Source: http://www.google.com/patents/US7976836?dq=5,815,488
Timestamp: 2016-02-07 04:19:15
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Matched Legal Cases: ['Application No. 10183435', 'Application No. 10183252', 'Application No. 10182195', 'Application No. 10182243', 'Application No. 10182362', 'Application No. 10182485', 'Application No. 10183301', 'Application No. 10182433', 'Application No. 10183378', 'Application No. 10182303']

Patent US7976836 - Treatment of stroke using placental stem cells - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThe present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta,...http://www.google.com/patents/US7976836?utm_source=gb-gplus-sharePatent US7976836 - Treatment of stroke using placental stem cellsAdvanced Patent SearchPublication numberUS7976836 B2Publication typeGrantApplication numberUS 12/341,961Publication dateJul 12, 2011Filing dateDec 22, 2008Priority dateDec 6, 2000Fee statusPaidAlso published asCA2430989A1, CA2678490A1, EP1349918A1, EP1349918A4, EP1349918B1, EP2206772A2, EP2206772A3, EP2305795A1, EP2322601A1, US7045148, US7638141, US8293223, US8545833, US8580563, US8986984, US9149569, US20020123141, US20050272148, US20090053805, US20090142831, US20100120015, US20110217271, US20110217272, US20110223141, US20120020936, US20120058089, US20140349391, US20150175959, WO2002046373A1, WO2002046373A8, WO2002046373A9Publication number12341961, 341961, US 7976836 B2, US 7976836B2, US-B2-7976836, US7976836 B2, US7976836B2InventorsRobert J. HaririOriginal AssigneeAnthrogenesis CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (267), Non-Patent Citations (192), Referenced by (44), Classifications (59), Legal Events (2) External Links: USPTO, USPTO Assignment, EspacenetTreatment of stroke using placental stem cells
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3862002Jul 3, 1967Jan 21, 1975Sanfar Lab IncProduction of physiologically active placental substancesUS4829000May 27, 1986May 9, 1989The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesReconstituted basement membrane complex with biological activityUS5004681Nov 12, 1987Apr 2, 1991Biocyte CorporationPreservation of fetal and neonatal hematopoietic stem and progenitor cells of the bloodUS5192553Nov 10, 1988Mar 9, 1993Biocyte CorporationIsolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic useUS5197985Nov 16, 1990Mar 30, 1993Caplan Arnold IMethod for enhancing the implantation and differentiation of marrow-derived mesenchymal cellsUS5226914Nov 16, 1990Jul 13, 1993Caplan Arnold IMethod for treating connective tissue disordersUS5272071Dec 21, 1990Dec 21, 1993Applied Research Systems Ars Holding N.V.Method for the modification of the expression characteristics of an endogenous gene of a given cell lineUS5356373Nov 15, 1991Oct 18, 1994Miles Inc.Method and apparatus for autologous transfusions in premature infantsUS5372581Jul 21, 1993Dec 13, 1994Minneapolis Children's Services CorporationMethod and apparatus for placental blood collectionUS5415665Jan 26, 1993May 16, 1995Utah Medical Products, Inc.Umbilical cord clamping, cutting, and blood collecting device and methodUS5437994Dec 10, 1993Aug 1, 1995Regents Of The University Of MichiganMethod for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cellsUS5460964Mar 17, 1993Oct 24, 1995Regents Of The University Of MinnesotaMethod for culturing hematopoietic cellsUS5464764Feb 4, 1993Nov 7, 1995University Of Utah Research FoundationPositive-negative selection methods and vectorsUS5486359Feb 8, 1994Jan 23, 1996Osiris Therapeutics, Inc.Human mesenchymal stem cellsUS5487992Jun 28, 1993Jan 30, 1996University Of Utah Research FoundationCells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making sameUS5516532Aug 5, 1994May 14, 1996Children's Medical Center CorporationInjectable non-immunogenic cartilage and bone preparationUS5591625Nov 24, 1993Jan 7, 1997Case Western Reserve UniversityTransduced mesenchymal stem cellsUS5605822Dec 1, 1994Feb 25, 1997The Regents Of The University Of MichiganMethods, compositions and devices for growing human hematopoietic cellsUS5627059Jun 5, 1995May 6, 1997University Of UtahCells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making sameUS5635386Nov 2, 1994Jun 3, 1997The Regents Of The University Of MichiganMethods for regulating the specific lineages of cells produced in a human hematopoietic cell cultureUS5635387Apr 3, 1995Jun 3, 1997Cellpro, Inc.Methods and device for culturing human hematopoietic cells and their precursorsUS5643741Jun 6, 1995Jul 1, 1997Systemix, Inc.Identification and isolation of human hematopoietic stem cellsUS5646043Mar 10, 1995Jul 8, 1997Regents Of The University Of MichiganMethods for the ex vivo replication of human stem cells and/or expansion of human progenitor cellsUS5654186Feb 26, 1993Aug 5, 1997The Picower Institute For Medical ResearchBlood-borne mesenchymal cellsUS5654381Jun 16, 1995Aug 5, 1997Massachusetts Institute Of TechnologyFunctionalized polyester graft copolymersUS5665557Nov 14, 1994Sep 9, 1997Systemix, Inc.Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereofUS5668104Mar 31, 1993Sep 16, 1997Toray Industries, Inc.Hematopoietic stem cell growth-promoting compositions containing a fibroblast-derived fragment of fibronectin and a growth factor, and methods employing them in vitro or in vivoUS5670147Dec 1, 1994Sep 23, 1997Regents Of The University Of MichiganCompositions containing cultured mitotic human stem cellsUS5670351Dec 30, 1994Sep 23, 1997The Regents Of The University Of MichiganMethods and compositions for the ex vivo replication of human hematopoietic stem cellsUS5672346Jun 15, 1993Sep 30, 1997Indiana University FoundationHuman stem cell compositions and methodsUS5709854Apr 30, 1993Jan 20, 1998Massachusetts Institute Of TechnologyTissue formation by injecting a cell-polymeric solution that gels in vivoUS5716616Mar 28, 1995Feb 10, 1998Thomas Jefferson UniversityIsolated stromal cells for treating diseases, disorders or conditions characterized by bone defectsUS5716794Mar 29, 1996Feb 10, 1998Xybernaut CorporationCeliac antigenUS5716827Jun 6, 1995Feb 10, 1998Systemix, Inc.Human hematopoietic stem cellUS5733541Apr 21, 1995Mar 31, 1998The Regent Of The University Of MichiganHematopoietic cells: compositions and methodsUS5733542Jan 24, 1995Mar 31, 1998Haynesworth; Stephen E.Enhancing bone marrow engraftment using MSCSUS5736396Jan 24, 1995Apr 7, 1998Case Western Reserve UniversityLineage-directed induction of human mesenchymal stem cell differentiationUS5744361Jun 6, 1995Apr 28, 1998Indiana UniversityExpansion of human hematopoietic progenitor cells in a liquid mediumUS5750397Jun 6, 1995May 12, 1998Systemix, Inc.Human hematopoietic stem cellUS5763197Jun 25, 1991Jun 9, 1998Systemix, Inc.Human hematopoietic stem cellUS5763266Mar 4, 1993Jun 9, 1998The Regents Of The University Of MichiganMethods, compositions and devices for maintaining and growing human stem and/or hematopoietics cellsUS5807686Jun 6, 1995Sep 15, 1998Regents Of University Of MinnesotaPluripotential quiescent stem cell populationUS5811094Apr 11, 1995Sep 22, 1998Osiris Therapeutics, Inc.Connective tissue regeneration using human mesenchymal stem cell preparationsUS5827735May 20, 1996Oct 27, 1998Morphogen Pharmaceuticals, Inc.Pluripotent mesenchymal stem cells and methods of use thereofUS5827740Jul 30, 1996Oct 27, 1998Osiris Therapeutics, Inc.Adipogenic differentiation of human mesenchymal stem cellsUS5827742Sep 1, 1994Oct 27, 1998Beth Israel Deaconess Medical Center, Inc.Method of selecting pluripotent hematopioetic progenitor cellsUS5837539Jun 2, 1995Nov 17, 1998Osiris Therapeutics, Inc.Monoclonal antibodies for human mesenchymal stem cellsUS5849553Jun 7, 1995Dec 15, 1998California Institute Of TechnologyMammalian multipotent neural stem cellsUS5851984Aug 16, 1996Dec 22, 1998Genentech, Inc.Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptidesUS5855619Sep 30, 1996Jan 5, 1999Case Western Reserve UniversityBiomatrix for soft tissue regenerationUS5858782Nov 13, 1995Jan 12, 1999Regents Of The University Of MichiganFunctional human hematopoietic cellsUS5861315Oct 16, 1996Jan 19, 1999Amgen Inc.Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cellsUS5866414Sep 19, 1995Feb 2, 1999Badylak; Stephen F.Submucosa gel as a growth substrate for cellsUS5874301Dec 11, 1995Feb 23, 1999National Jewish Center For Immunology And Respiratory MedicineEmbryonic cell populations and methods to isolate such populationsUS5877299Jun 16, 1995Mar 2, 1999Stemcell Technologies Inc.Methods for preparing enriched human hematopoietic cell preparationsUS5879318Aug 18, 1997Mar 9, 1999Npbi International B.V.Method of and closed system for collecting and processing umbilical cord bloodUS5879940May 23, 1997Mar 9, 1999Fred Hutchinson Cancer Research CenterHuman marrow stromal cell lines which sustain hematopoiesesUS5905041Jun 28, 1995May 18, 1999Boehringer Ingelheim International GmbhProcess for preparing and cultivating hematopoietic progenitor cellsUS5906934Mar 14, 1995May 25, 1999Morphogen Pharmaceuticals, Inc.Mesenchymal stem cells for cartilage repairUS5908782Jun 5, 1995Jun 1, 1999Osiris Therapeutics, Inc.Chemically defined medium for human mesenchymal stem cellsUS5908784Nov 15, 1996Jun 1, 1999Case Western Reserve UniversityIn vitro chondrogenic induction of human mesenchymal stem cellsUS5914108Jun 6, 1995Jun 22, 1999Systemix, Inc.Human hematopoietic stem cellUS5914268Nov 21, 1994Jun 22, 1999National Jewish Center For Immunology & Respiratory MedicineEmbryonic cell populations and methods to isolate such populationsUS5916202Aug 30, 1996Jun 29, 1999Haswell; John N.Umbilical cord blood collectionUS5919176Oct 30, 1996Jul 6, 1999Children's Hospital Medical Center Of Northern CaliforniaApparatus and method for collecting blood from an umbilical cordUS5919702Oct 23, 1996Jul 6, 1999Advanced Tissue Science, Inc.Production of cartilage tissue using cells isolated from Wharton's jellyUS5922597Nov 13, 1996Jul 13, 1999Regents Of The University Of MinnesotaEx vivo culture of stem cellsUS5925567Oct 6, 1997Jul 20, 1999T. Breeders, Inc.Selective expansion of target cell populationsUS5928214Aug 3, 1998Jul 27, 1999New York Blood Center, Inc.High concentration white cells, a method for agglomeration of the high concentration and a bag set for use in conjunction therewithUS5928947Jun 7, 1995Jul 27, 1999California Institute Of TechnologyMammalian multipotent neural stem cellsUS5942225Jul 23, 1997Aug 24, 1999Case Western Reserve UniversityLineage-directed induction of human mesenchymal stem cell differentiationUS5942496Sep 30, 1994Aug 24, 1999The Regent Of The University Of MichiganMethods and compositions for multiple gene transfer into bone cellsUS5958767Aug 14, 1998Sep 28, 1999The Children's Medical Center Corp.Engraftable human neural stem cellsUS5962325Sep 18, 1998Oct 5, 1999Advanced Tissue Sciences, Inc.Three-dimensional stromal tissue culturesUS5968829Sep 5, 1997Oct 19, 1999Cytotherapeutics, Inc.Human CNS neural stem cellsUS5969105Oct 21, 1997Oct 19, 1999Feng; YiqingStem cell factor receptor agonistsUS5993429May 14, 1997Nov 30, 1999Childen's Hospital Medical Center Of Northern CaliforniaApparatus and method for collecting blood from an umbilical cordUS5997860Nov 15, 1995Dec 7, 1999G. D. Searle & Co.Ex-vivo expansion of stem cells using combinations of interleukin-3 (IL-3) variants and other cytokinesUS6001654Apr 25, 1997Dec 14, 1999California Institute Of TechnologyMethods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factorsUS6010696Mar 25, 1998Jan 4, 2000Osiris Therapeutics, Inc.Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cellsUS6011000Jun 6, 1995Jan 4, 2000Perrine; Susan P.Compositions for the treatment of blood disordersUS6020469Apr 15, 1999Feb 1, 2000Amgen Inc.Stem cell factor formulations and methodsUS6022540Aug 28, 1998Feb 8, 2000Osiris Therapeutics, Inc.Ligands that modulate differentiation of mesenchymal stem cellsUS6022743Mar 8, 1999Feb 8, 2000Advanced Tissue Sciences, Inc.Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitroUS6022848Sep 30, 1994Feb 8, 2000Pro-Neuron, Inc.Inhibitor of stem cell proliferation and uses thereofUS6030836Jun 8, 1999Feb 29, 2000Osiris Therapeutics, Inc.Vitro maintenance of hematopoietic stem cellsUS6057123Dec 23, 1992May 2, 2000British Biotech Pharmaceuticals LimitedStem cell inhibiting proteinsUS6059968Jan 20, 1998May 9, 2000Baxter International Inc.Systems for processing and storing placenta/umbilical cord bloodUS6077708Sep 24, 1998Jun 20, 2000Collins; Paul C.Method of determining progenitor cell content of a hematopoietic cell cultureUS6087113May 19, 1998Jul 11, 2000Case Western Reserve UniversityMonoclonal antibodies for human mesenchymal stem cellsUS6093531Jun 19, 1998Jul 25, 2000Neurospheres Holdings Ltd.Generation of hematopoietic cells from multipotent neural stem cellsUS6110739Feb 22, 1999Aug 29, 2000National Jewish Medical And Research CenterMethod to produce novel embryonic cell populationsUS6127135May 27, 1998Oct 3, 2000Hill; Beth LouiseMethods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereofUS6146888Apr 21, 1994Nov 14, 2000The University Of EdinburghMethod of enriching for mammalian stem cellsUS6174333Dec 29, 1998Jan 16, 2001Osiris Therapeutics, Inc.Biomatrix for soft tissue regeneration using mesenchymal stem cellsUS6179819Sep 9, 1999Jan 30, 2001John N. HaswellUmbilical cord blood collectionUS6184035Nov 18, 1998Feb 6, 2001California Institute Of TechnologyMethods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cellsUS6190368May 12, 1999Feb 20, 2001Children's Hospital Medical Center Of Northern CaliforniaApparatus and method for collecting blood from an umbilical cordUS6214369May 6, 1999Apr 10, 2001Morphogen Pharmaceuticals, Inc.Mesenchymal stem cells for cartilage repairUS6224860Apr 15, 1999May 1, 2001Quality Biological, Inc.Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free mediumUS6225119May 21, 1999May 1, 2001Osiris Therapeutics, Inc.Production of megakaryocytes by the use of human mesenchymal stem cellsUS6227202Aug 29, 1997May 8, 2001Maulana Azad Medical CollegeMethod of organogenesis and tissue regeneration/repair using surgical techniquesUS6231880May 29, 1998May 15, 2001Susan P. PerrineCompositions and administration of compositions for the treatment of blood disordersUS6239157Sep 10, 1999May 29, 2001Osiris Therapeutics, Inc.Inhibition of osteoclastogenesisUS6248587Nov 24, 1998Jun 19, 2001University Of Southern CailforniaMethod for promoting mesenchymal stem and lineage-specific cell proliferationUS6251383Jun 24, 1999Jun 26, 2001National Institute Of ImmunologyMethod for ex-vivo expansion of hematopoietic cellsUS6255112Jun 8, 1999Jul 3, 2001Osiris Therapeutics, Inc.Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cellsUS6261549Jul 1, 1998Jul 17, 2001Osiris Therapeutics, Inc.Human mesenchymal stem cells from peripheral bloodUS6280718Nov 8, 1999Aug 28, 2001Wisconsin Alumni Reasearch FoundationHematopoietic differentiation of human pluripotent embryonic stem cellsUS6281012May 1, 2000Aug 28, 2001Osiris Therapeutics, Inc.Method of preparing suppressor T cells with allogeneic mesenchymal stem cellsUS6300314May 3, 1999Oct 9, 2001Point Therapeutics, Inc.Hematopoietic stimulationUS6306575Dec 1, 1995Oct 23, 2001Stemcell Technologies, Inc.Methods for preparing enriched human hematopoietic cell preparationsUS6312950Sep 14, 1999Nov 6, 2001Terumo Kabushiki KaishaApparatus and method for isolating and recovering cellsUS6322784Oct 26, 1998Nov 27, 2001Osiris Therapeutics, Inc.Adipogenic differentiation of human mesenchymal stem cellsUS6326019Jul 25, 2000Dec 4, 2001Scheffer C. G. TsengGrafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeriesUS6326198Feb 11, 1997Dec 4, 2001Regents Of The University Of MichiganMethods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cellsUS6328765Dec 3, 1998Dec 11, 2001Gore Enterprise Holdings, Inc.Methods and articles for regenerating living tissueUS6328960Mar 12, 1999Dec 11, 2001Osiris Therapeutics, Inc.Mesenchymal stem cells for prevention and treatment of immune responses in transplantationUS6335195Jan 23, 1998Jan 1, 2002Maret CorporationMethod for promoting hematopoietic and mesenchymal cell proliferation and differentiationUS6337387Nov 15, 1996Jan 8, 2002Asahi Kasei Kabushiki KaishaDifferentiation-suppressive polypeptideUS6338942Apr 12, 1999Jan 15, 2002T. Breeders, Inc.Selective expansion of target cell populationsUS6355239Mar 12, 1999Mar 12, 2002Osiris Therapeutics, Inc.Uses for non-autologous mesenchymal stem cellsUS6368636Oct 26, 1999Apr 9, 2002Osiris Therapeutics, Inc.Mesenchymal stem cells for prevention and treatment of immune responses in transplantationUS6379953Dec 1, 1999Apr 30, 2002Osiris Therapeutics, Inc.Ligands that modulate differentiation of mesenchymal stem cellsUS6387367May 28, 1999May 14, 2002Osiris Therapeutics, Inc.Human mesenchymal stem cellsUS6387369Jul 14, 1998May 14, 2002Osiris Therapeutics, Inc.Cardiac muscle regeneration using mesenchymal stem cellsUS6461645May 16, 1990Oct 8, 2002Pharmastem Therapeutics, Inc.Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the bloodUS6497875Apr 24, 1997Dec 24, 2002Case Western Reserve UniversityMultilayer skin or dermal equivalent having a layer containing mesenchymal stem cellsUS6528245 *May 7, 1999Mar 4, 2003University Of South FloridaBone marrow cells as a source of neurons for brain and spinal cord repairUS6541024Mar 13, 1998Apr 1, 2003Osiris Therapeutics, Inc.Regeneration and augmentation of bone using mesenchymal stem cellsUS6685936Oct 12, 1999Feb 3, 2004Osiris Therapeutics, Inc.Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantationUS6709864Mar 28, 2000Mar 23, 2004Osiris Therapeutics, Inc.Adipogenic differentiation of human mesenchymal stem cellsUS6797269Mar 12, 1999Sep 28, 2004Osiris Therapeutics, Inc.Mesenchymal stem cells as immunosuppressantsUS6835377May 13, 1998Dec 28, 2004Osiris Therapeutics, Inc.Osteoarthritis cartilage regenerationUS6863900Jun 26, 2002Mar 8, 2005Osiris Therapeutics, Inc.Regeneration and augmentation of bone using mesenchymal stem cellsUS6875430Nov 13, 2001Apr 5, 2005Osiris Therapeutics, Inc.Mesenchymal stem cells for prevention and treatment of immune responses in transplantationUS7029666Jan 14, 2002Apr 18, 2006Osiris Therapeutics, Inc.Uses for non-autologous mesenchymal stem cellsUS7045148Dec 5, 2001May 16, 2006Anthrogenesis CorporationMethod of collecting placental stem cellsUS7244759Jul 28, 2004Jul 17, 2007Celgene CorporationIsoindoline compounds and methods of making and using the sameUS7255879Aug 12, 2003Aug 14, 2007Anthrogenesis CorporationPost-partum mammalian placenta, its use and placental stem cells therefromUS7311904Feb 13, 2002Dec 25, 2007Anthrogenesis CorporationTissue matrices comprising placental stem cells, and methods of making the sameUS7311905 *Feb 13, 2003Dec 25, 2007Anthrogenesis CorporationEmbryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cellsUS7468276 *Jun 22, 2004Dec 23, 2008Anthrogenesis CorporationPlacental stem cellsUS7638141Jul 21, 2005Dec 29, 2009Anthrogenesis CorporationIsolated placental perfusate and placental cells isolated therefromUS7642091Jan 5, 2010Jau-Nan LeeHuman trophoblast stem cells and use thereofUS7682803Mar 23, 2010Anthrogenesis CorporationImmunomodulation using placental stem cellsUS7700090 *Dec 28, 2006Apr 20, 2010Anthrogenesis CorporationCo-culture of placental stem cells and stem cells from a second sourceUS7875272Jan 25, 2011Ethicon, IncorporatedTreatment of stroke and other acute neuraldegenerative disorders using postpartum derived cellsUS7875273Dec 22, 2005Jan 25, 2011Ethicon, IncorporatedTreatment of Parkinson's disease and related disorders using postpartum derived cellsUS7909806Dec 5, 2007Mar 22, 2011Anthrogenesis CorporationCord blood and placenta collection kitUS7914779Oct 29, 2007Mar 29, 2011Anthrogenesis CorporationTissue matrices comprising placental stem cells, and methods of making the sameUS20010005591Feb 9, 2001Jun 28, 2001Osiris Therapeutics, Inc.Production of megakaryocytes by the use of human mesenchymal stem cellsUS20020102239Jul 6, 1998Aug 1, 2002Jan KoopmansMethods for storing neural cells such that they are suitable for transplantationUS20020123141Dec 5, 2001Sep 5, 2002Hariri Robert J.Method of collecting placental stem cellsUS20020132343Mar 6, 2002Sep 19, 2002Clark LumSystem and method for delivering umbilical cord-derived tissue-matched stem cells for transplantationUS20020160510Feb 13, 2002Oct 31, 2002Hariri Robert J.Renovation and repopulation of decellularized tissues and cadaveric organs by stem cellsUS20030032179Feb 13, 2002Feb 13, 2003Hariri Robert J.Post-partum mammalian placenta, its use and placental stem cells therefromUS20030044977Jul 30, 2002Mar 6, 2003Norio SakuragawaHuman stem cells originated from human amniotic mesenchymal cell layerUS20030180269Feb 13, 2003Sep 25, 2003Hariri Robert J.Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cellsUS20030235563Apr 21, 2003Dec 25, 2003Strom Stephen C.Placental derived stem cells and uses thereofUS20030235909Apr 11, 2003Dec 25, 2003Hariri Robert J.Modulation of stem and progenitor cell differentiation, assays, and uses thereofUS20040018617Nov 4, 2002Jan 29, 2004Shiaw-Min HwangSomatic pluripotent cellsUS20040028660May 30, 2003Feb 12, 2004Anthrogenesis CorporationMethods of using JNK or MKK inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromesUS20040048372Aug 12, 2003Mar 11, 2004Anthrogenesis CorporationPost-partum mammalian placenta, its use and placental stem cells therefromUS20040048796Mar 26, 2003Mar 11, 2004Hariri Robert J.Collagen biofabric and methods of preparation and use thereforUS20040107453Feb 14, 2002Jun 3, 2004Furcht Leo TMultipotent adult stem cells, sources thereof, methods of obtaining same, methods of differentiation thereof, methods of use thereof and cells derived thereofUS20040136967Aug 25, 2003Jul 15, 2004Kansas State University Research FoundationCultures, products and methods using stem cellsUS20040161419Oct 22, 2003Aug 19, 2004Strom Stephen C.Placental stem cells and uses thereofUS20040171147Nov 25, 2003Sep 2, 2004Hariri Robert J.Cytotherapeutics, cytotherapeutic units and methods for treatments using themUS20040180040Mar 14, 2003Sep 16, 2004Phillips Catherine A.Methods and compositions for directing cells to target organsUS20040219136Feb 13, 2004Nov 4, 2004Hariri Robert JUse of umbilical cord blood to treat individuals having a disease, disorder or conditionUS20040229351Jul 31, 2003Nov 18, 2004Anne-Marie RodriguezStem cells from adipose tissue, and differentiated cells from said cellsUS20050019865Jun 25, 2004Jan 27, 2005Kihm Anthony J.Cartilage and bone repair and regeneration using postpartum-derived cellsUS20050032209Jun 25, 2004Feb 10, 2005Messina Darin J.Regeneration and repair of neural tissue using postpartum-derived cellsUS20050037491Jun 25, 2004Feb 17, 2005Sanjay MistryRepair and regeneration of ocular tissue using postpartum-derived cellsUS20050042595Aug 13, 2004Feb 24, 2005Martin HaasBanking of multipotent amniotic fetal stem cellsUS20050054093Aug 13, 2004Mar 10, 2005Martin HaasMultipotent amniotic fetal stem cellsUS20050054098Jun 25, 2004Mar 10, 2005Sanjay MistryPostpartum cells derived from umbilical cord tissue, and methods of making and using the sameUS20050058629Jun 25, 2004Mar 17, 2005Harmon Alexander M.Soft tissue repair and regeneration using postpartum-derived cellsUS20050058630Jun 25, 2004Mar 17, 2005Harris Ian RossPostpartum-derived cells for use in treatment of disease of the heart and circulatory systemUS20050058631Jun 25, 2004Mar 17, 2005Kihm Anthony J.Postpartum cells derived from placental tissue, and methods of making and using the sameUS20050074435Dec 20, 2002Apr 7, 2005Robert CasperCellular compositions and methods of making and using themUS20050085543Dec 7, 2004Apr 21, 2005Synthes UsaMethods of treating bone or cartilage conditions by the administration of creatineUS20050089513Aug 17, 2004Apr 28, 2005Norio SakuragawaSide population cells originated from human amnion and their usesUS20050112104Oct 21, 2003May 26, 2005Pittenger Mark F.Cardiac muscle regeneration using mesenchymal stem cellsUS20050118715Apr 11, 2003Jun 2, 2005Hariri Robert J.Modulation of stem and progenitor cell differentiation, assays, and uses thereofUS20050124003Nov 15, 2002Jun 9, 2005Anthony AtalaMethods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereofUS20050143420Dec 2, 2004Jun 30, 2005Moutouh-De Parseval LaureMethods and compositions for the treatment and management of hemoglobinopathy and anemiaUS20050148034Apr 14, 2003Jul 7, 2005Hariri Robert J.Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compoundsUS20050148074Oct 8, 2004Jul 7, 2005Davies John E.Progenitor cells from wharton's jelly of human umbilical cordUS20050176139Jan 11, 2005Aug 11, 2005Yao-Chang ChenPlacental stem cell and methods thereofUS20050181502Mar 21, 2005Aug 18, 2005Athersys, Inc.Multipotent adult stem cells and methods for isolationUS20050186182Nov 10, 2004Aug 25, 2005Theresa DeisherMethods of using G-CSF mobilized C-Kit+ cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathyUS20050233452Feb 10, 2005Oct 20, 2005Neuronyx, Inc.Cell populations which co-express CD49c and CD90US20050239897Mar 15, 2005Oct 27, 2005Pittenger Mark FMesenchymal stem cells and uses thereforUS20050266391Jan 14, 2005Dec 1, 2005Bennett Brydon LMethods for preserving tissueUS20050272148Jul 21, 2005Dec 8, 2005Hariri Robert JMethod of collecting placental stem cellsUS20050276792Mar 22, 2005Dec 15, 2005Kaminski Joseph KSystems and methods for providing a stem cell bankUS20050282272Sep 24, 2004Dec 22, 2005The Robarts Research InstituteUsing undifferentiated embryonic stem cells to control the immune systemUS20050283844Mar 21, 2005Dec 22, 2005Furcht Leo TMultipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereofUS20060008450Jun 13, 2005Jan 12, 2006Verfaillie Catherine MUse of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failureUS20060078993Aug 15, 2005Apr 13, 2006Cellresearch Corporation Pte LtdIsolation, cultivation and uses of stem/progenitor cellsUS20060153816Dec 22, 2005Jul 13, 2006Laura BrownSoft tissue repair and regeneration using postpartum-derived cells and cell productsUS20060153817Dec 29, 2005Jul 13, 2006Ethicon, IncorporatedCartilage and bone repair and regeneration using postpartum-derived cellsUS20060153818Dec 29, 2005Jul 13, 2006Ethicon, IncorporatedCartilage and bone repair and regeneration using postpartum-derived cellsUS20060154366Dec 22, 2005Jul 13, 2006Laura BrownTreatment of osteochondral diseases using postpartum-derived cells and products thereofUS20060154367Dec 29, 2005Jul 13, 2006Ethicon, IncorporatedCartilage and bone repair and regeneration using postpartum-derived cellsUS20060166361Dec 8, 2005Jul 27, 2006Agnieszka SeydaPostpartum cells derived from placental tissue, and methods of making, culturing, and using the sameUS20060171930Dec 8, 2005Aug 3, 2006Agnieszka SeydaPostpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the sameUS20060188983Dec 30, 2005Aug 24, 2006Ethicon IncorporatedPostpartum-derived cells for use in treatment of disease of the heart and circulatory systemUS20060222634Mar 29, 2006Oct 5, 2006Clarke Diana LAmnion-derived cell compositions, methods of making and uses thereofUS20060233765Dec 22, 2005Oct 19, 2006Ethicon, IncorporatedTreatment of stroke and other acute neuraldegenerative disorders using postpartum derived cellsUS20060233766Dec 22, 2005Oct 19, 2006Messina Darin JTreatment of Parkinson's disease and related disorders using postpartum derived cellsUS20060234376Dec 23, 2005Oct 19, 2006Ethicon IncorporatedRepair and regeneration of ocular tissue using postpartum-derived cellsUS20060263337Nov 9, 2005Nov 23, 2006Richard MaziarzImmunomodulatory properties of multipotent adult progenitor cells and uses thereofUS20060281178Aug 25, 2006Dec 14, 2006Norio SakuragawaHuman stem cells originating from human amniotic mesenchymal cell layerUS20070041954Jul 13, 2006Feb 22, 2007Ichim Thomas ECompositions of placentally-derived stem cells for the treatment of cancerUS20070053888Nov 6, 2006Mar 8, 2007Hariri Robert JUse of umbilical cord blood to treat individuals having a disease, disorder or conditionUS20070092497Nov 3, 2006Apr 26, 2007Hariri Robert JCytotherapeutics, cytotherapeutic units and methods for treatments using themUS20070134210Oct 13, 2006Jun 14, 2007Mohammad HeidaranProduction of oligodendrocytes from placenta-derived stem cellsUS20070190034Oct 13, 2006Aug 16, 2007Casper PaludanImmunomodulation using placental stem cellsUS20070190042Dec 28, 2006Aug 16, 2007Edinger James WComposition for collecting and preserving placental stem cells and methods of using the compositionUS20070275362Dec 28, 2006Nov 29, 2007James EdingerPlacental stem cell populationsUS20070292399Dec 28, 2006Dec 20, 2007Mohammad HeidaranCo-culture of placental stem cells and stem cells from a second sourceUS20070292910Dec 28, 2006Dec 20, 2007Mohammad HeidaranCo-culture of placental stem cells and stem cells from a second sourceUS20080032401Dec 28, 2006Feb 7, 2008James EdingerPlacental stem cell populationsUS20080131410Oct 31, 2007Jun 5, 2008Hariri Robert JPlacental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cellsUS20080131966Oct 29, 2007Jun 5, 2008Hariri Robert JRenovation and repopulation of decellularized tissues and cadaveric organs by stem cellsUS20080152624Aug 3, 2007Jun 26, 2008Casper PaludanTumor suppression using placental stem cellsUS20090126482Oct 8, 2008May 21, 2009Avair, LlcBreathing gas supply visual broadcast apparatusUS20090226406Mar 2, 2009Sep 10, 2009Hariri Robert JModulation of stem and progenitor cell differentiation, assays, and uses thereofUS20090252710Sep 29, 2008Oct 8, 2009Celgene Cellular TherapeuticsTumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cellsUS20100047213Feb 25, 2010Andy ZeitlinCell composition and methods of making the sameUS20100047214Feb 25, 2010Abramson Sascha DMethods and Compositions for Treatment of Bone Defects with Placental Cell PopulationsUS20100047351Aug 20, 2009Feb 25, 2010Andy ZeitlinTreatment of stroke using isolated placental cellsUS20100120015Nov 13, 2009May 13, 2010Hariri Robert JMethod of collecting placental stem cellsUS20100124569Nov 19, 2009May 20, 2010Abbot StewartAmnion derived adherent cellsUS20100143312Nov 23, 2009Jun 10, 2010Hariri Robert JTreatment of diseases, disorders or conditions of the lung using placental cellsUS20100183571Jan 14, 2010Jul 22, 2010Anthrogenesis CorporationTreatment of multiple sclerosis using placental stem cellsUS20100260847Oct 14, 2010Anthrogenesis CorporationTissue matrices comprising placental stem cellsUS20100291679Jul 29, 2010Nov 18, 2010Anthrogenesis CorporationComposition for collecting and preserving placental stem cells and methods of using the compositionUS20100297689Jul 30, 2010Nov 25, 2010Anthrogenesis CorporationPlacental stem cell populationsUS20100323446Jun 3, 2010Dec 23, 2010Jill Renee BarnettMethod of collecting placental cellsUS20110003387Jul 1, 2010Jan 6, 2011Abbot StewartMethod of producing erythrocytes without feeder cellsCN1548529AMay 9, 2003Nov 24, 2004中国人民解放军军事医学科学院基础医Separation method of buffering stem cell in human placentaEP0333328B1Feb 17, 1989Dec 8, 1993Genethics LimitedClinical developments using amniotic cellsJP2003235549A Title not availableJP2005151907A Title not availableWO1990011354A1Mar 19, 1990Oct 4, 1990Pasteur InstitutProcess for the specific replacement of a copy of a gene present in the receiver genome via the integration of a geneWO1991001140A1Jul 25, 1990Feb 7, 1991Cell Genesys IncHomologous recombination for universal donor cells and chimeric mammalian hostsWO1991006667A1Nov 6, 1990May 16, 1991Cell Genesys IncProduction of proteins using homologous recombinationWO1993004169A1Aug 20, 1992Mar 4, 1993Genpharm IntGene targeting in animal cells using isogenic dna constructsWO1995022611A2Feb 21, 1995Aug 24, 1995Univ MichiganMethods and compositions for stimulating bone cellsWO1995022611A3Feb 21, 1995Feb 8, 1996Univ MichiganMethods and compositions for stimulating bone cellsWO1996039101A1Jun 6, 1996Dec 12, 1996Advanced Tissue Sciences IncCompositions and methods for naturally secreted extracellular matrixWO1998037903A1Feb 25, 1998Sep 3, 1998Scheffer C G TsengGrafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeriesWO1999064566A2Jun 8, 1999Dec 16, 1999Osiris Therapeutics IncIn vitro maintenance of hematopoietic stem cellsWO2000017325A1Sep 23, 1999Mar 30, 2000Mount Sinai Hospital CorpTrophoblast cell preparationsWO2000027999A2Nov 12, 1999May 18, 2000Cytomatrix LlcLymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devicesWO2000027999A3Nov 12, 1999Aug 3, 2000Cytomatrix LlcLymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devicesWO2000073421A2Jun 1, 2000Dec 7, 2000Lifebank Services L L CMethods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cellsWO2000073421A3Jun 1, 2000Apr 26, 2001Lifebank Services L L CMethods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cellsWO2001093909A2Jun 4, 2001Dec 13, 2001Stephen Thomas DavisCancer treatment composition containing an anti-neoplastic agent and a pde4 inhibitorWO2001093909A3Jun 4, 2001Dec 5, 2002Stephen Thomas DavisCancer treatment composition containing an anti-neoplastic agent and a pde4 inhibitorWO2002046373A1Dec 5, 2001Jun 13, 2002Robert J HaririMethod of collecting placental stem cellsWO2002063962A Title not availableWO2005105992A1Apr 19, 2005Nov 10, 2005Dan-Ning HuChondrocyte culture formulations* Cited by examinerNon-Patent CitationsReference1Abbott, 2003, ABCG2 (BCRP)expression in normal and malignant hematopoietic cells, Hematol Oncol 21:115-130.2Abe, "Therapeutic Potential of Neurotrophic Factors and Neural Stem Cells Against lschemic Brain Injury," Journal of Cerebral Blood Flow and Metabolism, Raven Press, Ltd., New York, 20(10): 1393-1408 (2000).3Abkowitz, 2002, Can human hematopoietic stem cells become skin, gut, or liver cells? N Engl J Med. 346(10):770-2.4Addison et al., "Metabolism of Prednisolone by the Isolated Perfused Human Placental Lobule", J. Ster. Biochem Mol. Biol., vol. 39 No. 1, pp. 83-90 (1991).5Advisory Action dated Aug. 17, 2009 in U.S. Appl. No. 10/721,444.6Advisory Action dated Feb. 6, 2006 in U.S. Appl. No. 10/721,144.7Advisory Action dated Jul. 12, 2004 in U.S. Appl. No. 10/076,180.8Advisory Action dated Jun. 6, 2006 in U.S. Appl. No. 10/779,369.9Advisory Action dated Oct. 7, 2009 in U.S. Appl. No. 10/721,144.10Ballin, et al., "Autologous Umbilical Cord Blood Transfusion," Arch. Dis. Child Fetal Neonatal. Ed. 73(3):F181-F183 (1995).11 *Barlow et al. Stem Cell Dev 2008;17:1095-1108.12Barry, 1994, "Where do all the placentas go?" Canadian Journal of Infection Control 9(1):8-10.13Belvedere et al., 2000, "Increased blood volume and CD34(+)CD36(-) progenitor cell recovery using a novel umbilical cord blood collection system," Stem Cells 18(4):245-251.14Belvedere et al., 2000, "Increased blood volume and CD34(+)CD36(−) progenitor cell recovery using a novel umbilical cord blood collection system," Stem Cells 18(4):245-251.15Bertolini et al., 1994, Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells. Haemolotol 88:318-324.16Caplan, Clin Plast Surg 21(3):429-435 (1994).17CD34, Medline Mesh Database, 2004.18Chen et al. "Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats" Stroke 32:2682-2688 (2001).19Cole et al., 1985, EBV-Hydrudoma techique and its application to human lung cancer. In Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., 77-96.20Conget et al. "Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells" Journal of Cellular Physiology 181:67-73 (1999).21Contractor et al., 1984, "A comparison of the effects of different perfusion regimens on the structure of the isolated human placental lobule," Cell Tissue Res. 237:609-617.22Cord Blood Stem Cell, Mesh Term Database, 2003.23Cote et al., 1983, Generation of human monoclonal antibodies reactive with cellular antigens. Proc Natl Acad Sci U S A. 80(7):2026-30.24Damjanov et al., 1993, Retinoic acid-induced differentiation of the developmentally plutipotent human germ cell tumor-derived cell line, NCCIT. Lab Invest. 68(2):220-32.25 *Deans et al. Exp Hematol 2000;28: 875-84.26DeLoia et al, 1998, Effects of methotrexate on trophoblast proliferation and local immune responses.Hum Reprod. 13(4):1063-9.27Denison et al. "Cytokine secretion by human fetal membranes, decidua and placenta at term" Human Reproduction 13(12):3560-3565 (1998).28Dorrel, 2000, Expansion of human cord blood CD34+CD38- cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulation cell (SRC) frequency: dissociation of SRC phenotype and function, Blood, 95(1):102-110.29Dorrel, 2000, Expansion of human cord blood CD34+CD38− cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulation cell (SRC) frequency: dissociation of SRC phenotype and function, Blood, 95(1):102-110.30Douay et al, 1995. Characterization of late and early hematopoietic progenitor/stem cell sensitivity to mafosfamide. Bone Marrow Transplant. 15(5):769-75.31Dushnik-Levinson et al. 1995, Embryogenesis in vitro: study of differentiation of embryonic stem cells.Biol Neonate. 67(2):77-83.32Elebalal et al., 2000, "Postpartum umbilical cord blood collection for transplantation: a comparison of three methods," Am. J. of Obstetrics & Gyn. 182(1 Pt 1):227-232.33Emerson, 1996, Ex vivo expansion of hematopoietic precursors, progenitors and stem cells: the next generation of cellular therapeutics, Blood, 87:3072-3088.34Ende, "Pooled umbilical cord blood as a possible universal donor for marrow reconstitution and use in nuclear accidents," Life Sciences 69:1531-1539 (2001).35Erices et al., "Mesenchymal progenitor cells in human umbilical cord blood," Br. J. Haematol. 109(1):235-242 (2000).36Extended European Search Report dated Mar. 11, 2011 for EP Application No. 10183435.6-2401 (specification corresponding to U.S. Patent No. 7,045,148).37Extended European Search Report dated Mar. 22, 2011 for EP Application No. 10183252.5-2401 (specification corresponding to U.S. Patent No. 7,311,904).38Extended European Search Report dated Mar. 25, 2011 for EP Application No. 10182195.7-2401 (specification corresponding to U.S. Patent No. 7,468,276).39Extended European Search Report dated Mar. 25, 2011 for EP Application No. 10182243.5-2401 (specification corresponding to U.S. Patent No. 7,468,276).40Extended European Search Report dated Mar. 25, 2011 for EP Application No. 10182362.3-2401 (specification corresponding to U.S. Patent No. 7,468,276).41Extended European Search Report dated Mar. 25, 2011 for EP Application No. 10182485.2-2401 (specification corresponding to U.S. Patent No. 7,468,276).42Extended European Search Report dated Mar. 25, 2011 for EP Application No. 10183301.0-2401 (specification corresponding to U.S. Patent No. 7,311,904).43Extended European Search Report dated Mar. 28, 2011 for EP Application No. 10182433.2-2401 (specification corresponding to U.S. Patent No. 7,468,276).44Extended European Search Report dated Mar. 3, 2011 for EP Application No. 10183378.8-2401 (specification corresponding to U.S. Patent No. 7,045,148).45Extended European Search Report dated Mar. 30, 2011 for EP Application No. 10182303.7-2401 (specification corresponding to U.S. Patent No. 7,468,276).46Extended Search Report mailed Mar. 25, 2011 in Application No. EP 10182243.5-2401.47Fasouliotis et al., "Human umbilical cord blood banking and transplantation: a state of the art," Eur. J. Obstet. Gynecol. Reprod. Biol. 90(1):13-25 (2000).48Fassas, et al., "Autologous Stem Cell Transplantation in Progressive Multiple Sclerosis—An Interim Analysis of Efficacy," J. Clin, Immunol., 20(1):24-30 (2000).49Final Office Action dated Aug. 4, 2010 in U.S. Appl. No. 11/592,544.50Final Office Action dated Feb. 1, 2011 in U.S. Appl. No. 11/982,291.51Final Office Action dated Feb. 7, 2011 in U.S. Appl. No. 12/030,161.52Final Office Action dated Jan. 28, 2011 in U.S. Appl. No. 11/982,007.53Final Office Action dated May 20, 2010 in U.S. Appl. No. 11/648,804.54Final Office Action dated Nov. 3, 2010 in U.S. Appl. No. 11/982,211.55Final Office Action dated Nov. 3, 2010 in U.S. Appl. No. 12/030,170.56Final Office Action dated Nov. 7, 2005 in U.S. Appl. No. 10/779,369.57Final Office Action dated Oct. 27, 2009 in U.S. Appl. No. 11/648,813.58Final Office Action dated Sep. 14, 2010 in U.S. Appl. No. 10/721,144.59Genbacev et al. 1995,Maternal smoking inhibits early human cytotrophoblast differentiation. Reprod Toxicol. 9(3):245-55.60Hatzopoulos et al. 1998, Isolation and characterization of endothelial progenitor cells from mouse embryos.Development. 125(8):1457-68.61Himori, et al , 1984, Chemotherapeutic susceptibility of human bone marrow progenitor cells and human myelogenous leukemia cells (HL-60) in co-culture: preliminary report. Int J Cell Cloning. 2(4):254-62.62Hirashima et al. 1999, Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. Blood. 93(4):1253-63.63Hsieh et al. "Effects of glucose on placental hormones in the human term placenta in vitro" J. Formos. Med. Assoc. 96:309-313 (1997).64Hume et al., "Red Blood Cell Transfusions For Preterm Infants: The Role of Evidence-Based Medicine," Seminars in Perinatology, W.B. Saunders, GB 21(1):14-15 (1997).65Jaroscak et al. "Preliminary characterization of the surface staining of placental derived adherent cells: a potential new source of stroma for umbilical cord blood (UCB) expansion," Blood 96(11, Pt 2) (2000).66Kawata et al., "Transcriptional Control of HLA-A,B,C Antigen in Human Placental Cytotrophoblast Isolated Using Trophoblast- and HLA-Specific Monoclonal Antibodies and the Fluorescence-Activated Cell Sorter," J. Exp. Med. 160(3):633-51 (1984).67Keown et al., 1990, Methods for introducing DNA into mammalian cells. Methods Enzymol. 185:527-37.68Korbling et al., 2002, Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 346(10):738-46.69Kozbor et al., 1983, The productrion of monoclonal antibodies from human lymphocytes. Immunology Today 4, 72-79.70Kurtzberg et al., 1996, Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 335:157-166.71Larsson et al., 2002, Angiogenesis. 5:107-110.72Leonard et al., 2003, Oncologist. 8:411-424.73Lowy et al. 1980, Isolation of transforming DNA: cloning the hamster aprt gene. Cell. 22(3):817-23.74Ma et al., 1999, Development of an in vitro human placenta model by the cultivation of human ytophoblasts in a fiber-based bioreactor system, tissue Engineering 5:91-102.75MacLaren et al., 1992, Inter- and Intraspecific Placentae in Sheep, Goats and Sheep-Goat Chimaeras, J Comp Pathol, 106:279-297.76Madri et al., 1983, Capillary endothelial cell cultures: phenotypic modulation by matrix components, J Cell Biol 97:153-165.77Malek et al. "Lack of transport of erythropoietin across the human placenta as studied by an in vitro perfusion system," European Journal of Physiology 427:157-161 (1994).78Marmont, "New Horizons in the Treatment of Autoimmune Diseases: Immunoablation and Stem Cell Transplantation," Ann. Rev. Medicine 51:115-134 (2000).79Melchner, et al., 1985, Human placental conditioned medium reverses apparent commitment to differentiation of human promyelocytic leukemia cells (HL60) Blood. 66(6):1469-72.80Minguell et al., Exp Biol Med 226:507-520 (2001).81Moore et al., 1997, "A simple perfusion technique for isolation of maternal intervillous blood mononuclear cells from human placentae," J. Immunol. Methods 209(1):93-104.82M�hlemann et al., 1995, Placenta. 16:367-373.83Mulligan and Berg, 1981 Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase Proc Natl Acad Sci U S A. 78(4):2072-6.84Myllynen, dissertation, University of Oulu, 2003.85Nadkami et al. 1984, Effect of retinoic acid on bone-marrow committed stem cells (CFU-c) from chronic myeloid leukemia patients. Tumori. 70(6):503-5.86Non Final Office Action dated Dec. 15, 2009 in U.S. Appl. No. 12/030,170.87Non Final Office Action dated Feb. 1, 2011 in U.S. Appl. No. 10/721,144.88Non Final Office Action dated Feb. 4, 2009 in U.S. Appl. No. 11/592,544.89Non Final Office Action dated Jul. 15, 2010 in U.S. Appl. No. 11/982,291.90Non Final Office Action dated Jul. 19, 2010 in U.S. Appl. No. 11/982,007.91Non Final Office Action dated Jul. 9, 2010 in U.S. Appl. No. 12/259,259.92Non Final Office Action dated Jun. 4, 2010 in U.S. Appl. No. 12/030,170.93Non Final Office Action dated Jun. 7, 2010 in U.S. Appl. No. 11/648,813.94Non Final Office Action dated Jun. 7, 2010 in U.S. Appl. No. 11/980,012.95Non Final Office Action dated May 24, 2010 in U.S. Appl. No. 11/982,211.96Non Final Office Action dated May 26, 2010 in U.S. Appl. No. 12/030,161.97Non-Final Office Action dated Oct. 21, 2009 in U.S. Appl. No. 11/648,804.98Notice of Allowance dated Aug. 12, 2009 in U.S. Appl. No. 11/187,400.99Notice of Allowance dated Jan. 10, 2011 in U.S. Appl. No. 11/648,813.100Notice of Allowance dated Nov. 29, 2010 in U.S. Appl. No. 11/980,012.101Notice of Allowance in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148, Sep. 15, 2005.102Notice of Allowance in U.S. Appl. No. 10/074,976, now US Patent No. 7,311,904, Aug. 15, 2007.103Notice of Allowance in U.S. Appl. No. 10/366,671, now US Patent No. 7,311,905, Sep. 10, 2007.104Notice of Allowance in U.S. Appl. No. 10/640,428, now US Patent No. 7,255,879, May 21, 2007.105Office Action dated Apr. 20, 2007 in U.S. Appl. No. 11/187,400.106Office Action dated Aug. 28, 2003 in U.S. Appl. No. 10/076,180.107Office Action dated Dec. 16, 2004 in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148.108Office Action dated Dec. 28, 2006 in U.S. Appl. No. 10/721,144.109Office Action dated Dec. 5, 2003 in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148.110Office Action dated Feb. 5, 2008 in U.S. Appl. No. 10/721,144.111Office Action dated Jan. 11, 2006 in U.S. Appl. No. 10/721,144.112Office Action dated Jan. 19, 2006 in U.S. Appl. No. 10/640,428, now US Patent No. 7,255,879.113Office Action dated Jan. 26, 2009 in U.S. Appl. No. 11/648,813.114Office Action dated Jan. 29, 2006 in U.S. Appl. No. 10/366,671, now US Patent No. 7,311,905.115Office Action dated Jan. 4, 2008 in U.S. Appl. No. 11/187,400.116Office Action dated Jan. 5, 2006 in U.S. Appl. No. 10/074,976, now US Patent No. 7,311,904.117Office Action dated Jun. 14, 2006 in U.S. Appl. No. 10/721,144.118Office Action dated Jun. 15, 2004 in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148.119Office Action dated Jun. 20, 2005 in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148.120Office Action dated Jun. 20, 2005 in U.S. Appl. No. 10/076,180.121Office Action dated Jun. 27, 2007 in U.S. Appl. No. 10/721,144.122Office Action dated Mar. 18, 2004 in U.S. Appl. No. 10/076,180.123Office Action dated Mar. 18, 2010 in U.S. Appl. No. 10/721,144.124Office Action dated Mar. 27 2007 in U.S. Appl. No. 10/074,976, now US Patent No. 7,311,904.125Office Action dated Mar. 29, 2005 in U.S. Appl. No. 10/779,369.126Office Action dated May 14, 2007 in U.S. Appl. No. 10/366,671, now US Patent No. 7,311,905.127Office Action dated May 22, 2008 in U.S. Appl. No. 11/187,400.128Office Action dated May 7, 2003 in U.S. Appl. No. 10/004,942, now US Patent No. 7,045,148.129Office Action dated Oct. 10, 2006 in U.S. Appl. No. 10/366,671, now US Patent No. 7,311,905.130Office Action dated Oct. 18, 2006 in U.S. Appl. No. 10/640,428, now US Patent No. 7,255,879.131Office Action dated Oct. 20, 2004 in U.S. Appl. No. 10/076,180.132Office Action dated Oct. 4, 2005 in U.S. Appl. No. 10/721,144.133Office Action dated Sep. 20, 2006 in U.S. Appl. No. 10/074,976, now US Patent No. 7,311,904.134Office Action dated Sep. 23, 2004 in U.S. Appl. No. 10/074,976, now US Patent No. 7,311,904.135O'Hare et al. 1981, Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A. 78(3):1527-31.136Oppenheim et al., 2001, Evidence against humoral immune attach as the cause of sheep-goat interspecies and hybrid pregnancy failure in the doe, Theriogenology 55:1567-1581.137Ordi et al., 1998, Am J Surg Pathol. 8:1006-1011.138Papaioannou et al., Stem Cells Handbook:19-31 (2004).139Parolini et al. "Concise review: Isolation and characterization of cells from human term placenta: Outcome of the first international workshop on placenta derived stem cells" Stem Cells 26:300-311 (2008).140Pittenger, M. F., et al. "Multilineage Potential of Adult Human Mesenchymal Stem Cells," Science (1999) U.S. vol. 284, No. 5411, pp. 143-147.141Placenta, Britannica Online, 2003.142Ponticiello et al. "Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy" Journal of Biomedical Materials Research 52:246-255 (2000).143Ray et al., 1997, CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. J Biol Chem. Jul. 25, 1997;272(30):18702-8.144Reubinoff, "Neural Progenitors from Human Embryonic Stem Cells," Nature Biotech. 19(12):1134-1140 (2001).145Reyes et al. 2002, Origin of endothelial progenitors in human postnatal bone marrow.J Clin Invest. 109(3):337-46.146Reyes et al., "Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells," Blood 98(9):2615-2625 (2001).147Santerre et al., 1984, Expression of prokaryotic genes for hygromycin B and G418 resistance as dominant-selection markers in mouse L cells. Gene. 30(1-3):147-56.148Semenov et al. "Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of sternness after isolation" American Journal of Obstetrics & Gynecolocy 202:193.e1-13 (2010).149Shamblott, et al., 1998, Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci U S A. 95(23):13726-31.150Slager 1993, Transforming growth factor-beta in the early mouse embryo: implications for the regulation of muscle formation and implantation. Dev Genet. 14(3):212-24.151Smithies et al. 1985, Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 317(6034):230-4.152Srour, 1999, Ex vivo expansion of hematopoietic stem and progenitor cells. Are we there yet? The Journal of Hematotherapy 8:93-102.153Stromberg et al., 1980, Methods in cell biology, Chapter 10: The human Placenta in cell and organ culture, 21:227-252.154Szybalska and Szybalska, 1962, Genetics of human cell lines IV: DNA-mediated heritable transformation of biochemical trait. PNAS 48: 2026-2034.155Thomas and Capecchi, 1987, Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell. 51(3):503-12.156Thomson et al., 1998, Embryonic stem cell lines derived from human blastocysts. Science. 282 (5391): 1145-7.157Totipotent Stem Cells, Medline, Mesh Database, 2004.158Totipotent Stem Cells, Stem Cells Information Center Online, 2004.159Tremblay et al., 2001, Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev. 15(7):833-8.160Turner et al., 1992, "A modified harvest technique for cord blood hematopoietic stem cells," Bone Marrow Transplantation 10:89-91.161U.S. Appl. No. 11/580,588, filed Oct. 13, 2006, Paludan.162U.S. Appl. No. 11/580,625, filed Oct. 13, 2006, Heidaran.163U.S. Appl. No. 11/648,802, filed Dec. 28, 2006, Heidaran.164U.S. Appl. No. 11/648,804, filed Dec. 28, 2006, Edinger.165U.S. Appl. No. 11/648,812, filed Dec. 28, 2006, Heidaran.166U.S. Appl. No. 11/648,813, filed Dec. 28, 2006, Edinger.167U.S. Appl. No. 11/648,824, filed Dec. 28, 2006, Heidaran.168U.S. Appl. No. 11/877,475, filed Oct. 23, 2007, Edinger et al.169U.S. Appl. No. 11/982,211, filed Oct. 31, 2007, Heidaran et al.170U.S. Appl. No. 11/982,291, filed Oct. 31, 2007, Edinger et al.171U.S. Appl. No. 12/030,161, filed Feb. 12, 2008, Edinger et al.172U.S. Appl. No. 12/030,170, filed Feb. 12, 2008, Edinger et al.173U.S. Appl. No. 12/823,063, filed Jun. 24, 2010, Hariri.174U.S. Appl. No. 12/829,326, filed Jul. 1, 2010, Abbot.175U.S. Appl. No. 12/846,765, filed Jul. 29, 2010, Edinger et al.176U.S. Appl. No. 12/848,007, filed Jul. 30, 2010, Edinger et al.177U.S. Appl. No. 13/081,415, filed Apr. 6, 2011, Abbot.178U.S. Appl. No. 13/081,422, filed Apr. 6, 2011, Edinger.179Uchimura et al. 1998, Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sislyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. J Biochem (Tokyo). 124(3):670-8.180Van Bekkum, Verh Disch Ges Patol 74:19-24 (1990).181Vawda et al., "Stem Cell Therapies for Perinatal Brain Injuries", Seminars in Fetal and Neonatal Medicine, Elsevier, GB 12(4):259-272 (2007).182Viscord, 2001, Umbilical cord blood can save lives (Informational brochure), Boston: ViaCell CENTR-BRO R1 Oct. 2001.183Wang et al., 2001, "Enhanced recovery of hematopoietic progenitor and stem cells from cultivated, postpartum human placenta," Blood 98(11/1):183a Abstract No. 769.184Wigler et al. 1997, Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. 11(1):223-32.185Woods et al., "Osomometric and permeability characteristics of human placental/umbilical cord blood CD34+ cells and their application to cryopreservation," J. Hematother. Stem Cell Res. 9(2):161-173 (2000).186Xu et al. "Feeder-free growth of undifferentiated human embryonic stem cells" Nature Biotechnology 19:971-974 (2001).187Yan et al., 2001, Retinoic acid promotes differentiation of trophoblast stem cells to a giant cell fate.Dev Biol. 235(2):422-32.188Ye et al., 2001, "Recovery of placental-derived adherent cells with mesenchymal stem cell characteristics," Blood 98(11/1):147b Abstract No. 4260.189Yen et al. "Isolation of multipotent cells from human term placenta" Stem Cells 23:3-9 (2005).190Yin et al "AC133, a novel marker for human hematopoietic stem and progenitor cells" Blood 90(12):5002-5012 (1997).191Zhao, et al., "Human Bone Marrow Stem Cells Exhibit Neural Phenotypes After Transplantation and Ameliorate Neurological Deficits with Ischemic Brain Injury in Rats," Abstract of the Annual Meeting of the Society for Neuroscience, Society of Neuroscience, Washington, DC, 26(Jan. 2002):860.01, XP001159670 (2000).192Zhao, et al., "Transplanted Human Bone Marrow-Derived Adult Stem Cells Survive and Improve Functional Outcome in a Rat Model of Cortical Ischemic Brain Injury," Experimental , Neurology, Academic Press, New York, 164(2):465-466, XP001159669 (2000).* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS8057789Nov 15, 2011Anthrogenesis CorporationPlacental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cellsUS8071376Oct 13, 2006Dec 6, 2011Anthrogenesis CorporationProduction of oligodendrocytes from placenta-derived stem cellsUS8202703Jul 30, 2010Jun 19, 2012Anthrogenesis CorporationPlacental stem cell populationsUS8216566Jul 10, 2012Anthrogenesis CorporationTreatment of multiple sclerosis using placental stem cellsUS8293223Oct 23, 2012Anthrogenesis CorporationTreatment of organ injuries and burns using placental stem cellsUS8372437Aug 17, 2007Feb 12, 2013Mimedx Group, Inc.Placental tissue graftsUS8435788Jun 24, 2010May 7, 2013Anthrogenesis CorporationTissue matrices comprising placental stem cellsUS8460715Aug 7, 2012Jun 11, 2013Mimedx Group, Inc.Placental tissue graftsUS8460716Aug 7, 2012Jun 11, 2013Mimedx Group, Inc.Method for applying a label to a placental tissue graftUS8562973Apr 6, 2011Oct 22, 2013Anthrogenesis CorporationTreatment of sarcoidosis using placental stem cellsUS8574567Sep 24, 2010Nov 5, 2013The Brigham And Women's Hospital, Inc.Multipotent stem cells and uses thereofUS8580563Oct 27, 2008Nov 12, 2013Anthrogenesis CorporationPlacental stem cellsUS8586360Jul 1, 2010Nov 19, 2013Anthrogenesis CorporationMethod of producing erythrocytes without feeder cellsUS8591883May 16, 2012Nov 26, 2013Anthrogenesis CorporationPlacental stem cell populationsUS8597687Aug 7, 2012Dec 3, 2013Mimedx Group, Inc.Methods for determining the orientation of a tissue graftUS8623421Jul 26, 2013Jan 7, 2014Mimedx Group, Inc.Placental graftUS8691217May 24, 2012Apr 8, 2014Anthrogenesis CorporationPlacental stem cell populationsUS8709494Jul 30, 2013Apr 29, 2014Mimedx Group, Inc.Placental tissue graftsUS8796315Mar 15, 2013Aug 5, 2014Darlene E. 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