Source: http://www.google.com.tw/patents/US6934836
Timestamp: 2013-05-25 19:07:33
Document Index: 513393494

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'art 2']

�M�Q US6934836 - Fluid separation conduit cartridge with encryption capability - Google �M�Q�j�M �Ϥ� �a�� Play YouTube �s�D Gmail ���ݵw�� ��h »�i���M�Q�j�M | �������� | �n�J�i���M�Q�j�M�M�QA fluid separation conduit cartridge that is operative to encrypt, decrypt, transmit and receive information is disclosed. The conduit cartridge encrypts information sent to an analytical system or an operating facility in communication with the conduit cartridge and can decrypt encrypted information...http://www.google.com.tw/patents/US6934836?utm_source=gb-gplus-share�M�Q US6934836 - Fluid separation conduit cartridge with encryption capability���}��US6934836 B2�X���������v�ӽЮѽs��10/034,757�o�G���2005�~8��23���ӽФ��2001�~12��27�� �u���v���2000�~10��6����L���}�M�Q��US20020199094�o��HDavid StrandPeter MyersTim Myers��M�Q�v�HProtasis Corporation ���M�Q������713/150713/194713/193��ڱM�Q������B01L3/00B01J19/00G01N30/88G01N30/60H04L9/32B81B1/00G01N30/24 �X�@����G01N30/6026B01L3/545B01L2200/027H04L2209/80G01N30/6095B01L2300/024B01L2300/023H04L2209/56G01N30/24B01L3/502715B01J19/0093G01N30/6091G01N30/6034H04L9/3247G01N30/88H04L2209/30B01L2200/10G01N2030/8881 �ڬw������B01L3/5027BB01L3/545B01J19/00RG01N30/88G01N30/60MH04L9/32S�ѦҤ��m�M�Q�ޥ� (4)�D�M�Q�ޥ� (5)�Q�H�U�M�Q�ޥ� (4)�~���s�����M�Q�ӼЧ� ���M�Q�ӼЧ��M�Q����T�� �ڬw�M�Q��Fluid separation conduit cartridge with encryption capabilityUS 6934836 B2�K�n A fluid separation conduit cartridge that is operative to encrypt, decrypt, transmit and receive information is disclosed. The conduit cartridge encrypts information sent to an analytical system or an operating facility in communication with the conduit cartridge and can decrypt encrypted information received from an analytical system or an operating facility in communication with the conduit cartridge.
This is a continuation of International Application No. PCT/US10/31295 filed on Oct. 05, 2001 and titled ��Fluid Separation Conduit Cartridge with Encryption Capability. ��
CROSS-REFERENCED APPLICATIONS This application claims priority to commonly assigned U.S. Patent Application No. 60/239,010 titled ��Microfluidic Substrate Assembly and a Method for Making Same�� and filed on Oct. 06, 2000, commonly assigned U.S. Patent Application No. 60/239,063 titled ��Liquid Separation Column Smart Cartridge�� and filed on Oct. 06, 2000, commonly assigned U.S. Patent Application No. 60/238,805 titled ��Liquid Separation Column Smart Cartridge with Encryption Capability�� and filed on Oct. 06, 2000, and commonly assigned U.S. Patent Application No. 60/238,390 titled ��Microfluidic Substrate Assembly and a Method for Making Same�� and filed on Oct. 06, 2000, the entire disclosure of each of which is hereby incorporated herein by reference for all purposes.
BACKGROUND Molecules can be separated effectively by employing liquid chromatography (��LC��). A typical liquid chromatography system consists of a column and solvent that traverses the entire column. High pressures are usually required to pump solvent through the column leading to the development of high pressure or high performance liquid chromatography (HPLC). High performance liquid chromatography systems typically consist of high pressure pumps, at least one solvent reservoir, a column capable of withstanding relatively high pressures, and a detector. Columns used in HPLC typically consist of packing material. In most instances this packing material includes silica-based particles typically with functional groups (defining a column's chemistry) attached to these silica-based particles. The packing of the column is a critical event in the construction of a specific column, for the integrity of the packed bed impacts the overall resolution capability of the column. As the bed becomes disrupted through any series of events, for example, sharp periodic fluctuations in column pressure, resolution will decrease. Maintaining the integrity of the packing bed is essential if the original efficiency capability of a particular column is to be preserved. Through continued usage, the column's packed bed and the bonded phase deteriorate, and the= resolving power of the column is then lost. Detection and recordation of this loss of resolving power is very important.
Capillary liquid chromatography is a micro-version of traditional liquid chromatography. As is true for traditional liquid chromatography, the column used in capillary liquid chromatography is of critical import. These columns typically have low solvent consumption and require low volumes of sample for analysis. These conditions translate into a higher degree of unit mass detectability. Capillary liquid chromatography systems typically comprise a micro-pumping unit, a capillary column, a detector, and a data processing system. Capillary liquid chromatography columns are typically produced using such materials as fused silica, stainless steel, or polymeric compositions. The lumen of the capillary is packed with packing material containing separation material, such as bonded silica particles. Typically, the internal diameter of the capillary column is between 50 and 500 �gm.
In accordance with another aspect, the fluid separation conduit cartridge comprises a housing unit, a fluid separation conduit defined within the housing unit and a ferrule subassembly, as described above, at the housing inlet orifice and/or outlet orifice. The fluid separation conduit may be defined or formed, for example, by a lumen or tube, e.g., a flexible tube. Typically such tube is connected at one end to the inlet orifice and at the other end at the outlet orifice. The fluid separation conduit, or a portion thereof, may be defined by a channel formed from assembling individual layers into a multi-layer laminated substrate, such as the fluid handling substrates described in commonly assigned U.S. Patent Application No. 60/239,010 titled ��Microfluidic Substrate Assembly and a Method of Making Same�� and filed on Oct. 06, 2000, the entire disclosure of which is hereby incorporated by reference for all purposes. In certain embodiments, the fluid separation conduit comprises one or more flexible tubes that terminate at opposite ends of a channel formed by assembling the layers of a multi-layer laminated substrate. That is, in certain embodiments the fluid separation conduit comprises at least one flexible tube in fluid communication with at least one channel, where the fluid separation conduit is defined by the at least one tube and the channel. The fluid separation conduit has at least first and second openings for entry and exit of fluid, respectively. The cross-sectional diameter of the fluid separation conduit may vary depending on the desired flow rate, desired operation pressure, conduit shape, and the like. For example, for a cylindrical fluid separation conduit comprising a flexible tube, e g. a coiled capillary tube, the inner diameter of the conduit can range from a few microns to about 4-5 mm. An exemplary inner diameter for a tubular conduit suitable to provide 1 uL/min flow rate under typical fluid pressures is about 320 um. Other exemplary inner diameters include about 50 um, about 75 um, about 800 um, about 1 mm, about 2 mm, and about 3.9 mm. An inner diameter of about 3.9 mm or 4.6 mm is suitable, for example, for certain conventional chromatography applications. Suitable wall thicknesesss, e.g. the difference between an inner diameter and an outer diameter include, 1/16 of an inch, ¼ of an inch, and ⅜ of an inch. In preferred embodiments, an inlet orifice in the housing unit is in fluid communication with a first end of the fluid separation conduit within the housing, and an outlet orifice in the housing unit is in fluid communication with a second end of the fluid separation conduit. The fluid separation conduit provides a fluid flow path within the housing from the inlet orifice to the outlet orifice. A first connector, e.g. a first ferrule-sub assembly, and a second connector, e.g. a second ferrule sub-assembly, can be fitted to the first end and the second end of the fluid separation conduit, respectively. More specifically, in embodiments comprising ferrule sub-assemblies each of the ferrule sub-assemblies comprises a ferrule or end cap seated over the end of the fluid separation conduit. The ferrule sub-assembly preferably comprises a compression ring securing the attachment to the fluid separation conduit and/or creating a fluid-tight seal between the end of the conduit and other channels or devices in fluid communication with the fluid separation conduit. The ferrule sub-assemblies, further described below, each preferably provides a seating and sealing surface for its respective fluid flow port. In preferred embodiments, the ferrule sub-assembly comprises a frit body providing the seating and sealing surface. Preferably each of the ferrule sub-assemblies is secured to the housing unit in a fixed position, optionally being removably fixed, at its respective port. In this manner, the fluid separation conduit can be conveniently anchored to the housing unit, e.g., to a component of the housing unit which is assembled with one or more other housing components after the fluid separation conduit is attached, to construct the housing unit of the conduit cartridge. In certain embodiments, a surface of the ferrule sub-assembly at the inlet end of the fluid separation conduit is a substantially flat surface having a fluid opening for the inlet port and facing substantially outwardly from the housing unit to seat and seal conveniently against a corresponding surface of a fluid feed line or other fluid source feeding fluid to the fluid separation conduit cartridge for testing, analysis, etc. Similarly, a surface of the ferrule sub-assembly attached to the outlet end of the fluid separation conduit provides a substantially flat surface having a fluid opening for the outlet port and facing substantially outwardly from the housing to seat and seal conveniently against a corresponding surface of a fluid return or waste line or other fluid receiving device for accepting fluid from the fluid separation conduit cartridge after it has been tested, analyzed or subjected to other operation(s) by the fluid separation conduit within the housing. It should be recognized that the designation of a port of the housing unit as being an inlet port or an outlet port may in certain instances be arbitrary and merely a matter of convenience or choice, such as where the conduit cartridge is usable in either direction, preferably then being side-to-side symmetrical so that it can be properly installed in either orientation. In other embodiments, an outwardly extending connector is provided on a fluid separation conduit cartridge to enable insertion of the conduit cartridge fluid ports into wells or receiving sockets of a manifold or mounting device or the like, for fluid connection and sealing. As discussed above, the housing unit may comprise innumerable other devices positioned within or attached to the housing unit and or components thereof, e.g. the fluid separation conduit, the memory unit, the ferrule subassemblies, etc.
In accordance with an additional aspect, the fluid separation conduit cartridge disclosed here can be used to separate one or more species in a fluid. As used here, separate, separation, or fluid separation refers to resolving two or more species in the fluid. Preferably, baseline separation, e.g. baseline resolution, is achieved using the conduit cartridge disclosed here to provide for accurate quantitative measurements of the species in the fluid. The fluid separation conduit of the conduit cartridge disclosed here may take numerous forms, e.g. cylindrical, serpentine, coiled, and the like, and preferably contains one or more types of fluid separation media (also referred to below as a stationary phase(s)) for separating species in a fluid. As used here stationary phase refers to the material(s) coated, adsorbed, absorbed, or attached to the inner surfaces of the fluid separation conduit, e.g. the surfaces of the fluid separation conduit that are contacted by fluid from a fluid reservoir, for example. The stationary phase is operative to adsorb and to allow for desorption of species in the fluid, e.g. allows for reversible adsorption of species in the fluid. Based on the differential solubilities of the species in the fluid and in the stationary phase, the stationary phase acts to separate the species in the fluid. As used here differential solubilities refers to the solubility of a species in the stationary phase and in a fluid passing over or through the stationary phase, e.g. the mobile or fluid phase. For example, if a given species is more soluble in the stationary phase than in the fluid phase, then the given species remains adsorbed to the fluid separation conduit and does not elute. However, when the species becomes more soluble in the fluid phase than in the stationary phase, e.g. by altering the composition of the fluid phase using a solvent gradient, for example, the species is desorbed from the stationary phase and elutes from the fluid separation conduit, e.g. flows out of the cartridge in the fluid phase. Because different species have different solubilities in the different phases, e.g. partition differently between the stationary and fluid phases, depending on the selected nature of the stationary phase and the fluids, separation of the species in a fluid can be achieved. The nature of the stationary phases may vary depending on the intended use of the fluid separation conduit cartridge. For example, C18 phases may be used for separation of generally non-polar species in a fluid while strong anion exchangers (SAX) might be used for separation of charged species in a fluid. One skilled in the art given the benefit of this disclosure will be able to select suitable stationary phases for an intended use. Preferably the stationary phase is selected from materials having nonpolar functional groups, e.g. C18 and the like, materials with negatively charged functional groups, e.g. R1�XSO3 − groups, R1�XCOO− groups and the like, and materials with positively charged functional groups, e.g. R2�XNH3 + groups and the like, where R1 and R2 may be any group linked to the SO3 −/COO− and NH3 + moieties respectively. Depending on the nature of the stationary phases, suitable fluid phases may be chosen such that the species in a fluid will elute at different times, e.g. the species will have different retention times. One skilled in the art given the benefit of this disclosure will be able to select suitable fluid phases for separating one or more species in a fluid. In preferred embodiments, a solvent gradient is used to separate the species in a fluid. As used here solvent gradient refers to changing the composition of the fluid phase with increasing time. Suitable solvent gradient methods will be apparent to those skilled in the art given the benefit of this disclosure and exemplary solvent gradient methods are discussed below.
In accordance with an additional method aspect, a method for making a fluid separation conduit cartridge comprising a fluid separation conduit that is potted is disclosed. An assembled fluid separation conduit cartridge is provided, comprising at least a housing unit, and one or more potting compounds are disposed within, or optionally on or around, the conduit cartridge. The potting compounds may be disposed using numerous methods known to those skilled in the art including but not limited to injection of the potting compound using a syringe and needle. In certain embodiments, one or more of the cartridge faces on the housing unit are removed, or not assembled, and the potting compound is poured or injected into the housing unit in a sufficient amount to envelop at least a portion or all surfaces of the fluid separation conduit, more preferably enveloping substantially all surfaces, e.g. outer surfaces, of the fluid separation conduit that are located internally within the housing unit. In other embodiments, the potting compound is disposed in the conduit cartridge prior to, or simultaneously with, insertion of a fluid separation conduit into the housing unit. The cartridge can then be packed with a suitable packing material, e.g. a suitable stationary phase, based on the intended use of the fluid separation conduit cartridge. Numerous methods for loading stationary phases are well known to those skilled in the art and include, for example, those mentioned here. Following the packing of the cartridge, the cartridge can undergo testing for quality assurance at the manufacturing facility, e.g. testing to assess cartridge quality and operation at high pressures. In accordance with another aspect, a fluid separation conduit cartridge comprises at least a housing unit, a fluid separation conduit within the housing unit, an inlet orifice in fluid communication with a first end of the fluid separation conduit, and an encryption device. As used here, an encryption device is any device which is operative, either alone or in combination with other devices or components elsewhere, to perform an encryption operation on information, e.g. a signal containing or corresponding to a method, e.g. an LC method, to be performed by the cartridge and/or other components of a system comprising the cartridge, or a signal containing or corresponding to test results obtained by the cartridge or a system comprising the cartridge, e.g. test results from a detector in fluid communication with the cartridge, etc. Thus, information, as used here, can include but is not limited to data that is acquired by a cartridge, data that is acquired by an instrument, data that is acquired by an analytical system, methods that are used by an instrument, system or a conduit cartridge, messages that are sent from a conduit cartridge to a system, e.g. an instrument, or from a system to a conduit cartridge, methods or data that are sent from a conduit cartridge to a remote operating facility, methods or data that are sent from a operating facility to a remote conduit cartridge, quality control and assurance protocols used by an instrument or a conduit cartridge, corporate trade secrets, manufacturing protocols, manufacturing records, records of cartridge use, and any other parameters or data that a conduit cartridge might use or need for chemical, biological, biochemical, or environmental analyses and separations. Exemplary encryption operations performed by the encryption device include encryption, decryption, or both, such as operations to compress, to encrypt, to transmit, to receive, and/or to decrypt information. For convenience, an encryption device is in some cases below as an encrypting device; likewise reference is made below in some cases to encrypting and/or to decrypting rather than to the more generic ��encryption operation�� but will be understood from context to refer to the more generic concept.
The fluid separation conduit cartridge typically interfaces with an analytical system through a manifold, e.g. the multi-layer laminated manifold 976 shown in FIG. 23. In FIG. 23, the conduit cartridge 972 will be understood to be analogous to conduit cartridge 960 shown in FIG. 22. The manifold 976 is seen in the particular embodiment of FIG. 23 to be a multi-layer laminated structure and has one or more microfluidic channels for introducing fluid into or receiving fluid from the fluid separation conduit cartridge. For example, the manifold 976 may comprise a first layer 978 attached to a second layer 979 which itself is attached to a third layer 980. As can be seen in FIG. 23, the second layer 979 typically is sandwiched between the first layer 978 and the third layer 980. Fluid channels can be provided within and/or at the interface(s) of the layers of such manifolds. For example, layer 979 in the manifold 976 of FIG. 23 can optionally be constructed as a microfluidic substrate assembly described in commonly assigned U.S. Patent Application No. 60/239,010 titled ��Microfluidic Substrate Assembly and a Method of Making Same�� and filed on Oct. 06, 2000, the entire disclosure of which is hereby incorporated herein by reference for all purposes. The layers of the multi-layer laminated manifold each can be manufactured from any of numerous materials, including but not limited to PEEK, steel, e.g. stainless steel, and the like. Different layers of the multi-layer laminated manifold may be formed of different materials. In certain embodiments, the microfluidic flow channel is between two or more of the layers, e.g. the microfluidic flow channel can extend from the third layer into the second layer and optionally into the first layer, for example. The microfluidic flow channel can be formed in one or more of the layers using numerous techniques, e.g. UV embossing, micro-machining, micro-milling, and the like. For example, a microchannel can be etched into the second layer and the first layer such that when the second layer is assembled to the first layer a fluid-tight microfluidic flow channel is created. As discussed above, the layers can be assembled to form the multi-layer laminated manifold. For example, the layers can be assembled by welding the layers together, optionally with a gasket positioned between the layers, or can be assembled using adhesives and the like. One skilled in the art given the benefit of this disclosure will be able to select suitable methods for assembling the layers of multi-layer laminated manifolds suitable for use with the conduit cartridges disclosed here. Preferably, the manifold comprises at least a first microfluidic channel in fluid communication with a solvent reservoir and with the input orifice of the fluid separation conduit cartridge. Thus solvent may flow into the conduit cartridge through a microfluidic channel in the manifold, e.g. by pumping the fluid into the cartridge using a pump. The manifold can include a second microfluidic channel that is in fluid communication with an output orifice of the conduit cartridge and typically is also in fluid communication with a detector. Therefore, a sample may be introduced into the conduit cartridge through the first microfluidic channel in the manifold, separated by the conduit cartridge, and the separated species can flow out of the conduit cartridge through the second microfluidic channel in the manifold to a detector that can measure the amount and nature of the species present in the sample. One skilled in the art given the benefit of this disclosure will be able to design other suitable manifolds and devices for interfacing the conduit cartridge with an analytical system.
Although the present invention has been described above in terms of specific embodiments, it is anticipated that other uses, alterations and modifications thereof will become apparent to those skilled in the art given the benefit of this disclosure. It is intended that the following claims be read as covering such alterations and modifications as fall within the true spirit and scope of the invention. It is intended that the articles ��a�� and ��an��, as used below in the claims, cover both the singular and plural forms of the nouns which the articles modify.
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