Source: http://www.docstoc.com/docs/57339501/Imaging-Techniques-For-Reducing-Blind-Spots---Patent-7601966
Timestamp: 2013-12-18 19:00:46
Document Index: 205092509

Matched Legal Cases: ['Application No. 03810570', 'Application No. 0', 'Application No. 02716285', 'Application No. 03810570', 'Application No. 03810570', 'Application No. 10', 'Application No. 158442', 'Application No. 154323', 'Application No. 03810570', 'Application No. 01951883', 'Application No. 154323', 'Application No. 157007', 'Application No. 154323', 'Application No. 1817689', 'Application No. 0', 'Application No. 01817689']

Imaging Techniques For Reducing Blind Spots - Patent 7601966
United States Patent: 7601966
7,601,966
An imaging system is provided for radioimaging a region of interest (ROI)
of a subject. The system includes a housing, a support structure, which
is movably coupled to the housing, and at least one motor assembly,
coupled to the housing and the support structure, and configured to move
the support structure with respect to the housing. The system also
includes at least two detector assemblies, fixed to the support
structure, and comprising respective radiation detectors and angular
orientators. A control unit drives the motor assembly to position the
support structure in a plurality of positions with respect to the
housing, and, while the support structure is positioned in each of the
plurality of positions, drives the orientators to orient the respective
detectors in a plurality of rotational orientations with respect to the
ROI, and to detect radiation from the ROI at the rotational orientations.
Ben-Haim; Shlomo (London, GB), Melman; Haim (Kfar-Saba, IL), Nagler; Michael (Tel-Aviv, IL), Rousso; Benny (Rishon-LeZion, IL), Zilberstien; Yoel (Haifa, IL), Haj-Yahya; Sajed (Taybe, IL)
11/769,826
60816970Jun., 2006
G01T 1/00&amp;nbsp(20060101)
250/394,363.05,370.01-370.15 378/98.8,189
3739279
4773430
4844067
5088492
5249124
Engleston et al.
5880475
Raylman et al.
Freisenhahn
6229145
6346706
6353227
6368331
Front et al.
Berlad et al.
Daghighian et al.
6602488
Jimbo et al.
Engelston et al.
6713766
6728583
6731989
6740882
6767319
6813868
7490085
2002/0099334
2002/0103431
Toker et al.
2002/0168317
Daighighian et al.
2002/0183645
2002/0198738
2003/0001098
2003/0055685
2003/0081716
2003/0183226
2003/0202629
2004/0003001
2004/0015075
Kimchy et al.
2004/0051368
2004/0054248
2004/0054278
2004/0084340
2004/0086437
2004/0101176
Mendonca et al.
2004/0153128
2004/0156081
2004/0193453
2004/0204646
2004/0251419
2005/0020915
Bellardinelli et al.
2005/0029277
2005/0088306
2005/0107698
2005/0107914
2005/0108044
2005/0113945
2005/0121505
2005/0131270
2005/0131397
2005/0131579
2005/0145797
Oaknin et al.
2005/0148869
2005/0149350
2005/0171815
2005/0203389
2005/0205792
Besing et al.
2005/0240441
2005/0247893
2005/0261937
2005/0261938
2005/0266074
2005/0277833
2005/0277911
2005/0278066
2006/0160157
2006/0237652
2007/0166277
2007/0194241
2008/0033291
2008/0230705
2008/0237482
2008/0260228
Dichterman et al.
2008/0277591
19815362
0543262
0697193
6-109848
WO 92/00402
WO 98/16852
WO 99/30610
WO 99/39650
WO 00/22975
WO 01/89384
WO 2004/004787
WO 2004/032151
WO 2004/042546
WO 2005/002971
WO 2005/059840
WO 2005/118659
WO 2005/119025
WO 2006/042077
WO 2006/051531
WO 2006/054296
WO 2006/129301
WO 2007/010534
WO 2007/010537
WO 2007/054935
WO 2007/074467
WO 2008/010227
US. Appl. No. 60/625,971. cited by other
U.S. Appl. No. 60/628,105. cited by other
U.S. Appl. No. 60/630,561. cited by other
U.S. Appl. No. 60/632,236. cited by other
U.S. Appl. No. 60/632,515. cited by other
U.S. Appl. No. 60/635,630. cited by other
Van Den Bossche B et al., &quot;Receptor Imaging in Oncology by Means of Nuclear Medicine: Current Status&quot;, Journal of Clinical Oncology 22(17); 3593-3607, 2004 (an abstract). cited by other
Yao D et al., &quot;The utility of monoclonal antibodies in the imaging of prostate cancer&quot;, Semin Urol Oncol 20(3):211-8, 2002 (an abstract). cited by other
U.S. Appl. No. 60/636,088. cited by other
U.S. Appl. No. 60/640,215. cited by other
Van der Laken CJ et al., &quot;Technetium-99m-labeled chemotactic peptides in acute infection and sterile inflammation&quot;J Nucl Med 38(8):1310-5, 1997 (an abstract). cited by other
Babich JW et al., &quot;Localization of radiolabeled chemotactic peptide as focal sites of Escherichia coli infection in rabbits: evidence for a receptor-specific mechanism&quot;, J Nucl Med 38(8):1316-22 (an abstract). cited by other
U.S. Appl. No. 60/648,385. cited by other
U.S. Appl. No. 60/648,690. cited by other
Rao PS et al., &quot;99mTc-peptide-peptide nucleic acid probes for imaging oncogene mRNAs in tumours&quot;, Nuclear Medicine Communications 24(8):857-863, 2003 (an abstract). cited by other
Fischman AJ et al., &quot;Infection imaging with technetium-99m-labeled chemotactic peptide analogs&quot;, Semin Nucl Med 24(2) :154-68, 1994 (an abstract). cited by other
U.S. Appl. No. 60/675,892. cited by other
U.S. Appl. No. 60/691,780. cited by other
Massoud TF et al., &quot;Molecular imaging in living subjects: seeing fundamental biological processes in a new light&quot;, Genes &amp; development 17:545-580, 2003. cited by other
Gambhir SS, &quot;Molecular imaging of cancer with positron emission tomography&quot;, Nature Reviews 2:683-693, 2002. cited by other
U.S. Appl. No. 60/700,318. cited by other
U.S. Appl. No. 60/700,299. cited by other
&quot;Keeping Pace with Targeted Therapies in Lung Cancer&quot; Highlights from ASCO 2006 Annual Meeting. cited by other
U.S. Appl. No. 60/700,317. cited by other
U.S. Appl. No. 60/700,753. cited by other
U.S. Appl. No. 60/700,752. cited by other
U.S. Appl. No. 60/702,979. cited by other
U.S. Appl. No. 60/720,034. cited by other
U.S. Appl. No. 60/720,652. cited by other
U.S. Appl. No. 60/720,541. cited by other
U.S. Appl. No. 60/750,287. cited by other
U.S. Appl. No. 60/750,334. cited by other
U.S. Appl. No. 60/750,597. cited by other
U.S. Appl. No. 60/800,845. cited by other
U.S. Appl. No. 60/800,846. cited by other
U.S. Appl. No. 60/816,970. cited by other
PCT Patent Application No. PCT/IL2006/000562. cited by other
PCT Patent Application No. PCT/IL2005/001215. cited by other
PCT Patent Application No. PCT/IL2005/001173. cited by other
PCT Patent Application No. PCT/IL2005/000572. cited by other
PCT Patent Application No. PCT/IL2005/000575. cited by other
PCT Patent Application No. PCT/IL2006/000059. cited by other
PCT Patent Application No. PCT/IL2006/001511. cited by other
U.S. Appl. No. 11/034,007, filed Jan. 13, 2005. cited by other
U.S. Appl. No. 09/641,973, filed Aug. 21, 2000. cited by other
U.S. Appl. No. 11/607,075 filed Dec. 1, 2006. cited by other
U.S. Appl. No. 11/656,548 filed Jan. 13, 2005. cited by other
U.S. Appl. No. 10/533,568 filed Nov. 4, 2003. cited by other
U.S. Appl. No. 11/750,057 filed May 17, 2007. cited by other
Aoi et al. &quot;Absolute Quantitation of Regional Myocardial Blood Flow of Rats Using Dynamic Pinhole SPECT&quot;, IEEE Nuclear Science Symposium and Medical Imaging Conference Record, 3: 1780-1783, 2002. Abstract, Figs. cited by other
Hassan et al. &quot;A Radiotelemetry Pill for the Measurement of Ionising Radiation Using A Mercuric Iodide Detector&quot;, Physics in Medicine and Biology, 23(2): 302-308, 1978. cited by other
Hoffman et al. &quot;Intraoperative Probes and Imaging Probes&quot;, European Journal of Nuclear Medicine, 26(8): 913-935, 1999. cited by other
Zhang et al. &quot;An Innovative High Efficiency and High Resolution Probe for Prostate Imaging&quot;, The Journal of Nuclear Medicine, 68: 18, 2000. Abstract. cited by other
Official Action Dated Jan. 07, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,307. cited by other
Summons to Attend Oral Proceedings Pursuant to Rule 115(1) EPC Dated Jan. 16, 2009 From the European Patent Office Re.: Application No. 03810570.6. cited by other
Supplementary Partial European Search Report Dated Sep. 04, 2007 From the European Patent Office Re.: Application No. 0 2716285.8. cited by other
Supplementary Partial European Search Report Dated Nov. 20, 2007 From the European Patent Office Re.: Application No. 02716285.8. cited by other
Kinahan et al. &quot;Attenuation Correction for a Combined 3D Pet/Ct Scanner&quot;, Medical Physics, 25(10): 2046-2053, Oct. 1998. cited by other
Takahashi et al. &quot;Attenuation Correction of Myocardial Spect Images With X-Ray Ct: Effects of Registration Errors Between X-Ray Ct and Spect&quot;, Annals of Nuclear Medicine, 16(6): 431-435, Sep. 2002. cited by other
Yu et al. &quot;Using Correlated Ct Images in Compensation for Attenuation in Pet Image Reconstruction&quot;, Proceedings of the Spie, Applications of Optical Engineering: Proceedings of OE/Midwest &#39;90, 1396: 56-58, 1991. cited by other
Zaidi et al. &quot;Magenetic Resonance Imaging-Guided Attenuation and Scatter Corrections in Three-Dimensional Brain Positron Emission Tomography&quot;, Medical Physics, 30(5): 937-948, May 2003. cited by other
Zaidi et al. &quot;Mri-Guided Attenuation Correction in 3D Brain Pet&quot;, Neuroimage Human Brain Mapping 2002 Meeting, 16(2): Abstract 504, Jun. 2002. cited by other
International Search Report Sep. 12, 2002 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL02/00057. cited by other
Communication Pursuant to Article 96(2) Epc Dated Jun. 19, 2006 From the European Patent Office Re.: Application No. 03810570.6. cited by other
Communication pursuant to Article 96(2) Epc Dated Aug. 30, 2007 From the European Patent Office Re.: Application No. 03810570.6. cited by other
Communication Relating to the Results of the Partial International Search Dated Apr. 18, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/1L2006/001291. cited by other
Communication Relating to the Results of the Partial International Search Dated May 21, 2008 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2007/001588. cited by other
International Search Report Dated Jul. 11, 2008 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL06/01511. cited by other
International Search Report May 24, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00575. cited by other
International Search Report Dated Nov. 1, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL06/00840. cited by other
International Search Report Dated Jul. 25, 2008 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2007/001588. cited by other
International Search Report Dated Feb. 1, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00048. cited by other
International Search Report Dated Jul. 1, 2008, From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL06/00834. cited by other
International Search Report Dated Jul. 2, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2006/001291 . cited by other
International Search Report Dated Aug. 3, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/001173. cited by other
International Search Report Dated May 11, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/001215 . cited by other
International Search Report Dated Sep. 11, 2002 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL01/00638. cited by other
International Search Report Dated Mar. 18, 2004 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL03/00917. cited by other
International Search Report Dated Mar. 23, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00572. cited by other
International Search Report Dated 26 Mar. 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00394. cited by other
Official Action Dated Jun. 1, 2006 From the United States Patent and Trademark Office Re.: Application No. 10/686,536. cited by other
Official Action Dated Dec. 2, 2007 From the Israeli Patent Office Re.: Application No. 158442. cited by other
Official Action Dated May 3, 2007 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 10/240,239. cited by other
Official Action Dated Sep. 4, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/533,568. cited by other
Official Action Dated Sep. 5, 2002 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 12/084,559. cited by other
Official Action Dated Oct. 7, 2008 From the US Patent Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Aug. 10, 2007 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 10/836,223. cited by other
Official Action Dated Jul. 12, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Dec. 13, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Dec. 15, 2006 From the US Patent Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Apr.15, 2008 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 09/641,973. cited by other
Official Action Dated Feb. 15, 2008 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 10/343,792. cited by other
Official Action Dated Jul. 15, 2008 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 09/641,973. cited by other
Official Action Dated Mar. 15, 2004 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 09/725,316. cited by other
Official Action Dated Jan. 17, 2006 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 11/034,007. cited by other
Official Action Dated Jul. 17, 2007 From the Israeli Patent Office Re.: Application No. 154323. cited by other
Official Action Dated Apr. 20, 2006 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 10/240,239. cited by other
Official Action Dated Mar. 21, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/533,568. cited by other
Official Action Dated Jun. 23, 2006 From the United States Patent and Trademark Office Re.: U.S. Appl. No. 09/727,464. cited by other
Official Action Dated Jun. 25, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Sep. 25, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Sep. 30, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Supplementary European Search Report Dated Dec. 12, 2005 From the European Patent Office Re.: Application No. 03810570.6. cited by other
Supplementary Partial European Search Report Dated Nov. 11, 2008 From the European Patent Office Re.: Application No. 01951883.6. cited by other
Written Opinion Dated Feb. 1, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00048. cited by other
Written Opinion Dated Jul. 1, 2008 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL06/00834. cited by other
Written Opinion Dated Oct. 10, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL06/00059. cited by other
Written Opinion Dated Jul. 2, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL2006/001291. cited by other
Written Opinion Dated Mar. 23, 2006 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00572. cited by other
Written Opinion Dated May 24, 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/00575. cited by other
Written Opinion Dated Jul. 25, 2008 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05/001173. cited by other
Written Opinion Dated 26 Mar. 2007 From the International Searching Authority of the Patent Cooperation Treaty Re.: Application No. PCT/IL05100394. cited by other
Gugnin et al &quot;Radiocapsule for Recording the Ionizing Radiation in the Gastrointestinal Tract&quot;, UDC 615. 417:616.34-005.1-073.916-71 (All-Union Scientific-Research Institute of medical Instrument Design, Moscow. Translated from Meditsinskaya
Tekhnika, 1:21-25, Jan.-Feb. 1972). cited by other
Stoddart et al. &quot;New Multi-Dimensional Reconstructions for the 12-Detector, Scanned Focal Point, Single-Photon Tomograph&quot;, Physics in Medicine and Biology, XP020021960, 37(3): 579-586, Mar. 1, 1992. P.582, .sctn. 2 - P.585, .sctn. 1. cited by other
Official Action Dated May 13, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/798,017. cited by other
Official Action Dated May 14, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/656,548. cited by other
Official Action Dated Dec. 16, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/343,792. cited by other
Response Dated Mar. 13, 2008 to Official Action of Dec. 13, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Response Dated Mar. 15, 2007 to Official Action of Dec. 15, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Response Dated Sep. 22, 2008 to Official Action of Jun. 25, 2008 From US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Response Dated Oct. 31, 2007 to Official Action of Jul. 12, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Response Dated Apr. 7, 2009 to Official Action of Oct. 7, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Second International Search Report Dated Jun. 1, 2009 From the International Searching Authority Re.: Application No. PCT/IL07/00918. cited by other
Second Written Opinion Dated Jun. 1, 2009 From the International Searching Authority Re.: Application No. PCT/IL07/00918. cited by other
Bloch et al. &quot;Application of Computerized Tomography to Radiation Therapy and Surgical Planning&quot;, Proceedings of the IEEE, 71(3): 351-355, Mar. 1983. cited by other
Final OA dated Jul. 12, 2007. cited by other
Invitation To Pay Additional Fees. cited by other
Invitation to pay additional fees dated Apr. 18, 2007. cited by other
OA dated Sep. 4, 2008. cited by other
OA of Jun. 1, 2006. cited by other
OA of Aug. 10, 2007. cited by other
OA of Jan. 17, 2006. cited by other
OA of Jun. 19, 2006. cited by other
OA of Dec. 2, 2007. cited by other
OA of Jan. 7, 2009. cited by other
Official Action Dated May 3, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/240,239. cited by other
Official Action Dated Oct. 7, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Apr. 15, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 09/727,464. cited by other
Official Action Dated Dec. 15, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/616,301. cited by other
Official Action Dated Feb. 15, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/343,792. cited by other
Official Action Dated Apr. 20, 2006 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/240,239. cited by other
Official Action Dated Dec. 23, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 09/727,464. cited by other
Official Action Dated Jun. 23, 2006 From the US Patent and Trademark Office Re.:U.S. Appl. No. 09/727,464. cited by other
International Preliminary Report on Patentability Dated Apr. 16, 2009 From the International Bureau of WIPO Re.: Applicaiton No. PCT/IL2007/000918. cited by other
International Preliminary Report on Patentability Dated Jun. 21, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2005/000575. cited by other
International Preliminary Report on Patentability Dated Jan. 22, 2009 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/000834. cited by other
International Preliminary Report on Patentability Dated Jan. 22, 2009 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/001511. cited by other
International Preliminary Report on Patentability Dated May 22, 2007 From the International Preliminary Examining Authority Re.: Application No. PCT/IL06/00059. cited by other
International Preliminary Report on Patentability Dated May 22, 2008 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/001291. cited by other
International Preliminary Report on Patentability Dated May 24, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2005/001173. cited by other
International Preliminary Report on Patentability Dated Apr. 26, 2007 From the International Bureau of WIPO Re.: Application No. PCT/IL2005/000394. cited by other
International Preliminary Report on Patentability Dated Jan. 31, 2008 From the International Bureau of WIPO Re.: Application No. PCT/IL2006/000840. cited by other
International Search Report Dated Oct. 15, 2008 From the International Searching Authority Re.: Application No. PCT/IL07/00918. cited by other
Invitation to Pay Additional Fees Dated Jul. 10, 2008 From the International Searching Authority Re.: Application No. PCT/IL06101511. cited by other
Invitation to Pay Additional Fees Dated Feb. 15, 2007 From the International Searching Authority Re.: Application No. PCT/IL05/00575. cited by other
Office Action Dated Jan. 2, 2006 From the Israeli Patent Office Re.: Application No. 154323. cited by other
Office Action Dated Sep. 4, 2007 From the Israeli Patent Office Re.: Application No. 157007. cited by other
Office Action Dated Jul. 17, 2007 From the Israeli Patent Office Re.: Application No. 154323. cited by other
Official Action Dated Jan. 7, 2009 From the US Patent and Trademark Office Re.:U.S. Appl. No. 10/616,307. cited by other
Official Action Dated Nov. 26, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/240,239. cited by other
Official Action Dated Apr. 29, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/980,690. cited by other
Response Dated Aug. 14, 2008 to Official Action of Apr.15, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 09/727,464. cited by other
Response Dated Nov. 25, 2005 to Office Action of May 13, 2005 From the Patent Office of the People&#39;s Republic of China Re.: Application No. 1817689.5. cited by other
Response to the International Search Report and the Written Opinion of Oct. 10, 2006 From the International Searching Authority Re.: Appliction No. PCT/IL06/00059. cited by other
Supplementary Partial European Search Report Dated Sep. 4, 2007 From the European Patent Office Re.: Application No. 0 2716285.8. cited by other
Translation of Office Action Dated May 13, 2005 From the Patent Office of the People&#39;s Republic of China Re.: Application No. 01817689.5. cited by other
Written Opinion Dated Oct. 15, 2008 From the International Searching Authority Re.: Application No. PCT/IL07/00918. cited by other
Zaidi et al. &quot;Magenetic Resonance Imaging-Guided Attenuation and Scatter Corrections in ThreeDimensional Brain Positron Emission Tomography&quot;, Medical Physics, 30(5): 937-948, May 2003. cited by other
Hayakawa et al. &quot;A PET-MRI Registration Technique for PET Studies of the Rat Brain&quot;, Nuclear Medicine &amp; Biology, 27: 121-125, 2000. p. 121, Col.1. cited by other
Lavallee et al. &quot;Building A Hybrid Patient&#39;s Model for Augmented Reality in Surgery: A Registration Problem&quot;, Computing in Biological Medicine, 25(2): 149-164, 1995. p. 149-150. cited by other
Kojima et al. &quot;Quantitative Planar Imaging Method for Measurement of Renal Activity by Using A Conjugate-Emission Image and Transmission Data&quot;, Medical Physics, 27(3): 608-615, 2000. p. 608. cited by other
Pardridge et al. &quot;Tracer Kinetic Model of Blood-Brain Barrier Transport of Plasma Protein-Bound Ligands&quot;, Journal of Clinical Investigation, 74: 745-752, 1984. cited by other
Reutter et al. &quot;Direct Least Squares Estimation of Spatiotemporal Distributions From Dynamic SPECT Projections Using a Spatial Segmentation and Temporal B-Splines&quot;, IEEE Transactions on Medical Imaging, 19(5): 434-450, 2000. cited by other
Huesman et al. &quot;Kinetic Parameter Estimation From SPECT Cone-Beam Projection Measurements&quot;, Physics in Medicine and Biology, 43(4): 973-982, 1998. cited by other
Reutter et al. &quot;Kinetic Parameter Estimation From Attenuated SPECT Projection Measurements&quot;, IEEE Transactions on Nuclear Science, 45(6): 3007-3013, 1998. cited by other
Piperno et al. &quot;Breast Cancer Screening by Impedance Measurements&quot;, Frontiers Med. Biol. Engng., 2(2): 11-17, 1990. cited by other
Rajshelchar &quot;Continuous Impedence Monitoring During CT-Guided Stereotactic Surgery: Relative Value in Cystic and Solid Lesions&quot;, British Journal of Neurosurgery, 6: 439-444, 1992. cited by other
Jessup &quot;Tumor Markers - Prognostic and Therapeutic Implications for Colorectal Carcinoma&quot;, Surgical Oncology, 7: 139-151, 1998. cited by other
Corstens et al. &quot;Nuclear Medicine&#39;s Role in Infection and Inflamation&quot;, The Lancet, 354: 765-770, 1999. cited by other
Mori et al. &quot;Overexpression of Matrix Metalloproteinase-7mRNA in Human Colon Carcinomas&quot;, Cancer, 75: 1516-1519, 1995. cited by other
Erbil et al. &quot;Use and Limitations of Serum Total and Lipid-Bound Sialic Acid Concentrations as Markers for Colorectal Cancer&quot;, Cancer, 55: 404-409, 1985. cited by other
Molinolo et al. &quot;Enhanced Tumor Binding Using Immunohistochemical Analyses by Second Generation Anti-Tumor-Associated Glycoprotein 72 Monoclonal Antibodies versus Monoclonal Antibody B72.3 in Human Tissue&quot;, Cancer Research, 50: 1291-1298, 1990.
Day et al. &quot;Localization of Radioiodinated Rat Fibrogen in Transplanted Rat Tumors&quot;, J. Nat. Cancer Inst., 23: 799-812, 1959. cited by other.
Eckert Seamans Cherin &amp; Mellot, LLC
60/816,970, filed Jun. 28, 2006, entitle &quot;Imaging techniques for reducing
blind spots,&quot; which is assigned to the assignee of the present
1.  An imaging system for performing radiological imaging of a region of interest (ROI) of a subject, the system comprising: a housing;  a support structure, movably
coupled to the housing;  at least one motor assembly, coupled to the housing and the support structure, and configured to move the support structure with respect to the housing;  at least two detector assemblies, fixed to the support structure, and
comprising respective radiation detectors and angular orientators;  and a control unit, which is configured to perform a radiological imaging procedure by driving the motor assembly to position the support structure in a plurality of positions with
respect to the housing during a respective plurality of portions of the procedure, and while the support structure is positioned in each of the plurality of positions, driving the orientators to orient the respective detectors in a plurality of
rotational orientations with respect to the ROI, and to detect radiation from the ROI at least a portion of the rotational orientations.
2.  The system according to claim 1, wherein the housing and the support structure are configured such that, throughout the procedure, a furthest distance of all of the detectors from a center of the ROI throughout the procedure is less than
120% of a closest distance of all of the detectors from the center of the ROI.
3.  The system according to claim 1, wherein the at least two detector assemblies comprise at least five detector assemblies.
4.  The system according to claim 1, wherein the control unit is configured to drive the motor assembly to position the support structure such that at least one of the detectors moves at least 30 mm during the procedure.
5.  The system according to claim 1, wherein the system comprises exactly one motor assembly, which comprises exactly one motor.
6.  The system according to claim 1, wherein the plurality of rotational orientations includes at least 30 rotational orientations, and wherein the control unit is configured to drive the orientators to orient the respective detectors in the at
least 30 rotational orientations while the support structure is positioned in each of the plurality of positions.
7.  The system according to claim 1, wherein the plurality of positions includes exactly two positions, and wherein the control unit is configured to drive the motor to position the support structure in the two positions during two respective
portions of the procedure.
8.  The system according to claim 1, wherein the plurality of positions includes exactly three positions, and wherein the control unit is configured to drive the motor to position the support structure in the three positions during three
respective portions of the procedure.
9.  The system according to claim 1, wherein the support structure is generally L-shaped.
10.  The system according to claim 1, wherein the support structure is substantially rigid.
11.  The system according to claim 1, wherein the motor assembly comprises: a linear stepper motor;  a first pivoting post, which is coupled to the support structure;  and a second pivoting post, which is coupled to the housing.
12.  The system according to claim 1, wherein the motor assembly comprises a position encoder configured to generate a position signal, and wherein the control unit is configured to determine, responsively to the position signal, respective
positions of the detectors with respect to the ROI.
13.  The system according to claim 1, wherein none of the detector assemblies comprises a position sensor.
14.  The system according to claim 1, wherein the housing and support structure are configured such that, during the radiological imaging procedure, the support structure moves generally around an axis which is perpendicular to a plane defined
by the detectors and passes through the ROI.
15.  The system according to claim 1, wherein the system is configured to perform a SPECT radioimaging procedure.
16.  The system according to claim 1, wherein the radiation detectors are configured to detect photons.
17.  The system according to claim 1, wherein the support structure is configured to move with respect to the housing by sliding.
18.  A method for performing radiological imaging of a region of interest (ROI) of a subject, the method comprising performing a radiological imaging procedure by: driving at least one motor assembly to, during a plurality of portions of the
procedure, position a support structure in a respective plurality of positions with respect to a housing to which the support structure is movably coupled, which support structure is coupled to at least two radiation detectors;  and while the support
structure is positioned in each of the plurality of positions, driving orientators to orient the detectors in a plurality of rotational orientations with respect to the ROI, and, using the detectors, detecting radiation from the ROI at least a portion of
the rotational orientations.
19.  The method according to claim 18, wherein driving the at least one motor assembly to position the support structure comprises driving the at least one motor assembly to position the support structure such that, throughout the procedure, a
furthest distance of all of the detectors from a center of the ROI throughout the procedure is less than 120% of a closest distance of all of the detectors from the center of the ROI.
20.  The method according to claim 18, wherein driving the at least one motor assembly to position the support structure comprises driving the at least one motor assembly to position the support structure such that at least one of the detectors
moves at least 30 mm during the procedure.
21.  The method according to claim 18, wherein driving the at least one motor assembly to position the support structure comprises driving exactly one motor to position the support structure.
22.  The method according to claim 18, wherein the plurality of rotational orientations includes at least 30 rotational orientations, and wherein driving orientators to orient the detectors comprises driving orientators to orient the detectors
in the at least 30 rotational orientations while the support structure is positioned in each of the plurality of positions.
23.  The method according to claim 18, wherein the plurality of positions includes exactly two or exactly three positions, and wherein driving the at least one motor assembly to position the support structure comprises driving the at least one
motor assembly to position the support structure in the exactly two or exactly three positions, respectively, during two or three respective portions of the procedure, respectively.
24.  The method according to claim 18, wherein driving the at least one motor assembly to position the support structure comprises detecting the positions of the support structure, and, responsively to the detected positions, determining
respective positions of the detectors with respect to the ROI.
25.  The method according to claim 18, wherein driving the at least one motor assembly to position the support structure comprises driving the at least one motor assembly to move the support structure generally around an axis which is
perpendicular to a plane defined by the detectors and passes through the ROI.
26.  The method according to claim 18, wherein performing the radiological imaging procedure comprises performing a SPECT radioimaging procedure.
27.  An imaging system for imaging a region of interest (ROI) of a subject, the system comprising: at least one detector assembly, which comprises: first and second angular orientators;  first and second axial supports, coupled to the first and
second angular orientators, respectfully;  and at least first and second detectors, coupled to the first and second axial supports, respectively, such that the first detector is completely longitudinally offset from the second detector;  and a control
unit, which is configured to: during a first portion of an image acquisition procedure, position the detector assembly in a first longitudinal position with respect to the ROI, and, while the detector assembly is thus positioned, drive the first and
second orientators to orient the first and second axial supports, respectively, in a plurality of rotational orientations with respect to the ROI, and during a second portion of the image acquisition procedure, position the detector assembly in a second
longitudinal position with respect to the ROI, and, while the detector assembly is thus positioned, drive the first and second orientators to orient the first and second axial supports, respectively, in a plurality of rotational orientations with respect
to the ROI.
28.  The system according to claim 27, wherein the first detector has a longitudinal length, and wherein the control unit is configured to position the detector assembly in the first and second longitudinal positions such that a longitudinal
distance between the first and second longitudinal positions equals between 0.8 and 1.2 times the longitudinal length of the first detector.
29.  The system according to claim 27, comprising at least one motor, wherein the control unit is configured to position the detector assembly by driving the at least one motor to move the ROI with respect to the detector assembly.
30.  The system according to claim 27, wherein the detector assembly comprises at least third and fourth detectors, coupled to the first and second axial supports, respectively, such that both the first and third detectors are completely
longitudinally offset from both the second and fourth detectors, and the second detector is positioned longitudinally between the first and third detectors.
31.  An imaging system for performing radiological imaging of a region of interest (ROI) of a subject, the system comprising: at least two detector assemblies, which comprise respective radiation detectors and angular orientators;  a housing;  a
support structure, to which the detector assemblies are coupled, which support structure is coupled to the housing such that the support structure is movable generally around an axis which is perpendicular to a plane defined by the detectors;  at least
one motor assembly, which is coupled to the housing and the support structure, and which is configured to move the support structure with respect to the housing and generally around the axis;  and a control unit, which is configured to perform a
radiological imaging procedure by driving the motor assembly to position the support structure in a plurality of positions with respect to the housing during a respective plurality of portions of the procedure, and while the support structure is
positioned in each of the plurality of positions, driving the orientators to orient the detectors with respect to the ROI.
32.  The system according to claim 31, wherein the axis passes through the ROI, and wherein the support structure is movable generally around the axis that passes through the ROI.
33.  The system according to claim 31, wherein the system is configured to perform a SPECT radioimaging procedure.
34.  An imaging system for performing radiological imaging of a region of interest (ROI) of a subject, the system comprising: a housing;  a support structure, movably coupled to the housing;  at least one motor assembly, coupled to the housing
and the support structure, and configured to move the support structure with respect to the housing;  at least two detector assemblies, coupled to the support structure, and comprising respective radiation detectors and orientators;  and a control unit,
which is configured to perform a radiological imaging procedure by driving the motor assembly to move the support structure with respect to the housing during the procedure, and driving the orientators to orient the detectors with respect to the ROI.
35.  The system according to claim 34, wherein the housing and support structure are configured such that, during the radiological imaging procedure, the support structure moves generally around an axis which is perpendicular to a plane defined
36.  The system according to claim 34, wherein the plane passes through the ROI, and wherein the housing and support structure are configured such that, during the radiological imaging procedure, the support structure moves generally around the
axis which is perpendicular to the plane that passes through the ROI.
37.  The system according to claim 34, wherein the orientators comprise angular orientators, and wherein the orientators are configured to rotationally orient the detectors.
38.  The system according to claim 34, wherein support structure is configured to move with respect to the housing by sliding.
39.  A method for performing radiological imaging of a region of interest (ROI) of a subject, the method comprising performing a radiological imaging procedure by: driving at least one motor assembly to move a support structure with respect to a
housing to which the support structure is movably coupled, which support structure is coupled to at least two radiation detectors;  driving orientators to orient the detectors with respect to the ROI;  and using the detectors, detecting radiation from
40.  The method according to claim 39, wherein driving the at least one motor assembly comprises driving the at least one motor assembly to move the support structure generally around an axis which is perpendicular to a plane defined by the
41.  The method according to claim 40, wherein the axis passes through the ROI, and wherein driving the at least one motor assembly comprises driving the at least one motor assembly to move the support structure generally around the axis that
passes through the ROI.
42.  The method according to claim 39, wherein driving the at least one motor assembly comprises driving the at least one motor assembly to position the support structure in a plurality of positions with respect to the housing during a
respective plurality of portions of the procedure, and wherein driving the orientators comprises driving the orientators comprises driving the orientators to orient the detectors with respect to the ROI while the support structure is positioned in each
of the plurality of positions.
43.  The method according to claim 39, wherein performing the radiological imaging procedure comprises performing a SPECT radioimaging procedure.
44.  The method according to claim 39, wherein the orientators are angular orientators, and wherein driving the orientators comprises driving the angular orientators to rotationally orient the detectors.
U.S.  Pat.  No. 6,242,743 to DeVito et al., which is incorporated herein by reference, describes a tomographic imaging system which images ionizing radiation such as gamma rays or x rays.  The system is described as being capable of producing
tomographic images without requiring an orbiting motion of the detector(s) or collimator(s) around the object of interest and of observing the object of interest from sufficiently many directions to allow multiple time-sequenced tomographic images to be
produced.  The system consists of a plurality of detector modules which are distributed about or around the object of interest and which filly or partially encircle it.  The detector modules are positioned close to the object of interest thereby
improving spatial resolution and image quality.  The plurality of detectors view a portion of the patient or object of interest simultaneously from a plurality of positions.  These attributes are achieved by configuring small modular radiation detector
with high-resolution collimators in a combination of application-specific acquisition geometries and non-orbital detector module motion sequences composed of tilting, swiveling and translating motions, and combinations of such motions.  Various kinds of
module geometry and module or collimator motion sequences are possible.  The geometric configurations may be fixed or variable during the acquisition or between acquisition intervals.
U.S.  Patent Application Publication 2005/0205792 to Rousso et al.
PCT Publication WO 04/042546.  to Kimchy et al.
U.S.  Pat.  Nos.  5,939,724, 5,587,585, and 5,365,069 to Eisen et al.
U.S.  Pat.  No. 6,943,355 to Shwartz et al.
U.S.  Pat.  No. 5,757,006 to DeVito et al.
U.S.  Pat.  No. 6,137,109 to Hayes
U.S.  Pat.  No. 6,388,258 to Berlad et al.
U.S.  Pat.  No. 6,429,431 to Wilk
U.S.  Pat.  No. 6,838,672 to Wagenaar et al.
U.S.  Pat.  Nos.  6,740,882, 6,545,280, 6,229,145, 5,519,221, 5,252,830, and 6,628,984 to Weinberg
U.S.  Pat.  No. 6,713,766 to Garrard et al.
U.S.  Pat.  No. 6,765,981 to Heumann
U.S.  Pat.  No. 6,664,542 to Ye et al.
U.S.  Pat.  No. 6,080,984 to Friesenhahn
U.S.  Pat.  No. 5,818,050 to Dilmanian et al.
U.S.  Pat.  No. 6,728,583 to Hallett
U.S.  Pat.  No. 5,481,115 to Hsieh et al.
U.S.  Pat.  No. 6,723,988 to Wainer
U.S.  Pat.  No. 6,940,070 to Tumer
U.S.  Pat.  No. 6,635,879 to Jimbo et al.
U.S.  Pat.  No. 6,353,227 to Boxen
U.S.  Pat.  No. 6,184,530 to Hines et al.
U.S.  Pat.  No. 5,813,985 to Carroll
In embodiments of the present invention, an imaging system comprises a plurality of detector assemblies, each of which comprises a detector coupled to an angular orientator.  Each of the detectors comprises a plurality of gamma ray sensors and at
least one collimator.  A control unit drives, typically separately, each of the orientators to orient its respective detector in a plurality of rotational orientations with respect to a region of interest (ROI) of a subject.  The control unit produces an
image, typically a SPECT image, from a plurality of radiation acquisitions acquired with the detectors in different relative orientations.
In typical implementations of the imaging system, the detector assemblies are laterally spaced apart from one another because of physical constraints, such as the width and depth of the detectors.  Such spacing causes reduced detection of photons
emitted from certain areas of the ROI, particularly areas neat the surface of the subject&#39;s body, which are near the detectors.
In some embodiments of the present invention, each of the detectors is coupled to a respective translator.  During an image acquisition procedure, the control unit drives each of the translators to position its respective detector in a plurality
of lateral positions, such as two lateral positions.  While each detector is in each of its respective lateral positions, the control unit drives the respective orientator to orient the detector in a plurality of rotational orientations with respect to
the ROI.  The combination of such lateral translatory motion and rotational motion increases the number of angles from which photons emitted from the ROI are detected particularly in areas of the ROI near the surface of the subject&#39;s body.
For some applications, during a first portion of an imaging procedure, each of the detectors is positioned in a first lateral position, and during a second portion of the imaging procedure, the detector is positioned in a second lateral position. The distance between the first and second positions is typically about 50% of the distance between the rotational axis of the detector and that of a neighboring detector, such as between about 40% and about 60% of the distance.  The positioning of the
detectors in both positions increases the number of angles from which photons emitted from the ROI are detected, thereby improving photon detection counts for areas of the ROI near the surface of the subject&#39;s body.
In some embodiments of the present invention, the camera comprises a support structure, to which the detector assemblies are coupled.  The camera comprises a housing, which is shaped so as to define a cavity, in which the support structure is
positioned.  The housing generally is configured to remain stationary throughout an imaging procedure.  In order to position each of the detector assemblies in a plurality of lateral positions, the control unit drives one or more motors to move the
support structure within the cavity.  The camera comprises at least one variable-length motor assembly (typically exactly one variable-length motor assembly), which is configured to move the support structure with respect to the housing by changing a
length of the assembly.  The motor assembly typically further comprises a first pivoting post, which is coupled to the support structure, and a second pivoting post, which is coupled to the housing.  The use of this single-support frame configuration
enables the use of a single motor assembly for simultaneously positioning all of the detector assemblies at precise locations with respect to each other and a coordinate system of the camera.
In some embodiments of the present invention, the imaging system comprises at least one detector assembly, which comprises first and second axial supports, which are coupled to respective angular orientators.  The assembly further comprises at
least one first detector coupled to the first axial support, and at least one second detector coupled to the second axial support.  The first and second detectors are arranged along the axial supports such that the first detector is completely
longitudinally offset from the second detector.  For some applications, the assembly further comprises a third detector, coupled to the first axial support, and a fourth detector, coupled to the second axial support, and the detectors are arranged in a
As a result of this offset arrangement, the detectors are able to be positioned laterally closer to one another than is possible using arrangements having a single elongated detector per angular orientator.  However, the assembly has detection
gaps in the longitudinal regions of each axial support to which no detector is coupled.  To compensate for these gaps, the camera is configured to position the detector assembly in a first longitudinal position with respect to an ROI during a first
portion of an image acquisition procedure, and in a second longitudinal position with respect to the ROI during a second portion of the procedure.  A longitudinal distance between the first and second longitudinal positions typically equals approximately
a longitudinal length of one of the detectors.  While the assembly is in each of the longitudinal positions, the control unit drives the orientators to orient their respective detectors in a plurality of rotational orientations with respect to the ROI.
As a result the entire ROI opposite the assembly is covered by the assembly in one of its two longitudinal positions with respect to the ROI.
while the support structure is positioned in each of the plurality of positions, driving the orientators to orient the respective detectors in a plurality of rotational orientations with respect to the ROI, and to detect radiation from the ROI at
least a portion of the rotational orientations.
Typically, the housing and the support structure are configured such that, throughout the procedure, a furthest distance of all of the detectors from a center of the ROI throughout the procedure is less than 120% of a closest distance of all of
the detectors from the center of the ROI.
For some applications, the at least two detector assemblies include at least five detector assemblies.  For some applications, the control unit is configured to drive the motor assembly to position the support structure such that at least one of
the detectors moves at least 30 mm during the procedure.
For some applications, the plurality of rotational orientations includes at least 30 rotational orientations, and the control unit is configured to drive the orientators to orient the respective detectors in the at least 30 rotational
orientations while the support structure is positioned in each of the plurality of positions.
For some applications, the plurality of positions includes exactly two positions, and the control unit is configured to drive the motor to position the support structure in the two positions during two respective portions of the procedure.
Alternatively or additionally, the plurality of positions includes exactly three positions, and the control unit is configured to drive the motor to position the support structure in the three positions during three respective portions of the procedure.
For some applications, the support structure is generally L-shaped.  For some applications, the support structure is substantially rigid.
For some applications, the motor assembly includes a position encoder configured to generate a position signal, and the control unit is configured to determine, responsively to the position signal, respective positions of the detectors with
respect to the ROI.  Typically, none of the detector assemblies includes a position sensor.
For some applications, the housing and support structure are configured such that, during the radioimaging procedure, the support structure moves generally around an axis which is perpendicular to a plane defined by the detectors and passes
through the ROI.
during a plurality of portions of the procedure, positioning a support structure in a respective plurality of positions with respect to a housing to which the support structure is movably coupled, which housing is fixed to at least two radiation
while the support structure is positioned in each of the plurality of positions, orienting the detectors in a plurality of rotational orientations with respect to the ROI, and, using the detectors, detecting radiation from the ROI at least a
portion of the rotational orientations.
during a first portion of an image acquisition procedure, drive the first and second translators to position the first and second detectors in first and second lateral positions, respectively, and while the detectors are thus positioned, drive
the first and second orientators to orient the first and second detectors, respectively, in a plurality of rotational orientations with respect to the ROI, and
during a second portion of the image acquisition procedure, drive the first and second translators to position the first and second detectors in third and fourth lateral positions, respectively, and, while the detectors are thus positioned, drive
the first and second orientators to orient the first and second detectors, respectively, in a plurality of rotational orientations with respect to the ROI.
In an embodiment, the first and second detectors have respective rotational axes, when the first and second detectors are positioned in the first and second lateral positions, respectively, the respective rotational axes of the first second
detectors have an inter-detector distance, and when the first and second detectors are positioned in the third and fourth lateral positions, a distance between the rotational axis of the first detector when in the first and third positions is between 40%
and 60% of the inter-detector distance.
during a first portion of an image acquisition procedure, position the detector assembly in a first longitudinal position with respect to the ROI, and, while the detector assembly is thus positioned, drive the first and second orientators to
orient the first and second axial supports, respectively, in a plurality of rotational orientations with respect to the ROI, and
during a second portion of the image acquisition procedure, position the detector assembly in a second longitudinal position with respect to the ROI, and, while the detector assembly is thus positioned, drive the first and second orientators to
orient the first and second axial supports, respectively, in a plurality of rotational orientations with respect to the ROI.
In an embodiment, the first detector has a longitudinal length, and the control unit is configured to position the detector assembly in the first and second longitudinal positions such that a longitudinal distance between the first and second
longitudinal positions equals between 0.8 and 1.2 times the longitudinal length of the first detector.
In an embodiment, the system includes at least one motor, and the control unit is configured to position the detector assembly by driving the at least one motor to move the detector assembly with respect to the ROI.  Alternatively, the control
unit is configured to position the detector assembly by driving the at least one motor to move the ROI with respect to the detector assembly.
For some applications, the detector assembly includes at least third and fourth detectors, coupled to the First and second axial supports, respectively, such that both the first and third detectors are completely longitudinally offset from both
the second and fourth detectors, and the second detector is positioned longitudinally between the first and third detectors.
FIG. 1 is a schematic illustration of an imaging system 10, in accordance with an embodiment of the present invention.  Imaging system 10 comprises a control unit 20, a camera 22, and an imaging workstation 24.  Typically, control unit 20 and
imaging workstation 24 comprise one or more standard personal computers or servers with appropriate memory, communication interfaces and software for carrying out the functions prescribed by relevant embodiments of the present invention.  This software
may be downloaded to the control unit and imaging workstation in electronic form over a network, for example, or it may alternatively be supplied on tangible media, such as CD-ROM.
Control unit 20 typically comprises: (a) image acquisition functionality, which is configured to drive camera 22 to perform image acquisition of the patient; (b) image reconstruction functionality, which is configured to perform an image
reconstruction procedure on the acquired image; (c) image analysis functionality, which is configured to perform an image analysis procedure on the reconstructed image; and (d) diagnosis functionality, which is configured to perform a diagnostic
procedure using the results of the image analysis procedure.  It will be appreciated that control unit 20 may comprise a plurality of personal computers or servers, each of which performs one or more of these procedures, and that one or more of these
computers or servers may be located remotely from camera 22.  Imaging workstation 24 displays the reconstructed images and allows the attending healthcare worker to view and manipulate the images.
For some applications, camera 22 utilizes techniques described in the above-mentioned PCT Publications WO 06/051531 and/or: WO 05/119025, and/or in the other co-assigned patent applications and/or patent application publications incorporated
In an embodiment of the present invention, camera 22 comprises a plurality of detector assemblies 30, each of which comprises a detector 32 coupled to an angular orientator 34.  Each of the detectors comprises a plurality of gamma ray sensors,
such as a pixelated array of crystals, e.g., CZT crystals, and at least one collimator.  For example, the array may comprise 16.times.64 pixels, arranged in sub-arrays of 16.times.16 pixels.  Detector assemblies 30 are arranged at least partially around
a region of interest (ROI) of subject 36.
Reference is made to FIG. 2, which is a schematic cross-sectional illustration of a portion of camera 22 placed partially around an ROI 40 of subject 36, in accordance with an embodiment of the present invention.  During an image acquisition
procedure, control unit 20 drives, typically separately, each of orientators 34 to orient its respective detector 32 in a plurality of rotational orientations with respect to ROI 40.  Control unit 20 produces an image, typically, but not necessarily, a
SPECT image, from a plurality of radiation acquisitions acquired with detectors 32 in different relative orientations.
For each of detectors 32, FIG. 2 shows a ray 42, which schematically represents the fill angular range of photon detection of the detector, as determined by the angular orientations in which the detector&#39;s orientator 34 orients the detector, and
the collimation of the detector.  Each ray 42 schematically represents the combination of the plurality of distinct angular orientations at which the corresponding detector is oriented during an imaging procedure.  For example, a detector may be oriented
at 60 distinct angular orientations, each of which is separated by one degree, with a dwell time of one or two seconds at each orientation, such that the total angular range is 60 degrees, and the total scan time is 60 or 120 seconds, respectively.
Alternatively, a detector may be oriented at fewer or greater than 60 distinct angular orientations, which are separated by less or more than one degree, with a dwell time of any number of seconds at each orientation.  For some applications, camera 22 is
configured to individually set a total angular range of each of detectors 32 responsively to the detector&#39;s orientation with respect to ROI 40.  For example, techniques may be used that are described in an international patent application filed May 11,
2006, entitled, &quot;Unified management of radiopharmaceuticals dispensing, administration, and imaging,&quot; which is assigned to the assignee of the present application and is incorporated herein by reference.  For some applications, the detector is oriented
at each of the distinct angular orientations as the detector sweeps in a single direction.  Alternatively, the detector is oriented at only a portion, e.g., half, of the distinct angular orientations as the detector sweeps in a first direction, and the
detector is orientated at the remaining distinct angular orientations as the detector sweeps back in a second direction opposite the first direction.
In typical implementations of camera 22, detector assemblies 30 are laterally spaced apart from one another because of physical constraints, such as the width and depth of detectors 32.  Such spacing causes reduced detection of photons emitted
from certain areas of ROI 40, particularly areas near the surface of the subject&#39;s body, which are near the detectors.  As can be seen in FIG. 2, gamma rays emitted from certain points within ROI 40, such as a centrally-located point A, may be detected
by any of detectors 32, while gamma rays emitted from other points within ROI 40, such as a point B located near the periphery of ROI 40, may be detected by only a single detector 32 (ignoring potential scattering).  Gamma rays emitted from still other
points, such as a point C, cannot be detected by any of the detectors (again, ignoring potential scattering).
Reference is made to FIGS. 3A-B, which are schematic illustrations of detector assembly 30 configured for translatory motion, in accordance with an embodiment of the present invention.  In this embodiment, each of detector assemblies 30 comprises
a translator 50, which is configured to position detector 32 in a plurality of lateral positions.  For example, translator 50 may comprise a track 52 and a support element 54 that slides along the track.  Support element 54 typically comprises angular
orientator 34.  Other configurations for effecting translatory motion will be evident to those skilled in the art who have read the present application, and are within the scope of the present invention.
During an image acquisition procedure, control unit 20 drives each of translators 50 to position its respective detector 32 in a plurality of lateral positions, such as two lateral positions (e.g., as shown in FIGS. 3A and 3B, respectively).  (An
arrow 56 in FIG. 2 symbolically illustrates the approximate directions of lateral motion of a detector assembly 58.) While each detector 32 is in each of its respective lateral positions, control unit 20 drives the respective orientator 34 to orient the
detector in a plurality of rotational orientations with respect to the ROI.  The combination of such lateral translatory motion and rotational motion increases the number of angles from which photons emitted from the ROI are detected, particularly in
areas of the ROI near the surface of the subject&#39;s body.
For some applications, control unit 20 drives each of translators 50 positions its respective detector in more than two lateral positions.  For some applications, (a) the number of lateral positions of each detector and (b) the number of
detectors (and corresponding number of detector assemblies) are selected such that the product of (a) and (b) equals a certain desired number of total lateral positions, e.g., between about 10 and about 30, such as between about 15 and about 25, e.g.,
about 18 positions.  For example, if a total of 18 positions is desired, six detectors may be provided, in which case the number of lateral positions of each detector would be three.  In current implementations, typically six or nine detectors are
provided, with a corresponding number of positions per detector of three or two, respectively.
For some applications, during a first portion of an imaging procedure, each of the detectors is positioned in a first lateral position, and during a second portion of the imaging procedure, the detector is positioned in a second lateral position. The distance between the first and second positions is typically about 50% of the distance between the rotational axis of the detector and that of the neighboring detector, such as between about 40% and about 60% of the distance.  The positioning of the
detectors in both positions increases the number of angles from which photons emitted from the ROI are detected, thereby improving photon detection counts for areas of the ROI near the surface of the subject&#39;s body.  For some imaging protocols, each of
the detectors is positioned in the first and second lateral positions a plurality of times.
For some applications, fewer than all of detector assemblies 30 are configured for translatory motion.  For example, one or more of the detector closer to the ROI (a &quot;proximal detector&quot; or an &quot;inner detector&quot;) may be configured for translatory
motion, while one or more of the detectors further from the ROI (a &quot;distal detector&quot; or an &quot;outer detector&quot;) may be configured for only rotational motion.
For some applications, at least some of detectors 32 or detector assemblies 30 are configured to rotate around a horizontal axis, such as a horizontal axis 59 (assuming that orientators 34 rotate detectors 32 around a vertical axis).  For some
applications, control unit 22 rotates the detector assemblies around the their respective horizontal axes during an image acquisition procedure.  For example, the control unit may perform a preliminary scan with the detectors at first respective
rotations, and a subsequent higher-resolution scan with the detectors at second respective rotations.  For some applications, the detector assemblies are fixed at differing rotational angles around their respective horizontal axes.
Reference is again made to FIG. 1.  In an embodiment of the present invention, imaging system 10 effects lateral motion of detector assemblies 30 with respect to subject 36 by moving the entire camera 22, or a gantry thereof with respect to the
subject.  For example, the system may rotate the camera, or a gantry thereof, e.g., about an axis 60 that passes through a curved region 62 of the camera and is generally parallel to the longitudinal axes of detector assemblies 30 (and with a
longitudinal axis of subject 36 in a vicinity of the ROI).  Alternatively, the system moves, e.g., rotates, subject 36 with respect to the camera, which remains stationary.
For some applications, imaging system 10 rotates camera 22, or a gantry thereof, around an axis 64 that is generally perpendicular to axis 60 and parallel with a plane defined by a subject support structure 130 in a vicinity of the ROI.  Such
rotation has an effect (at least for a portion of the detectors) similar to that of the individual rotation of detectors 32 or detector assemblies 30 around horizontal axis 59, as described hereinabove with reference to FIGS. 3A-B.
Reference is made to FIGS. 4A-C and 5A-B, which are schematic top-view illustrations of a configuration of camera 22, in accordance with respective embodiments of the present invention.  In this embodiment, camera 22 comprises a support structure
200, to which detector assemblies 30 are coupled.  In the embodiments shown in the figures, support structure 200 is generally L-shaped.  Alternatively, the support structure has another shapes, such as an arc, e.g., of between about 60 and 360 degrees,
such as about 90 to 180 degrees, e.g., between 60 and 120 degrees.  For some applications, as shown in FIGS. 4A-C and 5A-B, support structure 200 is substantially rigid, while for other applications, the support structure comprises joints that impart
flexibility to the support structure (configuration not shown).  Camera 22 (typically an arm thereof) comprises a housing 210, which is shaped so as to define a cavity 212, in which support structure 200 is positioned.  The housing generally is
configured to remain stationary throughout an imaging procedure.  In order to position each of the detector assemblies in a plurality of lateral positions, control unit 20 drives one or more motors to move support structure 200 within cavity 212.  The
one or more motors are described in detail hereinbelow with reference to FIG. 6.  Cavity 212 is large enough to accommodate support structure 200 in its various orientations as it rotates through the cavity.
During an imaging procedure, support structure 200 moves generally around an axis which is perpendicular to a plane defined by the detectors and passes through the ROI (such as axis 60, shown in FIG. 1).  Because of this motion generally around
the axis, the distances of the detectors from the ROI do not generally vary substantially as the support structure moves.  In other words, the housing and the support structure are configured such that a furthest distance of all of the detectors from a
center of the ROI throughout an imaging procedure is less than 120% of a closest distance of all of the detectors from the center of the ROI throughout the procedure, e.g., less than 110%
In the embodiment shown in FIGS. 4A-C, camera 22 comprises six detector assemblies 30, which the control unit positions in three respective lateral positions by moving support structure 200, shown in FIGS. 4A, 4B, and 4C, respectively.  In the
embodiment shown in FIGS. 5A-B, the camera comprises nine assemblies, which the control unit positions in two respective positions by moving support structure 200, shown in FIGS. 5A and 5B, respectively.  As described hereinabove with reference to FIGS.
3A-B, the number of detector assemblies and positions are sometimes selected such that a product thereof equals a desired number of total lateral positions; in the examples shown in FIGS. 4A-C and 5A-B, the total number of lateral positions is 18.  The
positioning of the detectors in the plurality of positions increases the number of angles from which photons emitted from the ROI are detected, thereby improving photon detection counts for areas of the ROI near the surface of the subject&#39;s body.  For
some imaging protocols, each of the detectors is positioned in each of the plurality of positions a plurality of times.
For some applications, at a first point in time of an imaging procedure, a first detector assembly is positioned at a first initial detector assembly lateral position, and a second detector assembly neighboring the first detector assembly is
positioned at a second initial detector assembly lateral position.  The control unit moves the support structure such that, at one or more second points in time, the first detector assembly assumes one or more respective intermediate positions between
the first initial detector assembly lateral position and the second initial detector assembly lateral position, typically not reaching the second initial detector assembly lateral position.  For example, for applications in which the support structure is
placed for imaging at exactly two support structure lateral positions during the imaging procedure, the control unit may move the support structure such that: (a) when the support structure is positioned at a first of the exactly two support structure
lateral positions, the first detector assembly is positioned at the first initial detector assembly lateral position, and (b) when the support structure is positioned at a second of the exactly two support structure lateral positions, the first detector
assembly is positioned at an intermediate location between 40% and 60% of the distance between the first and second initial detector assembly lateral positions, e g., 50%.  Similarly, for applications in which the support structure is placed for imaging
at exactly three support structure lateral positions during the imaging procedure, the two intermediate positions are typically between 23% and 43% (e.g., 33.3%), and 57% and 77% (e.g., 66.7%), respectively, of the distance between the first and second
initial detector assembly lateral positions.
Reference is made to FIG. 6, which is a schematic bottom-view illustration of the nine-detector configuration of camera 22 shown in FIGS. 5A-B, in accordance with an embodiment of the present invention.  Camera 22 comprises at least one
variable-length motor assembly 218 (typically exactly one variable-length motor assembly), which is configured to move support structure 200 with respect to housing 210 by changing a length of assembly 218.  Motor assembly 218 comprises a motor 220,
which typically comprises a linear stepper motor.  For some applications, the motor comprises a DC motor with an integrated gear and linear position encoder.  Motor assembly 218 typically further comprises a first pivoting post 222, which is coupled to
support structure 200, and a second pivoting post 224, which is coupled to housing 210.  For some applications, motor assembly further comprises a zero-backlash lead screw mechanism 226.
The linear position encoder measures the position of the motor, thereby enabling control unit 20 to determine the length of motor assembly 218 and the lateral position of support structure 200.  Using this position information, the control unit
determines the lateral positions of each detector assembly 30 and detector 32.  Typically, a calibration procedure is performed during or after manufacture of camera 22 to determine the precise locations of each detector assembly 30 and detector 32 for
each position value output by the linear position encoder.
Support structure 200, housing 210, and motor assembly 218 are typically configured to provide a total lateral range of motion of support structure 200 of between about 30 mm and about 60 mm, e.g., between about 40 mm and about 50 mm, with a
radius of between about 20 mm and about 25 mm.
Reference is again made to FIGS. 5A and 6.  For some applications, support structure 200 comprises an upper support frame 260, shown in FIG. 5A, and a lower support frame 262, shown in FIG. 6, which together support detector assemblies 30 from
the top and bottom.  For some applications, upper support frame 260 slides along an upper rail, and lower support frame 262 slides along lower rail, a portion 270 of which is shown in FIG. 6.
For some applications, the embodiments described with reference to FIGS. 4A-6 arc practiced with techniques described herein with reference to FIGS. 1, 2, 3A-3B, and/or 7A-B, mutatis mutandis.  For example, the lateral and angular motion patterns
described hereinabove with reference to FIG. 2 are typically used.
The use of the single-support frame configuration of the embodiments described with reference to FIGS. 4A-6 enables the use of a single motor assembly for simultaneously positioning all of detector assemblies 30 at precise locations with respect
to each other and a coordinate system of camera 22.  The use of the linear position encoder enables precise determination of all of the detector assemblies without requiring separate position sensors for each detector assembly.
Reference is made to FIGS. 7A-B, which are schematic illustrations of a detector assembly 100, in accordance with respective embodiments of the present invention.  Imaging system 10 comprises at least one detector assembly 100, which comprises
two axial supports 110A and 110B, which are coupled to respective angular orientators 112A and 112B.  The assembly further comprises one or more detectors 114A coupled to axial support 110A, and one or more detectors.  114B coupled to axial support 110B. In the embodiment shown in FIG. 7A, assembly 100 comprises two detectors 114A and two detectors 114B, and in the embodiment shown in FIG. 7B, the assembly comprises a single detector 114A and a single detector 114B.  Alternatively, the assembly comprises
more than two detectors 114A and more than two detectors 114B.
Detectors 114A and 114B are arranged along axial supports 110A and 110B such that all of the one or more detectors 114A are completely longitudinally offset from all of the one or more detectors 114B.  In other words, no portion of any detector
114A occupies the same longitudinal position as any portion of any detector 114B.  For example, the detectors shown in FIG. 7A are arranged in a checkerboard pattern.
As a result of this offset arrangement, detectors 114A and 114B are able to positioned laterally closer to one another than is possible in the arrangements shown in FIGS. 1, 2, and 3A-B. However, assembly 100 has detection gaps in the
longitudinal regions of each axial support to which no detector is coupled, such as region 120 of axial support 110A.  To compensate for these gaps, camera 22 is configured to position detector assembly 100 in a first longitudinal position with respect
to an ROI during a first portion of an image acquisition procedure, and in a second longitudinal position with respect to the ROI during a second portion of the procedure.  A longitudinal distance between the first and second longitudinal positions
typically equals approximately a longitudinal length L of one of the detectors, i.e., +/-20% of length L. While the assembly is in each of the longitudinal positions, control unit 20 drives orientators 110A and 110B to orient detectors 114A and 114B,
respectively, in a plurality of rotational orientations with respect to the ROI.  As a result, the entire ROI opposite assembly 100 is covered by the assembly in one of its two longitudinal positions with respect to the ROI.
For some applications, camera 22 is configured to longitudinally position the assemblies with respect to the ROI by moving the assemblies, either individually, or as a group by moving camera 22 (or a gantry thereof) to which the assemblies are
coupled.  For other applications, camera 22 is configured to longitudinally position the assemblies with respect to the ROI by moving the ROI, i.e., by moving the subject longitudinally.  For example, the camera may move subject support structure 130,
such as a bed upon which the subject is lying, or a chair upon which the subject is sitting (subject support structure 130 is shown in FIG. 1).
For some applications, when driving orientators 110A and 110B to orient detectors 114A and 114B, respectively, in a plurality of rotational orientations with respect to the ROI, control unit 20 drives one of the orientators to rotate its
respective detector(s) in a first rotational direction, while driving the other of the orientators to rotate its respective detector(s) in a second rotational direction opposite the first direction.  Alternatively, the control unit drives both of the
orientators to rotate their respective detectors in the same rotational direction.  In either case, the control unit typically drives the orientators to rotate their respective detectors in the remaining direction(s) after the assembly has been
positioned in the other longitudinal position.
As described hereinabove with reference to FIGS. 3A-B regarding detector assemblies 30, for some applications, at least some of detectors 114 or detector assemblies 100 are configured to rotate around a horizontal axis (assuming that orientators
112 rotate detectors 114 around a vertical axis).  For some applications, the control unit rotates the detector assemblies around the their respective horizontal axes during an image acquisition procedure.  For example, the control unit may perform a
preliminary scan with the detectors at first respective rotations, and a subsequent higher-resolution scan with the detectors at second respective rotations.  For some applications, the detector assemblies are fixed at differing rotational angles around
their respective horizontal axes.
For some applications in which each of the detectors comprises a plurality of gamma ray sensors, such as a pixelated array of crystals, e.g., CZT crystals, each of the detectors comprises a square array of pixels, e.g., a 16.times.16 array, as
shown in FIG. 7A.  For these applications, assembly 100 may comprise, for example, two detectors 114A and two detectors 114B.  Alternatively, for some applications, each of the arrays comprises a rectangular array of pixels, for example, an array having
a longitudinal length L that is equal to twice a width W of the array e.g., a 32.times.16 array, as shown in FIG. 7B.  Further alternatively, the ratio of the length L to the width W is greater than 2:1, such as 4:1, e.g., a 64.times.16 array
(configuration not shown).
The scope of the present invention includes embodiments described in the following applications, which are assigned to the assignee of the present application and are incorporated herein by reference.  In an embodiment, techniques and apparatus
described in one or more of the following applications are combined with techniques and apparatus described herein:
an international patent application filed May 11, 2006, entitled, &quot;Unified management of radiopharmaceutical dispensing, administration, and imaging&quot;;
International Patent Application PCT/IL2005/001173, filed Nov.  9, 2005, which published as PCT Publication WO 06/051531;
International Patent Application PCT/IL2005/000572, filed Jun.  1, 2005;
International Patent Application PCT/IL2005/000575, filed Jun.  1, 2005;
International Patent Application PCT/IL2005/001215, filed Nov.  16, 2005, which published as PCT Publication WO 06/054296;
U.S.  Provisional Patent Application 60/625,971, filed Nov.  9, 2004;
U.S.  Provisional Patent Application 60/628,105, filed Nov.  17, 2004;
U.S.  Provisional Patent Application 60/630,561, filed Nov.  26, 2004;
U.S.  Provisional Patent Application 60/632,236, filed Dec.  2, 2004;
U.S.  Provisional Patent Application 60/632,515, filed Dec.  3, 2004; .
U.S.  Provisional Patent Application 60/635,630, filed Dec.  14, 2004;
U.S.  Provisional Patent Application 60/636,088, filed Dec.  16, 2004;
U.S.  Provisional Patent Application 60/640,215, filed Jan.  3, 2005;
U.S.  Provisional Patent Application 60/648,385, filed Feb.  1, 2005;
U.S.  Provisional Patent Application 60/648,690, filed Feb.  2, 2005;
U.S.  Provisional Patent Application 60/675,892, filed Apr.  29, 2005;
U.S.  Provisional Patent Application 60/691,780, filed Jun.  20, 2005;
U.S.  Provisional Patent Application 60/700,318, filed Jul.  19, 2005;
U.S.  Provisional Patent Application 60/700,299, filed Jul.  19, 2005;
U.S.  Provisional Patent Application 60/700,317, filed Jul.  19, 2005;
U.S.  Provisional Patent Application 60/700,753, filed Jul.  20, 2005;
U.S.  Provisional Patent Application 60/700,752, filed Jul.  20, 2005;
U.S.  Provisional Patent Application 60/702,979, filed Jul.  28, 2005;
U.S.  Provisional Patent Application 60/720,034, filed Sep. 26, 2005;
U.S.  Provisional Patent Application 60/720,652, filed Sep. 27, 2005;
U.S.  Provisional Patent Application 60/720,541, filed Sep. 27, 2005;
U.S.  Provisional Patent Application 60/750,287, filed Dec.  13, 2005;
U.S.  Provisional Patent Application 60/750,334, filed Dec.  15, 2005;
U.S.  Provisional Patent Application 60/750,597, filed Dec.  15, 2005;
U.S.  Provisional Patent Application 60/799,688, filed May 11, 2006;
U.S.  Provisional Patent Application 60/800,845, filed May 17, 2006, entitled, &quot;Radioimaging camera for dynamic studies&quot;;
U.S.  Provisional Patent Application 60/800,846 filed May 17, 2006, entitled, &quot;Radioimaging protocols&quot;;
U.S.  Provisional Patent Application 60/763,458, filed Jan.  31, 2006;
U.S.  Provisional Patent Application 60/741,440, filed Dec.  2, 2005;
U.S.  Provisional Patent Application 11/034,007, filed Jan.  13, 2005;
U.S.  Provisional Patent Application 09/641,973, filed Aug.  21, 2000;
U.S.  Provisional Patent Application 60/750,294, filed Dec.  13, 2005 (this application has not been assigned to the assignee of the present application; an assignment is in the process of being executed and filed);
U.S.  Provisional Patent Application 60/816,970, filed Jun.  28, 2006;
International Patent Application PCT/IL2006/000059, filed Jan.  15, 2006;
International Patent Application PCT/IL2005/000048, filed Jan.  13, 2005;
International Patent Application PCT/IL03/00917, filed Nov.  4, 2003;
Israel Patent Application 172349, filed Nov.  27, 2005;
Israel Patent Application 171346, filed Oct.  10, 2005;
International Patent Application PCT/IL2006/001511, filed Dec.  28, 2006;
International Patent Application PCT/IL2006/001291, filed Nov.  29, 2006;
International Patent Application PCT/IL2006/000834, filed Jul.  19, 2006;
International Patent Application PCT/IL2006/000840, filed Jul.  19, 2006;
U.S.  Provisional Patent Application 60/754,199, filed Dec.  28, 2005;
U.S.  patent application Ser.  No. 11/607,075, filed Dec.  1, 2006;
U.S.  patent application Ser.  No. 11/656,548, filed Jan.  13, 2005;
U.S.  patent application Ser.  No. 10/533,568, filed Nov.  4, 2003; and/or
U.S.  patent application Ser.  No. 11/750,057, filed May 17, 2007.
Imaging techniques for reducing blind spots, Ben-Haim, et al., Shlomo Ben-Haim, Haim Melman, Michael Nagler, Benny Rousso, Yoel Zilberstien, Sajed Haj-Yahya, Application number 11 769-826, Radiant Energy, IMAGING TECHNIQUES, phase shift, PATENT NUMBER, Patent application, EUV light, inventive concept, Work File, interference fringe, incident angle, control unit
The present invention relates generally to radiological imaging techniques, and specifically to apparatus and methods for positioning detectors of radiological imaging systems.BACKGROUND OF THE INVENTIONPCT Publication WO 06/051531 to Rousso et al., which is assigned to the assignee of the present application and is incorporated herein by reference, describes radioimaging methods, devices and radiopharmaceuticals.U.S. Pat. No. 6,242,743 to DeVito et al., which is incorporated herein by reference, describes a tomographic imaging system which images ionizing radiation such as gamma rays or x rays. The system is described as being capable of producingtomographic images without requiring an orbiting motion of the detector(s) or collimator(s) around the object of interest and of observing the object of interest from sufficiently many directions to allow multiple time-sequenced tomographic images to beproduced. The system consists of a plurality of detector modules which are distributed about or around the object of interest and which filly or partially encircle it. The detector modules are positioned close to the object of interest therebyimproving spatial resolution and image quality. The plurality of detectors view a portion of the patient or object of interest simultaneously from a plurality of positions. These attributes are achieved by configuring small modular radiation detectorwith high-resolution collimators in a combination of application-specific acquisition geometries and non-orbital detector module motion sequences composed of tilting, swiveling and translating motions, and combinations of such motions. Various kinds ofmodule geometry and module or collimator motion sequences are possible. The geometric configurations may be fixed or variable during the acquisition or between acquisition intervals.The following patents and patent application publications, which describe gamma cameras and imaging processing techniques, and which are incorporated herei
Blind Spots Chapter
Blind Spots systems and future market trends PReVENT