Source: https://patents.google.com/patent/US8820318
Timestamp: 2018-02-19 14:16:00
Document Index: 204383289

Matched Legal Cases: ['§371', 'Application No. 60', 'art.\n27', 'art.\n29', 'art.\n30', 'art.\n61', 'art.\n63']

US8820318B2 - Drug dispenser - Google Patents
US8820318B2
US8820318B2 US12674063 US67406308A US8820318B2 US 8820318 B2 US8820318 B2 US 8820318B2 US 12674063 US12674063 US 12674063 US 67406308 A US67406308 A US 67406308A US 8820318 B2 US8820318 B2 US 8820318B2
US20110061646A1 (en )
One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer element to move the transfer element from an initial position along the longitudinal axis in a first direction; provided to the container collar, a pre-load mechanism to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome; and connecting the container collar with the transfer element, a biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position.
This application is filed pursuant to 35 U.S.C. §371 as a U.S. National Phase Application of International Patent Application No. PCT/EP2008/060861 filed Aug. 19, 2008, which claims priority from U.S. Provisional Application No. 60/956,950 filed Aug. 21, 2007. The content of each of the preceding applications is specifically incorporated herein by reference.
According to a further aspect of the invention there is provided a loading arrangement for loading a fluid dispensing container into a dispensing mode thereof, comprising:—
In a yet further aspect of the invention there is provided a drug dispenser having a housing which receives the assembly of the invention, the container comprising the container part and the dispensing member, the housing having a support which receives the dispensing member and a latching surface for the latch to latch to latch the first part, and hence the container part, against movement in the first direction, and the dispenser having an outlet through which fluid dispensed from the container part is dispensible from the dispenser and an actuating mechanism for moving the second part of the loading arrangement in the first direction the predetermined distance from the first part for the latch release to release the latch from the latching surface and for the second part to drive the first part in the first direction and consequently move the container part in the first direction relative to the dispensing member for dispensing therefrom through the outlet.
In FIGS. 4 c and 6 e, which corresponds to a fifth stage of operation, such further force has been applied to the levers 20 a, 20 b. The protruding end 21 a, 21 b (see also FIG. 3 a) of each respective lever 20 a, 20 b touches off one against the other, thereby preventing any further lever 20 a, 20 b travel. Most importantly, the flexible legs 34 a, 34 b have flexed and become displaced from their respective steps 18 a, 18 b through the action of the downward movement of the outer ramps 44 a, 44 b. The extension collar 40 now moves instantaneuously downwards, relative to the container collar 30, as a result of its experience of the unrestricted actuating force resulting in the extension collar 40 drivably engaging the stop features 37 a, 37 b provided to container collar 30 to thereby drive the container collar 30 (and hence canister 5 in permanent engagement therewith) rapidly downwards. The valve of the canister 5 is thereby activated to release aerosolized drug through the passage 9 in the stem block 8 which guides that discharged aerosolized drug to the mouthpiece 14 for inhalation by the patient.
Appropriate drugs may thus be selected from, for example, analgesics, e.g., codeine, dihydromorphine, ergotamine, fentanyl or morphine; anginal preparations, e.g., diltiazem; antiallergics, e.g., cromoglycate (e.g. as the sodium salt), ketotifen or nedocromil (e.g. as the sodium salt); antiinfectives e.g., cephalosporins, penicillins, streptomycin, sulphonamides, tetracyclines and pentamidine; antihistamines, e.g., methapyrilene; anti-inflammatories, e.g., beclomethasone (e.g. as the dipropionate ester), fluticasone (e.g. as the propionate ester), flunisolide, budesonide, rofleponide, mometasone e.g. as the furoate ester), ciclesonide, triamcinolone (e.g. as the acetonide) or 6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxy-androsta-1,4-diene-17β-carbothioic acid S-(2-oxo-tetrahydro-furan-3-yl)ester; antitussives, e.g., noscapine; bronchodilators, e.g., albuterol (e.g. as free base or sulphate), salmeterol (e.g. as xinafoate), ephedrine, adrenaline, fenoterol (e.g. as hydrobromide), salmefamol, carbuterol, mabuterol, etanterol, naminterol, clenbuterol, flerbuterol, bambuterol, indacaterol, formoterol (e.g. as fumarate), isoprenaline, metaproterenol, phenylephrine, phenylpropanolamine, pirbuterol (e.g. as acetate), reproterol (e.g. as hydrochloride), rimiterol, terbutaline (e.g. as sulphate), isoetharine, tulobuterol or 4-hydroxy-7-[2-[[2-[[3-(2-phenylethoxy)propyl]sulfonyl]ethyl]amino]ethyl-2(3H)-benzothiazolone; adenosine 2a agonists, e.g. 2R,3R,4S,5R)-2-[6-Amino-2-(1S-hydroxymethyl-2-phenyl-ethylamino)purin-9-yl]-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol (e.g. as maleate); α4 integrin inhibitors e.g. (2S)-3-[4-({[4-(aminocarbonyl)-1-piperidinyl]carbonyl}oxy}phenyl]-2-[((2S)-4-methyl-2-{[2-(2-methylphenoxy)acetyl]amino}pentanoyl)amino]propanoic acid (e.g. as free acid or potassium salt), diuretics, e.g., amiloride; anticholinergics, e.g., ipratropium (e.g. as bromide), tiotropium, atropine or oxitropium; hormones, e.g., cortisone, hydrocortisone or prednisolone; xanthines, e.g., aminophylline, choline theophyllinate, lysine theophyllinate or theophylline; therapeutic proteins and peptides, e.g., insulin or glucagon; vaccines, diagnostics, and gene therapies. It will be clear to a person skilled in the art that, where appropriate, the drugs may be used in the form of salts, (e.g., as alkali metal or amine salts or as acid addition salts) or as esters (e.g., lower alkyl esters) or as solvates (e.g., hydrates) to optimise the activity and/or stability of the drug.
Suitable bronchodilators are β2-adrenoreceptor agonists, including salmeterol (which may be a racemate or a single enantiomer, such as the R-enantiomer), for instance salmeterol xinafoate, salbutamol (which may be a racemate or a single enantiomer, such as the R-enantiomer), for instance salbutamol sulphate or as the free base, formoterol (which may be a racemate or a single diastereomer, such as the R,R-diastereomer), for instance formoterol fumarate or terbutaline and salts thereof. Other suitable β2-adrenoreceptor agonists are 3-(4-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)hexyl]oxy}butyl)benzenesulfonamide, 3-(3-{[7-({(2R)-2-hydroxy-2-[4-hydroxy-3-hydroxymethyl)phenyl]ethyl}-amino)heptyl]oxy}propyl)benzenesulfonamide, 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl)-2-(hydroxymethyl)phenol, 4-{(1R)-2-[(6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-hydroxyethyl)-2-(hydroxymethyl)phenol, N-[2-hydroxyl-5-[(1R)-1-hydroxy-2-[[2-4-[[(2R)-2-hydroxy-2-phenylethyl]amino]phenyl]ethyl]amino]ethyl]phenyl]formamide, and N-2{2-[4-(3-phenyl-4-methoxyphenyl)aminopheny]ethyl}-2-hydroxy-2-(8-hydroxy-2(1H)-quinolinon-5-yl)ethylamine, and 5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one. Preferably, the β2-adrenoreceptor agonist is a long acting β2-adrenoreceptor agonist (LABA), for example a compound which provides effective bronchodilation for about 12 hours or longer.
Other suitable drug compounds include: cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid (also known as cilomalast) disclosed in U.S. Pat. No. 5,552,438 and its salts, esters, pro-drugs or physical forms; AWD-12-281 from elbion (Hofgen, N. et al. 15th EFMC Int Symp Med Chem (Sept 6-10, Edinburgh) 1998, Abst P.98; CAS reference No. 247584020-9); a 9-benzyladenine derivative nominated NCS-613 (INSERM); D-4418 from Chiroscience and Schering-Plough; a benzodiazepine PDE4 inhibitor identified as CI-1018 (PD-168787) and attributed to Pfizer; a benzodioxole derivative disclosed by Kyowa Hakko in WO99/16766; K-34 from Kyowa Hakko; V-11294A from Napp (Landells, L. J. et al. Eur Resp J [Annu Cong Eur Resp Soc (September 19-23, Geneva) 1998] 1998, 12 (Suppl. 28): Abst P2393); roflumilast (CAS reference No 162401-32-3) and a pthalazinone (WO99/47505, the disclosure of which is hereby incorporated by reference) from Byk-Gulden; Pumafentrine, (−)-p-[(4aR*,10bS*)-9-ethoxy-1,2,3,4,4a,10b-hexahydro-8-methoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]-N,N-diisopropylbenzamide which is a mixed PDE3/PDE4 inhibitor which has been prepared and published on by Byk-Gulden, now Altana; arofylline under development by Almirall-Prodesfarma; VM554/UM565 from Vernalis; or T-440 (Tanabe Seiyaku; Fuji, K. et al. J Pharmacol Exp Ther, 1998, 284(1): 162), and T2585.
(b) an outlet for insertion into a body cavity of a patient extending from said housing;
(c) a drug discharge device provided to the housing and moveable with respect thereto along a longitudinal axis of the drug discharge device, said drug discharge device comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from said container for discharge of said drug formulation towards said outlet;
(d) a container collar connecting to the drug discharge device;
(e) a transfer element connecting to said container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, said transfer element including an actuating portion, wherein the transfer element and the container collar have co-operable drive features which enable the transfer element to be moved along the longitudinal axis in a first direction in driving relationship with the container collar to drive the container collar in the first direction;
(f) at least one finger operable member provided to the housing which is moveable to apply an actuating force to said actuating portion of said transfer element to move the transfer element from an initial transfer element position along the longitudinal axis in the first direction to drive movement of the container collar through the co-operable drive features thereof and so move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism;
(g) a pre-load mechanism provided to the container collar to prevent the transfer of element driving the container collar in the first direction through the co-operable drive features thereof to move said drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until an actuating force of greater than a pre-determined threshold force is applied to the at least one finger operable member; and
2. A drug dispenser device according to claim 1 , wherein the container has a cylindrical form and the longitudinal axis is defined by the central axis of the cylindrical container.
3. A drug dispenser device according to claim 1, wherein the container collar permanently engages with the container.
4. A drug dispenser device according to claim 1, wherein the transfer element comprises an extension collar.
5. A drug dispenser device according to claim 4, wherein the extension collar fits around the container collar.
6. A drug dispenser device according to claim 1, wherein the actuating portion defines an abutment surface.
7. A drug dispenser device according to claim 1, wherein the at least one finger operable member defines a bearing surface for bearing on the actuating portion of the transfer element.
8. A drug dispenser device according to claim 1, wherein the at least one finger operable member comprises a lever.
9. A drug dispenser device according to claim 1, wherein the at least one finger operable member comprises of at least one lever pivotally connected to part of the housing.
10. A drug dispenser device according to claim 9, wherein there are two opposing levers, each of which pivotally connects to part of the housing and is arranged to act upon the transfer element so as to urge the transfer element in the first direction when the two opposing levers are squeezed together by a user.
11. A drug dispenser device according to claim 9, wherein the at least one lever is pivotally supported at a lower end of the housing.
12. A drug dispenser device according to claim 1, wherein the biasing return mechanism comprises at least one spring.
13. A drug dispenser device according to claim 12, wherein the biasing return mechanism comprises an arrangement of two springs locating one on either side of the container collar.
14. A drug dispenser device according to claim 12, wherein the biasing return mechanism comprises at least one extension spring.
15. A drug dispenser device according to claim 1, wherein the pre-load mechanism is formed between the container collar and the housing.
16. A drug dispenser device according to claim 15, wherein the pre-load mechanism comprises at least one detent provided to the container collar for reversible engagement with part of the housing.
17. A drug dispenser device according to claim 16, wherein the at least one detent comprises a flexible support limb.
18. A drug dispenser device according to claim 17, wherein said flexible support limb is arranged for reversible engagement with a step or abutment provided to the housing.
19. A drug dispenser device according to claim 17, wherein the pre-load mechanism comprises an arrangement of from two to four flexible support limbs.
20. A drug dispenser device according to claim 17, wherein a guide mechanism is provided to the transfer element for guiding the disengagement of the flexible support limb.
21. A drug dispenser device according to claim 20, wherein said guide mechanism comprises a guide ramp, which interacts with a shaped head of the flexible support limb.
22. A drug dispenser device according to claim 17, wherein a reseat guide mechanism is provided to the transfer element for guiding the re-engagement of the flexible support limb.
23. A drug dispenser device according to claim 22, wherein said reseat guide mechanism comprises a reseat guide ramp, which interacts with a shaped reseat head of the flexible support limb.
24. A drug dispenser device according to claim 15, wherein the pre-load mechanism comprises at least one detent provided to the housing for reversible engagement with part of the container collar.
25. A drug dispenser device comprising:
a drug discharge device in the housing comprising a container for storing a drug formulation to be dispensed and a discharge mechanism for discharge of said drug formulation from said container towards said outlet, the drug discharge device disposed in the housing such that the discharge mechanism is held stationary and the container is movable in a first direction relative to the discharge mechanism to put the device in a discharge mode where the formulation is discharged from the container towards the outlet;
a transfer arrangement for transferring the container in the first direction relative to the discharge mechanism comprising a first part attached to the container, a second part connected to the first part so that the first and second parts are movable towards and away from each other, wherein the first and second parts are provided with co-operable drive features which enable the second part to be moved in the first direction in driving relationship with the first part to drive the first part in the first direction, a return biasing force mechanism for biasing the first and second parts to a resting configuration thereof, a latch adapted in use to latch the first part against movement in the first direction, and a latch release adapted for releasing the latch, when an actuating force of greater than a pre-determined threshold force is applied to the second part in the first direction, to enable the actuating force to move the second part in the first direction to drive the first part through the co-operable drive features and so carry the container in the first direction relative to the discharge mechanism to put the drug discharge device in its discharge mode.
26. A drug dispenser device according to claim 25, wherein the latch is provided on the first part and the latch release is provided on the second part.
27. A drug dispenser device according to claim 25, wherein the first part is a collar.
28. A drug dispenser device according to claim 25, wherein the first and second parts are each an annular collar, and wherein the annular collars are concentrically arranged with the first part being disposed within the second part.
29. A drug dispenser device according to claim 25, wherein the latch is formed by at least one projection of the first part.
30. A drug dispenser device according to claim 25, wherein the latch release is formed by a surface thereof for contacting the latch for release thereof.
31. A drug dispenser device according to claim 25, wherein the return biasing force is provided by at least one resilient element.
32. A drug dispenser device according to claim 31, wherein the at least one resilient element is a spring.
33. A drug dispenser device according to claim 25, wherein the device has an actuating mechanism for applying the actuating force to the second part of the transfer arrangement in the first direction.
34. A drug dispenser device according to claim 33, wherein the actuating mechanism comprises at least one finger operable member.
35. A drug dispenser device according to claim 34, wherein said at least one finger operable member consists of at least one lever.
36. A drug dispenser device according to claim 1, wherein the drug discharge device is suitable for discharging aerosolized drug and comprises an aerosol canister provided with a discharge valve having a valve stem.
37. A drug dispenser device according to claim 36, wherein said valve stem is received within a stem block provided to the housing, which stem block includes a passage that acts such as to channel discharged aerosolized drug from the valve stem towards the outlet.
38. A drug dispenser device according to claim 36, wherein the outlet defines a mouthpiece.
39. A drug dispenser device according to claim 36, wherein the aerosol canister comprises an aerosol drug formulation comprising a drug in a propellant.
40. A drug dispenser device according to claim 39, wherein said propellant is a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant.
41. A drug dispenser device according to claim 1, wherein the drug discharge device is suitable for discharging a spray of fluid drug and comprises a fluid container provided with a pump having a discharge tube.
42. A drug dispenser device according to claim 1, additionally comprising a drug formulation in the container.
43. A housing assembly for receipt of a drug discharge device, said drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel extending from said container for discharge of said drug formulation, the housing assembly comprising
(a) a housing in which the drug discharge device is receivable for movement along its longitudinal axis relative to the housing;
(d) a transfer element connecting to said container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device when present, said transfer element including an actuating portion, wherein the transfer element and the container collar have co-operable drive features which enable the transfer element to be moved along the longitudinal axis in a first direction in driving relationship with the container collar to drive the container collar in the first direction;
(e) at least one finger operable member provided to the housing which is moveable to apply an actuating force to said actuating portion of said transfer element to move the transfer element from an initial transfer element position along the longitudinal axis in the first direction to drive movement of the container collar through the co-operable drive features thereof and so move the drug discharge device, when present, along the longitudinal axis in the first direction to actuate the discharge mechanism;
(f) a pre-load mechanism provided to the container collar to prevent the transfer element driving movement of the container collar in the first direction through the co-operable drive features thereof to move said drug discharge device, when present, along the longitudinal in the first direction to actuate the discharge mechanism until an actuating force of greater than a pre-determined threshold force is applied to the at least one finger operable member; and
(g) a biasing return mechanism connecting the container collar with the transfer element, the biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to the initial transfer element position.
44. A drug dispenser device according to claim 25, wherein the drug discharge device is suitable for discharging aerosolized drug and comprises an aerosol canister provided with a discharge valve having a valve stem.
45. A drug dispenser device according to claim 44, wherein said valve stem is received within a stem block provided to the housing, which stem block includes a passage that acts such as to channel discharged aerosolized drug from the valve stem towards the outlet.
46. A drug dispenser device according to claim 44, wherein the outlet defines a mouthpiece.
47. A drug dispenser device according to claim 44, wherein the aerosol canister comprises an aerosol drug formulation comprising a drug in a propellant.
48. A drug dispenser device according to claim 47, wherein said propellant is a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant.
49. A drug dispenser device according to claim 25, wherein the drug discharge device is suitable for discharging a spray of fluid drug and comprises a fluid container provided with a pump having a discharge tube.
50. A drug dispenser device according to claim 25, additionally comprising a drug formulation in the container.
51. A drug dispenser device according to claim 1, wherein the co-operable drive features are spaced-apart and wherein when an actuating force of greater than the pre-determined threshold force is applied to the at least one finger operable member the transfer element is moved along the longitudinal axis in the first direction (i) with respect to the container collar to bring the drive feature of the transfer element into engagement with the drive feature of the container collar, and then (ii) in driving relationship with the container collar to drive the container collar in the first direction.
52. A drug dispenser device according to claim 1, wherein the pre-load mechanism has a detent formed between co-operable detent features of the container collar and the housing to prevent the container collar moving in the first direction and wherein the transfer element has a detent release to release the detent and enable the container collar to be driven in the first direction by the transfer element when an actuating force of greater than the pre-determined threshold force is applied to the at least one finger operable member.
53. A drug dispenser device according to claim 52, wherein the detent release physically moves the detent from a detent position to a release position when an actuating force greater than the pre-determined threshold force is applied to the at least one finger operable member.
54. A drug dispenser device according to claim 53, wherein the detent release of the transfer element engages the detent feature of the container collar to prevent the transfer element moving along the longitudinal axis in the first direction until an actuating force of greater than the pre-determined threshold force is applied to the at least one finger operable member.
55. A drug dispenser device according to claim 54, wherein the detent release of the transfer element and the detent feature of the container collar have co-operable cam surfaces for the detent release to cam the detent feature from the detent position to the release position.
56. A drug dispenser device according to claim 52, wherein in a rest position of the container collar the co-operable detent features are spaced-apart and wherein the transfer element drives the container collar from the rest position in the first direction so that the co-operable detent features co-operate to form the detent when an actuating force is applied to the at least one finger operable member.
57. A drug dispenser device according to claim 56, wherein the co-operable drive features of the transfer element and the container collar are first co-operable drive features, wherein the transfer element and the container collar are provided with second co-operable drive features, and wherein the second co-operable drive features engage when an actuating force is applied to the at least one finger operable member so that the transfer element drives the container element from the rest position in the first direction so that the co-operable detent features co-operate to form the detent.
58. A drug dispenser device according to claim 57, wherein the second co-operable drive features are the detent release of the transfer element and the detent feature of the container collar.
59. A drug dispenser device according to claim 25, wherein the co-operable drive features are spaced-apart and wherein upon application of the actuating force greater than then pre-determined threshold force the second part is moved in the first direction (i) with respect to the first part to bring the drive feature of the second part into engagement with the drive feature of the first part, and then (ii) in driving relationship with the first part to drive the first part in the first direction.
60. A drug dispenser device according to claim 26, wherein the latch release and the latch engage to prevent the second part moving along the longitudinal axis in the first direction until an actuating force of greater than the pre-determined threshold force is applied to the second part.
61. A drug dispenser device according to claim 60, wherein the latch and the latch release have co-operable cam surfaces to enable the latch release to release the latch by a cam action.
62. A drug dispenser device according to claim 60, wherein the latch engages with a housing feature to prevent the first part moving in the first direction, wherein in a rest position of the first part the latch and the housing feature are spaced-apart and wherein the second part drives the first part from the rest position in the first direction so that the latch engages the housing feature when an actuating force is applied to the second part.
63. A drug dispenser device according to claim 62, wherein the co-operable drive features are first co-operable drive features, wherein the first and second parts are provided with second co-operable drive features, and wherein the second co-operable drive features engage when an actuating force is applied to the second part so that the second part drives the first part from the rest position in the first direction so that the latch engages the housing feature.
64. A drug dispenser device according to claim 63, wherein the second co-operable drive features are the latch and the latch release.
65. A loading arrangement for loading a fluid dispensing container into a dispensing mode thereof, wherein the fluid dispensing container has a longitudinal axis and is able to be put into the dispensing mode when moved along the longitudinal axis in a first axial direction,
the loading arrangement comprising:—
a first part adapted in use for attachment to the container and movement in the first axial direction to carry the container therewith in the first axial direction for placing the container in the dispensing mode;
a second part adapted in use for movement in the first axial direction;
a latch adapted in use to latch the first part against movement in the first axial direction; and
a latch release adapted for releasing the latch, when the second part has moved with respect to the first part a predetermined distance in the first axial direction,
wherein the first and second parts are provided with co-operable drive features adapted in use to come into engagement from a spaced-apart position on movement of the second part in the first axial direction with respect to the first part so that after the latch is released the second part is able to drive the first part in the first axial direction for placing the fluid dispensing container into its dispensing mode.
66. The loading arrangement according to claim 65, wherein the second part is only able to move the predetermined distance with respect to the first part upon application of greater than a predetermined threshold force thereto and wherein the application of greater than the predetermined threshold force causes the second part to continue to move in the first axial direction after release of the latch so as to drive the first part in the first axial direction through the drive features.
67. The loading arrangement according to claim 66, wherein the latch is provided on the first part and the latch release is provided on the second part and wherein a force greater than the predetermined force is the force required to be applied for the latch to be released.
68. The loading arrangement according to claim 67, wherein the latch release is formed by a surface of the second part for contacting the latch for release thereof.
69. The loading arrangement according to claim 65, wherein the fluid dispensing container has a container part for a fluid, to which the first part is attachable, and a dispensing member through which fluid inside the container part is dispensible therefrom and wherein the fluid dispenser container is placed in its dispensing mode for dispensing through the dispensing member on movement of the container part in the first axial direction relative to the dispensing member.
70. The loading arrangement according to claim 65 configured for use in a hand-held, hand-operable breath-coordinated metered dose inhaler.
71. The loading arrangement of claim 65, wherein the co-operable drive features are adapted to come into engagement after the latch is released.
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