirginiaProcess for increasing oxygen diffusivityUS3853993Jun 28, 1973Dec 10, 1974Univ VirginiaProcess for increasing oxygen diffusivity and method for treating atherosclerosisUS3965261Apr 29, 1975Jun 22, 1976University Of VirginiaMethod for treating papillomasUS3975519Jun 9, 1975Aug 17, 1976University Of VirginiaMethod for increasing the oxygen partial pressure in the bloodstream of mammalsUS4009270Nov 21, 1975Feb 22, 1977The University Of VirginiaMethod for treating spinal cord injuryUS4038144Apr 19, 1976Jul 26, 1977The University Of VirginiaMethod of increasing fermentation yieldsUS4046880Apr 20, 1976Sep 6, 1977The University Of VirginiaMethod of treating hypertensionUS4070460Nov 10, 1975Jan 24, 1978University Of Virginia Patents FoundationMethod for treating cerebral edemaUS4099270Feb 16, 1977Jul 11, 1978Jabour Richard JSlip-on rubber glovesUS4105855Jan 26, 1976Aug 8, 1978Basf AktiengesellschaftManufacture of symmetrical carotenoidsUS4176179Apr 17, 1978Nov 27, 1979The University Of Virginia Alumni Patents FoundationMethod for treating arthritisUS4216211Oct 31, 1977Aug 5, 1980The Procter & Gamble CompanyTherapeutic compositionUS4699664May 1, 1985Oct 13, 1987Nestec S.A.Stabilized natural pigment complexesUS5053240Oct 24, 1989Oct 1, 1991Kalamazoo Holdings, Inc.Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharidesUS5107030Mar 4, 1991Apr 21, 1992Loyola University Of ChicagoMethod of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereofUS5424407Nov 22, 1993Jun 13, 1995Ensuiko Sugar Refining Co., Ltd.Crocetin-containing coloringUS5472946Aug 6, 1993Dec 5, 1995Peck; James V.Transdermal penetration enhancersUS5811119Oct 22, 1996Sep 22, 1998Board Of Regents, The University Of TexasFormulation and use of carotenoids in treatment of cancerUS5817332Jun 20, 1995Oct 6, 1998Urtti; Arto O.Transdermal drug delivery systemUS6060511Oct 3, 1996May 9, 2000Gainer; John L.Trans-sodium crocetinate, methods of making and methods of use thereofUS6150561Sep 4, 1998Nov 21, 2000Roche Vitamins Inc.Method of making carotenoidsUS7145025Jul 29, 2003Dec 5, 2006Hawaii Biotech, Inc.Structural carotenoid analogs for the inhibition and amelioration of diseaseUS7446101Dec 12, 2003Nov 4, 2008Bioactives, LlcBioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systemsUS20020055486Aug 30, 2001May 9, 2002Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoPharmaceutical composition for ophthalmic useUS20030180282Mar 25, 2002Sep 25, 2003Victor SerebruanyMethod of treatment of thrombotic eventsUS20030186931Mar 24, 2003Oct 2, 2003Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoPharmaceutical composition for ophtalmic useUS20040109920Dec 4, 2002Jun 10, 2004Bioactives LlcCoated carotenoid cyclodextrin complexesUS20040116729Aug 25, 2003Jun 17, 2004Diffusion Pharmaceuticals LlcBipolar trans carotenoid salts and their usesUS20060194973 *Feb 24, 2006Aug 31, 2006Diffusion Pharmaceuticals LlcTrans carotenoids, their synthesis, formulation and usesUS20060276372Mar 9, 2006Dec 7, 2006Lockwood Samuel FCarotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disordersUS20070088248Sep 5, 2006Apr 19, 2007Iomai CorporationDevices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereofUS20080113031Sep 27, 2005May 15, 2008Joey MoodleyMinicapsule FormulationsUS20080255246Apr 11, 2008Oct 16, 2008Diffusion Pharmaceuticals LlcUse of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular diseaseUS20090110746Oct 31, 2008Apr 30, 2009Diffusion Pharmaceuticals LlcNew class of therapeutics that enhance small modecule diffusionUS20090169586Mar 24, 2006Jul 2, 2009Ian Simon TractonStable packaged dosage form and process thereforUS20090176287Feb 24, 2006Jul 9, 2009Regents Of The University Of MinnesotaProducing carotenoidsCH522572A Title not availableEP0908449A1Sep 28, 1998Apr 14, 1999F. Hoffmann-La Roche AgPreparation of carotenoidsEP1192947A1Aug 30, 2001Apr 3, 2002Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoPharmaceutical composition comprising trehalose for ophthalmic useJP2002524535A Title not availableJPH0326607A Title not availableJPH0356412A Title not availableJPH0532531A Title not availableJPH0723736A Title not availableJPH04264020A Title not availableJPH05178765A Title not availableJPH06248193A Title not availableJPH07223960A Title not availableJPH07291854A Title not availableJPH10502388A Title not availableJPH11180901A Title not availableJPH11209642A Title not availableJPS4514114B1 Title not availableJPS6359831A Title not availableJPS61254161A Title not availableKR19990036861A Title not availableWO1992015544A1Feb 25, 1992Sep 17, 1992Loyola University Of ChicagoMethod of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereofWO1995000130A1Jun 28, 1994Jan 5, 1995The Howard FoundationUse of hydrophilic carotenoids for the manufacture of a medicament for the treatment of diseases having an oxygenation mechanismWO1998014183A1Oct 2, 1997Apr 9, 1998The University Of Virginia Patent FoundationTrans-sodium crocetinate, methods of making and methods of use thereofWO1999015150A1Sep 22, 1998Apr 1, 1999Buford Biomedical, Inc.Inorganic-polymer complexes for the controlled release of compounds including medicinalsWO2000015262A1Sep 13, 1999Mar 23, 2000Inhale Therapeutic Systems, Inc.Dry powder active agent pulmonary deliveryWO2003072734A2Feb 25, 2003Sep 4, 2003Diffusion Pharmaceuticals LlcBipolar trans carotenoid salts and their usesWO2004048323A1Nov 17, 2003Jun 10, 2004Basf AktiengesellschaftMethod for producing carotenoidsWO2004049095A2Nov 25, 2002Jun 10, 2004Jallal MessadekBetaine and salicylic acid compositionsWO2005028411A1Aug 25, 2003Mar 31, 2005Diffusion Pharmaceuticals LlcBipolar trans carotenoid salts and their usesWO2005120495A1Jun 7, 2005Dec 22, 2005Salama Zoser BAnti-cancer composition comprising proline or its derivatives and an anti-tumour antibodyWO2006039685A2Oct 3, 2005Apr 13, 2006Hawaii Biotech, Inc.Methods for synthesis of chiral intermediates of carotenoids, carotenoid analogs, and carotenoid derivativesWO2006104610A2Feb 24, 2006Oct 5, 2006Diffusion Pharmaceuticals LlcTrans carotenoids, their synthesis, formulation and usesWO2007072529A2Dec 4, 2006Jun 28, 2007F.I.S. Fabbrica Italiana Sintetici S.P.A.Process for the synthesis of intermediates for the preparation of astaxanthin* Cited by examinerNon-Patent CitationsReference1Ahmad, A.S., et al, Pharmacology Biochemistry and Behavior, 81 (2005) pp. 805-813, "Neuroprotection by cretin in a hemi-parkinsonian rat model."2Australian Office Action dated Mar. 26, 2010 in applicant's Australian application No. 2003265617.3Bennett, MH, et al, Hyperbaric oxygen therapy for late radiation tissue injury (Review), Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Issue 2.4Britton, G. et al, Carotenoids, vol. 1A, Birkhauser-Verlag, Basel, 1995, p. 7, 35.5Buchta and Andree, Naturwiss, The Total Synthesis of trans-2,2-Bisdimethyl-crocetin-dimetyl ester and trans-Crocetin-dimethyl ester, (1959).6Buchta, E. and Andree, F., Chem. Ber. 93, 1349 (1960).7Bui, Q-C, et al, Int. J. Radiation Oncology Biol. Phys., vol. 60, No. 3, pp. 871-878, (2004), "The Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Radiation-Induced Late Side Effects."8Calvo, W., et al, The British Journal of Radiology, 61, pp. 1043-1052, (1988), "Time- and dose-related changes in the white matter of the rat brain after single doses of X rays."9Canadian Office Action dated Jul. 5, 2011.10Canadian Office Action dated Oct. 20, 2009 from Canadian Application No. 2,477,245.11Canadian Office Action issued Jul. 7, 2010 in corresponding Canadian Application No. 2477245.12Canadian Office Action issued Oct. 26, 2010 in corresponding Canadian Application No. 2537210.13Carotenoids vol. 1A: Isolation and Analysis, Edited by G. Britton, S. Liaaen-Jensen and H. Pfander, Birkhauser Verlag, Basel, 1995, pp. 103-107; p. 283.14Chem. Abstr. of JP 05032531.15Chinese Office Action and its English Translation dated Feb. 12, 2010 in the Assignee's Chinese application relating to PCT/US 06/06422.16Chinese Office Action and its English Translation dated Feb. 21, 2011 in the Assignee's Chinese application relating to PCT/US 06/06422.17Chinese Office Action dated Mar. 29, 2010 from Chinese Patent Application No. 03826969.4 based on PCT/US03/26424.18Chinese Office Action dated Nov. 7, 2008 in a corresponding application owned by the applicants (Chinese App No. 03826969.4).19Chinese Patent Office Action (English translation) dated Jun. 30, 2011.20Chinese Patent Office Action dated Apr. 6, 2011, and English translation.21Chinese Patent Office Action dated Apr. 6, 2011, from Chinese Patent Application No. 200680013663.0 based on PCT/US2006/06422, and its English translation.22Chinese Patent Office-Third Office Action in Chinese Patent Application No. 03804566.4 dated Jan. 23, 2009.23Chinese Patent Office—Third Office Action in Chinese Patent Application No. 03804566.4 dated Jan. 23, 2009.24Cianci, P, (see Cianci, P., Hyperbaric therapy for radiation injury, in "Radiation Injury, Advances in Management and Prevention" edited by J.L. Meyer, et al, pp. 98-109, (1999)).25Coppola, G.M., Syn. Communications 1021 (Dec. 1984).26Craw, M., et al, Photochemitry and Photobiology, vol. 38 (2), 241-243 (1983).27CRC Handbook of Chemistry and Physics, edited by D.R. Lide, PH.D., CRC Press, Boca Raton, FL, 6-181, 1998.28Cutright, D.E., et al, Radiation Research, 48, pp. 402-408 (1971) "Long-Term Effects of Radiation on the Vascularity of Rat Bone-Quantitative Measurements with a New Technique."29Cutright, D.E., et al, Radiation Research, 48, pp. 402-408 (1971) "Long-Term Effects of Radiation on the Vascularity of Rat Bone—Quantitative Measurements with a New Technique."30Database Caplus (Chem. Abs. Service, USA) acc. Nr. 1989:211328.31Database Caplus Chemical Abstracts Service, Columbus, Ohio (XP002317165).32Database Caplus Chemical Abstracts Service, Columbus, Ohio (XP002317166).33Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; (XP002317165) [JP 63 059831].34Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; (XP002317166) [JP 05 032531].35Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; XP002317165 [Japan 63 059831].36Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; XP002317165 [JP 63 059831].37Database Caplus, Chemical Abstracts Service, Columbus, Ohio, US; XP002317166 [Japan 05 032531].38Database HCAPLUS on STN, DN 141:388250, Magesh, V. "Studies on the anti-tumor effect of crocetin against benzo(a)pyrene induced lung cancer in Swiss albino mice." Biomedicine, (CHennai, India) (2003), 23 (3 & 4), 96-99, Abstract.39Denninghoff et al, Diabetes Technology & Therapeutics, vol. 2, No. 1, pp. 111-113 (2000).40E. Wenkert et al, J. Org. Chem., vol. 55, No. 25, 6203-6214 (1990); XP-002317164.41EP Office Action dated Apr. 7, 2011, from European Patent Application No. EP 08742781.1.42EPO Office Action dated Nov. 9, 2009 in applicant's European application corresponding to PCT/US03/05521.43EPO Office Action dated Nov. 9, 2009 in applicant's European application corresponding to PCT/US03/26424.44Eurasian Patent Office Action (English translation) dated Nov. 9, 2011.45European Patent Office Action dated Oct. 31, 2011, from European Patent Application No. EP 06758166.0.46Examination Report dated Apr. 12, 2010 issued by the India Patent Office in one of Applicants' corresponding foreign applications.47Examination Report dated Apr. 7, 2010 issued by the New Zealand Patent Office in Applicants' corresponding foreign application No. 584433.48Examination Report dated Jan. 8, 2008 from corresponding New Zealand Patent Office.49Examination Report dated Jul. 2, 2009 issued by the New Zealand Patent Office in one of Applicants' corresponding foreign applications.50Examination Report dated Oct. 25, 2010 issued by the Australian Patent Office in one of Applicants' corresponding foreign applications.51Examination Report dated Oct. 6, 2008 issued by the New Zealand Patent Office in one of Applicants' corresponding foreign applications.52Examination Report dated Oct. 7, 2010 issued by the New Zealand Patent Office in one of Applicants' corresponding foreign applications.53Gainer, J.L., et al, Atherosclerosis, 19: 135-138, 1974, "Oxygen diffusion and atherosclerosis."54Gainer, J.L., et al, Chem. Eng. Commun., 15, pp. 323-329, 1982 "Using Excess Volume of Mixing to Correlate Diffusivities in Liquids."55Gainer, J.L., et al, Circulatory Shock, 41, pp. 1-7, (1993), "The Effect of Crocetin on Hemorrhagic Shock in Rats."56Gainer, J.L., et al, Pulmonary Pharmacology & Therapeutics, 18, pp. 213-216, (2005), "The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury."57Gainer, J.L., et al, Pulmonary Pharmacology & Therapeutics, 18, pp. 213-216, 2005, "The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury."58Gainer, J.L., Ind. Engr. Chem. Research, vol. 33, pp. 2341-2344, 1994 "Altering Diffusivities in Dilute Polymeric and Biological Solutions."59Giassi, L.J., et al, Journal of Trauma, 51, pp. 932-938, (2001), "Trans-Sodium Crocetinate Restores Blood Pressure, Heart Rate, and Plasma Lactate after Hemorrhagic Shock."60Giassi, L.J., et al, Journal of Trauma, 51:932-938, 2001, "Trans Sodium Crocetinate Restores Blood Pressure, Heart Rate, and Plasma Lactate after Hemorrhagic Shock."61Giassi, L.J., et al, Shock, 18(6), pp. 585-588 (2002), "Trans Sodium Crocetinate for Hemorrhagic Shock: Effect of Time Delay in Initiating Therapy."62Gibson, T.W., et al, J. Org. Chem., vol. 41, No. 5, 1976, pp. 791-793 (XP002325593).63Gibson, T.W., et al, J. Org. Chem., vol. 41, No. 5, 1976, pp. 791-793, (XP002325593).64Gill, A.L., et al, Q J Med, 97, pp. 385-395, (2004), "Hyperbaric oxygen: its uses, mechanisms of action and outcomes."65Goldstick, T.K., PhD Dissertation, University of California, Berkeley, CA, pp. 13-28, 1996, "Diffusion of Oxygen in Protein Solutions."66Gree, R., et al, Tetrahedron Letters, 27, 4983 (1986).67Greenwood, T.W., et al, Brit. J. Surg., vol. 60, No. 5, May 1973, pp. 394-397, "Hyperbaric Oxygen and Wound Healing in Post-Irradiation Head and Neck Surgery."68Holland, R.A.B., et al, Respiration Physiology, 59, pp. 71-91, 1985, "Kinetics of O2 Uptake and Release by Red Cells in Stopped-Flow Apparatus: Effects of unstirred Layer."69Holloway, G.M., et al, The American Physiological Society, 1988, pp. 683-686-Department of Chemical Engineering, and Dept. of Anesthesiology, School of Medicine, Univ. of VA, Charlotteville, Va; "The carotenoid crocetin enhances pulmonary oxygenation."70Holloway, G.M., et al, The American Physiological Society, 1988, pp. 683-686—Department of Chemical Engineering, and Dept. of Anesthesiology, School of Medicine, Univ. of VA, Charlotteville, Va; "The carotenoid crocetin enhances pulmonary oxygenation."71Hungarian Novelty Search Report dated Nov. 5, 2009 (w/translation).72Huxley, V.H., et al, J. Physiol., 316, pp. 75-83, (1981), "The Effect of the Red Cell Membrane and a Diffusion Boundary Layer on the Rate of Oxygen Uptake by Human Erythrocytes."73Huxley, V.H., et al, J. Physiol., 316, pp. 75-83, 1981, "The Effect of the Red Cell Membrane and a Diffusion Boundary Layer on the Rate of Oxygen Uptake by Human Erythrocytes."74India Office Action dated Oct. 23, 2008 in a corresponding application owned by the applicants (India Patent App No. 676/DELNP/2006).75International Preliminary Examination Report dated May 25, 2007.76International Preliminary Report on Patentability, dated May 4, 2010.77International Preliminary Report on Patentability—issued Oct. 13, 2009 in PCT/US2008/004708.78International Search Report and Written Opinion mailed Jul. 22, 2008.79International Search Report and Written Opinion mailed Oct. 19, 2006 in PCT/US06/06422.80International Search Report dated Mar. 25, 2009 in PCT/US 08/12440.81International Search Report dated Sep. 1, 2010 in PCT/US 10/01794.82International Search Report dated Sep. 9, 2011 in PCT/US 11/00997.83International Search Report Dec. 24, 2003.84International Searching Authority Invitation dated Jan. 13, 2009 in PCT/US 08/12440.85IPRP issued in corresponding PCT Appln. No. PCT/US2008/004708.86Isler, O., et al, Helv. Chim. Acta, vol. 40, No. 5, 1957, pp. 1242-1249 (XP008042920).87Isler, O., et al, Helv. Chim. Acta, vol. 40, No. 5, 1957, pp. 1242-1249, (XP008042920).88Isler, O., et al, Helv. Chim. Acta, vol. 40, No. 5, 1957, pp. 1242-1249.89Isler, O., et al, Helv. Chim. Acta., vol. 40, No. 5, 1957, pp. 1242-1249.90Jansen, F.J.H.M., et al, Recl. Trav. Chem. Pays-Bas, 113, 552 (1994).91Japanese Notice of Reasons for Rejection and its English Translation dated May 24, 2011.92Japanese Office Action and its English Translation dated Apr. 6, 2010 in the Assignee's Japanese application relating to PCT/US2006/006422.93Japanese Office Action and its English Translation dated Jan. 12, 2010 in the Assignee's Japanese application relating to PCT/US 03/26424.94Japanese Office Action mailed Oct. 4, 2011, and English translation.95Japanese Patent Office Action dated Jun. 2, 2009 and its English translation, cited in one of Assignee's Japanese patent applications (No. 2003-571422).96Japanese Patent Office Action dated Jun. 2, 2009 and its English translation, cited in one of Assignee's Japanese patent applications.97Johnson et al, Journal of Pharmaceutical Science, vol. 85, No. 7, 1996, pp. 670-679, "Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery."98Johnson, et al, Journal of Pharmaceutical Sciences, vol. 85, No. 7, 1996, pp. 670-679, "Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery."99Johnson, M.E., et al, Journal of Pharmaceutical Sciences, vol. 85, No. 7, pp. 670-679, Jul. 1996, "Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery."100Johnson, Mark E, et al, Journal of Pharmaceutical Sciences, vol. 85, No. 7, Jul. 1996, pp. 670-679, entitled "Synergistic Effects of Chemical Enhancers and Therapeutic Ultrasound on Transdermal Drug Delivery."101Kalani, M., et al, Journal of Diabetes & Its Complications, vol. 16, No. 2, pp. 153-158 (2002).102Kamiro, T., et al, Neurosurgery, vol. 49, No. 2, pp. 409-415, Aug. 2001, "Radiosurgery-induced Microvascular Alterations Precede Necrosis of the Brain Neuropil."103Kamiryo, T., et al, Acta Neurochir (Wien), 138, pp. 451-459, (1996), "Histological Changes in the Normal Rat Brain After Gamma Irradiation."104Korean Office Action and its English Translation dated Jul. 6, 2010 in the Assignee's Korean application 10-2004-7013118, that is the nationalized appln. from PCT/US03/05521, claiming priority from U.S. Appl. No. 60/358,718.105Korean Office Action and its English Translation dated Jun. 22, 2010 from applicant's Korean Patent Appln. No. 10-2006-7003827, that corresponds to PCT/US03/26424.106Korean Office Action dated May 26, 2009, and English translation in a corresponding application owned by the applicants.107Korean Office Action dated Nov. 23, 2009 in applicant's corresponding Korean application No. 10-2006-7003827.108Ladig et al, J. Am. Chem. Soc., 120, 9394-9395 (1998).109Ladig, K.E., et al, JACS, vol. 120, No. 36, 1998, pp. 9394-9395 (XP 002970835).110Ladig, K.E., et al, Journal of the American Chemical Society, vol. 120, No. 36, pp. 9394-9396, (1998), "Altering Diffusivity in Biological Solutions through Modification of Solution Structure and Dynamics."111Laidig, K. E., et al, Journal of the American Chemical Society, vol. 120, No. 36, pp. 9394-9395, 1998, "Altering Diffusivity in Biological Solutions through Modification of Solution Structure and Dynamics."112Laidig, K.E. et al, Altering Diffusivity in Biological Solutions through Modification of Solution Structure and Dynamics, Journal of the American Chemical Society, 1998, vol. 120, No. 36, pp. 9394-9395.113Letham, D.S., et al Phytochemistry 10, 2077 (1971).114Lyubimova, N., et al, The British Journal of Radiology, 77, pp. 488-492, (2004), "Experimental evidence to support the hypothesis that damage to vascular endothelium plays the primary role in the development of late radiation-induced CNS injury."115Marx, R.E., DDS, J. Oral Maxillofac Surg, 41, pp. 283-288, (1983), "Osteoradionecrosis: A New Concept of its Pathophysiology."116Marx, R.E., et al, The American Journal of Surgery, vol. 160, pp. 519-524, Nov. 1990, "Relationship of Oxygen Dose to Angiogenesis Induction in Irradiated Tissue."117Mayer, R., et al, Strahlenther Onkol, No. 2, pp. 113-123 (2005), "Hyperbaric Oxygen and Radiotherapy."118Mexican Office Action dated Feb. 23, 2009 in a corresponding application owned by the applicants (Mexican Patent App No. PA/a/2004/008253).119Mexican Office Action dated May 2010, and English translation of rejected parts of the Office Action, from Mexican Patent Application No. PA/a/2004/008253 corresponding to International Patent Application No. PCT/EP2003/005521.120Mexican Office Action dated Oct. 20, 2011 (with English translation).121Miyagawa, H., et al, Neuropathology, 16, pp. 126-132, (1996), "Pathogenesis of delayed radiation injury in the rat spinal cord after X-ray irradiation."122Moelbert, S., et al, Biophuysical Chemistry 112, 45-57, 2004 "Kosmotropes and chaotropes: modeling preferential exclusion, binding and aggregate stability."123New Zealand Office Action dated Jan. 21, 2011.124Nihon Butsuri Gakkai Shi, Journal of the Physical Society of Japan, 1995, 50(7), p. 555-561, "Structure and Function of Cartenoid in Photosynthetic System."125Norway Office Action dated Feb. 16, 2011, from Norway Patent Application No. 20043661, and its English translation.126Norwegian Office Action and its English Translation mailed Jun. 22, 2010 in the Assignee's Norwegian application relating to PCT/US03/05521.127Notification Concerning Transmittal of International Preliminary Report on Patentability (Chapter 1 of the Patent Cooperation Treaty), dated May 14, 2010.128O. Isler et al, Helv. Chim. Acta, vol. 40, No. 5, 1242-1249 (1957), XP008042920.129Office Action dated Dec. 19, 2011 from U.S. Appl. No. 12/801,726.130Office Action dated Dec. 4, 2008 from U.S. Appl. No. 11/361,054.131Office Action dated Jan. 4, 2012 from U.S. Appl. No. 13/137,337.132Office Action dated Jun. 25, 2008 from corresponding Australian Patent Office.133Office Action dated Nov. 13, 2008 from U.S. Appl. No. 10/647,132.134Office Action dated Oct. 28, 2009 from Application U.S. Appl. No. 11/361,054.135Office Action dated Sep. 22, 2011 from U.S. Appl. No. 11/790,779.136Office Action dated Sep. 28, 2007 from U.S. Appl. No. 11/723,383.137Office Action issued in Japanese Patent Appin. No. 2007-557157 and English translation (corresponding to PCT App. No. US 2006/006422) dated May 24, 2011.138Okeda, R., Neuropathology, 23, pp. 153-160, (2003), "Pathological changes in the cerebral medullary arteries of five autopsy cases of malignant nephrosclerosis: Observation by morphometry and reconstruction of serial sections."139Okonkwo, D.O., et al, Neuroscience Letters 352 (2003) 97-100, "Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation."140Okonkwo, D.O., et al, Neuroscience Letters, 352, pp. 97-100, (2003), "Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation."141Okonkwo, D.O., et al, Neuroscience Letters, 352, pp. 97-100, 2003, "Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation."142Pauling, L., Fortschr. Chem. Org. Naturst., 3:303 (1939), p. 203-235.143PCT Notification dated Mar. 25, 2009 in PCT/US 08/12440.144Pfander, H. et al, Pure & Appl. Chem., vol. 69, No. 10, pp. 2047-2060 (1997), "Carotenoid synthesis: A progress report."145Polish Office Action dated Feb. 23, 2010 from Polish Patent Application No. P-373780 based on PCT/US03/05521.146Polish Office Action dated Sep. 2010 in corresponding Polish Application No. P-373780.147Pure & Appl. Chem., vol. 69, No. 10, pp. 2047-2060, 1997, "Carotenoid synthesis: A progress report."148R. Wirz et al, Helv. Chim. Acta, vol. 43, No. 6, 1738-1745 (1960), XP008042762.149RN: 120523-11-7; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-potassium sodium salt.150RN: 147484-59-1; CN: 2,4,6,8-Decatetraenedioic acid, disodium salt.151RN: 33261-80-2; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-dipotassium salt.152RN: 33261-81-3; CN: 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-disodium salt.153Roy, et al, Shock, vol. 10, No. 3, pp. 213-217 (1998).154Roy, J.W., et al, Shock, vol. 10, No. 3, pp. 213-2171, (1998), "A Novel Fluid Resuscitation Therapy for Hemorrhagic Shock."155Schwieter, U., et al, "Synthesen in der Carotinoid-Reiche 20. Mitteilung Neu Synthesen von Apocarotinoiden," Helvetica Chimica Acta, vol. 1, (1966), pp. 369-390, XP-002575142.156Secor, R.M., A.I.Ch.E. Journal, vol. 11, No. 3, pp. 452-456, 1965, "The Effect of Concentration on Diffusion Coefficient in Polymer Solutions."157Seyde, Walter C., et al, Journal of Cerebral Blood Flow and Metabolism, vol. 6, No. 6, 1986, pp. 703-707, "Carotenoid Compound Crocetin Improves Cerebral Oxygenation in Hemorrhaged Rats."158Singer et al, Crit Care Med, vol. 28, No. 6, pp. 1968-1972 (2000) Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia.159Singer, M., et al, Crit Care Med, vol. 28, No. 6, pp. 1968-1972, (2000), "Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia."160Snyder, J.M., et al, J. Am. Oil Chem. Soc., 59, 469 (1982).161Stennett, A.K., et al, J. Phys. Chem. B., vol. 110, No. 37, pp. 18078-18080, 2006, "trans-Sodium Crocetinate and Diffusion Enhancement."162Supplementary European Search Report dated Apr. 29, 2010 issued by the EPO in one of Applicants' corresponding foreign applications.163Supplementary European Search Report dated Dec. 8, 2010 (corresponding to applicant's European Regional Phase Patent Application No. EP 08844993.9 based on International Patent Application No. PCT/US2008/012440 filed on Oct. 31, 2008).164Supplementary Partial European Search Report-Apr. 21, 2005.165Supplementary Partial European Search Report—Apr. 21, 2005.166Supplementary Partial European Search Report-Feb. 25, 2005.167Supplementary Partial European Search Report—Feb. 25, 2005.168T.W. Gibson et al, J. Org. Chem., vol. 41, No. 5, 791-793 (1976); XP-002325593.169U.S. Appl. No. 10/647,132, filed Aug. 2003, Gainer.170U.S. Appl. No. 11/361,054, filed Feb. 2006, Gainer.171U.S. Appl. No. 60/907,718, filed Apr. 2007, Gainer.172U.S. Appl. No. 60/907,718, filed Feb. 2007, Gainer.173U.S. Appl. No. 61/001,095, filed Oct. 2007, Gainer.174Ukraine Office Action issued Aug. 2010.175Wenkert, E. et al, Journal of Organic Chemistry, Dec. 7, 1990, Vo. 55, No. 25, pp. 6203-6214.176Wenkert, E., et al, J. Org. Chem., vol. 55(25), pp. 6203-6214, 1990, (XP002317164).177Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, p. 6203-6214 (XP002317164).178Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, pp. 6203-6214 (XP002317164).179Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, pp. 6203-6214, (XP002317164).180Wenkert, E., et al, J. Org. Chem., vol. 55, No. 25, 1990, pp. 6203-6214.181White, D.C., MD, Cancer, 37, pp. 1126-1143, February Supplement (1976), "The Histopathologic basis for functional decrements in late radiation injury in diverse organs."182Widmer, Erich et al, Helvetica Chemica Acta—vol. 73 (1990), pp. 861-867, Technical Procedures for the Syntheses of Carotenoids and Related Compounds . . . .183Wilkins, E.S., et al, Cancer Biochem. Biophys., 1979, vol. 3, pp. 71-74, "The Effect of Crocetin on the Irradiation of Walker-256: In Vitro and In Vivo Studies."184Williamson, et al, Int. J. Oral Maxillofac. Surg., 36, pp. 533-540, (2007), "An experimental study of the use of hyperbaric oxygen to reduce the side effects of radiation treatment for malignant disease."185Wirz, R. et al, Helvetica Chimica Acta, 1960, 43(6), 1738-1745.186Wirz, R., et al, Helv. Chim. Acta, vol. 43(6), pp. 1738-1745, 1960, (XP008042762).187Wirz, R., et al, Helv. Chim. Acta, vol. 43, No. 6, 1960, pp. 1738-1745, (XP008042762).188Wirz, R., et al, Helv. Chim. Acta, vol. 43, No. 6, 1960, pp. 1738-1745.189Wirz, R., et al, Helv.Chim.Acta, vol. 43, No. 6, 1960, pp. 1738-1745 (XP008042762).190Written Opinion and International Search Report issued in PCT/US06/06422 dated Oct. 19, 2006.191Written Opinion dated Mar. 25, 2009 in PCT/US 08/12440.192Written Opinion dated Mar. 25, 2009 in PCT/US2008/012440 [previously submitted].193Written Opinion dated Sep. 1, 2010 in PCT/US 10/01794.194Written Opinion dated Sep. 9, 2011 in PCT/US 11/00997.195Wurtman, R.J., Scientific American, vol. 252, 1985 Alzheimer's Disease.196Yamaguchi, K., et al, J. Applied Physiology, 58: 1215-1224, 1985.197Yamaguchi, K., et al, the American Physiological Society, pp. 1215-1224, (1985), "Kinetics of O2 uptake and release studied by human erythrocytes studied by a stopped-flow technique."198Zheng, S., et al, "Crocetin Attenuates Atherosclerosis in Hyperlipidemic Rabbits Through Inhibition of LDL Oxidation," Journal of Cardiovascular Pharmacology, vol. 47, No. 1, Jan. 2006, pp. 70-76, XP009135396, ISSN: 0160-2446.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS20130323166 *Mar 8, 2013Dec 5, 2013William Beaumont HospitalRadiation Therapy for Treating Alzheimer's Disease* Cited by examinerClassifications U.S. Classification424/601, 514/423, 514/551, 514/53, 514/547International ClassificationA61K33/42Cooperative ClassificationA61K31/232, A61K31/14, A61K31/7016, A61K33/42, A61K31/17, A61K31/401European ClassificationA61K31/14, A61K31/232, A61K31/17, A61K31/401, A61K31/7016, A61K33/42Legal EventsDateCodeEventDescriptionJan 7, 2009ASAssignmentOwner name: DIFFUSION PHARMACEUTICALS LLC, VIRGINIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GAINER, JOHN L.;REEL/FRAME:022094/0064Effective date: 20081117Nov 24, 2015FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services