Source: http://www.google.com/patents/US7486991?dq=5958006
Timestamp: 2015-03-06 20:55:28
Document Index: 427215932

Matched Legal Cases: ['application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10', 'application No. 10']

Patent US7486991 - Baroreflex modulation to gradually decrease blood pressure - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsAn aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex...http://www.google.com/patents/US7486991?utm_source=gb-gplus-sharePatent US7486991 - Baroreflex modulation to gradually decrease blood pressureAdvanced Patent SearchPublication numberUS7486991 B2Publication typeGrantApplication numberUS 10/746,845Publication dateFeb 3, 2009Filing dateDec 24, 2003Priority dateDec 24, 2003Fee statusPaidAlso published asUS8321023, US8626282, US20050149131, US20090143838, US20130079838, US20140121729Publication number10746845, 746845, US 7486991 B2, US 7486991B2, US-B2-7486991, US7486991 B2, US7486991B2InventorsImad Libbus, Julio C. SpinelliOriginal AssigneeCardiac Pacemakers, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (106), Non-Patent Citations (93), Referenced by (45), Classifications (11), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetBaroreflex modulation to gradually decrease blood pressure
The following commonly assigned U.S. patent applications are related, are all filed on the same date as the present application and are all herein incorporated by reference in their entirety: �Baroreflex Stimulation System to Reduce Hypertension,� U.S. patent application No. 10/746,134, filed on Dec. 24, 2003; �Sensing With Compensation for Neural Stimulator,� U.S. patent application No. 10/746,847, filed on Dec. 24, 2003; �Implantable Baroreflex Stimulator with Integrated Pressure Sensor,� U.S. patent application No. 10/745.921, filed on Dec. 24, 2003; �Automatic Baroreflex Modulation Based on Cardiac Activity,� U.S. patent application No. 10/746.846, filed on Dec. 24, 2003; �Automatic Baroreflex Modulation Responsive to Adverse Event,� U.S. patent application No. 10/745,925, filed on Dec. 24, 2003; �Baroreflex Modulation to Gradually Increase Blood Pressure,� U.S. patent application No. 10/746,845, filed on Dec. 24, 2003; �Baroreflex Stimulation to Treat Acute Myocardial Infarction,� U.S. patent application No. 10/745,920, filed on Dec. 24, 2003; �Baropacing and Cardiac Pacing to Control Output,� U.S. patent application No. 10/746,135, filed on Dec. 24, 2003; �Baroreflex Stimulation Synchronized to Circadian Rhythm,� U.S. patent application No. 10/746.844, filed on Dec. 24, 2003; �A Lead for Stimulating the Baroreflex in the Pulmonary Artery,� U.S. patent application No. 10/746.861, filed on Dec. 24, 2003; and �A Stimulation Lead for Stimulating the Baroreceptors in the Pulmonary Artery,� U.S. patent application No. 10/746,852, filed on Dec. 24, 2003.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3650277 *Feb 17, 1970Mar 21, 1972Lkb Medical AbApparatus for influencing the systemic blood pressure in a patient by carotid sinus nerve stimulationUS4397946 *May 26, 1981Aug 9, 1983Mitsubishi Chemical Industries LimitedProcess for preparing androstane steroidsUS4791931Aug 13, 1987Dec 20, 1988Pacesetter Infusion, Ltd.Demand pacemaker using an artificial baroreceptor reflexUS5111815Oct 15, 1990May 12, 1992Cardiac Pacemakers, Inc.Method and apparatus for cardioverter/pacer utilizing neurosensingUS5190035Apr 17, 1986Mar 2, 1993Cardiac Pacemakers, Inc.Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demandUS5199428Mar 22, 1991Apr 6, 1993Medtronic, Inc.Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workloadUS5203326Dec 18, 1991Apr 20, 1993Telectronics Pacing Systems, Inc.Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapyUS5243980Jun 30, 1992Sep 14, 1993Medtronic, Inc.Method and apparatus for discrimination of ventricular and supraventricular tachycardiaUS5318592Sep 14, 1992Jun 7, 1994BIOTRONIK, Mess- und Therapiegerate GmbH & Co., Ingenieurburo BerlinCardiac therapy systemUS5330507Apr 24, 1992Jul 19, 1994Medtronic, Inc.Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmiasUS5356425Jun 24, 1993Oct 18, 1994Medtronic, Inc.Method and apparatus for treatment of atrial fibrillation and flutterUS5411531Sep 23, 1993May 2, 1995Medtronic, Inc.Electrical medical stimulatorUS5437285Nov 30, 1993Aug 1, 1995Georgetown UniversityMethod and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac electrical stabilityUS5507784Apr 6, 1995Apr 16, 1996Medtronic, Inc.Method and apparatus for control of A-V intervalUS5522854May 19, 1994Jun 4, 1996Duke UniversityMethod and apparatus for the prevention of arrhythmia by nerve stimulationUS5578061Oct 3, 1995Nov 26, 1996Pacesetter AbMethod and apparatus for cardiac therapy by stimulation of a physiological representative of the parasympathetic nervous systemUS5658318Sep 28, 1995Aug 19, 1997Pacesetter AbMethod and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response theretoUS5690681Mar 29, 1996Nov 25, 1997Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillationUS5700282Oct 13, 1995Dec 23, 1997Zabara; JacobHeart rhythm stabilization using a neurocybernetic prosthesisUS5707400Sep 19, 1995Jan 13, 1998Cyberonics, Inc.Treating refractory hypertension by nerve stimulationUS5916239Nov 24, 1997Jun 29, 1999Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillationUS6006134Apr 30, 1998Dec 21, 1999Medtronic, Inc.Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibersUS6058331Apr 27, 1998May 2, 2000Medtronic, Inc.Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback controlUS6073048Nov 17, 1995Jun 6, 2000Medtronic, Inc.Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failureUS6134470Nov 9, 1998Oct 17, 2000Medtronic, Inc.Method and apparatus for treating a tachyarrhythmic patientUS6161042May 21, 1999Dec 12, 2000Cardiac Pacemakers, Inc.Rate adaptive cardiac rhythm management device using transthoracic impedanceUS6161048 *Jun 26, 1997Dec 12, 2000Radionics, Inc.Method and system for neural tissue modificationUS6178349Apr 15, 1999Jan 23, 2001Medtronic, Inc.Drug delivery neural stimulation device for treatment of cardiovascular disordersUS6181966Dec 28, 1998Jan 30, 2001Biotronik Mess- und Therapieger{umlaut over (a)}te GmbH & Co.Heart therapy apparatus with therapy correction meansUS6240314Apr 26, 1999May 29, 2001Sorin Biomedica Cardio S.P.A.Heart stimulation device with electrotonic inhibitionUS6272377Oct 1, 1999Aug 7, 2001Cardiac Pacemakers, Inc.Cardiac rhythm management system with arrhythmia prediction and preventionUS6285907May 21, 1999Sep 4, 2001Cardiac Pacemakers, Inc.System providing ventricular pacing and biventricular coordinationUS6292695Jun 17, 1999Sep 18, 2001Wilton W. Webster, Jr.Method and apparatus for transvascular treatment of tachycardia and fibrillationUS6371922Apr 7, 2000Apr 16, 2002Cardiac Pacemakers, Inc.Method for measuring baroreflex sensitivity and therapy optimization in heart failure patientsUS6400982May 7, 2001Jun 4, 2002Cardiac Pacemakers, Inc.Cardiac rhythm management system with arrhythmia prediction and preventionUS6411845Sep 5, 2000Jun 25, 2002Mower Chf Treatment Irrevocable TrustSystem for multiple site biphasic stimulation to revert ventricular arrhythmiasUS6421557Jun 29, 2000Jul 16, 2002Biotronik Mess-und Therapieger�te GmbH & Co. Ingenieurb�ro BerlinMethod for determining the baroreflex latent period and baroreflex sensitivityUS6449507Sep 26, 2000Sep 10, 2002Medtronic, Inc.Method and system for nerve stimulation prior to and during a medical procedureUS6473644Oct 13, 1999Oct 29, 2002Cyberonics, Inc.Method to enhance cardiac capillary growth in heart failure patientsUS6487450Feb 24, 2000Nov 26, 2002Cedars-Sinai Medical CenterSystem and method for preventing Sudden Cardiac Death by nerve sprouting from right stellate ganglionUS6493585May 10, 2001Dec 10, 2002Sorin Biomedica Cardio S.P.A.Heart stimulation device with electrotonic inhibitionUS6511500Jun 6, 2000Jan 28, 2003Marc Mounir RahmeUse of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effectsUS6522926Sep 27, 2000Feb 18, 2003Cvrx, Inc.Devices and methods for cardiovascular reflex controlUS6532388Sep 26, 2000Mar 11, 2003Medtronic, Inc.Method and system for endotracheal/esophageal stimulation prior to and during a medical procedureUS6542774Jul 2, 2001Apr 1, 2003Medtronic, Inc.Method and device for electronically controlling the beating of a heartUS6564096Feb 28, 2001May 13, 2003Robert A. MestMethod and system for treatment of tachycardia and fibrillationUS6611713Nov 30, 2000Aug 26, 2003Patrick SchauerteImplantable device for diagnosing and distinguishing supraventricular and ventricular tachycardiasUS6622041Aug 21, 2001Sep 16, 2003Cyberonics, Inc.Treatment of congestive heart failure and autonomic cardiovascular drive disordersUS6628987Sep 26, 2000Sep 30, 2003Medtronic, Inc.Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegiaUS6985774 *Sep 26, 2001Jan 10, 2006Cvrx, Inc.Stimulus regimens for cardiovascular reflex controlUS7158832Sep 26, 2001Jan 2, 2007Cvrx, Inc.Electrode designs and methods of use for cardiovascular reflex control devicesUS20020025221Aug 29, 2001Feb 28, 2002John JohnsonModular barrier cushion systemUS20020025222Oct 19, 2001Feb 28, 2002Adil AttarOne piece reflective pavement marker and method of makingUS20020026222Nov 30, 2000Feb 28, 2002Biotronik Mess- Und Therapiegeraete Gmbh & CoDevice for regulating heart rate and heart pumping forceUS20020058877Oct 25, 2001May 16, 2002Cardiac Pacemakers, Inc.Method for measuring baroreflex sensitivity and therapy optimization in heart failure patientsUS20020072776Nov 9, 2001Jun 13, 2002Medtronic, Inc.Vagal nerve stimulation techniques for treatment of epileptic seizuresUS20020077670Sep 11, 2001Jun 20, 2002Archer Stephen T.Stimulation signal generator for an implantable deviceUS20020107553Oct 26, 2001Aug 8, 2002Medtronic, Inc.Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditionsUS20020120304Feb 28, 2001Aug 29, 2002Mest Robert A.Method and system for treatment of tachycardia and fibrillationUS20020143369Oct 26, 2001Oct 3, 2002Medtronic, Inc.Method and apparatus to minimize effects of a cardiac insultUS20020161410 *Apr 27, 2001Oct 31, 2002Kramer Andrew P.Apparatus and method for reversal of myocardial remodeling with electrical stimulationUS20020165586Oct 26, 2001Nov 7, 2002Medtronic, Inc.Closed-loop neuromodulation for prevention and treatment of cardiac conditionsUS20020183237Jan 17, 2002Dec 5, 2002Puskas John D.Methods of performing vagal-induced asystoleUS20030003052Jun 19, 2002Jan 2, 2003Mouse Specifics, Inc.Administering cholinergic agent; determining if elicits a cholinomimetic effect in the subject, as opposed to a cholinergic effect, thereby diagnosing of perturbation of autonomic nervous systemUS20030004549Oct 26, 2001Jan 2, 2003Medtronic, Inc.Method and apparatus to minimize the effects of a cardiac insultUS20030036773Aug 2, 2002Feb 20, 2003Whitehurst Todd K.Systems and methods for treatment of coronary artery diseaseUS20030040774Aug 21, 2001Feb 27, 2003Terry Reese S.Treatment of congestive heart failure and autonomic cardiovascular drive disordersUS20030045909Jul 24, 2002Mar 6, 2003Biocontrol Medical Ltd.Selective nerve fiber stimulation for treating heart conditionsUS20030060848Sep 26, 2001Mar 27, 2003Kieval Robert S.Mapping methods for cardiovascular reflex control devicesUS20030060857Sep 26, 2001Mar 27, 2003Perrson Bruce J.Electrode designs and methods of use for cardiovascular reflex control devicesUS20030060858Sep 26, 2001Mar 27, 2003Kieval Robert S.Stimulus regimens for cardiovascular reflex controlUS20030074039Jun 14, 2002Apr 17, 2003Puskas John D.Devices and methods for vagus nerve stimulationUS20030078623Oct 22, 2001Apr 24, 2003Weinberg Lisa P.Implantable lead and method for stimulating the vagus nerveUS20030078629Nov 25, 2002Apr 24, 2003Peng-Sheng ChenSystem for preventing Sudden Cardiac Death by nerve sprouting from right stellate ganglionUS20030100924Apr 22, 2002May 29, 2003Foreman Robert D.Cardiac neuromodulation and methods of using sameUS20030105493Dec 5, 2001Jun 5, 2003Salo Rodney W.Method and apparatus for minimizing post-infarct ventricular remodelingUS20030149450Feb 3, 2003Aug 7, 2003Mayberg Marc R.Brainstem and cerebellar modulation of cardiovascular response and diseaseUS20030212440Jul 16, 2002Nov 13, 2003Boveja Birinder R.Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation systemUS20030229380Oct 31, 2002Dec 11, 2003Adams John M.Heart failure therapy device and methodUS20040010303Mar 27, 2003Jan 15, 2004Cvrx, Inc.Electrode structures and methods for their use in cardiovascular reflex controlUS20040049235 *Aug 28, 2002Mar 11, 2004Deno D. CurtisImplantable medical device for treating cardiac mechanical dysfunction by electrical stimulationUS20040172074Nov 24, 2003Sep 2, 2004Terumo Kabushiki KaishaHeart treatment equipment for treating heart failureUS20040172075Dec 16, 2003Sep 2, 2004Shafer Lisa L.Method and system for vagal nerve stimulation with multi-site cardiac pacingUS20040199210Jun 11, 2003Oct 7, 2004Shelchuk Anne M.Vagal stimulation for improving cardiac function in heart failure or CHF patientsUS20040220621Apr 30, 2003Nov 4, 2004Xiaohong ZhouMethods and apparatus for the regulation of hormone releaseUS20040254616Apr 5, 2004Dec 16, 2004Cvrx, Inc.Stimulus regimens for cardiovascular reflex controlUS20050021092Jun 18, 2004Jan 27, 2005Yun Anthony JoonkyooTreatment of conditions through modulation of the autonomic nervous systemUS20050096705Nov 3, 2003May 5, 2005Pastore Joseph M.Multi-site ventricular pacing therapy with parasympathetic stimulationUS20050131467Nov 2, 2003Jun 16, 2005Boveja Birinder R.Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertensionUS20050143412Dec 17, 2004Jun 30, 2005Puskas John D.Controlled cessation of heart beat during cardiac surgeries by electrical stimulation of the vagus nerve and administration of a combination of drugs; improved surgical technique; Controlled intermittent asystoleUS20050143779Sep 13, 2004Jun 30, 2005Cardiac Pacemakers, Inc.Baroreflex modulation based on monitored cardiovascular parameterUS20050149126Dec 24, 2003Jul 7, 2005Imad LibbusBaroreflex stimulation to treat acute myocardial infarctionUS20050149127Dec 24, 2003Jul 7, 2005Imad LibbusAutomatic baroreflex modulation responsive to adverse eventUS20050149128Dec 24, 2003Jul 7, 2005Heil Ronald W.Jr.Barorflex stimulation system to reduce hypertensionUS20050149129Dec 24, 2003Jul 7, 2005Imad LibbusBaropacing and cardiac pacing to control outputUS20050149130Dec 24, 2003Jul 7, 2005Imad LibbusBaroreflex stimulation synchronized to circadian rhythmUS20050149131Dec 24, 2003Jul 7, 2005Imad LibbusBaroreflex modulation to gradually decrease blood pressureUS20050149132Dec 24, 2003Jul 7, 2005Imad LibbusAutomatic baroreflex modulation based on cardiac activityUS20050149133Dec 24, 2003Jul 7, 2005Imad LibbusSensing with compensation for neural stimulatorUS20050149156Dec 24, 2003Jul 7, 2005Imad LibbusLead for stimulating the baroreceptors in the pulmonary arteryUS20050187584Apr 22, 2005Aug 25, 2005Stephen DenkerVagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillationUS20050187586Feb 24, 2005Aug 25, 2005Biocontrol Medical Ltd.Selective nerve fiber stimulation for treating heart conditionsUS20050197600Dec 10, 2003Sep 8, 2005Schuler Eleanor L.Device and procedure to treat cardiac atrial arrhythmiasUS20050261741May 20, 2004Nov 24, 2005Imad LibbusCombined remodeling control therapy and anti-remodeling therapy by implantable cardiac deviceUS20070038262 *Jul 7, 2006Feb 15, 2007Cvrx, Inc.Baroreflex stimulation system to reduce hypertensionUSRE38705Nov 15, 2001Feb 22, 2005Medtronic, Inc.Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers* Cited by examinerNon-Patent CitationsReference1"Devices and Methods for Cardiovascular Reflex Control", Provisional U.S. Appl. No. 60,368,222, filed Mar. 27, 2002, 146 Pages.2"Preliminary Statement U.S. Appl. No. 11/482,225 dated Oct. 31, 2006", 2 Pages.3"Preliminary Statement U.S. Appl. No. 11/482,264, Dated Oct. 30, 2006", 1 page.4"Preliminary Statement U.S. Appl. No. 11/482,453, Dated Oct. 31, 2006", 3 Pages.5"Preliminary Statement U.S. Appl. No. 11/482,505, Dated Oct. 31, 2006", 2 Pages.6"Preliminary Statement U.S. Appl. No. 11/482,563, Dated Oct. 31, 2006", 2 Pages.7"Preliminary Statement U.S. Appl. No. 11/482,635, Dated Oct. 31, 2006", 2 Pages.8"Preliminary Statement U.S. Appl. No. 11/482,662 dated Oct. 31, 2006", 2 Pages.9"Substitute Preliminary Statement U.S. Appl. No. 11/428,131 dated Jul. 5, 2006", 2 Pages.10Andersen, H , "Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome", Lancet, 350(9086), (Oct. 25, 1997), 1210-6.11Benchimol, A , "Cardiac hemodynamics during stimulation of the right atrium, right ventricle, and left ventricle in normal and abnormal hearts", Circulation, 33(6), (Jun. 1966),933-44.12Bevan, J A., et al., "Postganglionic sympathetic delay in vascular smooth muscle", Journal of Pharmacology & Experimental Therapeutics, 152(2), (May 1966),221-30.13Bevan, J A., et al., "Sympathetic nerve-free vascular muscle", Journal of Pharmacology & Experimental Therapeutics, 157(1), (Jul. 1967), 117-24.14Bilgutay, A M., et al., "A new concept in the treatment of hypertension utilizing an implantable electronic device: "Baropacer"", Trans Am Soc Artif Intern Organs., 10, (1964),387-95.15Bilgutay, A M., et al., "Vagal tuning for the control of supraventricular arrhythmias", Surgical Forum, 16, (1965), 151-3.16Bilgutay, Aydin M., "Vagal tuning. A new concept in the treatment of supraventricular arrhythmias, angina pectoris, and heart failure", Journal of Thoracic and Cardiovascular Surgery, 56(1), (Jul. 1968),71-82.17Borst, C , et al., "Optimal frequency of carotid sinus nerve stimulation in treatment of angina pectoris", Cardiovascular Research, 8(5), (Sep. 1974),674-8018Braunwald, E , et al., "Carotid sinus nerve stimulation in the treatment of angina pectoris and supraventricular tachycardia", California Medicine, 112(3), (Mar. 1970),41-50.19Braunwald, E , et al., "Relief of angina pectoris by electrical stimulation of the carotid-sinus nerves", New England Journal of Medicine, 277(24), (Dec. 14, 1967),1278-83.20Chapleau, Mark W., "Contrasting effects of static and pulsatile pressure on carotid baroreceptor activity in dogs", Circulation, vol. 61, No. 5, (Nov. 1987),648-658.21Chapleau, Mark W., "Pulsatile activation of baroreceptors causes central facilitation of baroreflex", American Journal Physiol Heart Circ Physiol, (Jun. 1989),256: H1735-1741.22Coleridge, J C., et al., "Relationship between pulmonary arterial pressure and impulse activity in pulmonary arterial baroreceptor fibres", Journal of Physiology, 158, (Sep. 1961),197-205.23Coleridge, J C., et al., "The distribution, connexions and histology of baroreceptors in the pulmonary artery, with some observations on the sensory innervation of the ductus arteriosus", Journal of Physiology, 156, (May 1961),591-602.24Coleridge, J. C., et al., "Reflex effects of stimulating baroreceptors in the pulmonary artery", J. Physiol, 166, (1963),197-210.25Cooper, T B., et al., "Neural effects on sinus rate and atrioventricular conduction produced by electrical stimulation from a transvenous electrode catheter in the canine right pulmonary artery", Circulation Research, 46(1), (Jan. 1980),48-57.26Courtice, G P., et al., "Effect of frequency and impulse pattern on the non-cholinergic cardiac response to vagal stimulation in the toad, Bufo marinus", Journal of the Autonomic Nervous System, 48(3), (Aug. 1994),267-72.27Dart Jr., C H., et al., "Carotid sinus nerve stimulation treatment of angina refractory to other surgical procedures", Annals of Thoracic Surgery, 11(4), (Apr. 1971),348-59.28De Landsheere, D , et al., "Effect of spinal cord stimulation on regional myocardial perfusion assessed by positron emission tomography", American Journal of Cardiology, 69(14), (May 1, 1992),1143-9.29Dunning, Arend J., "Electrostimulation of the Carotid Sinus Nerve in Angina Pectoris", University Department of Medicine, Binnengasthuis, Amsterdam; Printed by Royal Van Gorcum, Assen, Netherlands, (1971),1-92.30Epstein, S E., et al., "Treatment of angina pectoris by electrical stimulation of the carotid-sinus nerves", New England Journal of Medicine, 280(18), (May 1, 1969),971-8.31Farrehi, C , "Stimulation of the carotid sinus nerve in treatment of angina pectoris", American Heart Journal, 80(6), (Dec. 1970),759-65.32Feliciano, L, et al., "Vagal nerve stimulation releases vasoactive intestinal peptide which significantly increases coronary artery blood flow", Cardiovascular Research, 40(1), (Oct. 1998),45-55.33Fromer, M , et al., "Ultrarapid subthreshold stimulation for termination of atrioventricular node reentrant tachycardia", Journal of the American College of Cardiology, 20(4), (Oct. 1992),879-83.34Grassi, Guido , et al., "Baroreflex and non-baroreflex modulation of vagal cardiac control after myocardial infarction", Am J Cardiol., 84(5), (Sep. 1, 1999),525-9.35Griffith, Lawrence S., et al., "Electrical Stimulation of the Carotid Sinus Nerve in Normotensive and Renal Hypertensive Dogs", Circulation, 28, (Jul.-Dec. 1963),730.36Heil, Jr., Ronald W., et al., "Barorelflex Stimulation System to Reduce Hypertension", U.S. Appl. No. 10/746,134, filed Dec. 24, 2003, 78 pgs.37Henning, R J., "Effects of autonomic nerve stimulation, asynchrony, and load on dP/dtmax and on dP/dtmin", American Journal of Physiology, 260(4 Pt 2), (Apr. 1991),H1290-8.38Henning, R J., et al., "Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate", Cardiovascular Research, 32(5), (Nov. 1996),846-53.39Henning, R J., et al., "Vagal stimulation attenuates sympathetic enhancement of left ventricular function", American Journal of Physiology, 258(5 Pt 2), (May 1990),H1470-5.40Hood Jr., W B., et al., "Asynchronous contraction due to late systolic bulging at left ventricular pacing sites", American Journal of Physiology, 217(1), (Jul. 1969),215-21.41Ishise, H , "Time course of sympathovagal imbalance and left ventricular dysfunction in conscious dogs with heart failure", Journal of Applied Physiology, 84(4), (Apr. 1998), 1234-41.42Jessurun, G A., et al., "Coronary blood flow dynamics during transcutaneous electrical nerve stimulation for stable angina pectoris associated with severe narrowing of one major coronary artery", American Journal of Cardiology, 82(8), erratum appears in Am J Cardiol Feb. 15, 1999;83(4):642,(Oct. 15, 1998),921-6.43Kandel, Eric R., et al., "Part VII: Arousal, Emotion, and Behavioral Homeostasis", In: Principles of neural science, New York : McGraw-Hill, Health Professions Division,(2000),966-969.44Karpawich, P P., et al., "Altered cardiac histology following apical right ventricular pacing in patients with congenital atrioventricular block", Pacing Clin Electrophysiol., 22(9), (Sep. 1999), 1372-7.45Kieval, Robert, et al., "Devices and Methods for Cardiovascular Reflex Control", U.S. Appl. No. 10/284,063, filed Oct. 29, 2002, 52 Pages.46Leclercq, C , et al., "Hemodynamic importance of preserving the normal sequence of ventricular activation in permanent cardiac pacing", Am Heart J., 129(6), (Jun. 1995), 1133-41.47Li, Meihua , "Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats", Circulation, 109(1), Epub Dec. 8, 2003,(Jan. 6, 2004),1-5.48Libbus, I., "Integrated Lead for Applying Cardiac Resynchronization Therapy and Neural Stimulation Therapy", U.S. Appl. No. 11/077,970, filed Mar. 11, 2005, 67 pgs.49Libbus, I., et al., "Method and Apparatus for Synchronizing Neural Simulation to Cardiac Cycles", U.S. Appl. No. 11/099,141, filed Apr. 5, 2005.50Libbus, Imad , "Automatic Baroreflex Modulation Based on Cardiac Activity", U.S. Appl. No. 10/746,846, filed Dec. 24, 2003, 83 pgs.51Libbus, Imad , "Automatic Baroreflex Modulation Responsive to Adverse Event", U.S. Appl. No. 10/745,925, filed Dec. 24, 2003, 81 pgs.52Libbus, Imad , "Baroreflex Modulation Based on Monitored Cardiovascular Parameter", U.S. Appl. No. 10/939,544, filed Sep. 13, 2004, 75 pgs.53Libbus, Imad , "Baroreflex Stimulation Synchronized to Circadian Rhythm", U.S. Appl. No. 10/746,844, filed Dec. 24, 2003, 78 pgs.54Libbus, Imad , "Baroreflex Stimulation to Treat Acute Myocardial Infarction", U.S. Appl. No. 10/745,920, filed Dec. 24, 2003, 78 pgs.55Libbus, Imad , "Baroreflex Stimulator With Integrated Pressure Sensor", U.S. Appl. No. 10/745,921, filed Dec. 24, 2003, 80 pgs.56Libbus, Imad , "Baroreflex Therapy for Disordered Breathing", U.S. Appl. No. 10/864,070, filed Jun. 8, 2004, 71 pgs.57Libbus, Imad , et al., "Baropacing and Cardiac Pacing to Control Output", U.S. Appl. No. 10/746,135, filed Dec. 24, 2003, 79 pgs.58Libbus, Imad , et al., "Lead for Stimulating the Baroreceptors in the Pulmonary Artery", U.S. Appl. No. 10/746,861, filed Dec. 24, 2003, 21 pgs.59Libbus, Imad , et al., "Sensing With Compensation for Neural Stimulator", U.S. Appl. No. 10/746,847, filed Dec. 24, 2003, 79 pgs.60Libbus, Imad , et al., "Sensing with Compensation for Neural Stimulator", U.S. Appl. No. 11/621,194, filed Jan. 9, 2007, 69 pgs.61Mannheimer, C , et al., "Epidural spinal electrical stimulation in severe angina pectoris", British Heart Journal, 59(1), (Jan. 1988),56-61.62Mannheimer, C , et al., "Transcutaneous electrical nerve stimulation (TENS) in angina pectoris", Pain, 26(3), (Sep. 1986),291-300.63Mannheimer, C , et al., "Transcutaneous electrical nerve stimulation in severe angina pectoris", European Heart Journal, 3(4), (Aug. 1982),297-302.64Mazgalev, T N., et al., "Autonomic modification of the atrioventricular node during atrial fibrillation: role in the slowing of ventricular rate", Circulation, 99(21), (Jun. 1, 1999),2806-14.65Millar-Craig, M W., et al., "Circadian variation of blood-pressure", Lancet, 1(8068), (Apr. 15, 1978),795-7.66Minisi, A J., et al., "Regional left ventricular deafferentiation increases baroreflex sensitivity following myocardial infarction", Cardiovasc Res., 58(1), (Apr. 1, 2003), 136-41.67Moffitt, Julia, "Combined Neural Stimulation and Cardiac Resynchronization Therapy", U.S. Appl. No. 11/078,460, filed Mar. 11, 2005, 35 pgs.68Murphy, D F., et al., "Intractable angina pectoris: management with dorsal column stimulation", Medical Journal of Australia, 146(5), (Mar. 2, 1987),260.69Neistadt, A , et al., "Effects of electrical stimulation of the carotid sinus nerve in reversal of experimentally induced hypertension", Surgery, 61(6), (Jun. 1967),923-31.70Pastore, Joseph M., et al., "Multi-Site Ventricular Pacing Therapy With Parasympathetic Stimulation", U.S. Appl. No. 10/700,368, filed Nov. 3, 2003, 18 pgs.71Peters, T K., et al., "Temporal and spatial summation caused by aortic nerve stimulation in rabbits. Effects of stimulation frequencies and amplitudes", Journal of the Autonomic Nervous System, 27(3), (Aug. 1989), 193-205.72Peters, T K., et al., "The principle of electrical carotid sinus nerve stimulation: a nerve pacemaker system for angina pectoris and hypertension therapy", Annals of Biomedical Engineering, 8(4-6), (1980),445-58.73Philbin, D M., et al., "Inappropriate shocks delivered by an ICD as a result of sensed potentials from a transcutaneous electronic nerve stimulation unit", Pacing & Clinical Electrophysiology, 21(10), (Oct. 1998),2010-1.74Prakash, P , et al., "Asymmetrical distribution of aortic nerve fibers in the pig", Anat Rec., 158(1), (May 1967),51-7.75Rosenqvist, M , "The effect of ventricular activation sequence on cardiac performance during pacing", Pacing and Electrophysiology, 19(9), (1996), 1279-1286.76Rushmer, Robert F., "Chapter 5-Systemic Arterial Pressure", In: Cardiovascular dynamics, Philadelphia : Saunders,(1976), 176-216.77Schauerte, P , "Transvenous Parasympathetic Nerve Stimulation in the Inferior Vena Cava and Atrioventricular Conduction", Journal of Cardiovascular Electrophysiology, 11(1), (Jan. 2000),64-69.78Schauerte, P , et al., "Catheter stimulation of cardiac parasympathetic nerves in humans: a novel approach to the cardiac autonomic nervous system", Circulation, 104(20), (Nov. 13, 2001),2430-5.79Schauerte, P , et al., "Ventricular rate control during atrial fibrillation by cardiac parasympathetic nerve stimulation: a transvenous approach", Journal of the American College of Cardiology, 34(7), (Dec. 1999),2043-50.80Schauerte, P N., et al., "Transvenous parasympathetic cardiac nerve stimulation: an approach for stable sinus rate control", Journal of Cardiovascular Electrophysiology, 10(11), (Nov. 1999),1517-24.81Scheiner, Avram , et al., "Stimulation Lead for Stimulating the Baroreceptors in the Pulmonary Artery", U.S. Appl. No. 10/746,852, filed Dec. 24, 2003, 25 pgs.82Scherlag, M A., "Endovascular Neural Stimulation Via a Novel Basket Electrode Catheter: Comparison of Electrode Configurations", Journal of Interventional Cardiac Electropysiology, 4(1), (Apr. 2000),219-224.83Takahashi, N , "Vagal modulation of ventricular tachyarrhythmias induced by left ansae subclaviae stimulation in rabbits", Japanese Heart Journal, 39(4), (Jul. 1998),503-11.84Tse, H F., et al., "Long-term effect of right ventricular pacing on myocardial perfusion and function", J Am Coll Cardiol., 29(4), (Mar. 15, 1997),744-9.85Vanoli, E , "Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction", Circulation Research, 68(5), (May 1991), 1471-81.86Veerman, D P., et al., "Circadian profile of systemic hemodynamics", Hypertension, 26(1), (Jul. 1995),55-9.87Verity, M , et al., "Pulmonary artery innervation: a morphopharmacologic correlation", Proceedings of the Western Pharmacology Society, 8, (1965),57-9.88Verity, M A., et al., "Plurivesicular nerve endings in the pulmonary artery", Nature, 211(48), (Jul. 30, 1966),537-8.89Wallick, D W., "Selective AV nodal vagal stimulation improves hemodynamics during acute atrial fibrillation in dogs", American Journal of Physiology-Heart & Circulatory Physiology, 281(4), (Oct. 2001),H1490-7.90Waninger, M S., et al., "Electrophysiological control of ventricular rate during atrial fibrillation", Pacing & Clinical Electrophysiology, 23(8), (Aug. 2000), 1239-44.91Wiggers, C J., et al., "The muscular reactions of the mammalian ventricles to artificial surface stimuli", American Journal of Physiology, (1925),346-378.92Zhang, Y , et al., "Optimal ventricular rate slowing during atrial fibrillation by feedback AV nodal-selective vagal stimulation", American Journal of Physiology-Heart & Circulation Physiology, 282(3), (Mar. 2002),H1102-10.93Zhou, X , et al., "Prevention of high incidence of neurally mediated ventricular arrhythmias by afferent nerve stimulation in dogs", Circulation, 101(7), (Feb. 22, 2000),819-24.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7643875Dec 24, 2003Jan 5, 2010Cardiac Pacemakers, Inc.Baroreflex stimulation system to reduce hypertensionUS7647114Sep 13, 2004Jan 12, 2010Cardiac Pacemakers, Inc.Baroreflex modulation based on monitored cardiovascular parameterUS7668594Aug 19, 2005Feb 23, 2010Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapiesUS7706884Dec 24, 2003Apr 27, 2010Cardiac Pacemakers, Inc.Baroreflex stimulation synchronized to circadian rhythmUS7761157Feb 16, 2007Jul 20, 2010Cardiac Pacemakers, Inc.Cardiac stimulation and sensing with endolymphatically implanted leadUS7783353 *Nov 9, 2006Aug 24, 2010Cardiac Pacemakers, Inc.Automatic neural stimulation modulation based on activity and circadian rhythmUS7885710Dec 23, 2005Feb 8, 2011Cardiac Pacemakers, Inc.Method and apparatus for tissue protection against ischemia using remote conditioningUS7894896May 11, 2006Feb 22, 2011Cardiac Pacemakers, Inc.Method and apparatus for initiating and delivering cardiac protection pacingUS7917210May 13, 2005Mar 29, 2011Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacingUS7979123Oct 8, 2007Jul 12, 2011Cardiac Pacemakers, Inc.Intermittent stress augmentation pacing for cardioprotective effectUS8000793May 23, 2008Aug 16, 2011Cardiac Pacemakers, Inc.Automatic baroreflex modulation based on cardiac activityUS8121693Oct 23, 2008Feb 21, 2012Cardiac Pacemakers, Inc.Baroreflex stimulation to treat acute myocardial infarctionUS8126559Nov 30, 2004Feb 28, 2012Cardiac Pacemakers, Inc.Neural stimulation with avoidance of inappropriate stimulationUS8126561Nov 5, 2009Feb 28, 2012Cardiac Pacemakers, Inc.Implantable and rechargeable neural stimulatorUS8131362Aug 19, 2009Mar 6, 2012Cardiac Pacemakers, Inc.Combined neural stimulation and cardiac resynchronization therapyUS8131373Mar 30, 2010Mar 6, 2012Cardiac Pacemakers, Inc.Baroreflex stimulation synchronized to circadian rhythmUS8195289Nov 30, 2009Jun 5, 2012Cardiac Pacemakers, Inc.Baroreflex stimulation system to reduce hypertensionUS8200331Nov 4, 2004Jun 12, 2012Cardiac Pacemakers, Inc.System and method for filtering neural stimulationUS8200332Sep 18, 2009Jun 12, 2012Cardiac Pacemakers, Inc.System and method for filtering neural stimulationUS8285389Jul 21, 2010Oct 9, 2012Cardiac Pacemakers, Inc.Automatic neural stimulation modulation based on motion and physiological activityUS8306615Jan 18, 2010Nov 6, 2012Cardiac Pacemakers, Inc.Method and apparatus for delivering chronic and post-ischemia cardiac therapiesUS8321023 *Jan 27, 2009Nov 27, 2012Cardiac Pacemakers, Inc.Baroreflex modulation to gradually decrease blood pressureUS8340764Feb 17, 2011Dec 25, 2012Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacingUS8396552Feb 2, 2011Mar 12, 2013Cardiac Pacemakers, Inc.Method and apparatus for initiating and delivering cardiac protection pacingUS8412326Feb 22, 2010Apr 2, 2013Cardiac Pacemakers, Inc.Pacemaker with vagal surge monitoring and responseUS8483826Mar 17, 2009Jul 9, 2013Cardiac Pacemakers, Inc.Deactivation of intermittent pacing therapyUS8538535Aug 5, 2010Sep 17, 2013Rainbow Medical Ltd.Enhancing perfusion by contractionUS8548586Jan 28, 2009Oct 1, 2013Cardiac Pacemakers, Inc.Configurable intermittent pacing therapyUS8600499Dec 5, 2006Dec 3, 2013Cardiac Pacemakers, Inc.Method and device for cardiac vasoactive therapyUS8615296Mar 6, 2007Dec 24, 2013Cardiac Pacemakers, Inc.Method and apparatus for closed-loop intermittent cardiac stress augmentation pacingUS8626282Nov 15, 2012Jan 7, 2014Cardiac Pacemakers, Inc.Baroreflex modulation to gradually change a physiological parameterUS8626290Aug 16, 2011Jan 7, 2014Enopace Biomedical Ltd.Acute myocardial infarction treatment by electrical stimulation of the thoracic aortaUS8626299Dec 1, 2010Jan 7, 2014Enopace Biomedical Ltd.Thoracic aorta and vagus nerve stimulationUS8634921Feb 22, 2012Jan 21, 2014Cardiac Pacemakers, Inc.Implantable and rechargeable neural stimulatorUS8639322May 30, 2012Jan 28, 2014Cardiac Pacemakers, Inc.System and method for delivering myocardial and autonomic neural stimulationUS8649863Dec 20, 2010Feb 11, 2014Rainbow Medical Ltd.Pacemaker with no productionUS8682434Feb 14, 2012Mar 25, 2014Cardiac Pacemakers, Inc.Neural stimulation with avoidance of inappropriate stimulationUS8768462May 30, 2012Jul 1, 2014Cardiac Pacemakers, Inc.System and method for filtering neural stimulationUS8805501Jan 25, 2012Aug 12, 2014Cardiac Pacemakers, Inc.Baroreflex stimulation to treat acute myocardial infarctionUS8805513Apr 23, 2013Aug 12, 2014Cardiac Pacemakers, Inc.Neural stimulation modulation based on monitored cardiovascular parameterUS8812104Sep 8, 2010Aug 19, 2014Cardiac Pacemakers, Inc.Method and apparatus for automated control of pacing post-conditioningUS8818513Mar 1, 2012Aug 26, 2014Cardiac Pacemakers, Inc.Baroreflex stimulation synchronized to circadian rhythmUS8855762Dec 20, 2012Oct 7, 2014Cardiac Pacemakers, Inc.Method and apparatus for cardiac protection pacingUS8862243Jul 25, 2006Oct 14, 2014Rainbow Medical Ltd.Electrical stimulation of blood vesselsUS8874211Dec 15, 2010Oct 28, 2014Cardiac Pacemakers, Inc.Hypertension therapy based on activity and circadian rhythm* Cited by examinerClassifications U.S. Classification607/44International ClassificationA61N1/362, A61N1/365, A61N1/36Cooperative ClassificationA61N1/3611, A61N1/36114, A61N1/36564, A61N1/36117, A61N1/36053, A61N1/36146European ClassificationA61N1/36Z3JLegal EventsDateCodeEventDescriptionJul 5, 2012FPAYFee paymentYear of fee payment: 4May 26, 2009CCCertificate of correctionJun 11, 2004ASAssignmentOwner name: CARDIAC PACEMAKERS, INC., MINNESOTAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LIBBUS, IMAD;SPINELLI, JULIO C.;REEL/FRAME:014722/0129Effective date: 20040505RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services