Source: http://www.google.com/patents/US20040186431?dq=6,240,376
Timestamp: 2017-03-25 05:09:48
Document Index: 344001162

Matched Legal Cases: ['Application No. 201', 'Application No. 101', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1']

Patent US20040186431 - Administering apparatus comprising a dosing device - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsAn administering apparatus having a casing including a reservoir for a product to be administered, a piston which can be shifted in the reservoir in an advancing direction towards a reservoir outlet to administer the product, a piston rod, a dosing and drive element for performing a dosing movement for...http://www.google.com/patents/US20040186431?utm_source=gb-gplus-sharePatent US20040186431 - Administering apparatus comprising a dosing deviceAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20040186431 A1Publication typeApplicationApplication numberUS 10/767,972Publication dateSep 23, 2004Filing dateJan 29, 2004Priority dateJul 30, 2001Also published asCA2451884A1, CA2451884C, CN1538857A, CN100518841C, DE10163326A1, DE50209180D1, EP1414505A2, EP1414505B1, US8007476, WO2003011371A2, WO2003011371A3Publication number10767972, 767972, US 2004/0186431 A1, US 2004/186431 A1, US 20040186431 A1, US 20040186431A1, US 2004186431 A1, US 2004186431A1, US-A1-20040186431, US-A1-2004186431, US2004/0186431A1, US2004/186431A1, US20040186431 A1, US20040186431A1, US2004186431 A1, US2004186431A1InventorsRoney Graf, Fritz KirchhoferOriginal AssigneeRoney Graf, Fritz KirchhoferExport CitationBiBTeX, EndNote, RefManPatent Citations (31), Referenced by (68), Classifications (15), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetAdministering apparatus comprising a dosing device
US 20040186431 A1Abstract
An administering apparatus having a casing including a reservoir for a product to be administered, a piston which can be shifted in the reservoir in an advancing direction towards a reservoir outlet to administer the product, a piston rod, a dosing and drive element for performing a dosing movement for selecting a product dose and a delivery movement for delivering the product dose, and a dose setting member which is moved in the advancing direction during the delivery movement, and which engages the piston rod and the casing such that it can only be moved in the advancing direction jointly with the piston rod and is moved counter to the advancing direction relative to the piston rod during the dosing movement. Images(10) Claims(20)
1. An administering apparatus comprising a dosing device, said administering apparatus comprising: a) a casing comprising a reservoir for a product which can be delivered; b) a piston which can be shifted in the reservoir in an advancing direction towards a reservoir outlet to deliver the product; c) a piston rod; d) a dosing and drive element using which a dosing movement for selecting a product dosage and a delivery movement for delivering the product dosage can be performed relative to said casing, and which is in an engagement with said piston rod which slaves the piston rod during said dosing movement, but which allows a delivery movement of said dosing and drive element relative to the piston rod; e) and a dosage setting member which is moved in the advancing direction by the dosing and drive element during the delivery movement, and which engages with each of the piston rod and the casing, such that it can only be moved in the advancing direction jointly with the piston rod and is moved counter to the advancing direction, relative to the piston rod, by the dosing movement. 2. The administering apparatus as set forth in claim 1, wherein said dosage setting member and the dosing and drive element are arranged one behind the other, without overlapping, with respect to the advancing direction. 3. The administering apparatus as set forth in claim 1, wherein a blocking means is provided which engages with the piston rod in order to prevent the piston rod from moving counter to the advancing direction. 4. The administering apparatus as set forth in claim 1, wherein a blocking means is provided which is in a braking engagement with the piston rod which makes it more difficult for the piston rod to move in the advancing direction. 5. The administering apparatus as set forth in claim 3, wherein the piston rod and said blocking means engage such that the piston rod slaves the blocking means during the dosing movement. 6. The administering apparatus as set forth in claim 3, wherein the blocking means is coupled to the casing such that it can be rotated about a longitudinal axis of the piston rod. 7. The administering apparatus as set forth in claim 3, wherein the piston rod comprises at least one row of teeth with which at least one engagement element of the blocking means engages. 8. The administering apparatus as set forth in claim 1, wherein the casing forms a linear guide for the dosage setting member, with which the dosage setting member engages. 9. The administering apparatus as set forth in claim 8, wherein: the casing comprises at least a front casing section and a rear casing section which can be detachably connected to each other; said front casing section contains the reservoir and forms said linear guide for the dosage setting member; and said rear casing section comprises the dosing and drive element. 10. The administering apparatus as set forth in claim 1, wherein one of a cannula of at most 30 gauge or a cannula having a combination of outer and inner-diameter not specified in ISO 9626, having an outer diameter of 320 μm at most, forms an infusing part of the injection apparatus. 11. The administering apparatus as set forth in claim 10, wherein said cannula is one of a 31 or 32 gauge cannula. 12. A reservoir module for an administering apparatus as set forth in claim 1, said reservoir module comprising: a) a casing section of the administering apparatus, comprising a reservoir for a product which can be delivered and a connecting means for connecting to a rear casing section of the administering apparatus; b) a piston which is accommodated in said reservoir such that it can be shifted in an advancing direction towards a reservoir outlet, in order to deliver product; c) a piston rod which is mounted by the front casing section, such that it can be rotated about its longitudinal axis, and comprises a thread; and d) a dosage setting member which is in threaded engagement with the piston rod and is guided by the front casing section, such that a rotational movement of the piston rod about its longitudinal axis moves said dosage setting member counter to the advancing direction; e) wherein the piston rod comprises a connecting section for coupling to a dosing and drive element of the administering apparatus, and wherein said connecting section is formed such that the coupling between the piston rod and the dosing and drive element of the administering apparatus allows the dosing and drive element and the piston rod to shift relative to each other along the longitudinal axis of the piston rod and prevents the dosing and drive element and the piston rod from rotating relative to each other about the longitudinal axis of the piston rod. 13. The reservoir module as set forth in claim 12, wherein the front casing section comprises a sleeve-shaped reservoir part comprising the reservoir and a sleeve-shaped mechanism holder, which are either detachably or non-detachably connected to each other, wherein said mechanism holder holds the piston rod and guides the dosage setting member. 14. The reservoir module as set forth in claim 12, wherein said reservoir module is a disposable module provided to be exchanged in its entirety after the reservoir has been emptied. 15. The reservoir module as set forth in claim 12 which is provided as an exchange module for a reservoir module forming a part of an administering apparatus. 16. The reservoir module as set forth in claim 15, wherein said administering apparatus comprises: a) a casing; b) a piston which can be shifted in an advancing direction; c) a piston rod; d) a dosing and drive element using which a dosing movement for selecting a product dosage and a delivery movement for delivering the product dosage can be performed relative to said casing, and which is in an engagement with said piston rod which slaves the piston rod during said dosing movement, but which allows a delivery movement of said dosing and drive element relative to the piston rod; e) and a dosage setting member which is moved in the advancing direction by the dosing and drive element during the delivery movement, and which engages with each of the piston rod and the casing, such that it can only be moved in the advancing direction jointly with the piston rod and is moved counter to the advancing direction, relative to the piston rod, by the dosing movement 17. An administering apparatus comprising: a casing comprising a reservoir for containing a product to be administered; a piston which can be shifted in the reservoir in an advancing direction towards a reservoir outlet to administer the product; a piston rod; a dosing and drive element for selecting a product dose and for delivering the product dose, said dosing and drive element in an engagement with said piston rod which slaves the piston rod during said selecting and which allows a delivery movement of said dosing and drive element relative to the piston rod; and a dose setting member movable in the advancing direction by the dosing and drive element during said delivering, said dose setting member engaging the piston rod and the casing such that it moves in the advancing direction jointly with the piston rod and moves counter to the advancing direction and relative to the piston rod by said selecting. 18. The administering apparatus according to claim 17, wherein the dosing and drive element is connected, secured against rotating, to the piston rod, and the dose setting member engages with the casing to move the dose setting member counter to the advancing direction. 19. The administering apparatus according to claim 18, wherein the dosing and drive element pushes against the dose setting member during the delivery movement. 20. The administering apparatus according to claim 19, wherein the dosing and drive element and the dose setting member are arranged one behind the other, without overlap, with respect to the advancing direction.
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of International Application No. PCT/CH02/00410, filed on Jul. 22, 2002, which claims priority to German Application No. 201 12 501.3, filed on Jul. 30, 2001 and German Application No. 101 63 326.2, filed on Dec. 21, 2002, the contents of both of which are incorporated herein by reference in their entirety.
BACKGROUND [0002] The invention relates to administering apparatus and methods, including injection apparatus. Such administering apparatus include those provided for medical, therapeutic, diagnostic, pharmaceutical or cosmetic applications, among other uses. More particularly, the present invention relates to administering apparatus, such as injection apparatus and devices, which allow a dose to be selected. Examples include injection pens, in particular semi-disposable pens, however, an administering apparatus in accordance with the present invention may also take the form of an inhalation apparatus or an apparatus for dispensing a product to be ingested orally, in doses. [0003] Administering apparatus should generally be easy to handle and therefore small, yet should exhibit as high a degree of functionality, accuracy, ease of use as possible. So-called injection pens, which are referred to as such due to their slim shape, automatically fulfill the first aspect. One aspect with regard to functionality is the capacity to freely select the product dosage to be injected in an injection. The option of selecting the product dose is advantageous, including in those applications in which a user administers the product to be injected him/herself, as is common in diabetes therapy or administering hormones, to name but two exemplary applications. In known devices, the option of flexibly selecting the product dosage, however, involves a corresponding technical complexity which not only increases the price, but also enlarges the apparatus in question. [0004] An injection pen in which the product dosage may be selected is described in U.S. Pat. No. 4,973,318. The pen comprises a piston rod which is formed by a threaded rod and serves to shift a piston in a product ampoule and so deliver the product. The pen comprises a front casing sleeve and a rear casing sleeve which can be rotated relative to each other about a common longitudinal axis. The product dosage is selected by relatively rotating the two casing sleeves. The piston rod is in threaded engagement with a threaded nut. The threaded nut forms a front section of a sleeve-shaped dosing and activating element. This dosing and activating element protrudes into the rear casing sleeve at a rear end and is connected, secured against rotating, to the rear casing sleeve, but can be shifted back and forth relative to the rear casing sleeve in the longitudinal direction of the piston rod. If the rear casing sleeve is rotated for the purpose of selecting the dosage, then the dosing and activating element compulsorily rotates with it. Since, however, the piston rod is connected, secured against rotating, to the front casing sleeve, the rotational movement moves the dosing and activating element further backwards, out of the rear casing sleeve. This increases the overall length of the arrangement of the piston rod and the dosing and activating element, and increases a slight distance between the front end of the dosing and activating element and a stopper area of the casing. This slight distance corresponds to the maximum possible stroke when the dosing and activating element is advanced, together with the piston rod, towards a front end of the pen, for the purpose of delivering the product. Due to this very simple dosing mechanism, the stroke of the delivery movement corresponds to the respectively set product dosage and is thus variable. [0005] An injection pen is known from WO 97/17096 which always exhibits the same delivery stroke, irrespective of the selected product dosage. The piston rod is likewise formed as a threaded rod and connected, secured against rotating, to the casing of the pen. A dosage setting nut is in threaded engagement with the piston rod. The piston rod protrudes into a sleeve-shaped dosing and activating element. The dosing and activating element and the dosage setting nut of this pen are separate parts. The dosing and activating element is connected, secured against rotating, to the dosage setting nut, but can be shifted in the longitudinal direction of the piston rod. For this engagement, the dosing and activating element surrounds the dosage setting nut. For selecting the product dosage, the dosing and activating element is rotated about the longitudinal axis, wherein the dosage setting nut is rotated with it. Since the dosage setting nut is in threaded engagement with the piston rod, linearly guided on the casing, and since the piston rod is blocked against moving counter to the advancing direction, the dosage setting nut is moved backwards and therefore deeper into the dosing and activating element, during its rotational movement along the piston rod. A slight distance results between the front end of the dosage setting nut and a stopper of the casing lying opposite in the advancing direction, said slight distance corresponding to the path which the piston rod and the dosage setting nut can jointly travel during the delivery movement, and thus to the product dosage. To form the connection, secured against rotating, between the dosing and activating element and the dosage setting nut, it is necessary for these two parts to overlap along the longitudinal axis, which increases the diameter of the pen. When using the dosing mechanism in a semi-disposable injection pen, assembling the parts of such a pen is made more difficult if the dosage setting nut and the dosing and activating element are each components of parts of the pen which have to be connected to each other. SUMMARY [0006] It is an object of the invention to provide an administering apparatus wherein the product dosage or dose may be selected, and wherein the apparatus is slim, inexpensive and enables a constant delivery stroke. [0007] Another object is to provide a dosing mechanism for a semi-disposable injection pen or other administering apparatus such that assembling the apparatus when exchanging a reservoir module is simplified. [0008] In one embodiment, the present invention comprises an administering apparatus having a casing including a reservoir for a product to be administered, a piston which can be shifted in the reservoir in an advancing direction towards a reservoir outlet to administer the product, a piston rod, a dosing and drive element for performing a dosing movement for selecting a product dose and a delivery movement for delivering the product dose, and a dose setting member which is moved in the advancing direction during the delivery movement, and which engages the piston rod and the casing such that it can only be moved in the advancing direction jointly with the piston rod and is moved counter to the advancing direction relative to the piston rod during the dosing movement. [0009] In one embodiment, the present invention comprises an administering apparatus comprising a casing, a reservoir for a product which can be delivered, preferably injected, and a piston which is accommodated in the reservoir such that it can be shifted in an advancing direction towards a reservoir outlet, such that product is delivered through the reservoir outlet by shifting the piston in the advancing direction. The reservoir can be formed by a container which is accommodated by the casing. A suitable ampoule or the like can form the reservoir. In principle, however, the reservoir can also be formed directly by the casing itself, i.e., without interposing another product container. In some embodiments, the product is preferably a liquid for medical, therapeutic, diagnostic, pharmaceutical or cosmetic applications. Insulin, growth hormone, liquid or pulpy food are some examples. The administering apparatus may be employed in applications in which a user self-administers the product him/herself, for example as is common in diabetes therapy, but its use in the field of in-patients or out-patients, by doctors or trained staff, is not excluded. [0010] The administering apparatus further comprises a piston rod which serves to move the piston in the advancing direction. The piston rod can be connected fixedly, i.e., permanently, to the piston, by which forming the piston and the piston rod as one piece is also to be understood. In one preferred embodiment, however, the piston and the piston rod are embodied as separate components, and a front end of the piston rod pushes against a rear side of the piston for the purpose of delivering product. [0011] Furthermore, the administering apparatus comprises a dosing and drive element using which a dosing movement for selecting a product dosage and a delivery movement for delivering the product dosage can be performed relative to the casing. In some embodiments, the delivery movement is preferably in the advancing direction, and the dosing movement is preferably a rotational movement about an axis parallel to the advancing direction. The dosing and drive element is in an engagement with the piston rod which slaves the piston rod during the dosing movement, but which does not impede, or at least allows, a delivery movement of the dosing and drive element relative to the piston rod. In some embodiments, the engagement between the dosing and drive element and the piston rod is preferably a positive lock. If the dosing movement is a rotational movement, the engagement between the dosing and drive element and the piston rod creates a connection, secured against rotating about the rotational axis of the rotational movement. [0012] In some embodiments, the administering apparatus further comprises a dosage setting member which engages which each of the piston rod and the casing. Due to the engagement with the piston rod and the engagement with the casing, the dosage setting member can only be moved in the advancing direction jointly with the piston rod and is moved counter to the advancing direction, relative to the piston rod, by the dosing movement. The dosage setting member is moved in the advancing direction by the dosing and drive element during its delivery movement. It thus completes a delivery movement, jointly with the piston rod itself, which is transferred onto the piston and results in product delivery. [0013] In some embodiments, the engagement between the dosage setting member and the piston rod is preferably a threaded engagement. In this case, the piston rod is provided with a thread around the longitudinal axis of the piston rod. The engagement can also be formed differently, for example in the manner of a ratchet. Such a toothed engagement, however, is preferably used to prevent the piston from moving counter to the advancing direction. [0014] Since the dosing and drive element does not act directly on the piston rod during its delivery movement, but rather on the dosage setting member, as is already known in principle from WO 97/17096, a delivery stroke can be achieved which is always the same length. Since, however, unlike known injection apparatus, the dosing and drive element of the present invention is connected, secured against rotating, to the piston rod, and the dosage setting member engages with the casing in order to obtain a dosing stroke of the dosage setting member counter to the advancing direction, the administering apparatus of the present invention is slimmer. The dosing and drive element no longer has to encompass the dosage setting member, as is the case with the known apparatus, in order to perform the dosing stroke of the dosage setting nut. It is sufficient if a front abutting area of the dosing and drive element pushes against the dosage setting member in the course of its delivery movement in order to advance it together with the piston rod for delivery of a dose. Accordingly, the dosing and drive element and the dosage setting member can advantageously be arranged one behind the other, without overlapping, with respect to the advancing direction. [0015] The dosing and drive element can be a simply shaped part which, with respect to dosing, only has to be additionally shaped such that the shifting connection, secured against rotating, to the piston rod can be established. By omitting the engagement between the dosing and drive element and the dosage setting member for the purpose of dosing, it is necessary for the dosage setting member and the casing to engage, however this does not require an additional space transverse to the piston rod. The casing preferably forms a linear guide, pointing in the advancing direction, for the dosage setting member. [0016] Embodiments of the present invention are particularly advantageous in so-called semi-disposable administering apparatus, in particular semi-disposable injection pens. Such administering apparatus comprise a reservoir module which not only comprises the reservoir for the product, but also holds the piston rod. Once the reservoir has been emptied, the entire reservoir module including the piston rod is exchanged for a new reservoir module with a filled reservoir. A rear portion of such a semi-disposable administering apparatus comprises a dosing and drive element and usually a counting and indicating means. This portion of the administering apparatus, which is generally technically complex and therefore expensive, is designed as a reusable part and can be repeatedly connected to a new reservoir module. The reservoir module, by contrast, can be designed as a disposable part, hence the designation “semi-disposable.” In such apparatus, assembling the new reservoir module and the rear portion of the apparatus with the dosing and drive element is made easier by the present invention, since it is not necessary during assembly to establish an engagement between the dosing and drive element of the rear portion of the apparatus and the dosage setting member, which is a component of the reservoir module. [0017] A dosing and drive device in accordance with the present invention can operate manually, semi-automatically or fully automatically. In the first case, both the rotational dosing movement and the translational delivery movement are performed manually. In the second case, either the rotational dosing movement or the translational delivery movement is performed manually, and the other movement is performed using motors or by means of another type of force application, for example by means of a spring force, when the user has triggered the corresponding movement using an actuating handle, button, or other suitable actuator. In the third case, that of the fully automatic dosing and drive device, the dosing movement and the delivery movement are performed using motors or by means of another force, for example a spring force. In this case, only the dosage is selected manually, for example by means of one or more buttons, and the delivery movement is triggered by the user using an actuating feature. In some embodiments, an administering apparatus in accordance with the present invention is equipped with a manual dosing and drive device, which is then referred to as a dosing and activating device. Thus, whenever a dosing and activating device is mentioned, it is therefore the manual embodiment which is being referred to. Where a dosing and drive device is mentioned, this is not intended to restrict the invention with respect to being manual, semi-automatic or fully automatic, but rather to comprise each of these embodiments. The term “dosing and activating module” is, however, used in connection with all the embodiments of the dosing and drive device. [0018] The dosing and drive device can separately comprise a dosing element which performs the dosing movement and a drive element which performs the delivery movement. In some preferred embodiments, however, the dosing movement and the delivery movement are performed by the same body of the dosing and drive device which is therefore also referred to in the following descriptions as a dosing and drive element or dosing and activating element. [0019] In the case of an injection apparatus, the product can be administered by means of an injection cannula or a nozzle (in needle-free injections). The product can in particular be injected or infused subcutaneously or venously, or also intramuscularly. When administered by inhalation, the selected product dosage may be delivered from a reservoir into a chamber of the inhalation apparatus and vaporized for inhalation by means of a vaporizing means. Furthermore, oral ingestion is conceivable, or administering via the esophagus, to name but a few administering examples. [0020] In some embodiments, the administering apparatus of the present invention is preferably semi-disposable. In this case, the front casing section is a support for a reservoir module which is disposed of or recycled once the reservoir has been emptied, and the rear casing section is a support for a dosing and activating module which can be repeatedly used in conjunction with a new reservoir module. Since the reservoir module can also be treated separately as a disposable module, it is also a separate subject of the invention. The dosing and activating module can also be also a separate subject of the invention. Equally, a system consisting of an administering apparatus and at least one reservoir module, which can replace the reservoir module of the apparatus once it has been used, forms a subject of the invention. The duplex design of the administering apparatus, divided into a portion provided for use only once and a portion provided for repeated use (semi-disposable), is advantageous for injection pens in particular, but also for example for inhalation apparatus or apparatus for orally ingesting a product or for artificial feeding.
BRIEF DESCRIPTION OF THE DRAWINGS [0021] [0021]FIG. 1 depicts two portions of a reservoir module in accordance with a first exemplary embodiment; [0022] [0022]FIG. 2 depicts the reservoir module obtained from the two portions of FIG. 1; [0023] [0023]FIG. 3 depicts an injection apparatus comprising the reservoir module of FIG. 2, in accordance with the first exemplary embodiment, in a longitudinal section; [0024] [0024]FIG. 4 depicts a portion of the injection apparatus of FIG. 3; [0025] [0025]FIG. 5 depicts a mechanism holder of the reservoir module, in a longitudinal section and two views; [0026] [0026]FIG. 6 depicts a blocking means for a piston rod, mounted by the mechanism holder; [0027] [0027]FIG. 7 depicts a piston rod in a longitudinal section and a front view; [0028] [0028]FIG. 8 depicts a latching block in a longitudinal section, a view and a top view; [0029] [0029]FIG. 9 depicts a second exemplary embodiment of an injection apparatus; [0030] [0030]FIG. 10 depicts the cross-section A-A of FIG. 9; [0031] [0031]FIG. 11 depicts the cross-section B-B of FIG. 9; [0032] [0032]FIG. 12 depicts the cross-section C-C of FIG. 9; [0033] [0033]FIG. 13 depicts the cross-section D-D of FIG. 9; [0034] [0034]FIG. 14 depicts the mechanism holder of the second exemplary embodiment, in a perspective representation; [0035] [0035]FIG. 15 depicts the mechanism holder of FIG. 14; [0036] [0036]FIG. 16 depicts the cross-section A-A of FIG. 15; [0037] [0037]FIG. 17 depicts the dosage setting member of the second exemplary embodiment, in a perspective representation; [0038] [0038]FIG. 18 depicts the dosage setting member of FIG. 17 in a longitudinal section; [0039] [0039]FIG. 19 depicts the dosage setting member of FIG. 17; [0040] [0040]FIG. 20 depicts the dosage setting member of FIG. 17 in a top view; [0041] [0041]FIG. 21 depicts a portion of the injection apparatus in accordance with FIG. 3; and [0042] [0042]FIG. 22 depicts a portion of the injection apparatus in accordance with FIG. 9. DETAILED DESCRIPTION [0043] [0043]FIG. 1 shows a view of a reservoir part 1 and a mechanism holder 3, which are connected to each other to form the reservoir module 10 shown in FIG. 2. [0044] In FIGS. 1 and 2, a piston rod 4 can be seen which protrudes, on an end of the mechanism holder 3 facing away from the reservoir part 1, into the mechanism holder 3. The piston rod 4 is mounted by the mechanism holder 3 such that it can shift in an advancing direction pointing in the longitudinal axis L of the piston rod 4, towards a front end of the reservoir part 1 facing away from the mechanism holder 3. The reservoir part 1 is substantially a hollow cylinder which has a circular cross-section and comprises a connecting region at its front end for connecting to a needle holder for an injection needle. The reservoir part 1 serves to accommodate a reservoir container which in the exemplary embodiment is formed by an ampoule 2 which can be seen in the longitudinal section in FIG. 3. An outlet at the front end of the ampoule 2 is sealed fluid-tight by a membrane. When the needle holder is fastened to the front end of the reservoir part 1, a rear portion of the injection needle pierces the membrane, such that a fluid connection between the tip of the hollow injection needle and the reservoir 2 is established. [0045] [0045]FIG. 3 shows an embodiments of the injection apparatus in its entirety, in a longitudinal section. A piston is accommodated in the ampoule 2 such that it can shift in the advancing direction towards the outlet formed at the front end of the ampoule 2. Shifting the piston in the advancing direction displaces product out of the ampoule 2 and delivers it through the outlet and the injection needle. [0046] The piston is advanced by the piston rod 4 which pushes against the piston via its front end and thus moves the piston in the advancing direction when advanced itself. The piston rod 4 is held by the mechanism holder 3 such that it can be moved in the advancing direction once a certain resistance has been overcome, but not counter to the advancing direction. The piston rod 4 is prevented from moving backwards, counter to the advancing direction, by a blocking means 8. The blocking means 8 is axially fixed by the mechanism holder 3, i.e., it is held in the mechanism holder 3 such that it cannot be moved in and counter to the advancing direction. It is, however, mounted by the mechanism holder 3 such that it can be rotated about the longitudinal axis L. The blocking means 8 also generates the resistance which has to be overcome in order to move forwards. [0047] One exemplary blocking means 8 is shown on its own in FIG. 6. It is formed by a one-part annular element which, rotatable about the longitudinal axis L, abuts the mechanism holder 3 between two facing, spaced collars 3 b which protrude radially inwards from an inner surface of the mechanism holder 3. The collars 3 b form a fixing means for axially fixing the blocking means 8. How the blocking means 8 is mounted in the mechanism holder 3 is most clearly seen from the representation of the mechanism holder 3 in FIG. 5. [0048] A dosage setting member 9 is accommodated in the mechanism holder 3. The dosage setting member 9 is formed as a threaded nut and is in threaded engagement with an outer thread of the piston rod 4. The dosage setting member 9 is secured against rotating by the mechanism holder 3, but is guided such that it can move axially and linearly in and counter to the advancing direction. The piston rod 4 and the dosage setting member 9 form a spindle drive for selecting the product dosage to be administered. [0049] The ampoule holder 1 and the mechanism holder 3 are connected to each other, secured against rotating and shifting, and together form the reservoir module 10 of the injection apparatus. Thus, in some embodiments, the reservoir module 10 comprises the piston rod 4 held by the mechanism holder 3 by means of the blocking means 8, and the dosage setting member 9. The ampoule holder 1 and the mechanism holder 3 together form a front casing section 1′ of the injection apparatus. A rear casing section 11 is connected to the front casing section in a positive lock. The rear casing section 11 forms the support for a dosing and activating element 12 and, together with the dosing and activating element 12 and parts of a latching means and other parts, forms a dosing and activating module 30. [0050] Except for the dosage setting member 9, the piston rod 4 and the blocking means 8, a dosing and activating device comprises the other components for selecting the product dosage and activating the injection apparatus. In particular, it comprises the dosing and activating element 12. In some embodiments, the dosing and activating device further comprises a counting and indicating means 17 for counting and optically indicating the selected product dosage. The counting and indicating means 17 makes the dosing and activating module 30 a high-grade and therefore expensive part of the injection apparatus. While the comparatively inexpensive reservoir module 10 is designed as a disposable module, the dosing and activating module 30 is intended for repeated use, with new reservoir modules 10. [0051] For selecting the product dosage, i.e., for dosing, the dosing and activating element 12 can be rotated about the longitudinal axis L and is furthermore mounted by the rear casing section 11 such that it can linearly shift along the longitudinal axis L, in and counter to the advancing direction. The dosing and activating element 12 is hollow, cylindrical and surrounds the piston rod 4 via a front section. A rear section of the dosing and activating element 12 protrudes out beyond a rear end of the casing section 11. A rod-shaped dosing slaving means 13 is inserted into the dosing and activating element 12 from the rear, as far as a collar of the dosing and activating element 12 protruding radially inwards. Furthermore, at the rear end, a closure 14 is inserted into the dosing and activating element 12, as far as the dosing slaving means 13. The dosing slaving means 13 is axially fixed relative to the dosing and activating element 12 between the radially protruding collar of the dosing and activating element 12 and the closure 14. The dosing slaving means 13 is also connected, secured against rotating, to the dosing and activating element 12. For the purpose of dosing, the dosing slaving means 13 protrudes into the hollow piston rod 4 from the rear. The piston rod 4 comprises a connecting section 4 a (FIG. 4) which engages with the dosing slaving means 13 such that the piston rod 4 and the dosing slaving means 13 and therefore also the dosing and activating element 12 cannot be rotated relative to each other about the common longitudinal axis L, but can be moved relative to each other along the longitudinal axis L, in and counter to the advancing direction. For this purpose, the connecting section 4 a is formed as a linear guide for the dosing slaving means 13. [0052] A restoring means 16 elastically tenses the dosing and activating element 12 counter to the advancing direction, into the initial position shown in FIGS. 3 and 4. In the initial position, the product can be dosed by rotating the dosing and activating element 12 about the longitudinal axis L. Then, from the initial position, the selected product dosage can be delivered by axially shifting the dosing and activating element 12. The restoring means 16 is formed by a spiral spring acting as a pressure spring, which is accommodated in an annular gap around the dosing and activating element 12 and axially supported between a collar of the casing section 11 protruding radially inwards and a collar of the dosing and activating element 12 facing opposite and protruding radially outwards. [0053] The blocking means 8 fulfils a double function. On one hand, it ensures, via its blocking elements 8 a, that the piston rod 4 cannot be moved back, counter to the advancing direction, relative to the mechanism holder 3 and therefore in particular relative to the piston accommodated in the ampoule 2. In its double function as a brake, the blocking means 8 furthermore prevents the piston rod 4 from moving forwards during the dosing process in which the dosage setting member 9 is moved axially, counter to the advancing direction, towards the dosing and activating element 12. [0054] In the initial position shown in FIGS. 3 and 4, before dosing, the dosage setting member 9 abuts against a delivery stopper 3 c (FIG. 5) formed by the mechanism holder 3, in the advancing direction. The piston rod 4 is in permanent touching contact with the piston. For the purpose of dosing, the dosage setting member 9 is moved away from the delivery stopper 3 c towards the dosing and activating element 12 by the threaded engagement with the piston rod 4 and the linear guide from the mechanism holder 3. This reduces a slight distance between a rear stopper area of the dosage setting member 9 and a front stopper area of the dosing and activating element 12, but on the other hand increases the slight distance between a front stopper area of the dosage setting member 9 and the delivery stopper 3 c. The latter distance between the delivery stopper 3 c and the dosage setting member 9 is the path length by which the dosage setting member 9 and—due to the threaded engagement—also the piston rod 4 are moved in the advancing direction in the course of the delivery movement of the dosing and activating element 12. The delivery stopper 3 c forms a front translational stopper. During the delivery movement, the piston rod 4 pushes via its front end, which is formed by a plunger body connected to the piston rod 4 such that it cannot move in or counter to the advancing direction, against the piston and pushes the piston forwards in the advancing direction towards the outlet of the ampoule 2. The longitudinal axis L forms the rotational and translational axis of the movements which are performed for the purpose of dosing and delivering the product. [0055] The distance which the dosage setting member 9 and the dosing and activating element 12 exhibit between each other during the dosing process when the dosage setting member 9 abuts against the delivery stopper 3 c corresponds to the maximum product dosage which can be selected and delivered in the course of a delivery. The stroke movement of the dosing and activating element 12 is of equal length for each delivery. Dosing sets the distance between the dosage setting member 9 and the delivery stopper 3 c and therefore the path length which can be jointly traveled by the dosing and activating element 12 and the dosage setting member 9 in the course of delivery. [0056] The braking function of the blocking means 8 and the braking engagement which exists between the piston rod 4 and the blocking means 8 for this purpose are clear from an overview of FIGS. 6 and 7. On the one hand, the blocking means 8 comprises two braking elements 8 b for the braking engagement, which are each formed by an elastically flexing catch, like the blocking elements 8 a. In the exemplary embodiment, the blocking means 8 is formed by a single annular element from which four elastic catches axially project on an abutting side. The catches are arranged in a uniform distribution over the circumference of the annular element. Two mutually opposing catches form the blocking elements 8 a and the other two catches, likewise arranged mutually opposing, form the braking elements 8 b. [0057] The piston rod 4 accordingly comprises two returning blocking means 6, which are formed on the outer surface on opposing sides and extend in the longitudinal direction of the piston rod 4, and two advancing braking means 7, which likewise extend in the longitudinal direction of the piston rod 4 on mutually opposing sides. The thread of the piston rod 4 for the threaded engagement with the dosage setting member 9 is formed by four remaining threaded sections 5 which extend over almost the entire length of the piston rod 4. The returning blocking means 6 and the advancing braking means 7 are each formed by a row of teeth. However, while the teeth of the returning blocking means 6 are formed as serrated teeth, narrowing in the advancing direction and comprising blocking areas pointing backwards and extending transverse to the advancing direction, the two rows of teeth which form the advancing braking means 7 do not comprise blocking areas pointing forwards having a comparable blocking effect. The teeth of the advancing braking means 7 each exhibit a “softer” tooth profile as compared to the returning blocking means 6. For the braking engagement between the blocking means 8 and the advancing braking means 7 of the piston rod 4 is not intended to prevent the piston rod 4 from being advanced, but merely to make it more difficult, in order to ensure that the piston rod 4 is not moved in the advancing direction during dosing. The front sides of the teeth of the advancing braking means 7 and the rear sides of the braking elements 8 b, which touch the front sides of the teeth of the advancing braking means 7, are shaped such that a threshold force which is not reached during dosing has to be overcome in order to overcome the braking engagement. This threshold force is larger than the force required to move the teeth of the returning blocking means 6 over the blocking elements 8 a in the advancing direction. In some embodiments, the threshold force is preferably at least twice as large as the initial frictional force between the returning blocking means 6 and the blocking elements 8 a. The frictional force between the latter also only increases gradually between two consecutive blocking engagements in the course of the advancing movement. The threshold force of the braking engagement, by contrast, has to be applied from one blocking engagement to the next, immediately at the beginning of the advancing movement, in each blocking engagement. The threshold force should not, however, be so large that it distracts the user during delivery. [0058] An undesired advancing movement by the piston rod as a response to the movement by the dosage setting member 9 when selecting the dosage can in principle also be prevented by the blocking engagement of the blocking means 8 alone. However, such a movement is more reliably prevented because of the braking engagement than by the blocking engagement alone. [0059] The connection between the reservoir module 10 and the dosing and activating module 30 is a positive lock. A latching engagement exists between the mechanism holder 3 and the casing section 11 which prevents relative movement in the axial direction. Beyond the latching engagement, the front casing section 1, 3 and the rear casing section 11 are guided axially and linearly directly onto each other, in order to prevent relative rotating when connected or connected. The axial guides 3 d of the mechanism holder 3, which together with one or more corresponding engagement elements of the rear casing section 11 form the linear guide, can be clearly seen in FIG. 5. The axial guides 3 d are formed by guide areas on guide ribs; they could also be formed by guide areas in axially extending recesses. In this way, axial guide channels are obtained. The guide ribs are axially tapered, such that insertion funnels leading into the guide channels are formed for the one or more engagement elements of the rear casing section 11. In order to even better center the casing sections at the beginning of connecting, the guide ribs are also tapered in the radial direction. In some embodiments, the one or more engagement elements of the rear casing section 11 is or are preferably formed like the axial sections 3 d on the surface counter area, i.e., the inner surface area, of the rear casing section 11. [0060] The latching engagement exists between a first, female latching element 3 a of the mechanism holder 3 (FIG. 5) and a latching ring 20 which is connected to the rear casing section 11 such that it can move radially but not axially. The latching ring 20 forms a second, male latching element 21 which radially engages directly with the first latching element 3 a. A lock/latch connection exists between the first latching element 3 a and the second latching element 21 which prevents the reservoir module 10 and the dosing and activating module 30 from moving axially relative to each other. [0061] [0061]FIGS. 3 and 4 show the latching element 21 in latching engagement with the latching element 3 a. The latching element 3 a is formed by an annular stay and a groove which runs around the outer surface of the mechanism holder 3. The annular stay forms a rear side wall of the groove. The second latching element 21 is formed by a cam which protrudes radially inwards from the inner surface of the latching ring 20 and which in the latching engagement is pushed radially inwards over an inner surface area of the rear casing section 11, protruding into the accommodating latching element 3 a, by a restoring means 24. The latching ring 20 is supported in its entirety in the radial direction on an inner surface area formed by the rear casing section 11, by means of the restoring means 24, such that the restoring means 24 pushes against the outer surface of the latching ring 20 roughly in a radial extension of the latching element 21. The latching ring 20 surrounds the mechanism holder 3 and can be moved in its entirety radially back and forth against the restoring force of the restoring means 24, such that the second latching element 21 can be moved in and out of latching engagement with the first latching element 3 a. The rear casing section 11 forms a tight sliding guide for the radial movement of the latching ring 20. On its side radially opposite the latching element 21, the latching ring 20 forms an unlatching button 22 for the user. In order to radially guide the restoring means 24 formed as a pressure spring, a guide cam projects radially from the outer surface area of the latching ring 20 facing away from the latching element 21. [0062] Two blocking cams 23, which press radially outwards against a latching block 25, project from the outer surface area of the latching ring 20, in the circumferential direction on both sides of said guide cam and axially behind the guide cam. Since the blocking cams 23 abut against the latching block 25, a radial movement of the latching element 21—which could result in the latching engagement being released—is prevented. The latching engagement between the latching elements 3 a and 21 is thus secured by the latching block 25. The latching engagement is secured in every position of the dosing and activating element 12, except for a releasing position which the dosing and activating element 12 assumes at the end of its delivery movement. The releasing position therefore coincides with the foremost shifting position which the dosing and activating element 12 assumes when it abuts the dosage setting member 9 in the course of its delivery movement and the dosage setting member 9 for its part abuts against the delivery stopper 3 c of the mechanism holder 3. Providing the dosing and activating module 30 is not yet connected to the reservoir module, a mechanical stopper for the dosing and activating element 12 is formed by a stopper element 31 of the dosing and activating device. In the exemplary embodiment, a reset holder ring which serves to reset the indicator 17 forms the stopper element 31. The dosing and activating element 12 abutting against said stopper element 31 defines the releasing position of the dosing and activating element 12 in this case, the releasing position defined by the stopper element 31 corresponding to that defined by the dosage setting member 9 abutting the delivery stopper 3 c. [0063] [0063]FIG. 8 shows the latching block 25. In the exemplary embodiment, it is formed as one piece by a blocking slider. The latching block 25 comprises a plate-shaped main body which extends axially when assembled, as for example shown in FIG. 4. At one end, a stay 26 projects at right angles from the main body. When assembled, the stay 26 extends radially as far as the dosing and activating element 12. The stay 26 serves to fasten the latching block 25 to the dosing and activating element 12 which for this purpose comprises two annular stays formed axially spaced on an outer surface area, which form the slaving means 15 a and 15 b. The front slaving means 15 a simultaneously forms the support collar for the restoring means 16. In the annular space formed between the slaving means 15 a and 15 b, the latching block 25 protrudes in via its stay 26 and is tightly enclosed axially on both sides by the two slaving means 1Sa and 15 b. [0064] At a front end facing away from the stay 26, the main body of the latching block 25 is provided with an axial recess 27 which is open towards the front end of the latching block 25. In this way, blocking tongues 28 extending axially on both sides of the recess 27 are formed. The blocking cams 23 of the latching ring 20 are arranged such that each of said blocking cams 23 pushes against one of the blocking tongues 28, providing the dosing and activating element 12 does not assume the releasing position. When the latching block 25 moves axially, the restoring means 24 for the latching element 21 extends through the axial recess 27. Indentation recesses 29 are furthermore formed in the main body of the latching block 25, and define the releasing position of the dosing and activating element 12. One indentation recess 29 is provided for each of the blocking cams 23. The position of the indentation recesses 29 is selected such that they only overlap the blocking cams 23, and thus allow the blocking cams 23 to be inserted, when the dosing and activating element 12 has been advanced into its releasing position. [0065] It should be clear that in some embodiments, a single blocking cam 23 could also be provided and the latching block 25 accordingly would comprise only one indentation recess 29 and possibly also only one blocking tongue 28. Furthermore, the latching block could in principle be produced together with the dosing and activating element 12 as one piece. Forming it as a separate part, however, offers advantages with regard to production, assembly and the dosing and activating element 12 cooperating with the piston rod 4. With respect to the installation length of the latching block 25, it should also be pointed out that the latching block 25 is supported, on its outer side facing away from the latching element 21, on an inner surface area of the casing 11. In this way, the stability of securing the latching engagement is increased. The casing 11 preferably forms an axial guide for the latching block 25. [0066] The functionality or operation of an injection apparatus in accordance with the present invention is described in the following, wherein it is assumed that a new reservoir module 10 and a dosing and activating module 30 which has already been used at least once are assembled and a product is then delivered for the first time. [0067] The dosing and activating module 30 and the new reservoir module 10 are aligned axially with respect to each other, such that their two longitudinal axes are flush with each other. The reservoir module 10 is then inserted via its rear end into the casing 11, which is open to the front, of the dosing and activating module 30. This centers one casing section with the other on the tapered ends of the guide ribs 3 d of the mechanism holder 3. While being slid on, the two casing sections are guided axially and linearly onto each other in a rotational angular position pre-set by the linear guide, until the casing sections assume a connecting end position in which the latching engagement of the latching elements 3 a and 21 can be established or can be set by itself. [0068] The dosing and activating element 12 is locked in pre-set rotational angular positions relative to the rear casing section 11. The linear guide of the casing sections 1′ and 11 and the rotational angular locking positions of the dosing and activating element 12 are adjusted to each other such that the engagement, secured against rotating, between the dosing and activating element 12 and the piston rod 4 is established in every locking position of the dosing and activating element 12 and every rotational angular position in which the casing sections 1′ and 11 are linearly guided onto each other. [0069] If the dosing and activating element 12 is situated in an axial position relative to the casing section 11 which is behind the releasing position, the latching element 21 is held in its radially innermost position by the latching block 25. In this position of the latching element 21, the dosing and activating module 30 and the reservoir module 10 cannot be slid onto each other up to the connecting end position and therefore also cannot be connected to each other, since the annular stay formed on the outer surface of the mechanism holder 3, which forms a part of the first latching element 3 a, comes to rest abutting against the second latching element 21 first. [0070] The annular stay can be reduced to a short radial protrusion in the tangential direction, if it is ensured that the casing sections can only be assembled in the rotational angular position in which such a protrusion and the second latching element 21 come to rest in an axial flush. The annular stay or radial protrusion could also form the first latching element 3 a alone, since the a function of the first latching element 3 a is to allow the connection between the reservoir module 10 and the dosing and activating module 30 to be established only when the dosing and activating element 12 assumes its releasing position. If this condition is fulfilled, then the dosing and activating element 12 would ensure, when the connection between the reservoir module 10 and the dosing and activating module 30 is established, that the dosage setting member 9 is situated in its dosing zero position in which it abuts the delivery stopper 3 c of the mechanism holder 3. [0071] In order to fulfill the condition described above, the user pushes the dosing and activating element 12 axially forwards relative to the rear casing section 11 as far as the releasing position. In this relative position between the rear casing section 11 and the dosing and activating element 12, the blocking cams 23 can be moved into the indentation recesses 29 of the latching block 25. The user therefore not only pushes the dosing and activating element 12 at least as far as the releasing position, but simultaneously also pushes the second latching element 21 out of latching engagement by means of the unlatching button 22. The reservoir module 10 can then be moved axially over the annular stay of the first latching element 3 a and inserted further into the rear casing section 11. The user can let go of the unlatching button 22. As soon as the second latching element 21 overlaps the first latching element 3 a, it snaps into the accommodating latching element 3 a due to the force of the restoring means 24, such that the latching engagement is established. The reservoir module 10 and the dosing and activating module 30 are then connected to each other in a defined way with respect to the position of the dosage setting member 9 and the piston rod 4. If the dosage setting member 9 still exhibited a slight distance from the delivery stopper 3 c before the latching engagement is established, this distance is eliminated due to the action of the dosing and activating element 12, required to establish the connection. A resultant delivery of product can be accepted and even desired, for the purpose of priming the injection needle. In some embodiments, this preferably resets the counting and indicating means 17 to zero. [0072] In the defined initial state brought about in this way, the user can dose the product. The product is dosed by rotating the dosing and activating element 12 about the longitudinal axis L and relative to the casing section 11. Since the dosing slaving means 13 is connected to the dosing and activating element 12, secured against rotating, and for its part engages with the piston rod 4, secured against rotating, the dosing and activating element 12 slaves the piston rod 4 during its rotational dosing movement. Due to the threaded engagement between the piston rod 4 and the dosage setting member 9 and the linear guide of the dosage setting member 9 by the mechanism holder 3, the dosage setting member 9 performs an axial, translational dosing movement, pre-set by the thread pitch of the reciprocal threaded engagement, towards the dosing and activating element 12. The dosing and activating element 12 forms a rear translational stopper 12 c which limits the translational dosing movement of the dosage setting member 9 and thus defines the maximum delivery stroke which may be set. [0073] The counting and indicating means 17 counts the dosage units corresponding to the rotational angular position of the dosing and activating element 12 and indicates it optically. [0074] Once the desired product dosage has been selected, the dosing process is completed. The selected product dosage is delivered by means of the delivery movement, pointing in the advancing direction of the piston, of the dosing and activating element 12. In the course of its delivery movement, the dosing and activating element 12 abuts against the dosage setting member 9 and slaves it. When the dosage setting member 9 abuts against the delivery stopper 3 c of the mechanism holder 3 in the course of the delivery movement, the delivery movements of the dosing and activating element 12 and the delivery of product are completed. In some embodiments, after the user lets go of the dosing and activating element 12, it is preferably moved counter to the advancing direction, back into a new initial position for dosing and delivering the product again, by the restoring means 16. The counting and indicating means 17 is preferably coupled to the dosing and activating element 12 such that it has in the meantime been reset back to zero. It possibly possesses means for counting and indicating the total product amount already delivered and thus the residue product amount remaining in the ampoule 2. [0075] In order to detach the reservoir module 10 from the dosing and activating module 30, the dosing and activating element 12 is advanced as far as the releasing position, i.e., until it abuts against the dosage setting member 9. In this position, the user can release the latching engagement again by pushing onto the unlatching button 22, and separate the reservoir module 10 from the dosing and activating module 30. [0076] FIGS. 9 to 13 shows a longitudinal section and four cross-sections of a second exemplary embodiment of the present invention, in this instance an embodiment of an injection apparatus. The injection apparatus of the second exemplary embodiment is identical to that of the first embodiment with respect to the latch and latching block 25, such that reference is made in this regard to the description of the first embodiment. In particular, the latching block 25 of the second embodiment is substantially identical to that of the first embodiment with respect to all its functional details. The same applies to the latching elements 3 a and 21. [0077] The latching ring 20 and the position of the blocking cams 23 relative to the latching element 21 and relative to the latching block 25 in the initial state of the apparatus can be seen particularly clearly in the cross-sections of FIGS. 10, 11 and 12, to which reference is made in this regard, also as representative for the first embodiment. [0078] The injection apparatus of the second embodiment differs from the first embodiment in the engagement and the progression of movement of the components involved in dosing. Furthermore, the mechanism holder fulfils, in addition to the functions of the mechanism holder of the first embodiment, in particular the function of positioning the dosage setting member in discrete rotational angular positions which may be changed relative to the mechanism holder, for the purpose of dosing. The blocking means of the second embodiment, by contrast, is embodied more simply than that of the first embodiment. Primarily, only the differences as compared to the first embodiment will be described in the following, wherein for components which are identical in their basic function to the components of the same name in the first embodiment but differ in details, numbers in the thirties with the same end digit, or exactly the same reference numerals as in the first embodiment, as used. Where no statements are made regarding the second embodiment, the corresponding statements regarding the first embodiment shall apply. [0079] In the second embodiment, the dosing and activating element 32, which can be axially and linearly moved relative to the rear casing section 11 and rotated about the longitudinal axis L, is connected to the dosage setting member 39, secured against rotating. The dosing and activating element 32 and the dosage setting member 39 can be moved in and counter to the advancing direction, relative to each other and relative to casing sections 1, 3 and 11. The piston rod 4 is held by a mechanism holder 3, secured against rotating. In cooperation with blocking elements of the blocking means 38, formed on the mechanism holder 3 as one piece, the returning blocking means 6, which is functionally identical to the first embodiment, prevents the piston rod 4 from moving counter to the advancing direction, but allows it to move in the advancing direction. The blocking elements simultaneously form the returning block and the rotational block for the piston rod 4. Furthermore, as previously in the first embodiment, the dosing and activating element 32 forms a sliding guide for the piston rod 4. [0080] During dosing, the dosing and activating element 32 performs the same rotational dosing movement as the dosing and activating element 12 of the first embodiment. However, since the engagement is secured against rotating, the dosage setting member 39 is slaved during the rotational dosing movement. The threaded engagement between the piston rod 4 and the dosage setting member 39 is again comparable to that of the first embodiment, such that due to the rotational dosing movement and the threaded engagement with the piston rod 4, a stopper 39 c formed by the dosage setting member 39 is moved, in the course of dosing, counter to the advancing direction, towards a front end of the dosing and activating element 32. As opposed to the first embodiment, the dosage setting member 39 thus completes a rotational dosing movement and a translational dosing movement relative to the front casing section during dosing, while the piston rod 4 remains stationary. Once dosing has been completed, the delivery movement of the dosing and activating element 32 advances the piston rod 4 by the path length which corresponds to the slight distance between a stopper area of the dosage setting member 39 and the delivery stopper 3 c of the mechanism holder 3, set by the dosing. [0081] The translational dosing movement of the dosage setting member 39 is limited counter to the advancing direction by a rear translational stopper 11 c which is formed directly by the rear casing section 11 itself. In the second embodiment, too, the rotational and translational axis of the components involved in dosing and delivering the product forms the longitudinal axis L. [0082] As in the first embodiment, the front casing section 1′ forms a sliding guide for the dosage setting member 39. In order to form the sliding guide, an inner surface area of the mechanism holder 3 and an outer surface area of the dosage setting member 39 are in sliding contact with each other. The dosing and activating element 32 engages with an inner surface area of the dosage setting member 39, to form the connection, secured against rotating, between the dosage setting member 39 and the dosing and activating element 32. [0083] In the second embodiment, the piston rod 4 comprises no braking means of its own beyond the returning blocking means 6. Rather, the front sides of the serrated teeth of the returning blocking means 6 also form the braking means on their own. The piston rod 4 of the second embodiment can, however, be replaced by the piston rod 4 of the first embodiment. Accordingly, the mechanism holder 3 of the second embodiment would in this case also have to form at least one braking element, preferably both braking elements, of the first embodiment. [0084] FIGS. 14 to 16 show the mechanism holder 3 of the second embodiment in a perspective representation, a side view and in the cross-section A-A indicated in the side view. As in the first embodiment, the mechanism holder 3 is embodied as a one-part sleeve part, preferably as a plastic injection molded part. It comprises a bulge 3 e on the outer surface of a front sleeve section. The front sleeve section is plugged into the reservoir part 1 and locked non-detachably, at least for the user, to the reservoir part 1 by means of the bulge 3 e. [0085] The latching element 3 a is formed on a middle sleeve section of the mechanism holder 3, as in the first embodiment. [0086] A rear sleeve section, connected to the latching element 3 a, forms a plurality of axial guides 3 d on its outer circumference. The axial guides 3 d are formed by guide ribs which protrude radially on the outer circumference of the rear sleeve section. More precisely, the axial guide formed by the axially extending, straight side walls of said guide ribs, such that—as in the first embodiment—axial guiding channels are obtained. The guide ribs protrude out from the middle sleeve section like fingers, as far as the rear end of the mechanism holder 3, where they taper off axially. The axial guide 3 d serves to linearly guide the rear casing section 11 when the reservoir module 10 is connected to the dosing and activating module 30. As can be seen in FIG. 9 and most clearly in FIG. 11, engagement elements 11 d project radially inwards from the inner surface area of the rear casing section 11, corresponding in number and adapted in shape. One engagement element 11 d protrudes into each of the axial guides 3 d and is linearly guided by the axial guide 3 d when the front casing section 1′ and the rear casing section 11 are slid into each other in order to be connected. In this way, it is ensured that there is no relative rotating between the front casing section and the rear casing section when the engagement, secured against rotating, between the dosing and activating element 32 and the dosage setting member 39 is established in the course of connecting. [0087] Since the guide ribs taper off axially at their rear ends, and the guide channels are thus widened into insertion funnels, centering between the front casing section 1′ and the rear casing section 11, for the purpose of connecting, is made easier. The guide ribs also taper off at their ends radially with respect to the surface area of the mechanism holder 3, which makes centering the casing sections into a rotational angular position pre-set by the axial guide 3 d, relative to each other, even easier. [0088] Just as the front casing section 1′ and the rear casing section 11 are prevented from rotating relative to each other when sliding them into each other, the dosage setting member 39 is also fixed with respect to its rotational angular position relative to the front casing section, the dosage setting member 39 being detachably fixed in order to allow the rotational movement of the dosage setting member 39 necessary for dosing. In order therefore to enable the dosing movement of the dosage setting member 39 on the one hand, but to prevent an undesired dosing movement by establishing the connection between the front casing section and the rear casing section, the dosage setting member 39 is fixed by the mechanism holder 3 in discrete rotational angular positions, by means of a releasable locking connection. [0089] FIGS. 17 to 20 show individual representations of the dosage setting member 39. For forming the locking connection, a number of locking recesses 39 g are formed on the outer surface area of the dosage setting member 39, distributed in regular separation over the circumference. Each of the locking recesses 39 g is formed by a straight, axially extending furrow having a rounded contour running in its cross-section. [0090] The mechanism holder 3 is provided with two locking projections 3 g (FIGS. 15 and 16). The two locking projections 3 g project radially inwards from an inner surface area of the mechanism holder 3 in the rear sleeve section of the mechanism holder 3. They are arranged diametrically opposed to each other. The respective surface region of the mechanism holder 3, on which one of the locking projections 3 g is formed, forms a spring element 3 f which is elastically flexible in the radially direction. Due to the elastic flexibility and the rounded shape of the locking projections 3 g, in conjunction with the rounded profile of the locking recesses 39 g, the locking engagement between the locking projections 3 g and the opposing locking recesses 39 g may be released for selecting the dosage. On the other hand, the locking engagement is however designed such that the dosage setting member 39 is rotationally angularly fixed sufficiently stable that there cannot be any undesired dosing movement of the dosage setting member 39 when the front casing section 1′ and the rear casing section 11 are connected, when the rotational coupling between the dosing and activating element 32 and the dosage setting member 39 is established. The locking connection between the mechanism holder 3 and the dosage setting member 39 has the advantageous side effect of a tactile signal during dosing. In order to maintain the favorable elasticity of the spring element 3 f, the rear sleeve section of the mechanism holder 3 is cut away in the surface region in question, such that the spring element 3 f is maintained as an annular segment extending in the circumferential direction which is axially free on both sides. [0091] Axial guides 39 d for the engagement, secured against rotating, between the dosage setting member 39 and the dosing and activating element 32 may likewise be seen in FIGS. 17, 18 and 20. The dosing and activating element 32 is provided with at least one engagement element, in order to obtain the axial linear guide, i.e., the rotational block, between the dosing and activating element 32 and the dosage setting member 39. The axial guides 39 d are again guide channels formed by a number of guide ribs extending axially in a straight line. Each of the guide ribs tapers off axially and radially at its rear end facing the dosing and activating element 32, in order to make centering between the dosing and activating element 32 and the dosage setting member 39 easier, when the engagement, secured against rotating, is established. The same design is therefore used for the axial linear guide of the dosage setting member 39 and the dosing and activating element 32 as for the axial linear guide of the casing sections 1, 3 and 11. [0092] For the sake of completeness, reference is lastly also made to the dosing thread 39 a and the delivery stopper 39 c of the dosage setting member 39, which can most clearly be seen in FIG. 18. [0093] Two rotational blocks are provided for the dosage setting member 39 which are active in the two axial end positions of the dosage setting member 39. Reference is additionally made in this regard to FIG. 22. [0094] In order to prevent the possibility of the piston rod 4 being moved back in response to a rotational dosing movement by the dosage setting member 39, rotational stoppers 39 h are formed at a front end of the dosage setting member 39. In the front position, which the dosage setting member 39 assumes directly after the product is delivered or before the dosage is selected, the rotational stoppers 39 h engage with rotational counter stoppers 3 h formed on the mechanism holder 3 (FIG. 16). The rotational stoppers 39 h axially project from a front abutting side of the dosage setting member 39, and the rotational counter stoppers 3 h protrude from an axially facing abutting area of the mechanism holder 3 forming the delivery stopper 3 c, axially opposed to the rotational stoppers 39 h. The engagement between the rotational stoppers 39 h and the rotational counter stoppers 3 h is such that it allows a rotational dosing movement in a rotational direction, which causes a translational dosing movement of the dosage setting member 39 directed away from the delivery stopper 3 c, but prevents a rotational dosing movement in the opposite rotational direction, in the front axial end position. [0095] Another pair of rotational stoppers and rotational counter stoppers is provided, which are formed and cooperate in basically the same way as the stoppers 3 h and 39 h. Said second pair of rotational stoppers are rotational stoppers 39 i on the one hand, which axially project from a rear abutting area of the dosage setting member 39, and rotational counter stoppers 11 i on the other, which axially protrude from the facing stopper abutting area of the rear translational stopper 11 c towards the dosage setting member 39, which however cannot be seen in FIG. 9 due to their small dimensions. In the rear end position, the rear pair of rotational stoppers 11 i/39 i prevents the possibility of the piston rod 4 being moved in the advancing direction in response to a dosing movement by the dosage setting member 39, directed against the rear translational stopper 11 c. [0096] The height, i.e., the axial length, of all the rotational stoppers 3 h, 39 h, 11 i and 39 i is adjusted to the thread pitch of the engaged dosing thread of the piston rod 4 and the dosage setting member 39. The rotational stoppers are axially sufficiently short that the rotational dosing movement which moves the dosage setting member 39 away from the respective translational stopper 3 c or 11 c is not impeded. [0097] When assembling the components of the reservoir module 10, the dosage setting member 39 is screwed onto the piston rod 4 as far as a pre-set axial position, as may be seen from FIG. 9. The piston rod 4, together with the screwed-on dosage setting member 39, is then inserted into the mechanism holder 3 from behind, until its blocking means 38 comes into blocking engagement with the returning blocking means 6 of the piston rod 4 and furthermore the engagement, secured against rotating, between the rotational stoppers 39 h of the dosage setting member 39 and rotational counter stoppers of the mechanism holder 3 is established. Even while being inserted into the mechanism holder 3, the dosage setting member 39 is axially and linearly guided by the mechanism holder 3 via the locking engagement between the locking projections 3 g and the locking recesses 39 g, until the dosage setting member 39 abuts the delivery stopper 3 c of the mechanism holder 3. In this front end position of the dosage setting member 39 relative to the mechanism holder 3, the engagement, secured against rotating, between the rotational stoppers 3 h and 39 h has also already been established. [0098] In this state, the mechanism holder 3 and a reservoir part 1, already fitted with a reservoir, are connected to each other. [0099] In a following step, the rear casing section 11 of the completely assembled dosing and activating module 30 is slid onto the mechanism holder 3, wherein the mechanism holder 3 and the rear casing section 11 can be centered with respect to each other due to the axial guides 3 d and the engagement elements 11 d of the rear casing section 11 and, once centered, are axially and linearly guided onto each other due to the guide engagement. In the course of sliding the rear casing section 11 onto the mechanism holder 3, the dosing and activating element 32 comes into engagement, secured against rotating, with the dosage setting member 39, wherein here too a certain centering is also possible first, using a linear guide corresponding to the axial guides 3 d and the engagement elements 11 d. [0100] The dosing and activating element 32 is in locking engagement with the rear casing section in discrete rotational angular locking positions and in the locking engagement, i.e., in the respective rotational angular locking position, is axially and linearly guided. The rotational angular difference between two consecutive rotational angular locking positions corresponds to one dosage unit. The linear guide between the mechanism holder 3 and the rear casing section 11 on the one hand, and the discrete rotational angular positions of the dosage setting member 39 relative to the mechanism holder 3 (locking projections 3 g and locking recesses 39 g) and the rotational angular locking positions of the dosing and activating element 32 relative to the rear casing section 11 on the other, are adjusted to each other such that the two casing sections 1, 3 and 11 are always slid linearly over each other in a rotational angular position such that the dosage setting member 39 and the dosing and activating element 32 are also aligned relative to each other for their engagement, secured against rotating, such that there is no relative rotating between the components involved in dosing while the reservoir module 10 is connected to the dosing and activating module 30. [0101] With respect to the other details of assembling, in particular of establishing the latching engagement, and of the functionality of the injection apparatus in accordance with the second embodiment, reference is made to the description of first embodiment. [0102] Rotational blocks can also be provided in the injection apparatus in accordance with the first embodiment, which prevent undesired response movements by the piston rod 4 in the two axial end positions of the dosage setting member 9 of the first embodiment. FIG. 21 shows the two rotational blocks, which are formed in the same way as the rotational blocks of the second embodiment. However, the rotational counter stoppers which in the second embodiment are formed on the casing sections 1′ and 11 are formed in the first embodiment by the blocking means 8 on the one hand and the dosing and activating element 12 on the other. Thus, a number of rotational stoppers 8 h are formed on the abutting side of the blocking means 8 axially facing the dosage setting member 9 and axially protrude towards the dosage setting member 9. Since the blocking means 8 is axially and immovably mounted by the front casing section 1′ and connected, secured against rotating, to the piston rod 4, a rotational block for the rotational dosing movement between the piston rod 4 and the dosage setting member 9 is also obtained, via the front pair of rotational stoppers 8 h/9 h. The second pair of rotational stoppers is formed between the dosage setting member 9 and the rear translational stopper 12 c. As in the second exemplary embodiment, a number of rotational stoppers 12 i protrude axially towards the dosage setting member 9 from the abutting area of the translational stopper 12 c axially facing the dosage setting member 9. As in the second embodiment, the dosage setting member 9 is provided on its rear side with rotational stoppers 9 i which in the rear axial end position of the dosage setting member 9 engage with the rotational stoppers 12 i. In the rear axial end position of the dosage setting member 9, the rear pair of rotational stoppers 9 i/12 i only allows the rotational dosing movement which causes a translational dosing movement of the dosage setting member 9 in the advancing direction. [0103] In the foregoing description, exemplary embodiments of the present invention, including preferred embodiments, have been presented for the purpose of illustration and description. They are not intended to be exhaustive or to limit the invention to the precise form disclosed. Obvious modifications or variations are possible in light of the above teachings. 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Lundbeck A/SLiquid formulations of salts of 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine* Cited by examinerClassifications U.S. Classification604/124International ClassificationA61M5/315, A61M5/20, A61M5/24, A61M5/30, A61M5/145, A61M5/00Cooperative ClassificationA61M5/31501, A61M5/315, A61M5/3158, A61M5/31553, A61M5/14566, A61M5/24, A61M5/31535European ClassificationA61M5/315E2B1BLegal EventsDateCodeEventDescriptionJan 29, 2004ASAssignmentOwner name: TECPHARMA LICENSING AG, SWITZERLANDFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GRAF, RONEY;KIRCHHOFER, FRITZ;REEL/FRAME:014946/0483Effective date: 20030912Jun 19, 2012CCCertificate of correctionApr 10, 2015REMIMaintenance fee reminder mailedAug 30, 2015LAPSLapse for failure to pay maintenance feesOct 20, 2015FPExpired due to failure to pay maintenance feeEffective date: 20150830RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services