Source: http://www.google.com/patents/US7155295?dq=7,403,220
Timestamp: 2018-01-19 02:32:17
Document Index: 748152164

Matched Legal Cases: ['art.\n47', 'art.\n48', 'art.\n49', 'art.\n50', 'art, 60', 'art, 90', 'art, 120', 'art 2']

Patent US7155295 - Cardiac harness for treating congestive heart failure and for defibrillating ... - Google Patents
A system for treating the heart includes a cardiac harness associated with a cardiac rhythm management devise which includes at least electrodes and a power source. The cardiac harness applies a compressive force on the heart during diastole and systole. The electrodes will deliver an electrical shock...http://www.google.com/patents/US7155295?utm_source=gb-gplus-sharePatent US7155295 - Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing
Publication number US7155295 B2
Application number US 10/704,376
Also published as CA2543365A1, EP1687059A1, US7146226, US7149588, US7164952, US7187984, US7225036, US20050102010, US20050102011, US20050102012, US20050102014, US20050102015, US20050119717, US20070112390, WO2005046789A1
Publication number 10704376, 704376, US 7155295 B2, US 7155295B2, US-B2-7155295, US7155295 B2, US7155295B2
Inventors Lilip Lau, Matthew G. Fishler, Craig Mar
Patent Citations (112), Non-Patent Citations (78), Referenced by (32), Classifications (12), Legal Events (6)
Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing
US 7155295 B2
46. The systemof claim 45, wherein the electrodes being spaced about 180° apart.
47. The system of claim 45, wherein the electrodes being spaced about 120° apart.
48. The system of claim 45, wherein the electrodes being spaced about 90° apart.
49. The system of claim 45, wherein the electrodes being spaced about 60° apart.
50. The system of claim 45, wherein the electrodes being spaced about 45° apart.
The number of electrodes and the number of panels forming the cardiac harness is a matter of choice. For example, in one embodiment the cardiac harness can include two panels separated by two electrodes. The electrodes would be positioned 180° apart, or in some other orientation so that the electrodes could be positioned to provide a optimum electrical shock to the epicardial surface of the heart, preferably adjacent the right ventricle or the left ventricle. In another embodiment, the electrodes can be positioned 180° apart so that the electrical shock carries through the myocardium adjacent the right ventricle thereby providing an optimal electrical shock for defibrillation or periodic shocks for pacing. In another embodiment, three leads are associated with the cardiac harness so that there are three panels separated by the three electrodes.
In further keeping with the invention, the cardiac harness 20 includes a pair of leads 31 having conductive electrode portions 32 that are spaced apart and which separate panels 21. As shown in FIG. 5, the electrodes are formed of a conductive coil wire 33 that is wrapped around a non-conductive member 34, preferably in a helical manner. A conductive wire 35 is attached to the coil wire and to a power source 36. As used herein, the power source 36 can include any of the following, depending upon the particular application of the electrode: a pulse generator; an implantable cardioverter/defibrillator; a pacemaker; and an implantable cardioverter/defibrillator coupled with a pacemaker. In the embodiment shown in FIG. 5, the electrodes are configured to deliver an electrical shock, via the conductive wire and the power source, to the epicardial surface of the heart so that the electrical shock passes through the myocardium. Even though the electrodes are spaced so that they would be about 180° apart around the circumference of the heart in the embodiment shown, they are not so limited. In other words, the electrodes can be spaced so that they are about 45° apart, 60° apart, 90° apart, 120° apart, or any arbitrary arc length spacing, or, for that matter, essentially any arc length apart around the circumference of the heart in order to deliver an appropriate electrical shock. As previously described, it may become necessary to defibrillate the heart and the electrodes 32 are configured to deliver an appropriate electrical shock to defibrillate the heart.
In another embodiment as shown in FIGS. 7A and 7B, a different configuration for cardiac harness 20 and the electrodes 32 are shown, as compared to the FIG. 5 embodiments. In FIGS. 7A and 7B, three electrodes are shown separating the three panels 21 with undulating strands 22 extending between the electrodes. As with previous embodiments, springs 23 are formed by the undulating strands so that the undulating strands can expand and contract during the diastolic and systolic functions, and apply a compressive force during both functions. The far side panel of FIG. 7A is not shown for clarity purposes. The position of the electrodes around the circumference of the heart is a matter of choice, and in the embodiment of FIG. 7A, the electrodes can be spaced an equal distance apart at about 120°. Alternatively, it may be important to deliver the electrical shock more through the right ventricle requiring the positioning of the electrodes closer to the right ventricle than to the left ventricle. Similarly, it may be more important to deliver an electrical shock to the left ventricle as opposed to the right ventricle. Thus, positioning of electrodes, as with other embodiments, is a matter of choice.
In further keeping with the invention of FIGS. 20–23, a dielectric material such as silicone rubber 126 can be used to coat electrodes 120. During the molding process (previously described), when the electrode 120 is attached to the cardiac harness, silicone rubber 126 will coat the entire electrode 120. Soda blasting (or other known material removal process) can be used to remove portions of the silicone rubber skin from the coils 121 in order to expose first surface 123 and second surface 124 (or portions of those surfaces) so that the bare metal coil is exposed to the epicardial surface of the heart. Preferably, the silicone rubber is removed from both the first surface and the second surface, however, it also may be advantageous to remove the silicone rubber from only the first surface, which is proximate to or in contact with the epicardial surface of the heart. The electrode 120 has a surface area 128 which essentially includes all of the bare metal surface area that is exposed and that will deliver a shock. The amount of surface area per electrode can vary greatly depending upon a particular application, however, surface areas in the range from about 50 mm2 to about 600 mm2 are typical. While it is possible to remove the silicone rubber from only the second surface (facing away from the heart), and leaving the first surface coated with silicone rubber, an electrical shock can still be delivered from the bare metal second surface, however, the electrical shock delivered may not be as efficient as with other embodiments. While the dimensions of the electrodes can vary widely due to the variations in the size of the heart to be treated in conjunction with the size of the cardiac harness, generally the length of the electrode ranges from about 2 cm to about 16 cm. The coil 121 has a length in the range of about 1 cm to about 12 cm. Commercially available leads having one or more electrodes are available from several sources and may be used with the cardiac harness of the present invention. Commercially available leads with one or more electrodes is available from Guidant Corporation (St. Paul, Minn.), St. Jude Medical (Minneapolis, Minn.) and Medtronic Corporation (Minneapolis, Minn.). Further examples of commercially available cardiac rhythm management devices, including defibrillation and pacing systems available for use in combination with the cardiac harness of the present invention (possibly with some modification) include, the CONTAK CD®, the INSIGNIA® Plus pacemaker and FLEXTREND® leads, and the VITALITY™ AVT® ICD and ENDOTAK RELIANCE® defibrillation leads, all available from Guidant Corporation (St. Paul, Minn.), and the InSync System available from Medtronic Corporation (Minneapolis, Minn.).
It may be desired to reduce the likelihood of the development of fibrotic tissue over the cardiac harness so that the elastic properties of the harness are not compromised. Also, as fibrotic tissue forms over the cardiac harness and electrodes over time, it may become necessary to increase the power of the pacing stimuli. As fibrotic tissue increases, the right and left ventricular thresholds may increase, commonly referred to as “exit block.” When exit block is detected, the pacing therapy may have to be adjusted. Certain drugs such as steriods, have been found to inhibit cell growth leading to scar tissue or fibrotic tissue growth. Examples of therapeutic drugs or pharmacologic compounds that may be loaded onto the cardiac harness or into a polymeric coating on the harness, on a polymeric sleeve, on individual undulating strands on the harness, or infused through the lumens in the electrodes and delivered to the epicardial surface of the heart include steroids, taxol, aspirin, prostaglandins, and the like. Various therapeutic agents such as antithrombogenic or antiproliferative drugs are used to further control scar tissue formation. Examples of therapeutic agents or drugs that are suitable for use in accordance with the present invention include 17-beta estradiol, sirolimus, everolimus, actinomycin D (ActD), taxol, paclitaxel, or derivatives and analogs thereof. Examples of agents include other antiproliferative substances as well as antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, and antioxidant substances. Examples of antineoplastics include taxol (paclitaxel and docetaxel). Further examples of therapeutic drugs or agents include antiplatelets, anticoagulants, antifibrins, antiinflanmatories, antithrombins, and antiproliferatives. Examples of antiplatelets, anticoagulants, antifibrins, and antithrombins include, but are not limited to, sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogs, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist, recombinant hirudin, thrombin inhibitor (available from Biogen located in Cambridge, Mass.), and 7E-3B® (an antiplatelet drug from Centocor located in Malvern, Pa.). Examples of antimitotic agents include methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin. Examples of cytostatic or antiproliferative agents include angiopeptin (a somatostatin analog from Ibsen located in the United Kingdom), angiotensin converting enzyme inhibitors such as Captopril® (available from Squibb located in New York, N.Y.), Cilazapril® (available from Hoffman-LaRoche located in Basel, Switzerland), or Lisinopril® (available from Merck located in Whitehouse Station, N.J.); calcium channel blockers (such as Nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, Lovastatin® (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug from Merck), methotrexate, monoclonal antibodies (such as PDGF receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor (available from GlaxoSmithKline located in United Kingdom), Seramin (a PDGF antagonist), serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. Other therapeutic drugs or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, and dexamethasone.
US2278926 Feb 15, 1941 Apr 7, 1942 Metal Textile Corp Knitted metallic fabric for belting and other uses
US4428375 Feb 16, 1982 Jan 31, 1984 Ellman Barry R Surgical bag for splenorrhaphy
US5800528 Dec 29, 1995 Sep 1, 1998 Abiomed R & D, Inc. Passive girdle for heart ventricle for therapeutic aid to patients having ventricular dilatation
US6169922 * Nov 18, 1998 Jan 2, 2001 Acorn Cardiovascular, Inc. Defibrillating cardiac jacket with interwoven electrode grids
US6730016 * Jun 12, 2000 May 4, 2004 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6876887 * Jun 13, 2001 Apr 5, 2005 Acorn Cardiovascular, Inc. Cardio therapeutic heart sack
US20030199955 * Apr 22, 2002 Oct 23, 2003 Chester Struble Cardiac restraint with electrode attachment sites
US20040143154 * Sep 5, 2003 Jul 22, 2004 Lilip Lau Cardiac harness
US20050102011 * Feb 12, 2004 May 12, 2005 Lilip Lau Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing
6 Anstadt, George L., et al., A New Instrument for Prolonged Mechanical Cardiac Massage, Abstracts of the 38<SUP>th </SUP>Scientific Sessions, Supplement II to Circulation, vols. 31 and 32, pp. 375-384, Oct. 1965.
7 Anstadt, Mark P. et al., Direct Mechanical Ventricular Actuation: A Review, Resuscitation, pp. 7-23, 1991.
9 Application for U.S. Appl. No. 09/952,145 filed Sep. 10, 2001.
10 Application for U.S. Appl. No. 09/952,145, filed Sep. 10, 2001 published on Feb. 14, 2003 as Pub. No. 02-0019580-A 1; Inventors: Lau et al.
11 Application for U.S. Appl. No. 10/314,696 filed Dec. 9, 2002.
12 Application for U.S. Appl. No. 10/314,696, filed Dec. 9, 2002 published on Apr. 3, 2003 as Pub. No. 03-0065248-A 1; Inventors: Lau et al.
13 Application for U.S. Appl. No. 10/698,237 filed Oct. 31, 2003.
14 Application for U.S. Appl. No. 10/698,237, filed Oct. 31, 2003 published on Jul. 29, 2004 as Pub. No. 04-0147805-A 1; Inventor: Lau.
15 Application for U.S. Appl. No. 10/704,376 filed Nov. 7, 2003.
16 Application for U.S. Appl. No. 10/704,376, filed Nov. 7, 2003; Inventor: Lau.
17 Application for U.S. Appl. No. 10/715,150 filed Nov. 17, 2003.
18 Application for U.S. Appl. No. 10/715,150, filed Nov. 17, 2003 published on Mar. 10, 2005 as Pub. No. 05-0055032; Inventor: Lau.
19 Badhwar, Vinay, Power Generation From Four Skeletal Muscle Configurations Design Implications for a Muscle Powered Cardiac Assist Device, ASAIO Journal, vol. 43, pp. M651-M657, 1997.
20 Bencini, Adriano, M.D., The "Pneumomassage" of the Heart, Surgery, vol. 39, No. 3, Mar. 1956.
21 Bocchi, Edimar a., M.D., Arrhythmias and Sudden Death After Dynamic Cardiomyoplasty, Circulation, vol. 90, No. 5, Part 2, pp. II-I07 thru II-III, Nov. 1994.
22 Capomolla, Soccorso, M.D., et al., Dobutamine and Nitroprusside Infusion in Patients With Severe Congestive Heart Failure: Hemodynamic Improvement by Discordant Effects on Mitral Regurgitation, Left Atrial Function, and Ventricular Function, American Heart Journal, 1089-1098; Dec. 1997.
23 Capouya, Eli R., M.D., et al., Girdling Effect of Nonstimulated Cardiomyoplasty on Left Ventricular Function, Annals of Thoracic Surgeons, vol. 56, pp. 867-871, 1993.
24 Carpenter, A., et al., Myocardial Substitution With Stimulated Skeletal Muscle: First Successful Clinical Case, The Lancet, Jun. 1, 1985.
25 Carpentier, Alain, M.D., Ph.D., et al., Dynamic Cardiomyoplasty at Seven Years, The Journal of Thoracic and Cardiovascular Surgery, vol. 106, No. 1, pp. 42-54, Jul. 1993.
26 Chachques, Juan C., M.D., Study of Muscular and Ventricular Function in Dynamic Cardiomyoplasty: A Ten-Year Follow-Up, The Journal of Heart and Lung Transplantation, vol. 16, No. 8, pp. 854-868, Aug. 1997.
27 Chaudhry, Pervaiz A., M.D., et al., Acute Ventricular Reduction with Acorn's Cardiac Support Device Prevents Progressive Left Ventricular Dysfunction and Remodeling in Dogs With Advanced Heart Failure, Cardiothoracic Surgery, pp. 146-148, 1996.
28 Chaudhry, Pervaiz A., M.D., et al., Passive Epicardial Containment Prevents Ventricular Remodeling in a Heart Failure, Annals of Thoracic Surgeons, vol. 70, pp. 1275-1280, 2000.
29 Chekanov, Valeri, M.D., Ph.D., Nonstimulated Cardiomyoplasty Wrap Attenuated the Degree of Left Ventricular Enlargement, Annals of Thoracic Surgeons, vol. 57, pp. 1684-1690, 1997.
30 Chiu, Ray C.-J, Using Skeletal Muscle for Cardiac Assisatance, Scientific American, pp. 68-77, Nov./Dec. 1994.
31 Cohn, Jay N., M.D., Preventing Congestive Heart Failure, American Family Physician, 6 pages, Apr. 15, 1998.
32 Cohn, Jay N., M.D., Structural Basis for Heart Failure: Ventricular Remodeling and Its Pharmacological Inhibition, Circulation, vol. 91, No. 10, pp. 2504-2507, May 15, 1995.
33 Cohn, Jay N., M.D., The Management of Chronic Heart Failure, The New England Journal of Medicine, vol. 335, No. 7, pp. 490-498, Aug. 15, 1996.
34 Coletta, C., et al., Prognostic Value of Left Ventricular Volume Reponse During Dobutamine Stress Echocardiography, European Heart Journal, vol. 18, pp. 1599-1603, Oct. 1997.
35 Cox, James L., Left Ventricular Aneurysms: Pathophysiologic Observations and Standard Resection, Seminars in Thoracic and Cardiovascular Surgery, vol. 9, No. 2, pp. 113-122, Apr. 1997.
36 Doty, Donald B., et al., Septation of the Univentricular Heart: Transatrial Approach, The Journal of Thoracic and Cardiovascular Surgery, vol. 78, No. 3, pp. 424-430, Sep. 1979.
37 Dullum, Mercedes K.C., M.D., et al., Less Invasive Surgical Management of Heart Failure by Cardiac Support Device Implantation on the Beating Heart, The Heart Surgery Forum. #2001-1818, pp. 361-363, Jan. 4-7, 2001.
38 Edie, Richard N., M.D., et al., Surgical Repair of Single Ventricle, The Journal of Thoracic and Cardiovascular Surgery, vol. 66, No. 3, pp. 350-360, Sep. 1972.
39 Feldt, Robert H., M.D., et al., Current Status of the Septation Procedure for Univentricular Heart, The Journal of Thoracic and Cardiovascular Surgery, vol. 82, No. 1, pp. 93-97, Jul. 1981.
40 Frazier, O.H., M.D., et al., Left Ventricular Assist System as a Bridge to Myocardial Recovery, Annals of Thoracic Surgery, vol. 68, pp. 734-741, 1999.
41 Gaudron, Peter, M.D., et al., Progressive Left Ventricular Dysfunction and Remodeling After Myocardial Infarction, Circulation, vol. 87, pp. 755-763, Mar. 1993.
42 Gorman, J., Self-Sutures: New Material Knots Up On Its Own, Science News, vol. 161, p. 262, Apr. 27, 2002.
43 Guasp, Francisco Torrent, Una protesis contentiva para el tratamiento de le microcardiopatia dilatads, Revista Española de Cardiologia, vol. 51, No. 7, Jul. 1998.
44 Heart "jacket" could help stop heart failure progression, Clinicia, No. 916, Jul. 2000.
45 Kass, David A., M.D., et al., Reverse Remodeling From Cardiomyoplasty in Human Heart Failure: External Constraint Versus Active Assist, Circulation, vol. 91, No. 9, pp. 2314-2318, May 1, 1995.
46 Lev, Maurice, M.D., et al., Single (Primitive) Ventricle, Circulation, vol. 39, pp. 577-591.
47 Levin, Howard, R., M.D., et al., Reversal of Chronic Ventricular Dilation in Patients With End-Stage Cardiomyopathy by Prolonged Mechanical Unloading, Circulation, vol. 91, No. 11, pp. 2717-2720, 1995.
48 Macris, Michael P. M.D., et al., Minimally Invasive Access of the Normal Preicardium: Initial Clinical Experience with a Novel Device, Clinical Cardiology, vol. 22 (Suppl. 1), pp. I-36 thru I-39, 1999.
49 Mann, Douglas L., M.D., Basic Mechanisms of Remodeling and Reverse Remodeling, presented at 6<SUP>th </SUP>Annual Scientific Meeting of the Heart Failure Society of America, Sep. 24, 2002.
50 McCarthy, Patrick M., et al., Device Based Left Ventricular Shape Change Immediately Reduces Left Ventricular Volume and Increases Ejection Fraction in a Pacing Induced Cardiomyopathy Model in Dogs, JACC, Feb. 2000.
51 McGoon, Dwight C., M.D., et al., Correction of the Univentricular Heart Having Two Atriovantricular Valves, The Journal of Thoracic and Cardiovascular Surgery, vol. 74, No. 2, pp. 218-226, Aug. 1977.
52 Medtronic's InSync Cardiac Resynchronization Therapy Device Approved by FDA, (Press Release) Aug. 28, 2001.
53 Melton, K.N., et al., Alloys With Two-Shape Memory Effect, Mechanical Engineering, pp. 42-43, Mar. 1980.
54 Melvin, David B., Ventricular Radium Reduction Without Resection: A Computational Analysis, ASAIO Journal, pp. 160-165, 1999.
55 * Merram-Webster Online, 9www.webster.com), defined: dielectric
56 Oh, Joong Hwan, M.D., et al., Mechanisms of Dynamic Cardiomyoplasty: Current Concepts, Journal of Cardiac Surgery, vol. 11, pp. 194-199, 1996.
57 Oh, Joong Hwan, The Effects of Prosthetic Cardiac Binding and Adynamic Cardiomyoplasty in a Model of Dilated Cardiomyopathy, The Journal of Thoracic and Cardiovascular Surgery, vol. 116, No. 1, pp. 148-153, 1998.
58 Oz, Mehmet C., M.D., Passive Ventricular Constraint for the Treatment of Congestive Heart Failure, Annals of Thoracic Surgery, vol. 71, pp. 5185-5187, 2001.
59 Paling, D.F., Warp Knitting Technology, 1970.
60 Pfeffer, Marc a., M.D., Ph.D., et al., Ventricular Remodeling After Myocardial Infarction: Experimental Observations and Clinical Implications, Circulation, vol. 81, No. 4, pp. 21-32, Apr. 1990.
61 Pfeiffer, Marc A., M.D., et al., Ventricular Remodeling After Myocardial Infarction: Experimental Observations and Clinical Implications, Circulation, vol. 81, No. 4, pp. 1161-1172, Apr. 1990.
62 Power, J.M., et al., Passive Ventricular Constraint Amends the Course of Heart Failure: A Study in an Ovine Model of Dilated Cardiomyopathy, Cardiovascular Research, vol. 44, pp. 549-555, 1999.
63 Raman, Jai S., Fracs, et al., Ventricular Containment as an Adjunctive Procedure in Ischemic Cardiomyopathy: Early Results, Annals of Thoracic Surgery, vol. 70, pp. 1124-1126, Jan. 2000.
64 Savage, Edward B., M.D., et al., Repair of Left Ventricular Aneurysm, The Journal of Thoracic and Cardiovascular Surgery, vol. 104, No. 3, pp. 752-762, Sep. 1992.
65 Schetky, L. McDonald, Shap- Memory Alloys, Scientific American, vol. 241, No. 5, pp. 74-82, Nov. 1979.
67 Shabetai, Ralph, The Role of the Pericardium in the Pathophysiology of Heart Failure, Congestive Heart Failure, Second Edition, Chapter 9, pp. 157-187, 2000.
68 Teckell-Taylor, Leah A., et al., Passive Ventricular Restraint With Nitinol Mesh Attenuates Remodeling Following Acute Myocardial Infarction, Abstract, American College of Cardiology, (Undated).
69 Thakur, Ranjan K., M.D., et al., Latissimus Dorsi Dynamic Cardiomyoplasty: Role of Combined ICD Implantation, Journal of Cardiac Surgey, vol. 10, pp. 295-297, 1995.
70 U.S. Appl. No. 60/482,062 filed Jul. 10, 2003.
71 U.S. Appl. No. 60/486,062, filed Jul. 10, 2003; Inventors: Hong et al.
72 U.S. Appl. No. 60/535,888 filed Jan. 12, 2004.
73 U.S. Appl. No. 60/535,888 filed Jan. 12, 2004; Inventors: Fishler et al.
74 Vaynblat, Mikhail, M.D., et al., Cardiac Binding in Experimental Heart Failure, Annals of Thoracic Surgery (Abstract), Supplement to Circulation, vol. 92, Suppl. I, 1995.
75 Vaynblat, Mikhail, M.D., et al., Cardiac Binding in Experimental Heart Failure, Annals of Thoracic Surgery, vol. 64, pp. 81-85, 1997.
76 Westaby, Stephen, et al., Landmarks in Cardiac Surgery, pp. 198-199, 1997.
77 Wharton, J. Marcus, et al., Electrophysiological Effects of Monophasic and Biphasic Stimuli in Normal and Infarcted Dogs, PACE, vol. 13, pp. 1158-1172, Sep. 1990.
78 Wood, Alastair J.J., M.D., Editor, Review of Cohn, Jay N., M.D., The Management of Chronic Heart Failure, The New England Journal of Medicine: Review Article, vol. 335, No. 7, pp. 490-498, Aug. 15, 1996.
US7587247 * Aug 1, 2005 Sep 8, 2009 Paracor Medical, Inc. Cardiac harness having an optimal impedance range
US7722529 * Dec 23, 2005 May 25, 2010 Palo Alto Investors Expandable vessel harness for treating vessel aneurysms
US8795149 Nov 23, 2011 Aug 5, 2014 Theodore J. Lillehei Pneumatic or hydraulic cardiac assist devices
US9242098 Oct 30, 2013 Jan 26, 2016 The Charlotte-Mecklenburg Hospital Authority Devices, systems, and methods for treating cardiac arrhythmias
US20060200194 * Dec 23, 2005 Sep 7, 2006 Yun Anthony J Expandable vessel harness for treating vessel aneurysms
US20060211948 * Mar 18, 2005 Sep 21, 2006 International Business Machines Corporation Dynamic technique for fitting heart pacers to individuals
US20060287661 * Mar 1, 2006 Dec 21, 2006 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US20070100199 * Nov 3, 2005 May 3, 2007 Lilip Lau Apparatus and method of delivering biomaterial to the heart
US20080208275 * May 6, 2008 Aug 28, 2008 International Business Machines Corporation Dynamic technique for fitting heart pacers to individuals
US20100262220 * Apr 13, 2010 Oct 14, 2010 Anthony Joonkyoo Yun Expandable Vessel Harness for Treating Vessel Aneurysms
U.S. Classification 607/129, 600/37, 600/16
International Classification A61N1/375, A61N1/05
Cooperative Classification A61N1/0587, A61N1/0563, A61F2/2481, A61F2002/2484, A61N1/3756
European Classification A61F2/24W2, A61N1/05P
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LAU, LILIP;FISHLER, MATTHEW G.;MAR, CRAIG;REEL/FRAME:015067/0164;SIGNING DATES FROM 20040304 TO 20040305