Source: https://patents.google.com/patent/CZ295757B6/en
Timestamp: 2020-02-19 16:47:16
Document Index: 348873175

Matched Legal Cases: ['art 1', 'art 2', 'art 1', 'art 1', 'art 1', 'art 2']

CZ295757B6 - Mechanical counter for a metering apparatus and inhaler of metered doses - Google Patents
Mechanical counter for a metering apparatus and inhaler of metered doses Download PDF
CZ295757B6
CZ295757B6 CZ19982049A CZ204998A CZ295757B6 CZ 295757 B6 CZ295757 B6 CZ 295757B6 CZ 19982049 A CZ19982049 A CZ 19982049A CZ 204998 A CZ204998 A CZ 204998A CZ 295757 B6 CZ295757 B6 CZ 295757B6
CZ19982049A
CZ204998A3 (en
1998-11-11 Publication of CZ204998A3 publication Critical patent/CZ204998A3/en
2005-10-12 Publication of CZ295757B6 publication Critical patent/CZ295757B6/en
229940071648 Metered Dose Inhaler Drugs 0 abstract claims description 21
In the present invention, there is described a mechanical counter for a metering apparatus having two coaxially arranged housing portions (1, 2), which are rotated relative to each other when the metering apparatus is operated wherein the mechanical counter further comprises at least one rotary spindle (4) with a screw thread thereon, the axis of which extends substantially parallel to the axis of the metering apparatus and which is mounted in the vicinity of ends of the spindle (4) with respective rotary mountings (5, 6) on the first housing portion (1), further tooth arrangement disposed at the spindle(4) end being nearest to the housing second portion (2), a cursor movable along the spindle (4) by the screw thread when the spindle (4) rotates, and a scale (27) disposed adjacent to the cursor. At an edge of the second housing portion (2), there is at least one projection (19, 20) for engaging the tooth arrangement on the spindle (4) to rotate the spindle (4) wherein said cursor is adjustable. There is also described a metered dose inhaler being provided with the above-described mechanical counter.
The present invention relates to a mechanical counter for a dispensing apparatus having two coaxially arranged housing portions that are rotated relative to each other when the dispensing apparatus is actuated, the counter comprising at least one rotatable spindle on which a screw thread whose axis extends in substantially parallel to the axis of the dispensing apparatus and which is disposed in the region of the peripheral surface of the dispensing apparatus and which is mounted at the ends of the spindle by corresponding rotatable bearings on the first housing part, a tooth arrangement at the end of the spindle closest to the second housing part; along the spindle by means of a screw thread when the spindle is rotating, and a scale located at the slider. The invention also relates to a metered dose inhaler comprising a nozzle assembly, an energy storage means, a reservoir, a valve arrangement, and having two coaxially arranged housing portions that rotate relative to each other when the dispensing apparatus is actuated.
It is an object of the present invention to provide an optimal adaptation of a counter of this type for handling the dispensing apparatus in a functionally reliable manner, and to simplify the manufacture of the counter.
The present invention has been developed particularly, but of course not exclusively, for use in metered dose inhalers (MDIs) as described, for example, in U.S. Patent No. 5,497,944 (derived from WO 91/14468), the entire contents of both publications being incorporated herein by reference. of this description by reference. Pressure (generally at least 50 bar (about 5 MPa)) is generated in a measured amount of fluid that is dispensed through a nozzle assembly having one or more very small orifices, for example in the range of 25 to 500 square micrometers. Preferred nozzle assemblies are described in U.S. Pat. No. 5,472,143 (and in parallel WO 94/07607), the entire contents of both of which are hereby incorporated by reference. The energy storage means, such as a spring, is preferably manually loaded, for example by means of a rotary saw tooth arrangement as described in U.S. Pat. No. 4,260,082 and GB patent application 2291135, the entire contents of both of which are hereby incorporated by reference. to this description by reference. The latch mechanism is generally designed to hold the spring in a stretched position and is manually releasable to pressurize a measured amount of fluid, for example, using a piston-cylinder arrangement. The reservoir and valve arrangement may be adapted to refill the cylinder. Further details are described in PCT / EP96 / 04351 and in parallel USSN 08/726219, the entire contents of both being incorporated herein by reference.
Dispensing devices are used, for example, in medical aerosol therapy for treating respiratory-tract diseases. In such a situation, the liquid or powdered medicament is sprayed to generate an aerosol, by means of a sprayer, or is added to the gas stream. The medicament is contained in a supply container that is inserted into the dispensing apparatus. The supply in the container may be sufficient for several days to several months. It is therefore necessary to display the amount of drug consumed or the amount of drug still present in the container.
PCT Patent Application WO-93/24167 discloses an imaging device for a medical dispensing apparatus. The display device comprises a ring which is rotatable in alignment with the apparatus and which, for each dose of medicament and under pressure that is withdrawn from the dosing apparatus, is automatically rotated by a predetermined angle by a wedge drive, with a small portion of this visible. ring. This display device is pneumatically actuated when the medicament is inhaled.
-1 CZ 295757 B6
U.S. Pat. No. 4,817,822 discloses a display device for a dispensing apparatus, the display apparatus comprising a linear or rotatable disk scale that is disposed adjacent the dispensing apparatus and which is displaced by the lock wheel and the locking pawl. Only a small part of this scale is visible through the window.
PCT patent publication WO-86/05991 discloses a display device for a dispensing apparatus, the apparatus comprising a disk scale with teeth at the periphery of the disk and being rotated by a worm element. Only a small part of this scale is visible through the window.
PCT patent publication WO-92/09324 discloses a display device for a dispensing apparatus in which the axial displacement of the storage container within the housing is transmitted by a locking pawl and a worm gear on a rotary scale, a small portion of which is visible through the window.
According to PCT publication WO-86/02275, the imaging device for a medical spray device comprises a digital mechanical counter that is driven by moving the storage container within the housing once the dose of substance is withdrawn from the storage container. This device includes a large number of individual components.
The display device, which is actuated pneumatically or mechanically when the pressurized storage container is moved in the housing of the dispensing apparatus, is unsuitable for a dispensing apparatus having two housing parts rotatable relative to each other and a storage container which is positioned firmly in the dosing device.
Accordingly, various methods have been sought to provide a suitable mechanical counter for a dispensing apparatus having two housing parts rotatable relative to each other.
According to the present invention there is therefore provided a mechanical counter for a dispensing apparatus having two coaxially arranged housing portions that are rotated relative to each other when the dispensing apparatus is actuated, the counter comprising at least one rotatable spindle on which the screw thread has an axis extending substantially parallel to the axis of the dispensing apparatus and located in the region of the peripheral surface of the dispensing apparatus and mounted at the ends of the spindle via corresponding pivot bearings on the first housing part, a tooth arrangement at the end of the spindle closest to the second housing part; a slider movable along the spindle by means of a worm thread when the spindle is rotating, and a scale located at the slider. The invention is characterized in that at the edge of the second housing part there is at least one projection for engaging the tooth arrangement on the spindle for rotating the spindle, the slider being adjustable.
A mechanical counter according to a preferred embodiment of the invention has two rotary bearings.
Preferably, each pivot bearing is in the form of a snap fit.
Preferably, at one end of the spindle which is at the second housing part and which forms the tooth arrangement, the mechanical counter according to the invention has pinion, and at the periphery of the second housing part has protrusions that engage the pinion at .
Preferably, the pinion has four teeth, and on the other part of the housing there are two projections.
-2GB 295757 B6
Preferably, the pinion has four teeth, of which two opposing teeth are wider than the other two teeth, the sides of the wider teeth abut against the inner peripheral surface of the second housing part, the second housing part has two protrusions, and there is an opening between the two protrusions. is greater than the width of the wider teeth on the pinion.
In a preferred embodiment of the mechanical counter according to the present invention its transmission ratio is half the spindle speed to the two starts of the dosing apparatus.
Preferably, the pitch of the screw thread on the spindle corresponds to the number of dispensing parts and the travel path of the slider.
Preferably, the slider on the spindle has a rotatable locking means.
Preferably, the spindle has means for preventing unwanted displacement.
Preferably, the means for preventing unwanted displacement is in the form of an active locking tooth arrangement.
The mechanical counter according to the invention preferably has at least one flexible wing with a worm-threaded engagement portion on the slider, the worm-threaded engagement portion engaging the worm-thread on the spindle.
The mechanical counter of this embodiment preferably has a recess at the other end of the spindle for receiving the engagement portion with the screw thread.
The mechanical counter according to the invention preferably has at least one adjusting projection on the carriage.
In a preferred embodiment of the invention, the slider comprises a display ring, at least one wing having an engagement portion with a screw thread, and at least one other wing with an adjusting projection.
The mechanical counter of the invention preferably has a housing over the first housing part, the housing being releasably connected to the first housing part in an axial direction and covering the spindle, and wherein the housing is transparent in the slider area or comprises a transparent material.
Preferably, in this embodiment, there is at least one pulling means on the inside of the housing.
The slider wings are preferably flexible.
In a preferred embodiment of the invention, a gear is provided at the other end of the spindle, and an annular gear with a means for preventing unwanted displacement, preferably with a flange with which said gear engages, is mounted coaxially rotatable relative to the first housing part.
The mechanical counter of this embodiment preferably has at least one first mark on the annular gear flange, which mark, after less than 360 degrees rotation of the annular gear relative to the first housing portion, is positioned against a second mark in a fixed position relative to the first housing parts.
The mechanical counter according to this embodiment preferably has a second mark on the first housing part or has a window in the housing on the first housing part.
Preferably, the mechanical counter of the invention further comprises a second spindle with unintended displacement means arranged in a substantially parallel relationship to the first spindle and a further slider with a rotary lock on the second spindle, and a one-gear transmission.
A gear assembly comprising a protruding pawl at one end of the first spindle, and a gear at a corresponding end of the second spindle into which said protruding pawl engages at the end of the first spindle, and a scale located at the slider on the second spindle.
In this embodiment of the mechanical counter, the slider is preferably not movable.
The mechanical counter of the invention preferably further comprises a roller coupled to the rotating spindle through the arrangement of the gear wheels for rotation therewith, the roller having a helical line extending therethrough along its length, the surfaces on the two sides of the helical line being differently labeled, and a narrow transparent strip in the cover through which you can see them! strip on the peripheral surface of the roller.
Preferably, in this embodiment, said surfaces are marked with different colors on two sides of the spiral line.
The mechanical counter of the preceding embodiments preferably further comprises a scale next to the transparent strip.
Preferably, the mechanical counter of the invention further comprises a second spindle with an inadvertent displacement means which is arranged in a substantially parallel relationship to the first spindle, and a further slider with a pivot lock on the second spindle, and a one-gear transmission system including a tooth arrangement at one end. a second spindle closest to the second housing part; and protrusions at the edge of the second housing part which engage a toothed arrangement at the end of the second spindle when the two housing parts rotate relative to each other.
The components of the counter may consist essentially of any material. These components are preferably made of a plastic material, for example, by an injection molding process. Physiologically harmless materials such as polybutylene terephthalate (PBT) or a compound of PBT and teflon (polytetrafluoroethylene) are used for medical purposes. These materials are preferably selected so that the different materials run against each other, for example, PBT with teflon against PBT or PBT against acrylic butadiene styrene.
The counter of the present invention may be used, for example, in a dispensing apparatus that serves as a high pressure atomizer for a liquid medicament. The liquid to be sprayed is placed in an unpressurized storage container which is connected to a miniaturized high pressure generating means by which aerosol is generated, details of which can be found in German Patent Application Laid-Open (DE-OS) 195 36 902.5 (the entire contents of this patent application is hereby incorporated by reference). The high pressure generating device is actuated by a spring-actuated locking compression mechanism, the spring being compressed by rotating the two housing parts relative to each other, details of these devices can be found in German Patent Application Laid-Open (DE-OS) 195 45 226.7 (the entire contents of this patent application is hereby incorporated by reference into this description). The counter of the present invention is automatically moved when the housing portions are rotated relative to each other.
According to the present invention there is also provided a metered dose inhaler comprising a nozzle assembly, an energy storage means, a reservoir, a valve arrangement, and having two coaxially arranged housing portions that rotate relative to each other when the dispensing apparatus is actuated. SUMMARY OF THE INVENTION The inhaler has a mechanical counter comprising a screw threaded spindle mounted in a bearing means on a first housing part in its peripheral region so as to be rotated by displacement of the second housing part, and an adjustable slider displaceable by the worm thread. to
The arrangement is such that displacement of the slider relative to the scale means provides a measure of the number of operations of the apparatus.
Preferably, the slider comprises an imaging ring, at least one wing having an engagement portion with a screw thread, and at least one other wing with an adjusting projection.
Preferably, the slider is releasable from the screw thread for adjustment.
The metered dose inhaler according to the invention preferably comprises means for indicating the number of times the slider has been moved over its displacement path.
In a metered dose inhaler according to the invention, preferably the spindle axis is substantially parallel to the axis of rotation of the housing parts, the spindle having a toothed wheel that cooperates with the means on the second housing part for rotating the spindle.
Preferably, half of the spindle revolution corresponds to a 360 ° rotational displacement of the two housing parts relative to each other.
Preferably, the spindle is rotated periodically, the rotation being associated with the actuation of the metered dose inhaler and this actuation being defined by the relative rotation of the two housing parts.
Preferably, the spindle is rotated with each actuation of the metered-dose inhaler, said actuation being defined by relative rotation of the two housing parts.
Preferably, the spindle has a rotatable locking means.
Preferably, the rotatable locking means is in the form of a latch.
A preferred embodiment of the present invention will now be described in more detail in the following description with reference to the accompanying drawing.
Overview of the figure in the drawing
Giant. 1 illustrates a portion of a dispensing apparatus having a counter according to the present invention, wherein in the illustrated embodiment the first housing portion is rotated 180 degrees relative to the second housing portion to actuate the dispensing apparatus.
The first housing part 1 is mounted coaxially rotatable with respect to the second housing part 2. The cover 3a, which is mounted on the first housing part 1, closes the first housing part 1 and the counter. This cover 3a is also shown by broken lines in the extended position 3b. The number of metering parts taken from the storage container that is in use is calculated over time by a spindle (rotating shaft) 4. This spindle 4 is rotatably mounted on the first housing part 1 by means of two snap-fit bearings 5 and 6 acting as bearings. The groove 7 which receives the bearing 5 serves to axially fix the spindle 4. The slide ring 9 is provided with two flexible wings 10, each having a corresponding worm threaded engagement portion 11 and two adjusting lugs 12 on the two wings 13. The recess 8 is a free displacement means for the engagement portion 11 at the end of its path. Two pulling means 14 are provided on the inside of the cover 3a, which, when the cover 3a is put in place, pushes the slider ring 9 back into
When this happens, the slider ring 9 pushes the slider against the stop 15 and the slider is released as described above.
At one end of the spindle 4 is located a four-toothed pinion 16 having two (in axial direction) narrow teeth 17 and two (in axial direction) wide teeth 18. The edge of the second housing part 2 carries two projections 19 and 20 between which As described above, the teeth 17, 18 and the protrusions 19, 20 preferably have an involute shape. At the other end of the spindle 4 is located a gear 22 which engages an annular gear 23. On the flange 24 of this annular gear 23 a plurality of numbered marks 25 are formed, of which the corresponding mark 25 always appears in the window 26 in the housing 3a. given by the rotational displacement of the annular gear 23.
The position of the slider ring 9 against the metering means in the form of a marked scale 27 shows the number of dispensing portions removed from the storage container or the number of dispensing portions that can still be removed from the storage container. When the storage container is empty, the corresponding one of the numbered marks 25 appears in the window 26.
The illustrated counter includes some of the preferred features of the present invention discussed above, and the entire description of the preferred embodiment herein should be read in conjunction with the foregoing description of these preferred features.
A preferred embodiment of the counter of the present invention has the following advantages:
the counter is automatically moved when the dosing device is started;
the counter is not a critical element in terms of tolerance and is therefore reliable and reliable in operation;
the transmission may be designed to cover a wide range;
the counter shows the number of dispensing portions dispensed and / or the number of dispensing portions still available, quasi-continuously and with a corresponding degree of accuracy;
the counter is inaccessible and cannot be offset by error when using a dosing device;
the counter may be sequentially used for a plurality of storage containers;
the counter may be made for a different number of dispensing parts from each storage container and for a different maximum number of storage containers that can be used with the dispensing apparatus;
the counter is integrated into the dosing device and does not require any substantial modification;
the counter can be manufactured in miniaturized form and thus takes up only a small amount of space;
the individual parts of the counter are preferably made of a plastic material that operates without lubricants at a low friction level;
no substance can reach the substance to be dosed from the counter;
the counter comprises a small number of individual components that can be cheaply manufactured by injection molding;
-6E 295757 B6 the counter is easy to assemble;
the counter may be adjusted each time the storage container is emptied, the initial position of the slider on the spindle being clearly set at any time when a fresh storage container is inserted;
the combination of a spindle that counts the triggering of the dispenser during use of the storage container with the second spindle or with the annular gear means that the dispenser can be reliably used for a predetermined total number of dispensing parts or for a predetermined total number of sequentially used storage containers. The period of use of the dosing device can be reliably checked.
A mechanical counter for a dispensing apparatus having two coaxially arranged housing portions (1, 2) that rotate relative to each other when the dispensing apparatus is actuated, the counter comprising at least one rotatable spindle (4) on which the screw is screwed a thread, the axis of which extends substantially parallel to the axis of the dispensing apparatus, and which is located in the region of the peripheral surface of the dispensing apparatus, and which is mounted at the ends of the spindle (4) by corresponding pivot bearings (5, 6) , a tooth arrangement at the end of the spindle (4) that is closest to the second housing part (2), a slider movable along the spindle (4) by a worm thread when the spindle (4) rotates, and a scale (27) located at a slider, characterized in that at the edge of the second housing part (2) there is at least one projection (19, 20) for engaging a toothed m by an arrangement on the spindle (4) for rotating the spindle (4), the slider being adjustable.
Mechanical counter according to claim 1, characterized in that it has two rotary bearings (5, 6).
Mechanical counter according to claim 2, characterized in that each pivot bearing (5, 6) is in the form of a snap fit.
Mechanical counter according to claims 1, 2 or 3, characterized in that at one end of the spindle (4), which is adjacent to the second housing part (2) and which forms a tooth arrangement, has a pinion (16), and the circumference of the second housing part (2) has protrusions (19, 20) that engage the pinion (16) on the rotationally displaceable portion of the two housing parts (1, 2) relative to each other.
Mechanical counter according to claim 4, characterized in that the pinion (16) has four teeth (17, 18), and on the second housing part (2) there are two projections (19, 20).
Mechanical counter according to claim 4, characterized in that the pinion (16) has four teeth (17, 18) of which two opposing teeth (18) are wider than the other two teeth (17), the sides of the wider teeth (18) bear against the inner peripheral surface of the second housing part (2), there are two projections (19, 20) on the second housing part (2), and there is an opening (21) between the two projections (19, 20) which is greater than the width of the wider teeth (18) on the pinion (16).
Mechanical counter according to any one of claims 1 to 6, characterized in that its transmission ratio is half the speed of the spindle (4) to two starts of the dosing apparatus.
-7EN 295757 B6
Mechanical counter according to any one of claims 1 to 7, characterized in that the pitch of the screw thread on the spindle (4) corresponds to the number of dispensing parts and the travel path of the slider.
Mechanical counter according to any one of the preceding claims, characterized in that the slider has a rotary locking means on the spindle (4).
Mechanical counter according to any one of claims 1 to 9, characterized in that the spindle (4) has means for preventing unwanted displacement.
Mechanical counter according to any one of claims 1 to 10, characterized in that the means for preventing unwanted displacement is in the form of an active locking tooth arrangement.
Mechanical counter according to any one of claims 1 to 11, characterized in that it has at least one flexible wing (10) on the slider with an engagement portion (11) with a screw thread, the engagement portion (11) with the screw thread engaging in screw and spindle (4).
Mechanical counter according to claim 12, characterized in that at the other end of the spindle (4) it has a recess (8) for receiving the engagement portion (11) with the screw thread.
A mechanical counter according to any one of claims 1 to 13, characterized in that it has at least one adjusting projection (12) on the slider.
A mechanical counter according to any one of the preceding claims, characterized in that the slider comprises a display ring (9), at least one wing (10) having an engagement portion (11) with a screw thread, and at least one other wing (13). the adjusting lug (12).
Mechanical counter according to any one of claims 1 to 15, characterized in that a cover (3a) is disposed over the first housing part (1), the housing (3a) being releasably connected to the first housing part (1) in an axial manner and the cover is transparent in the region of the slider or comprises transparent material.
Mechanical counter according to claim 16, characterized in that at least one pulling means (14) is provided on the inside of the housing (3a).
Mechanical counter according to claims 15, 16 or 17, characterized in that the slider wings (10, 13) are flexible.
Mechanical counter according to any one of claims 1 to 18, characterized in that a gear (22) is provided at the other end of the spindle (4) and an annular gear (23) is mounted coaxially with respect to the first housing part (1). with means for preventing inadvertent displacement, preferably with a flange (24) with which said gear (22) engages.
A mechanical counter according to claim 19, characterized in that it has at least one first mark (25) on the annular gear flange (24), the mark being, after less than 360 degrees rotation of the annular gear (23). with respect to the first housing part (1), placed against a second mark which is in a fixed position relative to the first housing part (1).
Mechanical counter according to claim 20, characterized in that it has a second mark on the first housing part (1) or has a window (26) in the housing (3a) on the first housing part (1).
-8EN 295757 B6
A mechanical counter according to any one of claims 1 to 21, further comprising a second spindle with a means for preventing unwanted displacement, which is arranged in a substantially parallel relationship to the first spindle (4), and a further slider with rotary lock on a second spindle, and a single-tooth transmission system comprising a protruding pawl at one end of the first spindle (4), and a gear at a corresponding end of the second spindle into which said protruding pawl at the end of the first spindle (4) and a scale that is located at the rider on the second spindle.
23. The mechanical counter of claim 22, wherein the slider is not movable.
A mechanical counter according to any one of claims 1 to 23, further comprising a roller coupled to the rotating spindle by arranging the gear wheels for rotation therewith, the roller having a spiral line therewith guided with rotation over its entire length, wherein the surfaces on the two sides of this spiral line are differently labeled, and a narrow transparent strip in the housing through which a strip is visible on the peripheral surface of the roller.
25. A mechanical counter according to claim 24, wherein said surfaces on two sides of the spiral line are marked with different colors.
26. A mechanical counter according to claim 24 or 25, further comprising a scale adjacent the transparent strip.
A mechanical counter according to any one of claims 1 to 21, further comprising a second spindle with a means for preventing unwanted displacement, which is arranged in a substantially parallel relationship to the first spindle (4), and a further slider with a rotary lock on the second spindle, and a one-tooth transmission assembly comprising a tooth arrangement at one end of the second spindle closest to the second housing part (2), and protrusions at the edge of the second housing part (2) that engage the tooth arrangement at the end by rotating the two housing parts (1, 2) relative to each other.
A metered dose inhaler comprising a nozzle assembly, an energy storage means, a reservoir, a valve arrangement, and having two coaxially arranged housing portions (1, 2) that rotate relative to each other when the dispensing apparatus is actuated, characterized in that: having a mechanical counter comprising a worm threaded spindle (4) mounted in the bearing means on the first housing part (1) in its peripheral region so as to be rotated by displacement of the second housing part (2), and an adjustable slider movable by the worm thread with respect to the scale means, the arrangement being such that the displacement of the slider relative to the scale means ensures the measurement of the number of activities of the apparatus.
A metered dose inhaler according to claim 28, wherein the slider comprises a display ring (9), at least one wing (10) having an engagement portion (11) with a screw thread, and at least one other. wing (13) with adjusting projection (12).
A metered dose inhaler according to claim 28 or 29, wherein the slider is releasable from the worm thread for adjustment.
A metered dose inhaler according to claim 29 or 30, wherein the slider wings (10, 13) are resilient.
A metered dose inhaler according to any one of claims 28 to 31, comprising means for indicating the number of times the slider has been moved over its displacement path.
-9EN 295757 B6
A metered dose inhaler according to any one of claims 28 to 32, characterized in that the axis of the spindle (4) is substantially parallel to the axis of rotation of the housing portions (1, 2), wherein the spindle (4) has a gear (22) which cooperates with the means on the second housing part (2) for rotating the spindle (4).
A metered dose inhaler according to claim 33, characterized in that half the rotation of the spindle (4) corresponds to a 360 ° rotational displacement of the two housing parts (1, 2) relative to each other.
A metered dose inhaler according to claim 33, characterized in that the spindle (4) is rotated periodically, the rotation being associated with the actuation of the metered dose inhaler, and said actuation being defined by relative rotation of the two parts (1). 2) bushings.
A metered dose inhaler according to claim 33, characterized in that the spindle (4) is rotated with each actuation of the metered dose inhaler, the trigger being defined by relative rotation of the two housing parts (1, 2). .
A metered dose inhaler according to any one of claims 28 to 36, characterized in that the spindle (4) has a rotatable locking means.
38. The metered dose inhaler according to claim 37, wherein the rotatable locking means is in the form of a latch.
-10GB 295757 B6
0BÍL.1
CZ19982049A 1995-12-28 1996-12-19 Mechanical counter for a metering apparatus and inhaler of metered doses CZ295757B6 (en)
CZ204998A3 CZ204998A3 (en) 1998-11-11
CZ295757B6 true CZ295757B6 (en) 2005-10-12
CZ19982049A CZ295757B6 (en) 1995-12-28 1996-12-19 Mechanical counter for a metering apparatus and inhaler of metered doses
PL2436453T3 (en) 2005-08-24 2014-03-31 Boehringer Ingelheim Int Atomiser comprising a counter and an end of operation lock
ES2446343T3 (en) * 2009-07-30 2014-03-07 Ivax International B.V. Dose counter for metered dose inhaler
1996-12-24 HR HR19549033.9A patent/HRP960617B1/en not_active IP Right Cessation
EP0853501B1 (en) 2003-08-27 Device of miniaturised construction for producing high pressure in a fluid to be atomised
ES2233659T3 (en) 2005-06-16 Medication inhaler.
EP0814861B1 (en) 2002-06-05 Ultrasonic atomizer device with removable precision dosing unit
CN1150038C (en) 2004-05-19 Dispenser with doses&#39;s cunter and doses indicator
ES2229495T3 (en) 2005-04-16 Inhaling device.
CN105597206B (en) 2019-09-20 Dose counter, inhalator and its axis for inhalator
DE69924395T2 (en) 2006-05-04 Inhaler
DE60030421T2 (en) 2007-02-08 Distribution device with a dosing metering device
ES2339574T3 (en) 2010-05-21 Dispensing device with counter.
DE69918700T2 (en) 2005-07-28 Inhaler
2010-07-28 MM4A Patent lapsed due to non-payment of fee