Source: https://patents.google.com/patent/US6488913B2/en
Timestamp: 2019-07-19 15:05:17
Document Index: 84419570

Matched Legal Cases: ['§119', 'application No. 60', 'art 1', 'art 2', 'art 1', 'art 2', 'art 1', 'art 2', 'art 1', 'art 2', 'art 1', 'art 2', 'art 1', 'art 2', 'art 1', 'art 2']

US6488913B2 - Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals - Google Patents
Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals Download PDF
US6488913B2
US6488913B2 US09/931,275 US93127501A US6488913B2 US 6488913 B2 US6488913 B2 US 6488913B2 US 93127501 A US93127501 A US 93127501A US 6488913 B2 US6488913 B2 US 6488913B2
US09/931,275
US20020106335A1 (en
2000-09-20 Priority to US23400700P priority Critical
2001-08-16 Application filed by Scientific Pharmaceuticals Inc filed Critical Scientific Pharmaceuticals Inc
2001-08-16 Priority to US09/931,275 priority patent/US6488913B2/en
2001-12-03 Assigned to SCIENTIFIC PHARMACEUTICALS, INC. reassignment SCIENTIFIC PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BUTLER, DAVID V., ORLOWSKI, JAN A.
2002-08-08 Publication of US20020106335A1 publication Critical patent/US20020106335A1/en
2002-12-03 Publication of US6488913B2 publication Critical patent/US6488913B2/en
Described herein is a novel high efficiency teeth bleaching system based on thesynergetic action of the combination of hydrogen peroxide (in a free form or in the form of its adduct with urea) and peroxide and/or percarbonates of metals belonging to the first or second group of the periodic table. In one embodiment, the system of the preferred embodiment comprises two components, one containing hydrogen peroxide or carbamide peroxide (hydrogen peroxide/urea adduct), and the other containing metal peroxides and/or percarbonates. Mixing of the two components results in the accelerated generation of radical oxygen, which relates to faster teeth bleaching action.
This application claims priority under 35 U.S.C. §119 of provisional application No. 60/234,007, filed Sep. 20, 2000.
This invention relates generally to teeth whiteners comprising two parts, one of which contains hydrogen peroxide (in a free form or in a form of its adduct with urea) and the other peroxides and/or percarbonates of metals belonging to the first or second group of the periodic table. More specifically, the invention relates to teeth whiteners having increased storage stability while having superior bleaching efficacy.
In view of the limitations of prior art formulations, preferred embodiments of the present invention provide compositions and processes which are fast acting, non-desiccating when placed in contact with tissues, and/or are not compromised by an unduly short shelf life.
As discussed above, prior art formulations for teeth whitening tend to have one or more shortcomings, rendering them ineffective or undesirable. Many of the difficulties arise from the inherent conflict between the requirements of shelf life stability of peroxides and the understandable demand for fast bleaching action and high efficacy of the product. Part of this conflict arises from the fact that storage stability requirements impose the necessity of maintaining low pH on commercial teeth whitening formulations, especially those based on hydrogen peroxide, which is objectionable because of the potentially damaging effect of such acidic materials on teeth and mucosa and the slow generation of radical (atomic) oxygen in the oral environment which impairs the speed and efficacy of the teeth bleaching process.
The new teeth whitening system consists of at least two parts separated from each other during storage but mixed shortly or immediately before application. In a preferred two-component embodiment, the two components, referred to herein as Part 1 and Part 2, are preferably mixed shortly or immediately before application. Although the preferred embodiments are described and exemplified herein by means of two components, it is to be understood that the preferred embodiments are intended to cover formulations comprising more than two components. As used herein “shortly before application” means 6 to 30 minutes before application, preferably 20-30 minutes before application, and “immediately before application” means within about 5 minutes of application. The whitener may still be used more than 30 minutes after mixing, but, due to peroxide decomposition, some or most of its whitening effectiveness may be absent.
* glycerin 54.5 g
* water 27.58 g
* polyethylene oxide (MW 400,000) 14.0 g
* hydrogen peroxide 4.0 g
* sodium pyrophosphate 0.1 g
* glycerin 42.4 g
* calcium peroxide 28 5 g
* water 16.8 g
* silica 6.5 g
* zinc peroxide 4.9 g
* carboxymethyl cellulose 0.9 g
The two components were mixed in a 1:1 ratio by weight. The pH of the mixture was 12 at 26.5° C. When 1 drop of FD&C Blue #1 was added, the color disappeared entirely within 8 minutes.
* glycerin 44.9 g
* calcium peroxide 30.2 g
* water 17.75 g
* silica 6.25 g
The pH of a 1:1 mixture was 10.5 at 26.5° C. The color from 1 drop of FD&C Blue #1 disappeared within 10 minutes.
* glycerin 53.8 g
* water 21.4 g
* calcium peroxide 19.0 g
* silica 5.0 g
The pH of a 1:1 mixture by weight was 10.23 at 25.9° C. The color from 1 drop of FD&C Blue #1 discolored within 20 minutes.
* glycerin 86.0 g
* carbamide peroxide 11.0 g
* partially neutralized polyacrylic acid 3.0 g
The pH of a 1:1 mixture by weight was 9.72 at 25.4° C. When 1 drop of FD&C Blue #1 was added, the discoloration time was between 15 and 20 minutes.
* glycerin 84.3 g
* carbamide peroxide 13 g
* partially neutralized polyacrylic acid 2.7 g
When the two components were mixed in a 1:1 ratio by weight, the pH was 9.75 at 25.6° C. when 1 drop of FD&C Blue #1 was added, the mixture discolored in between 15 and 20 minutes.
* glycerin 55.7 g
* calcium peroxide 12.9 g
* water 22.2 g
* silica 7.7 g
* carboxymethyl cellulose 1.1 g
* sodium percarbonate 0.3 g
The pH of a 1:1 mixture by weight was 10.8 at 27.6° C.; the discoloration time of one drop of FD&C Blue #1 was added was 15 minutes.
1. A teeth whitening composition comprising:
Part 1 comprising peroxide in free form or the form of an adduct with urea; and
Part 2 comprising peroxides and/or percarbonates of bivalent metals;
wherein Part 1 and Part 2 are mixed together shortly or immediately before application to form a blend having a pH of about 7 to about 12.
2. The teeth whitening composition of claim 1 wherein said peroxides and/or percarbonates of bivalent metals belong to the second group of the periodic table.
preparing a teeth whitening composition comprising at least two parts: a Part 1, comprising hydrogen peroxide in free form or the form of an adduct with urea and a Part 2, comprising peroxides and/or percarbonates of metals belonging to the second group of the periodic table; wherein Part 1 and Part 2 are mixed together shortly or immediately before application to form a material having a pH from about 8.5 to about 10.5; and
contacting the teeth whitening composition with the teeth for a time sufficient to increase the whiteness of the teeth.
31. The teeth whitening procedure of claim 30, wherein the teeth whitening composition is applied to the teeth by means of flexible trays or forms.
Part 1 comprising peroxide in free form or the form of an adduct at a concentration of about 2 to about 15% by weight hydrogen peroxide; and
Part 2 comprising peroxides and/or percarbonates of metals belonging to the second group of the periodic table, wherein said metal is selected from the group consisting of calcium, zinc, strontium, and magnesium at a concentration of about 2 to about 50% by weight; and
wherein Part 1 and Part 2 are mixed together shortly or immediately before application to form a blend having a pH of about 7.5 to about 12.
US09/931,275 2000-09-20 2001-08-16 Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals Active US6488913B2 (en)
US23400700P true 2000-09-20 2000-09-20
US09/931,275 US6488913B2 (en) 2000-09-20 2001-08-16 Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals
US20020106335A1 US20020106335A1 (en) 2002-08-08
US6488913B2 true US6488913B2 (en) 2002-12-03
ID=26927455
US09/931,275 Active US6488913B2 (en) 2000-09-20 2001-08-16 Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals
US (1) US6488913B2 (en)
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2001-08-16 US US09/931,275 patent/US6488913B2/en active Active
US8974772B2 (en) 2004-12-28 2015-03-10 Colgate-Palmolive Company Two phase toothpaste composition
US20020106335A1 (en) 2002-08-08
CA1202910A (en) 1986-04-08 Aqueous oral solution
Walsh 2000 Safety issues relating to the use of hydrogen peroxide in dentistry
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ORLOWSKI, JAN A.;BUTLER, DAVID V.;REEL/FRAME:012324/0703