Source: http://www.google.com/patents/US4345602?dq=5166694
Timestamp: 2014-03-07 08:43:25
Document Index: 200288354

Matched Legal Cases: ['art 6', 'art 2', 'art 3', 'art 4', 'art 6', 'art 6', 'art 6', 'art 0', 'art 0', 'art 0', 'art 0', 'art 30', 'art 0', 'art 0', 'art 30', 'art 0', 'art 0', 'art 30', 'art 0', 'art 0', 'art 30', 'art 0', 'art 0', 'art 30']

Patent US4345602 - Medical vascular guide wire and self-guilding type catheter - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsDisclosed is a medical vascular guide wire made of a synthetic resin hollow monofilament. The guide wire is comprised of a tip part, a flexible part having a smaller diameter than the other parts, a tapering part and a manipulating part, these four parts continuously forming in line, in that order, along...http://www.google.com/patents/US4345602?utm_source=gb-gplus-sharePatent US4345602 - Medical vascular guide wire and self-guilding type catheterAdvanced Patent SearchPublication numberUS4345602 APublication typeGrantApplication numberUS 06/116,600Publication dateAug 24, 1982Filing dateJan 29, 1980Priority dateFeb 8, 1979Also published asCA1153264A1, DE3061460D1, EP0014424A1, EP0014424B1Publication number06116600, 116600, US 4345602 A, US 4345602A, US-A-4345602, US4345602 A, US4345602AInventorsHiroaki Kudo, Hironori Yamada, Ryusaku Yamada, Kunio Yamada, Hidenaga YoshimuraOriginal AssigneeOsaka City Government, Toray Monofilament Company LimitedExport CitationBiBTeX, EndNote, RefManPatent Citations (5), Non-Patent Citations (5), Referenced by (103), Classifications (12) External Links: USPTO, USPTO Assignment, EspacenetMedical vascular guide wire and self-guilding type catheterUS 4345602 AAbstract Disclosed is a medical vascular guide wire made of a synthetic resin hollow monofilament. The guide wire is comprised of a tip part, a flexible part having a smaller diameter than the other parts, a tapering part and a manipulating part, these four parts continuously forming in line, in that order, along the monofilament axis. At least the tip part and the manipulating part have X-ray impermeable material inserted in the respective hollows thereof. A self-guiding type catheter made of a synthetic resin, multi-hollow monofilament is also provided. The catheter is comprised of a tip part, a flexible part having a smaller diameter than the other parts, a tapering part and a manipulating part, these four parts continuously formed in line, in that order, along the monofilament axis: The catheter has at least two hollows extending at least from one end of the manipulating part to the tapering part or to the other end of the manipulating part or to a point in close proximity to said other end of the manipulating part. At least one of the hollows has an X-ray impermeable material inserted at least within the hollow in the manipulating part, and the other hollow or at least one of the other hollows form a lumen for permitting a liquid and/or a gas to pass therethrough.
What we claim is: 1. A medical vascular guide insertable into a blood vessel for travel along the interior thereof; comprising(a) an elongated tubular outer member having(i) a manipulating part of first cross-sectional area; (ii) a flexible part, of reduced cross-sectional area relative to said manipulating part; (iii) a tapering part, connecting said manipulating part and said flexible part; (b) an elongated metal member occupying the interior of said manipulating part of said tubular member; (c) a tip member at an end of said flexible part remote from said tapering part, of integral unitary construction with said tubular member, of enlarged cross-sectional area relative to said flexible part; (d) a second metal member occupying the interior of said tip portion; (e) wherein said manipulating, tapering and flexible parts and said tip member are integrally formed of a single synthetic resin monofilament. 2. A medical vascular guide according to claim 1, wherein said elongated metal member has an end portion which is tapered and extends from said manipulating part into said tapered part, such that said tapered end of said metal member is directed toward said tip part of said guide.
DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to FIGS. 1A and 1B, the guide wire 1 is comprised of a tip part 6, a relatively flexible part 2 (which is hereinafter referred to as "flexible part" for brevity), a tapering part 3 and a manipulating part 4. These four parts continuously form in line, in that order, along the monofilament axis. The tip part 6 is of a hollow structure and has X-ray impermeable material 5 inserted therein. The shape of the tip part 6 is not particularly limited but may preferably be spherical, oval spherical or end-rounded cylindrical. The size of the tip part 6 is preferably about 0.5-3 mm, more preferably about 0.7-2 mm, in maximum diameter, and preferably about 0.5-5 mm, more preferably about 0.7-4 mm, in length.
(i) Silicon coating treatment A hollow monofilament body is passed several times through a bath of a solution of a medical silicone disolved in, for example, isopropanol, and then, the so coated monofilament body is dried under reduced pressure, thereby removing the solvent therefrom. Prior to the silicone coating treatment, the monofilament body may be surface-treated with sandpaper in order to facilitate the silicone coating treatment.
(ii) Fluorine-containing resin coating treatment A hollow monofilament body is treated with a solution of a fluorine-containing resin, such as "Teflon 30 J" (trade name, an aqueous suspension containing about 60 weight % of finely divided polytetrafluoroethylene having a particle size of about 0.3 micron, supplied by Mitsui Fluorochemical Co.) and "Teflon D-1" (trade name, an aqueous suspension of finely divided polytetrafluoroethylene, supplied by Daikin Kogyo K.K.). The treating procedure may be similar to that explained above with regard to the silicone coating treatment.
(iii) Plasma spark discharge treatment A hollow monofilament body is placed in a chamber which is maintained at a reduced pressure of below about 1 mmHg and into which a small amount of a gaseous organic fluorocompound is introduced. Then, a plasma spark discharge is effected, thereby introducing fluorine substituents into the polymer forming the surface of the monofilament.
EXAMPLE 1 Polyethylene terephthalate was melt-extruded in a conventional manner, by using an extruder provided with a spinneret having an annular orifice to obtain an undrawn hollow monofilament having an overall diameter of 0.7 mm and a hollow diameter of 0.35 mm. A tungsten piece of wire, 0.25 mm in diameter and 0.6 mm in length, was inserted in one end portion of the hollow monofilament, which portion had a length of 0.7 mm. Then, the open end was heat-sealed to form a tip part of a guide wire. Thereafter, the portion adjacent to the tip part was drawn to form a flexible part 0.3 mm in diameter and 3 cm in length and a tapering part 0.3-0.7 mm in diameter and 4 cm in length. A tungsten wire having a diameter of 0.3 mm was inserted into a manipulating part 0.7 mm in diameter and 1,500 mm in length, and then, its open end was heat-sealed to thereby obtain a monofilament guide wire.
EXAMPLE 2 Polyethylene terephthalate was melt-extruded in a conventional manner by using an extruder provided with a spinneret having an annular orifice to obtain a hollow monofilament having an overall diameter of 0.8 mm and a hollow diameter of 0.33 mm. The monofilament was cut into lengths of 1.3 m. A portion of each monofilament, which portion was adjacent to one end portion of the monofilament, was drawn about three times its original length to simultaneously form a flexible part 0.3 mm in diameter and 20 mm in length and a tapering part 30 cm in length. Then, a tungsten piece having a diameter of 0.3 mm and a length of 1.5 mm was inserted in the undrawn end portion, and then, its open end was heat-sealed, to thereby form an oval spherical tip part 0.8 mm in diameter and 2.5 mm in length. Thereafter, a tungsten wire having a tapered end portion and having a diameter of 0.25 mm and a length of 1.25 m was inserted in the other undrawn portion from the open end thereof, so that the tapered tip of the tungsten wire reached a midway point of the tapering part, and then, the open end was heat-sealed, whereby a synthetic resin monofilament guide wire was obtained.
EXAMPLE 3 A hollow monofilament having an overall diameter of 0.8 mm and a hollow diameter of 0.33 mm was prepared, in a manner similar to that mentioned in Example 2, from a molten mixture comprised of 95 weight % of polyethylene terephthalate and 5 weight % of a polytetrafuoroethylene resin "TLP-10" (trade name, supplied by Mitsui Fluorochemical Co.). The monofilament was cut into lengths of 1.3 m. A portion of each monofilament, which portion was adjacent to one end portion of the monofilament, was drawn about three times its original length to simultaneously form a flexible part 0.3 mm in diameter and 50 mm in length and a tapering part 30 mm in length. Then, a tungsten piece 0.3 mm in diameter and 1.5 mm in length was inserted in the undrawn end portion, and then, its open end was heat-sealed, to thereby form an oval spherical tip part 0.8 mm in diameter and 2.5 mm in length. Thereafter, a tungsten wire having a tapered end portion and having a diameter of 0.25 mm and a length of 1.25 m was inserted in the other undrawn portion from the open end thereof, so that the tapered tip of the tungsten wire reached a midway point of the tapering part, and then, the open end was heat-sealed, whereby a monofilament guide wire was obtained.
EXAMPLE 4 A hollow polyethylene terephthalate monofilament having a diameter of 0.8 mm and a hollow diameter of 0.33 mm was prepared in a manner similar to that mentioned in Example 2. The continuous monofilament was cut into lengths of 1.3 m. One portion of each monofilament, which portion was adjacent to one end portion of the monofilament, was drawn about three times its original length, to thereby simultaneously form a flexible part 0.3 mm in diameter and 50 mm in length and a tapering part 30 mm in length. Then, a tungsten piece 0.3 mm diameter and 1.5 mm in length was inserted in the undrawn end portion, and then, its open end was heat-sealed, to thereby form an oval spherical tip part 0.8 mm in diameter and 2.5 mm in length. Thereafter, a tungsten wire having a tapered end portion and having a diameter of 0.25 mm and a length of 1.25 m was inserted into each monifilament from the end thereof opposite to the tip part, so that the tapered tip of the tungsten wire was directed toward the tip part and reached a midway point in the tapering part, and then, the open end was heat-sealed, to thereby obtain monofilament guide wires.
(1) Silicone coating treatment A 2 weight % solution of "MDX4-4159" (trade name, room temperature drying type silicone lubricant, supplied by Dow Corning Co.) in isopropanol was prepared. The guide wire was immersed in the silicone solution. After being withdrawn from the silicone solution the guide wire was wiped by a gauge to remove the excessive amount of the silicone solution, and then, dried under reduced pressure. The so treated guide wire is referred to as "guide wire A" for brevity.
(2) Fluorine-containing resin coating treatment The guide wire was immersed in "Teflon 30 J" (trade name, an aqueous suspension containing 60 weight % of polytetrafluoroethylene having a particle size of about 0.3 micron, supplied by Mitsu Fluorochemical Co.). After being withdrawn from the suspension, the guide wire was dried under reduced pressure. The so treated guide wire is referred to as "guiding wire B" for brevity.
EXAMPLE 5 A hollow monofilament having a diameter of 0.8 mm and a hollow diameter of 0.33 mm was prepared in a manner similar to that mentioned in Example 2, from a tetrafluoroethylene/hexafluoropropylene copolymer "Teflon" FEP resin (supplied by Mitsu Fluorochemical Co.). The continuous monofilament was cut into lengths of 1.3 m. One portion of each monofilament, which portion was adjacent to one end portion of the monofilament, was drawn about three times its original length, to thereby simultaneously form a flexible part 0.3 mm in diameter and 25 mm in length and a tapering part 30 mm in length. Then, a tungsten piece 0.3 mm in diameter and 1.5 mm in length was inserted in the undrawn end portion, and then, its open end was heat-sealed, to thereby form an oval, spherical tip part 0.8 mm in diameter and 2.5 mm in length. Thereafter, a tungsten wire having a tapered end portion and having a diameter of 0.25 mm and a length of 1.25 m was inserted into the monofilament from the end thereof opposite to the tip part, so that the tapered tip of the tungsten wire was directed toward the tip part and reached a midway point in the tapering part, and then, the open end was heat-sealed, to thereby obtain a monofilament guide wire.
EXAMPLE 6 Polyethylene terephthalate was melt-extruded in a conventional manner by using an extruder provided with a spinneret having a special orifice, to thereby obtain a multi-hollow monofilament having an overall diameter of 1 mm and having two continuously extending hollows, each 0.33 mm in diameter. The multi-hollow monofilament was cut into lengths of 1.5 m. One portion of each monofilament, which portion was adjacent to one end portion (about 1 mm in length) of the monofilament, was drawn about three times its original length, to thereby simultaneously form a flexible part 0.3 mm in diameter and 50 mm in length and a tapering part 30 mm in length. Then, two tungsten pieces, each 0.3 mm in diameter and 0.5 mm in length, were inserted into the two hollows, respectively, in the undrawn end portion of about 1 mm in length, and then, the open ends were heat-sealed. Thereafter, a tungsten wire having a tapered end portion and having a diameter of 0.25 mm was inserted into one of the two hollows extending form the end of the manipulating part to the end of the tapering part, so that the tapered tip of the tungsten wire was directed to the tip part and reached a point in close proximity to the end of the tapering part, and then, the open end of the hollow in which the tungsten wire was inserted was heat-sealed. A small opening having a diameter of 0.25 mm was drilled in the wall of the tapering part of the other hollow, to thereby form a medicament outlet opening through which the other hollow was opened into the outside.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is an enlarged longitudinal sectional view illustrating one example of the guide wire of the invention;
SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a medical vascular guide wire, which has a smooth surface on which thrombi are deposited only to a slight extent, which is sufficiently flexible for permitting it to reach peripheral blood vessels in the affected parts without undue strain to the patient or taking a great deal of time, which is capable of being easily manipulated and which does not injure the intimae of blood vessels.
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