Source: http://www.google.fr/patents/US9511187
Timestamp: 2017-11-21 12:16:45
Document Index: 534480448

Matched Legal Cases: ['Application No. 60', 'Application No. 200780020245', 'Application No. 2014', 'Application No. 01988242', 'Application No. 2014', 'application No. 2009202856']

Brevet US9511187 - Hydraulically actuated pump for fluid administration - Google Brevets
A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the...http://www.google.fr/patents/US9511187?utm_source=gb-gplus-shareBrevet US9511187 - Hydraulically actuated pump for fluid administration
Numéro de publication US9511187 B2
Numéro de demande US 14/809,436
Date de dépôt 27 juil. 2015
Autre référence de publication CA2523267A1, CA2523267C, CA2820537A1, CA2820537C, EP1617888A2, US7530968, US8070726, US9072828, US9125983, US20050119618, US20090157005, US20090198185, US20100217191, US20150328400, US20170035966, WO2004094823A2, WO2004094823A3
Numéro de publication 14809436, 809436, US 9511187 B2, US 9511187B2, US-B2-9511187, US9511187 B2, US9511187B2
Inventeurs Robert R. Gonnelli, Devin V. McAllister, Steven F. Levesque
Cessionnaire d'origine Valeritas, Inc.
Citations de brevets (863), Citations hors brevets (27), Classifications (27), Événements juridiques (1)
US 9511187 B2
A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.
a hydraulic pump chamber having a rigid sidewall containing and contacting hydraulic fluid configured to urge a piston in a fluid reservoir to deliver fluid within the fluid reservoir to a patient;
a first hydraulic reservoir chamber having a first amount of the hydraulic fluid and coupled between the first actuator and the hydraulic pump chamber, the first actuator being configured to urge the hydraulic fluid in the first hydraulic reservoir chamber into the hydraulic pump chamber;
a flow restrictor fluidly coupling the first hydraulic reservoir chamber and the hydraulic pump chamber;
a second hydraulic reservoir chamber having a second amount of the hydraulic fluid and fluidly coupled with the hydraulic pump chamber; and
a second actuator configured to urge the hydraulic fluid from the second hydraulic reservoir chamber into the hydraulic pump chamber, independent of the first actuator.
2. The fluid delivery device of claim 1, wherein the flow restrictor and the first actuator are configured to transfer the hydraulic fluid from the first hydraulic reservoir chamber to the hydraulic pump chamber to deliver the fluid from the fluid reservoir at a sustained basal rate.
3. The fluid delivery device of claim 2, wherein the sustained basal rate is constant.
4. The fluid delivery device of claim 2, wherein the sustained basal rate is over a period of more than 5 hours.
5. The fluid delivery device of claim 2, wherein the sustained basal rate is over a period of approximately 24 hours.
6. The fluid delivery device of claim 2, wherein the second actuator is configured to selectably transfer the hydraulic fluid from the second hydraulic reservoir chamber into the hydraulic pump chamber at discrete intervals to deliver a bolus dosage of the fluid in addition to the sustained basal rate.
7. The fluid delivery device of claim 1, wherein the first and second actuators are compression springs.
8. The fluid delivery device of claim 1, wherein the first and second actuators are coupled to the hydraulic pump chamber in parallel.
9. The fluid delivery device of claim 1, wherein the first actuator includes two or more springs.
10. The fluid delivery device of claim 1, wherein the hydraulic fluid has a viscosity of approximately ISO VG 1500 or more when in use.
11. The fluid delivery device of claim 1, further comprising a moveable piston separating the hydraulic pump chamber and the second actuator.
12. The fluid delivery device of claim 1, wherein the second hydraulic reservoir is positioned between the second actuator and the hydraulic pump chamber.
13. The fluid delivery device of claim 1, wherein the flow restrictor is a fixed aperture.
the piston, the piston configured to sealingly slide along an inner wall of a hydraulic housing and separate the hydraulic housing into the hydraulic pump chamber having the rigid sidewall and the fluid reservoir.
The present application is a continuation of U.S. application Ser. No. 12/762,307, (now U.S. Pat. No. 9,125,983), filed on Apr. 17, 2010, which is a continuation of U.S. application Ser. No. 12/336,363 (now U.S. Pat. No. 8,070,726), filed on Dec. 16, 2008, which is a continuation of U.S. application Ser. No. 10/831,354 (now U.S. Pat. No. 7,530,968), filed on Apr. 23, 2004, which claims the benefit of U.S. Provisional Application No. 60/465,070, filed on Apr. 23, 2003, all of which are incorporated herein by reference in their entirety.
The restrictor, in one embodiment, may be a hydraulic fluid aperture and may be a fixed micro-aperture of approximately 0.1-10 μm in diameter, or about 1-5 μm in diameter, and one ten-thousandths of an inch (0.0001″, or about 2.5 μm) in diameter. In another embodiment, the hydraulic fluid aperture may be an adjustable aperture providing either continuous orate p-wise diameter variations of approximately 0.1-10 μm in diameter, or about 1-5 μm in diameter, preferably one ten-thousandths of an inch (0.0001″, or about 2.5 μm) in diameter. Combined with a hydraulic fluid of appropriate viscosity, the micro-aperture provides precise pressure regulation that is insensitive to ambient pressure or other environmental conditions. This insensitivity, in turn, allows for highly accurate dosing and dose regulation under a wider range of conditions than previously seen in the arts.
Thus one aspect of the invention provides a hydraulically actuated fluid delivery system for sustained delivery of a liquid component, comprising: a pump chamber, and a fluid storage chamber having an orifice and being functionally connected to said pump chamber by a moveable barrier; a hydraulic fluid reservoir for storing a high viscosity fluid, said reservoir being connected to said pump chamber, via a restrictor, such as an aperture, which may be less than 10 μm in diameter, and the largest insoluble particle, if any, in said hydraulic fluid may optionally be no more than the size of said aperture; and, an actuator functionally connected to said hydraulic fluid reservoir to cause said hydraulic fluid to flow into said pump chamber through said aperture, thereby expanding the volume of said pump chamber, displacing said moveable barrier and causing a quantity of said liquid component stored in said fluid storage chamber to be delivered at a sustained rate.
FIGS. 4A-4C are high-level functional schematic drawings of several fluid delivery system with various barriers.
FIGS. 8A-8B are a high-level functional schematic drawings of several fluid delivery system with multiple actuators, according to one embodiment of the invention.
An illustrative embodiment of the hydraulic fluid system described herein is shown in the high-level functional drawing of FIG. 1. The pump chamber 110 may be shaped like, but is not limited to, a cylinder. The hatched lines represent a moveable barrier 130, which may (but need not (o) be at the distal end of aperture 152. Hydraulic fluid 112 enters aperture 152 on pump chamber wall 150 into pump chamber 110, optionally via a connective passage 116.
Viscosity is ordinarily expressed in terms of the time required for a standard quantity of the fluid at a certain temperature to flow through a standard orifice. The higher the value, the more viscous the fluid. Since viscosity varies inversely with temperature, its value is less meaningful unless accompanied by the temperature at which it is determined. As used herein, “high viscosity” means the working fluid has a viscosity grade of at least about ISO VG 20, or at least about ISO VG 32, or at least about ISO VG 50, or at least about ISO VG 150, or at least about ISO VG 450, or at least about ISO VG 1000, or at least about ISO VG 1500.
The hydraulic pump system can be employed in a fluid delivery system that can be manufactured inexpensively, and could take advantage of the slow, yet relatively constant delivery rate associated with the hydraulic pump system. Partly due to the slow rate of delivery, the fluid delivery system can be used to continuously deliver a fluid over a long period of time, e.g. 6 hrs, 12 hrs, 1 clay, 3 days, 5 days, 10 days, one month, etc. The fluid delivery system comprises the hydraulic pump, coupled to a separate chamber for storing fluid to be delivered (the “fluid storage chamber” or “fluid chamber” in short). There could be various mechanisms coupling the movement of the barrier mechanism in the hydraulic pump to the fluid chamber, such that a small amount of fluid (ideally equal to, or at least proportional to the amount of the working fluid entering the hydraulic pump chamber) is expelled from the fluid chamber, through one or more orifice, in response to the movement of the barrier.
The following description is for principal illustration only and should not be construed as limiting in any respect. Various illustrative alternative embodiments are described further below.
FIGS. 3A-3B are schematic diagrams illustrating one advantage of the fluid delivery system, e.g., its ability to tolerate relatively large variations in force generating the over-pressure, to create a relatively constant fluid delivery rate over time or distance traveled by the barrier piston. It is apparent that without the hydraulic pump system, any direct use of force to expel fluid in the fluid chamber will be hard to control, and will be subjected to a large variation in delivery rate of the fluid (FIG. 3A). In contrast, with the hydraulic pump, the delivery rate is much more constant (FIG. 3B).
In one embodiment, as shown in FIG. 6A, one or more external spring(s) 135D having a constant spring coefficient over its full range of motion is (are) employed, (For the sake of simplicity, a single spring configuration is described. But multiple springs may be used to adjust forces.) This spring is disposed so as to connect portions of plates 135A and 135B distant from hinge 135C and to draw them together (inwardly), thus bearing on reservoir 114. Thus, when the system is initially prepared for use, the spring is extended (i.e., placed in tension) by forcing plates 135A and 135B apart. The plates are then held in place with a removable brace or other device (not shown) to keep them from compressing hydraulic reservoir 114. Once the pump is in place and connected through infusion means 160 (see FIG. 2, but not shown here) to inject the medicament into the patient, the brace may be removed. The constant spring tension placed on plates 135A and 135B of actuator 135 will then slowly force the plates together and squeeze hydraulic fluid 112 out of reservoir 114 in a peristalsis-like action.
In an alternate embodiment of the system, two or more hydraulic reservoirs and actuators are provided (FIGS. 8A-8B). In an illustrative embodiment shown in FIG. 8A, the first reservoir 400 and actuator 235 are the same as or similar to items 114 and 135 in FIG. 2. The second reservoir 500 and actuator 235, which may use the same peristaltic actuator 135 as shown in FIG. 2 or any other conventional alternative, such as those described above, are provided with a separate control. In other words, the second actuator may be controlled independently of the first. Both fluid reservoirs are connected to the pump chamber wall 150, through apertures 154 and 156, respectively. The connection may optionally go through connective passages 116. Such a configuration is useful in situations where special, discrete doses of the medicament may be necessary. For example, an insulin-dependent diabetic may often find it necessary to receive an additional booster dose or bolus of insulin immediately after meals, in addition to and along with continuously supplied insulin during the day. The second actuator control may thus be operated independently of the first actuator control mechanism to deliver the bolus.
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Classification internationale A61M5/145, A61M5/142, A61M37/00, A61M1/10, F04B15/02, F04B9/109, A61M1/00, A61M5/155
Classification coopérative F04B9/1095, F04B15/02, A61M5/16877, A61M2250/00, A61M5/1452, A61M5/14526, F04B53/16, F04B53/14, F04B9/103, A61M2037/0046, A61M2037/0038, A61M37/0015, A61M5/155, A61M2005/14264, A61M2005/14513, A61M5/14593, A61M1/1032, A61M2037/0023, A61M2005/14506
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