Source: http://www.google.com/patents/US7892198?dq=5708422
Timestamp: 2016-02-08 23:19:34
Document Index: 47553794

Matched Legal Cases: ['Application No. 01', 'Application No. 01', 'Application No. 01', 'Application No. 01', 'Application No. 01', 'Application No. 01', 'art 2', 'art 2', 'art 2', 'art 2', 'art 2']

Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3036584Jul 18, 1961May 29, 1962Invengineering IncNon-rebreathing valve for gas administrationUS3192106Aug 13, 1962Jun 29, 1965British Oxygen Co LtdGas mixtures containing nitrous oxideUS4127121Sep 17, 1976Nov 28, 1978University Of UtahOxygen and anesthesia delivery and monitoring deviceUS4191952Aug 25, 1978Mar 4, 1980N.A.D., Inc.Low oxygen flow alarm for anesthesia systemsUS4224941Nov 15, 1978Sep 30, 1980Stivala Oscar GHyperbaric treatment apparatusUS4328823May 14, 1980May 11, 1982N.A.D. Inc.Oxygen flow ratio controller for anesthesia apparatusUS4336798Oct 6, 1980Jun 29, 1982Anthony V. BeranMedical corrugated respiratory tubeUS4345612Jun 9, 1980Aug 24, 1982Citizen Watch Company LimitedAnesthetic gas control apparatusUS4442856Aug 18, 1981Apr 17, 1984Puritan-BennettOxygen regulator and alarm system for an anesthesia machineUS4608041Oct 11, 1982Aug 26, 1986Frese NielsenDevice for treatment of wounds in body tissue of patients by exposure to jets of gasUS4611590Nov 28, 1984Sep 16, 1986Dragerwerk AktiengesellschaftArrangement for adding liquid anesthetic to the respiratory gas supplied to a patientUS4770168Dec 16, 1985Sep 13, 1988Tibor RuszElectrically controllable anesthesia vaporizerUS4905685Apr 13, 1988Mar 6, 1990Siemens AktiengesellschaftInhalation anaesthesia equipmentUS4954526Feb 28, 1989Sep 4, 1990The United States Of America As Represented By The Department Of Health And Human ServicesStabilized nitric oxide - primary amine complexes useful as cardiovascular agentsUS5154697Apr 2, 1991Oct 13, 1992Topox, Inc.Collapsible topical hyperbaric apparatusUS5155137Sep 20, 1990Oct 13, 1992The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesComplexes of nitric oxide with polyaminesUS5159924Oct 3, 1990Nov 3, 1992Cegielski Michael JMethod and apparatus for selectively mixing gasesUS5197462Feb 10, 1992Mar 30, 1993Dragerwerk AktiengesellschaftAnesthetic metering deviceUS5370849Oct 29, 1992Dec 6, 1994The Regents Of The University Of CaliforniaMetal chelate process to remove pollutants from fluidsUS5396882Mar 11, 1992Mar 14, 1995The General Hospital CorporationGeneration of nitric oxide from air for medical usesUS5423313Mar 9, 1982Jun 13, 1995Siemens-Elema AbRespirator intended for connection to human or animal airwaysUS5427797Apr 6, 1993Jun 27, 1995Brigham And Women's HospitalSystemic effects of nitric oxide inhalationUS5485827Feb 10, 1995Jan 23, 1996The General Hospital CorporationMethods and devices for treating plumonary vasoconstriction and asthmaUS5514204 *Jul 7, 1994May 7, 1996The Boc Group, Inc.Process for the purification of nitric oxideUS5519020Oct 28, 1994May 21, 1996The University Of AkronPolymeric wound healing acceleratorsUS5531218Apr 12, 1994Jul 2, 1996Messer Griesheim GmbhApparatus for the monitored metering of no into patients' respiratory airUS5536241Mar 24, 1993Jul 16, 1996The General Hospital CorporationMethods and devices for relaxing smooth muscle contractionsUS5558083Nov 22, 1993Sep 24, 1996Ohmeda Inc.Nitric oxide delivery systemUS5570683Apr 1, 1994Nov 5, 1996The General Hospital CorporationMethods and devices for treating pulmonary vasoconstriction and asthmaUS5615669Dec 11, 1995Apr 1, 1997Siemens Elema AbGas mixture and device for delivering the gas mixture to the lungs of a respiratory subjectUS5632981Nov 22, 1994May 27, 1997The United States Of America As Represented By The Department Of Health And Human ServicesBiopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using sameUS5648101Nov 14, 1994Jul 15, 1997Tawashi; RashadDrug delivery of nitric oxideUS5650442Oct 7, 1994Jul 22, 1997The United States Of America As Represented By The Department Of Health And Human ServicesUse of nitric oxide releasing compounds as hypoxic cell radiation sensitizersUS5651358May 11, 1995Jul 29, 1997L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges ClaudeNitric oxide ventilation arrangement and methodUS5679963Dec 5, 1995Oct 21, 1997Sandia CorporationSemiconductor tunnel junction with enhancement layerUS5688236May 17, 1996Nov 18, 1997Stephen's Medical, Inc.Topical hyperbaric device for treating skin disordersUS5692497May 16, 1996Dec 2, 1997Children's Medical Center CorporationMicroprocessor-controlled ventilator system and methodsUS5700830Nov 22, 1994Dec 23, 1997The United States Of America As Represented By The Department Of Health And Human ServicesUse of nitric oxide-releasing agents for reducing metastasis riskUS5713349Jun 2, 1994Feb 3, 1998Keaney; NiallInhalation therapyUS5722392May 19, 1995Mar 3, 1998University Of FloridaBreathable gas mixing devices, breathing systems and methodsUS5725492Mar 4, 1996Mar 10, 1998Cormedics CorpExtracorporeal circulation apparatus and methodUS5732693Dec 13, 1996Mar 31, 1998Ohmeda Inc.Pause control of nitric oxide therapyUS5765548May 7, 1996Jun 16, 1998Perry; Bryan J.Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equineUS5789447Sep 12, 1995Aug 4, 1998The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide releasing compounds as protective agents in ischemia reperfusion injuryUS5810795May 13, 1996Sep 22, 1998Westwood; Joseph R.Hyperbaric device with secondary pressure zoneUS5814666Apr 24, 1995Sep 29, 1998The United States As Represented By The Department Of Health And Human ServicesEncapsulated and non-encapsulated nitric oxide generators used as antimicrobial agentsUS5814667Mar 11, 1997Sep 29, 1998United States Of America As Represented By The Department Of Health And Human ServicesUse of nitric oxide-releasing compounds as hypoxic cell radiation sensitizersUS5823180Apr 3, 1995Oct 20, 1998The General Hospital CorporationMethods for treating pulmonary vasoconstriction and asthmaUS5834030Jun 7, 1995Nov 10, 1998Vasogen, Inc.Method of increasing the concentration of nitric oxide in human bloodUS5837736Mar 11, 1997Nov 17, 1998The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agentsUS5839433Oct 11, 1994Nov 24, 1998Higenbottam; Timothy WilliamNitric oxide treatmentUS5840759Mar 11, 1997Nov 24, 1998The United States Of America As Represented By The Department Of Health And Human ServicesUse of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agentsUS5845633Nov 22, 1996Dec 8, 1998Siemens Elema A.B.Dosing device for adding a controlled amount of a gas to a fluidUS5873359Dec 9, 1994Feb 23, 1999The General Hospital CorporationMethods and devices for treating pulmonary vasoconstriction and asthmaUS5885621Apr 4, 1997Mar 23, 1999The General Hospital CorporationTreatment of a hemoglobinopathyUS5904938Jan 17, 1997May 18, 1999The General Hospital CorporationTreatment of vascular thrombosis and restenosis with inhaled nitric oxideUS5918596Apr 22, 1997Jul 6, 1999Instrumentarium Corp.Special gas dose delivery apparatus for respiration equipmentUS5957880Feb 23, 1998Sep 28, 1999Cormedics Corp.Extracorporeal circulation apparatus and methodUS6000403Jul 30, 1996Dec 14, 1999Cantwell; Evelyna DysonOxygen bandageUS6060020Apr 9, 1998May 9, 2000S.P.M. Recovery Technologies LtdMethod and apparatus for treating objects with ozoneUS6063407Feb 16, 1995May 16, 2000The General Hospital CorporationTreatment of vascular thrombosis and restenosis with inhaled nitric oxideUS6067983Sep 19, 1997May 30, 2000Sensormedics CorporationMethod and apparatus for controlled flow sampling from the airwayUS6071254Mar 18, 1999Jun 6, 2000Augustine Medical, Inc.Near hyperthermic heater wound coveringUS6073627Jul 30, 1998Jun 13, 2000Medizone International, Inc.Apparatus for the application of ozone/oxygen for the treatment of external pathogenic conditionsUS6083209Sep 18, 1998Jul 4, 2000Marasco, Jr.; Patrick VTissue debriding apparatusUS6089229May 26, 1998Jul 18, 2000Datex-Ohmeda, Inc.High concentration no pulse delivery deviceUS6103273Jun 21, 1994Aug 15, 2000Antoun; JacquesPharmaceutical composition comprising starch, a compound comprising boron, a compound comprising zinc, and water, and a method of using same to encourage hair growthUS6103275Jun 10, 1998Aug 15, 2000Nitric Oxide SolutionsSystems and methods for topical treatment with nitric oxideUS6109260Feb 18, 1998Aug 29, 2000Datex-Ohmeda, Inc.Nitric oxide administration device with timed pulseUS6110895Dec 15, 1997Aug 29, 2000University Of Southern CaliforniaMethod of promoting healing in skin graftsUS6125846May 16, 1997Oct 3, 2000Datex-Ohmeda, Inc.Purge system for nitric oxide administration apparatusUS6131572May 20, 1998Oct 17, 2000Instrumentarium OyMedical dosing device having dosing chamber with a pressure sensorUS6142147Apr 21, 1998Nov 7, 2000The General Hospital CorporationNasal delivery system for inhaled nitric oxideUS6158434Feb 27, 1996Dec 12, 2000Henk W. KosterVentilatory system with additional gas administratorUS6160021Feb 3, 1998Dec 12, 2000The General Hospital CorporationMethod for treating epidermal or dermal conditionsUS6164276May 26, 1998Dec 26, 2000Datex-Ohmeda, Inc.Accurate dose nitric oxide pulse delivery device with monitoring and alarmsUS6190704 *Sep 23, 1994Feb 20, 2001New York Society For The Ruptured And Crippled Maintaining The Hospital For Special SurgeryRegulation of wound healing by nitric oxideUS6200558Apr 22, 1997Mar 13, 2001The United States Of America As Represented By The Department Of Health And Human ServicesBiopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using sameUS6232336Jul 1, 1998May 15, 2001The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making sameUS6270779May 10, 2000Aug 7, 2001United States Of AmericaNitric oxide-releasing metallic medical devicesUS6358536Oct 2, 1998Mar 19, 2002Thomas Jefferson UniversityNitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammalUS6379660Sep 20, 2000Apr 30, 2002The United States Of America As Represented By The Secretary Of The Department Of Health And Human ServicesNitric oxide-releasing 1-[(2-carboxylato)pyrrolidin-1-yl] diazen-1-ium-1,2-diolates and composition comprising sameUS6432077Dec 26, 2000Aug 13, 2002Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxideUS6472390Nov 13, 2001Oct 29, 2002Duke UniversityUse of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressureUS6494314May 2, 2000Dec 17, 2002Johns Hopkins UniversityPre-filled package containing unit dose of medical gas and method of making sameUS6511991Apr 3, 2001Jan 28, 2003The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making sameUS6555058Dec 22, 2000Apr 29, 2003Asahi Medical Co., Ltd.Apparatus for artificial kidney, quality evaluating device for dialyzing fluid and dialyzing means using the same, and fluid circuitUS6571790Jul 19, 2001Jun 3, 2003Robert E. WeinsteinMethod and device for organizing and coordinating the combined use of liquid medications for continuous nebulization for the treatment of respiratory disordersUS6581599Nov 24, 1999Jun 24, 2003Sensormedics CorporationMethod and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patientsUS6601580Jun 28, 2000Aug 5, 2003The General Hospital CorporationEnhancing therapeutic effectiveness of nitric oxide inhalationUS6715485Mar 3, 2000Apr 6, 2004Optinose AsNasal delivery deviceUS6747062Feb 28, 2003Jun 8, 2004New York Society For The Ruptured And Crippled Maintaining The Hospital For Special SurgeryRegulation of wound healing by nitric oxideUS6750254Jan 22, 2003Jun 15, 2004The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing amidine—and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making sameUS6758214Jan 26, 2001Jul 6, 2004Cyterra CorporationSimple nitric oxide generator for ambulatory and/or bedside inhaled no treatmentUS6780849Dec 21, 2000Aug 24, 2004Scimed Life Systems, Inc.Lipid-based nitric oxide donorsUS6786217Jan 21, 2003Sep 7, 2004Sensormedics CorporationMethod and apparatus of delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patientsUS6793644 *Jun 14, 2002Sep 21, 2004Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxideUS6796966Feb 5, 2002Sep 28, 2004Jeffrey E. ThomasApparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammalUS6811965Mar 2, 2001Nov 2, 2004Yoram VodovotzKidney perfusion solution containing nitric oxide donor, inhibitor of NOS2, glutathione, gluconate and methods of useUS6867194Aug 9, 2001Mar 15, 2005Wayne State UniversityEnzyme activated nitric oxide donorsUS6887485May 25, 2001May 3, 2005Medtronic Vascular, Inc.Nitric oxide-releasing metallic medical devicesUS6911478Mar 23, 2004Jun 28, 2005The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making sameUS6920876Dec 10, 2002Jul 26, 2005Pulmonox Technologies CorporationDevice for administration of nitric oxide to horses spontaneously breathingUS6938357Sep 9, 2003Sep 6, 2005Carter Day International, Inc.Forced air circulation for centrifugal pellet dryerUS6949530Jul 18, 2002Sep 27, 2005The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making sameUS7048951May 24, 2000May 23, 2006Nioxx, LlcSystems and methods for topical treatment with nitric oxideUS7105502Nov 6, 2003Sep 12, 2006The United States Of America As Represented By The Department Of Health And Human ServicesNitric oxide-releasing imidate and thioimidate diazeniumdiolatesUS7118767Jul 26, 2002Oct 10, 2006Jakwang Co., Ltd.Pharmaceutical composition for increasing the production of nitric oxide and IFN-γ, and process for preparation thereofUS7122018Dec 23, 2004Oct 17, 2006Sensormedics CorporationDevice and method for treatment of wounds with nitric oxideUS7199154Jul 24, 2003Apr 3, 2007Merck Frosst CompanyNitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitorsUS20020069877Dec 13, 2000Jun 13, 2002Villareal Daniel C.Ventilation transport deviceUS20020082566Dec 26, 2000Jun 27, 2002Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxideUS20020119115Jan 8, 2002Aug 29, 2002Office Of Technology Transfer, National Institutes Of HealthNitric oxide-releasing medical devicesUS20020138051Mar 26, 2001Sep 26, 2002Hole Douglas R.System and method for the prevention and treatment of animal wound infections using nitric oxideUS20020155164 *Apr 18, 2001Oct 24, 2002Curtis FigleySystem and method for the prevention of infections in human patients using nitric oxideUS20020156416Jun 14, 2002Oct 24, 2002Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxideUS20020169202Jan 28, 2002Nov 14, 2002Ajinomoto Co. IncPromoter for production of nitric oxide or nitric oxide synthase, and cosmetic or pharmaceutical composition comprising the sameUS20030039697Mar 20, 2001Feb 27, 2003Yi-Ju ZhaoMatrices containing nitric oxide donors and reducing agents and their useUS20030150457Dec 10, 2002Aug 14, 2003Christopher MillerDevice for administration of nitric oxide to horses spontaneously breathingUS20030165578Feb 28, 2003Sep 4, 2003New York Society For The Ruptured And Crippled Maintaining The Hospital For Special SurgeryRegulation of wound healing by nitric oxideUS20030203915Apr 7, 2003Oct 30, 2003Xinqin FangNitric oxide donors, compositions and methods of use related applicationsUS20030215528Mar 6, 2003Nov 20, 2003Queens University At KingstonFormulations and methods of using nitric oxide mimetics against a malignant cell phenotypeUS20030228564Feb 10, 2003Dec 11, 2003Edrich Richard AlanNitric oxide in a pathogen inactivation processUS20040009238Jul 8, 2003Jan 15, 2004Chris MillerExogenenous nitric oxide gas (gNO) therapy in wound healingUS20040043026May 13, 2003Mar 4, 2004Tai-Lan TuanTreatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesionsUS20040081580Sep 9, 2003Apr 29, 2004Doug HoleUse of nitric oxide and a device in the therapeutic management of pathogens in mammalsUS20040112378Feb 26, 2002Jun 17, 2004Djupesland Per GisleNasal devicesUS20040131703Jun 20, 2003Jul 8, 2004Bach Fritz H.Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradationUS20040163647Oct 24, 2003Aug 26, 2004Pulmonox Technologies CorporationSystem and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patientUS20040180863Mar 23, 2004Sep 16, 2004Govt. Of The Usa, Rep. By The Secretary, Dept. Of Health & Human Servs., Office Of Tech. TransferNovel, nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making sameUS20040259840Jul 6, 2004Dec 23, 2004Herrmann Robert A.Lipid-based nitric oxide donorsUS20050016427Aug 20, 2004Jan 27, 2005Memory Russell J.Internal tank augers for air seeder hoppersUS20050079148Jul 17, 2003Apr 14, 2005Fitzhugh Anthony L.Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and useUS20050137521Sep 17, 2004Jun 23, 2005Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxideUS20050142217Oct 25, 2001Jun 30, 2005Adams Michael A.Formulations and methods of using nitric oxide mimetics against a malignant cell phenotypeUS20050148566Nov 5, 2004Jul 7, 2005The Government Of The Usa, As Rep. By The Secretary, Dept. Of Health & Human ServicesPolydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using sameUS20050171066Mar 21, 2003Aug 4, 2005Paul ShamiVivo use of glutathione s-transferase activated nitric oxide donorsUS20050191372Dec 23, 2004Sep 1, 2005Alex StenzlerDevice and method for treatment of wounds with nitric oxideUS20050217668Mar 18, 2005Oct 6, 2005Pulmonox Technologies CorporationSystem and elements for managing therapeutic gas administration to a spontaneously breathing non-ventilated patientUS20050217679Apr 14, 2005Oct 6, 2005Christopher MillerNitric oxide decontamination of the upper respiratory tractUS20050251117May 7, 2004Nov 10, 2005Anderson Robert SApparatus and method for treating biological external tissueUS20050265958May 16, 2005Dec 1, 2005West Jennifer LNitric oxide releasing compositions and associated methodsUS20050288260Aug 19, 2005Dec 29, 2005Government Of The United States Of America, Represented By The Secretary, Department Of HealthNovel nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making sameUS20060008529Jul 12, 2004Jan 12, 2006Meyerhoff Mark EUse of additive sites to control nitric oxide release from nitric oxide donors contained within polymersUS20060068031Sep 29, 2004Mar 30, 2006Chris MillerUse of exogenous gasoues nitric oxide in the treatment and disinfection of biofilmsUS20060147553Aug 23, 2005Jul 6, 2006Miller Christopher CMethod and apparatus for treatment of respiratory infections by nitric oxide inhalationUS20070065473Aug 1, 2006Mar 22, 2007Miller Christopher CNitric oxide gas (gO) as a cosmetic and wound healing agentUS20070086954Nov 1, 2006Apr 19, 2007Miller Christopher CMethod and apparatus for treatment of respiratory infections by nitric oxide inhalationUS20070088316Jul 13, 2006Apr 19, 2007Alex StenzlerDevice and method for treatment of wounds with nitric oxideUS20070104653Nov 10, 2006May 10, 2007Miller Christopher CUse of inhaled gaseous nitric oxide as a mucolytic agent or expectorantEP0640356A1Jun 1, 1994Mar 1, 1995Siemens Elema ABDevice for supplying breathing gasEP0640357A1Jun 1, 1994Mar 1, 1995Siemens Elema ABGas mixture and device for delivering the gas mixture to the lungs of a living beingEP0659445A1Nov 18, 1994Jun 28, 1995Ohmeda Inc.Nitric oxide delivery systemEP0659445B1Nov 18, 1994May 10, 2000Datex-Ohmeda, Inc.Nitric oxide delivery systemEP1243278A2Feb 8, 1993Sep 25, 2002Vasogen, Inc.Method of increasing the concentration of nitric oxide in bloodFR2656218A1 Title not availableWO2001065935A1Mar 2, 2001Sep 13, 2001Frederick A GageKidney perfusion solution containing nitric oxide donorWO2003066109A1Feb 10, 2003Aug 14, 2003Gambro IncNitric oxide in a pathogen inactivation processWO2005060603A3Dec 10, 2004Dec 1, 2005Garvey David SNitric oxide releasing pyruvate compounds, compositions and methods of useWO2005110052A3May 11, 2005Mar 2, 2006Hole DougThe use of inhaled gaseous nitric oxide as a mucolytic agent or expectorantWO2005110441A2May 11, 2005Nov 24, 2005Sensormedics Corp Viasys HealtIntermittent dosing of nitric oxide gas* Cited by examinerNon-Patent CitationsReference1"Amendment and Argument," Aug. 24, 2007, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.2"Amendment and Argument," Jun. 26, 2008, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.3"Amendment," Dec. 10, 2008, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.4"Communication pursuant to Article 96(2) EPC," Aug. 29, 2007, European Application No. 01 992 077.1.5"Communication pursuant to Article 96(2) EPC," Dec. 9, 2008, European Application No. 01 992 077.1.6"Communication pursuant to Article 96(2) EPC," Sep. 14, 2006, European Application No. 01 992 077.1.7"Decision for Rejection," Aug. 12, 2008, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.8"Demand for a Trial," Nov. 12, 2008, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.9"In response to the official Communication dated Aug. 29, 200[7]," Mar. 5, 2008, European Application No. 01 992 077.1.10"In response to the official Communication dated Dec. 9, 2008," Jun. 16, 2009, European Application No. 01 992 077.1.11"Notification of Reason for Rejection," Dec. 21, 2007, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.12"Notification of Reason for Rejection," Feb. 22, 2007, Japanese App. No. 2002-552501 and English-language translation provided by the law firm Yuasa and Hara.13"Reverting to the Communication of Sep. 14, 2006," Mar. 13, 2007, European Application No. 01 992 077.1.14Abstract for DE 003713396 A1, Nov. 1998, Zeuch et al.15Archer, S. L., "Comparison of the Hemodynamic Effects of Nitric Oxide and Endothelium-Dependent Vasodilators in Intact Lungs," Journal of Applied Physiology, vol. 68, No. 2, pp. 735-747 (Feb. 1990).16Assreuy, J. et al., "Feedback Inhibition of Nitric Oxide Synthase Activity by Nitric Oxide," British Journal of Pharmacology, vol. 108, pp. 883-837 (Mar. 1993).17Barash, P., et al., "Anesthesiology," The Journal of the American Medical Association, vol. 268, No. 3, pp. 335-337 (Jul. 1992).18Bass, H. et al., "Regional structure and function in brochiectasis," Am. Rev. Respir. Dis. 97:598-609 (1968).19Bauer, J. A., et al., Evaluation of Linear Polyethylenei-mine/Nitric Oxide Adduct on Wound Repair: Therapy Versus Toxicity, The Wound Healing Society, pp. 569-577 (1998).20Bigatello, L. M., "Inhaled Nitric Oxide is a Selective Pulmonary Vasodilator in Septic Patients with Severe ARDS," Abstract, American Review of Respiratory Disease, Suppl., vol. 145, No. 4, Par 2, p. A185 (Apr. 1992).21Bigatello, L. M., "Inhaled Nitric Oxide is a Selective Pulmonary Vasodilator in Septic Patients with Severe ARDS," Abstract, American Review of Respiratory Disease, Suppl., vol. 145, No. 4, Part 2, p. A185 (Apr. 1992).22Blomqvist, H., et al., "Enhanced Pneumonia Resolution by Inhalation of Nitric Oxide?" Acta Anaesthesiol Scand, vol. 37, pp. 110-114 (1993).23Body, S. C., M.D., et al., "Nitric Oxide: Delivery, Measurement, and Clinical Application," Journal of Cardiothoracic and Vascular Anesthesia, vol. 9, No. 6, pp. 748-763 (Dec. 1995).24Borland, C. D. R., et al., "A Simultaneous Single Breath Measurement of Pulmonary Diffusing Capacity with Nitric Oxide and Carbon Monoxide," The European Respiratory Journal, vol. 2, No. 1, pp. 56-63 (Jan. 1989).25Borland, C., "The Fate of Inhaled Nitric Oxide," Clinical Science, Abstract No. 104, p. 37P (1983).26Buga, G. M., et al., "Endothelium-Derived Nitric Oxide Relaxes Nonvascular Smooth Muscle," European Journal of Pharmacology, vol. 161, No. 1, pp. 61-72, (Feb. 1989).27Buga, G. M., et al., "Negative Feedback Regulation of Endothelial Cell Function by Nitric Oxide," Circulation Research, Journal of the American-Heart Association, 73:808-812 (1993).28Bult, H., et al., "Chronic Exposure to Exogenous Nitric Oxide May Suppress its Endogenous Release and Efficacy," Journal of Cardiovascular Pharmacology, vol. 17, Suppl. 3, pp. S79-S82 (1991).29Butt, A. Y., et al., "New Therapies for Primary Pulmonary Hypertension," Chest, vol. 105, No. 2, pp. 21S-25S (Feb. 1994).30Canetti, G., "Present aspects of bacterial resistance in tuberculosis," Am. Rev. Respir. Dis. 92:687-703 (1965).31Chan, J. et al., "Effects of Nitric Oxide Synthase Inhibitors on Murine Infection with Mycobacterium Tuberculosis," Infection and Immunity, vol. 63, No. 2., pp. 736-740 (Feb. 1995).32Chan, J. et al., "Killing of Virulent Mycobacterium Tuberculosis by Reactive Nitrogen Intermediates Produced by Activated Murine Macophages," J. Exp. Med. 175:1111-1122 (Apr. 1992).33Channick, R. N., M.D., et al., "Pulsed Delivery of Inhaled Nitric Oxide to Patients with Primary Pulmonary Hypertension," Chest, The Cardiopulmonary and Critical Care Journal, vol. 109, No. 6, pp. 1545-1549 (Jun. 1996).34Contractor, A. M., et al., "Development and Evaluation of an Inhalation Aerosol of Nitroglycerin," Journal of Pharmaceutical Sciences, vol. 63, No. 6, pp. 907-911 (Jun. 1974).35Counter-Defendant's First Amended Responses to Counterclaimant's Second Set of Interrogatories Relating to Counterclaims (Nos. 19-38) (Oct. 2003).36Cremona, g., et al., "Endothelium-derived Relaxing Factor and the Pulmonary Circulation," Lung, vol. 169, pp. 185-202 (1991).37Cuthbertson, B. H., et al., "Inhaled Nitric Oxide," The Lancet, vol. 348, No. 9039, pp. 1447-1448 (Nov. 1996).38DeGroote, M. A. et al., "NO Inhibitions: Antimicrobial Properties of Nitric Oxide," Clinical Infectious Diseases, vol. 21, Suppl. 2, pp. S162-S165 (Oct. 1995).39Demling, R. H., et al., "The Pulmonary and Systemic Response to Recurrent Endotoxemia in the Adult Sheep," Surgery, vol. 100, No. 5, pp. 876-883 (Nov. 1986).40Denis, M., "Interferon-Gamma-treated Murine Macrophages Inhibit Growth of Tubercle Bacilli via the Generation of Reactive Nitrogen Intermediates," Cellular Immunology, vol. 132, No. 1, pp. 150-157 (Jan. 1991).41Denis, M., "Interferon—Gamma-treated Murine Macrophages Inhibit Growth of Tubercle Bacilli via the Generation of Reactive Nitrogen Intermediates," Cellular Immunology, vol. 132, No. 1, pp. 150-157 (Jan. 1991).42Dinh-Xuan, A. T., et al., "Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease," The New England Journal of Medicine, vol. 324, No. 22, pp. 1539-1547 (May 1991).43Dinh-Xuan, A. T., et al., "Non-Prostanoid Endothelium-Derived Vasoactive Factors," The Journal of International Medical Research, vol. 17, pp. 305-315 (1989).44Dinh-Xuan, A. T., et al., "Primary Pulmonary Hypertension: Diagnosis, Medical and Surgical Treatment," vol. 84, pp. 189-197 (1990).45Dong, Z. et al., "Inverse Correlation Between Expression of Inducible Nitric Oxide Synthase Activity and Production of Metastasis in K-1735 Murine Melanoma Cells," Cancer Research, vol. 54, pp. 789-793 (Feb. 1, 1994).46Dupuy, P. M., et al., "Bronchial Effects of Nitric Oxide," Nitric Oxide and the Lung, vol. 98, Chapter 15, pp. 285-311 (1997).47Dupuy, P. M., et al., "Bronchodilator Action of Inhaled Nitric Oxide in Guinea Pigs," J. Clin. Invest., vol. 90, pp. 421-428 (Aug. 1992).48Falke, K., et al., "Inhaled Nitric Oxide Selectively Reduces Pulmonary Hypertension in Severe ARDS and Improves Gas Exchange as well as right Heart Ejection fraction-A Case Report," Abstract 248, Am. Rev. Respir. Dis., vol. 143 (1991).49Falke, K., et al., "Inhaled Nitric Oxide Selectively Reduces Pulmonary Hypertension in Severe ARDS and Improves Gas Exchange as well as right Heart Ejection fraction—A Case Report," Abstract 248, Am. Rev. Respir. Dis., vol. 143 (1991).50Foubert, L., "Safety Guidelines for Use of Nitric Oxide," The Lancet, vol. 339, No. 8809, pp. 1615-1616 (Jun. 1992).51Foubert, L., et al., "Nitric Oxide in Pulmonary Hypertension: Therapeutic Considerations," Journal of Cardiothoracic and Vascular Anesthesia, vol. 8, No. 3, Suppl. 2, p. 41 (Jun. 1994).52Francoe, M, RRT, et al., "Inhaled Nitric Oxide: Technical Aspects of Administration and Monitoring," Critical Care Medicine, vol. 26, No. 4, pp. 782-796 (Apr. 1998).53Frank, S. et al., "Nitric Oxide Drives Skin Repair: Novel Functions Of An Established Mediator," Kidney International, vol. 61, pp. 882-888 (2002).54Fratacci, M. D., "Inhaled Nitric Oxide-A Selective Pulmonary Vasodilator of Heparin-Protamine Vasoconstriction in Sheep," Anesthesiology, vol. 75, pp. 990-999 (1991).55Fratacci, M. D., "Inhaled Nitric Oxide—A Selective Pulmonary Vasodilator of Heparin-Protamine Vasoconstriction in Sheep," Anesthesiology, vol. 75, pp. 990-999 (1991).56Frostell, C. et al., "Inhaled Nitric Oxide, A Selective Pulmonary Vasodilator Reversing Hypoxic Pulmonary Vasoconstriction," Circulation Journal of the American Heart Association, vol. 83, pp. 2083-2047 (1991).57Frostell, C., et al., "Inhaled Nitric Oxide Dilates Human Hypoxic Pulmonary Vasoconstriction Without Causing Systemic Vasodilation," Anesthesiology, The Journal of The American Society of Anesthesiologists, Inc., vol. 75, No. 3A, Abstract A989 (Sep. 1991).58Frostell, C., et al., "Inhaled Nitric Oxide-A Selective Pulmonary Vasodilator Reversing Hypoxic Pulmonary Vasoconstriction," Circulation, vol. 83, No. 6 (Jun. 1991).59Frostell, C., et al., "Inhaled Nitric Oxide—A Selective Pulmonary Vasodilator Reversing Hypoxic Pulmonary Vasoconstriction," Circulation, vol. 83, No. 6 (Jun. 1991).60Garg, U.C., et al., "Nitric Oxide-generating Vasodilators and 8-Bromo-Cyclic Guanosine Monophosphate Inhibit Mitogensis and Proliferation of Cultured Rat Vascular Smooth Muscle Cells," The Journal of Clinical Investigation, vol. 83, No. 5, pp. 1774-1777 (May.61Gerlach, H., et al., "Low Levels of Inhaled Nitric Oxide in Acute Lung Injury," Nitric Oxide and the Lung, vol. 98, Chapter 14, pp. 271-283 (1997).62Ghaffair, A. et al., "A Direct Nitric Oxide Gas Delivery System for Bacterial and Mammalian Cell Cultures," Nitric Oxide Biology and Chemistry, vol. 12, pp. 129-140 (2005).63Girard, C., et al., "Inhaled Nitric Oxide (NO) in Pulmonary Hypertension Following Mitral Valve Replacement," Anesthesiology, The Journal of The American Society of Anesthesiologists, Inc., vol. 75, No. 3A, Abstract A983 (Sep. 1991).64Girard, C., et al., "Inhaled Nitric Oxide After Mitral Valve Replacement in Patients with Chronic Pulmonary Artery Hypertension," Anesthesiology, The Journal of the American Society of Anesthesiologists, Inc., vol. 77, No. 5, pp. 880-883 (Nov. 1992).65Hagenah, Jens-Uwe, "The Use of Nitric Oxide (NO) in Intensive Care Ventilation," Dragerwerk Aktiengesellscha, pp. 1 and 3-36.66Hanson, S. R. et al., "Nitric Oxide Donors: A Continuing Opportunity in Drug Design," Nitric Oxide Biochemistry, Molecular Biology, and Therapeutic Implications, Advances in Pharmacology, vol. 34, pp. 383-398 (1995).67Hartford, William E.; Nitric Oxide as a Bactericidal Agent: Is the Cure Worse Than the Disease?; Respiratory Care, Nov. 2005, vol. 50, No. 11.68Haworth, S. G., "Pulmonary Hypertension in Childhood," The European Respiratory Journal, vol. 6, No. 7, pp. 1037-1043 (Jul. 1993).69Hendrickson, D.A. et al, "Regents and Stains," Manual of Clinical Microbiology, 5th Ed., American Society for Microbiology, pp. 1289-1314 (1991).70Hess, D., RRT, Ph.D., et al., "Delivery Systems for Inhaled Nitric Oxide," Respiratory Care Clinics of North America, vol. 3, No. 3, pp. 371-410 (Sep. 1997).71Hiesmayr, M. J., et al., "Performance of Proportional and Continuous Nitric Oxide Delivery Systems During Pressure- and Volume-Controlled Ventilation," The British Journal of Anaesthesia, vol. 81, No. 4, pp. 544-552 (Oct. 1998).72Higenbottam, T. W., et al., "Inhaled ‘Endothelium Derived-Relaxing Factor’ (EDRF) in Primary Hypertension (PPH)," Abstract, American Review of Respiratory Disease, Suppl., vol. 137, No. 4, Part 2, p. 107 (Apr. 1988).73Higenbottam, T. W., et al., "Inhaled 'Endothelium Derived-Relaxing Factor' (EDRF) in Primary Hypertension (PPH)," Abstract, American Review of Respiratory Disease, Suppl., vol. 137, No. 4, Part 2, p. 107 (Apr. 1988).74Higenbottam, T., "Inhaled Nitric Oxide: A Magic Bullet?" Quarterly Journal of Medicine, vol. 86, pp. 555-558 (1993).75Higenbottam, T., "Nitric Oxide and the Lung," Horizons in Medicine, No. 7 pp. 203-224 (1996).76Higenbottam, T., "Primary Pulmonary Hypertension," British Medical Journal, vol. 293, pp. 1456-1457 (Dec. 1986).77Higenbottam, T., et al., "Acute and Chronic Hypoxic Pulmonary Hypertension," The European Respiratory Journal, vol. 6, No. 8, pp. 1207-1212 (Sep. 1993).78Higenbottam, T., et al., "Has the Treatment of Asthma Improved?" Chest, vol. 98, No. 3, pp. 706-712 (Sep. 1990).79Higenbottam, T., et al., "Highlights on Pulmonary Hypertension: A Commentary," The European Respiratory Journal, vol. 6, No. 7, pp. 932-933 (Jul. 1993).80Higenbottam, T., et al., "Primary and Secondary Pulmonary Hypertension," Seminars in Respiratory and Critical Care Medicine, vol. 19; No. 1, pp. 91-95 (1998).81Higenbottam, T., et al., "Primary Pulmonary Hypertension," British Medical Journal, vol. 294, p. 705 (Mar. 1987).82Higenbottam, T., et al., "The Treatment of Primary Pulmonary Hypertension," Therapeutic Applications of Iloprost, A Volume in the Clinical Monograph Series, pp. 35-41 (Apr. 1995).83Higenbottam, T., et al., "Treatments for Severe Pulmonary Hypertension," The Lancet, vol. 353, No. 9150, pp. 338-340 (Jan. 1999).84Hoehn T., M.D., et al., "Effect of Therapeutic Concentrations of Nitric Oxide on Bacterial Grown in Vitro," Crit Care Med, vol. 26, No. 11, pp. 1857-1862 (1998).85Hudome, S. M., M.D., et al., "Precise Control of Nitric Oxide Concentration in the Inspired Gas of Continuous Flow Respiratory Devices," Pediatric Pulmonology, vol. 22, No. 3, pp. 182-187 (Sep. 1996).86Hugod, C., "Effect of exposure of 43 PPM nitric oxide and 3.6 PPM nitrogen dioxide on rabbit lung," Arch. Occup. Environ. Health 42:159-167 (1979).87Ignarro, L. J., et al., "Endothelium-Derived Relaxing Factor and Nitric Oxide Possess Identical Pharmacologic Properties as Relaxants of Bovine Arterial and Venous Smooth Muscle," The Journal of Pharmacology and Experimental Therapeutics, vol. 246, No. 1, pp.88Ignarro, L. J., et al., "Endothelium-Derived Relaxing Factor Produced and Released From Artery and Vein is Nitric Oxide," Proceedings of the National Academy of Sciences of the United States of America, vol. 84. No. 24, pp. 9265-9269 (Dec. 1987).89Imada, M. et al., "Functional Roles of Nasal Nitric Oxide in Nasal Patency and Mucociliary Function," ACTA Oto-Laryngologica, vol. 122, No. 5, pp. 513-519 (Jul. 2002).90Imanaka, H., M.D., et al., "Inaccuracies of Nitric Oxide Delivery Systems During Adult Mechanical Ventilation," Anesthesiology, vol. 86, No. 3, pp. 676-688 (Mar. 1997).91Ivy, D. D., M.D., et al., "Acute Hemodynamic Effects of Pulsed Delivery of Low Flow Nasal Nitric Oxide in Children with Pulmonary Hypertension," The Journal of Pediatrics, vol. 133, No. 3, pp. 453-456 (Sep. 1998).92Johns, R. A., "EDRF/Nitric Oxide-The Endogenous Nitrovasodilator and a New cellular Messenger," Anesthesiology, The Journal of The American Society of Anesthesiologists, Inc., vol. 75, No. 6. pp. 927-931 (Dec. 1991).93Johns, R. A., "EDRF/Nitric Oxide—The Endogenous Nitrovasodilator and a New cellular Messenger," Anesthesiology, The Journal of The American Society of Anesthesiologists, Inc., vol. 75, No. 6. pp. 927-931 (Dec. 1991).94Kacmarek, R. M., "Nitric Oxide as a Bronchodilator in Methacholine Induced Bronchospasm in Mild Asthmatics," Abstract (1993).95Katayama, Y., et al., "A Minimal Dose of Inhaled Nitric Oxide Delivered As A ‘Spike’ of Small Volume in Early Inhalation," Section of Respiratory Medicine, Division of Clinical Sciences, The Medical School, University of Sheffield (23 pages).96Katayama, Y., et al., "Inhaled Nitric Oxide and Arterial Oxygen Tension in Patients with chronic Obstructive Pulmonary Disease and Severe Pulmonary Hypertension," Thorax, The Journal of the British Thoracic Society, vol. 52, pp. 120-124 (1997).97Katayama, Y., M.D., et al., "Minimizing the Inhaled Dose of NO With Breath-by-Breath Delivery of Spikes of Concentrated Gas," Circulation, Journal of the American Heart Association, vol. 98, No. 22 (Dec. 1998).98Katsuki, S., et al., "Stimulation of Guanylate Cyclase by Sodium Nitroprusside, Nitroglycerin and Nitric Oxide in Various Tissue Preparations and Comparison to the Effects of Sodium Azide and Hydroxylamine," Journal of Cyclic Nucleotide Research, vol. 3. pp. 23-25 (1977).99Keefer, L. K., "Nitric Oxide-Releasing Compounds: From Basic Research to Promising Drugs," The American Chemical Society, vol. 28, pp. 30-35 (Aug. 1998).100Kinsella, J. P., et al., "Hemodynamic Effects of Exogenous Nitric Oxide in Ovine Transitional Pulmonary Circulation," American Journal of Physiology: Heart and Circulatory Physiology, vol. 32, No. 3, pp. H875-H880 (Sep. 1992).101Kinsella, J. P., et al., "Low-Dose Inhalational Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn," The Lancet, vol. 340, pp. 819-820 (Oct. 1992).102Kirov, M. Y., M.D. et al., "Combination of Intravenously Infused Methylene Blue and Inhaled Nitric Oxide Ameliorates Endotoxin-Induced Lung Injury in Awake Sheep," Critical Care Medicine, vol. 31, No. 1, pp. 179-186 (Jan. 2003).103Klein, M.D., et al., "Nitric Oxide Delivery Systems," Acta Anaesthesiologica Scandinavica, pp. 274-275 (1998).104Lechner, M. et al., "Inducible Nitric Oxide Synthase (iNOS) in Tumor Biology: The Two Sides of the Same Coin," Seminars in Cancer Biology, vol. 15, pp. 277-289 (2005).105Leopold, J. A., et al., "New Developments in Nitrosovasodilator Therapy," Vascular Medicine, vol. 2, No. 3 (1997).106Long et al., "Treatment of Sputum-Smear Positive Pulmonary Tuberculosis With Inhaled Nitric Oxide," 2001-Abstract Form to the ATS 2001 San Francisco, May 18-23, 2001 (faxed Mar. 27, 2001).107Long R., et al., "Pulmonary Tuberculosis Treated with Directly Observed Therapy: Serial Changes in Lung Structure and Function," Chest, vol. 113, pp. 933-943 (1998).108Long, R., et al., "Mycobacteriocidal Action of Exogenous Nitric Oxide," Antimicrobial Agents and Chemotherapy, vol. 43, No. 2, pp. 403-405, (Feb. 1999).109Lowenstein, C. J., et al., "Nitric Oxide: a Physiologic Messenger," Annals of Internal Medicine, vol. 120, Issue 3, pp. 227-237 (Feb. 1994).110Mancinelli et al., "Effects of Nitric Oxide and Nitrogen Dioxide on Bacterial Growth," Applied and Environmental Microbiology, vol. 46, No. 1, pp. 198-202 (Jul. 1983).111Mansch, R., et al., "Simulation of Microbiologically and chemically Influenced corrosion of Natural Sandstone," Abstract, ASTM Special Technical Publication, 203-16; 1 pg. (1994).112Maragos, C. M. et al., "Nitric Oxide / Nucleophile Complexes Inhibit the in Vitro Proliferation of A375 Melanoma Cells via Nitric Oxide Release," Cancer Research, vol. 53, pp. 564-568 (Feb. 1, 1993).113Marriott, H., et al., "The Role of Nitric Oxide in Respiratory Disease," Schweiz Med Wochenschr, vol. 127, pp. 709-714 (Apr. 1997).114McMullin, B. B., MSc RRT et al., "The Antimicrobial Effect of Nitric Oxide on the Bacteria That Cause Nosocomial Pneumonia in Mechanically Ventilated Patients in the Intensive Care Unit," Respiratory Care, vol. 50, No. 11, pp. 1451-1456 (Nov. 2005).115Mellgren, K., et al., "Nitric Oxide in the Oxygenator Sweep Gas Reduces Platelet Activation During Experimental Perfusion," The Annals of Thoracic Surgery, vol. 61, No. 4, pp. 1194-1198 (Apr. 1996).116Messent, M., et al., "Pharmacotherapy in Lung Injury," Thorax, vol. 47, No. 7, pp. 651-656 (Jul. 1992).117Meyer, M., et al., "Nitric Oxide (NO), a New Test Gas for Study of Alveolar-capillary Diffusion," The European Respiratory Journal, vol. 2, No. 6, pp. 494-496 (Jun. 1989).118Meyer, M., et al., "Pulmonary Diffusing Capacities for Nitric Oxide and carbon Monoxide Determined by Rebreathing in Dogs," Journal of Applied Physiology, vol. 68, No. 6, pp. 2344-2357 (Jun. 1990).119Miller, Chris C., et al.; "Treatment of Chronic Nonhealing Leg Ulceration with Gaseous Nitric Oxide: A Case Study"; Journal of Cutaneous Medicine and Surgery, pp. 233-238 (2004).120Moinard, J., et al., "Determination of Lung Capillary Blood Volume and Membrane Diffusing capacity in Patients with COLD using the NO-CO Method," The European Respiratory Journal, vol. 3, pp. 318-322 (1990).121Moncada, S., et al., "Nitric Oxide: Physiology, Pathophysiology, and Pharmacology," Pharmacological Reviews, vol. 43, No. 2 (Jun. 1991).122Nablo, B. J. et al., Inhibition of Implant-Associated Infections Via Nitric Oxide Release, Science Direct, Biomaterials, vol. 26, pp. 6984-6990 (May 2005).123Neonatal Inhaled Nitric Oxide Study Group, "Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure," New England Journal of Medicine, 336(9):597-604 (Feb. 1997).124Norman, C., et al., "Nitrogen Oxides in Tobacco Smoke," Nature, vol. 205, No. 4971, pp. 915-916, (Feb. 1965).125Nozaki, Y., et al., "Mechanism of Nitric Oxide-Dependent Killing of Mycobacterium bovis BCG in Human Alveolar Macrophages," Infection and Immunity, vol. 65, pp. 3644-3647 (Sep. 1997).126O'Brien, L., et al., Strains of Mycobacterium Tuberculosis Differ in Susceptibility to Reactive Nitrogen Intermediates in Vitro, Infection and Immunity, vol. 62, No. 11, pp. 5187-5190 (Aug. 1994).127Oda, H., et al., "Nitrosyl-Hemoglobin Formation in the Blood of Animals Exposed to Nitric Oxide," Archives of Environmental Health, vol. 30, No. 7, pp. 453-456 (Sep. 1975).128Palmer, R.M.J., et al., "Nitric Oxide Release Accounts for the Biological Activity of Endothelium-Derived Relaxing Factor," Nature, vol. 327, pp. 524-526 (Jun. 1987).129Pearl, R. G., "Inhaled Nitric Oxide-The Past, The Present and the Future," Anesthesiology, vol. 78, No. 3, pp. 413-416 (Mar. 1993).130Pearl, R. G., "Inhaled Nitric Oxide—The Past, The Present and the Future," Anesthesiology, vol. 78, No. 3, pp. 413-416 (Mar. 1993).131Pearl, R. G., "The Pulmonary Circulation," Anesthesiology, vol. 5, pp. 848-854 (1992).132Pepke-Zaba, J., et al., "Inhaled Nitric Oxide as a Cause of Selective Pulmonary Vasodilatation in Pulmonary Hypertension," The Lancet, vol. 338, No. 8776, pp. 1173-1174 (Nov. 1991).133Pizzichini, M. M. M., et al., "Asthma and Natural Colds: Inflammatory Indices in Induced Sputum: A Feasibility Study," American Journal of Respiratory Critical Care Medicine, vol. 158, pp. 1178-1184 (1998).134Proud, D., "Nitric Oxide and The Common Cold," Journal of Allergy and Clinical Immunology, vol. 5, pp. 37-42 (2005).135Radomski, M. W. et al., "Human Colorectal Adenocarcinoma Cells: Differential Nitric Oxide Synthesis Determines Their Ability to Aggregate Platelets," Cancer Research, vol. 51, pp. 6073-=6078 (Nov. 15, 1991).136Ramnarine, S. I., et al., "Nitric Oxide Inhibition of Basal and Neurogenic Mucus Secretion in Feerrete Trachea in Vitro," British Journal of Pharmacology, vol. 118 (4), pp. 998-1002 (Jun. 1996).137Ray, James D., et al., "A New Method of Preparing Nitric Oxide," Contribution from the Department of Chemistry, Stanford University (1956).138Reynolds, M. M. et al., "Nitric Oxide-Releasing Hydrophobic Polymers: Preparation, Characterization, and Potential Biomedical Applications," Free Radical Biology & Medicine, The Official Journal for the Society for Free Radical Biology and Medicine, vol. 37, No. 7.139Rimmelzwaan, G. F., et al., "Inhibition of Influenza Virus Replication by Nitric Oxide," Journal of Virology, American Society for Microbiology, vol. 73, No. 10, pp. 8880-8883 (Oct. 1999).140Roberts, J. D., et al., "Inhaled Nitric Oxide (NO): A Selective Pulmonary Vasodilator for the Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN)," Abstract 1279, Circulation, vol. 84, No. 4, p. II-321 (Oct. 1991).141Roberts, J. D., et al., "Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn," New England Journal of Medicine, 336:605-610 (Feb. 1997).142Roberts, J. D., et al., "Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn," The Lancet, vol. 340, pp. 818-819 (Oct. 1992).143Rook, G. A. W., "Intractable Mycobacterial Infections Associated with Genetic Defects in the Receptor for Interferon Gamma: What Does This Tell Us About Immunity to Mycobacteria?" Thorax, vol. 52 (Suppl. 3), pp. S41-S46 (1997).144Rossaint, R. et al., "Inhaled Nitric Oxide For The Adult Respiratory Distress Syndrome," New England Journal of Medicine, vol. 328, pp. 399-405 (Feb. 1993).145Rossaint, R., et al., "Successful Treatment of Severe Adult Respiratory Distress Syndrome with Inhaled Nitric Oxide," American Review of Respiratory Disease, Suppl., vol. 145, No. 4, Part 2, p. A80 (Apr. 1992).146Rossiant, R., et al., "Inhaled Nitric Oxide in Contrast to Infused Prostacyclin Selectively Reduces Pulmonary Hypertension and Improves Gas Exchange in Severe ARDS," Abstract, American Review of Respiratory Disease, Suppl., vol. 145, No. 4, Part 2, p. A185 (April.147Sanders, S. P., et al., "Role of Nasal Nitric Oxide in the Resolution of Experimental Rhinovirus Infection," Journal of Allergy and Clinical Immunology, vol. 113, No. 4, pp. 697-702 (Apr. 2004).148Schmidt, I., et al., Physiologic and Proteomic Evidence for a Role of Nitric Oxide in Biofilm Formation by Nitrosomonas europaea and Other Ammonia Oxidizers; Journal of Bacteriology, vol. 186, No. 9, pp. 2781-2788 (May 2004).149Schofnagl, H., et al., "Proportional and Continuous NO Delivery Systems," British Journal of Anaesthesia, vol. 82, No. 4, pp. 647-653 (Apr. 1999).150Shami, P. J. et al., JS-K, A Glutathione/Glutathione S-Transferase-activated Nitric Oxide Donor of the Diazeniumdiolate Class with Potent Antineoplastic Activity, Molecular Cancer Therapeutics, vol. 2, pp. 409-417 (Apr. 2003).151Shank, J.L., et al., "The Effect of Nitric Oxide on Bacteria," Applied Microbio, No. 10, 189-189 (1962).152Snow, D., et al., "Inhaled Nitric Oxide in Pulmonary Hypertension," Journal of Cardiothoracic and Vascular Anesthesia, vol. 8, No. 3, Suppl. 2, Abstract No. 127 (Jun. 1994).153Snyder, S. H., et al., Biological Roles of Nitric Oxide, Scientific American, vol. 266, No. 5, pp. 68-77 (May 1992).154Stavert, D. M. et al., "Nitric Oxide and Nitrogen Dioxide as Inducers of Acute Pulmonary Injury When Inhaled at Relatively High Concentrations for Brief Periods," Inhalation Toxicology 2:53-67 (1990).155Stenqvist, O., et al., "Evaluation of a New System for Ventilatory Administration of Nitric Oxide," Acta Anaesthesiologica Scandinavica, pp. 687-691 (1993).156Swami, A., et al., "The Pulmonary Physician and critical Care: 2. The Injury Lung: Conventional and Novel Respiratory Therapy," Thorax, vol. 47, pp. 555-562 (1992).157Szabo, C., "The Pathophysiological Role of Peroxynitrite in Shock, Inflammation and Ischemia-Reperfusion Injury," Shock, vol. 6, No. 2, pp. 79-88 (1996).158Tamaoki, J., M.D. et al., "Impairment of Airway Mucociliary Transport in Patients with Sinobronchial Syndrome: Role of Nitric Oxide," Journal of Aerosol Medicine, vol. 13, No. 3, pp. 239-244 (Nov. 2000).159Turchi, J. J., "Nitric Oxide and Cisplatin Resistance: NO Easy Answers," PNAS, vol. 103, No. 12, pp. 4337-4338 (Mar. 21, 2006).160Vane, J. R., et al., "Regulatory Functions of the Vascular Endothelium," The New England Journal of Medicine, vol. 323, No. 1, pp. 27-36 (Jul. 1990).161Vijh, A. K., "High Infectious Burden, Low Cancer Incidence, and Early Malignancy in Developing Countries: A Molecular Hypothesis in Term of the Role of Nitric Oxide," Medical Hypotheses, vol. 63, pp. 208-210 (Feb. 2004).162Webert, K. E., M.D., et al., "Effects of Inhaled Nitric Oxide In A Rat Model of Pseudomonas ceruginosa Pneumonia," Crit Car Med, vol. 28, No. 7, pp. 2397-2405 (2000).163Yoshida, J., et al., "Metabolic Fate of Nitric Oxide," Int Arch Occup Environ Health, vol. 46, No. 1, pp. 71-77 (Apr. 1980).164Young, J. D., "A Universal Nitric Oxide Delivery System," British Journal of Anaesthesia, vol. 73, No. 4, pp. 700-702 (Oct. 1994).165Young, J. D., et al., "Delivery and Monitoring of Inhaled Nitric Oxide," Intensive Care Medicine, vol. 22, No. 1, pp. 77-86 (Jan. 1996).Referenced byCiting PatentFiling datePublication dateApplicantTitleUS8282967Jun 24, 2011Oct 9, 2012The University Of North Carolina At Chapel HillNitric oxide-releasing particles for nitric oxide therapeutics and biomedical applicationsUS8591876Dec 14, 2011Nov 26, 2013Novan, Inc.Methods of decreasing sebum production in the skinUS8956658Aug 30, 2013Feb 17, 2015The University Of North Carolina At Chapel HillNitric oxide-releasing particles for nitric oxide therapeutics and biomedical applicationsUS8962029Aug 30, 2013Feb 24, 2015The University Of North Carolina At Chapel HillNitric oxide-releasing particles for nitric oxide therapeutics and biomedical applicationsUS8981139Aug 26, 2013Mar 17, 2015The University Of North Carolina At Chapel HillTertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the sameUS20100098733 *Oct 16, 2009Apr 22, 2010Novan, Inc.Nitric oxide releasing particles for oral care applicationsUS20100228183 *Sep 9, 2010Sunnen Gerard VMethod and apparatus for the deactivation of bacterial and fungal toxins in wounds, and for the disruption of wound biofilmsUS20110086234 *Oct 13, 2010Apr 14, 2011Nathan StaskoNitric oxide-releasing coatingsWO2013040415A1 *Sep 14, 2012Mar 21, 2013The Trustees Of The University Of PennsylvaniaRapid surface disinfection method and apparatus* Cited by examinerClassifications U.S. Classification604/23, 604/290, 604/543, 424/718, 604/540, 604/289International ClassificationA61H33/14, A61B19/00, A61M1/00, A01N59/02, A61M37/00, A61M35/00, A61M13/00, A61M27/00Cooperative ClassificationA61M1/0088, A61M27/00, A61B19/38, A61M35/00, A61M13/003, A61M1/0031, A61M2202/0275, A61H33/14, A61M2205/3334European ClassificationA61M35/00, A61M13/00G, A61M1/00T6Legal EventsDateCodeEventDescriptionApr 7, 2006ASAssignmentOwner name: VIASYS HOLDINGS INC., PENNSYLVANIAFree format text: SECURITY INTEREST;ASSIGNOR:THERANOX, INC.;REEL/FRAME:017435/0358Effective date: 20060331Feb 15, 2008ASAssignmentOwner name: PULMONOX TECHNOLOGIES CORPORATION, CANADAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MILLER, CHRISTOPHER C.;REEL/FRAME:020538/0986Effective date: 20060331Owner name: SENSORMEDICS CORPORATION, CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:STENZLER, ALEX;REEL/FRAME:020538/0106Effective date: 20051019Jul 23, 2014FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services