Source: http://www.google.com/patents/US5798491?dq=7,453,150
Timestamp: 2016-04-29 20:26:07
Document Index: 143246266

Matched Legal Cases: ['art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1']

Patent US5798491 - Multi-mechanistic chemical cleavage using certain metal complexes - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe invention is directed to a particular class of metal complexes, specifically certain texaphyrin metal complexes, which both hydrolyze and photocleave RNA, and which also both hydrolyze RNA and photocleave DNA. In one embodiment, the present invention is directed to a method for both hydrolyzing and...http://www.google.com/patents/US5798491?utm_source=gb-gplus-sharePatent US5798491 - Multi-mechanistic chemical cleavage using certain metal complexesAdvanced Patent SearchPublication numberUS5798491 APublication typeGrantApplication numberUS 08/458,347Publication dateAug 25, 1998Filing dateJun 2, 1995Priority dateJun 9, 1993Fee statusLapsedAlso published asCA2221128A1, DE69601624D1, DE69601624T2, EP0820462A1, EP0820462B1, WO1996038461A1Publication number08458347, 458347, US 5798491 A, US 5798491A, US-A-5798491, US5798491 A, US5798491AInventorsDarren Magda, Jonathan L. SesslerOriginal AssigneeBoard Of Regents, The University Of Texas System, Pharmacyclics, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (60), Non-Patent Citations (248), Referenced by (24), Classifications (41), Legal Events (9) External Links: USPTO, USPTO Assignment, EspacenetMulti-mechanistic chemical cleavage using certain metal complexes
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4318825 *Aug 18, 1980Mar 9, 1982Frame Robert RCatalytic composite, and method of manufactureUS4647447 *Jan 23, 1984Mar 3, 1987Schering AktiengesellschaftDiagnostic mediaUS4835263 *Dec 18, 1986May 30, 1989Centre National De La Recherche ScientifiqueNovel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis and their useUS4878891 *Jun 25, 1987Nov 7, 1989Baylor Research FoundationMethod for eradicating infectious biological contaminants in body tissuesUS4880008 *May 7, 1986Nov 14, 1989The General Hospital CorporationVivo enhancement of NMR relaxivityUS4883790 *Apr 23, 1987Nov 28, 1989University Of British ColumbiaWavelength-specific cytotoxic agentsUS4899755 *May 8, 1985Feb 13, 1990The General Hospital CorporationHepatobiliary NMR contrast agentsUS4915683 *Mar 10, 1987Apr 10, 1990The Medical College Of Wisconsin, Inc.Antiviral method, agents and apparatusUS4935498 *Mar 6, 1989Jun 19, 1990Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS4959363 *Jun 23, 1989Sep 25, 1990Sterling Drug Inc.Quinolonecarboxamide compounds, their preparation and use as antivirals.US4977177 *Apr 30, 1985Dec 11, 1990Nippon Petrochemicals Company, Ltd.Tetrapyrrole polyaminomonocarboxylic acid therapeutic agentsUS5021236 *Mar 2, 1987Jun 4, 1991Schering AktiengesellschaftMethod of enhancing NMR imaging using chelated paramagnetic ions bound to biomoleculesUS5030200 *Nov 6, 1989Jul 9, 1991Baylor Research FoundationMethod for eradicating infectious biological contaminants in body tissuesUS5041078 *Dec 21, 1989Aug 20, 1991Baylor Research Foundation, A Nonprofit Corporation Of The State Of TexasPhotodynamic viral deactivation with sapphyrinsUS5120411 *Dec 21, 1989Jun 9, 1992Board Of Regents, The University Of Texas SystemPhotodynamic activity of sapphyrinsUS5141911 *Aug 7, 1990Aug 25, 1992Societe Nationale Elf AquitaineOxidation catalysts based on supported metalloporphyrinUS5162509 *Jun 18, 1990Nov 10, 1992Board Of Regents, The University Of Texas SystemProcess for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS5242797 *Jan 2, 1992Sep 7, 1993Myron J. BlockNucleic acid assay methodUS5252720 *Jan 21, 1992Oct 12, 1993Board Of Regents, The University Of Texas SystemMetal complexes of water soluble texaphyrinsUS5256399 *May 7, 1992Oct 26, 1993Board Of Regents, The University Of Texas SystemAromatic pentadentate expanded porphyrins in magnetic resonance imagingUS5272056 *Jan 3, 1991Dec 21, 1993The Research Foundation Of State University Of New YorkModification of DNA and oligonucleotides using metal complexes of polyaza ligandsUS5272142 *May 7, 1992Dec 21, 1993Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumorsUS5292414 *Apr 20, 1992Mar 8, 1994Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles for singlet oxygen productionUS5302714 *Oct 26, 1992Apr 12, 1994Board Of Regents, The University Of Texas SystemSapphyrins, derivatives and synthesesUS5369101 *Dec 16, 1993Nov 29, 1994Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS5371199 *Aug 14, 1992Dec 6, 1994The Trustees Of The University Of PennsylvaniaSubstituted porphyrins, porphyrin-containing polymers, and synthetic methods thereforUS5432171 *Jul 28, 1993Jul 11, 1995Board Of Regents, The University Of Texas SystemWater soluble texaphyrin metal complexes for viral deactivationUS5439570 *Aug 25, 1993Aug 8, 1995Board Of Regents, The University Of Texas SystemWater soluble texaphyrin metal complexes for singlet oxygen productionUS5451576 *Aug 25, 1993Sep 19, 1995Board Of Regents, The University Of Texas SystemTumor imaging and treatment by water soluble texaphyrin metal complexesUS5457183 *Oct 12, 1993Oct 10, 1995Board Of Regents, The University Of Texas SystemHydroxylated texaphyrinsUS5457195 *Oct 21, 1992Oct 10, 1995Board Of Regents, The University Of Texas SystemSapphyrin derivatives and conjugatesUS5543514 *Apr 6, 1995Aug 6, 1996Board Of Regents, The University Of Texas SystemWater-soluble sapphyrinsUS5559207 *Apr 14, 1994Sep 24, 1996Board Of Regents, University Of TexasTexaphyrin metal complex mediated ester hydrolysisUS5565552 *Jun 7, 1995Oct 15, 1996Pharmacyclics, Inc.Method of expanded porphyrin-oligonucleotide conjugate synthesisUS5567687 *Sep 21, 1994Oct 22, 1996University Of TexasTexaphyrins and uses thereofUS5587371 *Jun 2, 1995Dec 24, 1996Pharmacyclics, Inc.Texaphyrin-oligonucleotide conjugatesUS5587478 *Mar 15, 1995Dec 24, 1996Board Of Regents, The University Of Texas SystemSapphyrin multimersUS5594136 *May 3, 1995Jan 14, 1997Pharmacyclics, Inc.Texaphyrin solid supports and devicesUS5595726 *Jun 7, 1995Jan 21, 1997Pharmacyclics, Inc.Chromophore probe for detection of nucleic acidUS5599923 *Feb 15, 1994Feb 4, 1997Board Of Regents, University Of TxTexaphyrin metal complexes having improved functionalizationUS5599928 *Jun 2, 1995Feb 4, 1997Pharmacyclics, Inc.Texaphyrin compounds having improved functionalizationUS5607924 *Jun 6, 1995Mar 4, 1997Pharmacyclics, Inc.DNA photocleavage using texaphyrinsUS5622946 *May 10, 1995Apr 22, 1997Pharmacyclics, Inc.Radiation sensitization using texaphyrinsEP0111418A2 *Dec 6, 1983Jun 20, 1984Edelson, Richard L., Dr.System for externally treating the bloodEP0196515A1 *Mar 13, 1986Oct 8, 1986Baxter Travenol Laboratories, Inc.Photodynamic inactivation of virus in therapeutic protein compositionsEP0214908A1 *Sep 2, 1986Mar 18, 1987Centre National De La Recherche Scientifique (Cnrs)Compounds containing an oligonucleotide sequence linked to an intercalating agent and to an activable chemical group, their synthesis and applications to artificial sequence-specific nucleasesEP0233702A2 *Jan 16, 1987Aug 26, 1987Teijin LimitedStretchable synthetic polymer composite filamentFR2697254A1 * Title not availableWO1990001208A1 *Jul 28, 1989Feb 8, 1990Best Industries, Inc.Device and method for encapsulating radioactive materialsWO1990002747A1 *Aug 31, 1989Mar 22, 1990Ultra Diagnostics CorporationRed-shifted phthalocyanine and tetrabenztriazaporphyrin reagentsWO1990010633A1 *Mar 6, 1990Sep 20, 1990Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesWO1991019730A1 *Jun 3, 1991Dec 26, 1991Monsanto CompanyRna hydrolysis/cleavageWO1992001781A1 *Jun 27, 1991Feb 6, 1992The Regents Of The University Of CaliforniaAntibody-mediated cofactor-driven reactionsWO1993014093A1 *Jan 7, 1993Jul 22, 1993Board Of Regents, The University Of Texas SystemMetal complexes of water soluble texaphyrinsWO1994009003A1 *Oct 18, 1993Apr 28, 1994Board Of Regents, The University Of Texas SystemSapphyrin derivatives, conjugates and polymers thereof and expanded porphyrin chromatographic supportsWO1994029316A2 *Jun 9, 1994Dec 22, 1994Board Of Regents, The University Of Texas SystemTexaphyrin metal complex mediated ester hydrolysisWO1995021845A1 *Feb 15, 1995Aug 17, 1995Board Of Regents, The University Of Texas SystemTexaphyrin metal complexes having improved functionalizationWO1995029702A1 *Apr 28, 1995Nov 9, 1995Board Of Regents, The University Of Texas SystemTexaphyrin solid-supports and devicesWO1996007667A1 *Aug 30, 1995Mar 14, 1996Novartis AgOligonucleotide conjugates, compositions and methods for splitting ribonucleic acidsWO1996009315A1 *Sep 21, 1995Mar 28, 1996Board Of Regents, The University Of Texas SystemDna photocleavage using texaphyrins* Cited by examinerNon-Patent CitationsReference1Abid et al., "Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine-2,6-dicarboxaldehyde and α, ω-Primary Diamines", Inorg. Chim. Acta, 95:119-125, 1984.2 *Abid et al., Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine 2,6 dicarboxaldehyde and , Primary Diamines , Inorg. Chim. Acta , 95:119 125, 1984.3Acholla et al., "A Binucleating Accordian Tetrapyrrole Macrocycle", Tetrahedron Lett., 25:3269-3270, 1984.4Acholla et al., "Binucleating Tetrapyrrole Macrocycles", J. Am. Chem. Soc., 107:6902-6908, 1985.5 *Acholla et al., A Binucleating Accordian Tetrapyrrole Macrocycle , Tetrahedron Lett. , 25:3269 3270, 1984.6 *Acholla et al., Binucleating Tetrapyrrole Macrocycles , J. Am. Chem. Soc. , 107:6902 6908, 1985.7Agrawal and Tang, "Efficient Synthesis of Oligoribonucleotide and Its Phosphorothioate Analogue Using H-Phosphonate Approach," Tetrahedron Letters, 31(52):7541-7544, 1990.8Agrawal et al., "Cellular Uptake and Anti-HIV Activity of Oligonucleotides and Their Analogs," Gene Regulation: Biology of Antisense RNA and DNA, 273-283, 1992.9Akhtar et al., "Pharmaceutical Aspects of the Biological Stability and Membrane Transport Characteristics of Antisense Oligonucleotides," Gene Regulation: Biology of Antisense RNA and DNA, 133-145, 1992.10Ansell, "X-Ray Crystal Structure of the Pentagonal Bipyramidal Nickel (11) Complex Ni11 (L)(H2 O)2 ! (BF4)2 and the Selective Stabilisation of the Nickel (1) Oxidation State by a Quinquedentate Macrocyclic Ligand", J. Chem. Soc., Chem. Commun. pp. 546-547, 1982.11 *Ansell, X Ray Crystal Structure of the Pentagonal Bipyramidal Nickel (11) Complex Ni 11 (L)(H 2 O) 2 (BF 4 ) 2 and the Selective Stabilisation of the Nickel (1) Oxidation State by a Quinquedentate Macrocyclic Ligand , J. Chem. Soc., Chem. Commun. pp. 546 547, 1982.12Aoyama et al., "Multi-Point Interaction of Phosphates with Protonated Pyridylporphyrin. Discrimination of Monoalkyl and Dialkyl Phosphates," Chemistry Letters, 1241-1244 (1991).13 *Aoyama et al., Multi Point Interaction of Phosphates with Protonated Pyridylporphyrin. Discrimination of Monoalkyl and Dialkyl Phosphates, Chemistry Letters , 1241 1244 (1991).14Basile et al., "Metal-Activated Hydrolytic Cleavage of DNA," J. Am. Chem. Soc., 109:7550-7551, 1987.15Bauer et al., "Sapphyrins: Novel Aromatic Pentapyrrolic Macrocyces", J. Am. Chem. Soc., 105:6429-6436, 1983.16 *Bauer et al., Sapphyrins: Novel Aromatic Pentapyrrolic Macrocyces , J. Am. Chem. Soc. , 105:6429 6436, 1983.17Beilstein, "2-Athylamino-2-methyl-propanol-(1)", Beilstein's Handbuch, 4:785, 1950.18 *Beilstein, 2 A thylamino 2 methyl propanol (1) , Beilstein s Handbuch , 4:785, 1950.19Bhan and Miller, "Photo-Cross Linking of Psoralen-Derivatized Oligonucleoside Methylphosphonates to Single-Stranded DNA," Bioconjugate Chem., 1:82-88, 1990.20 *Bhan and Miller, Photo Cross Linking of Psoralen Derivatized Oligonucleoside Methylphosphonates to Single Stranded DNA, Bioconjugate Chem. , 1:82 88, 1990.21Boutorine et al., "Fullerene-Oligonucleotide Conjugates: Photo-Induced Sequence Specific DNA Cleavage", Agnew, Chem. Int. Ed. Engl., 33(23/24):2462-2465, 1994.22 *Boutorine et al., Fullerene Oligonucleotide Conjugates: Photo Induced Sequence Specific DNA Cleavage , Agnew, Chem. Int. Ed. Engl. , 33(23/24):2462 2465, 1994.23Bradley et al., "Antisense Therapeutics," Gene Regulation: Biology of Antisense RNA and DNA, 285-293, 1992.24Breslow et al., "Effects of Metal Ions, Including Mg2+ and Lanthanides, on the Cleavage of Ribonucleotides and RNA Model Compounds," Proc. Natl. Acad. Sci. USA, 88:4080-4083, 1991.25Broadhurst et al., "18-and 22-π-Electron Macrocycles Containing Furan, Pyrrole, and Thiophren Rings", J. Chem. Soc., Chem. Commn. pp. 1480-1482, 1969.26Broadhurst et al., "New Macrocyclic Aromatic Systems Related to Porphins", J. Chem. Soc., Chem. Commun. pp. 23-24, 1969.27Broadhurst et al., "Preparation of Some Sulphur-containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso-Thiaphlorin", J. Chem. Soc., Chem. Commun. pp. 807-809, 1970.28Broadhurst et al., "The Synthesis of 22 π-Electron Macrocycles. Sapphyrins and Related Compounds", J. Chem. Soc. Perkin Trans., 1:2111-2116, 1972.29 *Broadhurst et al., 18 and 22 Electron Macrocycles Containing Furan, Pyrrole, and Thiophren Rings , J. Chem. Soc., Chem. Commn. pp. 1480 1482, 1969.30 *Broadhurst et al., New Macrocyclic Aromatic Systems Related to Porphins , J. Chem. Soc., Chem. Commun. pp. 23 24, 1969.31 *Broadhurst et al., Preparation of Some Sulphur containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso Thiaphlorin , J. Chem. Soc., Chem. Commun. pp. 807 809, 1970.32 *Broadhurst et al., The Synthesis of 22 Electron Macrocycles. Sapphyrins and Related Compounds , J. Chem. Soc. Perkin Trans. , 1:2111 2116, 1972.33Brown and Truscott, "New Light on Cancer Therapy," Chemistry in Britain, 955-958, 1993.34 *Brown and Truscott, New Light on Cancer Therapy, Chemistry in Britain , 955 958, 1993.35Browne and Bruice, "Chemistry of Phosphodiesters, DNA and Models. 2. The Hydrolysis of Bis(8-hydroxyquinoline) Phosphate in the Absence and Presence of Metal Ions," Journal of the American Chemical Society, 114(13):4951-4958, 1992.36Cases et al., "Preparation of Hybrid DNA Cleaver-Oligonucleotide Molecules Based on a Metallotris (methylpyridiniumyl) porphyrin Motif," Bioconjugate Chem., vol. 4, No. 5, pp. 366-371, Sep./Oct. 1993.37Chin and Banaszczyk, "Highly Efficient Hydrolytic Cleavage of Adenosine Monophosphate Resulting in a Binuclear Co(III) Complex with a Novel Doubly Bidentate μ4 -Phosphato Bridge," J. Am. Chem. Soc., 111:4103-4105, 1989.38Chin and Banaszczyk, "Rate-Determining Complexation in Catalytic Hydrolysis of Unactivated Esters in Neutral Water," J. Am. Chem. Soc., 111:2724-2726, 1989.39Chin and Zou, "Catalytic Hydrolysis of cAMP," Can. J. Chem., 65:1882-1884, 1987.40Chin et al., "Co(III) Complex Promoted Hydrolysis of Phosphate Diesters: Comparison in Reactivity of Rigid cis-Diaquotetraazacobalt(III) Complexes," J. Am. Chem. Soc., 111:186-190, 1989.41Chung et al., "Synthesis and Characterization of a Reactive Binuclear Co(III) Complex. Cooperative Promotion of Phosphodiester Hydrolysis," Tetrahedron Letters, 31(38):5413-5416, 1990.42Claude et al., "Binding of Nucleosides, Nucleotides and Anionic Planar Substrates by Bis-Intercaland Receptor Molecules," J. Chem. Soc. Chem. Commun., 1991, 17:1182-1185.43 *Claude et al., Binding of Nucleosides, Nucleotides and Anionic Planar Substrates by Bis Intercaland Receptor Molecules, J. Chem. Soc. Chem. Commun. , 1991, 17:1182 1185.44Cohen, Jack S., "Chemically Modified Oligodeoxynucleotide Analogs as Regulators of Viral and Cellular Gene Expression,"Gene Regulation: Biology of Antisense RNA and DNA, 247-259, 1992.45Cramer et al., "Synthesis and Structure of the Chloride and Nitrate Inclusion Complexes of 16-Pyrimidinium crown-4!," J. Am. Chem. Soc., 1991, 113:7033-7034.46 *Cramer et al., Synthesis and Structure of the Chloride and Nitrate Inclusion Complexes of 16 Pyrimidinium crown 4 , J. Am. Chem. Soc. , 1991, 113:7033 7034.47Cuellar et al., "Synthesis and Characterization of Metallo and Metal-Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines", Inorg. Chem., 20:3766-3770, 1981.48 *Cuellar et al., Synthesis and Characterization of Metallo and Metal Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines , Inorg. Chem. , 20:3766 3770, 1981.49Day et al., "Large Metal Ion-Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2-iminoisoindoline)", J. Am. Chem. Soc., 97:4519-4527, 1975.50 *Day et al., Large Metal Ion Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2 iminoisoindoline) , J. Am. Chem. Soc. , 97:4519 4527, 1975.51De Cola et al., "Hexaaza Macrocyclic Complexes of the Lanthanides", Inorg. Chem., 25:1729-1732, 1986.52 *De Cola et al., Hexaaza Macrocyclic Complexes of the Lanthanides , Inorg. Chem. , 25:1729 1732, 1986.53Dervan, Peter B., "Design of Sequence-Specific DNA-Binding Molecules," Science, 232:464-471, 1986.54 *Dervan, Peter B., Design of Sequence Specific DNA Binding Molecules, Science , 232:464 471, 1986.55Dietrich et al., "Proton Coupled Membrane Transport of Anions Mediated by Cryptate Carriers," J. Chem. Soc. Chem. Comm., 1988, 11:691-692.56 *Dietrich et al., Proton Coupled Membrane Transport of Anions Mediated by Cryptate Carriers, J. Chem. Soc. Chem. Comm. , 1988, 11:691 692.57Dixon et al., "Molecular Recognition: Bis-Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters," J. Am. Chem. Soc., 1992, 114:365-366.58 *Dixon et al., Molecular Recognition: Bis Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters, J. Am. Chem. Soc. , 1992, 114:365 366.59Dolphin et al., "Porphocyanine: An Expanded Tetrapyrrolic Macrocycle," J. Am. Chem. Soc., 115:9301-9302, 1993.60 *Dolphin et al., Porphocyanine: An Expanded Tetrapyrrolic Macrocycle, J. Am. Chem. Soc. , 115:9301 9302, 1993.61Dougherty, "Photosensitizers: Therapy and Detection of Malignant Tumors", Photochem. Photobiol., 45:879-889, (1987).62 *Dougherty, Photosensitizers: Therapy and Detection of Malignant Tumors , Photochem. Photobiol. , 45:879 889, (1987).63Dreyer and Dervan, "Sequence-specific Cleavage of Single-Stranded DNA: Oligodeoxynucleotide-EDTA�Fe(II)," Proc. Natl. Acad. Sci. USA, 82:968-972, 1985.64 *Dreyer and Dervan, Sequence specific Cleavage of Single Stranded DNA: Oligodeoxynucleotide EDTA Fe(II), Proc. Natl. Acad. Sci. USA , 82:968 972, 1985.65Ehrenberg et al., "Spectroscopy, Photokinetics and Cellular Effect of Far-Red and Near Infrared Absorbing Photosensitizers," Proc. SPIE-Int. Soc. Opt. Eng 1992, 1645 (Proc. Opt. Methods Tumor Treat. Dect.: Mech. Tech. Photodyn. Ther. . . , 259-263, 1992.66Ehrenberg et al., "The Binding and Photosensitization Effects of Tetrabenzoporphyrins and Texaphyrin in Bacterial Cells," Lasers in Medical Science, 8:197-203, 1993.67 *Ehrenberg et al., Spectroscopy, Photokinetics and Cellular Effect of Far Red and Near Infrared Absorbing Photosensitizers, Proc. SPIE Int. Soc. Opt. Eng 1992, 1645 (Proc. Opt. Methods Tumor Treat. Dect.: Mech. Tech. Photodyn. Ther. . . , 259 263, 1992.68 *Ehrenberg et al., The Binding and Photosensitization Effects of Tetrabenzoporphyrins and Texaphyrin in Bacterial Cells, Lasers in Medical Science , 8:197 203, 1993.69Fasman, "Tentative Rules for Carbohydrate Nomenclature Part 1 (1969)," Handbook of Biochemistry and Molecular Biology, 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio, pp. 100-102.70 *Fasman, Tentative Rules for Carbohydrate Nomenclature Part 1 (1969), Handbook of Biochemistry and Molecular Biology , 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio, pp. 100 102.71Fedorova et al., "Palladium(II)-Coproporphyrin I as a Photoactivable Group in Seequence-Specific Modification of Nucleic Acids by Oligonucleotide Derivatives," FEBS Lett., 259(2):335-337, 1990.72Fiel, Robert J., "Porphyrin-Nucleic Acid Interactions: A Review," Journal of Biomolecular Structure & Dynamics, 6(6):1259-1275, 1989.73 *Fiel, Robert J., Porphyrin Nucleic Acid Interactions: A Review, Journal of Biomolecular Structure & Dynamics , 6(6):1259 1275, 1989.74Furuta et al., "Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base-Pairing Agents," Journal of the American Chemical Society, 1991, 113:4706-4707.75Furuta et al., "Phosphate Anion Binding: Enhanced Transport of Nucleotide Monophosphates Using a Sapphyrin Carrier," J. Am. Chem. Soc., 113:6677-6678, 1991.76 *Furuta et al., Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base Pairing Agents, Journal of the American Chemical Society , 1991, 113:4706 4707.77 *Gal a n et al., A Synthetic Receptor for Dinucleotides, J. Am. Chem. Soc. , 1991, 113:9424 9425.78 *Gal a n et al., Selective Complexation of Adenosine Monophosphate Nucleotides By Rigid Bicyclic Guanidinium Abiotic Receptors, Tetrahedron Letters , 32(15):1827 1830, 1991.79Galan et al., "A Synthetic Receptor for Dinucleotides," J. Am. Chem. Soc., 1991, 113:9424-9425.80Galan et al., "Selective Complexation of Adenosine Monophosphate Nucleotides By Rigid Bicyclic Guanidinium Abiotic Receptors," Tetrahedron Letters, 32(15):1827-1830, 1991.81Goodchild, John, "Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties," Bioconjugate Chemistry, 1(3):165-187, 1990.82 *Goodchild, John, Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties, Bioconjugate Chemistry , 1(3):165 187, 1990.83Gosmann et al., "Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring-Current Effect", Angew. Chem., Int. Ed Engl., 25:1100-1101, (1986).84 *Gosmann et al., Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring Current Effect , Angew. Chem., Int. Ed Engl. , 25:1100 1101, (1986).85Gossauer, "Syntheses of Some Unusual Polypyrrole Macrocycles", Bull. Soc. Chim. Belg., 92:793-795, (1983).86 *Gossauer, Syntheses of Some Unusual Polypyrrole Macrocycles , Bull. Soc. Chim. Belg. , 92:793 795, (1983).87Groves and Farrell, "DNA Cleavage by a Metal Chelating Tricationic Porphyrin," J. Am. Chem. Soc., 111:4998-5000, 1989.88 *Groves and Farrell, DNA Cleavage by a Metal Chelating Tricationic Porphyrin, J. Am. Chem. Soc. , 111:4998 5000, 1989.89Hanvey et al., "Antisense and Antigene Properties of Peptide Nucleic Acids," Science, 258:1481-1485, 1992.90Harriman et al., "Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen", J. Chem. Soc., Chem. Commun., 314-316, 1989. Submitted as A32 in 1449 for UTSB:458.91 *Harriman et al., Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen , J. Chem. Soc., Chem. Commun. , 314 316, 1989. Submitted as A32 in 1449 for UTSB:458.92Hayashi et al., "Site-Selective Hydrolysis of tRNA by Lanthanide Metal Complexes," Inorg. Chem., 32:5899-5900, 1993.93Hendry and Sargeson, "Metal Ion Promoted Phosphate Ester Hydrolysis. Intramolecular Attack of Coordinated Hydroxide Ion," J. Am. Chem. Soc., 111:2521-2527, 1989.94Hisatome et al., "Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine-and Thymine-Porphyrin Derivatives," Chemistry Letters, 1990, 2251-2254.95 *Hisatome et al., Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine and Thymine Porphyrin Derivatives, Chemistry Letters , 1990, 2251 2254.96Hosseini et al., "Multiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysys," J. Am. Chem. Soc., 1990, 112:3896-3904.97Hosseini et al., "Multiple Molecular Recognition and Catalysis. Nucleotide Binding and ATP Hydrolysis by a Receptor Molecule Bearing an Anion Binding Site, an Intercalcator Group, and a Catalytic Site," J. Chem. Soc. Chem. Commun., 1988, 9:596-598.98 *Hosseini et al., Multiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysys, J. Am. Chem. Soc. , 1990, 112:3896 3904.99 *Hosseini et al., Multiple Molecular Recognition and Catalysis. Nucleotide Binding and ATP Hydrolysis by a Receptor Molecule Bearing an Anion Binding Site, an Intercalcator Group, and a Catalytic Site, J. Chem. Soc. Chem. Commun. , 1988, 9:596 598.100International Search Report for related foreign application PCT/US96/08262, date of mailing Sep. 10, 1996.101International Search Report for related foreign application PCT/US96/09419, date of mailing Dec. 17, 1996.102 *International Search Report mailed Dec. 6, 1994.103 *International Search Report mailed Feb. 22, 1994.104 *International Search Report mailed Feb. 3, 1994.105International Search Report mailed Feb. 9, 1996.106Iverson et al., "Interactions Between Expanded Porphyrins and Nucleic Acids," Pure Applied Chemistry, 66(4):845-850, 1994.107 *Iverson et al., Interactions Between Expanded Porphyrins and Nucleic Acids, Pure Applied Chemistry , 66(4):845 850, 1994.108Kim and Chin, "Dimethyl Phosphate Hydrolysis at Neutral pH," J. Am. Chem. Soc., 114:9792-9795, 1992.109Kimura et al., "A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Receptors," J. Org. Chem., 1990, 55(1):46-48.110 *Kimura et al., A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Receptors, J. Org. Chem. , 1990, 55(1):46 48.111Kimura, et al., "Macrocyclic Polyamines as Biological Cation and Anion Complexones -An Application to Calculi Dissolution," Topics in Current Chemistry, 128, Biomimetic and Bioorganic Chemistry VII +265P, Springer-Verlag, Berlin, West Germany, pp. 113, 142, 1985.112 *Kimura, et al., Macrocyclic Polyamines as Biological Cation and Anion Complexones An Application to Calculi Dissolution, Topics in Current Chemistry, 128, Biomimetic and Bioorganic Chemistry VII 265P , Springer Verlag, Berlin, West Germany, pp. 113, 142, 1985.113Knubel et al., "Biomimetic Synthesis of an Octavinylogous Porphyrin with an Aromatic 34! Annulene System", Angew. Chem., Int. Ed. Engl., 27:1170-1172, 1988.114 *Knubel et al., Biomimetic Synthesis of an Octavinylogous Porphyrin with an Aromatic 34 Annulene System , Angew. Chem., Int. Ed. Engl. , 27:1170 1172, 1988.115Kobayashi et al., "Uptake of Chlorophyll-Derivatives by Cellular Nuclei and Mitochondria," Photomed. Photobiol., 15:75-84, 1993.116 *Kobayashi et al., Uptake of Chlorophyll Derivatives by Cellular Nuclei and Mitochondria, Photomed. Photobiol. , 15:75 84, 1993.117Koenig et al., "PDT of Tumor-Bearing Mice Using Liposome Delivered Texaphyrins," International Conference, Milan, Italy, Biosis citation only, Jun. 24-27, 1992.118 *Koenig et al., PDT of Tumor Bearing Mice Using Liposome Delivered Texaphyrins, International Conference, Milan, Italy, Biosis citation only, Jun. 24 27, 1992.119Kolasa et al., "Trivalent Lanthanide Ions Do Not Cleave RNA in DNA-RNA Hybrids", Inorg. Chem., 32:3983-3984, 1993.120Komiyama et al., "Unprecedentedly Fast Hydrolysis of the RNA Dinucleoside Monophosphates ApA and UpU by Rare Earth Metal Ions," J. Chem. Soc. Chem. Commun., 640-641, 1992.121Lauffer, "Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design", Chem. Rev., 87:901-927, 1987.122 *Lauffer, Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design , Chem. Rev. , 87:901 927, 1987.123Le Doan et al., "Sequence-Specific Recognition, Photocrosslinking and Cleavage of the DNA Double Helix by an Oligo- α!-Thymidylate Covalently Attached to an Azidoproflavine," Nucleic Acids Res., 15:7749-7760, 1987.124Le Doan et al., "Sequence-targeted Chemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins," Nucleic Acids Research, 15(21):8643-8659, 1987.125Le Doan et al., "Sequence-Targeted Photochemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins," Bioconjugate Chem., 1:108-113, 1990.126Le Doan et al., "Targeted Cleavage of Polynucleotides by Complementary Oligonucleotides Covalently Linked to Iron-Prophyrins," Biochemistry, 26:6736-6739, 1986.127 *Le Doan et al., Sequence targeted Chemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins, Nucleic Acids Research , 15(21):8643 8659, 1987.128 *Le Doan et al., Targeted Cleavage of Polynucleotides by Complementary Oligonucleotides Covalently Linked to Iron Prophyrins, Biochemistry , 26:6736 6739, 1986.129Lee et al., "Interaction of Psoralen-Derivatized Oligodeoxyribonucleoside Methylphosphonates with Single-Stranded DNA," Biochemistry, 27:3197-3203, 1988.130 *Lee et al., Interaction of Psoralen Derivatized Oligodeoxyribonucleoside Methylphosphonates with Single Stranded DNA, Biochemistry , 27:3197 3203, 1988.131Leff, "Texas `Son-of-Porphyrin` Molecule Lassos Europium to Kill Drug Resistance Gene," BioWorld Today, 5(156):1, 1994.132 *Leff, Texas Son of Porphyrin Molecule Lassos Europium to Kill Drug Resistance Gene, BioWorld Today , 5(156):1, 1994.133LeGoff et al., "Synthesis of a 1,5,1,5! Platyrin, a 26 π-Electron Tetrapyrrolic Annulene", J. Org. Chem. 52:710-711, 1987.134 *LeGoff et al., Synthesis of a 1,5,1,5 Platyrin, a 26 Electron Tetrapyrrolic Annulene , J. Org. Chem. 52:710 711, 1987.135Levina et al., "Photomodification of RNA and DNA Fragments by Oligonucleotide Reagents Bearing Arylazide Groups," Biochimie, 75:25-27, 1993.136Li and Diederich, "Carriers for Liquid Membrane Transport of Nucleotide 5'-Triphosphates," J. Org. Chem.1992, 47:3449-3454.137 *Li and Diederich, Carriers for Liquid Membrane Transport of Nucleotide 5 Triphosphates, J. Org. Chem. 1992, 47:3449 3454.138Lin et al., "Use of EDTA Derivatization to Characterize Interactions between Oligodeoxyribonucleoside Methylphosphonates and Nucleic Acids," Biochemistry, 28:1054-1061, 1989.139 *Lin et al., Use of EDTA Derivatization to Characterize Interactions between Oligodeoxyribonucleoside Methylphosphonates and Nucleic Acids, Biochemistry , 28:1054 1061, 1989.140Magda et al., "Sequence-Specific Photocleavage of DNA by an Expanded Porphyrin with Irradiation Above 700 nm," J. Am. Chem. Soc., 117:3629-3630, 1995.141Magda et al., "Site-Specific Hydrolysis of RNA by Europium (III) Texaphyrin Conjugated to a Synthetic Oligodeoxyribonucleotide," Journal of the American Chemical Society, 116(16):7439-7440, 1994.142 *Magda et al., Site Specific Hydrolysis of RNA by Europium (III) Texaphyrin Conjugated to a Synthetic Oligodeoxyribonucleotide, Journal of the American Chemical Society , 116(16):7439 7440, 1994.143Magda, et al., "Texaphyrin-based nuclease analogs. Rationally designed approaches to the catalytic cleavage of RNA and DNA targets," Chemical Abstracts 125(7):5032 (Aug. 1996).144Maiya et al., "Ground-and Excited-State Spectral and Redox Properties of Cadmium(II) Texaphyrin," Journal of Physical Chemistry, 93(24):8111-8115, 1989.145 *Maiya et al., Ground and Excited State Spectral and Redox Properties of Cadmium(II) Texaphyrin, Journal of Physical Chemistry , 93(24):8111 8115, 1989.146Marks and Stojakowvic, "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato) uranium(VI) and Its Derivatives," J. Am. Chem. Soc., 1978, 1695-1705.147 *Marks and Stojakowvic, Large Metal Ion Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1 iminoisoindolinato) uranium(VI) and Its Derivatives, J. Am. Chem. Soc. , 1978, 1695 1705.148Marks et al., "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato) uranium (VI) and Its Derivatives", J. Am. Chem. Soc., 100:1695-1705, 1978.149 *Marks et al., Large Metal Ion Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1 iminoisoindolinato) uranium (VI) and Its Derivatives , J. Am. Chem. Soc. , 100:1695 1705, 1978.150Mastruzzo et al., "Targeted Photochemical Modification of HIV-Derived Oligoribonucleotides by Antisense Oligodeoxynucleotides Linked to Porphyrins," Photochem. Photobiol., 60(4):316-322, 1994.151Matthews et al., "Inactivation of Viruses with Photoactive Compounds," Blood Cells, 18(1):75-89, 1992.152 *Matthews et al., Inactivation of Viruses with Photoactive Compounds, Blood Cells , 18(1):75 89, 1992.153Menger et al., "Phosphate Ester Hydrolysis Catalyzed by Metallomicelles," J. Am. Chem. Soc., 109:2800-2803, 1987.154Modak et al., "Toward Chemical Ribonucleases. 2. Synthesis and Characterization of Nucleoside-Bipyridine Conjugates. Hydrolytic Cleavage of RNA by Their Copper(II) Complexes," J. Am. Chem. Soc., 113:283-291, 1991.155Mody et al., "Lutetium (III) Texaphyrin: A Novel Photodynamic Therapy Agent," Abstract, 22nd Annual American Society for Photobiology, Scottsdale, AZ, Jun. 25-29, 1994.156 *Mody et al., Lutetium (III) Texaphyrin: A Novel Photodynamic Therapy Agent, Abstract, 22nd Annual American Society for Photobiology , Scottsdale, AZ, Jun. 25 29, 1994.157Morgan and Skalkos, "Second Generation Sensitizers: Where are We and Where Should We Be Going?" Proc. SPIE Int. Soc. Opt. Eng. Ser., 6:87-106, 1990.158Morrow et al., "Efficient Catalytic Cleavage of RNA by Lanthanide(III) Macrocyclic Complexes: Toward Synthetic Nucleases for in Vivo Applications," J. Am. Chem. Soc., 114:1903-1905, 1992.159 *PCT Search Report mailed Feb. 23, 1995.160Perrouault et al., "Sequence-Specific Artificial Photo-Induced Endonucleases Based on Triple Helix-Forming Oligonucleotides," Nature, 344:358-360, 1990.161Phillips and Wasserman, "Promise of Radiosensitizers and Radioprotectors in the Treatment of Human Cancer," Cancer Treatment Reports, 68(1):291-301, 1984.162Pieles and Englisch, "Psoralen Covalently Linked to Oligodeoxyribonucleotides: Synthesis, Sequence Specific Recognition of DNA and Photo-Cross-Linking to Pyrimidine Residues of DNA," Nucleic Acids Res., 17(1):285-299, 1989.163Praseuth et al., "Sequence-Specific Binding and Photocrosslinking of α and β Oligodeoxynucleotides to the Major Groove of DNA via Triple-Helix Formation," Proc. Natl. Acad. Sci. USA, 85:1349-1353, 1988.164Praseuth et al., "Sequence-Targeted Photosensitized Reactions in Nucleic Acids by Oligo-α-Deoxynucleotides and Oligo-β-Deoxynucleotides Covalently Linked to Proflavin," Biochemistry, 27:3031-3038, 1988.165Ranganathan et al., "Design of a Chemical Nuclease Model with (Lys)2 Cu as the Core Motif," Journal of the Chemical Society, 4:337-339, 1993.166Rexhausen et al., "The Synthesis of a New 22 π-Electron Macrocycle: Pentaphyrin", J. Chem. Soc., Chem. Commun., p. 275, 1983.167 *Rexhausen et al., The Synthesis of a New 22 Electron Macrocycle: Pentaphyrin , J. Chem. Soc., Chem. Commun. , p. 275, 1983.168Schmidtchen, "A Non-Macrocyclic Host for Binding Organic Phosphates in Protic Solvents," Tetrahedron Letters, 1989, 30(34):4493-4496.169 *Schmidtchen, A Non Macrocyclic Host for Binding Organic Phosphates in Protic Solvents, Tetrahedron Letters , 1989, 30(34):4493 4496.170Schneider et al., "Catalysis of the Hydrolysis of Phosphoric Acid Diesters by Lanthanide Ions and the Influence of Ligands," Angew. Chem. Int. Ed. Engl., 32(12):1716-1719, 1993.171Seel and Vogtle, "Molecular Recognition and Transport of Nucleobases -Superiority of Macrobicyclid Host Molecules," Angew, Chem. Int. Ed. Engl., 1991, 30(4):442-444.172 *Seel and Vogtle, Molecular Recognition and Transport of Nucleobases Superiority of Macrobicyclid Host Molecules, Angew, Chem. Int. Ed. Engl. , 1991, 30(4):442 444.173Sessler and Burrell, "Expanded Porphyrins," Topics in Current Chemistry, 161:180-273, 1991.174 *Sessler and Burrell, Expanded Porphyrins, Topics in Current Chemistry , 161:180 273, 1991.175Sessler et al., "`Texaphyrin`: A Novel 22 π-Electron Aromatic Pentadentate Macrocyclic Ligand", ACS meeting, Los Angeles, Sep. 1988.176Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate Expanded Porphyrin Ligand", Inorg. Chem., 28:3390-3393, 1989.177Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate", Chem. Absts., 111:720, abstract no. 125716e, Oct. 2, 1989.178Sessler et al., "An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand", J. Am. Chem. Soc., 110:5586-5588, 1988.179Sessler et al., "Anion Binding: A New Direction in Porphyrin-Related Research," Pure & Applied Chem., 65(3):393-398, 1993.180Sessler et al., "Binding of Pyridine and Benzimidazole to a Cadmium Expanded Porphyrin: Solution and X-ray Structural Studies", Inorg. Chem., 28:1333-1341, 1989.181Sessler et al., "Expanded Porphyrins. Receptors for Cationic, Anionic, and Neutral Substrates, in Transition Metals in Supramolecular Chemistry," L. Fabbrizzi and A. Poggi, Editors, NATO ASI Series, Kluwer, Amsterdam, pp. 391-408, 1994.182Sessler et al., "Expanded Porphyrins: The synthesis and Metal Binding Properties of Novel Tripyrrane-Containing Macrocycles", J. Coord. Chem., 18:99-104, 1988.183Sessler et al., "Gadolinium (II) Texaphyrin: A Novel MRI Contrast Agent," Journal of the American Chemical Society, 115(22):10,368-10, 369, 1993.184Sessler et al., "Photodynamic Inactivation of Enveloped Viruses Using Sapphyrin, α 22 π-Electron Expanded Porphyrin: Possible Approaches to Prophylactic Blood Purification Protocols," SPIE Photodynamic Therapy: Mechanisms II. 1203:233-245, 1990.185Sessler et al., "Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.186Sessler et al., "Sapphyrins and Heterosapphyrins," Tetrahedron, 48(44):9661-9672, 1992.187Sessler et al., "Sapphyrins: New Life for an Old Expanded Porphyrin," Synlett, 127-134, 1991.188Sessler et al., "Synthesis and Applications of Schiff-Base Derived Expanded Porphyrins," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.189Sessler et al., "Synthesis and Binding Properties of Monomeric and Dimeric Guanine and Cytosine Amine Derivatives," J. Org. Chem., 1992, 47:826-834.190Sessler et al., "Synthesis and Crystal Structure of a Novel Tripyrrane-Containing Porphyrinogen-like Macrocycle", J. Org. Chem., 52:4394-4397, 1987.191Sessler et al., "Synthesis and Structural Characterization of Lanthanide (III) Texaphyrins," Inorganic Chemistry, 32(14):3175-3187, 1993.192Sessler et al., "Texaphyrins: Synthesis and Applications," Accounts of Chemical Research, 27(2):43-50, 1994.193Sessler et al., "The Coordination Chemistry of Planar Pentadentate Porphyrin-Like Ligands", Comm. Inorg. Chem., 7:333-350, 1988.194Sessler et al., "The Synthesis and Structure of a Novel 22 π-Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Prophyrin", Toronto ACS Meeting, Jun. 1988. USA.195Sessler et al., "Tripyrroledimethine-derived (Texaphyrin-type) Macrocycles: Potential Photosensitizers Which Absorb in the Far-red Spectral Region", SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique, 1426:318-329, 1991.196 *Sessler et al., A Water Stable Gadolinium (III) Complex Derived from a New Pentadentate , Chem. Absts. , 111:720, abstract no. 125716e, Oct. 2, 1989.197 *Sessler et al., A Water Stable Gadolinium (III) Complex Derived from a New Pentadentate Expanded Porphyrin Ligand , Inorg. Chem. , 28:3390 3393, 1989.198 *Sessler et al., An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand , J. Am. Chem. Soc. , 110:5586 5588, 1988.199 *Sessler et al., Anion Binding: A New Direction in Porphyrin Related Research, Pure & Applied Chem. , 65(3):393 398, 1993.200 *Sessler et al., Binding of Pyridine and Benzimidazole to a Cadmium Expanded Porphyrin: Solution and X ray Structural Studies , Inorg. Chem. , 28:1333 1341, 1989.201 *Sessler et al., Expanded Porphyrins: The synthesis and Metal Binding Properties of Novel Tripyrrane Containing Macrocycles , J. Coord. Chem. , 18:99 104, 1988.202 *Sessler et al., Gadolinium (II) Texaphyrin: A Novel MRI Contrast Agent, Journal of the American Chemical Society , 115(22):10,368 10, 369, 1993.203 *Sessler et al., Photodynamic Inactivation of Enveloped Viruses Using Sapphyrin, 22 Electron Expanded Porphyrin: Possible Approaches to Prophylactic Blood Purification Protocols, SPIE Photodynamic Therapy: Mechanisms II. 1203:233 245, 1990.204 *Sessler et al., Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy, Abstracts of Papers , Part 1, 204th ACS National Meeting, Aug. 23 28, 1992, Washington, DC.205 *Sessler et al., Synthesis and Applications of Schiff Base Derived Expanded Porphyrins, Abstracts of Papers , Part 1, 204th ACS National Meeting, Aug. 23 28, 1992, Washington, DC.206 *Sessler et al., Synthesis and Binding Properties of Monomeric and Dimeric Guanine and Cytosine Amine Derivatives, J. Org. Chem. , 1992, 47:826 834.207 *Sessler et al., Synthesis and Crystal Structure of a Novel Tripyrrane Containing Porphyrinogen like Macrocycle , J. Org. Chem. , 52:4394 4397, 1987.208 *Sessler et al., Synthesis and Structural Characterization of Lanthanide (III) Texaphyrins, Inorganic Chemistry , 32(14):3175 3187, 1993.209 *Sessler et al., Texaphyrin : A Novel 22 Electron Aromatic Pentadentate Macrocyclic Ligand , ACS meeting, Los Angeles , Sep. 1988.210 *Sessler et al., Texaphyrins: Synthesis and Applications, Accounts of Chemical Research , 27(2):43 50, 1994.211 *Sessler et al., The Coordination Chemistry of Planar Pentadentate Porphyrin Like Ligands , Comm. Inorg. Chem. , 7:333 350, 1988.212 *Sessler et al., The Synthesis and Structure of a Novel 22 Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Prophyrin , Toronto ACS Meeting, Jun. 1988. USA.213 *Sessler et al., Tripyrroledimethine derived (Texaphyrin type) Macrocycles: Potential Photosensitizers Which Absorb in the Far red Spectral Region , SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique , 1426:318 329, 1991.214Sessler, Jonathan L., "Texas-Sized Molecule," Discovery, 13(1):44-49, 1993.215 *Sessler, Jonathan L., Texas Sized Molecule, Discovery , 13(1):44 49, 1993.216Shelton and Morrow, "Catalytic Transesterification and Hydrolysis of RNA by Zinc(II) Complexes," Inorganic Chemistry, 30:4295-4299, 1991.217Stern et al., "Hydrolysis of RNA by Transition-Metal Complexes," J. Am. Chem. Soc, 112:5357-5359, 1990.218Stinson, "Unusual Porphyrin Analog Promises Many Applications", Chemical and Engineering News, pp. 26-27, Aug. 8, 1988.219 *Stinson, Unusual Porphyrin Analog Promises Many Applications , Chemical and Engineering News , pp. 26 27, Aug. 8, 1988.220Strobel and Dervan, "Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA," Journal of the American Chemical Society, 111(18):7286-7287, 1989.221 *Strobel and Dervan, Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA, Journal of the American Chemical Society , 111(18):7286 7287, 1989.222Sumaoka et al., "Remarkably Fast Hydrolysis of 3',5'-=Cyclic Adenosine Monophosphate by Cerium(III) Hydroxide Cluster," J. Chem. Soc. Chem. Comm., 2 pages, 1992.223Tabushi et al., "Lipophilic Diammonium Cation Having a Rigid Structure Complementary to Pyrophosphate Dianions of Nucleotides. Selective Extraction and Transport of Nucleotides," J. Am. Chem. Soc., 1981, 103:6152-6157.224 *Tabushi et al., Lipophilic Diammonium Cation Having a Rigid Structure Complementary to Pyrophosphate Dianions of Nucleotides. Selective Extraction and Transport of Nucleotides, J. Am. Chem. Soc. , 1981, 103:6152 6157.225Takasugi et al., "Sequence-Specific Photo-Induced Cross-Linking of the Two Strands of Double-Helical DNA by a Psoralen Covalently Linked to a Triple Helix-Forming Oligonucleotide," Proc. Natl. Acad. Sci. USA, 88:5602-5606, 1991.226Teare and Wollenzien, "Specificity of Site Directed Psoralen Addition to RNA," Nucleic Acids Res., 17(9):3359-3372, 1989.227Thaller et al., "Potential Use of Radiolabelled Porphyrins for Tumor Scanning," Porphyrin Photosensitization, Kessel and Dougherty, Eds., Plenum Press, New York and London, Publisher, pp. 265-278, 1981.228 *Thaller et al., Potential Use of Radiolabelled Porphyrins for Tumor Scanning, Porphyrin Photosensitization , Kessel and Dougherty, Eds., Plenum Press, New York and London, Publisher, pp. 265 278, 1981.229To and Neiman, "The Potential For Effective Antisense Inhibition of Retroviral Replication Mediated by Retroviral Vectors," Gene Regulation: Biology of Antisense RNA and DNA, 261-271, 1992.230Tohda et al., "Liquid Membrane Electrode for Guanosine Nucleotides Using a Cytosine-Pendant Triamine Host as the Sensory Element," Analytical Chemistry, 1992, 64(8):960-964.231 *Tohda et al., Liquid Membrane Electrode for Guanosine Nucleotides Using a Cytosine Pendant Triamine Host as the Sensory Element, Analytical Chemistry , 1992, 64(8):960 964.232Tweedle et al., "Principles of Contrast-Enhanced MRI, in Magnetic Resonance Imaging," 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793-809.233 *Tweedle et al., Principles of Contrast Enhanced MRI, in Magnetic Resonance Imaging, 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793 809.234Vlassov et al., "Photoactivatable Porphyrin Oligonucleotide Derivatives for Sequence Specific Chemical Modification and Cleavage of DNA," Nucleosides & Nucleotides, 10(1-3):641-643, 1991.235 *Vlassov et al., Photoactivatable Porphyrin Oligonucleotide Derivatives for Sequence Specific Chemical Modification and Cleavage of DNA, Nucleosides & Nucleotides , 10(1 3):641 643, 1991.236Vogel et al., "2,7,12,17-Tetrapropylporphycene -Counterpart of Octaethylporphyrin in the Porphycene Series", Angew. Chem., Int. Ed. Engl., 26:928-931, 1987.237Vogel et al., "New Porphycene Ligands: Octaethyl-and Etioporphycene (OEPc and EtioPc)-Tetra-and Pentacoordinated Zinc Complexes of OEPc," Angew. Chem. Int. Ed. Engl., 32(11):1600-1604, 1993.238Vogel et al., "Porphycene -a Novel Porphin Isomer", Angew. Chem., Int. Ed. Engl., 25:257-259, 1986.239 *Vogel et al., 2,7,12,17 Tetrapropylporphycene Counterpart of Octaethylporphyrin in the Porphycene Series , Angew. Chem., Int. Ed. Engl. , 26:928 931, 1987.240 *Vogel et al., Porphycene a Novel Porphin Isomer , Angew. Chem., Int. Ed. Engl. , 25:257 259, 1986.241Wagener and Beyrich, "Radiosensitizer-Biochemie und Tumortherapeutische Erfahrungen," Pharmazie, 47:815-824, 1992.242Wang et al., "Pyrrole chemistry. XVII. Alkylation of the pyrrolyl ambident anion," Can. J. Chem., 55:4112-4116, 1977.243 *Wang et al., Pyrrole chemistry. XVII. Alkylation of the pyrrolyl ambident anion, Can. J. Chem. , 55:4112 4116, 1977.244Wessel et al., "Porphyrins with Aromatic 26π-Electron Systems," Agnew. Chem. Int. Ed. Eng., 32(8):1148-1151, 1993.245Young et al., "Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex. A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging," Investigative Radiology, 29(3):330-338, 1994.246 *Young et al., Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex. A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging, Investigative Radiology , 29(3):330 338, 1994.247Zuk et al., "Pharmacokinetic and Tissue Distribution Studies of the Photosensitizer bis(Di-Isobutyl Octadecysiloxy) Silicon 2,3-Naphthalocyanine (isoBosinc) in Normal and Tumor-Bearing Rats," Photochemistry and Photobiology, 59(1):66-72, 1994.248 *Zuk et al., Pharmacokinetic and Tissue Distribution Studies of the Photosensitizer bis(Di Isobutyl Octadecysiloxy) Silicon 2,3 Naphthalocyanine (isoBosinc) in Normal and Tumor Bearing Rats, Photochemistry and Photobiology , 59(1):66 72, 1994.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS5969111 *Feb 4, 1997Oct 19, 1999Board Of Regents, The University Of Texas SystemTexaphyrins substituted with imidazole are providedUS6069140 *Nov 14, 1997May 30, 2000The Board Of Regents University Of Texas SystemPharmaceutical compositions comprising texaphyrinsUS6638924Aug 28, 2001Oct 28, 2003Pharmacyclics, Inc.Metallotexaphyrin derivativesUS6723750Mar 15, 2002Apr 20, 2004Allergan, Inc.Photodynamic therapy for pre-melanomasUS6825186Oct 27, 2000Nov 30, 2004Pharmacyclics, Inc.Method and compositions for treating atheroma, tumors and other neoplastic tissueUS6984734Feb 26, 2003Jan 10, 2006Board Of Regents, The University Of Texas SystemCyclo[n]pyrroles and methods theretoUS7105703Jun 23, 2005Sep 12, 2006University Of Kentucky Research FoundationCleavage of phosphate ester bonds by use of novel group 13 chelate compoundsUS7109188Sep 23, 2004Sep 19, 2006Pharmacyclics, Inc.Methods and compositions for treating atheroma, tumors and other neoplastic tissueUS7112671Aug 28, 2001Sep 26, 2006Pharmacyclics, Inc.Non-symmetric tripyrranes in the synthesis of novel macrocyclesUS7449454Sep 10, 2003Nov 11, 2008Pharmacyclics, Inc.Metallotexaphyrin derivativesUS7547689Mar 24, 2006Jun 16, 2009Pharmacyclics, Inc.Methods and compositions for treating atheroma, tumors and other neoplastic tissuesUS7579338Aug 16, 2006Aug 25, 2009Pharmacyclics, Inc.Methods and compositions for treating atheroma, tumors and other neoplastic tissuesUS8133474Sep 14, 2007Mar 13, 2012Massachusetts Institute Of TechnologySensors for fluorescence and magnetic resonance imagingUS8410263Apr 2, 2013Pharmacyclics, Inc.High-purity texaphyrin metal complexesUS8940882Apr 18, 2007Jan 27, 2015Becton, Dickinson And CompanyMultiple fluorophore detector systemUS20030232800 *Aug 28, 2001Dec 18, 2003Mody Tarak DNon-symmetric tripyrranes in the synthesis of novel macrocyclesUS20040053399 *Jul 17, 2003Mar 18, 2004Rudolf GilmanshinMethods and compositions for analyzing polymers using chimeric tagsUS20050064388 *Sep 23, 2004Mar 24, 2005Sessler Jonathan L.Methods and compositions for treating atheroma, tumors and other neoplastic tissueUS20060178314 *Mar 24, 2006Aug 10, 2006Sessler Jonathan LMethods and compositions for treating atheroma, tumors and other neoplastic tissuesUS20060181579 *Feb 14, 2006Aug 17, 2006Brother Kogyo Kabushiki KaishaInkjet Recording ApparatusUS20070004699 *Aug 16, 2006Jan 4, 2007Pharmacyclics, Inc.Methods and compositions for treating atheroma, tumors and other neoplastic tissuesUS20080138292 *Sep 14, 2007Jun 12, 2008Massachusetts Institute Of TechnologySensors for fluorescence and magnetic resonance imagingUS20090036664 *Jul 31, 2007Feb 5, 2009Brian Jon PeterComplex oligonucleotide primer mixUS20110223592 *Apr 18, 2007Sep 15, 2011Collis Matthew PMultiple fluorophore detector system* Cited by examinerClassifications U.S. Classification204/157.15, 435/91.1, 204/157.68International ClassificationA61K31/70, A61K48/00, C07H21/02, A61K31/40, C07D487/22, C07H21/04, C12N15/09, A61P31/12, A61P35/00, A61K41/00, B01J31/18, C07H21/00, A61K49/00, A61K47/48, C12N15/113Cooperative ClassificationA61K41/0076, C07H21/00, C07D487/22, C12N2310/3511, A61K41/0042, A61K41/0038, C12N15/113, A61K47/48069, B01J2531/36, B01J31/1815, B01J2531/025, A61K49/0021, C12N2310/15, C12N2310/321European ClassificationC07H21/00, A61K41/00W, A61K41/00P, A61K41/00R, B01J31/18B2B, A61K47/48H4H4, A61K49/00P4F4C, C12N15/113, C07D487/22Legal EventsDateCodeEventDescriptionJun 2, 1995ASAssignmentOwner name: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS,Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SESSLER, JONATHAN L.;REEL/FRAME:007529/0194Effective date: 19950527Owner name: PHARMACYCLICS, INC., CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MAGDA, DARREN;REEL/FRAME:007529/0166Effective date: 19950601Jan 19, 1999CCCertificate of correctionJun 27, 2000CCCertificate of correctionFeb 22, 2002FPAYFee paymentYear of fee payment: 4Mar 12, 2002REMIMaintenance fee reminder mailedFeb 27, 2006FPAYFee paymentYear of fee payment: 8Mar 29, 2010REMIMaintenance fee reminder mailedAug 25, 2010LAPSLapse for failure to pay maintenance feesOct 12, 2010FPExpired due to failure to pay maintenance feeEffective date: 20100825RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services