Source: http://www.google.fr/patents/US5776485
Timestamp: 2013-06-19 22:58:54
Document Index: 238169990

Matched Legal Cases: ['application No. 07', 'application No. 07', 'application No. 08', 'application No. 08', 'application No. 07', 'application No. 07', 'application No. 08', 'application No. 08', 'application No. 07', 'application No. 07', 'application No. 08', 'application No. 07', 'application No. 07', 'application No. 08', 'application No. 07', 'application No. 07']

Brevet US5776485 - Enhanced skin penetration system for improved topical delivery of drugs - Google�BrevetsRecherche Images Maps Play YouTube Actualit�s Gmail Drive Plus » Recherche avanc�e dans les brevets | Historique Web | Connexion Recherche avanc�e dans les brevets BrevetsThe invention involves pharmaceutical compositions for topical application comprising: (a) a safe and effective amount of a pharmaceutical active; and (b) from about 0.05% to about 5% of a non-ionic polyacrylamide having a molecular weight of from about 1,000,000 to about 30,000,000....http://www.google.fr/patents/US5776485?utm_source=gb-gplus-shareBrevet US5776485 - Enhanced skin penetration system for improved topical delivery of drugs Num�ro de publicationUS5776485 AType de publicationOctroi Num�ro de demande08/469,701 Date de publication7 juil. 1998 Date de d�p�t6 juin 1995 Date de priorit�16 oct. 1991Autre r�f�rence de publicationCA2120927A1, CN1072863A, DE69224294D1, DE69224294T2, EP0608320A1, EP0608320B1, US5756118, US5756119, US5773023, US5780049, US5874095, WO1993007902A1 Num�ro de publication08469701, 469701, US 5776485 A, US 5776485A, US-A-5776485, US5776485 A, US5776485A InventeursGeorge Endel Deckner, Brian Scott Lombardo Cessionnaire d'origineRichardson-Vicks Inc.Citations de brevets (57), Citations hors brevets (32), R�f�renc� par (1), Classifications (35) Liens externes: USPTO, Cession USPTO, EspacenetEnhanced skin penetration system for improved topical delivery of drugsUS 5776485 A R�sum� The invention involves pharmaceutical compositions for topical application comprising:
______________________________________Ingredient        (% W/W)______________________________________Water, Purified   52.395Alcohol SDA 40    40.000Polyacrylamide and             4.000C.sub.13-14 Isoparaffin andLaureth-7Salicylic Acid    2.000Glycerin          1.000Aloe Vera Gel     0.500Menthol           0.100Disodium EDTA     0.005______________________________________
______________________________________Ingredient        (% W/W)______________________________________Water, Purified   55.0Ibuprofen         2.0Alcohol SDA 40    40.0Polyacrylamide and             3.0C.sub.13-14 Isoparaffin andLaureth-7______________________________________
______________________________________Ingredient        (% W/W)______________________________________Water             86.5Urea              10.0Benzyl Alcohol    0.5Polyacrylamide and             3.0C.sub.13-14 Isoparaffin andLaureth-7______________________________________
______________________________________Ingredient        (% W/W)______________________________________Water             91.5Benzyl Alcohol    0.5Polyacrylamide and             3.0C.sub.13-14 Isoparaffin andLaureth-7Dihydroxyacetyone 3.0Glycerin          2.0______________________________________
Nonionic Polyacrylamide The non-ionic polymers useful in the present invention are polyacrylamides and substituted polyacrylamides, branched or unbranched. These polymers are non-ionic water-dispersable polymers which can be formed from a variety of monomers including acrylamide and methacrylamide which are unsubstituted or substituted with one or two alkyl groups (preferably C.sub.1 -C.sub.5). Preferred acrylate amides and methacrylate amides in which the amide nitrogen is unsubstituted, or substituted with one or two C.sub.1 -C.sub.5 alkyl groups (preferably: methyl, ethyl or propyl), for example, acrylamide, methacrylamide, N-methylacrylamide, N-methylmethacrylamide, N,N-dimethylmethacrylamide, N-isopropylacrylamide, N-isopropylmethacrylamide and N,N-dimethylacrylamide. These monomers are generally disclosed in U.S. Pat. No. 4,963,348 to Bolich, Jr. et al., issued Oct. 16, 1990, incorporated by reference herein in its entirety. These copolymers may optionally be formed using conventional neutral crosslinking agents such as dialkenyl compounds. The use of such crosslinking agents for cationic polymers is disclosed in U.S. Pat. No. 4,628,078 to Glover et al. issued Dec. 9, 1986 and U.S. Pat. No. 4,599,379 to Flesher et al. issued Jul. 8, 1986 both of which are incorporated by reference herein. These non-ionic co-polymers have a molecular weight greater than about 1,000,000 preferably greater than about 1,500,000 and range up to about 30,000,000. Preferably, as a result of being synthesized by reverse phase emulsion polymerization, these non-ionic polyacrylamides are predispersed in a water-immiscible solvent such as mineral oil and the like, containing a high HLB surfactant (HLB from about 7 to about 10) which helps to facilitate water dispersibility of the polyacrylamide. Most preferred for use herein is the non-ionic polymer under the CTFA designation: polyacrylamide and isoparrafin and laureth-7, available as Sepigel from Seppic Corporation.
Full thickness excised human thigh skin is obtained from cadavers after all hair had been clipped and the skin washed. The skin samples are then bathed in 10% glycerin and stored frozen. The glycerin prevents the formation of ice crystals which could possibly damage the keratinized cells and/or the intercellular lipid matrix. After a rapid thawing, the skin is conditioned for 24 hours in Hank's Balanced Salt Solution with 1% antibacterial-antimycotic solution. Then the skin is washed with distilled water. A single skin donor is used for each experiment, and individual sections for use are selected based on integrity of the stratum corneum (visual determination). Selected areas are cut to 1cm.sup.2 using a scalpel.
Tests are conducted using glass diffusion cells placed in temperature-regulated stirring modules. Skin sections are mounted in the cells, and the receptor phase is added. The receptor phase is 50% Hank's Balance Salt Solution with 1% antibiotic-antimycotic solution. Each diffusion cell has an exposed area of 0.79cm.sup.2 and a receptor capacity of 5ml. Sufficient formulation is applied (750 ul) to the surface of the skin to ensure infinite dose conditions, and the diffusion cell is covered with plastic wrap or parafilm to prevent product evaporation. At each sampling time the receptor phase is removed for analysis of drug content. The receptor phase is removed for analysis of drug content. The receptor phase is replenished at each sampling time in order to maintain sink conditions. Preferably 3 to 6 replicates are run with sampling intervals occurring at 1, 2, 4 & 6 hours.
Citations de brevets Brevet cit� Date de d�p�t Date de publication D�posant TitreUS3624019 *15 d�c. 197030 nov. 1971Nalco Chemical Co.Process for rapidly dissolving water-soluble polymersUS3920808 *8 mai 197318 nov. 1975Regents Of The University Of MinnesotaMethod of protecting human skin from actinic radiationUS3920810 *23 avr. 197418 nov. 1975Burton, Parsons And Company, Inc.Polyacrylamide containing ophthalmic solutionsUS4039501 *30 mai 19752 ao�t 1977National Patent Development CorporationPlasticized hydrophilic polymersUS4307717 *28 juil. 198029 d�c. 1981Lectec CorporationSterile improved bandage containing a medicamentUS4318907 *4 avr. 19789 mars 1982Westwood Pharmaceuticals, Inc.Method for treating acne vulgaris and compositions useful for that purposeUS4355028 *30 avr. 198119 oct. 1982Westwood Pharmaceuticals, Inc.Composition for treating acne vulgarisUS4478853 *17 mai 198223 oct. 1984S. C. Johnson & Son, Inc.Skin conditioning compositionUS4540568 *27 juin 198410 sept. 1985Trager; Seymour F.Injectionable viscoelastic ophthalmic gelUS4599379 *16 janv. 19858 juil. 1986Allied Colloids Ltd.Process for the production of polymers and aqueous solutions thereofUS4628078 *12 juin 19859 d�c. 1986Allied Colloids Ltd.Acrylamide-dialkylaminoacrylate-dialkylaminomethacrylate cationic polyelectrolytes and their productionUS4650827 *2 nov. 198317 mars 1987Allied CorporationStable water-in-oil emulsionsUS4673704 *27 juin 198516 juin 1987Allied Colloids LimitedAqueous polymer dispersionsUS4675009 *31 mars 198623 juin 1987Lec Tec CorporationDrug dispensing device for transdermal delivery of medicamentsUS4704436 *2 mai 19863 nov. 1987Barabas; Eugene S.Water soluble complex of a poly(vinylpyrrolidone) copolymer and α-methyl-(2-methylpropyl)benzene acetic acidUS4731242 *21 mars 198615 mars 1988Palinczar; VictorWaterproof sunscreen compositionsUS4806345 *21 nov. 198521 f�vr. 1989Nalco Chemical CompanyCross-linked cationic polymers for use in personal care productsUS4835206 *30 sept. 198730 mai 1989Allied Colloids, Ltd.Water soluble polymeric compositionsUS4837019 *11 ao�t 19866 juin 1989Charles Of The Ritz Group Ltd.Skin treatment composition and method for treating burned skinUS4849484 *18 sept. 198718 juil. 1989Allied Colloids, Ltd.Polymeric particles, their manufacture and usesUS4885161 *6 janv. 19895 d�c. 1989Medi-Tech International CorporationWound dressings in gelled paste formUS4915940 *15 nov. 198810 avr. 1990Shionogi & Co., Ltd.Film-formation-type antifungal preparationUS4927408 *3 oct. 198822 mai 1990Alza CorporationElectrotransport transdermal systemUS4929577 *11 mars 198729 mai 1990Medi-Tech International CorporationTransparent wound dressings in sheet formUS4938951 *9 d�c. 19853 juil. 1990Union Carbide Chemicals And Plastics Company Inc.Potentiation of topical compositions wherein a uniform microdispersion of active agent is formedUS4948586 *18 ao�t 198814 ao�t 1990Lim Technology Laboratories, Inc.Microencapsulated insecticidal pathogensUS4954487 *15 f�vr. 19894 sept. 1990The Procter & Gamble CompanyPenetrating topical pharmaceutical compositionsUS5009969 *26 mai 198923 avr. 1991Hi-Tek Polymers, Inc.Dual action sunscreen compositionUS5017367 *6 janv. 198721 mai 1991Stojkoski; Radmila G.Skin treatment preparationUS5043359 *5 mars 199027 ao�t 1991Dow Corning CorporationSkin conditioning compositions containing glyceroxyfunctional silanes and siloxanesUS5057560 *21 mai 199015 oct. 1991Ciba-Geigy CorporationThermotropic copolymer hydrogels from N,N-dimethylacrylamide and methoxy-ethyl (meth) acrylateUS5100658 *16 juil. 199031 mars 1992The Procter & Gamble CompanyVehicle systems for use in cosmetic compositionsUS5100660 *20 avr. 199031 mars 1992Allied Colloids LimitedThickened acidic aqueous compositions using cross-linked dialkylaminoacrylic microparticlesUS5110853 *27 ao�t 19905 mai 1992Exxon Chemical Patents Inc.Freeze-thaw stable polyacrylamide emulsionsUS5147923 *3 f�vr. 199215 sept. 1992Ciba-Geigy CorporationThermotropic biphilic hydrogels and hydroplasticsUS5169624 *23 f�vr. 19918 d�c. 1992Chesebrough-Pond'S Usa Co., Division Of Conopco, Inc.Waterproof sunblock compositionsUS5200448 *27 mars 19926 avr. 1993Exxon Chemical Patents Inc.Freeze-thaw stable polyacrylamide emulsionsUS5221530 *24 juin 199122 juin 1993Helene Curtis, Inc.Mild conditioning shampoo with a high foam level containing an anionic surfactant-cationic acrylate/acrylamide copolymer conditioning agentUS5232688 *17 juin 19923 ao�t 1993Chesebrough-Pond'S Usa Co., Division Of Conopco, Inc.Self-tanner cosmetic compositionsUS5302378 *17 juin 199212 avr. 1994Chesebrough-Pond'S Usa Co.Self-tanner cosmetic compositionsUS5422118 *21 sept. 19926 juin 1995Pure Pac, Inc.Transdermal administration of amines with minimal irritation and high transdermal flux rateUS5458872 *29 janv. 199117 oct. 1995Durand; MurielMethod for the protection of dihydroxyacetone, a dihydroxyacetone protected by this method, and a cosmetic product containing such a protected dihydroxyacetoneUS5614178 *27 juin 199425 mars 1997The Procter & Gamble CompanyCompositions for topical delivery of drugs comprising a mixture of high and low HLB surfactants and alkoxylated etherUS5618522 *20 janv. 19958 avr. 1997The Procter & Gamble CompanyEmulsion compositionsUSRE28474 *8 nov. 197320 d�c. 1983Nalco Chemical CoProcess for rapidly dissolving water-soluble polymersCA1300513A * Titre non disponibleEP0067658A2 *9 juin 198222 d�c. 1982Alcon Laboratories, Inc.Carboxyvinyl polymer urea gel compositionsEP0228868A2 *17 d�c. 198615 juil. 1987Allied Colloids LimitedCopolymers and their useEP0312208A1 *16 sept. 198819 avr. 1989Ethicon Inc.Gel formulations containing growth factorsEP0424282A1 *9 oct. 199024 avr. 1991ErpharSun tanning cosmetic preparationFR2651126A1 * Titre non disponibleGB2236760A * Titre non disponibleJP2071745A * Titre non disponibleJP57091913A * Titre non disponibleWO1992017159A2 *13 mars 199215 oct. 1992Richardson-Vicks Inc.Stabilized emulsion compositions for imparting an artificial tan to human skinWO1993007856A1 *13 oct. 199229 avr. 1993Richardson-Vicks, Inc.LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVESWO1993007903A1 *13 oct. 199229 avr. 1993Richardson-Vicks, Inc.Enhanced skin penetration system for improved topical delivery of drugs* Cit� par l'examinateurCitations hors brevetsR�f�rence1 *Bohm et al Derwent of US 4948586 (Aug. 14, 1990).2 *Bolich et al Derwent of US 5100658 (Mar. 31, 1992) and (EP 412705 (Feb. 13, 1991).3 *Cotte et al C.A. 115:239330 of EP424282 Apr. 24, 1991.4 *Cotter et al C.A. 115:990004 of FR 2651 126 (Mar. 1991).5 *Durand Derwent of WO/Pct 91 12222 (Aug. 22, 1991) and U.S. 5458872 (Oct. 17, 1995).6 *Fusaro C.A. 84:49847 of U.S. 3920808 (Nov. 1975).7 *Futterer Cosmet. Perfum. 88(8): 31 33 Theory and Practice of Artificial Tanning , 1973.8Futterer Cosmet. Perfum. 88(8): 31-33 "Theory and Practice of Artificial Tanning", 1973.9 *Futtterer C.A. 79: 139608 of Cosmet. Perfum 88(8): 31 33 (1973).10Futtterer C.A. 79: 139608 of Cosmet. Perfum 88(8): 31-33 (1973).11 *Isacoff C.A. 78:115119 of Cosmet. Perfum 88(2): 35 37(1973).12Isacoff C.A. 78:115119 of Cosmet. Perfum 88(2): 35-37(1973).13 *Isacoff Cosmet. Perfum. 88(2):35 37 Polyaerylamides in Cosmetics , 1973.14Isacoff Cosmet. Perfum. 88(2):35-37 "Polyaerylamides in Cosmetics", 1973.15 *Leung et al Derwent of U.S. 4938951 (Jul. 3, 1990).16 *Mueller Derwent of U.S. 5057560 (Oct. 15, 1991).17 *Mueller Derwent of U.S. 5147923 (Sep. 15, 1992).18 *Quack et al C.A. 91:216665 of GEROFFDE 2806098 (Feb. 1978).19 *Sales Literature, Salcare SC91: The Cosmetic Formulator s Choice for Anionic Skin Care Products, undated.20Sales Literature, Salcare SC91: The Cosmetic Formulator's Choice for Anionic Skin Care Products, undated.21 *Sales Literature, Salcare SC92 for Cosmetic/Personal Care Applications, undated.22 *Sales Literature, Sepigel 305, Thickening Agent for Aqueous Gels and Emulsions, undated.23Seppic Sepigel Paraffin Agent for Gels and Sun Gel Lavreth-7 (Mar. 1991).24 *Seppic Sepigel 305 Thickening Agent for Aqueous Gels and Emulsions , Mar. 1991.25 *Seppic Sepigel 305 Thickening Aqueous Emulsions Poly Acrylamide, Iso Paraffin Agent for Gels and Sun Gel Lavreth 7 (Mar. 1991).26Seppic Sepigel Mar. 1991.27 *U.S. application No. 07/931,553, Deckner et al., filed Aug. 18, 1992, withic is a continuation of U.S. application No. 07/778,423, Deckner et al., filed Oct. 16, 1991.28 *U.S. application No. 08/079,977, Bloom et al., filed Jun. 25, 1993, which is a continuation in part of U.S. application No. 08/033,211, Bloom et al., filed Mar. 18, 1993, which is a continuation in part of U.S. application No. 07/950,527, Bloom et al., filed Sep. 25, 1992, which is a continuation in part of U.S. application No. 07/920,937, Bloom et al., filed Jul. 28, 1992.29U.S. application No. 08/079,977, Bloom et al., filed Jun. 25, 1993, which is a continuation-in-part of U.S. application No. 08/033,211, Bloom et al., filed Mar. 18, 1993, which is a continuation-in-part of U.S. application No. 07/950,527, Bloom et al., filed Sep. 25, 1992, which is a continuation in part of U.S. application No. 07/920,937, Bloom et al., filed Jul. 28, 1992.30 *U.S.application No. 08/059,001, Deckner et al., filed May 6, 1993, which is a continuation of U.S. application No. 07/948,391, Deckner et al., filed Sep. 25, 1992, which is a continuation in part of U.S. application No. 07/778,423, Deckner et al., filed Oct. 16, 1991.31U.S.application No. 08/059,001, Deckner et al., filed May 6, 1993, which is a continuation of U.S. application No. 07/948,391, Deckner et al., filed Sep. 25, 1992, which is a continuation-in-part of U.S. application No. 07/778,423, Deckner et al., filed Oct. 16, 1991.32 *Woodin Derwent WO/PCT 92 1715.9 (Oct. 15, 1992) of U.S. 91/679892 (Apr. 3, 1991).* Cit� par l'examinateur R�f�renc� par Brevet citant Date de d�p�t Date de publication D�posant TitreEP2075014A227 mai 20031 juil. 2009Angiotech International AgCompositions and methods for coating medical implantsClassifications Classification aux �tats-Unis424/449, 514/944, 514/772.6, 514/946, 514/789, 514/938, 514/772.3 Classification internationaleA61K9/113, A61K31/78, A61K9/107, A61K8/81, A61K8/35, A61Q19/00, A61K45/08, A61Q19/04, A61K8/368, A61K8/36, A61K47/32, A61K9/00 Classification coop�rativeA61K8/8158, A61K8/35, A61K9/0014, A61Q19/00, A61Q19/04, A61K47/32, A61K8/368, A61K8/36 Classification europ�enneA61K47/32, A61K9/00M3, A61Q19/00, A61K8/35, A61K8/36, A61K8/81K6, A61K8/368, A61Q19/04Faire pivoterImage d'origineAccueil Google - Plan du site - T�l�chargements par lot sur l'USPTO - R�gles de confidentialit� - Conditions d'utilisation - � propos de Google�Brevets - Envoyer des commentairesDonn�es fournies par IFI CLAIMS Patent Services©2012 Google