Source: http://www.google.ca/patents/US7693259
Timestamp: 2015-09-05 07:45:16
Document Index: 732656784

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60']

Patent US7693259 - Orthovoltage radiotherapy - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based...http://www.google.ca/patents/US7693259?utm_source=gb-gplus-sharePatent US7693259 - Orthovoltage radiotherapyAdvanced Patent SearchPublication numberUS7693259 B2Publication typeGrantApplication numberUS 12/024,934Publication date6 Apr 2010Filing date1 Feb 2008Priority date16 Oct 2006Fee statusPaidAlso published asCA2666366A1, CN101588842A, CN101588842B, CN103446676A, EP2077901A2, EP2077901A4, US7496174, US7535991, US7564946, US7680244, US7680245, US7693258, US7697663, US7822175, US7912178, US8059784, US8073105, US8094779, US8180021, US8189739, US8320524, US8611497, US8761336, US8837675, US8995618, US20080089480, US20080089481, US20080144771, US20080181362, US20080187098, US20080187099, US20080187100, US20080187101, US20080187102, US20080192893, US20100172473, US20100195794, US20100254513, US20100260320, US20110038456, US20110170665, US20120057675, US20120076272, US20120177179, US20140105362, WO2008118198A2, WO2008118198A3Publication number024934, 12024934, US 7693259 B2, US 7693259B2, US-B2-7693259, US7693259 B2, US7693259B2InventorsMichael GertnerOriginal AssigneeOraya Therapeutics, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (201), Non-Patent Citations (25), Referenced by (3), Classifications (9), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetOrthovoltage radiotherapy
US 7693259 B2Abstract
1. A method, for treating diseased tissue with radiation, comprising:
selecting a target disease from among a plurality of diseases, each of the plurality of diseases having an associated therapeutic dose of radiation;
determining, based on the target disease, a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system, the x-ray radiation beam delivering substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient afflicted by the target disease;
wherein each of the plurality of diseases requires a different maximal energy to achieve its associated therapeutic dose of radiation than the maximal energy required to achieve the associated therapeutic dose of radiation for another of the plurality of diseases; and
wherein the maximal energy in the x-ray radiation beam is based on the selected target disease and beam energy attenuation due to any tissue overlying the target tissue; and
outputting to an output module an indication of the determined maximal energy.
2. The method of claim 1, wherein the therapeutic dose of radiation associated with the target disease comprises a plurality of fractionated doses.
3. The method of claim 1, wherein the target disease affects an eye of the patient and the radiation beam is emitted toward the eye.
4. The method of claim 3, wherein the plurality of diseases comprises at least one of macular degeneration, a pterygium, an ocular tumor, diabetic retinopathy, glaucoma, and a premalignant lesion.
5. The method of claim 1, further comprising emitting x-ray radiation, based on the determined energy level, toward the target tissue to deliver a dose of radiation to the tissue.
6. The method of claim 5, further comprising collimating the radiation to a radiation beam having cross-sectional dimension of less than about 6 mm.
7. The method of claim 5, wherein the emitting comprises emitting a plurality of radiation beams toward the target tissue to deliver a dose of radiation to the tissue.
8. The method of claim 5, wherein the emitting comprises emitting x-ray radiation toward the target tissue to deliver a dose of radiation to the tissue.
9. The method of claim 8, wherein the emitting x-ray radiation comprises emitting a plurality of x-ray beams toward the tissue.
10. A system, for treating diseased tissue with radiation, comprising:
a processing module that receives an input, the input comprising a selection of a target disease from among a plurality of diseases, each of the plurality of diseases having an associated therapeutic dose of radiation, the processing module further determining, based on the target disease, a maximal energy in an x-ray radiation beam to be emitted from a radiotherapy system, the x-ray radiation beam delivering substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient afflicted by the target disease;
an output module, coupled to the processing module, that outputs, based on the input, an indication of the determined maximal energy.
11. The system of claim 10, further comprising the radiotherapy system, wherein the radiotherapy system is coupled to the output module and is configured to generate the radiation beam based on the indication of the determined maximal energy.
12. The system of claim 11, wherein the radiotherapy system comprises a power supply adapted to deliver between about 10 mA and about 800 mA of current to an anode of an x-ray tube that generates x-ray radiation.
13. The system of claim 12, wherein said anode is one of a stationary anode and a rotating anode.
14. The system of claim 12, wherein the radiotherapy system further comprises a collimator that collimates the x-ray radiation to an x-ray beam having a cross-sectional dimension of less than about 6 mm.
15. A method, for treating diseased tissue with radiation, comprising:
determining, based on the target disease, a maximal energy in a radiation beam to be emitted from a radiotherapy system, the radiation beam delivering substantially the therapeutic dose of radiation associated with the target disease to target tissue in a patient afflicted by the target disease; and
outputting to an output module an indication of the determined maximal energy;
inputting a maximum voltage to an x-ray tube of the radiotherapy system to a value of between about 30 kV and about 300 kV, based on the determined maximal energy;
wherein each of the plurality of diseases requires a different maximal energy and/or surface-to-depth ratio to achieve the associated therapeutic dose of radiation for that disease than is required to achieve the associated therapeutic dose of radiation for another of the plurality of diseases.
16. The method of claim 15, further comprising communicating the indication of the determined maximal energy from the output module to the radiotherapy system.
17. The method of claim 16, further comprising emitting the radiation beam, based on the indication of the determined maximal energy, from the radiotherapy system toward the target tissue.
18. The method of claim 17, further comprising collimating the x-ray beam with a collimator, such that the x-ray beam has a cross-sectional dimension of less than about 6 mm.
19. The method of claim 17, wherein the emitting comprises emitting a plurality of x-ray beams toward the target tissue to deliver fractionated doses of radiation to the tissue.
20. The method of claim 15, wherein the plurality of diseases comprises at least one of macular degeneration, a pterygium, an ocular tumor, diabetic retinopathy, glaucoma, and a premalignant lesion.
21. A method, of radiation therapy of an eye, comprising:
for an ocular disease having an associated dose of radiation useful to treat that disease, providing a distance to a target of eye tissue afflicted by the disease from a radiation source, located outside the eye, that emits an x-ray radiations beam to deliver the dose of radiation to the target; and
based on the distance of the target from the radiation source, outputting to an output module a maximal energy, of from about 50 keV to about 500 keV, required to achieve the dose of radiation in the x-ray radiation beam emitted from the radiation source to the target.
22. The method of claim 21, further comprising communicating the maximal energy from the output module to the radiation source.
23. The method of claim 21, further comprising emitting the radiation beam, from the radiation source, toward the target based on the maximal energy.
24. The method of claim 23, further comprising collimating the x-ray beam with a collimator, such that the x-ray beam has a cross-sectional dimension of less than about 6 mm.
25. The method of claim 24, further comprising applying energy to the eye from a source different than the radiation source in combination with the x-ray beam.
26. The method of claim 23, wherein the emitting comprises emitting a plurality of x-ray beams toward the tissue to deliver fractionated doses of radiation to the target.
27. The method of claim 23, further comprising applying a therapeutic agent to the eye in combination with the emitting the radiation beam.
28. The method of claim 23, wherein the applying comprises injecting the therapeutic agent into the eye in combination with the emitting the radiation beam.
29. The method of claim 21, wherein the ocular disease comprises at least one of macular degeneration, a pterygium, an ocular tumor, diabetic retinopathy, glaucoma, and a premalignant lesion.
This application is a continuation application of U.S. application Ser. No. 11/873,386, filed Oct. 16, 2007, which application claims priority benefit of U.S. Provisional Application No. 60/933,220, filed Jun. 4, 2007; U.S. Provisional Application No. 60/922,741, filed Apr. 9, 2007; U.S. Provisional Application No. 60/869,872, filed Dec. 13, 2006; U.S. Provisional Application No. 60/862,210, filed Oct. 19, 2006; U.S. Provisional Application No. 60/862,044, filed Oct. 18, 2006; and U.S. Provisional Application No. 60/829,676, filed Oct. 16, 2006; the entirety of each of which is incorporated herein by reference.
Another disease of the eye that is treatable with the systems, methods, and apparatus disclosed herein is pterygia of the eye. A pterygium is an elevated, superficial, external ocular mass that usually forms over the perilimbal conjunctiva and extends onto the corneal surface. Pterygia can vary from small, atrophic quiescent lesions to large, aggressive, rapidly growing fibrovascular lesions that can distort the corneal topography, and in advanced cases, can obscure the optical center of the cornea. The exact cause of pterygia is not well understood, although it occurs more often in people who spend a great deal of time outdoors, especially in sunny climates, and has been linked to long-term exposure to sunlight, especially ultraviolet rays, and chronic eye irritation from dry, dusty, and windy conditions. Pterygia can become inflamed, and the symptoms are often treated with topical eyedrops or ointments that can help to reduce the inflammation. If the pterygium is large enough to threaten sight, or encroaches on the cornea, the lesion is typically treated by surgical removal before vision is affected. However, even with most surgical techniques, the recurrence rate is often as high as 50 to 60 percent. The systems, methods, and apparatus disclosed herein can be used postoperatively to reduce the likelihood of recurrence of a pterygium by administration of radiation doses, and in some embodiments, doses of radiation can be used to slow or stop progression of the pterygium prior to surgery. (See, e.g., “Long-term results of non-surgical, exclusive strontium/yttrium-90 beta irradiation of pterygia,” Radiation and Oncology 74 (2005) 25-29; the entirety of which is incorporated herein by reference).
In some embodiments described herein, treatment systems are provided for delivering radiation to a patient that include an eye model derived from anatomic data of a patient's eye, an emitter that emits a radiation beam, and a position gui