Source: https://patents.google.com/patent/CN102647954B/en
Timestamp: 2019-09-15 17:21:05
Document Index: 208412219

Matched Legal Cases: ['§ 119', '§ 119', 'application No. 661', 'application No. 12', 'application No. 12', 'application No. 12', 'Application No. 11', 'application No. 11', 'application No. 11', 'application No. 11', 'application No. 12', 'Application No. 61', 'application No. 61', 'application No. 61', 'application No. 12', 'application No. 12', 'Application No. 12', 'application No. 12', 'application No. 12']

CN102647954B - A method of providing a system and method for a laser irradiation pattern of the eye lens - Google Patents
A method of providing a system and method for a laser irradiation pattern of the eye lens Download PDF
CN102647954B
CN102647954B CN201080042744.XA CN201080042744A CN102647954B CN 102647954 B CN102647954 B CN 102647954B CN 201080042744 A CN201080042744 A CN 201080042744A CN 102647954 B CN102647954 B CN 102647954B
CN201080042744.XA
CN102647954A (en
鲁道夫·W·费赖
斯蒂文·E·博特
加里·P·格雷
能斯雅有限公司
2010-07-23 Application filed by 能斯雅有限公司 filed Critical 能斯雅有限公司
2012-08-22 Publication of CN102647954A publication Critical patent/CN102647954A/en
2016-02-03 Publication of CN102647954B publication Critical patent/CN102647954B/en
本发明提供了一种开发激光系统的系统、装置和方法，该激光系统能创建精确的、预定的照射图案，以在眼睛晶状体中提供具有不同软化程度的区域。 The present invention provides a system, apparatus and method of developing a laser system, the laser system to create precise, predetermined illumination pattern to provide regions having different degrees of softening in the lens of the eye. 这些具有不同软化程度的区域可以具有如此的形状，其对应于从眼睛晶状体中除去其材料的所使用的装置。 These regions having different degrees of softening may have such a shape that corresponds to the apparatus employed to remove material from which the lens of the eye. 本发明还提供了一种具有多个球体的模式，其可以用于形成小泡，这些小泡又会润滑在剖切之后的晶状体材料的移出。 The present invention further provides a pattern having a plurality of spheres, which may be used to form vesicles were removed lens material will lubricate these vesicles after taken.
-种为眼睛晶状体提供激光照射图案的系统和方法 - kind of a system and method for a laser irradiation pattern of the eye lens
[000。 [000. 基于35U.SC § 119 (e) (1)，本申请要求如下的优先权：1)美国临时申请61/228, 560,名称为"一种为眼睛晶状体提供激光照射图案的系统和方法"，申请日期为2009年7月25日，W及2)美国临时申请661/228,529,名称为"一种为眼睛晶状体提供激光照射图案的系统和方法"，申请日期为2009年7月24日；并且本申请为下述两份申请的部分继续申请：1)美国专利申请12/217, 285,名称为"一种使用激光改善人眼晶状体调节幅度和增加人眼晶状体屈光力的系统和方法"，申请日期为2008年7月2日（正在申请中），该申请要求W申请日期为2007年1月19日的PCT/US2007/001353为优先权，W及2)美国专利申请12/217, 295,名称为"一种向眼睛晶状体投射激光束的系统和装置"，申请日期为2008年7月2日（正在申请中），该申请要求W申请日期为2007年1月19日的PCT/US2007/001486为优先权，其中美国专利申请第12/217, 285号为下述 Based 35U.SC § 119 (e) (1), this application claims priority to: 1) U.S. Provisional Application 61/228, 560, entitled "A method of providing a laser irradiation pattern of the eye lens system and method", filing date of July 25, 2009, W, and 2) U.S. provisional application No. 661 / 228,529, entitled "a method of providing a laser irradiation pattern of the eye lens system and method" filed date of July 24, 2009; and this application is a continuation in part application of the following two application: 1) U.S. Patent application No. 12/217, 285, entitled "a method of using a laser to improve the lens of the eye and increasing accommodative amplitude human system and method of the intraocular lens refractive power", filed dated July 2, 2008 (pending), which claims the W PCT filing date of January 19, 2007 of / US2007 / 001353 as a priority, and W 2) US Patent application No. 12/217, 295, name as "a projection lens of the eye to the beam of laser systems and devices" filing date of July 2, 2008 (pending), which claims the W PCT filing date of January 19, 2007 of / US2007 / 001,486 priority, which U.S. Patent application No. 12/217, 285 by the following 份申请的部分继续申请：1)美国专利申请11/414, 838,名称为"一种使用激光提供人眼晶状体形状结构弱化的系统和方法"，申请日期为2006年5月1日（正在申请中），该申请是美国专利申请11/337, 127、申请日期为2006年1月20日、名称为"一种治疗人眼晶状体结构的系统和方法"的部分继续申请（正在申请中），W及2)美国专利申请11/414, 819,名称为"一种治疗眼睛晶状体的系统和装置"，申请日期为2006年5月1日（正在申请中），该申请是美国专利申请11/337, 127、申请日期为2006年1月20日、名称为"一种治疗人眼晶状体结构的系统和方法"的部分继续申请（正在申请中）；其中，美国专利申请12/217, 295为下述两份申请的部分继续申请：1)美国专利申请11/414, 838,名称为"一种使用激光提供人眼晶状体形状结构弱化的系统和方法"，申请日期为2006年5月1日（正在申请中），该申请为 Applications for a continuation in part application: 1) US Patent Application No. 11/414, 838, entitled "A method of using a laser to provide a system and method of the human eye lens shape structural weakening of the" filing date of May 1, 2006 (pending in), the application is US Patent application No. 11/337, 127, filing date of January 20, 2006, entitled "system and method for treating eye lens structure" and a continuation in part application (pending), W and 2) US Patent application No. 11/414, 819, entitled "system and apparatus for treatment of the eye lens" date for applications is May 1, 2006 (pending), the application is US Patent application 11 / 337, 127, filing date of January 20, 2006, entitled "system and method for treating human eye lens construction of the" continuation in part application (pending); where US patent application 12/217, 295 part two of the following apply to continue to apply: 1) US Patent application No. 11/414, 838, entitled "a method of using a laser to provide a system and method of the human eye lens shape structural weakening of the" filing date of May 1, 2006 (pending), which applied for 国专利申请11/337, 127、名称为"一种治疗人眼晶状体结构的系统和方法"、申请日期为2006 年1月20日的部分继续申请（正在申请中），W及2)美国专利申请11/414, 819,名称为"一种治疗眼睛晶状体的系统和装置"，申请日期为2006年5月1日（正在申请中），该申请为美国专利申请11/337, 127、名称为"一种治疗人眼晶状体结构的系统和方法"、申请日期为2006年1月20日的部分继续申请（正在申请中）。 Patent Application 11/337, 127, entitled "System and method for treating human eye lens structure", as part of the filing date January 20, 2006 continuation application (pending), W and 2) United States Patent application 11/414, 819, entitled "system and apparatus for treatment of the eye lens" date for applications is May 1, 2006 (pending), the application of US patent application 11/337, 127, entitled "kind of person eye lens structure system and method of treatment", as part of the filing date January 20, 2006 continuation application (pending). W上申请的全部内容在此均作为参考。 Entire contents of the W are hereby incorporated by reference.
[0002] 本发明设及改善白内障、晶状体浑浊化、透明晶状体摘除、天然晶状体材料去除、 晶状体替换材料利用及其结合的方法和系统。 [0002] The method and system of the present invention to improve the design and cataract, lens opacification, clear lens extraction, removal of the natural lens material, lens replacement materials and bonded using. 本发明还设及提供预先确定的、精确的、可重复的激光照射图案（pattern,或称模式）的系统和方法，其可用于天然人眼晶状体中开创切口，运种发法和系统对于患者-患者和手术-手术是可重复的。 The present invention is also provided and provide a predetermined, precise and repeatable laser shot pattern (pattern, or said mode) system and method which can be used for the natural lens of the eye are created incision, transport kinds of, methods and systems for the patient - patients and surgery - surgery is repeatable.
[0003] 通常情况下，老花眼是调节振幅丧失导致的。 [0003] Typically, presbyopia is caused by the loss of modulation amplitude. 一般来说，白内障是晶状体内浑浊区域达到了影响视力的程度。 In general, the cataract is a cloudy area in the lens to achieve a degree of visual impact. 本发明所针对的其它症状包括但不限于晶状体浑浊化。 Other symptoms for which the present invention include, but are not limited to lens opacification.
[0004] 老花眼大部分表现为年龄在大约40至45岁时的近距离视力缺陷，特别是在昏暗的灯光下无法看清较小的字体。 [0004] Most of the performance of presbyopia near vision defects aged about 40-45 years of age, especially in dim light can not see the smaller font. 老花眼或随年龄增长而来的调节振幅衰减，与眼睛无法改变天然晶状体形状来适应远近不同的焦点有关系，而且其在45岁W上人群中发生的概率为100%。 Presbyopia comes with age or adjust the amplitude attenuation, has a relationship with the natural eye lens can not change shape to accommodate different focus distance, and the probability of its occurrence in the population aged 45 W to 100%. 据资料显示，在40-50岁期间，调节振幅随着年龄增长而稳定降低。 According to statistics, during the 40-50 years of age, adjusting the amplitude decreases steadily with age.
[0005] 白内障或天然晶状体变得不透明并出现视力暗淡的情况每年都发生在数W百万计的人群身上，其可W通过外科手术技术得到有效治疗，比如由凯尔曼化elman)在大约40 年前开创的超声波晶体乳化术。 [0005] or cataract the natural lens becomes opaque and appear dim vision scenarios count of people happened in a few million a year W, W which can be effectively treated by surgical techniques, such as the Kelman of elman) in approximately 40 years ago pioneered ultrasonic phacoemulsification. 虽然经过多年的改善，运些技术越来越精炼，但人们对眼外创伤安全问题的担扰，尤其是对需要用超声波能量来分割硬化白内障的角膜内皮，仍然是令人不放屯、的，特别是对于那些受损过的角膜内皮，比如那些患有富克斯氏营养不良症的患者。 Even after years of improvement, some transport technology becomes more refined, but people outside ocular trauma misgivings about security issues, especially the need for ultrasonic energy to split hardened cataract corneal endothelium, is still very tightly Tuen, the especially for those who had damage to the corneal endothelium, such as those patients with Fuchs's dystrophy.
[0006] 在使用激光治疗白内障的过程中出现了一些困难。 [0006] there have been some difficulties in the use of laser treatment of cataract procedure. 白内障会散射光线，包括激光光线，因此白内障会阻碍激光治疗达到期望的效果。 Cataract will scatter light, including laser light, so the laser treatment of cataract will hinder the desired effect. 此外，白内障和其它浑浊物的光线散射效果会使通过光学手段确定晶状体位置和形状变得困难。 Further, the light scattering effect of cataracts and other haze will determine the position and shape of the lens becomes difficult by optical means.
[0007] 目前已建立的白内障治疗方法是摘除已浑浊的人眼晶状体，置换植入人工晶状体(IOL)。 [0007] cataract treatment has been established that the removal of cloudy human lens, intraocular lens replacement implants (IOL). 一般来说，人工晶状体是由一个小塑料晶状体与被称为触觉的塑料侧支柱组成，支柱在眼内晶状体囊袋中固定晶状体于正确位置。 In general, the IOL is made of plastic with a small plastic side struts called haptics lens is composed of struts intraocular lens capsular bag lens is fixed in the correct position. 典范类型的人工晶状体包括单焦点晶状体、多焦点人工晶状体和调节型人工晶状体。 Model type comprises a monofocal IOL lens, multifocal intraocular lens and intraocular lens adjustment. 多焦点人工晶状体可W为患者在远近距离不同的情况下提供多焦点的视觉功能，调节型人工晶状体可W为患者提供视力调节功能。 W multifocal intraocular lens can provide the patient with multifocal near and far distances in different circumstances visual function, W may be adjusted IOL provides visual adjustment function for the patient. 许多人工晶状体都很有灵活性，可W被转入和/或折叠起来置入胶囊袋内。 Many IOL are flexibility, W can be transferred and / or folded into the capsule bag. 人工晶状体的实例有美国专利第7, 188, 949号、第6, 849, 091号、第5, 699, 142号和第5, 607, 472号，W上专利的披露内容在此均作为参考。 Examples of IOL are U.S. Patent No. 7, 188, 949, 6, 849 No. 091, 5, 699, 142 and 5, 607, No. 472, the W patent disclosures are hereby incorporated by reference . 举例来说，可能从本发明中受益的商业用人工晶状体有CRYSTALENS和ACRYS0FREST0R。 By way of example, may benefit from the present invention in commercial intraocular lens and has CRYSTALENS ACRYS0FREST0R.
[0008] CRYSTALENS人工晶状体是由Eyeonics研发、现由博±伦度ausch化omb)供应， 据信其中至少部分内容被认为披露于US6,849, 091中。 [0008] CRYSTALENS Eyeonics IOL is developed, is composed of Bo ± Lun degrees ausch OMB) supply, wherein it is believed that at least part of the contents is disclosed in US6,849, 091 in. 有关其结构和功效的更多信息由美国食品及药物管理局（FDA)记录于PMAP030002文件及其相关文件当中。 For more information about the structure and effect of records by the US Food and Drug Administration (FDA) in PMAP030002 file and its associated files among. FDA批准CRYSTALENS标明使用的部分："crystalensTM型号AT-45调节型人工晶状体专为眼内晶状体囊袋一期移植而设计，用于已摘除白内障晶状体的无晶状体成年患者视力矫正，为其提供近距离、中等距离和远距离的不戴眼镜视力。crystalensTM人工晶状体提供大约一个屈光度的单眼视力调节。"(2003年11月14日，PMAP030002,第二部分，安全性和有效性数据汇总，用途指示）。 FDA approved the use of part CRYSTALENS marked: "crystalensTM Model AT-45 designed for accommodating intraocular lens capsular an intraocular transplant designed for vision correction in adult patients who have cataract removal lens without lens, providing close , intermediate and distance vision without glasses .crystalensTM intraocular lens to provide a monocular vision about diopter adjustment. "(2003, November 14, PMAP030002, the second part, safety and efficacy data collection, use instructions) .
[0009] CRYSTALENS是FDA批准的调节型人工晶状体的例子。 [0009] CRYSTALENS accommodating intraocular lenses are examples of FDA approved. 术语"FDA批准的调节型人工晶状体"指所有获得FDA批准的且有标明用途为调节型的人工晶状体，不论该人工晶状体实际上是否用于该批准用途。 The term "FDA approved accommodating intraocular lens" refers to all approved by the FDA and is indicated use is regulated IOL, the IOL is actually whether the approval for use.
[0010] ACRYS0FREST0R人工晶状体由爱尔康（Alcon)供应，据信其中至少部分内容被认为披露于US5, 669, 142中。 [0010] ACRYS0FREST0R by the IOL Alcon (Alcon) supply, wherein it is believed that at least part of the contents is disclosed in US5, 669, 142 in. 有关其结构和功效的更多信息由美国食品及药物管理局（FDA)记录于PMAP040020文件及其相关文件当中。 For more information about the structure and effect of records by the US Food and Drug Administration (FDA) in PMAP040020 file and its associated files among. FDA批准RESTOR使用的部分： "AcrySOF®RESTOR®人工晶状体标明用于已摘除白内障晶状体的无晶状体且无老花眼成年患者二期视力矫正，为其提供近距离、中等距离和远距离的增强视力。本人工晶状体晶状体要求置于晶状体囊袋内。"（2004年4月24日，PMAP040020,第二部分，安全性和有效性数据汇总，指示）。 FDA approved the use of part RESTOR: "AcrySOF®RESTOR® intraocular lens has been marked for removal of cataract lens without lens and without presbyopia two adult patients with vision correction, to provide enhanced vision near, intermediate and distance of this. requirements placed intraocular lens lens lens capsule bag. "(April 24, 2004, PMAP040020, the second part, safety and efficacy data aggregation, indicating).
[0011] 因此，RESTOR是抑A批准用于近距离、中等距离和远距离视力人工晶状体的一个例子。 [0011] Thus, the RESTOR A is approved for suppressing an example of near, intermediate and distance vision IOL. 术语"抑A批准用于近距离、中等距离和远距离视力人工晶状体"指所有获得抑A批准且有标明用途为用于近距离、中等距离和远距离视力的人工晶状体，不论该人工晶状体实际上是否用于该批准用途。 The term "approved for inhibiting A near, intermediate and distance vision IOL" refers to all suppressors obtained approval A and the indicated use for intraocular lens near, intermediate and distance vision, regardless of the actual IOL on whether to approve the application. CRYSTALENS也是抑A批准用于近距离、中等距离和远距离视力人工晶状体的一个例子。 A CRYSTALENS also approved for suppressing an example of near, intermediate and distance vision IOL. 同时，RESTOR和CRYSTALENS也都是FDA批准的减少和/或消除戴镜需求的人工晶状体范例。 Meanwhile, RESTOR and CRYSTALENS are also FDA approved to reduce and / or eliminate the intraocular lens spectacles paradigm needs.
[0012] 图8为调节型人工晶状体CRYSTALENS示例形状和总体结构原理图。 [0012] FIG. 8 is a regulated CRYSTALENS exemplary IOL shape and overall configuration diagram. 该人工晶状体有晶状体结构202、邮邻晶状体结构20的较链203 2和接触晶状体囊袋201的触觉204。 The IOL 202 has a lens structure, the lens structure is ortho-mail chain 20 2 and the contact 203 of lens capsule 201 of the haptic pockets 204. 该人工晶状体的整体形状为非几何体。 The overall shape of the IOL non geometry. 此处术语"非几何体形状"是指除圆形、楠圆、方形和长方形之外的形状；术语"几何形状"是指圆形、楠圆、方形和长方形。 The term "non-geometric shape" means a shape other than circular, Nan round, square and rectangular; the term "geometry" refers to a circular, Nan round, square and rectangular.
[0013] 摘除天然晶状体与晶状体替代材料的置换都是利用眼睛边缘的第一道小切口完成，运是角膜和巩膜之间过渡区。 [0013] removal of the natural lens and replacing the lens replacement materials is the use of the eye incision edge of the first track is completed, the transport is a transition region between the cornea and sclera. 第一道切口通常是用一块小=角形刀身推过眼睛外角膜， 在摘除和置换天然晶状体过程中使用的其它仪器和材料也由此切口插入。 The first track is generally a small incision = pushed through outer angled blade cornea of ​​the eye, other instruments and materials used in the removal of the natural lens and replacement process are thus inserted into the incision. 同样也正是通过运道切口摘除天然晶状体并将晶状体替换材料置入眼睛。 It is also transported through the incisions and the removal of the natural lens into the eye lens replacement material.
[0014] 一旦有了第一道切口，已浑浊天然晶状体的摘除和晶状体替换材料（如抑A批准人工晶状体）的置入需要通过撕囊和/或囊切完成。 [0014] Once you have a first incision were removed opacified natural lens and lens replacement materials (e.g., suppressed approval A IOL) into the required capsulorhexis and / or completed by capsulotomy. 撕囊通常包括摘除部分晶状体前囊、 在晶状体囊内开孔或开穴，将导致至少部分撕裂动作。 Capsulorhexis generally comprises removal of the front portion of the lens capsule, the lens capsule open hole or opening, will result in at least partially tearing action. 囊切通常通过切除晶状体囊来完成， 不撕裂囊或W最低程度撕裂囊。 Capsulotomy is usually done by resection of the lens capsule, the capsule without tearing or W minimum tear sac. 因此，为了摘除已浑浊天然晶状体材料，切开晶状体囊。 Therefore, in order removal of the opacified natural lens material, cut the lens capsule. 现已有多种进行撕囊和囊切的技术。 There were now many capsulorhexis and a capsulotomy technique.
[0015] 运些撕囊技术的其中一种是开罐器法（canopenerapproach)。 [0015] Some transportation capsulorhexis technique wherein an opener is a method (canopenerapproach). 此方法使用一根小弯针在晶状体前囊周围开出一个小切口，在晶状体内开孔，通过运个孔摘除晶状体。 This method uses a small curved needle out of the balloon around a small incision in the lens opening, removal of the lens transport through a hole in the anterior lens. 此技术经常导致晶状体囊的边缘成为银齿形。 This technique often results in the edges of the lens capsule becomes silver tooth. 运些技术中的另一种是连续环形撕囊（CCC)。 These transport Another technique is a continuous curvilinear capsulorhexis (CCC). CCC 同样使用运一类型的小弯针来开始晶状体前囊的撕裂动作，然后用运根弯针和/或特殊的綴子，沿着切口边缘在晶状体囊内撕出一个圆孔。 CCC transported using the same type of small looper starts tearing operation of the anterior lens capsule, and then shipped root curved needle and / or the special sub-conjugated, along the cut edge of a circular tear in the lens capsule. 与开罐器法相比较而言，CCC减少了在开罐器法中使用开罐器技术而在晶状体内产生的银齿边缘。 For comparison with the opener wears, CCC reducing technology can opener opener process generated silver in the lens rim of teeth. 然而CCC不能消除不规则边缘形状的形成，而且运些不规则的出现取决于手术技巧和技术。 However, CCC can not eliminate the formation of irregularly shaped edges, and some irregular operation occurs depends on surgical techniques and technology.
[0016] 也可采用化go等离子刀在前囊开孔。 [0016] The plasma may also be of the knife go anterior capsule opening. 运种技术被称为囊切。 Yun kind of technology is called a capsulotomy. 化go等离子刀是一种手持设备，最初用于牙科。 Plasma go of the knife is a handheld device, originally used in dentistry. 它是一个将能量聚焦用于冲切丝状体的电磁装置。 It is an electromagnetic device for focusing the energy cut punch-like body. 更多关于化go 等离子刀的信息可参阅FDAPMAK063468、K001498、K041019、K050933 和US5,413,574。 For more information about the technology go plasma cutter can be found FDAPMAK063468, K001498, K041019, K050933 and US5,413,574.
[0018] 本发明提供了对天然人眼晶状体进行切口的新颖和改良的方法和系统，在运里天然人眼晶状体有时也指晶状体、天然晶状体、人眼晶状体和水晶晶状体，其包括了本发明的各个方面，并在本专利说明书中有详细阐述，从而可W更好地实现向眼睛晶状体提供激光光线、W更好地实现其它的方法和系统，如已公布的美国申请2007/173794A1、美国申请2007/173795A1、美国申请2007/185475A1、WO2007/084694A2 号（现美国申请号12/217,295)，W及WO2007/084627A2(现美国申请12/217,285)，W上申请的全部披露内容均在此均作为参考。 [0018] The present invention provides novel and improved method and system of the natural human lens be cut, in the operation in the natural human crystalline lens is sometimes referred to the lens, the natural lens, eye lens and crystal lens, which includes the present invention various aspects of, and in the present patent specification have elaborated, thereby providing better achieved W laser beam to the lens of the eye, W better implement other methods and systems, such as U.S. published application 2007 / 173794A1, U.S. application 2007 / 173795A1, US application 2007 / 185475A1, WO2007 / No. (now US application No. 12 / 217,295) 084694A2, W and WO2007 / 084627A2 (now US application 12 / 217,285), the entire disclosure of the application of the W are in this are Reference.
[0019] 此处提供了本发明的具体实施方式：一种向天然人眼晶状体提供激光照射图案的系统，W软化天然人眼，其包括：产生激光束的医用激光器；实施囊切的激光照射图案；激光照射图案具有剖切天然人眼晶状体的第一区域和第二区域，该激光照射图案的第一区域和第二区域有着不同的照射和/或剖切密度；在运种方式下，向人眼晶状体发送运种照射图案时，将导致晶状体形成对应于第一区域和第二区域的不同的柔软度和表观密度。 [0019] provided herein specific embodiments of the present invention: A system for providing a pattern of laser irradiation to the natural human crystalline lens, W softening the natural human eye, comprising: a medical laser generating a laser beam; a laser capsulotomy embodiment irradiation pattern; laser irradiation pattern has taken a natural human crystalline lens of the first and second regions, the first region and the second region of the laser irradiation pattern has a different illumination and / or cut density; in the transport ways, when the transmission pattern is irradiated to a human species transported intraocular lens will cause the lens is formed corresponding to the first and second regions of different softness and apparent density.
[0020] 此外，在该系统中，第一区域照射的数量可能比第二区域照射的数量密集，第二区域照射的数量也可能比第一区域照射的数量密集，而且照射图案可W进一步有开创一些体积形状（volumetricshape)的模式。 [0020] Further, in this system, the number of the first dense region may be irradiated with the irradiation than the second region, the number of the second region may be irradiated with intensive irradiation region than the first number, and the irradiation pattern may further have W Some create a bulk shape (volumetricshape) mode. 运些体积形状在第一区域可能比在第二区域密集，在第二区域的体积形状的数量也可能比在第一区域的密集。 These shapes may be transported volume ratio of density in the second area, the number of volumetric shapes may also be a second region in the first region than the density of the first region. 运些模式主要由诸如立方体和球体等体积形状组成。 These operation modes such as a cube and is mainly composed of an equal volume of a sphere composed of a shape.
[0021] 此外，在该系统中，第一区域的照射模式可能比第二区域的照射模式密集，第二区域的照射模式也可能比第一区域的照射模式密集，而且照射模式可W进一步有开创一些体积形状的模式。 [0021] Further, in this system, the irradiation pattern may be denser than the first region a second region of the irradiation pattern, the irradiation pattern of the second region may be denser than the first region of the irradiation pattern, and the illumination mode may further have W creating some of the volume of the shape model. 运些体积形状在第一区域可能比在第二区域的体积形状更加密集，第二区域的体积形状可能比第一区域的体积形状更加密集。 These shapes may be transported more dense than the volume of the volume of the shape of the second region in the first region, the shape of the volume of the second region may be more dense than the volume of the shape of the first region. 运些照射模式主要由诸如立方体和球体等大量体积形状组成。 These transport large volumes mainly by irradiation pattern shape such as a cube and a sphere and so on.
[0022] 本发明还提供了一种向天然人眼晶状体提供激光照射图案的方法，W软化天然人目艮，其包括：产生激光束的医用激光器；实施囊切的激光照射图案；激光照射图案具有剖切天然人眼晶状体的第一区域和第二区域，该激光照射图案的第一区域和第二区域有着不同的照射和/或剖切密度；在运种方式下，向人眼晶状体发送运种照射图案时，将导致晶状体形成对应于第一区域和第二区域的不同的柔软度和表观密度。 [0022] The present invention further provides a method of providing a laser irradiation pattern of the natural human lens, W softening native human eye Gen, comprising: generating a medical laser, a laser beam; embodiment capsulotomy laser shot pattern; laser irradiation pattern having a first cut native human eye lens and second regions, the first region and the second region of the laser irradiation pattern has a different illumination and / or cut density; in the transport ways, the transmission operation to a human crystalline lens when the irradiation pattern species, will result in the lens is formed corresponding to the first and second regions of different softness and apparent density.
[0023] 此外，在该方法中，第一区域的照射模式可能比第二区域的照射模式密集，第二区域的照射模式也可能比第一区域的照射模式密集，而且照射模式可W进一步有开创一些体积形状的模式。 [0023] Further, in this method, the irradiation pattern may be denser than the first region a second region of the irradiation pattern, the irradiation pattern of the second region may be denser than the first region of the irradiation pattern, and the illumination mode may further have W creating some of the volume of the shape model. 运些体积形状在第一区域可能比在第二区域的体积形状更加密集，第二区域的体积形状也可能比第一区域的体积形状更加密集。 These shapes may be transported more dense than the volume of the volume of the shape of the second region in the first region, the shape of the volume of the second region may also be more intensive than the volume of the shape of the first region. 运些照射图案主要由诸如立方体和球体等体积形状组成。 These transport mainly by the irradiation pattern such as a cube and a sphere shape composed of equal volume.
[0024] 此外，在该方法中，第一区域照射的数量可能比第二区域照射的数量密集，第二区域照射的数量也可能比第一区域照射的数量密集，而且照射图案可W进一步有开创一些体积形状的模式。 [0024] Further, in this method, the number density of the first region may be irradiated with the irradiation than the second region, the number of the second region may be irradiated with intensive irradiation region than the first number, and the irradiation pattern may further have W creating some of the volume of the shape model. 运些体积形状在第一区域可能比在第二区域的体积形状密集，在第二区域的体积形状的数量也可能比在第一区域的体积形状密集。 These shapes may be transported volume ratio of the volume of the shape of the second region in a first dense region, the number of the volume in the shape of the second region may also be denser than the volume of the first region in shape. 运些模式主要由诸如立方体和球体等体积形状组成。 These operation modes such as a cube and is mainly composed of an equal volume of a sphere composed of a shape.
[0025] 本发明还进一步提供了向天然人眼晶状体提供激光照射图案、W差别化地软化天然人眼晶状体的系统和方法，该系统包括：用于产生激光束的医用激光器；用于对天然人眼晶状体进行剖切的激光照射图案，其包括第一、第二和第=区域；每个区域主要由许多体积形状组成；至少两个区域具有不同密度的体积形状；运样在传送到天然人眼晶状体时， 至少有两个区域能够提供具有不同柔软度的晶状体区域。 [0025] The present invention further provides a laser irradiation pattern to provide the natural human lens, W softening system and method for differentiation of natural human lens, the system comprising: a laser for generating a medical laser beam; for natural human lens for irradiating laser cut pattern, which comprises a first, a second and a second region =; each region consisting mainly of a number of volumetric shapes; volumetric shapes having at least two regions of different density; sample transport to the transport of natural when the human lens, capable of providing at least two regions having different areas of the lens softness. 在该系统和方法中，任何一个体积形状的形状可能呈现为常用于从晶状体囊中摘除晶状体材料的吸出管或抽吸针的形状。 In the system and method, any shape may exhibit a volume shape conventionally used for removal of the lens shape of material from the lens capsule in draft tube or aspiration needle. 另外，至少有一个区域的形状是全部或部分地基于或者仿照运样的吸出管或抽吸针的形状。 Further, the shape of at least one region is totally or partially or modeled on the shape of the sample transport suction tube or needle aspiration.
[0026] 本发明还进一步提供了一种向天然人眼晶状体提供激光照射图案的系统和方法， 该系统包括一个用于产生激光束的激光器、一个与照射图案相关联的控制器。 [0026] The present invention further provides a system and method for providing a laser shot pattern to the natural human lens, the system comprising a laser for generating a laser beam, a controller associated with the irradiation pattern associated. 该照射图案包括一种模式，其可为人眼晶状体提供多样性的独立球体。 The illumination pattern comprises a pattern, which may provide a variety of human eye lens independent spheres. 因此，根据本发明的系统和方法，该照射图案可包括一种模式，其能提供至少5个沿着眼睛晶状体轴的独立球体；它还可能有一种能基本上在整个晶状体布满球体的模式；它也可能有一种发送照射的模式和序列，其能形成至少部分环绕球体的一层小泡。 Thus, the system and method of the present invention, the illumination pattern may include a pattern, which provides at least 5 along the axis of the lens of the eye independent sphere; it may also be able to have a full ball lens substantially the entire pattern ; it may also have a mode for transmitting the irradiation sequence and which can form a layer at least partially surrounding the ball vesicles. 此外，运一照射图案可W随之进一步与实施囊切的模式相关联。 Furthermore, W may be transported along a irradiation pattern associated with a further mode of embodiment capsulotomy.
[0027] 此外，本发明还设及一种在人眼中摘除天然人眼晶状体材料时提供润滑的方法和系统，该系统和方法包括W下过程和W下部件：一个提供激光束的激光器；一个与照射图案相关联的控制器；该照射图案包括一种能为人眼晶状体提供多个独立球体的模式；W及在该照射图案下，在人眼晶状体中定位照射，使得在发送激光束时也形成一层与其球体相关的小泡，从而并为球体的摘除提供润滑。 [0027] Further, the present invention is also provided, and one removal method and system for providing lubrication when the natural eye lens material in the human eye, the system and method include a process W and W at the lower part: a laser providing a laser beam; a the controller associated with the illumination pattern; the pattern comprises one illumination lens to the human eye can provide a plurality of separate spheres model; and W is irradiated in the pattern, positioning the lens of the eye is irradiated, so that the laser beam also when sending forming a layer of vesicle associated therewith a sphere, and thereby provide lubrication for the removal of the sphere.
[0028] 此外，本发明提供了一种用于剖切天然人眼晶状体的激光照射图案的系统和方法，W软化和润滑天然人眼晶状体的剖切面，该系统和方法包括：用于产生激光束的医用激光器；用于实施囊切的激光照射图案；用于对天然人眼晶状体进行剖切的激光照射图案； 该激光照射图案主要由大量的球体组成；该激光照射图案包括第一区域和第二区域；该激光照射图案第一区域的照射和/或剖切密度与该激光照射图案第二区域有所不同，使得该照射图案发送至人眼晶状体时，可产生经过软化和润滑的晶状体，W使摘除更为容易。 [0028] Further, the present invention provides a system and method for a laser irradiation pattern taken for the natural human lens, the cut plane W softening and lubricating the natural human crystalline lens, and the system comprising: means for generating a laser the medical laser beam; a laser capsulotomy embodiment irradiation pattern; means for the natural human lens to be taken laser shot pattern; the pattern of laser light irradiation is mainly composed of a large number of spheres; the laser irradiation pattern includes a first region and a second region; or the irradiation area of ​​the first pattern and the laser irradiation / density cut with the second laser irradiation region different patterns, so that the illumination pattern is transmitted to the human eye lens, the lens may produce softened and lubricated , W make removal easier.
[0029] 本发明还提供了一种向天然人眼晶状体提供激光照射图案的系统，其能差别化地软化天然人眼晶状体，该系统包括：用于产生激光束的医用激光器、用于对天然人眼晶状体进行剖切的激光照射图案，其包括第一和第二模式，第一模式包括能在晶状体中开创若干放射形切口（径向切口）的若干激光照射，第二模式包括能开创若干圆柱形切口的若干激光照射，其中，圆柱形切口同屯、地位于放射形切口的区域中。 [0029] The present invention further provides a system for providing a laser shot pattern to the natural human crystalline lens, which can soften the natural human lens differential, the system comprising: a medical laser for generating a laser beam for natural human lens for irradiating laser cut pattern comprising first and second modes, the first mode comprises a plurality of laser light irradiation can be to create a plurality of radial cuts (radial cut) in the crystalline lens, to create a second pattern comprising a plurality of energy Some laser irradiation cylindrical cut, wherein the cylindrical cut with village, located in the region of the radial cuts. 进一步地，第一模式可W有开创若干放射形切口的若干激光照射，运些放射形切口具有共同的圆屯、，第二模式可W有开创若干圆柱形切口的若干激光照射，圆柱形切口基本上为同轴，且基本上拥有共同的圆屯、。 Further, the first mode may have a plurality of W to create a plurality of laser irradiation radial cuts, some radial cuts transport a common circle having a second mode Tun ,, W laser radiation to create a plurality of several cylindrical cut, cylindrical cut substantially coaxial, and basically have a common circle Tuen. 其中，圆柱形切口可同屯、地位于放射形切口的区域，放射形的圆屯、与圆柱形的圆屯、一致。 Wherein, the cylindrical incision can be the same village, in the region of the radial cuts, the radial Tun circle, the circle of the cylindrical Tun consistent. 针对上述切口模式的改进是：在同轴的圆柱形切口的中央圆柱形中没有放射形切口。 Improvements to the cut mode: no radial cuts in the coaxial cylindrical cut in the central cylindrical. 运种切口模式的优点是消除了来自那些会在该模式中屯、或附近相交的放射形切口的高密度的激光照射。 Operation mode cut-species advantage is the elimination of high-density laser radiation from those in this mode will village, or near the intersection of radial cuts. 消除该中屯、区域的放射形切口又会阻止该模式中屯、的气泡产生，从而避免了角膜或视网膜区域暴露在大量的放射形激光束，改善了该模式的安全特性。 The elimination of the village, a radial cutout region will block the pattern village, bubble generation, thereby avoiding the area of ​​the retina or cornea security features is exposed in a large number of radial laser beam, to improve the model.
[0030] 本发明还提供了一种向天然人眼晶状体提供激光照射图案的系统，其能差别化地软化天然人眼晶状体，该系统包括：用于产生激光束的医用激光器、用于对天然人眼晶状体进行剖切的激光照射图案，其包括第一模式和第二模式；第一模式包括能在晶状体中开创若干放射形切口的若干激光照射；第二模式包括能开创若干圆柱形切口的若干激光照射。 [0030] The present invention further provides a system for providing a laser shot pattern to the natural human crystalline lens, which can soften the natural human lens differential, the system comprising: a medical laser for generating a laser beam for natural human lens for irradiating laser cut pattern comprising first and second modes; the first mode comprises a plurality of laser irradiation can create a plurality of radial cuts in the lens; the second mode includes a plurality of energy to create a cylindrical cut Some laser irradiation. 其中，圆柱形切口位于放射形切口的区域中。 Wherein the cylindrical incision in the region of the radial cuts.
[0031] 此外，本发明提供了用于天然人眼晶状体的激光照射图案的系统和方法，该系统包括或提供一个用于产生激光束的医用激光器；激光器具有与之相关联的控制器，该控制器具有与之相关联的激光照射图案；该激光照射图案包括能在人眼晶状体中提供若干截面为正方形或矩形的条棒的模式；发送或者能够发送照射图案到人眼晶状体。 [0031] Further, the present invention provides a system and method for a laser irradiation pattern of the natural lens of the human eye, the system comprising a medical or providing a laser for generating a laser beam; a laser having a controller associated therewith, which the controller has associated therewith a laser irradiation pattern; the pattern of laser irradiation comprising providing a plurality of square or rectangular cross-section of the bar pattern in the lens of the eye; or transmitting illumination pattern can be transmitted to the lens of the eye. 另外，在此提供的运些具体实施方式的照射图案可提供至少2个、至少3个、至少4个和至少5个基本上独立的条棒，其基本上为矩形或管状或两者的结合。 Further, the irradiation pattern transport these specific embodiments provided herein may provide at least 2, at least 3, at least 4 and at least 5 bar substantially independent, or substantially rectangular tubular or a combination of both . 作为一种选择方案，正方形或矩形截面的管是邻接的，使其可W形成在晶状体中占据中央体积的空间。 As an alternative, a square or rectangular cross section tubes are contiguous, W may be formed so as to occupy the center volume of the space in the lens.
[0032] 本领域的普通技术人员能够理解，基于本说明书和附图的提示，可W有多种具体实施方式W实现本发明。 [0032] Those of ordinary skill in the art will appreciate that the present specification and drawings based tips, there may be W W more embodiments of the present invention is implemented. 因而，本说明书中的具体实施方式并不W任何形式限制本发明的范围。 Thus, embodiments of the present specification does not limit the scope of W in any form of the invention.
[0033] 图1是询J切和摘除晶状体材料之照射图案的不意图。 [0033] FIG. 1 is a cut and removing J inquiry not intended illumination pattern of the lens material.
[0034] 图2是剖切和摘除晶状体材料之照射图案的示意图。 [0034] FIG. 2 is a sectional and schematic view of the illumination pattern of lens material removed.
[0035] 图3是询J切和摘除晶状体材料之照射图案的不意图。 [0035] FIG. 3 is cut and removed inquiry J illumination pattern of the lens material is not intended.
[0036] 图4是晶状体材料摘除=种类型抽吸针的照射图案的截面图。 [0036] FIG. 4 is a sectional view of the irradiation pattern = kind type of lens material removed aspiration needle.
[0037] 图5是剖切和摘除晶状体材料之照射图案的示意图。 [0037] FIG. 5 is a sectional and schematic view of the illumination pattern of lens material removed.
[003引图6A和6B是晶状体的平面图和剖面图，其显示了多球的照射图案。 [003 cited Figures 6A and 6B are a plan view and a sectional view of the lens showing the illumination pattern of multiple balls.
[0039] 图6C是图6A和她模式中部分球的不意图。 [0039] FIGS. 6A and FIG. 6C is her mode of the sphere is not intended.
[0040] 图7是一种向人眼晶状体发送如图1-3、5、9和11、17所示的激光束照射图案的系统的示意图。 [0040] FIG. 7 is a schematic of a system of laser beam irradiation pattern shown in FIG 1-3,5,9 and 11, 17 to transmit the human crystalline lens.
[0041] 图8是调节型人工晶状体的示意图。 [0041] FIG. 8 is a schematic diagram accommodating intraocular lens.
[0042] 图9是显示位于与图8中调节型人工晶状体相关的人眼晶状体照射图案的示意图。 [0042] FIG. 9 is a schematic diagram related to the regulation positioned IOLs in the eye lens 8 of FIG display illumination pattern.
[0043] 图IOA-D是带状剖切环形囊切的示意图。 [0043] FIG IOA-D are schematic sectional annular strip capsulotomy.
[0044] 图11-12是放射形、球形图案和其结合的照射图案的示意图。 [0044] Figures 11-12 are schematic radial spherical pattern, and having a combined illumination pattern.
[004引图13A-C是激光照射图案的示意图。 [004 primer FIGS 13A-C is a schematic diagram of a laser irradiation pattern.
[0046] 图14A-C是激光照射图案的不意图。 [0046] FIGS 14A-C are not intended to laser irradiation pattern.
[0047] 图15A是激光照射图案的示意图。 [0047] FIG. 15A is a schematic diagram of a laser irradiation pattern.
[0048] 图16A是激光照射图案的示意图。 [0048] FIG. 16A is a schematic diagram of a laser irradiation pattern.
[0049] 图17A是激光照射图案的示意图。 [0049] FIG. 17A is a schematic diagram of a laser irradiation pattern.
[0050]总之，本发明设及向人眼晶状体提供激光的方法和系统，来改善与天然晶状体摘除和晶状体材料置换有关的过程，尤其是与白内障手术相关的系统和方法的改进。 [0050] In summary, the present invention is to provide a laser set up and the eye lens system and a method to improve the removal of the natural lens and replacement processes related to the lens material, particularly associated with cataract surgery to improve systems and methods. 特别是， 本发明设及向天然人眼晶状体提供预定的激光照射图案的方法与系统，运些照射图案具有不同的照射和剖切密度。 In particular, the present invention is provided, and provide a predetermined laser shot pattern to the natural human crystalline lens method and system, these transport irradiation pattern having different illumination and cut density. 运些照射图案发送到晶状体时，造成晶状体材料软化，更容易从囊中摘除。 These irradiation pattern when the operation is sent to the lens, resulting in softening of the lens material, easier removal from the bladder. 因此，本发明提供了在白内障手术中摘除晶状体材料特定部分时可定制、可预先确定的所需力的相对量。 Accordingly, the present invention provides a customizable removed when a specific portion of the lens material in cataract surgery, the relative amount of force required may be determined in advance.
[0051] 本发明的方法和系统可W应用于此处列出的共同待决专利申请中的新颖创新的激光系统技术，运些申请在此均可作为参考；本发明的方法和系统也可能应用于其它的、将来开发的用于摘除晶状体材料的激光发送系统。 Laser SYSTEM [0051] The method and system of the present invention may be applied to W listed here co-pending patent application, a new innovation, some transport can hereby incorporated by reference; the method and system of the present invention may also applied to other, developed in the future for the removal of laser transmission system lens material. 优选地，本发明的方法和系统可被吸收纳入并应用于此处作为参考所列的共同待决申请系统。 Preferably, the method and system of the present invention may be applied to and absorbed incorporated herein by reference as set forth in co-pending application system. 运种情况下，一个单一的系统与一个单一的医用激光器，可W作为一种在摘除和置换天然晶状体实施过程中从开始应用到结束的必要剖切装置。 Downward case, a single system with a single medical lasers, W may be taken as a necessary means to apply the process from the beginning end of the removal and replacement of the natural lens embodiment.
[0052] 应用于晶状体材料摘除和转换的新颖性和开创性激光系统和方法在美国临时和常规专利申请中披露的有：申请号61/228, 506,名称：实施线银囊切的系统和方法（代理人申请案编号：12212/44);申请号61/228, 484,名称：实施和密封眼睛边缘区域切口的系统和方法（代理人申请案编号：12212/48);申请号61/228, 514,名称：实施矫正眼睛弧形切口的系统和方法（代理人申请案编号：12212/49) ;W及申请号12/509, 412,名称：从人眼晶状体摘除和置换晶状体材料的方法和系统（代理人申请案编号：12212/51) ;W及申请号12/509, 211，名称：为激光晶状体规程创造小泡护罩的方法和系统（代理人申请案编号： 12212/54)。 [0052] The novel and applied to a system and method for laser groundbreaking lens material removal and conversion disclosed in U.S. provisional and regular patent applications are: Application No. 61/228, 506, entitled: Silver embodiment capsulotomy line system and method (Attorney Docket No.: 12212/44); application No. 61/228, 484, entitled: system and method of sealing the cut edge region of the eye (Attorney Docket No.: 12212/48); application No. 61 / 228, 514, entitled: system and method embodiments (Attorney Docket No.: 12212/49) correcting eye arcuate incision; W is and application No. 12/509, 412, entitled: lens removal from the eye and replacement of the lens material a method and system (Attorney Docket No.: 12212/51); W and application No. 12/509, 211, entitled: method to create vesicles shroud procedures and laser lens system (Attorney Docket No.: 12212/54 ). 运些申请提交于2009年7月24日，每件申请的全部内容在此均可作为参考。 These shipped filed July 24, 2009, the entire contents of each are hereby incorporated by reference are available.
[0053] 因此，本发明提供了一种晶状体结构改造的系统和方法，使其更容易摘除而且通过减少和/或消除在超声乳化中使用的高频超声波能量的需求可能增加手术的安全性。 [0053] Accordingly, the present invention provides a system and method for transformation lens construction, and to make it easier removal may increase the security of the operation by reducing and / or eliminating the high-frequency ultrasonic energy used in phacoemulsification needs. 总之，在特定体积形状模式中使用光致破裂剖切来创建切片晶状体，即将晶状体切开成为分段的体积形状。 In summary, the use of photodisruption to create a slice taken at a particular volume shape lens mode, i.e. lensectomies be segmented volumetric shapes. 此外，能够放置在眼睛晶状体内的运些体积形状的大小、形状和分布情况应通过创建不同密度、表观密度、或柔软度的区域来完成，运些区域可能有着不同的和已预先确定的形状。 Further, the lens of the eye can be placed in the transport some size, shape and distribution of the volume of the shape to be created by a different density, the apparent density, softness or regions to complete, these areas may have different operation and has been determined beforehand shape.
[0054] 此处使用的晶状体变得柔软或者软化时，当晶状体变得更容易从晶状体囊中摘除时，只需要更少的力量和精力就可W完成摘除。 When [0054] As used herein, the lens becomes soft or softened, when the lens becomes more easily removed from the lens capsule, requires less power and energy W can be completed removed. 因此，此处所披露的内容是，晶状体会在与给定照射密度和/或给定切割密度的激光相互作用之后变软。 Accordingly, the disclosure of which is here, and a given lens will irradiation density and / or density of a laser cutting after a given interaction softened. 因此，治疗区域的柔软度会随着切割密度的增加而增加。 Therefore, the treatment area of ​​softness increases with the cutting density increases. 相似地，随着柔软度的增加，摘除晶状体所需花费的力量和精力减少。 Similarly, with the increasing softness, strength and energy required for removal of the lens to reduce cost. 在通常情况下，如果使用相似形状切割和模式，拥有更大照射密度的模式和更大切割数量的模式会导致晶状体柔软度增加幅度的上升，完成摘除所需要的力量和精力则更少。 Under normal circumstances, if the pattern of similar shape and cut, have a greater density of the irradiation mode and a cutting mode causes a greater number of the lens to increase the softness rise to complete removal of power and energy required is less.
[0055] 运些区域的形状可W变换，W配合用于从囊中摘除晶状体材料的抽吸针顶端的形状，不管是否为超声乳化性。 [0055] The shape of these regions may be transport transformation W, W shape for fitting the withdrawal spike tip lens material is removed from the bladder, regardless of whether the phacoemulsification. 通常，运些针的顶端都有一定角度，47°、30°或0°。 Typically, these transport needle tip has a certain angle, 47 °, 30 ° or 0 °. 运些顶端的示意图分别可见图4中的顶端47、30和0。 These are transported to the top schematic top visible in FIGS. 4 and 0 47,30.
[0056] 图1为提供不同密度区域的照射图案。 [0056] FIG 1 to provide a different illumination pattern density region. 由此，我们可W看到一个天然人眼晶状体的平面示意图，图上晶状体有晶状体囊1和水分离区2。 Thus, we can see W plan view of a natural human lens, the lens has a lens capsule of FIG. 1 and the water separation zone 2. 该实施例中有不同照射密度（照射密度）的S个区域，第一块区域3、第二区域4和第S区域5。 In this embodiment there are different irradiation density (irradiation density) of the S regions, a first region 3 and second region 4 and region 5 S.
[0057] 此处提供了一个不同的照射和/或剖切密度的第一区域3。 [0057] Here provides a different illumination and / or the density of the first region 3 cut. 运一不同密度的区域通过切割晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 To form a transport region becomes different densities by cutting the lens shapes of various volumes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第一区域内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）较低。 These transport volume density of the shape in the first region (W thereof and means for forming cut and laser irradiation) is low.
[005引此处提供了一个不同的照射和/或剖切密度的第二区域4。 [005 cited herein provides a different illumination and / or the density of the second region 4 cut. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第二区域内的运些体积形状可能与第一区域内的体积形状相同或有所不同。 These shapes within transport volume of the second region may be the same or different from the shape of the inner volume of the first region. 第二区域4内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第一区域3内的体积形状的密度大。 These shapes transport volume density in the second region 4 (W thereof and means for forming cut and laser irradiation) is larger than the density of the shape of the inner volume of the first region 3.
[0059] 此处提供了一个不同的照射和/或剖切密度的第S区域5。 [0059] Here we provide a different illumination and / or the 5 S region cut density. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第=区域内的运些体积形状可能与第一区域内的体积形状和第二区域内的体积形状相同或有所不同。 Op = volume of some of the shape of the inner volume of the shape of the area may be the first area and the same shape or different volumes in the second region. 第=区域5内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第二区域4内的体积形状的密度大。 = Density of the transported volume of some shape in the area 5 (W thereof and means for forming cut and laser irradiation) is larger than the volume of the second region 4 in the shape of the density.
[0060] 因此，在图I中有S种不同照射和剖切密度的照射图案，当应用于人眼晶状体时， 运些照射图案会导致=个对应具有如前所述不同形状和柔软度的晶状体区域。 [0060] Thus, there are S different density of the irradiation and the irradiation pattern cut in Figure I, when applied to the human lens, the illumination pattern can cause some transport = correspond with a different shape as described above and softness lens area.
[0061] 图2为提供不同照射和/或剖切密度区域的照射图案。 [0061] FIG 2 to provide different illumination and / or illumination pattern density region of cut. 由此，我们可W看到一个天然人眼晶状体的平面示意图，图上晶状体有晶状体囊6和水分离区7。 Thus, we can see W plan view of a natural human lens, the lens has a lens capsule of FIG water separation zone 6 and 7. 该实施例中有不同照射密度的=个区域，第一区域8,第二区域9和第=区域10。 In this embodiment there are different = irradiation density regions, the first region 8, 9 of the second region and the second region 10 =.
[0062] 此处提供了一个不同的照射和/或剖切密度的第一区域8。 [0062] Here provides a different illumination and / or the density of the first region cut 8. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第一区域内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）较低。 These transport volume density of the shape in the first region (W thereof and means for forming cut and laser irradiation) is low.
[0063] 此处提供了一个不同的照射和/或剖切密度的第二区域9。 [0063] Here provides a different illumination and / or second cut-density region 9. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第二区域内的运些体积形状可能与第一区域8内的体积形状相同或有所不同。 These shapes within transport volume of the second region may be the same or different from the shape of the inner volume 8 of the first region. 第二区域9内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第一区域10内的体积形状的密度大。 These shapes transport volume density in the second region 9 (W thereof and means for forming cut and laser irradiation) is greater than the density of the shape of the inner volume of the first region 10.
[0064] 此处提供了一个不同的照射和/或剖切密度的第S区域10。 [0064] Here provides a different illumination and / or density of the cut area S 10. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第=区域内的运些体积形状可能与第一区域内的体积形状和第二区域内的体积形状相同或有所不同。 Op = volume of some of the shape of the inner volume of the shape of the area may be the first area and the same shape or different volumes in the second region. 第=区域10内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第二区域9内的体积形状的密度大。 These volume density run = shapes in the first region 10 (W thereof and means for forming cut and laser irradiation) is larger than the volume of the shape of the density in the second region 9. 因此，第=区域10中晶状体的表观密度将低于第二区域9中晶状体的表观密度，反过来，第二区域9中晶状体的表观密度将低于第一区域8中晶状体的表观密度，而反过来，第一区域的表观密度将低于切片前晶状体中的表观密度。 Thus, an apparent density = area of ​​lens 10 will be lower than the apparent density of the second lens region 9, in turn, the apparent density of the second lens 9 in the region below the first region of the lens 8 in table apparent density, in turn, the apparent density of the first region is less than the apparent density of the sections in front of the lens.
[0065] 对于此处使用的在某区域不同密度下切片后晶状体表观密度，较低表观密度晶状体区域对应于较软和较易抽吸的材料，而较高表观密度晶状体区域对应于较坚硬和较难抽吸的材料。 [0065] For the apparent density of the lens sections, the lens region corresponding to a lower apparent density used herein in different densities in a region of relatively soft material easily sucked, and higher apparent density region corresponding to the lens Tougher and more difficult suction materials. 对于此处使用的不同密度的区域，术语第一、第二和第=的使用是针对特定模式密度的关联术语，并非指代运些模式在晶状体上排列的先后序数顺序。 Regions of different densities for use herein, the first, the second and the first use of the term = term for a specific mode is associated with the density, does not refer to the order of ordinal number has transportation of these modes are arranged on the lens. 另外，此处使用的术语区域指代并包括=维，即体积形状。 Further, the term area as used herein refers to and includes = dimension, i.e. volume shape.
[0066] 图3为提供不同照射和/或剖切密度区域的照射图案。 [0066] Figure 3 to provide different illumination and / or illumination pattern density region of cut. 由此，我们可W看到一个天然人眼晶状体的平面示意图，图上晶状体有晶状体囊11和水分离区12。 Thus, we can see W plan view of a natural human lens, the lens has a lens capsule of FIG. 11 and the water separation zone 12. 该实施例中有不同照射密度的两个区域，第一区域13和第二区域14。 In this embodiment there are two different irradiation density regions, the first region 13 and second region 14.
[0067] 此处提供了一个不同的照射和/或剖切密度的第一区域13。 [0067] Here provides a different illumination and / or the density of the first region 13 cut. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第一区域内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）较低。 These transport volume density of the shape in the first region (W thereof and means for forming cut and laser irradiation) is low.
[006引此处提供了一个不同的照射和/或剖切密度的第二区域14。 [006 cited herein provides a different illumination and / or second cut-density region 14. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第二区域内的运些体积形状可能与第一区域内的体积形状相同或有所不同。 These shapes within transport volume of the second region may be the same or different from the shape of the inner volume of the first region. 第二区域14内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第一区域13内的体积形状的密度大。 These shapes transport volume density in the second region 14 (W thereof and means for forming cut and laser irradiation) is larger than the volume of the first region 13 in the shape of the density.
[006引图5为提供不同照射和/或剖切密度区域的照射图案，在运一模式中，最高照射和/或剖切密度区域的形状对应呈现47°吸引管的形状。 [006] Figure 5 is incorporated to provide different illumination and / or illumination pattern cut density region, in a transport mode, the maximum irradiation and / or cut density region corresponding to the shape of the suction tube assumes the shape of 47 °. 由此，我们可W看到一个天然人眼晶状体的平面示意图，图上晶状体有晶状体囊16和水分离区16。 Thus, we can see W plan view of a natural human lens, the lens has a lens capsule of FIG. 16 and the water separation zone 16. 该实施例中有不同照射密度的两个区域，第一区域17和第二区域18。 In this embodiment there are two different irradiation density regions, the first region 17 and second region 18.
[0070] 此处提供了一个不同的照射和/或剖切密度的第一区域17。 [0070] Here provides a different illumination and / or the density of the first region 17 of the cut. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 第一区域内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）较低。 These transport volume density of the shape in the first region (W thereof and means for forming cut and laser irradiation) is low.
[0071] 此处提供了一个不同的照射和/或剖切密度17的第一区域。 [0071] provided herein and / or density of the first region 17 is cut a different illumination. 运一不同密度的区域通过剖切晶状体成为各种体积形状而形成，如立方体、球体、锥形、条形等，球体在本说明书中有更详细的阐述。 Transport a different density regions is formed by a cut lens into volumetric shapes, such as cubes, spheres, cones, rods, and the like, the sphere set forth in more detail in this specification. 不同密度的运一区域的形状对应呈现为47°吸引管或抽吸针，如图4管状47。 Transport a shape corresponding regions of different densities is presented suction tube 47 ° or aspiration needle, the tubular 47 in FIG. 4. 第二区域内的运些体积形状可能与第一区域内的体积形状相同或有所不同。 These shapes within transport volume of the second region may be the same or different from the shape of the inner volume of the first region. 第二区域18内的运些体积形状的密度（W及用于形成它们的激光照射和剖切）比第一区域17内的体积形状的密度大。 These shapes transport volume density in the second region 18 (W thereof and means for forming cut and laser irradiation) is larger than the volume of the first region 17 in the shape of the density. 因此，应用第二照射图案的会比第一区域的晶状体柔软。 Thus, application of the second illumination pattern will be softer than the first region of the lens. 运样便为运两个模式的应用创造出了软化的晶状体，使得吸引管或抽吸针的最初插入更加方便、更加安全、也更少创伤。 The sample transport will create two modes of operation for the application of a softening of the lens, so that the suction tube or needle aspiration of initial insertion easier, safer and less traumatic. 相应地，通过先从区域18抽吸材料，之后医生可W将吸引管顶端放至区域17W支撑并/或更好地接触区域17,进一步辅助操作晶状体的摘除。 Accordingly, by starting with material suction region 18, the physician can then W to the suction region of the discharge tube to the top support 17W and / or better contact region 17, to further assist lens removal operation.
[0072] 图5为区域18的示意图，对应于47D吸引管形状47 (图4)，须知此形状也与其它目前使用的吸引管相对应，如图4中目前吸引管形状（图中形状47显示了47°吸引管的形状，形状30显示了30°吸引管的形状，形状0显示了0°吸引管的形状），或者与未来发展出的形状相对应。 [0072] FIG. 5 is a schematic diagram of the region 18, 47D corresponding to the shape of the suction tube 47 (FIG. 4), this shape also notes with other corresponding suction tube currently in use, as shown in the current shape of the suction tube (47 shaped figure shows the shape of the suction 47 °, the shape of the display 30 corresponding to the shape of the suction 30 °, 0 shows the shape of suction tube shape), or the shape and future development 0 °.
[0073] 图6A和图6B为照射图案。 [0073] FIGS. 6A and 6B illumination pattern. 图6A为多样性球体照射图案的人眼晶状体平面图， 图6B为同一多样性球体照射图案的人眼晶状体截面图。 6A is a spherical lens of the eye illumination pattern diversity plan view, FIG. 6B is a sectional view of the lens of the eye ball of the same illumination pattern diversity. 图6A和图6B通过示例不限于说明于晶状体的一个模式，该模式将切开晶状体，因此，基本上所有的晶状体都会充满独立的球体。 6A and 6B illustrate by way of example to the lens is not limited to a mode that will cut the lens, and therefore, substantially all of the lens are filled with a separate sphere. 虽然未作图示，运一照射图案可用于水解区。 Although not illustrated, the illumination pattern may be used to transport a hydrolysis zone. 此处提供了晶状体囊21和具有多个球体的激光照射图案22,包括若干独立球体图案23,（仅有部分球体23有编号，即23曰，23b， 23c，23d和23e，W避免图形混淆）球体互相之间不接触，通过晶状体材料隔开。 Provided herein lens capsule 21 and the laser irradiation pattern having a plurality of spheres 22, 23 includes a plurality of independent spherical pattern, (numbered only a partial sphere 23, said i.e. 23, 23b, 23c, 23d and 23e, W avoid confusion pattern ) do not contact each other between the spheres, separated by the lens material.
[0074] 在本特定具体实施方式中，球体的大小要能够沿晶状体y轴摆放6个球体。 [0074] In this particular embodiment, the size of the sphere to be able to put the ball 6 along the y-axis of the lens. 如果球体之间有空间余留，并且有足够数量的球体剖切晶状体W软化晶状体利于摘除，则球体的大小可能会有所变化。 If there is space remaining, and a sufficient number of balls to soften the lens cut lens W conducive removed between the ball, the ball's size may vary.
[00巧]在人眼晶状体中创造运些球体会引起小泡的形成。 [00 clever] in the lens of the eye in the sphere to create some luck cause the formation of vesicles. 运些小泡会与球体关联在一起，理论上讲，它们可能出现在球体周围，即球体的表面上，成为摘除时球体进入抽吸针的润滑剂。 Operation will be associated with some small bubbles with the ball, in theory, they may appear around the sphere, i.e., on the surface of the sphere, the sphere becomes a lubricant into the suction needle during removal. 图6C为小泡层的示意图。 6C is a schematic diagram vesicles layer. 图中显示的球体有23曰，236,23(：，来自图64和图68中显示的若干球体。运些球体各自都有小泡层并分别与24a，24b和24c相关联。运些小泡层可由未联合的单个小泡组成，也可由已联合成膜的小泡组成，或由两者的组合组成。 Figure 23 shows said sphere, 236,23 (:, from several spheres 64 and 68 shown in FIG. Spheres each have some transport vesicles and each layer 24a, 24b and 24c being associated with some small bubbles transport a single blister layer may be composed of non-union, or by forming vesicles have been combined, or of a combination of both components.
[0076] 此处，就所披露的多数照射图案而言，激光照射的顺序可按照从后方到前方执行， 要获得更多可预测的结果，则需要减少由穿过气泡的照射导致的变化。 [0076] Here, it is most terms disclosed illumination pattern, the laser irradiation order from the rear to the front can be performed in accordance with, to more predictable results obtained, it is necessary to reduce the variation by the irradiation through the bubble caused. 然而，在两个不合需要的效果之间，要选择较轻的情况，可能需要从前方到后方来照射白内障。 However, between the two undesirable effects, to choose lighter, the cataract may need to be illuminated from the front to the rear. 因此，比起射穿白内障组织，射穿气泡或者使其消散可能更加有利，因为射穿白内障组织会带来更加严重的散射光，比起气泡干扰会更加迅速地防止光致破裂。 Thus, compared to penetrate the cataract tissue to penetrate or bubbles dissipate it may be more advantageous, because of cataract tissue penetrate more serious will bring the scattered light, than the bubble interference can be prevented more rapidly photodisruption. 因此，在此提出首先光爆破白内障的最前端部分，然后向后方移动，射穿白内障组织的气泡残留，然后到下一层白内障组织。 Thus, in this first proposed photodisruption foremost part of cataract, and then moved rearward, air bubbles remain cataract penetrate tissue, and then to the next layer of cataract tissue. 除了在前部Z位面进行激光照射后向后部移动，再进一步向下钻深，从前部至后部，此处即为Z轴及移至x/y，然后再次向下。 In addition to the front portion Z plane after the laser irradiation portion moves rearward, and then further downward drilling depth, from the front to the rear, that is, where the Z-axis and moved x / y, then down again. 运些照射图案也可应用于透明晶状体，随后该晶状体也会被摘除。 These transport the irradiation pattern may be applied to a transparent lens, then the lens will be removed. 当处理透明晶状体时，应用从后部到前部的照射是合适的。 When the transparent lens processing, applied from the rear to the front portion of the irradiation is suitable.
[0077] 图7为通常优选的激光系统的示例，即用于治疗患者的激光装置。 [0077] FIG. 7 is a generally preferred exemplary laser system, i.e., a laser device for treating a patient. 该系统包括医用激光器101 ;用于传送激光束104的光学系统102 ;用于W特定模式103向晶状体传送激光束的控制系统104 ;控制系统103与系统的其它组件相关联和/或连接，如图7中虚线示例，和/或其它未在图7中显示的控制系统。 The system comprises a medical laser 101; 104 for transmitting a laser beam optical system 102; W-specific mode for transmission control system 103 of the laser beam 104 to the lens; the other components of the control system 103 associated with the system and / or connection, such as the broken line in the example of Figure 7, and / or other control systems not shown in FIG.
[0078] 图7为通常情况下通过在晶状体中开创激光切口W提供天然人眼晶状体软化的激光系统的参照实例，医用激光器101应提供能通过角膜的波长的光束104、房水和晶状体。 [0078] Figure 7 provides an example of a laser system with reference to the natural human crystalline lens created by laser cuts softened W typically in the lens case, the medical laser 101 provides a beam 104 can be wavelength cornea, lens, and aqueous humor. 该光束应为短脉冲宽度，加上能量和光束尺寸，产生光致破裂。 The beam should be a short pulse width, together with the energy and beam size, generating photodisruption. 因此，此处使用的术语激光照射或照射指的是被传送至某一位置的激光束脉冲，并在该位置引发光致破裂。 Accordingly, the term laser irradiation or irradiation as used herein refers to a laser beam pulse is transmitted to a location, and cause photodisruption in this position. 此处使用的术语光致破裂本质上是指在激光束焦点创造一个微小的冲击波并用激光将物质转换为气体。 The terminology used herein the photodisruption essentially refers to the focal point of the laser beam and creating a shock wave with a small laser beam to convert the material gas. 术语光致破裂还通常伴随着激光诱导光学击穿化I0B)。 The term photodisruption also usually accompanied by laser induced optical breakdown of I0B). 特别是，采用约为300 纳米至2500纳米之间的波长时。 In particular, when using a wavelength between about 300 nanometers to 2500 nanometers. 脉冲宽度从1飞秒到100皮秒之间均可采用。 Femtosecond pulse width from 1 to 100 picoseconds can be used. 能量从1 纳焦耳到1毫焦耳均可采用。 Energy from 1 nanojoule to 1 millijoules may be used. 脉冲率（也称为脉冲重复频率（PRF)，计算单位为赫兹脉冲每秒）可能会在1千赫至几兆赫之间。 Pulse rate (also referred to as the pulse repetition frequency (PRF), the unit of hertz pulses per second) may be between 1 kilohertz to several megahertz. 一般来说，在商业激光设备中，较低的脉冲频率对应较高的脉冲能量。 In general, in a commercial laser device, the lower the pulse frequency corresponding to the higher pulse energy. 各式各样的激光类型可能被用于眼睛组织的光致破裂，依赖于脉冲宽度和能量密度。 Variety of types may be used for laser photodisruption ocular tissue, depending on the pulse width and energy density. 因此，运类型的激光器披露于2007/084627A2和W02007/084694 (现美国申请第12/217, 285号），W上各申请的全部内容在此均作为参考。 Therefore, transport types of lasers disclosed in 2007 / 084627A2 and W02007 / 084694 (now US Application No. 12/217, 285), the entire contents of each application on W are hereby incorporated by reference. 运些激光器和其它类似的激光器可W作为医用激光器使用。 These transport lasers and other similar lasers may be used as a medical W laser.
[0079] -般来说，向人眼结构包括天然人眼晶状体传送激光束104的光学系统102应该有能力W精确且预先确定的模式从x，y和Z=个维度向天然晶状体提供一连串照射。 [0079] - In general, the human eye structure comprises natural human crystalline lens 104 of the transmitted laser beam optical system 102 should be able to accurately and W a predetermined pattern to provide a series of illuminated from x, y and Z = the natural lens dimensions . 此处使用的Z维是指相对应于或者本质上与人眼光学（A巧轴相平行的那条轴的维度。该光学系统还应提供一个预先确定的光束照射大小同传送至天然晶状体或其它需要被切除的眼睛结构的激光能量共同作用来引起光致破裂。 Herein refers Z dimension corresponds to the human-eye, or (dimension A clever piece shaft essentially parallel to the axis. The optical system should also provide a pre-determined size of the beam irradiation with the natural lens or to transmit other laser energy to be cut eye structure interaction due to photodisruption.
[0080] -般来说，传送激光束104的控制系统103可由任何计算机、控制器和/或软硬件组合，能够选择和控制xyz扫描参数和激光照射。 [0080] - In general, the control system 103 transmits the laser beam 104 can be any computer, controller or a combination of hardware and / xyz to select and control the scanning parameters and the laser irradiation. 运些组件通常可至少部分与电路板接口相连，电路板与xy扫描仪、Z聚焦装置和/或激光器相接。 These components are typically transported may be partially connected to at least an interface circuit board, the circuit board and the xy scanner, Z focusing means and / or a laser contact. 该控制系统也可W，但不一定必须，进一步控制其它的系统组成部件，W及维护数据、获取数据和执行计算。 The control system may also W, but not necessarily, further control other system components, W, and maintaining data, perform calculations, and data acquisition. 因此，控制系统应包含指导激光器从一个照射图案切换到更多照射图案的程序。 Thus, the control system should contain guidance from a laser irradiation pattern is switched to more irradiation pattern program. 同样，该控制系统也许能够处理来自生物缝隙扫描激光器的数据和/或来自缝隙扫描激光系统的单独控制器的数据。 Similarly, the control system may be able to handle data and / or a separate controller from the slit scanning laser system from a biological slit scanning laser. 缝隙扫描激光系统是一个用于测量眼睛内部光学表面位置的系统，如晶状体前部和后部、角膜表面或其它眼睛特征，如晶状体白内障。 Slit scanning laser system is a system for measuring the internal optical surface of the eye position, such as front and rear lenses, the corneal surface of the eye, or other features, such as a cataract lens. 控制系统采用运些测量来激发激光照射，执行预期的晶状体切口。 The control system uses these measurements transported to excite the laser irradiation lens perform the desired incisions.
[0081] 传送激光束104的激光光学系统102包括激光扩束镜105、Z焦点机械装置106、 光束组合器l〇7、xy扫描仪108和聚焦光学系统109。 [0081] The laser optical system for transmitting the laser beam 104 includes a laser 102 beam expander 105, Z focus mechanism 106, a beam combiner l〇7, XY scanner 108 and the focusing optical system 109. 另有继电器光学系统110、包括变焦的摄像机光学系统111和CCD摄像头112。 Another relay optical system 110, a camera including a zoom optical system 111 and a CCD camera 112.
[0082] 眼睛114的光学图像113,特别是眼睛114的天然晶状体光学图像115是沿着一条路径113传送。 Optical image 113 [0082] 114 to the eye, especially the natural lens 115 of the optical image of the eye 114 is transmitted along a path 113. 运条路径113与激光束104的路径相同，从天然晶状体115到激光患者界面116,再到聚焦光学系统119,再至xy扫描仪108,最后至光组合器107。 Transport paths 113 and 104 to the same path of the laser beam, the laser from the natural lens 115 to patient interface 116, and then to the focusing optical system 119, and then to the xy scanner 108, and finally to the optical combiner 107. 另有一个激光患者界面116和一个结构化光117和一个带镜头的结构化光源照相机118。 Another patient interface 116 and a laser structured light 117 and a structured light camera 118 with a lens. 应用于本系统的患者界面及相关仪器的实例出现于美国申请12/509, 021，《眼科激光手术用液体灌装指标匹配设备》（代理人申请案编号：12212/53)，《眼科激光手术用液体支撑界面设备》（代理人申请案编号：12212/47),申请日期为2009年7月24日，申请号12/840,818,《眼科激光手术用液体支撑界面设备》（代理人申请案编号：12212/70)，申请日期为2010年7月21 日，W上各件的全部披露内容在此均可作参考。 Patient interface and related equipment used in the system are examples appeared in the US application 12/509, 021, "ophthalmic laser surgery with index matching liquid filling equipment" (Attorney Docket No: 12212/53), "ophthalmic laser surgery liquid interface support equipment "(Attorney Docket No: 12212/47), the date of application is 24 July 2009, application No. 12 / 840,818," with liquid ophthalmic laser surgery support interface device "(Attorney Docket No. : 12212/70), the filing date is July 21, 2010, the entire disclosure of each piece on W here can reference.
[0083] 结构化光源117可为有聚焦和结构化光投影光学系统的缝隙照明系统，如Schafter+KirchhoffLaserMacroLineGenerator型号13LTM+90CM，（类型13LTM-250S -41+90CM-M60-780-5-Y03-C-6)或Stocke巧ale型号SNF-501k660-20-5,也被称为缝隙扫描激光器。 [0083] The structured light source 117 may be a slit illumination system and a focusing structured light projection optical system, such as Model Schafter + KirchhoffLaserMacroLineGenerator 13LTM + 90CM, (type 13LTM-250S -41 + 90CM-M60-780-5-Y03- C-6), or ale type Stocke clever SNF-501k660-20-5, also called a slit scan laser. 在本具体实施方式中，结构化照明源117还包括缝隙扫描工具119。 In the present embodiment, the structured illumination source 117 further includes a slit 119 scan tool.
[0084] 当使用扫描缝隙照明系统时，手术包括在晶状体一侧定位缝隙、保存图像，然后将缝隙移动大约一条缝隙的宽度，再保存一次图像，然后重复运一动作，直至观察完整个晶状体。 [0084] When a scanning slit illumination system comprising a surgical lens positioned on one side of the slot, save the image, and then move the slit gap width of about one, and then save the image once, and then repeatedly run through a motion, observed until a complete lens. 例如，一条100ym的缝隙宽度可W用90张图像扫描标称直径9毫米的瞳孔散大，使用30赫兹帖率的摄像机，大约耗时3秒。 For example, a slit width W may 100ym nominal diameter of 9 mm mydriasis, using a 30 Hz rate posts 90 with an image scanning camera, takes about three seconds. 为使前表面获得的图像为无重叠的单一图像，缝隙应该与结构化光源相机118的轴成一个角度，也就是说，不应与该轴平行。 In order to obtain an image of the front surface of the non-overlapping single image, the slit should be structured with the light axis of the camera 118 at an angle, that is, not parallel to that axis. 标称缝隙角度与结构化光源相机的轴所成的角度约为30-60度。 The nominal gap angle of the structured light camera axis an angle of about 30-60 degrees. 在摄像机敏感性范围内的任何可见或近红外波长光源都可使用。 Any visible or near infrared wavelength range of the light source in the camera's sensitivity may be used. 在结构化摄像机图像中，低相干长度光源更利于减少散斑噪声。 In the structure of the camera image, the low coherence length light source is more conducive to reduce speckle noise.
[0085] 结构化光源照明源117和结构化光源摄像机118成直角关系。 [0085] Structured light illumination source 117 and a structured light camera 118 into a right angle relationship. 该直角的关系可能包括调整结构化光源摄像机探测器与摄像机光学系统轴所成的角度，运在众所周知的Scheimpflug配置中可能出现但并非是必须要求的。 Relations may comprise the adjustment of the angle of the structured light camera detector and the camera optical system axis by an angle, operation is possible but not necessarily required in the known Scheimpflug configuration. 结构化光源117连同缝隙扫描装置119,W-个角度或多个角度投射一条线或一组线到角膜和晶状体115上。 Structured light source 117 together with the slot scanning device 119, W- plurality of angles or projecting angles a line or set of lines onto the cornea and lens 115. 从运些对象上散射出的光束被晶状体115聚集于摄像系统118。 Scattered from the beam transport these objects are gathered in the imaging lens system 118 115. 由于角膜和晶状体115的缝隙照亮图像与摄像机间的夹角角度较大，运表示摄像机的大景深和整个缝隙图像可能并非急剧聚焦在摄像机内。 Because the included angle between the cornea and the lens of the camera image illuminated by the slit 115 is large, showing large depth of field of the camera operation and the entire slit image may not sharply focused in the camera. 通过将摄像机倾斜一个角度或多个角度，沿着照亮图像平面的图像可W更加急剧地聚焦。 By the camera inclined at an angle or multiple angles to illuminate the image along the image plane W may focus more steeply. 在某种程度上，如果未能获得更加急剧的聚焦，将使用算术数据评价手段进一步确定更精确的关于激光设备照明结构的位置。 To some extent, if the failure to obtain a sharper focus, the arithmetic data evaluation means further determines a more accurate location of the illumination structure of the laser device.
[0086] 或者，结构化光源照明源可为一条聚焦光束，其焦点扫描眼内所有感兴趣的区域。 [0086] Alternatively, the structured light illumination source can be focused as a beam, all the region of interest within its focus scans the eye. 该光束的扫描路径可能模拟上述扫描缝隙照明系统照亮的区域，通过对眼睛平面进行光栅扫描，类似于眼睛被缝隙激光器照亮。 Scanning path of the beam is possible to simulate the scanning slit illumination region illuminated by raster scanning plane of the eye, the eye is similar to the laser illuminated slit. 由此而论，光栅扫描指的是一个过程，在该过程中，光束焦点被逐行扫描，照亮眼睛的一个区域。 In this context, it refers to a raster scanning process, in the process, the progressive scan beam focus, to illuminate a region of the eye. 在运种情况下，摄像机的探测器会在整个光栅扫描的过程中暴露在散射光束的散射光线中。 In the transport case, the camera can be exposed to the probe beam scattered light scattered in the raster scan of the entire process.
[0087] 从摄像机118获得的图像可被传送至控制器103进行处理，并用于系统运行。 [0087] The images obtained from the camera 118 may be transmitted to the controller 103 for processing, and for system operation. 它们也可被送到一与控制器103相连的、独立的处理器和/或控制器。 They may also be sent to the controller 103 is connected to a separate processor and / or controller. 结构化光源117、摄像机118W及缝隙扫描装置119,包括一用于确定晶状体和角膜表面相对于激光系统的位置的装置，也即包括一相对于激光系统而确定晶状体和其顶端的位置的装置。 A structured light source 117, camera 119 118W and the slot scanning device, comprising a means for determining the position of the lens and the corneal surface of the apparatus with respect to the laser system, i.e. comprising determining a relative position of the lens and the tip end thereof to the laser system.
[008引此处提供了摘除晶状体的激光照射图案的传送方式。 [008 cited herein provide the transmission of a laser irradiation pattern of removal of the lens. 因此，此处提供了开创切口的方法与系统，即在晶状体前囊开创切口。 Thus, it provided herein a method and system to create a cut, i.e., the anterior lens capsule incision created. 运些切口由医用激光束104开创，光束W精确的预先确定的高度可重复模式向晶状体前囊传送，导致精确的预先确定的高度可重复的成形的切口，或可能被要求用于特定人工晶状体或其它设备或材料植入晶状体囊内。 These incisions created by the operation medical laser beam 104, the beam pattern W highly repeatable precise predetermined anterior lens capsule to the transmission, resulting in highly precise repeatable predetermined shaped incision, or may be required for a particular IOL or other materials or devices implanted lens capsule. 此处几何形状的模式或切口指的是圆形和楠圆形模式或切口。 Here geometry or pattern and a circular cutout refers Nan circular pattern or incision. 此处非几何形状的模式或切口是指除圆形和楠圆形之外的所有其它形状。 Non-mode geometry or cuts herein refers to all shapes other than circular and Nan circular.
[0089] 在晶状体前囊开创运些切口的方法和系统提供了优于先前公知的手持设备和装置的结果，应用于撕囊和囊切，因此，此处披露的运些方法和系统被认为是运些技术的实质性进步。 [0089] In the anterior lens capsule to create a method and system for transport of these cuts provides better results previously known devices and handheld devices, and applied capsulorhexis capsulotomy, therefore, a method disclosed herein and the operation of these systems are considered these techniques are shipped substantive progress. 此外，激光照射图案的传送是W大大降低漏切风险的方式进行，取决于特定的应用程序，传送可能具有十分重大的意义。 In addition, the transmission of the laser irradiation pattern is W greatly reduce the risk of missed cut was way, depending on the particular application, the transfer may have great significance. 而且，前囊可事先预想假设可能是一个连续切口，切口和平面（切口之间未切的囊部分）和穿孔。 Further, before the capsule can be envisioned prior assumption may be a continuous cutout, and the cutout plane (uncut part between the cut-balloon) and perforations. 因此，此处使用的术语"漏切"或"漏切们" 指的是原本是要执行一个特定的激光照射图案的传送来开创一个切口，但却因为激光束错过了晶状体囊或目标晶状体材料而未能形成切口，或者击中了目标材料但却未成功形成切口。 Thus, as used herein the term "miscut" or "miscut are" originally refers to perform a particular transmission pattern of laser irradiation to create an incision, but since the laser beam to miss the target lens material or lens capsule It failed to form an incision, or hit the target material, but success is not a cut. 因此，在切口和平面模式下，如果原来想要被激光模式保留未切的平面将不会被认为是漏切。 Thus, at the incision and the planar mode, if the original plane desired to be retained uncut laser mode it will not be considered missed cuts.
[0090] 晶状体前表面的切口是用于在晶状体囊内开一个孔，W便摘除晶状体的内部结构。 [0090] The front surface of the lens is the notch for opening a hole in the lens capsule, W will be removal of the internal structure of the lens. 为辅助摘除，此处提供了多种激光照射图案将晶状体内部结构剖切为较小的体积块，小到可W从晶状体囊中摘除。 Auxiliary removal, laser irradiation provided herein various internal structure of the lens pattern cut into smaller volume blocks, small W can be removed from the lens capsule. 运些小体积块的范围从约0.Imm3到约30mm3不等，优选范围从约0.4mm3到约Imm3不等。 Some small transport blocks range from about 0.Imm3 volume ranging from about 30mm3 to, preferably in the range from about Imm3 to vary from about 0.4mm3. 因此，可W在晶状体内部结构中应用网格激光照射图案，创造出内部晶状体材料的立方体形状体积块。 Thus, W may be applied in a grid pattern of laser irradiation of the internal structure of the lens, creating a cube-shaped volume of mass inside the lens material. 运些立方体的单侧长度范围可能在约100微米至约3毫米、4毫米之间，优选范围是约500微米至2毫米之间。 These one-sided cube transport length may range between about 100 microns to about 3 mm, 4 mm, preferably in the range of between about 500 microns to 2 millimeters. 体积形状最理想的大小是与抽吸管末端开口的尺寸相匹配。 Ideally the volume of the shape size matches the size of the opening end of the suction tube. 运样单个的体积形状块就能很容易地被吸入抽吸管，不使用或者最低程度地使用超声能量。 Sample transport volume of the individual shape of the block can be easily sucked into the suction tube, or the use of ultrasonic energy without using minimally. 比抽吸管开口小很多的体积形状块需要更多的激光照射， 却没有显著增加的益处。 Much smaller than the volume of the suction tube opening shapes blocks need more laser irradiation, but no significant increase in benefit. 另外，本发明不限于应用于形成相似的一般大小的立方体和其它形状的体积块。 Further, the present invention is applied is not limited to a similar volume of formation and other shaped blocks generally cube size. 例如，除了图6A-6C中显示的球体外，其它形状如S角形和圆切片形状的体积形状也可应用。 For example, in addition to outside the sphere shown in FIGS. 6A-6C, other shapes such as a circular shape and volume of the angular S-shaped sections may be used.
[0091] 晶状体前囊的激光切口是用于在晶状体囊的前表面开一个小的开口，W便摘除内部结构中的分段体积块。 [0091] The anterior lens capsule is laser cut for opening a small opening in the front surface of the lens capsule, W will be removal of the internal structure of the block segmentation volume. 因此，该手术可W用于治疗白内障。 Thus, W can be used for the treatment of cataract surgery. 该手术也可W用来摘除已浑浊但尚未发展成白内障的晶状体。 This procedure can also be used for the removal of W has not yet developed into a cloudy cataract lens. 该手术可能会进一步用于摘除透明但已失去调节能力的天然晶状体。 The surgery may be further used to remove the transparent but has lost the ability to regulate the natural lens. 在W上所述的情况下，摘除晶状体后，晶状体囊内将会被放入合适的替换材料， 如人工晶状体、调节型人工晶状体、或合成晶状体填充材料。 In the case of the W, after removal of the lens, the lens capsule will be placed in a suitable substitute material, such as intraocular lens, IOL adjustment, the lens or synthetic filler. 此外，开口的尺寸和形状是可变并可精确控制的，最好是目前已知的晶状体填充材料和人工晶状体，对直径为2毫米或更小的晶状体填充应用5毫米的人工晶状体。 Further, the size and shape of the openings is variable and can be precisely controlled, the best known is the intraocular lens and the lens filling material, a diameter of 2 mm or smaller lens filling applications IOL 5 millimeters.
[0092] 图IOA-D显示外科医生摘除晶状体的囊切。 [0092] FIG IOA-D display surgeon removed capsulotomy lens. 运些图片有一个外表面801，其表面是由晶状体囊形成，因此其形状是晶状体的外形。 Yun some pictures having an outer surface 801, which surface is formed by a lens capsule, and therefore the outer shape of the lens. 另外还有一个环形带状切口802和照射模式。 There is also an annular band-shaped notch 802 and the irradiation pattern. 该照射模式是把激光束排成一系列紧密排列的照射，置于环形周围最深处中（大多数位于后部的环形），然后继续重复操作，环形深度随之减少。 The irradiation pattern is irradiated with a laser beam are arranged in a series of closely spaced, annular placed around the deepest (most at the rear of the ring), and then repeat the operation continues, the depth of the annular reduced. 因此，一般来说，在转移到更浅的深度之前，照射将会被分布在整个环形周围的一定深度。 Therefore, in general, prior to transfer to a shallower depth, the irradiation will be distributed at a depth around the entire ring. 因此，本图显示此圆柱形切口的横截面及相对应的环形的两侧802。 Thus, this figure shows on both sides of this cylindrical cut 802 and the corresponding cross-section of the annular. 此处的环形囊切切口在尖端约有100微米深，由上述参考方法确定，在晶状体前囊表面，直径大约为5毫米。 Here annular balloon-cut slit in the tip is about 100 microns deep, is determined by the reference method, the surface of the anterior lens capsule, a diameter of about 5 millimeters. 囊切的直径为约0. 1毫米至约9毫米之间。 Capsulotomy diameter between about 0.1 mm to about 9 mm.
[0093] 既然晶状体囊大约有5到15微米厚，因此期望切口的深度典型在5至数百之间， 虽然多切几毫米，并不会受到惩罚。 [0093] Since the lens capsule about 5 to 15 microns thick, and therefore the desired depth of the notch is typically between 5 to hundreds, although many cut a few millimeters, and will not be penalized. 有了更精确的位置和晶状体形状及晶状体顶端的形状， 晶状体囊上和房水中的带厚，特别是带的数量就能下降。 With a more accurate position and shape of the lens shape and lens top, with a thickness of the lens capsule and the aqueous humor, in particular the number of bands can be decreased. 囊切的形状可W是楠圆形，不同的X轴，然后是y轴或其他形状。 Capsulotomy Nan circular shape may be W is, different from the X-axis and y-axis, or other shapes. 因此，囊切的形状可W是任何有利于特定人工晶状体的形状， 例如囊切的形状可W是圆形、楠圆形、正方形、长方形或非几何形状。 Thus, the shape of the capsulotomy may be of any shape conducive W specific IOL, e.g. capsulotomy W shape may be circular, Nan circular, square, rectangular or non-geometric shapes. 该形状将至少部分基于并至少部分由人工晶状体的某些方面而确定，特别是调节型人工晶状体或那些减少或消除戴镜需求的人工晶状体。 The shape and at least partially based on at least in part determined by certain aspects of the intraocular lens, especially those regulated intraocular lens or IOL reduce or eliminate the need spectacles. 一个特定的人工晶状体，如此处讨论的FDA批准人工晶状体，可能得益于并/或可能需要一个特定的囊切的形状和光滑的开口。 A particular IOL, as discussed herein the FDA approved IOL, may benefit and / or may require a particular shape of the capsulotomy and smooth the opening.
[0094] 图9显示了一个精确的预先确定的非几何结构切口，该切口的开创通过实施预先确定的与图8所示的人工晶状体相关的照射模式而完成。 [0094] Figure 9 shows a non-precise predetermined notch geometry, to create the incision IOL associated illumination mode shown in FIG. 8 by a predetermined embodiment is completed. 因此，此处提供了一个人工晶状体结构502、邮邻晶状体结构502的较链503、与晶状体囊501相接触的触觉系统504。 Thus, provided herein a structure of the intraocular lens 502, the lens structure is chain-mail o 503 502, the system 501 with the lens capsule haptic contact 504. 另外还提供了一个精确的预先确定的非几何结构囊切505,带有两个非线性，即：曲线区段， 和两个本质线性，即：直线区段。 It also provides a precise geometry of the predetermined non capsulotomy 505, with two nonlinear, namely: curve section, and two essentially linear, that is: a straight line segment. 图9还进一步说明了运些段的位置，本质直线区段位于较链内部，即，如此一来，余留的晶状体囊至少部分覆盖触觉系统，曲线区段位于晶状体结构502内部，即余留的晶状体囊覆盖晶状体结构502的外侧。 Figure 9 further illustrates the position of some transport segment, more essentially straight section located inside the chain, i.e., Thus, the remaining lens capsule at least partially covers haptic system, located inside the curved section of the lens structure 502, i.e., the remaining covering the outside of the lens capsule of the lens structure 502. 运种类型的囊切被称为全开(A化-ON)。 Types of transport is called full capsulotomy (A of -ON). 运一切口和模式将是主要遵循人工晶状体形状的切口、开口、囊切和模式的例子。 Operation mode and a cut will be mainly follows the shape of the incision intraocular lens opening, and examples capsulotomy mode.
[0095] 运些活动进行的顺序可取决于内部晶状体结构的特定性质，如白内障的密度、白内障的位置、用来摘除内部晶状体材料的装置、一旦晶状体材料被剖切为较小的体积块后所使用的激光类型和能量、激光所产生的气泡数量和尺寸和其他因素。 [0095] The operation sequence for these activities may depend on the particular nature of the internal structure of the lens, such as density cataract, cataract position, means for removal of the internal lens material, lens material is once cut into smaller volume blocks the number and size of bubbles and other factors used and the type of laser energy, the laser produced. 因此，虽然此处的实例提供了实施晶状体前表面切除和晶状体内部结构切片活动的顺序，但应当认识到的是， 运一顺序是可W改变的，本质上来讲它们是可W同时实施的。 Thus, although the examples herein provide sequential removal of the front surface and internal structure of the lens sections active lens embodiment, it should be appreciated that the order of operation is a change of W, which is the essence of W simultaneously.
[0096] 优选的用于治疗患者的激光系统能够对晶状体囊进行精确的和预先确定的切口开创，从而得到精确和预先确定形状的囊切。 [0096] Preferred for treating a patient's lens capsule laser system capable of precise and pre-determined to create the incision, thereby obtaining precise and predetermined shape capsulotomy. 因此，此处提供了获取和分析人工晶状体形状和结构的方法，特别是获取和分析调节型人工晶状体、能够减少并/或消除戴镜需求的人工晶状体和/或用于近距离、中等距离和远距离视力的人工晶状体、包括但不限于上述抑A 批准版本的人工晶状体的形状和结构。 Thus, methods provided herein and obtain IOL shape and structure, in particular, to acquire and analyze accommodating intraocular lens can be reduced and / or eliminated IOL needs spectacles and / or for the near, intermediate and distance distant vision IOL, including, but not limited to the approved version of the artificial lens suppressors a shape and structure. 基于运一分析，能够确定应用于特定人工晶状体的囊切的优化形状和位置，或类似形状的人工晶状体的分类。 Based on an analysis operation can be determined to optimize the shape and position of the applied specific capsulotomy intraocular lens or IOL classification of similar shape. 然后向激光系统提供执行运一优化形状囊切的预先确定的照射模式，最好是向控制系统103提供运一照射模式。 Is then provided to the laser system operation performed a predetermined shape of the irradiation pattern of a capsulotomy optimization, it is desirable to provide a transport mode to the illumination control system 103. 该激光系统然后可W用于一个或W下所有程序，确定晶状体前表面特别是晶状体囊前表面的形状和位置、确定与激光系统相关的晶状体囊的顶点、执行为特定类型人工晶状体选定了精确和预先确定的形状的激光囊切，W及天然晶状体材料的摘除。 The laser system may then be used for all procedures a W or W, in particular to determine the surface shape and position of the lens capsule front surface of the front lens, the vertex associated with the determined lens capsule laser system, perform selected for a particular type of IOL precise and predetermined shape laser capsulotomy, W, and removal of the natural lens material.
[0097] 因此，此处提供了向人眼晶状体传送激光束的技术、系统和设备，在特定情形下， W-种精确且预先确定的方式向眼内的晶状体囊传送，W实施预先确定的囊切。 [0097] Accordingly, techniques are provided herein, systems and apparatus to transmit a laser beam lens of the eye, under certain circumstances, precise and W- seed capsule in a predetermined manner is transmitted to the lens in the eye, W embodiment the predetermined capsulotomy. 运些模式的形状可W通过银曲或环形传送序列进行传送。 These modes may be shipped shape W is transferred by the transfer sequence Yinqu or annular.
[0098] 当应用激光辅助白内障手术时，在使用光致破裂激光切除核的过程中，会导致柔软皮层附近形成足够多的气泡，使得气泡漫向晶状体囊。 [0098] When laser assisted cataract surgery, during use of the laser ablation photodisruption core, the flexible skin layer will cause near enough bubbles, the bubbles diffuse such that the lens capsule. 在运些情况下，气泡汇集在靠近前囊的位置，当激光试图切囊时，突然间释放的气泡可能会在传送激光照射图案过程中改变前囊的位置，导致激光未击中囊，导致至少在囊周围的圆周部分不能成功开创切口。 In some cases transport, air bubbles collected in the capsule near the front position, when the laser capsulotomy attempt, between the release of the bubbles may suddenly change in position of the anterior capsule during the transmission of the laser irradiation pattern, resulting in a miss laser balloon, resulting in at least not successfully created cuts around the circumference of the balloon portion. 要解决运个问题，此处提供了一个特殊的剖切模式，该模式对囊位置与时间的依赖性较小，不管在激光囊切手术过程中位置是否变化，均能完成囊切除。 To solve the transport problem, here it offers a special cut-away mode, the mode sac location and time-dependent small, regardless of whether the change in position in the laser capsulotomy during surgery, can complete resection of bladder. 因此，能够大幅度减少或完全消除漏切现象。 So, can significantly reduce or completely eliminate the phenomenon of missing the cut.
[0099] 此处还提供了W高速率大范围Z扫频的激光照射图案的应用，而XY位置W圆形或楠圆形或其他模式或理想的形状W较慢的速度移动，W便激光剖切动作能够在本质上同一个XY位置多次发生。 [0099] Here also provides the use of a wide range of high-rate W Z swept laser irradiation pattern, the XY position W Nan circular or circular or other desired shape or pattern W moves slower speed, then the laser W cut action can occur multiple times in the same XY position on nature. 因此，可W想象，激光束的操作就像是线银刀片快速上下拉动，对比XY定位来开创切口形状。 Thus, W may be imagined, the operation of the laser beam like a line is pulled down fast silver insert, to create contrast XY positioning cut shape. 在运种情况下，如果运个前囊在剖切过程中由于气泡传播或其他原因而产生移位，仍然会继续对囊进行剖切，虽然可能会在Z方向中屯、区域之外的照射上下分布，而且更多可能移至该分布的前部或后部末端。 In the transport case, if the operation before the bubbles propagate a balloon or other reasons taken in the course of being displaced, the balloon will continue to be cut, although it may be irradiated outside village, the region in the Z-direction vertical distribution, and more likely to move the front or rear end of the distribution. 针对核的激光剖切，会有大量的气泡产生，就面积而言，Z范围或上下范围内，剖切应该为大约1毫米，集中于前囊，允许大约+/-475微米的囊偏移，并仍能切开25微米厚的囊。 For nuclear laser cut, there will be a large number of bubbles, in terms of area, or within the range Z the vertical range, should be about 1 mm cut, focused on the anterior capsule, allowing the balloon to about 475 microns +/- offset and still cut 25 microns thick capsule.
[0100] 除了使手术中运动的囊能够被剖切，运一手术可W用来弥补由比如测量误差而带来的囊位置静态误差。 [0100] In addition to the balloon moving operation can be cut, W may be transported to a surgery such as to compensate for the measurement error caused by the position of the balloon static error. 运样，Z范围的程度可W由已知的系统误差增加。 Sample transport, W degree Z can be increased by a range of known systematic error.
[0101] 除了此处披露的较大Z范围扫频，此处还考虑使用一个较小Z范围内的剖切运动， W应对囊位置不确定的情形，此处的位置不确定可能来自于静态测量误差和因位置改变可能比预期更小。 [0101] In addition to herein disclosed a large Z range sweep, here also consider using a smaller cut motion in the range of Z, W response to the uncertain situation sac position, a position where uncertainty may come from static and a measurement error due to change in position may be less than expected. 可能范围在数百微米，或高度精确的测量数据的情况下和手术中囊的近零运动，在运种情况下，Z范围可能为数十微米范围一-足W剖切囊的厚度。 In the case of the possible range of hundreds of microns, or highly accurate measurements of near zero motion and bladder surgery, in the transport case, Z may be a range of tens of micrometers - W cut foot bladder thickness.
[0102] 囊切中的Z范围扫描，照射模式提供了在白内障摘除手术中优化激光手术去除效率的能力。 [0102] Z range of the scanning of the balloon hit, provides the ability to optimize the irradiation pattern of laser surgery in cataract surgery removal efficiency. 因此，晶状体核可在进行囊切之前分段成小体积块。 Thus, the lens capsule during approved segmented into small blocks before cutting. 在运种情况下，由核切片形成的任何气泡将会被困在囊内。 In the transport case, any gas bubbles formed by the core sections will be trapped within the capsule. 通过维持气泡位于囊中，对比于它们逃离出囊并迁移到房水或汇集并形成于角膜后部附近而产生的影响而言，它们对激光传输的影响就会被降低。 By maintaining the air bubble is in the bag, in contrast to their escape from the bladder and migrate into the aqueous humor or in terms of the impact were pooled and formed near the rear portion of the cornea is generated, which will affect the laser transmission is reduced. 向气泡照射激光束的不利影响随着光束穿过气泡后至到达其预期位置需要通过的距离的增加而增加。 As the distance increases to reach its intended position required by the beam passes therethrough to the adverse effects of bubbles increases the bubble irradiating a laser beam. ，因此，通过捕获气泡于囊中，运一距离被限制为绝对最小，因此其射穿气泡的不良影响，也同样最小。 Therefore, by trapping air bubbles in the bag, a transport distance is limited to an absolute minimum, and therefore its adverse effects of air bubbles penetrate, it is also minimized.
[0103] 然而在囊中累积的气泡增加了晶状体和/或囊在囊切中转移的可能性，因为气泡可能通过晶状体囊上的切口跑出。 [0103] However, the bubbles accumulated in the increase of the lens capsule and / or the possibility of the transfer of the balloon hit the balloon, because bubbles may run out through an incision in the lens capsule. 如前所述，运一位置转移可能导致漏切和不完整的囊切。 As described above, the transfer operation may result in a miscut position and incomplete capsulotomy. 因此，Z范围横扫避免了晶状体或囊移动产生的任何漏切，并相应提供了增加激光效率、减少气泡不利影响和减少囊切中漏切的促进优势。 Thus, Z sweep range to avoid any leakage or the lens capsule by movement of the cut, and accordingly provides increased efficiency of the laser, reducing the adverse effects of bubbles and reduces the advantage of facilitating the balloon hit drain cut.
[0104] 因此，此处提供了一种优化激光手术效率的系统和方法。 [0104] Thus, it provided herein a system and method for optimizing the efficiency of laser surgery. 在本发明一具体实施方式中，通过允许核首先被切除，由此切除而形成的气泡则被包含在囊中，直到囊切完成。 In a specific embodiment of the present invention, first, by allowing the core is cut, thereby cutting the formation of bubbles were contained in the bladder until the bladder is completed cut. 将气泡包含于囊中避免了必须通在前房射穿气泡，但需首先创建囊切。 The air bubbles contained in the capsule in the anterior chamber avoids having to penetrate through the bubble, but the need to first create capsulotomy. 然而，运一解决方案会导致气泡在晶状体纤维内大量累积，可能导致囊在囊切的过程中移动。 However, a solution to transport bubbles cause an accumulation of the fibers in the lens may cause the balloon from moving during the capsulotomy. 为了解决运一潜在移动，本发明还提供了不同Z方向运动的激光束。 To address a potential movement operation, the present invention also provides a laser beam in different Z-direction movement. 然而，应该理解有一种囊移动不确定性较小的情况，即是在囊切中，激光剖切先于核材料剖切，气泡不放入晶状体内。 However, it should be understood that there is a small movement of the balloon Uncertainty, i.e. the balloon is hit, taken prior to laser cut nuclear material, no bubbles into the lens. 在运种情况下， 如果位置的不确定性足够小，那么Z范围的程度足够小，因此只有较小数量的气泡可能出现在前房，不会干扰核的激光剖切。 In the transport case, if the position uncertainty is sufficiently small, then the degree of Z range is small enough so that only a small number of bubbles may appear in the first room, the laser does not interfere with the core cut. 此处应该进一步理解为，当指的是结构剖切的顺序时， 如本段所述，当执行一个顺序满足一个结构的大部分先于另一个结构被剖切，例如，在向第一个结构传送照射模式时放置一些激光照射并不能防止第一个结构被认为是顺序当中的第一个结构。 Here will be further understood that, when referring to the sequence structure when cut, as described in this paragraph, performing a sequence satisfy a majority of structure is first cut to the other structure, e.g., as in the first place some laser irradiation irradiation pattern when transmitting a first configuration not prevent the structure is considered to be among the first structural order.
[0105] 还有更多的方法和系统定义眼睛结构尤其是前囊的高精度位置测量，通常能提供更高准确性、高精度和患者至患者眼睛可重复性手术，特别是囊切，在申请号12/509, 412 (《一种从眼睛晶状体中摘除和置换晶状体材料的方法和系统》），申请日期为2009年7月24日，代理人申请案编号：12212/51,其全部披露内容在此均可作为参考。 [0105] The methods and systems also more defined structures of the eye, especially the high-precision position measurement of the anterior capsule, generally provide greater accuracy, precision and repeatability of the patient to the patient's eye surgery, especially capsulotomy, in application No. 12/509, 412 ( "an removal and replacement of the lens material from the lens of the eye in a method and system"), filing date of July 24, 2009, Attorney Docket No: 12212/51, the entire disclosure the content can be used as reference.
[0106] 此处提供了一个进一步优化的方法和系统，用于提高从晶状体囊中抽吸晶状体材料的灵活性。 [0106] where further optimization provides a method and system for improving the flexibility of the lens material from the suction of the lens capsule. 在切片晶状体材料的过程中，有可能纤维团的剖切碎片从囊袋中跑出，无论是由漂浮或因气泡或只是天然存在的，除非有手段进行阻止，总会有运样的碎片跑出。 In the process of sectioned lens material, there is a fiber cut debris may escape from the group of the capsular bag, either floating or simply due to air bubbles or naturally occurring, unless means to stop, there is always run by the sample transport debris out. 因此， 本方法和系统的另一个方面是提供一种手段来抑制运些碎片，直到他们预备好被抽吸出来。 Therefore, another aspect of the method and system is to provide a means to inhibit the operation of these fragments until they are ready to be drawn out. 运一手段的完成通过仅执行部分囊切除，余留的囊作为约束，预防和/或减少切片晶状体材料的跑出。 A transport means is completed only by performing the balloon portion cut, as the remaining bladder constraints, preventing and / or reducing sectioned lens material ran. 一旦囊的部分切除要求可W完成抽吸，即囊切是完整的，切片晶状体材料被抽吸出晶状体囊。 Once the balloon portion W may be cut in claim suction completion, i.e., complete capsulotomy, lens material is aspirated slice the lens capsule.
[0107] 此处提供的激光照射图案中，优选普遍遵循晶状体形状的激光照射图案，模式中单个照射的放置与相邻照射互相之间足够接近，如此一来，当模式完成后，晶状体材料的一个足够连续的层和/或线和/或体积则被摘除。 [0107] Laser irradiation pattern provided herein, preferably generally follow the shape of the lens pattern of laser irradiation, the irradiation pattern is placed between the adjacent single irradiation with sufficiently close to each other, this way, when the mode is completed, the lens material a sufficiently continuous layer and / or lines and / or volume were removed. 在此作为必要，仔细考虑了较短的照射间隔或更长的距离，包括重叠，来获得期望的结果。 Here, as necessary, careful consideration of the irradiation interval shorter distance or longer, including overlapping, to obtain the desired results. 照射间隔考量包括气泡耗散、体积摘除效率、排序效率、扫描仪性能和分裂效率等等。 Considerations include the irradiation interval bubble dissipation, volume removal efficiency, efficiency of sorting, splitting efficiency and performance of the scanner and the like. 例如，作为说明，针对5障碍物大小光点，能量大小足W引起光致破裂，20微米或更大的间距导致单个的气泡，不聚合且散失速度更快，相比之下，相同能量下较近的照射间隔将导致气泡聚合。 For example, as described, for spot size of the obstacle 5, the amount of energy sufficient to cause photodisruption W, a pitch of 20 microns or more resulting in a single bubble, and do not polymerize faster loss, compared at the same energy closer spacing will cause bubbles irradiation polymerization. 随着照射间隔变近，体积效率增加。 As the irradiation interval becomes short, the volume efficiency is increased. 随着照射间隔变近，气泡聚合也随之增加。 As the irradiation interval becomes nearly bubble polymerization also increases. 然后出现一个转折点，照射间隔近到一定程度， 体积效率就大幅下降。 Then occurs a turning point, the irradiation interval near to a certain extent, the volume efficiency dropped significantly. 例如，作为说明，在分裂透明眼睛组织时，一个450飞秒的脉冲宽度和2微焦耳的能量W及约5微米的照射大小和10微米的分离结果。 For example, as described, when the split transparent tissues of the eye, the size of the irradiation a pulse width of 450 fs and 2 microjoules of energy W and about 5 microns and 10 microns separation results. 此处使用的术语分裂指的是大幅度分离组织。 The term refers to a substantial split separate organization. 此外，对照射间隔的更小或更大程度的考量，基于完成此处对象的当前披露内容，本领域内的普通技术人员将知道如何评价运些条件。 In addition, a smaller or greater degree of consideration irradiation interval, based on the completion of the object's current disclosure herein, one of ordinary skill in the art will know how to evaluate some transport conditions. 最后，仔细考虑了单个照射模式的放置相关于相邻照射模式可能通常情况下尽可能较近，通常通过光致破裂物理现象的大小和时间帖进行限制，可能还包括其它，比如先前照射的气泡膨胀。 Finally, careful consideration of the placement of a single irradiation pattern correlation may normally close as possible to the adjacent illumination mode, typically limited by physical phenomena photodisruption size and time post, it may also include other, such as the previously irradiated bubbles expansion. 此处使用的光致破裂物理现象时间帖指的是光致破裂周围发生的影响，比如等离子体形成与膨胀、冲击波传播、气泡膨胀和收缩。 Photodisruption time physical phenomena used herein, refers to a photo-post effects occurring around the fracture, such as plasma formation and expansion of the shock wave propagation, expansion and contraction of the bubble. 因此，序列脉冲的时机，它们的时间快于部分或所有运些效果，可W增加体积摘除和/或分裂效率。 Thus, the timing sequence of pulses, the time they run faster than some or all of these effects, W may be removed to increase the volume and / or splitting efficiency. 相应地，我们建议使用从50兆赫到5兆赫的脉冲重复频率，可通过具备W下参数的激光器来完成：一个模式锁激光器，腔长3米至3厘米。 Accordingly, we recommend using a pulse repetition frequency from 50 MHz to 5 MHz, can be accomplished by a laser comprising the W parameters: a mode locked laser, the cavity length of 3-3 meters. 运样的高PRF激光器能够更容易地产生多脉冲重叠在一个位置，允许每脉冲W较低能量来达到光致破裂。 Sample transport high PRF lasers can more easily produce a multi-pulse overlap position, allowing a lower energy per pulse W to achieve photodisruption.
[010引术语第一、第二、第=，此处是相对术语，必须视上下文内容进行理解。 [010 cited terms first, second, =, where is a relative term, depending on the context content must be understood. 除非有特别说明，它们不与时间相关。 Unless otherwise specified, they are not related to time. 因此，第一切口后面必有第二切口。 Thus, there must be behind the first cut the second cut. 一般来说，优选点燃激光照射，一般在激光模式中是从后面的点到前面的点，W避免和/或使得从先前激光照射产生的气泡带来的影响最小。 In general, it is preferred to ignite the laser irradiation, the laser mode typically is a point from the back to the front of the point, W to avoid and / or minimize the impact of the bubble from a previously generated by laser irradiation. 但是，由于此处提供了不同的激光照射图案，从后至前的照射顺序并非严格限制的必要条件。 However, since here provide different patterns of laser irradiation, the irradiation order from the front to the rear of the necessary conditions are not strictly limited. 此外，在白内障的案例中，从前向后照射可能更有利，因为激光基本上不能穿透白内障。 Further, in the case of cataracts, it may be more advantageous illumination from front to back, since the laser can not penetrate substantially cataract.
[0109] 图11显示了从虹膜1105的瞳孔边缘1107所看到的晶状体1108。 [0109] FIG. 11 shows the edge of the lens iris from the pupil 1108 1105 1107 seen. 图中有两个照射和/或剖切区域。 While two irradiation and / or cut area. 中部区域1101有高剖切密度模式，如小球体，如1102,直径为0. 25到0.75毫米。 Middle region 1101 has a high density pattern cut, such as small spheres, such as 1102, having a diameter of from 0.25 to 0.75 millimeters. 图中还有外部区域1103,径向切口1104(曰)-1104化）。 There are further outer region 1103, radial cuts 1104 (reads) of -1104). 运些切口作为位于虹膜1105附近的晶状体材料的预切口。 These shipped as precut slit located near the iris of the lens material 1105. 在运种情况下，预切放射线可能通过外部应用力而倾向于向外传播至中缔线。 In the transport case, the radiation may be pre-cut tends to spread outwardly by an external force is applied associative line. 运一外力可能是一个机械手或手持仪器，也可W通过插入BBS或其他安全液体造成预切口向外传至中缔线。 A transport force may be a handheld device or a robot, W can also result in precut line spread outwardly by the insertion of associative or other security BBS liquids.
[0110] 图12显不了从虹胺1205的瞳孔边缘1207所看到的晶状体1208。 [0110] FIG. 12 not significantly from the pupil 1205 Rainbow amine edge 1207 of the lens 1208 seen. 图中显不了一种与图11相似的模式，除了放射形切口1204(曰)-1204化）延伸穿过晶状体中屯、并且首先被激光切除，W确保切除属性不受任何高密度剖切的干扰，例如球体，例如1202。 FIG not substantially similar to one kind of pattern in FIG. 11, except that the radial cuts 1204 (reads) of the -1204) extends through the lens in the village, and the first laser ablation, W ensure removal of any high-density property is not taken interference, such as spheres, for example, 1202. 确保放射形切口已完成，然后在放射形切口之间开创较小的切口，如球体，是目前优选并被认为是有利的。 To ensure that the radial cuts have been completed, and then create smaller incisions between the radial cuts, such as spheres, it is presently preferred and are considered to be advantageous. 模式11或模式12的纯粹效果是，拥有一个控制区域，能更容易地完成抽吸，因为外围区域放射形切口可能有机会被外力的施加延伸到中缔线。 Mode 11 Mode 12 is purely effect, it has a control area, the suction can be more easily accomplished, since the peripheral region of radial cuts may have the opportunity to be extended to the external force applied to the associated line.
[0111] 图13A和图13B分别显示了在同一激光照射图案下的晶状体的侧截面图和顶截面图。 [0111] FIGS. 13A and 13B show a side sectional view and a top sectional view of the lens of the laser irradiation in the same pattern. 图13C提供了晶状体和照射模式的预期视图。 Figure 13C provides a view of the illumination lens and the expected pattern. 因此，显示了晶状体囊1301。 Therefore, the display of the lens capsule 1301. 显示了一系列楠圆形放射形切口1302 (a)至1302 (f)，一系列其他不同形状的放射形切口1304 (仅此切口进行了编号W使图示清楚）。 Nan shows a series of circular radial cuts 1302 (a) to 1302 (f), a number of other different shapes radial cutout 1304 (numbered only incision W clarity of illustration). 运些放射形切口在一定程度上可W预见是W切片形式开创的。 These radial cuts transport to some extent can be expected W is W chips in the form pioneered. 还显示了一系列圆柱形切口1306(a)至1306(d)。 Also shows a series of cylindrical cut 1306 (a) to 1306 (d). 显示了囊切切口1308。 It shows the capsule-cut slit 1308.
[0112] 图14A和图14B分别显示了在同一激光照射图案下的晶状体的侧截面图和顶截面图。 [0112] FIGS. 14A and 14B show a side sectional view and a top sectional view of the lens of the laser irradiation in the same pattern. 图14C提供了晶状体和照射模式的预期视图。 Figure 14C provides a view of the illumination lens and the expected pattern. 因此，显示了晶状体囊1401。 Therefore, the display of the lens capsule 1401. 显示了一系列楠圆形放射形切口1402 (a)至1402 (f)，一系列球体切口1404 (仅此切口进行了编号W 使图示清楚）。 Nan shows a series of circular radial cuts 1402 (a) to 1402 (f), a series of spherical cutouts 1404 (only this cut-numbered W clarity of illustration). 显示了囊切切口1408。 It shows the capsule-cut slit 1408.
[0113] 图15A和图15B分别显示了在同一激光照射图案1508下的晶状体的侧截面图和顶截面图。 [0113] FIGS. 15A and 15B show a side sectional view of the same laser shot pattern 1508 at the top and cross-sectional view of the lens. 显示了晶状体囊1501。 1501 shows the lens capsule. 显示了一个激光照射图案或剖切模式1508,带有纵向1504和横向1505切口的网格模式（如图所示）。 Shows a laser irradiation pattern or cut pattern 1508, and 1504 in a grid pattern with a longitudinal lateral incision of 1505 (as shown). 运一照射模式导致晶状体切片为一系列细长的长方形条。 Illumination mode causes the lens to transport a slice of a series of elongated rectangular strips. 运些长条的形状大小刚好匹配或比用于摘除切片晶状体材料的抽吸管开口的大小略小一些。 The size of the opening of the suction tube transport more elongated shape than just the right size to match or removal of lens material slightly smaller slices. 因此，网格模式中的长方形条的大小是基于抽吸管开口的大小，目前范围在大约0. 4毫米至1毫米之间。 Thus, the size of a rectangular grid pattern strip is based on the size of the suction opening, the current range of between about 0.4 to 1 mm. 匹配网格模式中长方形条的大小的能力，和由照射模式向晶状体传送而创造的晶状体材料的长方形切段的大小，W及抽吸管开口的大小，都安全和有效地提高了在晶状体转换手术中摘取晶状体材料的能力。 Capability matching the size of a rectangular grid pattern of strips, cut into sections and the size of the rectangular lens material is irradiated by the lens delivery mode to be created, W, and size of the suction openings are safe and effective in improving the conversion lens the ability of the lens material removal surgery.
[0114] 图16A和图1她分别显示了在同一激光照射图案1608下的晶状体的侧截面图和顶截面图。 [0114] FIGS. 16A and FIG. 1 show her a side sectional view of the same laser irradiation pattern in the lens 1608 and a top cross-sectional view. 显示了晶状体囊1601。 1601 shows the lens capsule. 显示了一个激光照射图案或剖切模式1608,带有纵向1604和横向1605切口的网格模式（如图所示）。 Shows a laser irradiation pattern or cut pattern 1608, and 1604 in a grid pattern with a longitudinal lateral incision of 1605 (as shown). 运一照射模式导致晶状体切片为一系列细长的长方形条。 Illumination mode causes the lens to transport a slice of a series of elongated rectangular strips. 运些长条的形状大小刚好匹配或比用于摘除切片晶状体材料的抽吸管开口的大小略小一些。 The size of the opening of the suction tube transport more elongated shape than just the right size to match or removal of lens material slightly smaller slices. 因此，网格模式中的长方形条的大小是基于抽吸管开口的大小，目前范围在大约0. 4毫米至1毫米之间。 Thus, the size of a rectangular grid pattern strip is based on the size of the suction opening, the current range of between about 0.4 to 1 mm. 匹配网格模式中长方形条的大小的能力，和由照射模式向晶状体传送而创造的晶状体材料的长方形切段的大小，W及抽吸管开口的大小，都安全和有效地提高了在晶状体转换手术中摘取晶状体材料的能力。 Capability matching the size of a rectangular grid pattern of strips, cut into sections and the size of the rectangular lens material is irradiated by the lens delivery mode to be created, W, and size of the suction openings are safe and effective in improving the conversion lens the ability of the lens material removal surgery. 此图还进一步表明，分段材料的形状遵循晶状体前囊的形状。 This figure further shows that the material follows the shape of the segment of the anterior lens capsule shape.
[0115] 图17A和图17B分别显示了在同一激光照射图案1708下的晶状体的侧截面图和顶截面图。 [0115] FIGS. 17A and 17B show a side sectional view of the same laser shot pattern 1708 at the top and cross-sectional view of the lens. 显示了晶状体囊1701。 1701 shows the lens capsule. 显示了一个激光照射图案或剖切模式1708,带有圆形切口1704和球体类似形状1705的网格类似模式。 Shows a laser irradiation pattern or cut pattern 1708, the grid pattern similar to a sphere with a circular cutout 1704 and 1705 similarly shaped. 运一照射模式导致晶状体切片为一系列细长的长方形条。 Illumination mode causes the lens to transport a slice of a series of elongated rectangular strips. 运些长条的形状大小刚好匹配或比用于摘除切片晶状体材料的抽吸管开口的大小略小一些。 The size of the opening of the suction tube transport more elongated shape than just the right size to match or removal of lens material slightly smaller slices. 因此，网格模式中的长方形条的大小是基于抽吸管开口的大小，目前范围在大约0. 4毫米至1毫米之间。 Thus, the size of a rectangular grid pattern strip is based on the size of the suction opening, the current range of between about 0.4 to 1 mm. 匹配网格模式中长方形条的大小的能力，和由照射模式向晶状体传送而创造的晶状体材料的长方形切段的大小，W及抽吸管开口的大小，都安全和有效地提高了在晶状体转换手术中摘取晶状体材料的能力。 Capability matching the size of a rectangular grid pattern of strips, cut into sections and the size of the rectangular lens material is irradiated by the lens delivery mode to be created, W, and size of the suction openings are safe and effective in improving the conversion lens the ability of the lens material removal surgery. 此图还进一步表明，分段材料的形状遵循晶状体前囊的形状。 This figure further shows that the material follows the shape of the segment of the anterior lens capsule shape.
[0116] 从上述描述说明来看，本领域技术人员可W很容易地确定本发明的本质特征，同时并未背离其精神和范围，可使本发明拥有各种各样的变化和/或修改W适用于各种用途和条件。 [0116] From the description described above, the present W art can readily ascertain the essential characteristics of the invention, while not departing from the spirit and scope of the present invention can have a variety of variations and / or modifications W to various usages and conditions.
[0117] 因此，本发明在不背离其精神或本质特征的前提下，可W应用于除开本说明书中披露的其他具体实施方式中。 [0117] Accordingly, in the present invention without departing from its spirit or essential characteristics thereof, W can be applied to, among other specific embodiments disclosed in the specification of the format. 在此描述的具体实施方式仅为说明性质不具备限制性，本发明的范围与其附加的要求相当，并非上述描述说明。 DETAILED DESCRIPTION embodiments described herein are illustrative only and do not have the restrictive, the scope of the present invention and its appended claims rather, the above description is not described.
1. 一种在天然人眼晶状体上提供激光照射图案、以软化天然人眼晶状体的系统，该系统包括： a. 产生激光束的医用激光器； b. 用于剖切天然人眼晶状体的激光照射图案，其包括第一区域和第二区域； c. 所述激光照射图案之第一区域具有不同于所述激光照射图案之第二区域的照射和/或切口密度； d. 其中，当传输到天然人眼晶状体时，第一区域和第二区域的激光照射图案能提供一种具有不同软化度之区域的晶状体；以及e. 其中，第一区域的激光照射图案为一系列的放射形切口。 1. A method of providing a laser irradiation pattern on the natural human lens in order to soften the natural human lens system, the system comprising: a medical laser generating a laser beam; b. Laser irradiation taken for the natural human crystalline lens. pattern, which comprises a first region and a second region;. c of the first laser irradiation region having a pattern of illumination and / or the second region different from the slit density of the laser beam irradiation pattern;. d wherein, when transferred to when the natural human lens, the first laser irradiation region and the second region can provide a pattern having regions of different lens softening degrees; wherein e and the laser irradiation pattern of the first region is a series of radial cuts.
2. 如权利要求1所述的系统，其中，第一区域的照射量比第二区域的照射量更密。 2. The system according to claim 1, wherein the amount of irradiation of the second irradiation region than the first region is more dense.
3. 如权利要求1所述的系统，其中，第二区域的切口数量比第一区域的切口数量更密。 The system according to claim 1, wherein the number of cuts region is denser than the second number of cuts in the first region.
4. 如权利要求1所述的系统，其中，第二区域的激光照射图案包括创建体积形状的模式。 The system as claimed in claim 1, wherein the laser irradiation pattern of the second region comprises a volume creation mode shape.
5. 如权利要求1所述的系统，其中，第二区域的激光照射图案主要为剖切的体积形状。 5. The system according to claim 1, wherein the pattern of the second laser irradiation region as taken in the main volumetric shapes.
6. 如权利要求5所述的系统，其中，所述体积形状主要为立方体。 The system as claimed in claim 5, wherein said shape is cuboid volume.
7. 如权利要求5所述的系统，其中，所述体积形状主要为管状体。 7. The system according to claim 5, wherein the shape of the main volume of the tubular body.
8. 如权利要求5所述的系统，其中，所述体积形状主要为球状体。 The system as claimed in claim 5, wherein the main volume of the spheroid shape.
9. 如权利要求5所述的系统，其中，所述体积形状包括管状体。 9. The system according to claim 5, wherein the volume of said tubular body comprises a shape.
10. -种在天然人眼晶状体上提供激光照射图案、以差别化地软化天然人眼晶状体的系统，该系统包括： a. 产生激光束的医用激光器； b. 用于剖切天然人眼晶状体的激光照射图案，其包括第一、第二和第三区域； c. 第一、第二和第三区域的每一个主要由体积形状构成； d. 第一、第二和第三区域中的至少两个具有不同密度的体积形状； e. 其中，当传输到天然人眼晶状体时，第一、第二和第三区域中的至少两个能提供具有不同软化度的晶状体材料；以及f. 其中，至少一种体积形状在其所在区域的形状对应于抽吸针形状。 10. The - method of providing a laser irradiation pattern on the natural human lens in order to soften the natural human crystalline lens system differentiated, the system comprising: a medical laser generating a laser beam; b. A cut natural human crystalline lens. the laser irradiation pattern, which comprises a first, second and third areas;. c first, second and third region each consists essentially of volumetric shapes;. d of the first, second, and third regions shape having a volume of at least two different densities;. e wherein, when transmitting to the natural human lens, the first, second, and providing at least two lens materials having different degrees of softening the third region; and f. wherein at least one of its volume of shape corresponding to the shape in the region of the suction needle shape.
11. 如权利要求10所述的系统，其中，所述的系统包括用于进行囊切的照射图案。 11. The system according to claim 10, wherein said system comprises an irradiation pattern for cutting the balloon.
12. 如权利要求11所述的系统，其中，第一区域的照射和/或切口密度大于第二区域的照射和/或切口密度，第二区域的照射和/或切口密度大于第三区域的照射和/或切口密度。 12. The system of claim 11, wherein the irradiation and / or density of the first region is greater than the cut-irradiation and / or density of the second region of the cutout, irradiation and / or second cut-density region is greater than the third region irradiation and / or cut density.
13. -种在天然人眼晶状体上提供激光照射图案、以差别化地软化天然人眼晶状体的系统，该系统包括： a. 产生激光束的医用激光器； b. 用于剖切天然人眼晶状体的激光照射图案，其包括第一、第二和第三区域； c. 第一、第二和第三区域中的至少两个具有不同照射密度； d. 其中，当传输到天然人眼晶状体时，第一、第二和第三区域中的至少两个能提供具有不同软化度的晶状体材料；以及e. 其中，第一区域的激光照射图案为一系列的放射形切口。 13. The - method of providing a laser irradiation pattern on the natural human lens in order to soften the natural human crystalline lens system differentiated, the system comprising: a medical laser generating a laser beam; b. A cut natural human crystalline lens. the laser irradiation pattern, which comprises a first, second and third areas;. c of the first, second, and third regions of the at least two different irradiation density;. d wherein, when the transmission to the natural human crystalline lens when first, second and third regions of the at least two lens material to provide different softness; and e wherein, a laser irradiation pattern of the first region is a series of radial cuts.
14. 如权利要求13所述的系统，其中，第二和第三区域中的至少一个的形状是基于吸出管的形状。 14. The system according to claim 13, wherein the shape of the second and third regions form the at least one draft tube is based.
15. 如权利要求13所述的系统，其中，所述的系统包括用于进行囊切的照射图案。 15. The system according to claim 13, wherein said system comprises an irradiation pattern for cutting the balloon.
16. -种在天然人眼晶状体上提供激光照射图案的系统，该系统包括： a. 产生激光束的激光器； b. 与照射图案相关的控制器； c. 照射图案中包括能够在天然人眼晶状体上产生不同照射和/或切口密度的第一区域和第二区域的模式； d. 第一区域对应于用于摘除晶状体材料的吸出针； e. 其中，第一区域能提供从眼睛中吸出晶状体材料；以及f. 其中，第一区域的激光照射图案为一系列的放射形切口。 16. - The system of laser irradiation method of providing a pattern on the natural human lens, the system comprising: a laser generating a laser beam; b. A controller associated with the illumination pattern; C can be included in the irradiation pattern of native human eye... generating different illumination and / or the mode of the first and second regions of the slit density on the lens;. d corresponding to a first region for removal of the lens material is aspirated needle;. e wherein the first region provides aspirated from the eye lens material; and f wherein a laser irradiation pattern of the first region is a series of radial cuts.
17. 如权利要求16所述的系统，其中，所述的控制器与囊切的照射图案相关。 17. The system according to claim 16, wherein said controller is associated with the irradiation pattern capsulotomy.
18. -种在天然人眼晶状体上提供激光照射图案、以软化和润滑天然人眼晶状体切片的系统，该系统包括： a. 产生激光束的医用激光器； b. 用于进行囊切的激光照射图案； c. 用于剖切天然人眼晶状体的激光照射图案； d. 激光照射图案包括第一区域和第二区域； e. 激光照射图案的第一区域具有不同于激光照射图案之第二区域的照射和/或切口密度； f. 其中，当传输到天然人眼晶状体时，激光照射图案的第一区域或激光照射图案的第二区域能提供软化和润滑的晶状体材料，以便于其更容易地除去；以及g. 其中，第一区域的激光照射图案为一系列的放射形切口，且放射形切口之间开创多个球体切口。 18. The - method of providing a laser irradiation pattern on the natural human lens to soften and lubricate the natural human crystalline lens slice system, the system comprising: a medical laser generating a laser beam; b. A laser irradiation capsulotomy. pattern;. c for the laser illumination pattern taken of the natural human lens; D laser irradiation pattern includes a first region and a second region;.. e first laser irradiation region has a different pattern of laser irradiation pattern of the second region irradiation and / or cut density;. f wherein, when transmitting to the natural human lens, the first region or the second region of the laser irradiation pattern of laser irradiation pattern can provide softening and lubricating the lens material, it is easier to removed; g, and wherein the laser irradiation pattern of the first region is a series of radial cuts, incisions between the sphere and create a plurality of radial cuts.
19. 一种在天然人眼晶状体上提供剖切天然人眼晶状体的激光照射图案、以软化和润滑天然人眼晶状体切片的系统，该系统包括： a. 用于产生激光束的医用激光器； b. 用于进行囊切的激光照射图案； c. 用于剖切天然人眼晶状体的激光照射图案，其包括第一区域和第二区域； d. 激光照射图案的第一区域具有不同于其第二区域的照射和/或切口密度；以及e. 其中，当发送到天然人眼晶状体时，第一区域和第二区域的照射图案能在晶状体上形成具有不同软化程度的区域； e、其中，第一区域的激光照射图案为一系列的放射形切口。 19. A method of providing a natural human lens in a laser irradiation pattern cut natural human crystalline lens, to soften and lubricate the natural human crystalline lens sections system, the system comprising:. A therapeutic laser for producing a laser beam; b. . capsulotomy for laser shot pattern; C for a laser irradiation pattern taken of the natural human lens, comprising a first region and a second region;.. D the first laser irradiation region has a different pattern on its irradiation and / or density of the second region of the notch; and e wherein, when transmitting to the natural human lens, a first region and a second region of the irradiation pattern can be formed of regions having different softening degree in the lens;. e, wherein, a laser irradiation pattern of the first region is a series of radial cuts.
20. -种在天然人眼晶状体上提供激光照射图案、以差别化地软化天然人眼晶状体的系统，该系统包括： a. 用于产生激光束的医用激光器； b. 用于剖切天然人眼晶状体的激光照射图案，其包括第一模式和第二模式； c. 第一模式包括在天然人眼晶状体上创建若干放射形切口的若干激光照射； d. 第二模式包括创建若干圆柱形切口的若干激光照射；以及e.其中，所述的圆柱形切口同轴地位于所述放射形切口的区域。 20. The - method of providing a laser irradiation pattern on the natural lens of the eye, the natural human lens in order to soften the differentiated system, the system comprising: a medical laser for generating a laser beam; b. A native human cutaway. laser irradiation pattern intraocular lens, comprising a first and second modes;. C mode comprises a first plurality of laser shots to create a plurality of radial cuts in the natural human lens; D model includes creating a plurality of second cylindrical cut. several laser irradiation;. e, and wherein said cylindrical slit-shaped cutout region located coaxially of the radiation.
21. 如权利要求20所述的系统，其中，所述的放射形切口具有共同的第一圆心，所述的圆柱形切口是同轴的，且具有共同的第二圆心。 21. The system according to claim 20, wherein said radial cuts having a common first center, said cylindrical cutout are coaxial, and have a common second center.
22. 如权利要求21所述的系统，其中，所述的圆柱形切口同轴地位于所述放射形切口的区域，而且第一圆心和第二圆心基本上是吻合的。 22. The system according to claim 21, wherein said cylindrical-shaped cutout cutout region located coaxially of the radiation, and the first and second central substantially consistent.
23. 如权利要求22所述的系统，其中，在最靠近该共同的圆心的那个圆柱形切口所限定的区域中，不存在若干放射形切口。 23. The system according to claim 22, wherein, in the cylindrical cut closest to the area defined by the common center, there is a plurality of radial cuts.
CN201080042744.XA 2009-07-24 2010-07-23 A method of providing a system and method for a laser irradiation pattern of the eye lens CN102647954B (en)
CN102647954A CN102647954A (en) 2012-08-22
CN102647954B true CN102647954B (en) 2016-02-03
CN201080042744.XA CN102647954B (en) 2009-07-24 2010-07-23 A method of providing a system and method for a laser irradiation pattern of the eye lens
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