Source: http://www.google.com/patents/US20020128563?dq=6,712,702
Timestamp: 2016-06-01 04:28:24
Document Index: 82919802

Matched Legal Cases: ['art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115']

Patent US20020128563 - Cardiac rhythm management system using time-domain heart rate variablility ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA cardiac rhythm management system that provides an indication of patient well-being based on the autonomic balance between the sympathetic and parasympathetic/vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate interval signal....http://www.google.com/patents/US20020128563?utm_source=gb-gplus-sharePatent US20020128563 - Cardiac rhythm management system using time-domain heart rate variablility indiciaAdvanced Patent SearchPublication numberUS20020128563 A1Publication typeApplicationApplication numberUS 09/802,316Publication dateSep 12, 2002Filing dateMar 8, 2001Priority dateMar 8, 2001Also published asEP1365836A2, US6678547, US7248919, US20040193066, WO2002072196A2, WO2002072196A3Publication number09802316, 802316, US 2002/0128563 A1, US 2002/128563 A1, US 20020128563 A1, US 20020128563A1, US 2002128563 A1, US 2002128563A1, US-A1-20020128563, US-A1-2002128563, US2002/0128563A1, US2002/128563A1, US20020128563 A1, US20020128563A1, US2002128563 A1, US2002128563A1InventorsGerrard Carlson, Julio SpinelliOriginal AssigneeCarlson Gerrard M., Spinelli Julio C.Export CitationBiBTeX, EndNote, RefManReferenced by (96), Classifications (8), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetCardiac rhythm management system using time-domain heart rate variablility indicia
US 20020128563 A1Abstract
A cardiac rhythm management system that provides an indication of patient well-being based on the autonomic balance between the sympathetic and parasympathetic/vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate interval signal. Images(10) Claims(32)
What is claimed is: 1. A method including: detecting heart contractions over a time period; obtaining a time-domain first signal representing time intervals between the detected heart contractions; filtering the first signal to obtain a time-domain second signal including frequency components substantially in a first frequency band, wherein the second signal is influenced by both sympathetic and parasympathetic components of an autonomic nervous system; filtering the first signal to obtain a time-domain third signal including frequency components substantially in a second frequency band, wherein the third signal is influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system; and providing an indication associated with a balance between the sympathetic and parasympathetic components of the autonomic nervous system based on the time-domain second and third signals. 2. The method of claim 1, further including obtaining a variance of at least one of the second and third signals. 3. The method of claim 1, further including squaring at least one of the second and third signals. 4. The method of claim 3, further including lowpass filtering the squared one of the second and third signals. 5. The method of claim 1, further including: obtaining a variance of each of the second and third signals; and ratioing the variance of the second and third signals. 6. The method of claim 5, in which obtaining the variance of each of the second and third signals includes: squaring each of the second and third signals; and lowpass filtering the squared second and third signals. 7. The method of claim 5, further including lowpass filtering the ratioed variance of the second and third signals. 8. The method of claim 5, in which providing an indication associated with an autonomic nervous system includes extracting a signal feature of the ratioed variance of the second and third signals. 9. The method of claim 1, in which filtering the first signal to obtain a time-domain second signal includes bandpass filtering using a lowpass cutoff frequency that is approximately equal to 0.15 Hz and a highpass cutoff frequency that is approximately equal to 0.04 Hz. 10. The method of claim 1, in which filtering the first signal to obtain a time-domain third signal includes bandpass filtering using a lowpass cutoff frequency that is approximately equal to 0.40 Hz and a highpass cutoff frequency that is approximately equal to 0.15 Hz. 11. The method of claim 1, in which detecting heart contractions includes detecting ventricular heart contractions. 12. The method of claim 1, in which providing an indication associated with a balance between the sympathetic and parasympathetic components of the autonomic nervous system includes selecting a time period on which the indication is based by comparing intervals between heart contractions, during the time period, to a predetermined criterion. 13. The method of claim 12, in which selecting the time period on which the indication is based includes comparing intervals between heart contractions, during the time period, to a maximum value and an average value. 14. The method of claim 12, in which selecting the time period on which the indication is based is performed by determining when a patient is asleep or resting and using the selected time period for providing the indication associated with the autonomic nervous system. 15. The method of claim 1, further including providing therapy to the heart based on the indication associated with the balance between the sympathetic and parasympathetic components of the autonomic nervous system. 16. The method of claim 15, in which providing therapy includes providing antitachyarrhythmia therapy. 17. The method of claim 16, in which providing antitachyarrhythmia therapy includes providing antitachyarrhythmia pacing. 18. The method of claim 16, in which providing antitachyarrhythmia therapy includes providing an antiarrhythmic drug. 19. The method of claim 1, in which obtaining a time-domain first signal representing time intervals between the detected heart contractions includes: detecting R-wave peaks; measuring time intervals between R-wave peaks; providing a continuous-time R-R interval signal based on the measured time intervals between R-wave peaks; and sampling the continuous-time R-R interval signal using a plurality of sample points, that, when the sample points span a pair of R-R intervals, are weighted according to a time associated with each R-R interval in the pair of R-R intervals. 20. A method including: detecting heart contractions over a time period; obtaining a time-domain first signal representing time intervals between the detected heart contractions; bandpass filtering the first signal, using a lowpass cutoff frequency that is approximately equal to 0.15 Hz and a highpass cutoff frequency that is approximately equal to 0.04 Hz, to obtain a time-domain low frequency (LF) signal; bandpass filtering the first signal, using a lowpass cutoff frequency that is approximately equal to 0.40 Hz and a highpass cutoff frequency that is approximately equal to 0.15 Hz, to obtain a time-domain high frequency (HF) signal; and obtaining variances of the LF and HF signals; and ratioing the variances of the LF and HF signals to obtain an LF/HF ratio signal. 21. The method of claim 20, in which obtaining the variances includes squaring the IF and HF signals to obtain squared LF and HF signals, and lowpass filtering the squared LF and HF signals. 22. The method of claim 20, in which ratioing the variances of the LF and HF signals further includes lowpass filtering the LF/HF ratio signal to provide the indication of the balance between the sympathetic and parasympathetic components of the autonomic nervous system. 23. A system including: a heart contraction detection module, providing a heart rate interval signal carrying information regarding intervals between heart contractions; a low frequency (LF) bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the LF bandpass filter providing a time-domain LF signal output that is influenced by both sympathetic and parasympathetic components of an autonomic nervous system; a high frequency (HF) bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the HF bandpass filter providing a time-domain HF signal output having higher frequency components than the LF signal output, the HF signal output being influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system; an LF variance module coupled to the LF bandpass filter for receiving the LF signal, the LF variance module providing a resulting LF variance signal; a HF variance module, coupled to the HF bandpass filter for receiving the HF signal, the HF variance module providing a resulting HF variance signal; and an autonomic balance indicator module, coupled to the LF and HF variance modules, and providing an indication of a balance between sympathetic and parasympathetic components of the autonomic nervous system based on the LF and HF variance signals. 24. The system of claim 23, further including a ratioing module, coupled to each of the LF and HF variance modules for receiving the LF and HF variance signals, and providing an output ratio of the LF and HF variance signals, and in which the autonomic balance indicator is coupled to the LF and HF variance modules through the ratioing module, and in which the autonomic balance indicator provides an indication of the balance between sympathetic and parasympathetic components of the autonomic nervous system based on the ratio of the LF and HF variance signals provided by the ratioing circuit. 25. The system of claim 24, further including a lowpass filter, coupled to the ratioing circuit for receiving and filtering the ratio of the LF and HF variance signals for output to the autonomic balance indicator module. 26. The system of claim 23, in which the LF bandpass filter includes a lowpass cutoff frequency that is approximately equal to 0.15 Hz and a highpass cutoff frequency that is approximately equal to 0.04 Hz. 27. The system of claim 23, in which the HP bandpass filter includes a lowpass cutoff frequency that is approximately equal to 0.40 Hz and a highpass cutoff frequency that is approximately equal to 0.15 Hz. 28. The system of claim 23, further including a therapy module, adapted to be coupled to a heart, the therapy module providing therapy to the heart based at least in part on the indication of the balance between the sympathetic and parasympathetic components of the autononic nervous system. 29. The system of claim 23, further including a sleep detector module, coupled to the heart contraction detection module and the autonomic balance indicator module, the sleep detector module selecting a period of time for evaluating autonomic balance based on detected time intervals between heart contractions. 30. The system of claim 23, in which the heart rate contraction detection module includes a R-R interval sampling and filter module providing a sampled data heart rate interval signal including R-R interval information. 31. The system of claim 23, in which the heart rate contraction detection module includes a means for performing the function of sampling a continuous-time R-R interval signal and providing a filtered sampled data heart rate interval signal output including R-R interval information. 32. A system including: a heart contraction detection module, providing a heart rate interval signal carrying information regarding intervals between heart contractions; a bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the bandpass filter providing a time-domain bandpass filtered signal output; an variance module coupled to the bandpass filter for receiving the bandpass filtered signal, the variance module providing a resulting variance signal; an autonomic balance indicator module, coupled to the variance module, and providing an indication of a balance between sympathetic and parasympathetic components of an autonomic nervous system, based on the variance signal; and an antitachyarrhythmia therapy module, adapted to be coupled to a heart, the therapy module providing antitachyarrhythmia therapy to the heart based at least in part on the indication of the balance between the sympathetic and parasympathetic components of the autonomic nervous system. Description
TECHNICAL FIELD [0001] The present system relates generally to cardiac rhythm management systems and particularly, but not by way of limitation, to such a system using time-domain heart rate variability indicia. BACKGROUND [0002] When functioning properly, the human heart maintains its own intrinsic rhythm, and is capable of pumping adequate blood throughout the body's circulatory system. However, some people have irregular cardiac rhythms, referred to as cardiac arrhythmias. Such arrhythmias result in diminished blood circulation. One mode of treating cardiac arrhythmias uses drug therapy. Drugs are often effective at restoring normal heart rhythms. However, drug therapy is not always effective for treating arrhythmias of certain patients. For such patients, an alternative mode of treatment is needed. One such alternative mode of treatment includes the use of a cardiac rhythm management system. Such systems are often implanted in the patient and deliver therapy to the heart. [0003] Cardiac rhythm management systems include, among other things, pacemakers, also referred to as pacers. Pacers deliver timed sequences of low energy electrical stimuli, called pace pulses, to the heart, such as via an intravascular leadwire or catheter (referred to as a “lead”) having one or more electrodes disposed in or about the heart. Heart contractions are initiated in response to such pace pulses (this is referred to as “capturing” the heart). By properly timing the delivery of pace pulses, the heart can be induced to contract in proper rhythm, greatly improving its efficiency as a pump. Pacers are often used to treat patients with bradyarrhythmias, that is, hearts that beat too slowly, or irregularly. Such pacers coordinate atrial and ventricular contractions to improve pumping efficiency. Cardiac rhythm management systems also include coordination devices for coordinating the contractions of both the right and left sides of the heart for improved pumping efficiency. [0004] Cardiac rhythm management systems also include defibrillators that are capable of delivering higher energy electrical stimuli to the heart. Such defibrillators also include cardioverters, which synchronize the delivery of such stimuli to portions of sensed intrinsic heart activity signals. Defibrillators are often used to treat patients with tachyarrhythmias, that is, hearts that beat too quickly. Such too-fast heart rhythms also cause diminished blood circulation because the heart isn't allowed sufficient time to fill with blood before contracting to expel the blood. Such pumping by the heart is inefficient. A defibrillator is capable of delivering an high energy electrical stimulus that is sometimes referred to as a defibrillation countershock, also referred to simply as a “shock.” The countershock interrupts the tachyarrhythmia, allowing the heart to reestablish a normal rhythm for the efficient pumping of blood. In addition to pacers, cardiac rhythm management systems also include, among other things, pacer/defibrillators that combine the functions of pacers and defibrillators, drug delivery devices, and any other implantable or external systems or devices for diagnosing or treating cardiac arrhythmias. [0005] One problem faced by physicians treating cardiovascular patients is assessing patient well-being for providing a prognosis or for adjusting therapy to improve the patient's prognosis. Heart rate variability (“HRV”) is thought to provide one such assessment of cardiovascular health. The time interval between intrinsic ventricular heart contractions changes in response to the body's metabolic need for a change in heart rate and the amount of blood pumped through the circulatory system. For example, during a period of exercise or other activity, a person's intrinsic heart rate will generally increase over a time period of several or many heartbeats. However, even on a beat-to-beat basis, that is, from one heart beat to the next, and without exercise, the time interval between intrinsic heart contractions varies in a normal person. These beat-to-beat variations in intrinsic heart rate are the result of proper regulation by the autonomic nervous system of blood pressure and cardiac output; the absence of such variations indicates a possible deficiency in the regulation being provided by the autonomic nervous system. [0006] The autonomic nervous system itself has two components: sympathetic and parasympathetic (or vagal). The sympathetic component of the autonomic nervous system is relatively slow acting, and is associated with a tendency to raise heart rate, blood pressure, and/or cardiac output. The parasympathetic/vagal component of the autonomic nervous system, which provides a relatively faster response than the sympathetic component, is associated with a tendency to reduce heart rate, blood pressure, and/or cardiac output. A proper balance between the sympathetic and parasympathetic components of the autonomic nervous system is important. Therefore, an indication of this balance of the components of the autonomic nervous system, which is sometimes referred to as “autonomic balance,” “sympathetic tone,” or “sympathovagal balance,” provides a useful indication of the patient's well-being. [0007] One technique for providing an indication of the balance of the components of the autonomic nervous system is provided by the beat-to-beat heart rate variability, as discussed above. More particularly, intrinsic ventricular contractions are detected. The time intervals between these contractions, referred to as the R-R intervals, are recorded after filtering out any ectopic contractions, that is, ventricular contractions that are not the result of a normal sinus rhythm. This signal of R-R intervals is typically transformed into the frequency-domain, such as by using fast Fourier transform (“FFT”) techniques, so that its spectral frequency components can be analyzed. Two frequency bands are of particular interest: a low frequency (LF) band in the frequency (“f”) range 0.04 Hz≦f<0.15 Hz, and a high frequency (HF) band in the frequency range 0.15 Hz≦f≦0.40 Hz. The HF band of the R-R interval signal is influenced only by the parasympathetic/vagal component of the autonomic nervous system. The LF band of the R-R interval signal is influenced by both the sympathetic and parasympathetic components of the autonomic nervous system. Consequently, the ratio LF/HF is regarded as a good indication of the autonomic balance between sympathetic and parasympathetic/vagal components of the autonomic nervous system. An increase in the LF/HF ratio indicates an increased predominance of the sympathetic component, and a decrease in the LF/HF ratio indicates an increased predominance of the parasympathetic component. For a particular heart rate, the LF/HF ratio is regarded as an indication of patient wellness, with a lower LF/HF ratio indicating a more positive state of cardiovascular health. [0008] Such spectral analysis of the frequency components of the R-R interval signal has required an FFT (or other parametric transformation, such as autoregression) transformation from the time domain into the frequency domain. Implantable cardiac rhythm management devices, however, typically do not presently have the dedicated hardware to perform such FFT transformations. Even if an implantable cardiac rhythm management device did have such dedicated FFT hardware, performing the transformation would be computationally expensive, requiring increased power consumption, and shortening time during which the implanted battery-powered device can be used before its replacement is required. Therefore, there is a need to provide such an indication of patient well-being without requiring a computationally expensive transformation of the R-R interval signal into the frequency domain. SUMMARY [0009] This document describes a cardiac rhythm management system that provides an indication of patient well-being based on the autonomic balance between the sympathetic and vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate variability signal. [0010] In one embodiment, the cardiac rhythm management system provides a method that detects heart contractions over a time period. A time-domain first signal represents time intervals between the detected heart contractions. The first signal is filtered to obtain a time-domain second signal including frequency components substantially in a first frequency band. The first signal is also filtered to obtain a time-domain third signal including frequency components substantially in a second frequency band that is different from the first frequency band. Based on the second and third signals, the system provides an indication associated with an autonomic nervous system. [0011] In another embodiment, the cardiac rhythm management system provides a method that detects contractions of a heart over a time period. A time-domain first signal represents time intervals between the detected heart contractions. The first signal is filtered to obtain a time-domain second signal having frequency components substantially in a first frequency band. The system provides a substantially real-time time-domain indication, based on the second signal, of a balance between a sympathetic and a parasympathetic/vagal components of an autonomic nervous system. In a further embodiment, the system delivers therapy to a heart based on this indication of autonomic balance. [0012] In another embodiment, the cardiac rhythm management system includes a heart contraction detection module, providing a heart rate interval signal carrying information regarding intervals between heart contractions. A bandpass filter is coupled to the detection module for receiving the heart rate interval signal. The bandpass filter provides a time-domain bandpass filtered signal output. A variance module is coupled to the bandpass filter for receiving the bandpass filtered signal. The variance modules provides a resulting variance signal. An autonomic balance indicator module is coupled to the variance module, and provides an indication of a balance between sympathetic and parasympathetic components of an autonomic nervous system, based on the variance signal. In a further embodiment, a therapy module, which is adapted to be coupled to a heart, provides therapy to the heart based at least in part on the autonomic balance indication. Other aspects of the invention will be apparent on reading the following detailed description of the invention and viewing the drawings that form a part thereof.
BRIEF DESCRIPTION OF THE DRAWINGS [0013] In the drawings, which are not necessarily drawn to scale, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components. The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in the present document. [0014] [0014]FIG. 1 is a schematic/block diagram illustrating generally one embodiment of portions of a cardiac rhythm management system. [0015] [0015]FIG. 2 is a schematic/block diagram illustrating generally one embodiment of portions of a heart rate interval extraction module. [0016] [0016]FIG. 3 is a graph illustrating generally one embodiment of a technique for processing a signal that includes R-wave information including providing a substitute R-wave to replace a premature ventricular contraction (PVC) or ectopic beat. [0017] [0017]FIG. 4 is a graph illustrating generally one embodiment of a technique for processing a signal that includes R-wave information, including forming a continuous-time R-R interval signal and a sampled data heart rate interval signal that includes R-R interval information. [0018] [0018]FIG. 5 is a graph illustrating generally one embodiment of a technique for sampling and filtering a continuous-time R-R interval signal to obtain a resulting sampled data heart rate interval signal that includes R-R interval information. [0019] [0019]FIG. 6 is a graph illustrating generally one embodiment of a LF/HF signal representing autonomic balance based on an illustrated corresponding heart (e.g., R-R) interval signal, and illustrating generally one embodiment of a technique for extracting one or more features of the LF/HF signal to further quantify a state of the patient's well-being. [0020] [0020]FIG. 7 is a schematic/block diagram illustrating generally one embodiment of portions of a cardiac rhythm management device including a therapy module providing therapy based at least in part on the indication of autonomic balance. [0021] [0021]FIG. 8 is a schematic/block diagram illustrating generally one embodiment of portions of a cardiac rhythm management system including a means (such as a “sleep” detector) for identifying one or more particular time periods of interest for obtaining the indication of autonomic balance. [0022] [0022]FIG. 9 is a graph illustrating generally one technique for identifying a time period of interest for determining autonomic balance, in which the time period of interest is based on data regarding the intervals between heart contractions.
DETAILED DESCRIPTION [0023] In the following detailed description, reference is made to the accompanying drawings which form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that the embodiments may be combined, or that other embodiments may be utilized and that structural, logical and electrical changes may be made without departing from the spirit and scope of the present invention. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims and their equivalents. In the drawings, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components. The term “and/or” refers to a nonexclusive “or” (i.e., “A and/or B” includes both “A and B” as well as “A or B”). [0024] The present methods and apparatus will be described in applications involving implantable medical devices including, but not limited to, implantable cardiac rhythm management systems such as pacemakers, cardioverter/defibrillators, pacer/defibrillators, biventricular or other multi-site coordination devices, and drug delivery systems. However, it is understood that the present methods and apparatus may be employed in unimplanted devices, including, but not limited to, external pacemakers, cardioverter/defibrillators, pacer/defibrillators, biventricular or other multi-site coordination devices, monitors, programmers and recorders, whether such devices are used for providing a diagnostic, a therapy, or both a diagnostic and a therapy. [0025] This document describes a cardiac rhythm management system that provides an indication of patient well-being, based on an autonomic balance between the sympathetic and vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate interval signal. [0026] [0026]FIG. 1 is a schematic/block diagram illustrating generally one embodiment of portions of a cardiac rhythm management system 100. In this embodiment, system 100 includes, among other things, a cardiac rhythm management device 105 and a leadwire (“lead”) 110 for communicating signals between device 105 and a portion of a living organism, such as a heart 115. Embodiments of device 105 include, among other things, bradycardia and antitachycardia pacemakers, cardioverters, defibrillators, combination pacemaker/defibrillators, drug delivery devices, and any other implantable or external cardiac rhythm management apparatus capable of providing therapy and/or diagnostics to heart 115. System 100 may also include additional components such as, for example, a remote programmer 190 capable of communicating with device 105 via a transmitter or receiver, such as telemetry transceiver 187. [0027] In one embodiment, portions of system 100 (e.g., device 105) are implantable in the living organism, such as in a pectoral or abdominal region of a human patient, or elsewhere. In another embodiment, portions of system 100 (e.g., device 105) are alternatively disposed externally to the human patient. In the illustrated embodiment, portions of lead 110 are disposed in the right ventricle, however, any other positioning of lead 110 is included within the present invention. For example, in various alternative embodiments, lead 110 may alternatively be positioned in a location that is associated with the right atrium and/or superior vena cava, the coronary sinus or great cardiac vein, the left atrium or ventricle, epicardially, or elsewhere. In one embodiment, lead 110 is a commercially available bipolar pacing lead having a tip electrode 120 and a ring electrode 125 configured to be disposed in a right ventricle of heart 115. System 100 can also include other leads and/or electrodes in addition to lead 110, appropriately disposed, such as in or around heart 115, or elsewhere. For example, in one external embodiment, device 105 is not implanted and lead 110 provides external surface ECG electrode connections for sensing heart signals. In a unipolar example, implanted device 105 itself includes one or more electrodes for sensing heart signals or providing therapy, such as housing electrode 130 or header electrode 135. [0028] [0028]FIG. 1 also illustrates generally portions of device 105, together with schematic illustrations of example connections to the various electrodes. Device 105 includes a heart contraction detection module 137 that receives intrinsic heart signals from electrodes that are communicatively associated with heart 115. Module 137 provides an output heart rate interval signal carrying information about the time intervals between heart contractions. Because, as discussed above, the interval between heart contractions manifests intrinsic variations, the output heart rate interval signal provided by module 137 includes heart rate variability information. [0029] In one embodiment, module 137 includes a sense amplifier 140, which, in this illustration, is coupled to tip electrode 120 and ring electrode 125 for receiving intrinsic heart signals that include electrical depolarizations corresponding to heart contractions (right ventricular heart contractions, in this example). Sense amplifier 140 detects such input heart depolarizations and provides an output electrical signal carrying such information to subsequent portions of device 105. In a further embodiment, sense amplifier 140 also includes filtering or other signal processing circuits for detecting the desired electrical depolarizations associated with heart contractions, as is known in the art. Device 105 also includes an analog-to-digital (A/D) converter 145, which receives the sensed electrical depolarization signal and provides an output digital representation thereof. In a further embodiment, A/D converter 145 includes associated sample and hold circuits for sampling the electrical signal output by sense amplifier 140. Peak detector 150 receives the digitized signal from A/D converter 145 and detects signal peaks associated with heart contractions. In this embodiment, these signal peaks are the R-waves in the QRS complexes associated with ventricular heart contractions. However, it is understood that the disclosed structure and techniques could also be used to detect atrial heart contractions using P-waves associated with atrial depolarizations. [0030] In the illustrated embodiment, peak detector 150 outputs information about the timing of each R-wave to heart interval extraction module 155. Based on this information, heart rate interval extraction module 155 provides a discrete-time signal that is periodically sampled, i.e., the time difference between such samples is uniform. Each such sample includes an associated time interval (“heart rate interval”) corresponding to the detected heart rate. [0031] [0031]FIG. 2 is a schematic/block diagram, illustrating generally one embodiment of portions of heart rate interval extraction module 155, which includes an ectopic detection/processor module 200, an R-R interval calculation and storage module 205, and an R-R interval sampling and filter module 210. Heart rate interval extraction module 155 outputs a sampled data heart rate interval signal 215 that includes R-R interval information. In FIG. 2, ectopic detection/processor module 200 receives the detected R-wave peaks from peak detector 150. Module 200 deletes, replaces, and/or suppresses from further processing ectopic R-waves (sometimes referred to as premature ventricular contractions, or “PVCs”). Ectopic R-waves do not result from a normal sinus rhythm, that is, from a conducted atrial depolarization. [0032] In one embodiment, ectopic detection/processor module 200 also receives detected P-wave peaks, corresponding to atrial depolarizations, from electrodes associated with an atrium and sensed by an atrial sense amplifier (not shown). This embodiment of operating ectopic detection/processor module 200 is illustrated generally by the signal graph of FIG. 3. The input signal 300 of FIG. 3 illustrates instances of detected R-wave peaks, depicted by upward arrows. In FIG. 3, any detected R-wave for which no P-wave was detected since the preceding R-wave is deemed a PVC. PVCs are suppressed in output signal 305 from further signal processing. Such PVCs are replaced in output signal 305 by a substitute R-wave at the estimated time at which such R-wave would have occurred had there not been an ectopic event. In FIG. 3, beat number 10 represents a PVC that is replaced by a substitute R-wave. [0033] Many techniques exist for generating a substitute R-wave. In one example, the PVC is replaced by a substitute R-wave placed at time that is interpolated from that of following and preceding nonectopic R-waves. Because PVCs sometimes occur in groups, however, other techniques may also be used. Such techniques include using a moving average-like technique, spline-like technique, or median-like technique. A predetermined number of R-R intervals before and/or after the PVC may be used to calculate a time of occurrence of the substitute R-wave when a PVC occurs. [0034] [0034]FIG. 4 is a signal graph illustrating generally one embodiment of the operation of R-R interval calculation and storage module 205 and R-R interval sampling and filter module 210. R-R interval calculation and storage module 205 receives, from ectopic detection/processor module 200, a signal 220 including R-wave peaks with any substituted R-waves. Module 205 includes a timer that determines the R-R time interval between detected R-wave peaks, and stores the R-R intervals in memory to provide a resulting continuous time R-R interval signal 225. Signal 225 is sampled by module 210 to produce the resulting sampled data heart rate interval signal 215, which includes R-R interval information. [0035] In one embodiment, module 210 includes a sampling module that samples signal 225 at a sampling frequency, fs exceeding the Nyquist criterion. For example, if the maximum expected heart rate (after PVC removal) is 180 beats per minute, then a sampling rate that is greater than or equal to 6 Hz is sufficient. In one embodiment, this sampling module portion of module 210 also includes a finite impulse response (FIR) lowpass filter (or similar lowpass filter, averager, decimator, or downsampler) that provides a smoothed sampled data heart rate interval signal 210. [0036] In one embodiment, a three sample point FIR filter is used to sample and filter continuous time R-R interval signal 225. These sample points are separated from each by a time interval, ΔTs, where ΔTs is the inverse of the sampling frequency, fs. In operation, if the three sample points (at times t=ti−1, t1, and ti+1) fall within the same R-R interval of continuous time R-R interval signal 225, then that R-R interval value is used as the corresponding output sample, RRi. Otherwise, if the three sample points span a pair of R-R intervals (i.e., first and second R-R intervals, RR1 and RR2) on continuous time R-R interval signal 225, a weighted average of the first and second R-R interval values is used as the corresponding output sample, RRi. Each of the first and second R-R interval values is weighted according to the fraction of the time, (ti+1−ti−1) associated with that one of the first and second R-R intervals, RR1 and RR2. Operation of such a filter is illustrated generally by FIG. 5. [0037] [0037]FIG. 1 also illustrates a time-domain heart rate variability (HRV) signal processing module 160 that receives the heart rate interval signal 215 from heart rate interval extraction module 155, and provides a resulting indicator of patient well-being. In one embodiment of HRV signal processing module 160, the input heart rate interval signal 215 is received by a low frequency (LF) bandpass filter 165 and by a high frequency (HF) bandpass filter 170. In one embodiment, LF bandpass filter 165 is a finite impulse response (FIR) type filter having a lowpass cutoff frequency that is approximately equal to 0.15 Hz, and a highpass cutoff frequency that is approximately equal to 0.04 Hz. As a result, LF bandpass filter 165 outputs a filtered heart rate interval signal having frequency components that are primarily approximately between 0.04 Hz and 0.15 Hz inclusive. In this embodiment, HF bandpass filter 170 is an FIR type filter having a lowpass cutoff frequency that is approximately equal to 0.40 Hz, and a highpass cutoff frequency that is approximately equal to 0.15 Hz. As a result, HEF bandpass filter 170 outputs a filtered heart rate interval signal having frequency components approximately between 0.15 Hz and 0.40 Hz inclusive. Appropriate infinite impulse response (IIR) filter structures could also be used. Since the ultimate measurement of patient well-being is based on variance, waveform distortion is not of great concern and, therefore, the filter need not provide linear phase. [0038] LF variance module 175 and HF variance module 180 receive the output signals from LF bandpass filter 165 and HF bandpass filter 170, respectively. These variance modules 175 and 180 each perform a variance-type or similar computation, respectively outputting LF variance and HF variance signals to ratio module 185. In one embodiment, variance modules 175 and 180 each include a squaring circuit (i.e., a circuit that multiplies the input by itself to provide an output signal that is equivalent to the input signal raised to the second power) followed by a lowpass filter (or integrator or averager) to provide the resulting output signal. This squaring and lowpass filtering operation is equivalent to a variance computation that provides an indication of heart rate variability within the associated frequency range. In one embodiment, the lowpass filter used by variance modules 175 and 180 is an IIR type filter having a single lowpass pole with exponential weighting of past samples occurring during a moving time window that is approximately between 2 and 5 minutes, inclusive, in length. [0039] Ratio module 185 receives the LF and HF variance output signals from LF variance module 175 and HF variance module 180, respectively, and divides the value of the LF variance by the HF variance. The resulting LF/HF ratio output by ratio module 185 provides an indication of the sympathovagal balance between the sympathetic and parasympathetic/vagal components of the autonomic nervous system. As discussed above, an increase in the LF/HF ratio indicates an increased predominance of the sympathetic component, and a decrease in the LF/HF ratio indicates an increased predominance of the parasympathetic component. For a particular heart rate, the LF/HF ratio is regarded as an indication of patient wellness, with a lower LF/HF ratio indicating a more positive state of cardiovascular health. In one embodiment, this LF/HF ratio output by ratio module 185 is itself used as a patient wellness indicator. In further embodiments, however, this LF/HF ratio signal undergoes further processing, as discussed below. [0040] For example, in one such further embodiment, the LF/HF ratio signal output by ratio module 185 is received by a lowpass filter (or integrator or averager) 190 to provide additional smoothing of the indication of patient well-being. In one such example, lowpass filter 190 is implemented as an exponential-weighted averager (i.e., more recent samples are weighted more than older samples) over a sliding time window that is approximately between 2 minutes and 5 minutes inclusive, such as about 5 minutes. The resulting smoothed LF/HF ratio signal output by lowpass filter 190 provides a more stable indication of the patient's sympathovagal balance; one such smoothed LF/HF ratio signal is illustrated generally, by way of example, but not by way of limitation, in the graph of FIG. 3, together with a corresponding sample heart rate interval signal on which the smoothed LF/HF ratio is based. [0041] In a still further embodiment, the smoothed LF/HF ratio signal is received by autonomic balance indicator module 195 for further processing. In one example, module 195 includes a peak detector for obtaining the local minima and/or maxima of the smoothed LF/HF ratio signal, as illustrated in FIG. 6. Thus, in one embodiment, the indication of autonomic balance is based on one or more features of the smoothed LF/HF ratio signal, such as the local minima (e.g., using the lowest local minima during a given time period, an average of the local minima during a given time period, etc.), the local maxima, slope of the smoothed LF/HF ratio signal, and/or slope of portions of the LF/HF envelope (e.g., lines drawn between successive local minima and lines drawn between successive local maxima). In a further embodiment, the desired indication of autonomic balance is communicated by telemetry transceiver 187 to external programmer 190, such as for processing and/or for visual, audible, or other diagnostic display to the physician or other user. [0042] [0042]FIG. 7 is a schematic/block diagram illustrating generally, by way of example, and not by way of limitation, one embodiment of portions of device 105 including a controller 700 and a therapy module 705. Therapy module 705 provides cardiac rhythm management therapy to heart 115 via electrodes that are communicatively associated therewith. Examples of such therapy include, without limitation, atrial or ventricular pacing therapy, antitachyarrhythmia therapy, multi-site coordination therapy such as biventricular pacing, drug delivery. In one such embodiment, the parameters of such therapy are adjusted and/or optimized by controller 700 based at least in part on one or more indications of sympathetic/parasympathetic balance obtained from time-domain HRV signal processing module 160. For example, such parameters for providing dual chamber pacing therapy are well known in the art (e.g., rate, amplitude, pulsewidth, AV-delay, etc.); such parameters are adjusted, either individually or in combination, to increase or decrease a particular indication of autonomic balance (e.g., to decrease the lowest local minima of the smoothed LF/HF signal). Such parameter optimization is performed either in device 105 or, alternatively, in external programmer 190. [0043] In another example, the real-time (i.e., not substantially delayed) indicator of sympathetic/vagal balance provided by module 160 alerts the device to time periods during which heart 115 is particularly susceptible to tachyarrhythmias, such as when the smoothed or unsmoothed LF/HF signal increases (e.g., beyond a threshold value or at a rate that exceeds a threshold rate). In this embodiment, the increase in the LF/HF indication predicts the likely present or future onset of a tachyarrhythmia and, as a result, controller 700 triggers the delivery of preventative antitachyarrhythmia therapy to prevent the occurrence of the tachyarrhythmias. Such antitachyarrhythmia therapy includes antitachyarrhythmia pacing (ATP) sequences and/or antiarrhythmic drug therapy using drugs that increase parasympathetic and/or decrease sympathetic activity. Thus, this embodiment provides real-time control of therapy delivery based on the then-existing (or slightly delayed) indication of sympathetic/vagal balance. [0044] [0044]FIG. 8 is a schematic/block diagram illustrating generally, by way of example, but not by way of limitation one embodiment of portions of device 105 in which controller 700 (or, alternatively, external programmer 190) includes a “sleep detector” module 800 or other similar module for identifying one or more particular time periods of interest for obtaining the indication of sympathetic/vagal balance. In one embodiment, sleep detector 800 includes a long term (e.g., 24 hour) averager 805 for storing the long term average interval between heart contractions (e.g., R-R interval), and a long term (e.g., 24 hour) peak detector 810 for storing a corresponding long term maximum interval between heart contractions (e.g., maximum R-R interval). In this embodiment, autonomic balance indicator module 195 of FIG. 1 provides an indication of patient well-being based on sympathetic/vagal balance as obtained only when the interval between heart contractions exceeds the long term average value over a time period that: (1) extends forward in time from the time corresponding to the maximum interval between heart contractions to the first time, Tf, at which the interval between heart contractions drops back to the long term average value; and (2) extends backward in time from the time corresponding to the maximum interval between heart contractions to a time that is not more than 8 hours (by way of example) earlier than the time Tf. Intervals during this time period in which the interval between heart contractions is less than the long term average value are, in one embodiment, ignored for the purposes of providing an indication of sympathetic/parasympathetic balance. This described technique is illustrated generally, by way of example, but not by way of limitation, in FIG. 9. This technique is particularly useful for ascertaining longer term (e.g., over a period of days or months) variations in the patient's well-being as determined from sympathetic/parasympathetic balance. Because exercise, posture, and even being awake affect the sympathetic/parasympathetic balance, these factors are de-emphasized for ascertaining such longer term variations in the patient's well-being. While the time periods used in such techniques may be deemed “sleep,” as referred to in this document by the use of the term “sleep detector module,” it is understood that such times may not correspond exactly to periods during which the patient is sleeping. Other suitable time periods may also be used to de-emphasize components of the patient's sympathetic/vagal balance that tend to confound an assessment of long-term well-being. Conclusion [0045] This document describes, among other things, a cardiac rhythm management system that provides an indication of patient well-being based on the autonomic balance between the sympathetic and vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate interval signal. It is to be understood that the above description is intended to be illustrative, and not restrictive. For example, the above-described embodiments may be used in combination with each other. Many other embodiments will be apparent to those of skill in the art upon reviewing the above description. The scope of the invention should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled. In the appended claims, the terms “including” and “in which” are used as plain-English equivalents of the respective terms “comprising” and “wherein.” Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7366568Jun 13, 2005Apr 29, 2008Cardiac Pacemakers, Inc.Controlled delivery of intermittent stress augmentation pacing for cardioprotective effectUS7480528Jul 23, 2004Jan 20, 2009Cardiac Pacemakers, Inc.Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbiditiesUS7580745 *Jan 18, 2005Aug 25, 2009Cardiac Pacemakers, Inc.Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapyUS7664551Jul 6, 2005Feb 16, 2010Medtronic Transneuronix, Inc.Treatment of the autonomic nervous systemUS7668594Aug 19, 2005Feb 23, 2010Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapiesUS7672724Mar 2, 2010Cardiac Pacemakers, Inc.Method and apparatus for optimizing electrical stimulation parameters using heart rate variabilityUS7672725Mar 2, 2010Cardiac Pacemakers, Inc.Method and apparatus for using heart rate variability as a safety check in electrical therapiesUS7680534 *Mar 16, 2010Cardiac Pacemakers, Inc.Implantable cardiac device with dyspnea measurementUS7736319Jan 19, 2007Jun 15, 2010Cardiac Pacemakers, Inc.Ischemia detection using heart sound timingUS7833164Nov 16, 2010Cardiac Pacemakers, Inc.System and method for monitoring autonomic balance and physical activityUS7844334Nov 30, 2010Cardiac Pacemakers, Inc.Dual-use sensor for rate responsive pacing and heart sound monitoringUS7899519 *Jun 28, 2005Mar 1, 2011Cardiac Pacemakers, Inc.Evaluating a patient condition using autonomic balance information in implatable cardiac devicesUS7938781Jun 10, 2010May 10, 2011Cardiac Pacemakers, Inc.Hemodynamic stability assessment based on heart soundsUS7972275Dec 30, 2002Jul 5, 2011Cardiac Pacemakers, Inc.Method and apparatus for monitoring of diastolic hemodynamicsUS8000780Jun 27, 2006Aug 16, 2011Cardiac Pacemakers, Inc.Detection of myocardial ischemia from the time sequence of implanted sensor measurementsUS8027723Apr 24, 2008Sep 27, 2011Cardiac Pacemakers, Inc.Controlled delivery of intermittent stress augmentation pacing for cardioprotective effectUS8034000Oct 11, 2011Cardiac Pacemakers, Inc.Ischemia detection using a heart sound sensorUS8065003May 27, 2008Nov 22, 2011Cardiac Pacemakers, Inc.Demand-based cardiac function therapyUS8065010Nov 22, 2011Cardiac Pacemakers, Inc.Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbiditiesUS8108034Nov 28, 2005Jan 31, 2012Cardiac Pacemakers, Inc.Systems and methods for valvular regurgitation detectionUS8140155Mar 10, 2009Mar 20, 2012Cardiac Pacemakers, Inc.Intermittent pacing therapy delivery statisticsUS8211033Jul 3, 2012Cardiac Pacemakers, Inc.Third heart sound activity index for heart failure monitoringUS8214040Jul 3, 2012Cardiac Pacemakers, Inc.Intermittent stress augmentation pacing for cardioprotective effectUS8233987Jul 31, 2012Respicardia, Inc.Respiratory rectificationUS8239028 *Apr 24, 2009Aug 7, 2012Cyberonics, Inc.Use of cardiac parameters in methods and systems for treating a chronic medical conditionUS8244355Oct 29, 2004Aug 14, 2012Medtronic, Inc.Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous systemUS8298131 *Oct 30, 2012The Hong Kong Polytechnic UniversitySystem and method for relaxationUS8306615Nov 6, 2012Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapiesUS8332034Dec 10, 2010Dec 11, 2012Cardiac Pacemakers, Inc.Heart sound tracking system and methodUS8352020 *Aug 9, 2005Jan 8, 2013Centre Hospitalier Regional Universitaire De LilleMethod for processing a series of cardiac rhythm signals (RR) and the use thereof for analysing a cardiac rhythm variability, in particular for assessing a patient's pain or stressUS8412326Apr 2, 2013Cardiac Pacemakers, Inc.Pacemaker with vagal surge monitoring and responseUS8433396Apr 18, 2003Apr 30, 2013Medtronic, Inc.Methods and apparatus for atrioventricular searchUS8433412Feb 6, 2009Apr 30, 2013Respicardia, Inc.Muscle and nerve stimulationUS8483818Feb 23, 2011Jul 9, 2013Cardiac Pacemakers, Inc.Enhancements to the detection of pulmonary edema when using transthoracic impedanceUS8483826Mar 17, 2009Jul 9, 2013Cardiac Pacemakers, Inc.Deactivation of intermittent pacing therapyUS8500650Jul 2, 2012Aug 6, 2013Cardiac Pacemakers, Inc.Third heart sound activity index for heart failure monitoringUS8532769Oct 30, 2009Sep 10, 2013Medtronic, Inc.Heart rate variability distinctionUS8548586Jan 28, 2009Oct 1, 2013Cardiac Pacemakers, Inc.Configurable intermittent pacing therapyUS8597197Jun 8, 2012Dec 3, 2013Cardiac Pacemakers, Inc.Monitoring of heart soundsUS8611998Sep 22, 2011Dec 17, 2013Cardiac Pacemakers, Inc.Controlled delivery of intermittent stress augmentation pacing for cardioprotective effectUS8615296Mar 6, 2007Dec 24, 2013Cardiac Pacemakers, Inc.Method and apparatus for closed-loop intermittent cardiac stress augmentation pacingUS8636669Jan 5, 2011Jan 28, 2014Cardiac Pacemakers, Inc.Method and apparatus for monitoring of diastolic hemodynamicsUS8750992Aug 15, 2013Jun 10, 2014Cardiac Pacemakers, Inc.Implantable cardiac device with dyspnea measurementUS8758260Sep 13, 2011Jun 24, 2014Cardiac Pacemakers, Inc.Ischemia detection using a heart sound sensorUS8792986Feb 16, 2010Jul 29, 2014Medtronic, Inc.Treatment of the autonomic nervous systemUS8801624Oct 18, 2013Aug 12, 2014Cardiac Pacemakers, Inc.Monitoring of heart soundsUS8805503Feb 3, 2010Aug 12, 2014Cardiac Pacemakers, Inc.Method and apparatus for optimizing electrical stimulation parameters using heart rate variabilityUS8812104Sep 8, 2010Aug 19, 2014Cardiac Pacemakers, Inc.Method and apparatus for automated control of pacing post-conditioningUS8831724Jan 26, 2010Sep 9, 2014Cardiac Pacemakers, Inc.Method and apparatus for using heart rate variability as a safety check in electrical therapiesUS8840563Jul 2, 2013Sep 23, 2014Cardiac Pacemakers, Inc.Third heart sound activity index for heart failure monitoringUS8909341Jan 18, 2008Dec 9, 2014Respicardia, Inc.Device and method for the treatment of breathing disorders and cardiac disordersUS8954146Apr 16, 2014Feb 10, 2015Cardiac Pacemakers, Inc.Implantable cardiac device with dyspnea measurementUS8958873Apr 29, 2010Feb 17, 2015Cardiac Pacemakers, Inc.Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacingUS9049981Dec 7, 2012Jun 9, 2015Cardiac Pacemakers, Inc.Heart sound tracking system and methodUS9277885Feb 9, 2015Mar 8, 2016Cardiac Pacemakers, Inc.Implantable cardiac device with dyspnea measurementUS9295397Jun 16, 2014Mar 29, 2016Massachusetts Institute Of TechnologyMethod and apparatus for beat-space frequency domain prediction of cardiovascular death after acute coronary eventUS9295846Mar 27, 2013Mar 29, 2016Respicardia, Inc.Muscle and nerve stimulationUS20040215262 *Apr 18, 2003Oct 28, 2004Bozidar Ferek-PetricMethods and apparatus for atrioventricular searchUS20050256419 *May 17, 2004Nov 17, 2005University Technologies International Inc.Cardiac coupled resipirationUS20060020295 *Jul 23, 2004Jan 26, 2006Cardiac Pacemakers, Inc.Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbiditiesUS20060058851 *Jul 6, 2005Mar 16, 2006Valerio CigainaTreatment of the autonomic nervous systemUS20060094967 *Oct 29, 2004May 4, 2006Bennett Tommy DMethod and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous systemUS20060161208 *Jan 18, 2005Jul 20, 2006Cardiac Pacemakers, Inc.Method and apparatus for optimizing electrical stimulation parameters using heart rate variabilityUS20060161209 *Jan 18, 2005Jul 20, 2006Cardiac Pacemakers, Inc.Method and apparatus for using heart rate variability as a safety check in electrical therapiesUS20060161210 *Jan 18, 2005Jul 20, 2006Cardiac Pacemakers, Inc.Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapyUS20060167366 *May 7, 2003Jul 27, 2006Seijiro TomitaMethod and apparatus for extracting biological signal such as heartbeat or respirationUS20060195149 *Feb 28, 2005Aug 31, 2006Hopper Donald LImplantable cardiac device with dyspnea measurementUS20060253156 *Jun 13, 2005Nov 9, 2006Cardiac Pacemakers, Inc.Controlled delivery of intermittent stress augmentation pacing for cardioprotective effectUS20060293604 *Jun 28, 2005Dec 28, 2006Carlson Gerrard MEvaluating a patient condition using autonomic balance information in implatable cardiac devicesUS20070078491 *Aug 21, 2006Apr 5, 2007Cardiac Pacemakers, Inc.Third heart sound activity index for heart failure monitoringUS20080015652 *Jul 16, 2007Jan 17, 2008Cardiac Pacemakers, Inc.Dual-use sensor for rate responsive pacing and heart sound monitoringUS20080132801 *Aug 9, 2005Jun 5, 2008Centre Hospitalier Regional Universitaire De LilleMethod For Processing A Series Of Cardiac Rhythm Signals (Rr) And The Use Thereof For Analysing A Cardiac Rhythm Variability, In Particular For Assessing A Patient's Pain Or StressUS20080132968 *Feb 14, 2008Jun 5, 2008Medtronic, Inc.Cardiac activity control of gastric electrical stimulatorUS20080208282 *Jan 18, 2008Aug 28, 2008Mark GelfandDevice and method for the treatment of breathing disorders and cardiac disordersUS20080215105 *Apr 24, 2008Sep 4, 2008Cardiac Pacemakers, Inc.Controlled delivery of intermittent stress augmentation pacing for cardioprotective effectUS20080306564 *Jun 11, 2007Dec 11, 2008Cardiac Pacemakers, IncMethod and apparatus for short-term heart rate variability monitoring and diagnosticsUS20090043348 *Oct 14, 2008Feb 12, 2009Cardiac Pacemakers, Inc.Intermittent stress augmentation pacing for cardioprotective effectUS20090132000 *Jan 8, 2009May 21, 2009Cardiac Pacemakers, Inc.Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbiditiesUS20100113865 *Oct 31, 2008May 6, 2010The Hong Kong Polytechnic UniversitySystem and method for relaxationUS20100131026 *Jan 26, 2010May 27, 2010Pastore Joseph MMethod and apparatus for using heart rate variability as a safety check in electrical therapiesUS20100137932 *Feb 3, 2010Jun 3, 2010Pastore Joseph MMethod and apparatus for optimizing electrical stimulation parameters using heart rate variabilityUS20110060380 *Mar 10, 2011Mark GelfandRespiratory rectificationUS20110077707 *Mar 31, 2011Maile Keith RDual-use sensor for rate responsive pacing and heart sound monitoringUS20110105926 *Oct 30, 2009May 5, 2011Medtronic, Inc.Heart rate variability distinctionUS20110137367 *Jun 9, 2011Gerrard Merrill CarlsonEvaluating a patient condition using autonomic balance information in implantable cardiac devicesUS20160081619 *Aug 20, 2015Mar 24, 2016Cardiac Pacemakers, Inc.Sensor guided response to anti-arrhythmic changesEP2254069A1 *Jul 15, 2005Nov 24, 2010Cardiac Pacemakers, Inc.Method and apparatus for detecting cardiopulmonary comorbiditiesWO2004093987A2 *Apr 14, 2004Nov 4, 2004Medtronic, Inc.Methods and apparatus for atrioventricular searchWO2004093987A3 *Apr 14, 2004Mar 10, 2005Medtronic IncMethods and apparatus for atrioventricular searchWO2006028575A3 *Jul 15, 2005May 26, 2006Kenneth BeckMethod and apparatus for detecting cardiopulmonary comorbiditiesWO2006050144A1 *Oct 28, 2005May 11, 2006Medtronic, Inc.Method and apparatus to provide diagnostic index and therapy regulated by subject's autonomic nervous systemWO2006121842A2 *May 5, 2006Nov 16, 2006Cardiac Pacemakers, Inc.Controlled intermittent stress augmentation pacingWO2006121842A3 *May 5, 2006Apr 19, 2007Cardiac Pacemakers IncControlled intermittent stress augmentation pacingWO2011031427A1 *Aug 19, 2010Mar 17, 2011Cardiac Concepts, Inc.Respiratory rectificationWO2011053380A1 *May 3, 2010May 5, 2011Medtronic, Inc.Heart rate variability distinctionWO2014101913A1 *Dec 27, 2013Jul 3, 2014Biosign Medical UgMethod and device for quantifying a respiratory sinus arrhythmia and use of said type of method or said type of device* Cited by examinerClassifications U.S. Classification600/509International ClassificationA61N1/372, A61N1/362Cooperative ClassificationA61B5/4035, A61N1/362, A61N1/3622, A61N1/37252European ClassificationA61N1/362A2Legal EventsDateCodeEventDescriptionJul 9, 2001ASAssignmentOwner name: CARDIAC PACEMAKERS, INC., MINNESOTAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CARLSON, GERRARD M.;SPINELLI, JULIO C.;REEL/FRAME:011965/0006;SIGNING DATES FROM 20010531 TO 20010601Jul 13, 2007FPAYFee paymentYear of fee payment: 4Jun 15, 2011FPAYFee paymentYear of fee payment: 8Jul 1, 2015FPAYFee paymentYear of fee payment: 12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send 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