Source: https://patents.google.com/patent/US20090005865A1/en
Timestamp: 2019-06-26 07:22:01
Document Index: 12166544

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'art.\n1']

US20090005865A1 - Post-Implant Accommodating Lens Modification - Google Patents
US20090005865A1
US20090005865A1 US12/178,304 US17830408A US2009005865A1 US 20090005865 A1 US20090005865 A1 US 20090005865A1 US 17830408 A US17830408 A US 17830408A US 2009005865 A1 US2009005865 A1 US 2009005865A1
US10045844B2 (en
Terry W. Smiley
This application is a continuation-in-part of U.S. application Ser. No. 11/507,946, filed Aug. 21, 2006; which is a continuation-in-part of U.S. application Ser. No. 10/890,576, filed Jul. 14, 2004; which is a continuation-in-part of U.S. application Ser. No. 10/358,038, filed Feb. 3, 2003; which claims the benefit of U.S. Provisional Application No. 60/378,600, filed May 7, 2002; and U.S. Provisional Application No. 60/408,019, filed Sep. 3, 2003; and U.S. Provisional Application No. 60/353,847, filed Feb. 2, 2002; and U.S. Provisional Application No. 60/362,303, filed Mar. 6, 2002; and U.S. Provisional Application No. 60/431,110, filed Dec. 4, 2002; and U.S. Provisional Application No. 60/405,471, filed Aug. 23, 2002. Each of the aforementioned patent applications in this paragraph is hereby incorporated by reference herein in its entirety.
This application is a continuation-in-part of application Ser. No. 11/844,108, filed Aug. 23, 2007; which is a continuation of U.S. application Ser. No. 10/971,598, filed Oct. 22, 2004 (now U.S. Pat. No. 7,261,737); which is a continuation-in-part of U.S. application Ser. No. 10/734,514, filed Dec. 12, 2003 (now U.S. Pat. No. 7,122,053); which claims the benefit of U.S. Provisional Application No. 60/433,046, filed Dec. 12, filed 2002; all of which are hereby incorporated by reference herein in their entirety.
FIGS. 1A and 1B illustrate a sectional view of an exemplary accommodating IOL which incorporates components that utilize shape memory properties to enable accommodative adjustment of a lens. After the lens has been implanted into a lens capsular (after the native lens has been removed), the movement of the peripheral or non-optic body portion 512 from its memory shape MS to a temporary shape TS will cause compression of wall portion 528a against wall portion 528b to displace fluid media M from interior chambers 522A (collectively) to interior space 522B in lens optic portion 520 to alter anterior lens curvature to AC′ from AC. The scope of the invention includes any of a variety of mechanisms and cavity shapes in non-optic portion 512 that are compressed to cause fluid media flow to the optic portion 520. Also, the scope of the invention includes mechanisms and cavity shapes in non-optic portion 512 that are expanded to cause fluid media to flow from the optic portion. The interior space in the lens can be (i) centrally located or (ii) peripherally located in an annular region to thereby allow the deformation of the surface to add or subtract power in a plano lens, positive power lens, or negative power lens. The peripheral non-optic portion 512 (as can be seen in FIGS. 1A and 3); the non-optic portion 512 can comprise multiple elements) can provide its shape memory characteristics from a polymer material alone or a polymer in combination with a shape memory nickel titanium alloy (NiTi), which can be in the form of wire form or a thin film NiTi expanse embedded in the polymer to induce the non-optic portion 512 toward the memory shape as well as return interior chambers 522A to a “memory” volume. It can be seen that a substantial volume (first volume) of fluid media M is within the peripheral non-optic portion 512 and chambers 522A therein. In this untensioned or memory state, there is a limited volume of media M in the interior space or chamber 522B of the lens.
The shape of the open volume or pores can be molded in layers and assembled using soft lithographic techniques. Such micro-apertures can be microfabricated of a resilient polymer (e.g., silicone) by several different techniques, such as REM, μTM, MIMIC, SAMIM and several others-collectively given the name of soft lithography. For example, microtransfer molding is used wherein an elastomeric polydimethylsiloxane (PDMS) stamp has patterned relief on its surface to generate features in the polymer. The PDMS stamp is filled with a prepolymer or ceramic precursor and placed on a substrate. The material is cured and the stamp is removed. The technique generates features as small as 250 nm and is able to generate multilayer systems that can be used to fabricate the implant of the invention. Replica molding is a similar process wherein a PDMS stamp is cast against a conventionally patterned master. A polyurethane or other polymer is then molded against the secondary PDMS master. In this way, multiple copies can be made without damaging the original master. The technique can replicate features as small as 30 nm.
Another process is known as micromolding in capillaries (MIMIC) wherein continuous channels are formed when a PDMS stamp is brought into conformal contact with a solid substrate. Then, capillary action fills the channels with a polymer precursor. The polymer is cured and the stamp is removed. MIMIC can generate features down to 1 μm in size. Solvent-assisted microcontact molding (SAMIM) is also known wherein a small amount of solvent is spread on a patterned PDMS stamp and the stamp is 10 placed on a polymer, such as photoresist. The solvent swells the polymer and causes it to expand to fill the surface relief of the stamp. Features as small as 60 nm have been produced. Various microfabricated polymeric “open” volume structures can be understood to be feasible from review of any text on soft lithography, for example as in Xia and Whitesides, Annu. Rev. Mater. Sci. 1998 28:153-84. In particular, FIGS. 3( h), 7(a) to 7(f) and 8(a) to 8(f) illustrate polymeric microstructures.
FIGS. 18A-18C show an alternative embodiment in which the IOL comprises spacers 604 which perform similar function to the cushions of FIGS. 15A and 15B. The spacer includes web sections 608. If the webs are intact the haptic is held radially out from optic portion 600. If the webs are severed, the box section of the spacer collapses, lowering the pressure in the active channel of the optic (not shown). If only a portion of the webs are severed, then only that section of the spacer collapses, which gives a partial reduction in pressure. The physician can therefore severe all or some of the webs to control the amount of pressure change as is needed. The two spacers as shown in FIG. 18A have a difference number of web sections but the spacers can have the same number of web sections or any number of web sections. The web section can be externally actuated using any of the mechanisms described herein or that are known in the art.
1. A method of adjusting an optical parameter of an accommodating intraocular lens:
providing an accommodating intraocular lens comprising an optic portion in fluid communication with a peripheral portion, wherein movement of a fluid between the peripheral portion and the optic portion in response to ciliary muscle movement changes the optical power of the lens; and
altering fluid pressure within a portion of the intraocular lens such that the intraocular lens, in response to ciliary muscle movement, has a first optical power, and wherein after the fluid pressure has been altered, the intraocular lens, in response to the same ciliary muscle movement, has a second optical power different than the first optical power.
8. A method of adjusting an accommodating intraocular lens after implantation, comprising:
implanting an accommodating intraocular lens in a lens capsule, wherein the accommodating intraocular lens changes power in response to ciliary muscle movement; and
transferring a fluid media between a non-optic portion and an optic portion of the intraocular lens, wherein transferring the fluid media is not in response to ciliary muscle movement.
13. A method of adjusting an intraocular lens after implantation, comprising:
replacing a native lens with an intraocular lens, wherein the intraocular lens has a volume; and
adjusting the volume of the intraocular lens from a first volume to a second volume after the intraocular lens is implanted in a lens capsule.
19. A method of altering an optical parameter of an accommodating intraocular lens after implantation:
providing an accommodating intraocular lens comprising an optic portion in fluid communication with a peripheral portion;
wherein movement of a fluid between the peripheral portion and the optic portion in response to ciliary muscle movement changes the optical power of the lens; and
altering an optical parameter of the lens by applying energy to a portion of the intraocular lens from outside the patient.
24. An accommodating intraocular lens adapted for a post-implant modification, comprising:
a non-optic portion disposed peripherally from the optic portion and adapted to engage a lens capsule, wherein the intraocular lens is adapted to change power in response to ciliary muscle movement; and
an actuatable element adapted to be actuated by an external energy source to change an optical parameter of the intraocular lens.
34. An accommodating intraocular lens adapted for a post-implant modification, comprising:
a non-optic portion disposed peripherally from the optic portion and adapted to engage a lens capsule, wherein the intraocular lens is adapted to change power in response to ciliary muscle movement,
wherein the non-optic portion comprises an outer permeable layer adapted to allow fluid to pass through the permeable layer and into the eye.
39. A method of adjusting a lens capsule after an intraocular lens has been implanted therein, comprising:
implanting an intraocular lens within a lens capsule;
adjusting the diameter of the equator of the lens capsule after implanting the intraocular lens within the lens capsule, wherein adjusting the diameter of the equator of the lens capsule does not occur in response to ciliary muscle movement.
US20090005865A1 true US20090005865A1 (en) 2009-01-01
US10045844B2 US10045844B2 (en) 2018-08-14
US20170181850A1 (en) * 2014-03-28 2017-06-29 Forsight Labs, Llc Accommodating Intraocular Lens
US10285805B2 (en) * 2014-03-28 2019-05-14 Forsight Labs, Llc Accommodating intraocular lens
CN107624057A (en) * 2015-02-16 2018-01-23 诺华股份有限公司 Curvature-changing, accommodative intraocular lenses with expandable peripheral reservoirs
US10045844B2 (en) 2018-08-14