Source: http://www.google.com/patents/US4966777?dq=5251294
Timestamp: 2013-12-10 05:29:15
Document Index: 312566051

Matched Legal Cases: ['art 1', 'art 2', 'art 3', 'art 4', 'art 1', 'art 2', 'arts 1', 'arts 3']

Patent US4966777 - Anticalculus oral composition - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Advanced Patent Search | Sign inAdvanced Patent SearchPatentsAn oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophosphate,...http://www.google.com/patents/US4966777?utm_source=gb-gplus-sharePatent US4966777 - Anticalculus oral compositionPublication numberUS4966777 APublication typeGrantApplication numberUS 07/455,713Publication dateOct 30, 1990Filing dateDec 21, 1989Priority dateSep 13, 1985Fee statusPaidAlso published asUS8535730Publication number07455713, 455713, US 4966777 A, US 4966777A, US-A-4966777, US4966777 A, US4966777AInventorsRosemarie M. Crisafulli, Robert J. Ferlauto, Jr., Abdul Gaffab, Thomas G. PolefkaOriginal AssigneeColgate-Palmolive CompanyExport CitationBiBTeX, EndNote, RefManPatent Citations (50), Non-Patent Citations (7), Referenced by (13), Classifications (17), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetAnticalculus oral compositionUS 4966777 AAbstract An oral dentifrice composition such as a toothpaste, dental gel, toothpowder, dental tablet or lozenge containing as anticalculus agent about 4.3% to about 7% of alkali metal pyrophosphates comprising at least 4.3% of tetrapotassium pyrophosphate alone or admixed with up to 2.7% of tetrasodium pyrophosphate, and as inhibitors against enzymatic hydrolysis of such agent in saliva, a fluoride and preferably up to about 3% of a synthetic anionic polymeric polycarboxylate, and use of such composition in a program of oral hygiene and/or for inhibiting dental calculus.
We claim: 1. In an oral composition containing an orally acceptable aqueous vehicle and, in approximate weight amounts and proportions,A. a mixture of tetrasodium pyrophosphate and tetrapotassium pyrophosphate as effective anticalculus agent, and B. an amount of a fluoride ion source sufficient to supply 25 ppm to 5,000 ppm of fluoride ions, the improvement in which the tetrapotassium pyrophosphate is a predominant portion of said mixture, which portion is sufficient to inhibit the occurrence of solid gritty particles of tetrasodium pyrophosphate in the composition. 2. The composition of claim 1 further containing an amount up to 0.4% of dialkali metal pyrophosphate effective to assist in achieving the desired anticalculus and cosmetic properties.
3. The composition of claim 1 further containing an amount up to 1% of dialkali metal pyrophosphate effective to assist in achieving the desired anticalculus and cosmetic properties.
4. The composition of claim 1 further containing an orally acceptable silica abrasive.
5. The composition of claim 4 in which the fluoride ion source comprises sodium fluoride.
6. The composition of claim 4 in which the fluoride ion source comprises sodium monofluorophosphate.
7. The composition of claim 1 in which the fluoride ion source comprises sodium fluoride.
8. The composition of claim 1 in which the fluoride ion source comprises sodium monofluorophosphate.
9. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 1.
10. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 2.
11. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 3.
12. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 4.
13. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 5.
14. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 6.
15. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 7.
16. A method of inhibiting dental calculus comprising applying to dental surfaces an effective inhibiting amount of a composition as defined in claim 8.
This is a division of application Ser. No. 07/312,532 filed 3/20/86, now U.S. Pat. No. 4,806,877, which was a continuation in part of application Ser. No. 06/775,851 filed 9/13/85, now U.S. Pat. No. 4,627,977.
The prior art indicates that soluble pyrophosphate may be utilized to reduce calculus formation. For example, U.S. Pat. No. 4,515,772 issued May 7, 1985 to Parran et al. refers to several prior art references disclosing oral compositions containing soluble pyrophosphate salts, including an article by Draus et al., Arch. Oral. Biol., 15, pp 893-896, (1970), which discloses the in vitro effectiveness of such salts against calculus. The article refers to possible inhibition of pyrophosphate by pyrophosphatase enzyme.
It is known that saliva contains acid phosphatase, alkaline phosphatase and pyrophosphatase enzymes. It is considered that any one of the three enzymes may adversely affect pyrophosphates as an inhibitor of HAP formation and calculus. It is accordingly apparent that an anticalculus pyrophosphate dentifrice composition, should inhibit, reduce or nullify the destructive activity of all three salivary enzymes
The compositions of the aforementioned Parran et al patent are limited to a pH of 6.0 to 10.0 and comprise a fluoride and soluble dialkali metal pyrophosphates alone or admixed with tetraalkali metal pyrophosphates, but no more than 4.0% K.sub.4 P.sub.2 O.sub.7 (tetrapotassium pyrophosphate) any disclosure or even mention of effectiveness of the patented fluoride-pyrophosphate composition in vivo or saliva.
Yet a further object of this invention is the provision of an improved method for inhibiting the formation of calculus. Other objects and advantages will appear as the description proceeds. Earlier in the development of this invention, it was found that dentifrice compositions containing only tetrasodium pyrophosphate as anticalculus agent were gritty, and that the solid gritty particles were composed of undissolved Na.sub.4 P.sub.2 O.sub.7.
B, an amount of a fluoride ion source sufficient to supply 25 ppm. to 5,000 ppm. of fluoride ions, and
Synthetic anionic polymeric polycarboxylates and their complexes with various cationic germicides, zinc and magnesium have been previously disclosed as anticalculus agents per se in, for example U.S. Pat. No. 3,429,963 to Shedlovsky and instant assignee, U.S. Pat. No. 4,152,420 to Gaffar and instant assignee, U.S. Pat. No. 3,956,480 to Dichter et al. and instant assignee, U.S. Pat. No. 4,138,477 to Gaffar and instant assignee, and U.S. Pat. No. 4,183,914 to Gaffar et al. None of these patents however nor any other known prior art, discloses use of such polycarboxylates alone for inhibiting salivary hydrolysis of pyrophosphate anticalculus agents, much less in combination with a compound providing a source of fluoride ion. It is to be understood that the synthetic anionic polymeric polycarboxylates per se disclosed in these patents are operative in the compositions and methods of this invention and such disclosures are to that extent incorporated herein by reference thereto.
Also useful herein are carboxyvinyl polymers, disclosed as toothpaste components in U.S. Pat. No. 3,980,767 issued Sep. 14, 1976 to Choun et al, U.S. Pat. No. 3,935,306 issued Jan. 27, 1976 to Roberts et al, U.S. Pat. No. 3,919,409 issued Nov. 11, 1975 to Perla et al, U.S. Pat. No. 3,911,904 issued Oct. 7, 1975 to Harrison, and U.S. Pat. No. 3,711,604 issued Jan. 16, 1973 to Colodney et al. They are commercialcially available for example under the trademarks Carbopol 934, 940 and 941 of B. F. Goodrich, these products consisting essentially of a colloidally water-soluble polymer of polyacrylic acid crosslinked with from about 0.75% to about 2.0% of polyallyl sucrose or polyallyl pentaerythritol as cross-linking agent.
In certain desirable forms of this invention, the dentifrice composition may be substantially solid or pasty in character, such as toothpowder, a dental tablet, a toothpaste (cream), or a dental gel. The vehicle of such solid or pasty dentifrice preparations typically contains an orally or dentally acceptable polishing material for use in conjunction with a brushing of the teeth. Examples of such polishing materials are water-insoluble sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated calcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium phosphate, calcium carbonate, aluminum silicate, zirconium silicate, silica, bentonite, and mixtures thereof. Other suitable polishing materials include the particulate thermosetting resins described in U.S. Pat. No. 4,070,510 of Dec. 15, 1962 such as melamine-, phenolic-, and urea-formaldehydes, and cross-linked polyepoxides and polyesters. Preferred polishing materials include crystalline silica having particle sizes of up to about 5 microns, a mean particle size of up to about 1.1 microns, and a surface area of up to about 50,000 cm..sup.2/ gm., silica gel or colloidal silica, and complex amorphous alkali metal alumino-silicate.
EXAMPLE A Effect of Salivary Enzymes on Inhibition of HAP Formation by TSPP The in vitro formation of HAP is measured titrimetrically via a pH stat procedure. Stock solutions of 0.1M CaCl.sub.2 and 0.1M NaH.sub.2 PO.sub.4 are prepared fresh in carbonate-free deionized distilled water. To 23 ml CO.sub.2 -free deionized distilled 1.0 ml. of the stock phosphate solution and 1.0 ml. of an aqueous solution of 1 agent being tested are added followed by 1.0 ml. of the stock calcium chloride solution which initiates the reaction. The reaction is conducted at pH 7.4 under a nitrogen atmosphere. Consumption of 0.1N NaOH is recorded automatically from which the time required for crystal formation is determined. Table A shows the results of this procedure.
Table A shows that in water TSPP significantly delays HAP formation. However, the effectiveness of this agent is drastically reduced when incubated with saliva as evidenced by the shorter delay time. This reduction in efficacy is due to the enzymatic hydrolysis of P-O-P bonds. Incubation of this agent with pyrophosphatase and alkaline phosphatase drastically reduces the delay period and indicates the susceptibility of the P-O-P bond to hydrolysis by phosphatases. Substantially the same results are obtained using tetrapotassium pyrophosphate (TKPP) instead of TSPP, both having the same effective P-O-P bond-containing pyrophsophate ion.
TABLE B______________________________________    Percent Orthophosphate    Released in 90 min.Anticalculus         With     Percent RelativeAgent    Control     Inhibitors                         Protection______________________________________TSPP     98          58       41______________________________________
______________________________________            Parts by Weight            Example 1                     Example 2______________________________________Part 1TSPP               1.500      1.500TKPP               4.500      4.500Sorbitol (70% Aqueous Solution)              22.507     22.500Part 2Polyethylene Glycol 600              5.000      5.000Glycerine          10.750 750 15.000IOTA Carrageenan Gum              0.500      0.450Sodium Fluoride    0.243      0.243Sodium Saccharin   0.300      0 300Gantrez S-97       1.000      1.000Titanium Dioxide   0.500      --Deionized Water    31.000     26.607FD &amp; C Blue #1 (1% Solution)              --         0.200Part 3ZEO 49B (SiO.sub.2)              17.000     16.000SYLOID 244 (Synthetic Silica)              3.000      4.500Part 4Sodium Lauryl Sulfate Powder              1.200      1.200Flavor             1.000      1.000______________________________________
The above formulations are prepared as follows: The components of Part 1 are mixed to solution form. Separately, the components of Part 2, except the water, are mixed to form a dispersion in the polyethylene glycol/glycerin humectant, and the water then mixed in. Parts 1 and 2 are then combined, followed by consecutive addition, with suitable mixing, of Parts 3 and 4. These and the following formulations are designed to retain the anti-caries effect of the fluoride component substantially uneffected by the other components, and to produce no significant tooth erosion effects.
EXAMPLE 3 Employing the same procedure as in Example 1 and 2, the following toothpaste formulation is prepared in accordance with this invention.
______________________________________Example 4Lozenge Formulations        Parts by Weight______________________________________Sugar          75-98Cornsyrup       1-20Flavor Oil     0.1-1.0Tablet lubricant          0.1-5TKPP:TSPP-3:1  3.5-8Gantrez S-97   0.05-3NaF            0.01-0.05Water          0.01-0.2______________________________________
______________________________________Example 5Lozenge             Weight             Percent______________________________________Sodium saccharin    0.15Flavor              0.25Color               0.01Emulsifying Agent*  1.00NaF                 0.05Gantrez S-97        0.30TKPP:TSPP-3:1       6.50Sorbitol            QS to 100______________________________________ *PEG (40) Sorbitan Diisostearate
______________________________________Example 6Chewing Gum               Parts______________________________________Gum base              10    to 50Binder                3     to 10Filler                5     to 80(sorbitol, mannitol orcombination thereof)Artificial sweetener  0.1   to 5TKPP:TSPP-3:1         3.5   to 8Gantrez S-97          0.1   to 1.0NaF                   0.1   to 0.05Flavor                0.1   to 5______________________________________
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS2876167 *Nov 22, 1955Mar 3, 1959Colgate Palmolive CoFluoride dentifrice stabilized by a water-soluble acid phosphate compoundUS3227618 *Mar 9, 1964Jan 4, 1966Colgate Palmolive CoDentifrice composition containing sodium monofluorophosphateUS3634585 *Aug 11, 1966Jan 11, 1972Colgate Palmolive CoDentifrice preparationUS3927201 *Jan 23, 1974Dec 16, 1975Colgate Palmolive CoDentifricesUS3927202 *Jan 23, 1974Dec 16, 1975Colgate Palmolive CoDentifricesUS3951826 *Jul 13, 1973Apr 20, 1976Colgate-Palmolive CompanyAll purpose liquid detergentUS4018720 *Jul 14, 1975Apr 19, 1977The Procter & Gamble CompanyLaundry detergent compositions in emulsion/suspensionUS4107067 *Jun 25, 1976Aug 15, 1978The Procter & Gamble CompanyDetergent compositionUS4272509 *Mar 12, 1980Jun 9, 1981J. M. Huber CorporationPrecipitated silicon dioxide cleaning agent and dentifrice compositionUS4298492 *Jun 9, 1980Nov 3, 1981Lever Brothers CompanyBuilt liquid detergent compositionUS4340583 *Sep 23, 1980Jul 20, 1982J. M. Huber CorporationHigh fluoride compatibility dentifrice abrasives and compositionsUS4375421 *Oct 19, 1981Mar 1, 1983Lever Brothers CompanyViscous compositions containing amido betaines and saltsUS4420312 *Sep 23, 1980Dec 13, 1983J. M. Huber CorporationMethod for production of high fluoride compatibility dentifrice abrasives and compositionsUS4421527 *May 23, 1979Dec 20, 1983J. M. Huber CorporationHigh fluoride compatibility dentifrice abrasives and compositionsUS4436637 *Dec 13, 1982Mar 13, 1984Colgate-Palmolive CompanyFabric softening heavy duty liquid detergent containing a mixture of water insoluble soap and clayUS4469605 *Dec 13, 1982Sep 4, 1984Colgate-Palmolive CompanyFabric softening heavy duty liquid detergent and process for manufacture thereofUS4515772 *Mar 19, 1984May 7, 1985The Procter & Gamble CompanyOral compositionsUS4544494 *Apr 12, 1984Oct 1, 1985Fmc CorporationHomogeneous laundry detergent slurries containing amphoteric surface-active agentsUS4590066 *Feb 19, 1985May 20, 1986The Procter & Gamble CompanyOral compositionsUS4597889 *Aug 30, 1984Jul 1, 1986Fmc CorporationHomogeneous laundry detergent slurries containing polymeric acrylic stabilizersUS4619774 *Sep 4, 1984Oct 28, 1986Colgate Palmolive Co.Fabric softening heavy duty liquid detergent and process for manufacture thereofUS4684518 *Mar 12, 1986Aug 4, 1987The Procter & Gamble CompanyOral compositionsUS4772461 *Jun 9, 1987Sep 20, 1988The Procter & Gamble CompanyOral compositionsUS4784788 *Dec 14, 1985Nov 15, 1988Colgate-Palmolive Co.Cleaning paste with soluble abrasiveUS4806340 *Mar 20, 1986Feb 21, 1989Colgate-Palmolive CompanyAnticalculus oral compositionUS4822599 *Aug 26, 1987Apr 18, 1989The Procter & Gamble CompanyOral compositionsUS4836949 *Feb 16, 1988Jun 6, 1989Johnson & Johnson Consumer Products, Inc.Liquid detergent compositions with phosphate ester solubilizersUS4847070 *Oct 8, 1987Jul 11, 1989The Procter & Gamble CompanyAnticalculus compositionsUS4885155 *Feb 8, 1989Dec 5, 1989The Procter & Gamble CompanyAnticalculus compositions using pyrophosphate saltUS4889712 *Mar 18, 1988Dec 26, 1989Colgate-Palmolive CompanyAnticalculus oral compositionUS4894220 *Dec 29, 1988Jan 16, 1990Colgate-Palmolive CompanyAntibacterial antiplaque oral compositionUS4900475 *Oct 13, 1988Feb 13, 1990Colgate-Palmolive Co.Stabilized built liquid detergent composition containing enzymeUS4906456 *Feb 17, 1989Mar 6, 1990Colgate-Palmolive CompanyAnticalculus oral compositionUS4908211 *Jun 9, 1988Mar 13, 1990Paz Armando FChewing gum and ingredients to chemically inhibit formation of plaque and calculusUS4911927 *Nov 14, 1988Mar 27, 1990Hill Ira DMethod and apparatus for adding chemotherapeutic agents to dental flossUS4913895 *Jul 22, 1987Apr 3, 1990Lion CorporationOral compositionUS4925654 *Feb 8, 1989May 15, 1990Colgate-Palmolive CompanyAnticalculus oral compositionUS4931273 *Nov 16, 1989Jun 5, 1990Colgate-Palmolive CompanyAnticalculus oral compositionEP0097476A2 *Jun 14, 1983Jan 4, 1984THE PROCTER &amp; GAMBLE COMPANYOral compositionsEP0236290A1 *Mar 4, 1987Sep 9, 1987Monsanto CompanyAnticalculus dentifricesEP0249398A2 *Jun 4, 1987Dec 16, 1987THE PROCTER &amp; GAMBLE COMPANYOral compositionsEP0251591A1 *Jun 19, 1987Jan 7, 1988Beecham Group PlcOral hygiene compositionEP0291747A1 *Apr 29, 1988Nov 23, 1988Blendax GmbHToothpasteEP0295116A1 *Jun 10, 1988Dec 14, 1988Unilever PlcOral compositionsEP0309414A2 *Aug 26, 1988Mar 29, 1989AVANTGARDE S.p.A.Chewing gum having antitartar activityEP0311412A2 *Oct 7, 1988Apr 12, 1989THE PROCTER &amp; GAMBLE COMPANYAnticalculus compositionsEP0331415A1 *Feb 28, 1989Sep 6, 1989Unilever PlcAnticalculus oral compostionsGB2182244A * Title not availableGB2188548A * Title not availableGB2201593A * Title not available* Cited by examinerNon-Patent CitationsReference1 *Bergman et al. CA 67:120481n (1967).2 *Bergman et al. CA 69:54925y (1968).3 *Bukhalova et al. CA. 77: 169493p (1972).4 *Fabi et al. CA. 108: 22660a (1987).5 *Morgan et al. CA 78: 90781t (1973).6 *White et al. CA. 105: 11843g (1986).7 *White et al. CA. 106: 38215u (1987).* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS5240697 *Oct 17, 1991Aug 31, 1993Colgate-Palmolive CompanyDesensitizing anti-tartar dentifriceUS5255443 *Oct 30, 1992Oct 26, 1993Great Neck Saw Manufacturing, Inc.Post level with detentUS5374417 *Oct 6, 1993Dec 20, 1994Colgate Palmolive CompanyDesensitizing dentifriceUS5376360 *Aug 30, 1993Dec 27, 1994Church & Dwight Co., Inc.Baking soda toothpaste containing soluble pyrophosphate saltsUS5455024 *Jan 26, 1995Oct 3, 1995Church & Dwight Co., Inc.Dentifrices containing zinc oxide particles and sodium bicarbonateUS5851512 *May 30, 1997Dec 22, 1998Ultradent Products, Inc.Dental compositions having a sticky matrix material for treating sensitive teethUS5885556 *Aug 6, 1996Mar 23, 1999The Procter & Gamble CompanyTartar control oral compositionsUS5985249 *Oct 14, 1997Nov 16, 1999Ultradent Products, Inc.Sticky dental compositions for adhering a passive-type dental tray over a person's teethUS6036943 *Oct 14, 1997Mar 14, 2000Ultradent Products, Inc.Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental traysUS6241974 *Apr 22, 1997Jun 5, 2001The Procter & Gamble CompanyDentifrice compositions containing β-phase calcium pyrophosphate an anticalculus agent, and fluorideUS8535730 *Jun 11, 1993Sep 17, 2013Colgate-Palmolive CompanyAnticalculus oral compositionWO1993007851A1 *May 13, 1992Apr 29, 1993Church & Dwight Co IncBuffering system for anticalculus dentifricesWO1995006455A1 *Aug 29, 1994Mar 9, 1995Church & Dwight Co IncBaking soda toothpaste and tooth gel containing soluble pyrophosphate salts* Cited by examinerClassifications U.S. Classification424/52, 424/57International ClassificationA61K8/24, A61K8/39, A61K8/90, A61Q11/00, A61K8/81Cooperative ClassificationA61K8/39, A61K8/8164, A61Q11/00, A61K8/90, A61K8/24European ClassificationA61K8/24, A61K8/90, A61K8/81M, A61Q11/00, A61K8/39Legal EventsDateCodeEventDescriptionJun 17, 2002SULPSurcharge for late paymentYear of fee payment: 11Jun 17, 2002FPAYFee paymentYear of fee payment: 12May 14, 2002REMIMaintenance fee reminder mailedMar 27, 1998FPAYFee paymentYear of fee payment: 8Apr 28, 1994FPAYFee paymentYear of fee payment: 4Aug 11, 1992CCCertificate of correctionRotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google