Source: http://www.google.co.uk/patents/US9572985
Timestamp: 2017-10-20 21:53:13
Document Index: 660472203

Matched Legal Cases: ['Application No. 2', 'Application No. 09795810', 'Application No. 2011', 'Application No. 2011', 'Application No. 2011', 'Application No. 10787404', 'Application No. 2012', 'Application No. 201103393']

Patent US9572985 - Method of manufacturing a thin film leadless neurostimulator - Google Patents
The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life. The present disclosure also describes accessories which guide the implantation of the device, and the components...http://www.google.co.uk/patents/US9572985?utm_source=gb-gplus-sharePatent US9572985 - Method of manufacturing a thin film leadless neurostimulator
Publication number US9572985 B2
Application number US 15/194,033
Also published as CA2959281A1, EP3185948A1, US9403011, US20160059016, US20160303375, US20170143982, WO2016030822A1
Publication number 15194033, 194033, US 9572985 B2, US 9572985B2, US-B2-9572985, US9572985 B2, US9572985B2
Patent Citations (731), Non-Patent Citations (82), Classifications (14), Legal Events (1)
US 9572985 B2
1. A method of manufacturing an implantable neurostimulator, the method comprising:
forming a MEMS film comprising a plurality of electrodes and a ribbon cable extending from a distal end of the MEMS film;
coupling a stimulation source with a first plurality of contacts, the first plurality of contacts disposed on a first face of the ribbon cable and in electrical communication with at least one of the plurality of electrodes;
coupling a power supply with a second plurality of contacts, the second plurality of contacts disposed on a second face of the ribbon cable;
folding the ribbon cable toward a face of the MEMS film; and
forming, with the MEMS film, a lumen, the ribbon cable disposed within the lumen.
2. The method of claim 1, further comprising coupling a recording circuit on a third plurality of contacts disposed on the first face of the ribbon cable.
3. The method of claim 1, wherein the first face of the ribbon cable is different than the second face of the ribbon cable.
4. The method of claim 1, further comprising filling the lumen with an encapsulating epoxy.
coupling a lead wire with a tether contact, the tether contact disposed toward a distal tip of the ribbon cable.
6. The method of claim 1, further comprising heat molding the MEMS film to form the lumen.
7. The method of claim 1, wherein the power supply comprises a capacitor.
8. The method of claim 1, wherein the MEMS film includes a first polymeric layer, a metal layer, and a polymeric barrier layer.
9. The method of claim 8, wherein the MEMS film includes a first barrier layer and a second barrier layer.
10. The method of claim 9, wherein the first and second barrier layer comprise titanium and the metal layer comprises platinum.
11. The method of claim 9, wherein the first and second barrier layers comprise at least one of Silicon Nitride, Silicon Oxide, Silicon Carbide, Poly-Silicon, and Amorphous-Silicon.
12. The method of claim 8, wherein the metal layer comprises at least one of gold, platinum, titanium, and copper.
13. The method of claim 8, wherein the metal layer is between 200 nm and 400 nm thick.
a gold layer deposited on each of the first plurality of contacts and the second plurality of contacts.
coupling an antenna to the MEMS film, the antenna configured to operate at a center frequency of one of 6.790 MHz, 13.560 MHz, 27.120 MHz, 40.680 MHz, 433.920 MHz, 915.000 MHz, 2.450 GHz, 5.800 GHz, and 24.125 GHz.
wirelessly charging the power supply.
setting a first subset of the plurality of electrodes as recording electrodes; and
setting a second subset of the plurality of electrodes as stimulating electrodes.
coupling a distal tip with a distal end of the MEMS film.
coupling a tether to the distal tip.
disposing an antenna within the tether.
This application is a divisional application of U.S. patent application Ser. No. 14/470,356, that was filed Aug. 27, 2014 and that issued as U.S. Pat. No. 9,403,011 on Aug. 2, 2016, and which is herein incorporated by reference in its entirety.
FIG. 1B illustrates the leadless stimulator 100 implanted into a patient's brain system 50 with the burr hole cover frame 400 and the external programmer 500 external to the patient's brain. The leadless stimulator 100 can be implanted responsive to the patient having a surgical planning procedure that involves MM and/or CT scans to localize brain targets, thereafter the leadless neurostimulator 100 can be implanted in the deep brain using components of the leadless neurostimulator system 50. The deployment system 305 can push the leadless neurostimulator 100 to the brain target, and subsequently removed leaving the leadless stimulator 100 towards the brain target. The implantable antenna 200 remains remain extra-cranial. The burr hole cover frame 400 is used to fill the burr hole and stabilize the leadless stimulator 100. As described below, in some implementations, implantable antenna 200 is wrapped around the burr hole cover frame 400 to provide the correct diameter for efficient extra-corporeal communication. After implantation and surgical recovery, the external programmer 500 is used to program the leadless stimulator 100. The external programmer 500 can also provide power, or in some implementations recharge, the leadless stimulator 100.
Referring again to FIG. 23N, at step 2363, a power supply is coupled with the MEMS film. As illustrated in FIG. 20A and 20B, a power supply 181 can be coupled with the MEMS film. The power supply can include a plurality of contacts, through which an electrical connection is established with the MEMS film. In some implementations, the power supply is coupled to the same face of the ribbon cable as the stimulation source, and in other implementations the power supply is coupled with a face opposite to the face the stimulation source is coupled. In some implementations, other circuitry such as recording circuitry, control circuitry, or other ASICs can be coupled with the ribbon cable.
FIGS. 26A-26C illustrate an example leg support stent 344. In some implementations, the external diameter of the leg support stent 344 is between about 0.5 mm and about 3 mm, between about 1 mm and about 2 mm, or about 1 mm and 1.85 mm. The internal diameter of the leg support stent 344 can be at least the external diameter of the inner cylinder 330, such that the leg support stent 344 can be disposed around the inner cylinder 330. The leg support stent 344 can include leg supports 342 at distal end of the leg support stent 344. As illustrated, the leg support stent 344 includes four leg supports 342. In some implementations, the leg supports 342 can be flexible enough to expand with the typical forces that can be applied by hand. FIG. 26B and 26C illustrate the expanded leg supports 342. In some implementations, the leg supports 342 of the leg support stent 344 slide distally along the inner cylinder 330. When the leg supports 342 come into contact with the outer wall 341 of the guide 339, the outer wall 341 can cause the leg supports 342 to expand.
FIGS. 31A and 31B illustrate an example deployment mechanism 319. In some implementations, the deployment mechanism 319 can include a handle 325 that can be used to deploy the distal legs 360, as illustrated in FIGS. 30A and 30B. The leg support stent 344 can be attached to the deployment handle 325. Accordingly, movement of the deployment handle 325 can be translated into movement of the leg support stent 344, which results in the deployment or retraction of the distal legs 360. FIG. 31A illustrates the position of the deployment handle 325 when the distal legs 360 are in the deployed state, and FIG. 31B illustrates the position of the deployment handle 325 when the distal legs 360 are in the retracted state. The central lumen 337 is visible on the proximal end of the deployment mechanism 319. The deployment mechanism 319 can include depth stops 320 that can limit the movement of the deployment handle 325 in the proximal and distal directions.
FIGS. 35-38 illustrate an example method of implanting the leadless stimulator 100. FIG. 35A and 35B illustrate the leadless stimulator 100 in the preimplantation position. The leadless stimulator 100 is positioned above a craniotomy 1055 in a patient's skull 1050. The craniotomy exposes a portion of the brain 1060. In some implementations, the leadless stimulator 100 and deployment system 305 are lowered into place from the exterior of the patient using stereotactic implantation tools (not illustrated).
FIGS. 38A and 38B illustrate the placement of the leadless stimulator 100 after the retraction of the deployment system 305. Following the targeting procedure, the distal legs 360 can be retracted. The leadless stimulator 100 can be left in place and the deployment system 305 is retracted from the patient. As the deployment system 305 is retracted, the stimulation capsule 120 remains in place and is tethered with the antenna 200 by the tether 190. The antenna 200 may exit the patient through the craniotomy 1055. The surgeon may fill the craniotomy 1055 with surgical cement or bone paste, which can secure the antenna 200 in place. In some implementations, the antenna 200 is wound into a burr hole cover frame to secure and position the antenna 200.
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International Classification A61N1/05, A61N1/36, A61N1/372, A61N1/378, A61N1/375
Cooperative Classification A61N1/36125, A61N1/37229, A61N1/37211, A61N1/3756, A61N1/0534, A61N1/36135, A61N1/37205, A61N1/0529, A61N1/3787
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MERCANZINI, ANDRE;REEL/FRAME:039021/0051