Source: https://patents.google.com/patent/EP1575421B1/en
Timestamp: 2019-08-22 01:58:43
Document Index: 398661648

Matched Legal Cases: ['art 102', 'art 102', 'art 102', 'art 102', 'art 402', 'art 402', 'art 402', 'art 414', 'art 402']

EP1575421B1 - Devices for minimally invasive cardiac surgery for atrial fibrillation - Google Patents
Devices for minimally invasive cardiac surgery for atrial fibrillation Download PDF
EP1575421B1
EP1575421B1 EP20030790350 EP03790350A EP1575421B1 EP 1575421 B1 EP1575421 B1 EP 1575421B1 EP 20030790350 EP20030790350 EP 20030790350 EP 03790350 A EP03790350 A EP 03790350A EP 1575421 B1 EP1575421 B1 EP 1575421B1
EP20030790350
EP1575421A4 (en
EP1575421A2 (en
2002-12-04 Priority to US310675 priority
2003-12-03 Application filed by ESTECH Inc (Endoscopic Tech Inc) filed Critical ESTECH Inc (Endoscopic Tech Inc)
2003-12-03 Priority to PCT/US2003/038636 priority patent/WO2004049971A2/en
2005-09-21 Publication of EP1575421A2 publication Critical patent/EP1575421A2/en
2007-06-27 Publication of EP1575421A4 publication Critical patent/EP1575421A4/en
2013-10-16 Publication of EP1575421B1 publication Critical patent/EP1575421B1/en
The present invention relates generally to medical devices. More specifically, the invention relates to devices for enhancing minimally invasive cardiac surgery of atrial fibrillation.
Electrophysiologists classify AF by the "three Ps": paroxysmal, persistent, or permanent. Paroxysmal AF—characterized by sporadic, usually self-limiting episodes lasting less than 48 hours—is the most amenable to treatment, while persistent or permanent AF is much more resistant to known therapies. Researchers now know that AF is a self-perpetuating disease and that abnormal atrial rhythms tend to initiate or trigger more abnormal rhythms. Thus, the more episodes a patient experiences and the longer the episodes last, the less chance of converting the heart to a persistent normal rhythm, regardless of the treatment method.
Although cardiac ablation devices and methods are currently available, many advances may still be made to provide improved devices and methods for ablating epicardial tissue to treat AF and other arrhythmias. For example, currently available devices can be difficult to position and secure on epicardial tissue to perform an ablation. Devices such as bipolar ablation clamps and others can ablate tissue only in very limited patterns, such as one or two straight lines. Ablation devices often have no means for shielding ablative energy, to avoid unwanted burning of tissues in the vicinity of the heart, such as the esophagus. Relatively few devices can be secured to epicardial tissue with sufficient force to allow for stabilization of the heart. And many ablation devices may not be introduced by minimally invasive means, thus requiring an open surgical procedure. Typically, therefore, current cardiac ablation procedures for AF treatment still require stopping the heart and using a cardiopulmonary bypass apparatus. Many of these shortcomings are addressed by devices and methods described in co-pending U.S. Patent Application Serial No. 10/272446 , filed by the inventor of the present application on October 13,2002, now US-A-6849075 .
US-A-6036685 describes a method of visualising and treating the heart by providing a balloon end contact scope with a main lumen, an essentially transparent contact viewing port, and integral laser delivery means or other equipment channels suitable for viewing the heart. As shown in Figure 5, a malleable shaft comprises the outer lumen of a catheter device which can be introduced into the chest cavity and positioned adjacent to the posterior surface of the heart. A balloon is attached to the distal end of the device and between the distal end of the device and a contact surface portion of the balloon there is an extruded laser delivery means guide tube. In use, the contact surface of the balloon is placed against the heart surface and a view of the area to be lazed is obtained with a viewing scope or fibre bundle provided within the shaft. US-A-4961738 describes an angioplasty catheter including a light source and eye piece connected by cable to a proximal portion of a stiff catheter of the angioplasty catheter. Optical fibres carrying light from the light source are attached to or embedded in the stiff inner catheter and terminate just inside an inflatable transparent balloon of the angioplasty catheter to illuminate the interior of the balloon and the walls of an artery and plac or other obstruction in the artery.
According to the present invention, there is provided a system as set out in claim 1. Improved methods, devices and systems for minimally invasive cardiac surgery, such as surgery to treat atrial fibrillation, are described. One described method for enhancing visualization of a surgical procedure on a heart of a patient comprises: introducing an elongate visualization device into the patient; advancing the visualization device to position at least one inflatable balloon on the visualization device between the heart and a layer of pericardium adjacent the heart; inflating the at least one inflatable balloon; and using the visualization device to visualize the heart during the surgical procedure. Introducing the visualization device may be accomplished through any suitable incision, such as a subzyphoid incision, a subcostal incision or a thoracotomy. Advancing the visualization device may include advancing the device through the layer of pericardium. Inflating at least one balloon may include inflating one balloon disposed around a circumference of the visualization device. In another example, inflating at least one balloon comprises inflating at least two balloons disposed around a circumference of the visualization device, wherein one balloon is located between the heart and the layer of pericardium and the other balloon is located proximal to the pericardium.
In some examples, the method further includes protecting an optical element of the visualization device by using the balloon to reduce contact of the optical element with other structures. Some examples may also include cleaning the optical element by introducing a fluid through a lumen in the visualization device to contact the optical element. A method may further include introducing an ablation device through a first lumen in the visualization device to contact the heart. Additionally, in some examples the method includes introducing at least one of a clamp, a positioning device, a stabilization device, a cutting device, a cardiac mapping device, a catheter, a left atrial appendage clip applier, an insufflation device and an irrigation device through at least a second lumen in the visualization device. The method may also include: ablating the heart, using the ablation device; removing the ablation device from the first lumen; introducing a left atrial appendage clip applier through the first lumen to contact a left atrial appendage of the heart; and applying at least one clip to the left atrial appendage. In some examples, the method also includes providing light to the visualization device from a control unit; and providing ablation energy to the ablation device from the control unit. Optionally, the method may include providing at least one of insufflation and irrigation to the visualization device from the control unit. Also optionally, the method may comprise recording at least one image acquired by the visualization device on the control unit.
In an example, a visualization device for enhancing minimally invasive heart surgery comprises an elongate visualization member having a proximal end and a distal end and at least one inflatable balloon coupled with the visualization member at or near the distal end. In some embodiments, for example the visualization member comprises an endoscope. Alternatively, the visualization member is selected from the group consisting of an ultrasound device, a fluoroscopy device, an MRI device and a stereotactic positioning device. In some embodiments, the proximal end of the visualization member is removably couplable with an image viewing device. In many embodiments, the device further includes means for inflating the at least one inflatable balloon. For example, the means for inflating may include an infusion lumen for infusing at least one of air or a fluid into the at least one inflatable balloon. The at least one balloon may comprise a first balloon disposed around a circumference of the visualization device such that when the first balloon is inflated it creates a space between a pericardial layer around a heart and an outer surface of the heart. Optionally, the at least one balloon may further comprise a second balloon disposed around the circumference of the visualization device at a location proximal to the first balloon. In some embodiments, the first balloon, when inflated, at least partially protects an optical element of the visualization device from harm due to contact.
The visualization device also includes a first lumen for allowing passage of an ablation device. Optionally, the device may include at least a second lumen for allowing passage of at least one of a clamp, a positioning device, a stabilization device, a cutting device, a cardiac mapping device, a catheter, a left atrial appendage clip applier, an insufflation device and an irrigation device. In some embodiments, the device includes an irrigation lumen for introducing a cleaning fluid to contact and clean an optical element of the visualization device.
A clip applier is described for applying at least one clip to a left atrial appendage of a heart of a patient which comprises: an elongated shaft defining a proximal end and a distal end; clip applying means coupled with the shaft at or near the distal end; and an actuator coupled with the shaft at or near the distal end and also coupled with the clip applying means so as to actuate the applying means to apply the at least one clip to the left atrial appendage. In some embodiments, the device is introducible through a lumen of a visualization device. Optionally, the clip applier may further include at least one clip coupled with the device in a position to allow the clip applying means to apply the clip to the atrial appendage. In some embodiments, the at least one clip does not sever the atrial appendage when applied to the appendage by the clip applying means.
The visualization member, for example, may comprise an endoscope. In other embodiments, the visualization member is selected from the group consisting of an ultrasound device, a fluoroscopy device, an MRI device and a stereotactic positioning device. In some embodiments, the proximal end of the visualization member is removably couplable with an image viewing device. In all other aspects, the visualization device may have any of the features described above or any other suitable features.
In some embodiments, the system further includes a left atrial appendage clip applier for applying at least one clip to the left atrial appendage to reduce or stop blood flow through the appendage.
The inflatable positioning member, for example, may be coupled with the shaft via a flexible joint selected from the group consisting of a ball and socket joint and a ball and collet joint. In other embodiments, the system includes at least one retractor device for facilitating introduction of the visualization device. Optionally, the at least one retractor device includes at least one retractor blade having a cushioned surface for reducing damage to a nerve when the cushioned surface contacts the nerve. For example, the nerve may be an intercostal nerve when the retractor device retracts a rib of a patient.
In some embodiments, the system further comprises a control unit for coupling with at least the visualization device and the ablation device. The control unit may comprise, for example, a light source for providing light to the visualization device and an ablative energy source for providing ablative energy to the ablation device. In some embodiments, the control unit further comprises: a video source for coupling with the visualization device; at least one of an insufflation source and an irrigation source for providing insufflation and/or irrigation to the visualization device; and a power cord for connecting the control unit with a power source. Even further, the control unit may comprise an image recorder for recording images from the visualization device. In some embodiments, the ablative energy source of the control unit provides at least one of RF energy, cryogenic energy and microwave energy.
A control unit is described for enhancing a minimally invasive surgical procedure on a heart of a patient comprises a light source for providing light to the visualization device and an ablative energy source for providing ablative energy to the ablation device. As mentioned above, the control unit may further comprise a video source for coupling with the visualization device; at least one of an insufflation source and an irrigation source for providing insufflation and/or irrigation to the visualization device; and a power cord for connecting the control unit with a power source. Any other suitable feature may be included.
FIG. 1 is a schematic representation of a patient, showing a single-entry device for performing and viewing a cardiac surgery procedure.
FIG. 2 is a schematic representation of a patient, showing a multiple-entry device for performing and viewing a cardiac surgery procedure.
There are described devices, systems and methods that provide for enhancement of heart surgery procedures. Generally, a system embodying the invention provides for enhanced visualisation of a surgical site on, around or near a patient's heart via the use of one or more devices. Various embodiments also provide additional features, such as improved access to the surgical site, prevention of clot dispersal from the left atrial appendage, improved heart positioning and stabilization and/or the like. The invention may be used to enhance any of a number of minimally invasive cardiac surgery procedures, such as ablation procedures for treating atrial fibrillation and the like. Thus, although the description below generally relates to ablation procedures for treating atrial fibrillation, any other suitable procedure may incorporate methods, devices and/or systems of the present invention. Various embodiments of the invention may be used in procedures involving a stopped heart and cardiopulmonary bypass, partial bypass, or in beating heart procedures.
Referring now to Figure 1, a schematic view of a patient 100 is shown, with a representation of a heart 102 and a visualization device 104 in position to visualize a portion of heart 102. Generally, visualization device 104 may comprise any suitable device for enhancing visualization of a surgical field and/or heart 102. For example, in some embodiments visualization device 104 comprises an endoscope, such as commercially available endoscopes or endoscopes developed in the future. Such endoscopes may be flexible, rigid, or partially flexible and partially rigid. In other embodiments, any other suitable visualization devices may be used, such as ultrasound devices, fluoroscopic devices, MRI devices, stereotactic positioning devices or the like.
Visualization device includes at least one inflatable balloon 107 at or near its distal end. As will be described further below, balloon 107 may enhance visualization with visualization device 104, protect optical elements of the device 104, help maintain a position of the device 104 and/or perform other functions. Typically, visualization device 104 is coupled at or near its proximal end with a control unit (not shown), for example a unit including a light source, via a connector 108. It will be understood by those skilled in the art that multiple connectors 108 may be used to couple visualization device 104 to one or more control units for multiple purposes. For example, separate connectors 108 may be used for coupling with a light source, a source of insufflation, a source of irrigation, a video monitor or other image capture device and/or the like.
In some embodiments, one or more additional devices may be introduced into patient 100 via visualization device 104. An ablation device 106 for ablating a pattern on heart 102 for treating atrial fibrillation may be introduced via visualization device 104. Often, additional devices such as ablation device 106 are introduced through one or more lumens on visualization device 104. Ablation device 106 may be any suitable ablation device, such as a radio frequency (RF) device or the like. In some embodiments, ablation device may comprise one or more of the devices described in U.S. Patent Application Serial No. 10/272446 ( US-A-6849075 ).
Ablation device 106 is typically connected, at or near its proximal end, to a controller device (not shown), for activating an ablation member and the like. As described further below, any suitable combination of instruments, devices and the like may be introduced through access device 104.
Referring now to Figure 2, in some surgical procedures, additional devices may be used and additional incisions may be made on patient 100. Generally, visualization device 104 of Figs. 1 and 2 may be introduced into the patient and advanced to the surgical site via any suitable incision, as described above. To facilitate introduction of visualization device 104, one or more retractors 210 may be used to increase the size of an incision. One or more additional incisions on patient 100 may include, for example, an arterial/venous access incision 212a for providing access for a perfusion cannula to a cardiopulmonary bypass machine or for any other device, an incision for a separately-introduced left atrial appendage clamp or clip 212b, and/or a femoral incision 212c for providing access to a femoral artery for entry of a mapping catheter or any other device. Any suitable combination of incisions 212 and devices is contemplated within the scope of the invention.
Referring now to Figures 3A-3C, several different types of visualization devices are shown, each in relation to skin (SK), pericardium (PC) and a heart (H) of a patient (none of which are drawn to scale.) In one embodiment, with reference to Figure 3A, a visualization device 304 is coupled with an insertion needle 302, which comprises a thin, elongate needle-like device or sheath-like device for aiding delivery of visualization device 304 to a desired location. Insertion needle 302 is typically a small-profile device, perhaps between 1-3 mm, to allow for minimally invasive introduction of visualization device 304. Figure 3B shows a visualization device 310 configured for introduction through a trocar 312 or other, similar introducer sheath or device. In some embodiments, visualization device 310 includes both a visualization member 305 and one or more lumens 314 for allowing introduction of ablation devices or the like.
As shown in Figure 3C, another embodiment of a visualization device 330 may be used in conjunction with one or more retractors 320 for facilitating entry of visualization device 330 into the patient. Retractors 320 may comprise any suitable retractor devices. In one embodiment, retractors 320 include one or more hinges to help retractors 320 conform to a body surface. In another embodiment, retractor blades include a pliant, cushioning or otherwise trauma-reducing surface for reducing damage to a nerve with which retractor 320 comes in contact. Any suitable retractors 320 and retractor blades are contemplated. In some embodiments, visualization device 330 also includes one or more inflatable balloons 322 disposed along it outer surface. Inflatable balloons 322 are typically located at or near the distal end of visualization device 303, such that when inflatable balloons 322 are inflated at least one balloon 322 is located between heart H and pericardium PC. Balloon 322 may thus create a space between heart H and pericardium PC to facilitate visualization of heart H. One or more balloons 322 may also partially or completely cover visualization member 305 to protect one or more optical elements of the member 305. In some embodiments, balloon(s) 322 also help maintain visualization device in a desired location. Generally, inflatable balloons 322 may have any desired configuration and may be inflated via any suitable means, such as by an inflation lumen in visualization device 330 coupled with a source of air or other inflation medium.
Referring now to Figures 3D and 3E, a side view and a perspective view of a distal end of a visualization device 340 with an inflatable balloon 342 are shown, respectively. As can be seen from these views, balloon 342 may be configured to cover or otherwise protect an optical element 344 of visualization device 340. In this example, optical elements 344 are recessed from the distal end of balloon 342, as shown by the shaded surface in Figure 3E. As should be understood by those skilled in the art, any other configuration of inflatable balloon 342, or any combination of balloons, may be used without departing from the scope of the invention.
With reference now to Figure 4, a schematic representation of a surgical site is shown from the perspective of an inferior heart surface 402. A surgical system 400 for performing heart surgery according to the present invention may include multiple devices. Typically, at least one visualization device 404 will be used, in some embodiments having one or more lumens 406 for introducing one or more additional devices to the surgical site. Thus, additional devices may be introduced through lumen(s) in visualization device 404, but they may alternatively be introduced through separate incisions, or through both visualization device 404 and separate incisions. For example, an ablation device 405 may be introduced through visualization device 404, as described above. Other devices may be introduced either separately or through visualization device. Such devices include a device for deflating the left lung 403 (device not shown) to allow greater access to and visibility of the heart 402. Additionally, one or more catheters 412 may be used to decompress the heart 402, for example by partially or completely blocking one or more blood vessels such as the aorta 405. An inflatable positioning device 410 may be used to position the heart 402, a heart retractor 414 may be further used to position the heart 414, and one or more stabilizers 416 may be used to maintain a position of the heart.
It should be understood, from Figure 4, that any suitable combination of devices, introduced into a patient via any suitable combination of minimally invasive incisions, is contemplated within the scope of the present invention. One embodiment, for example, may employ one or more ablation devices described in U.S. Patent Application Serial No. 10/272446 . Some embodiments may use retractors as described in U.S. Patent No. 6,309,349 , entitled "Surgical Retractor and Stabilizing Device and Method for Use," the entire disclosure of which is hereby incorporated by reference. Any other suitable devices may be used along with visualization device 404 to enhance minimally invasive surgery on the heart 402 via surgical system 400.
Referring now to Figure 5A, one of the devices in surgical system 400 may include a heart retractor 500. Heart retractor 500 suitably includes a retracting surface 502 coupled with an elongate shaft 540 via a flexible connector 506 such as a ball and socket joint or ball and collet joint. Elongate shaft 540 may be coupled at its proximal end with a rapid disconnect coupling mechanism 508. Rapid disconnect 508 may, in turn, comprise a flexible segment 510 for enhancing maneuverability. In one embodiment, rapid disconnect 508 may be coupled, at its proximal end, with a stable structure, such as an arm of an operating table, to maintain the position of the heart retractor 500.
With reference to Figure 5B, another device which may be used with surgical system 400 comprises an inflatable heart retractor 520 or "pillow retractor." Inflatable retractor 520 comprises an inflatable retractor surface 522, coupled with an elongate shaft 528 via a flexible connector 526. Again, shaft 528 is coupled with a rapid disconnect 530, which may or may not include a flexible segment 532. Inflatable retractor 520 also includes means for inflating the retractor surface 522, which may comprise, for example, an inflation cannula 524 within or outside of elongate shaft 528. Inflatable heart retractor 520 may be particularly advantageous in positioning the heart by placing the inflatable surface 522 in contact with a posterior portion of the heart and inflating the surface 522 to move the heart in an anterior direction--i.e., closer to the surgeon. Creating a space behind the heart may be very advantageous in visualizing the back of the heart and/or in maneuvering one or more surgical devices to operate on the back of the heart.
With reference now to Figure 5C, one device which may be introduced via a visualization device of the invention or via a separate incision on a patient comprises a left atrial appendage clip applier 630. Clip applier 630 is typically used to apply one or more clips to the left atrial appendage of the heart to prevent clots from the left atrial appendage from embolizing and causing harm to the patient, such as a stroke. Clip applier 630 suitably includes a clamp 632 or other means for applying a clip 634, coupled with an elongate shaft 636, which in turn is coupled with a handle 638 for operating the clamp 632. Clip applier 630 will generally have a shape and profile which will allow it to be introduced either through a visualization device of the present invention or via a separate incision. Clips 634 are typically configured to segregate the left atrial appendage without severing the appendage, but otherwise any suitable configuration is contemplated, such as a U-shaped clip or the like. In one embodiment, clip applier 630 may be used to simultaneously clip and excise the atrial appendage.
Referring now to Figure 6A, another embodiment of a visualization device 601 is shown. Again, as has been described above, viewing device comprises often a scope, such as an endoscope, and includes an optical or visualization element 604 and one or more connectors 605 for connecting to a light source and/or other devices. Visualization device 601 also includes at least one inflatable balloon 607, as discussed above, for enhancing visualization and/or for protecting optical element 604. In many embodiments, visualization device 601 also includes one or more lumens for allowing introduction of an ablation device or any other suitable device(s). In some embodiments, such as the embodiment in Figure 6A with one lumen, the profile of visualization device 601 may be quite small. For example, the device 601 may have an outer diameter of between about 1 mm and about 3 mm.
In another embodiment, as shown in Figure 6B, a visualization device 612 may have multiple lumens 614 for allowing introduction of multiple devices. Again, a balloon 615 and an optical element 616 will be included. Multiple lumens 614 may provide means for passage, for example, of a clamp 618 or positioning device, an ablation device 620, cutting apparatus 622, an irrigation or insufflation cannula 624, a mapping catheter 626, or any other suitable device.
Finally, with reference now to Figure 7, many of the devices in surgical system 400 described above may be coupled with a common control unit 800. Control unit 800, for example, may include a power switch 802, an outlet for a light cable 804, a light intensity meter 806, an outlet for a video cable 808, an electrical signal mapping component 810, an ablation source outlet 812 for connecting to an ablation device 814, an insufflation/irrigation outlet for coupling with an insufflation/irrigation cannula 816 and a power cord 818 for coupling control unit 800 with an external power source. Thus, a visualization device, for example, may be coupled with control unit 800 via video cable 808 and light cable 804, an ablation device 814 may be coupled with control unit 812 to receive ablative energy, such as RF energy, and multiple other devices and functions may be controlled via control unit. It will be understood by those skilled in the art that other devices and functions, such as any of the devices described above or any other suitable devices, may be coupled with control unit 800 in various embodiments.
A system for performing an ablation procedure on a heart (102) of a patient (100), the system comprising:
a visualization device (104; 404; 612) having a distal end, the visualization device comprising an elongate visualization member having an optical element, a proximal end and a distal end and at least one inflatable balloon (107; 322) coupled at or near the distal end of the visualization member;
an ablation device (106; 405; 814) for ablating a portion of the heart, the ablation device at least partially disposed in a lumen of the visualization device, wherein a distal end of the ablation device extends distally beyond the visualization device distal end; and
a heart positioning device (410) for moving the heart into a desired position, the heart position device comprising an elongate shaft defining a proximal end and a distal end, and an inflatable positioning member coupled with the shaft at or near the distal end.
A system as in claim 1, wherein the at least one balloon (107; 322) comprises a first balloon (107; 322) disposed around a circumference of the visualization device (104; 404; 612) such that when the first balloon is inflated it creates a space between a pericardial layer around a heart and an outer surface of the heart; and at least partially protects the optical element of the visualization device from harm due to contact.
A system as in claim 2, wherein the at least one balloon (107) further comprises a second balloon (322) disposed around the circumference of the visualization device at a location proximal to the first balloon (322).
A system as in claim 1, 2 or 3, wherein the visualization device has at least a second lumen (314; 614) for allowing passage of at least one of a clamp (618), a positioning device, a stabilization device, a cutting device (622), a cardiac mapping device, a catheter (626), a left atrial appendage clip applier, an insufflation device and an irrigation device (624).
A system as in claim 4, further comprising a left atrial appendage clip applier (630) for applying at least one clip to the left atrial appendage to reduce or stop blood flow through the appendage.
A system as in any one of the preceding claims, wherein the inflatable positioning member (410) is coupled with the shaft via a flexible joint selected from the group consisting of a ball and socket joint and a ball and collet joint.
A system as in claim 4, 5, or 6, further comprising at least one retractor device (210; 320; 500; 520) for facilitating introduction of the visualization device, said retractor device comprises at least one retractor blade having a cushioned surface for reducing damage to a nerve when the cushioned surface contacts the nerve.
A system as in any one of the preceding claims, further comprising a control unit (800) for coupling with at least the visualization device and the ablation device, the control unit comprising:
a light source for providing light to the visualization device (104; 404; 612); and
an ablative energy source for providing ablative energy to the ablation device (814).
A system as in claim 8, wherein the control unit (800) further comprises:
a video source for coupling with the visualization device (104; 404; 612);
a power cord (818) for connecting the control unit with a power source.
A system as in claim 9, wherein the control unit (800) further comprises an image recorder for recording images from the visualization device.
A system as in claim 8, 9 or 10 wherein the ablative energy source provides at least one of RF energy, cryogenic energy and microwave energy.
A system as in any of the preceding claims, further comprising an irrigation lumen (614) for introducing a cleaning fluid to contact and clean the optical element of the visualization device (612).
EP20030790350 2001-12-04 2003-12-03 Devices for minimally invasive cardiac surgery for atrial fibrillation Expired - Fee Related EP1575421B1 (en)
US310675 2002-12-04
EP1575421A2 EP1575421A2 (en) 2005-09-21
EP1575421A4 EP1575421A4 (en) 2007-06-27
EP1575421B1 true EP1575421B1 (en) 2013-10-16
EP20030790350 Expired - Fee Related EP1575421B1 (en) 2001-12-04 2003-12-03 Devices for minimally invasive cardiac surgery for atrial fibrillation
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