Source: http://www.google.com/patents/US8086299?dq=6,073,142
Timestamp: 2014-07-12 17:27:11
Document Index: 634998009

Matched Legal Cases: ['Application No. 01', 'Application No. 01', 'Application No. 2007', 'Application No. 2007', 'Application No. 01', 'Application No. 01']

Patent US8086299 - Frameless radiosurgery treatment system and method - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsA method and apparatus for selectively and accurately localizing and treating a target within a patient are provided. A three dimensional mapping of a region surrounding the target is coupled to a surgical intervention. Two or more diagnostic beams at a known non-zero angle to one another may pass through...http://www.google.com/patents/US8086299?utm_source=gb-gplus-sharePatent US8086299 - Frameless radiosurgery treatment system and methodAdvanced Patent SearchPublication numberUS8086299 B2Publication typeGrantApplication numberUS 12/356,442Publication dateDec 27, 2011Filing dateJan 20, 2009Priority dateMar 16, 1999Also published asEP1328195A1, EP1328195A4, US6778850, US8634898, US20050027194, US20090129545, US20120078090, US20140107477, WO2002022019A1Publication number12356442, 356442, US 8086299 B2, US 8086299B2, US-B2-8086299, US8086299 B2, US8086299B2InventorsJohn R. Adler, Achim SchweikardOriginal AssigneeAccuray IncorporatedExport CitationBiBTeX, EndNote, RefManPatent Citations (65), Non-Patent Citations (13), Referenced by (1), Classifications (46) External Links: USPTO, USPTO Assignment, EspacenetFrameless radiosurgery treatment system and methodUS 8086299 B2Abstract A method and apparatus for selectively and accurately localizing and treating a target within a patient are provided. A three dimensional mapping of a region surrounding the target is coupled to a surgical intervention. Two or more diagnostic beams at a known non-zero angle to one another may pass through the mapping region to produce images of projections within the mapping region in order to accurately localize and treat the target wherein the images are captured using one or more image recorders.
1. A system for directing a treatment beam towards an internal target region in a patient, comprising:
a treatment bed configured to support the patient during a treatment;
a respiratory motion detection system configured to track a respiration cycle of the patient based on monitoring external patient motion;
one or more diagnostic beam generators configured to generate diagnostic beams directed towards the patient at one or more particular points of the respiration cycle during one or more occurrences of the respiration cycle, wherein the one or more particular points comprise less than an entirety of the respiration cycle, the one or more diagnostic beam generators being located at one or more predetermined positions, wherein at least one beam from the one or more diagnostic beam generators is at a predetermined non-zero angle with respect to additional beams of the one or more diagnostic beam generators;
an image recording device located opposite the one or more diagnostic beam generators configured to receive the diagnostic beams from the one or more diagnostic beam generators, wherein the image recording device is configured to capture intra-treatment images of the patient from the diagnostic beams;
a processor configured to compare the intra-treatment images to a pre-treatment image to determine a location of the internal target region at the one or more particular points of the respiration cycle; and
a treatment beam generator configured to energize the treatment beam at a distinct point of the respiration cycle during a distinct occurrence of the respiration cycle during the treatment.
2. The system of claim 1, wherein the one or more diagnostic beam generators comprise one or more x-ray beam generators.
3. The system of claim 1, wherein the image recording device comprises an amorphous silicon image recorder.
4. The system of claim 1, further comprising a linear accelerator to generate the treatment beam.
5. The system of claim 1, wherein the processor is further configured to deform the intra-treatment images or the pre-treatment image, wherein the deformed intra-treatment images or deformed pre-treatment image are adapted to improve a match between the intra-treatment images and the pre-treatment image.
6. The system of claim 1, wherein the processor is further configured to generate a 3D intra-treatment image from the intra-treatment images and to compare the 3D intra-treatment image to a 3D pre-treatment image of the patient generated prior to treatment to determine the location of the internal target region.
7. The system of claim 1, wherein the distinct point of the respiration cycle does not correspond to any of the one or more particular points of the respiration cycle, and wherein the distinct occurrence of the respiration cycle corresponds to one of the one or more occurrences of the respiration cycle.
adjusting a targeting of the treatment beam to compensate for changes in the location of the internal target region, wherein the changes are identified based on the comparison of the intra-treatment images to the pre-treatment image.
9. The system of claim 1, wherein the image recording device is located adjacent the treatment bed.
10. The system of claim 1, wherein the processor is further configured to generate a correlation between the one or more particular points of the respiration cycle and locations of the internal target region.
11. The system of claim 1, wherein the respiratory motion detection system tracks the respiration cycle based on tracking positions of external markers disposed on the patient, and wherein the processor is further configured to determine a correlation between the positions of the external markers and locations of the internal target region.
12. The system of claim 1, wherein the processor is further configured to verify a correlation model between the respiration cycle and the location of the internal target region.
13. The system of claim 1, wherein the distinct point of the respiration cycle corresponds to one of the one or more particular points of the respiration cycle, and wherein the distinct occurrence of the respiration cycle is a subsequent occurrence of the respiration cycle.
14. The system of claim 1, wherein the treatment beam generator is further configured to shut off the treatment beam at a subsequent point during the distinct occurrence of the respiration cycle.
15. A method for directing a treatment beam towards an internal target region in a patient, comprising:
monitoring external movement of the patient to identify a respiration cycle of the patient;
energizing one or more diagnostic beams from one or more positions at a particular point of the respiration cycle within a particular occurrence of the respiration cycle to determine a location of the internal target region during a treatment;
generating a correlation model between locations of the internal target region and one or more points of the respiration cycle; and
energizing the treatment beam over at least one of the particular point of the respiration cycle or an additional point of the respiration cycle during the particular occurrence of the respiration cycle or a subsequent occurrence of the respiration cycle based on the correlation model to treat the internal target region.
16. The method of claim 15, wherein locating the internal target region during treatment comprises:
comparing intra-treatment images generated from the one or more diagnostic beams to a 3D pre-treatment image of the patient generated prior to treatment to identify changes in the location of the internal target region.
deforming the intra-treatment images or the 3D pre-treatment image, wherein the deformed intra-treatment images or deformed 3D pre-treatment image are adapted to improve a match between the intra-treatment images and the 3D pre-treatment image.
adjusting a targeting of the treatment beam to compensate for the changes in the location of the internal target region.
19. The method of claim 15, wherein locating the internal target region during treatment comprises:
generating a 3D intra-treatment image from 2D intra-treatment images generated from the one or more diagnostic beams; and
comparing the 3D intra-treatment image to a 3D pre-treatment image of the patient generated prior to treatment.
energizing the treatment beam at the same particular point of the respiration cycle during a subsequent occurrence of the respiration cycle.
energizing an additional diagnostic beam from a new position that is different from the one or more positions so that the additional diagnostic beam passes through the internal target region at a predetermined non-zero angle with respect to the one or more diagnostic beams, wherein the additional diagnostic beam is energized at the particular point of the respiration cycle within an additional occurrence of the respiration cycle.
tracking the external movement of the patient by tracking the movement of one or more external markers by a tracking system.
23. An apparatus for directing a treatment beam towards an internal target region in a patient, comprising:
means for generating a three-dimensional image of the patient prior to the treatment;
means for determining a respiration cycle of the patient from external movement of the patient;
means for energizing one or more diagnostic beams at a particular point of the respiration cycle during a particular occurrence of the respiration cycle to determine a position of the internal target region during a treatment;
means for generating a correlation model between locations of the internal target region and one or more points of the respiration cycle; and
means for energizing the treatment beam over at least one of the particular point of the respiration cycle or an additional point of the respiration cycle during the particular occurrence of the respiration cycle or a subsequent occurrence of the respiration cycle based on the correlation model to treat the internal target region.
means for comparing images derived from the one or more diagnostic beams to the three-dimensional image to determine the position of the internal target region at the point of the respiration cycle; and
means for adjusting a targeting of the treatment beam in response to the comparison of the three-dimensional image and the images derived from the one or more diagnostic beams.
25. The apparatus of claim 23, wherein the means for adjusting further comprises a computer-controlled robot for positioning the treatment beam. Description
REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser. No. 10/919,765 filed Aug. 17, 2004 now abandoned, which is a continuation of U.S. application Ser. No. 09/663,104, filed Sep. 15, 2000, U.S. Pat. No. 6,778,850, which is a continuation-in-part of U.S. application Ser. No. 09/270,404, filed Mar. 16, 1999, U.S. Pat. No. 6,144,875, which are incorporated herein by reference.
In order to control a surgical procedure, such as radiosurgery, many different prior techniques have been used including the manual targeting of the treatment. Many of the prior techniques are not sufficiently accurate so that healthy tissue surrounding the target region is often unnecessarily irradiated and damaged or killed. Other techniques are clumsy and cannot be used for particular types of treatments. For example, one prior technique involved frame-based stereotaxy that was often used for body parts and regions that could be easily physically immobilized. For example, the frame based stereotaxy was often used to immobilize the head of the patient so that a target region in the brain, such as a brain tumor, could be irradiated by the radiosurgical beam. To do so, the patient was positioned on a treatment bed and then his/her head was immobilized by a frame that was securely attached to the person's head with some attachment means and that was also securely attached to an immovable object such as a treatment table. Thus, during the treatment, the patient was not able to move his/her head at all which permitted an accurate targeting of the treatment. The problem is that a frame-based system cannot be used for fractionated treatment in which repeated smaller does are given to the patient over some predetermined period of time, such as a couple of weeks or a month. A fractionated treatment plan is often desirable since it permits larger overall doses of treatment, such as radiation, to be applied to the target region while still permitting the healthy tissue to heal. Clearly, it is extremely difficult to leave the frame secured to the patient's head for that period of time. In addition, it is impossible to remove the frame and later reposition the frame in the exact same location for the next treatment. Thus, the frame based stereotaxy provides the desired accuracy, but cannot be used with various desirable treatment schedules.
Thus, in accordance with the invention, a system for directing a treatment beam towards a patient is provided. The system may comprise a treatment bed that supports the patient during the treatment and one or more diagnostic beam generators for generating diagnostic beams directed towards the patient during the treatment. The diagnostic beam generators may be located at different predetermined positions so that the beam from each diagnostic beam generator is at a predetermined non-zero angle with respect to the beams of the other diagnostic beam generators. The system may further comprise a single image recording device located adjacent to the treatment bed for receiving the diagnostic beams from the two or more diagnostic beam generators so that the image recording device captures the images from all of the diagnostic beams.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4132896Apr 8, 1977Jan 2, 1979U.S. Philips CorporationMethod of forming layered images of objects from superposition images of different image planesUS4237901Aug 30, 1978Dec 9, 1980Picker CorporationLow and constant pressure transducer probe for ultrasonic diagnostic systemUS4249106Nov 7, 1979Feb 3, 1981Hitachi, Ltd.Crystalline silicon substrate, amorphous silicon film containing hydrogenUS4583538May 4, 1984Apr 22, 1986Onik Gary MMethod and apparatus for stereotaxic placement of probes in the body utilizing CT scanner localizationUS5067981Sep 27, 1989Nov 26, 1991Pelt & Hooykaas B.V.Method for rendering toxic waste harmlessUS5207223Oct 19, 1990May 4, 1993Accuray, Inc.Apparatus for and method of performing stereotaxic surgeryUS5222499Mar 26, 1992Jun 29, 1993Allen George SMethod and apparatus for imaging the anatomyUS5278886Jan 5, 1993Jan 11, 1994Hitachi Medical CorporationRadiosurgery effecting position correction of collimatorUS5394875Oct 21, 1993Mar 7, 1995Lewis; Judith T.Automatic ultrasonic localization of targets implanted in a portion of the anatomyUS5397329Feb 26, 1993Mar 14, 1995Allen; George S.Fiducial implant and system of such implantsUS5411026Oct 8, 1993May 2, 1995Nomos CorporationFor use in a radiation therapy planUS5427097Dec 10, 1992Jun 27, 1995Accuray, Inc.Apparatus for and method of carrying out stereotaxic radiosurgery and radiotherapyUS5446548Oct 8, 1993Aug 29, 1995Siemens Medical Systems, Inc.Patient positioning and monitoring systemUS5447154Jul 30, 1993Sep 5, 1995Universite Joseph FourierMethod for determining the position of an organUS5537452May 10, 1994Jul 16, 1996Shepherd; Joseph S.Radiation therapy and radiation surgery treatment system and methods of use of sameUS5588430Feb 14, 1995Dec 31, 1996University Of Florida Research Foundation, Inc.Medical methodUS5622187Sep 30, 1994Apr 22, 1997Nomos CorporationMethod and apparatus for patient positioning for radiation therapyUS5628315Sep 11, 1995May 13, 1997Brainlab Med. Computersysteme GmbhDevice for detecting the position of radiation target pointsUS5727554Sep 19, 1996Mar 17, 1998University Of Pittsburgh Of The Commonwealth System Of Higher EducationApparatus responsive to movement of a patient during treatment/diagnosisUS5748700Dec 18, 1995May 5, 1998Shepherd; Joseph S.Radiation therapy and radiation surgery treatment system and methods of use of sameUS5769861Sep 12, 1996Jun 23, 1998Brainlab Med. Computersysteme GmbhMethod and devices for localizing an instrumentUS5784431Oct 29, 1996Jul 21, 1998University Of Pittsburgh Of The Commonwealth System Of Higher EducationFor matching portal images to control radiotherapy/diagnosis equipmentUS5797849Mar 7, 1997Aug 25, 1998Sonometrics CorporationMethod for carrying out a medical procedure using a three-dimensional tracking and imaging systemUS5943719Oct 29, 1997Aug 31, 1999Picker Medical Systems, Ltd.Method and device for precise invasive proceduresUS5967981Sep 26, 1997Oct 19, 1999Siemens Corporate Research, Inc.Time series prediction for event triggeringUS5971997Feb 20, 1997Oct 26, 1999Radionics, Inc.Intraoperative recalibration apparatus for stereotactic navigatorsUS6006126Jun 7, 1995Dec 21, 1999Cosman; Eric R.System and method for stereotactic registration of image scan dataUS6019724Feb 8, 1996Feb 1, 2000Gronningsaeter; AageMethod for ultrasound guidance during clinical proceduresUS6031888Nov 26, 1997Feb 29, 2000Picker International, Inc.Fluoro-assist feature for a diagnostic imaging deviceUS6076005Aug 6, 1998Jun 13, 2000St. Jude Children's Research HospitalRespiration responsive gating means and apparatus and methods using the sameUS6120453Nov 12, 1998Sep 19, 2000Sharp; William A.Three-dimensional ultrasound system based on the coordination of multiple ultrasonic transducersUS6144875Mar 16, 1999Nov 7, 2000Accuray IncorporatedApparatus and method for compensating for respiratory and patient motion during treatmentUS6149592Nov 26, 1997Nov 21, 2000Picker International, Inc.Integrated fluoroscopic projection image data, volumetric image data, and surgical device position dataUS6246898May 8, 1998Jun 12, 2001Sonometrics CorporationMethod for carrying out a medical procedure using a three-dimensional tracking and imaging systemUS6256372Mar 16, 1999Jul 3, 2001General Electric CompanyApparatus and methods for stereo radiographyUS6275721Jun 10, 1999Aug 14, 2001General ElectriccompanyInteractive MRI scan control using an in-bore scan control deviceUS6285902Feb 10, 1999Sep 4, 2001Surgical Insights, Inc.Computer assisted targeting device for use in orthopaedic surgeryUS6301495Apr 27, 1999Oct 9, 2001International Business Machines CorporationSystem and method for intra-operative, image-based, interactive verification of a pre-operative surgical planUS6307914Dec 1, 1999Oct 23, 2001Mitsubishi Denki Kabushiki KaishaMoving body pursuit irradiating device and positioning method using this deviceUS6314312Mar 29, 2000Nov 6, 2001Siemens AktiengesellschaftMethod and system for determining movement of an organ or therapy region of a patientUS6325758 *Oct 27, 1998Dec 4, 2001Nomos CorporationMethod and apparatus for target position verificationUS6380958Sep 10, 1999Apr 30, 2002Siemens AktiengesellschaftMedical-technical systemUS6405072Dec 1, 1997Jun 11, 2002Sherwood Services AgApparatus and method for determining a location of an anatomical target with reference to a medical apparatusUS6470207Mar 23, 1999Oct 22, 2002Surgical Navigation Technologies, Inc.Navigational guidance via computer-assisted fluoroscopic imagingUS6473634Nov 22, 2000Oct 29, 2002Koninklijke Philips Electronics N.V.Medical imaging at two temporal resolutions for tumor treatment planningUS6501981Sep 8, 2000Dec 31, 2002Accuray, Inc.Apparatus and method for compensating for respiratory and patient motions during treatmentUS6681129Sep 28, 2001Jan 20, 2004Olympus Optical Co., Ltd.Surgical operation navigation apparatus and methodUS6778850Sep 15, 2000Aug 17, 2004Accuray, Inc.Frameless radiosurgery treatment system and methodUS7318805Oct 18, 2002Jan 15, 2008Accuray IncorporatedApparatus and method for compensating for respiratory and patient motion during treatmentUS20020032453Aug 29, 2001Mar 14, 2002Cosman Eric R.Repositioner for head, neck, and bodyUS20020065461Jan 10, 2002May 30, 2002Cosman Eric R.Surgical positioning systemUS20020154728Feb 11, 2002Oct 24, 2002Eiichi MoritaRadiographic apparatusEP1004272A1Nov 4, 1999May 31, 2000Picker International, Inc.Tomographic imaging using penetrating radiationJP2000201922A Title not availableJP2000217810A Title not availableJPH1119082A Title not availableJPH05188199A Title not availableJPH06181918A Title not availableJPH06502330A Title not availableJPH08112272A Title not availableJPH10201863A Title not availableJPS62206798A Title not availableWO1992006644A1Oct 16, 1991Apr 30, 1992Accuray IncApparatus for and method of stereotoxic surgeryWO1997040766A1Apr 14, 1997Nov 6, 1997Univ FloridaMarker system and related stereotactic procedureWO2000007669A1Aug 6, 1999Feb 17, 2000Fitchard Edward EDelivery modification system for radiation therapy* Cited by examinerNon-Patent CitationsReference1Coste-Mani�re, �., "Robotic whole body stereotactic radiosurgery: clinical advantages of the CyberKnife� integrated system", The International Journal of Medical Robotics +Computer Assisted Surgery, 2005, www.roboticpublications.com, pp. 28-39.2English Abstract, J P8112272 published May 7, 1996, 1 page.3Examination Report for European Patent Application No. 01 970 945.0, dated Feb. 23, 2010, 6 pages.4Examination Report for European Patent Application No. 01 970 945.0, dated Jan. 16, 2007, 7 pages.5Examination Report for Japanese Patent Application 2002-526277, Apr. 19, 2007, 4 pages.6Examination Report for Japanese Patent Application 2002-526277, May 18, 2006, 4 pages.7Examination Report for Japanese Patent Application 2002-526277, Sep. 22, 2006, 3 pages.8Examination Report for Japanese Patent Application No. 2007-212216, 2 pages.9Examination Report for Japanese Patent Application No. 2007-212216, mailed Mar. 2, 2010, 1 page.10Minohara, S. et al., "Respiratory Gated Irradiation System for Heavy-Ion Radiotherapy", International Journal of Radiation: Oncology Biology Physics, Pergamon Press, US, vol. 47, No. 4, Jul. 1, 2000, ISSN: 0360-3016.11Supplementary European Search Report for European Patent Application No. 01 970 945.0 dated Apr. 5, 2006, 5 pages.12Supplementary European Search Report for European Patent Application No. 01 970 945.0, Oct. 16, 2006, 5 pages.13Supplementary Partial European search report, Application No. EP01970945, mailed Jun. 28, 2006.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS20090281658 *Apr 10, 2009Nov 12, 2009Huettenberger StefanMedical facility and method of docking a positioning device with a shuttle* Cited by examinerClassifications U.S. Classification600/427International ClassificationG01B11/00, A61B6/12, A61N5/06, A61B6/00, G01B15/00, A61B6/03, A61B17/34, A61B5/06, A61B18/00, A61N5/01, A61B17/00, A61B10/02, A61B5/055, A61B5/00, A61B8/00, G01R33/48, A61N5/10, A61N7/02, A61B18/20, A61B19/00, G01B21/00, A61B10/00Cooperative ClassificationA61B2019/5255, A61B19/20, A61N5/103, A61B19/54, A61B19/5244, A61N5/1049, A61B2019/207, A61B6/527, A61B6/12, A61N7/02, A61N5/1064, A61B10/0233, A61B2019/5272, A61N2005/1061, A61N5/1067, A61B2019/5238, A61B2017/00699, A61B2017/00694, A61B18/20European ClassificationA61N5/10E1, A61B6/12, A61B19/20, A61B19/52H12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google