Source: https://patents.google.com/patent/US9999459B2/en
Timestamp: 2019-02-17 21:06:59
Document Index: 734634380

Matched Legal Cases: ['§ 371', 'Application No. 10', 'art 15', 'art 16', 'arts 15', 'art 16', 'art 15', 'art\n16', 'art\n17']

US9999459B2 - Vacuum mixing device for bone cement and method for mixing bone cement in said device - Google Patents
Vacuum mixing device for bone cement and method for mixing bone cement in said device Download PDF
US9999459B2
US9999459B2 US14/880,398 US201514880398A US9999459B2 US 9999459 B2 US9999459 B2 US 9999459B2 US 201514880398 A US201514880398 A US 201514880398A US 9999459 B2 US9999459 B2 US 9999459B2
US14/880,398
US20160045242A1 (en
Oliver Bielenstein
Christoph Sattig
Stefan Deusser
Volker Stirnal
2009-03-17 Priority to DE102009013211 priority Critical
2009-03-17 Priority to DE102009013211.2 priority
2009-03-17 Priority to DE102009013211A priority patent/DE102009013211B4/en
2010-03-17 Priority to PCT/EP2010/001665 priority patent/WO2010105807A1/en
2011-11-29 Priority to US201113257031A priority
2012-07-19 First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US9999459(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
2015-10-12 Priority to US14/880,398 priority patent/US9999459B2/en
2015-10-12 Application filed by Stryker European Holdings I LLC filed Critical Stryker European Holdings I LLC
2015-10-15 Assigned to AAP BIOMATERIALS GMBH reassignment AAP BIOMATERIALS GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BIELENSTEIN, OLIVER, DEUSSER, STEFAN, SATTIG, CHRISTOPH, STIRNAL, VOLKER
2015-10-16 Assigned to STRYKER IRELAND LIMITED reassignment STRYKER IRELAND LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: AAP BIOMATERIALS GMBH
2015-12-02 Assigned to STRYKER MEDTECH LIMITED reassignment STRYKER MEDTECH LIMITED NUNC PRO TUNC ASSIGNMENT (SEE DOCUMENT FOR DETAILS). Assignors: STRYKER IRELAND LIMITED
2015-12-02 Assigned to STRYKER EUROPEAN HOLDINGS I, LLC reassignment STRYKER EUROPEAN HOLDINGS I, LLC NUNC PRO TUNC ASSIGNMENT (SEE DOCUMENT FOR DETAILS). Assignors: STRYKER MEDTECH LIMITED
2016-02-18 Publication of US20160045242A1 publication Critical patent/US20160045242A1/en
2018-06-19 Publication of US9999459B2 publication Critical patent/US9999459B2/en
2031-01-06 Adjusted expiration legal-status Critical
B01F15/0205—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartiments or cartridges
B01F15/0212—Piercing, perforating, melting membranes, closures which seal the compartments
B01F15/0222—Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components
B01F15/0223—Feed mechanisms characterized by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
B01F15/0258—Feed mechanisms characterized by the means for feeding the components to the mixer using vacuum, underpressure in a closed receptacle or circuit system
B01F7/00658—Configuration of the rotating axis
B01F7/00683—Construction of the axis
B01F7/007—The axis being a hollow cylinder, e.g. for feeding a component
A61B17/8825—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by syringe details
B01F15/0266—Discharge mechanism
B01F15/0274—Discharge mechanism characterized by the means for discharging the components from the mixer
B01F15/0278—Discharge mechanism characterized by the means for discharging the components from the mixer using pistons or plungers
B01F15/0279—Discharge mechanism characterized by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle
B01F2015/0273—Discharge mechanism using a piston reciprocating in the mixing receptacle
The application relates to a vacuum mixing device for bone cement, where the monomer is pressed into a mixing container due to the surrounding vacuum and a gas volume present in the monomer container.
The present application is a continuation of U.S. patent application Ser. No. 13/257,031 filed Sep. 16, 2011, now U.S. Pat. No. 9,186,635, which application is a national phase entry under 35 U.S.C. § 371 of International Application No. PCT/EP2010/001665 filed Mar. 17, 2010, published as International Publication No. WO 2010/105807 A1, which claims priority from German Patent Application No. 10 2009 013 211.2 filed Mar. 17, 2009, the disclosures of which are incorporated herein by reference.
The invention relates to a vacuum mixing device for bone cement and to a method for producing bone cement.
Mixing devices for bone cement are known.
Such a generic mixing device is shown, for example, in the applicant's German patent application DE 10 2007 041 666 A1. When preparing bone cement, a powder, in particular a PMMA powder, is typically mixed with a liquid monomer. Vacuum mixing systems are known so as to avoid the formation of bubbles and/or to prevent harmful gaseous substances that develop during preparation from escaping into the environment. These are systems in which the mixing container comprises a connection for a vacuum hose, via which the container is placed under a vacuum during the mixing process.
Known conventional system often require relatively complicated operation, in which the user must perform several steps associated with sources of errors. In particular, it is important to precisely adhere to the predefined mixing ratio between the monomer and powder.
For this purpose, for example, systems are known in which the monomer is suctioned into the mixing container based on a vacuum that is present in the mixing container. Such conventional systems generally have a valve through which air can flow into the monomer container, so that the existing liquid is completely discharged from the monomer container. Such a system is described, for example, in the European patent specification EP 0 725 647 B1.
The disadvantage of such a system is that the bone cement can become contaminated with microbes from the ambient air, in particular if this system is not operated in a sterile environment.
In contrast, it is the object of the invention to at least reduce the aforementioned disadvantages of the prior art.
It is in particular an object of the invention to be able to provide a vacuum mixing system for bone cement which enables simple and safe handling.
The object of the invention is already achieved by a vacuum mixing device and by a method for preparing bone cement according to any one of the independent claims.
Preferred embodiments and refinements of the invention are disclosed in the respective dependent claims.
The invention relates first to a vacuum mixing device for bone cement, comprising a mixing chamber in which a monomer can be mixed with the powder. So as to avoid the formation of bubbles and prevent harmful gases from escaping, the mixing chamber can be connected to a vacuum source, in particular to a vacuum pump.
The vacuum mixing device moreover comprises a monomer container, which can be coupled to the mixing chamber. The monomer is preferably already contained in the monomer container upon delivery of the vacuum mixing device and thus does not need to be withdrawn from a separate container and added. The term “can be coupled” means that the vacuum mixing device comprises means for forming a passage in which the monomer flows from the monomer container into the mixing container connected to the monomer container.
According to the invention, the closed monomer container is filled partially with a gas, the volume of which is calculated such that, when a vacuum is present, the monomer is displaced by the gas and thus flows into the mixing container.
The monomer container is preferably not subject to over-pressure, but instead has, for example, substantially atmospheric pressure. This enables a simpler design of the container, and the monomer is prevented from escaping in an uncontrolled manner in the event of damage.
If the monomer container is, for example, under atmospheric pressure and a vacuum source is applied that generates a vacuum of approximately 0.5 bar in the mixing container, the gas volume in the monomer container must consequently account for at least half the volume.
The invention enables an entirely closed design of the vacuum mixing device, so that there is no risk during mixing for microbes from the air that is suctioned in to contaminate the bone cement.
The gas that is used can be air in the simplest case, but other gases, in particular those that form a preserving protective atmosphere, are also conceivable. Nitrogen or a noble gas may also be used, for example.
In a preferred embodiment of the invention, the gas volume is so large that the monomer flows into the mixing container up to a predefined fill level, or fully, when a vacuum is present.
A predefined residual fill quantity can be determined, for example, by the height of the cannula protruding into the monomer container during mixing. Depending on the embodiment, complete emptying of the monomer container is also possible.
In this embodiment of the invention, the amount of liquid to be dispensed can be exactly gauged, because the monomer container is emptied fully automatically and the user has no influence on the residual quantity remaining in the monomer container, as is the case, for example, with filling using a syringe.
In a preferred embodiment of the invention, at least 20%, and more preferably 40%, of the volume of the monomer container is filled with the gas.
In a refinement of the invention, the monomer container has a membrane and the vacuum mixing device comprises a piercing cannula, by means of which the membrane can be pierced and the monomer thus flows via the cannula into the mixing container.
This embodiment of the invention enables, in particular, the use of commercially available monomer vials made of glass, which are provided with a membrane. The monomer is thus stored in a safe and sterile manner in the monomer vial.
The invention further relates to a vacuum mixing device which comprises a mixing container, which can be connected to a vacuum source. The vacuum mixing device comprises a monomer container, which can be coupled to the mixing container.
So as to enable a particularly simple design of the device, the monomer container is disposed on a handle, which can also be used to actuate a mixing blade in the mixing chamber, wherein the monomer can be mixed manually with the powder using this mixing blade by moving the mixing blade up and down.
A rod is connected to the handle so as to move the mixing blade.
According to the invention, the rod is guided in a plate, which can be used as a plunger for expelling the bone cement after the bone cement has been prepared.
The rod preferably comprises a channel, which is used to join the mixing container to the monomer container, which is to say to allow the monomer to flow into the mixing container.
The invention enables a design of a vacuum mixing device which is particularly easy to handle, wherein, as in a preferred embodiment of the invention, the handle together with the monomer container can be broken off after the mixing process is complete and the mixing container is employed as a kind of cartridge in a dosing gun. To this end, the plate, which initially serves to guide the rod, is used as a plunger for pushing the bone cement out of the mixing container.
According to one embodiment of the invention, the monomer container comprises a monomer vial disposed in a receiving unit. This embodiment of the invention makes is possible, among others, to use commercially available monomer vials and, as in a preferred embodiment of the invention, the remaining monomer container does not have to be designed to be vacuum-sealed because, for example, a membrane that is present on the monomer vial can served as a sealing element.
In a special embodiment of the invention, the receiving unit is designed to be telescoping. A monomer vial held in the receiving unit can thus be pushed onto a cannula, for example.
The invention further relates to a vacuum mixing device comprising a mixing chamber and a monomer container, which can be coupled to the mixing chamber.
According to the invention, the monomer container engages in the coupled state and is preferably locked in this engaged state.
Thus, the user cannot break the connection between the monomer container and mixing container once it has been established. The monomer thus enters the mixing container completely, and there is no risk of the user separating the monomer container as a result of improper use before the container is emptied.
In a refinement of the invention, the vacuum mixing device comprises a safety bolt which, upon removal, releases the monomer container for movement into the coupled state. Such a safety container prevents accidental actuation of the device.
The vacuum mixing device preferably comprises means for blocking reinsertion of the removed safety bolt. Once the safety bolt has been pulled, it thus also serves as a tamper-proofing element, making it immediately apparent if the vacuum mixing device has been previously used and therefore consumed.
The invention further relates to a method for preparing bone cement. To this end, a monomer is mixed with a powder in a mixing container and a vacuum is applied to the mixing container, at least while mixing.
According to the invention, when the vacuum is present, the monomer is pressed out of the monomer container into the mixing container by a gas that expands as a result of the vacuum.
The method makes a fully closed design of the mixing system possible.
During preparation, the mixing cup and monomer container are thus preferably protected from the penetration of outside air.
In one embodiment of the invention, the monomer container is pierced by means of a cannula and the monomer is conducted via the cannula into the mixing container.
In this connected position, the monomer container engages such that the inflow of monomer can no longer be interrupted.
In a refinement of the invention, the monomer container is separated from the mixing container after the bone cement has been prepared, and the mixing container is used as a cartridge for a dosing gun.
The invention will be described in more detail hereafter with reference to the drawings, these being FIG. 1 to FIG. 6, which show schematic views of embodiments of the invention.
FIG. 1 to FIG. 4 show schematic views of an exemplary embodiment of a handle comprising a monomer container for a vacuum mixing device according to the invention.
The entire vacuum mixing device will be described in more detail with reference to FIGS. 5 and 6.
FIG. 1 is a schematic view of a monomer container 10 designed as a handle for a mixing blade (not shown). The monomer container 10 has a substantially cylindrical shape and comprises an actuating button 11 for releasing the monomer (not shown).
In order to be able to press the actuating button 11, a safety bolt 12 having a handle 13, which forms a finger hole, is provided, which must be removed first.
After the safety bolt 12 has been removed, the actuating button 11 can be pressed and the monomer flows, with a vacuum in the mixing container, into the mixing container (not shown) via a channel (not shown) that is embedded in the rod 6.
FIG. 2 shows a sectional view of the monomer container 10 shown in FIG. 1 in a starting state, which is to say prior to use.
The monomer container 10 comprises a lower housing part 15 and an upper housing part 16, which is also designed as the actuating button 11.
The housing parts 15, 16 are used to accommodate a commercially available monomer vial 17 made of glass, which is sealed with a membrane 18.
The monomer fills the monomer vial 17 approximately half in this exemplary embodiment. The fill level is predefined by the line 25.
The monomer container 10 further comprises a cannula 19, which is connected to a channel 20 that is embedded in the rod 6.
The cannula 19 and the membrane 18 of the monomer vial 17 are held apart from each other by the safety bolt 12 so that accidental actuation is not possible.
The safety bolt 12 comprises a spring-loaded tongue so as to compensate for manufacturing tolerances of the monomer vial 17.
As soon as the safety bolt 12 has been pulled out, the monomer vial 17 slides into a position in which the safety bolt 12 cannot be re-inserted.
FIG. 3 shows a sectional view of the monomer container 10 after actuation.
When the actuating button is pressed, the upper housing part 16 and the lower housing part 15 are pushed inside each other, whereby the monomer vial 17 is pushed onto the cannula 19 which pierces the membrane 18 so that the monomer can enter the mixing container (not shown) via the channel 20.
Because of the air volume that is present above the fill level 25 and the vacuum that is present in the mixing container, the monomer is emptied to a low residual fill level, which is predefined by the position of the cannula 19.
In order to define an exact position of the cannula 19 relative to the monomer vial 17, a ring 21 is provided in the lower housing part, with the monomer vial 17 being seated on this ring in the actuated state.
FIG. 4 shows a detail view of the head of the monomer container shown in FIG. 3. The engagement of the monomer container will be described in more detail with reference to this figure.
The upper housing part comprises catch hooks 22, which in the actuated state engage beneath catch lugs 23 of the lower housing part. For this purpose, the catch hooks 22 are beveled. It is not possible to pull them apart after engagement.
So as to further increase the protection from manipulation, ribs 24 are provided on the lower housing part, which substantially prevent the use of a tool to push the catch hooks inward from beneath and thus return the monomer vial to the original position.
FIG. 5 is a schematic view of the entire vacuum mixing device.
The monomer container 10 is designed as a handle, which is connected via a rod 6 to a mixing blade (not shown).
The mixing container 2 is preferably already prefilled with the powder.
In order to ensure that the powder does not enter the rod 6, a filter, and more particularly a filter plate, is provided (not shown) at the lower end of the rod.
When the vacuum mixing device 1 is used, a vacuum pump is connected to a vacuum connection 3 on the mixing container 2. A nonwoven fabric (not shown) that is embedded in the vacuum connection prevents bone cement from escaping.
A withdrawal opening, which initially is still screwed to a base 5, is located at the bottom of the mixing container 2.
The user (not shown) first connects the mixing container 2 to the vacuum.
Then, he pulls the safety bolt and pushes the actuating button 11 of the monomer container.
Because of the vacuum, the monomer (not shown) is displaced by the gas trapped in the monomer container 10 and flows via the rod 6 into the mixing container 2. To this end, the rod 6 comprises lateral openings above the mixing blades (not shown).
The user then uses the monomer container 10 as a handle so as to move the mixing blades (not shown) in the mixing container 2 and thus prepare the bone cement.
Thereafter, the user pulls the mixing blade all the way to the top and completely breaks off the rod 6 together with the monomer container 10 at a predetermined breaking point.
Moreover, the user unscrews the base 5, whereby the withdrawal opening is uncovered.
The mixing container 2 can now be utilized as a cartridge for a dosing gun (not shown). To this end, the cover 7 of the mixing container 2, in which the rod 6 is also guided, serves as a plunger. The cover 7 can, for this purpose, be connected to the remaining mixing container 2 so that it detaches at a particular force and can then be pushed forward. The cover can, for example, be pressed into a groove of the cylindrical housing of the mixing container 2.
FIG. 6 shows a further perspective view of a vacuum mixing device 1. In this view, the base (5 in FIG. 5) has already been unscrewed, so that the withdrawal opening 4 is visible.
The invention enables particularly simple and safe handling of bone cement.
The invention is, of course, not limited to a combination of the aforedescribed characteristics, but a person skilled in the art can combine all the features to the extent this is expedient.
1 Vacuum mixing device
2 Mixing container
3 Vacuum connection
4 Withdrawal opening
7 Cover
10 Monomer container
11 Actuating button
12 Safety bolt
15 Lower housing part
16 Upper housing part
17 Monomer vial
18 Membrane
19 Cannula
22 Catch hook
23 Catch lug
24 Rib
25 Fill level
1. A mixing device for preparing bone cement, comprising:
a mixing container;
a monomer container attached to the mixing container and having first and second telescoping parts, the monomer container being moveable relative to the mixing container,
wherein one of the first and second telescoping parts of the monomer container includes at least one catch hook and the other of the first and second telescoping parts of the monomer container includes at least one catch lug for engagement with the respective at least one catch hook such that the monomer container is locked in position relative to the mixing container.
2. The mixing device of claim 1, further comprising a pin for engagement with the monomer container, the pin being disengageable from and removable from the monomer container,
wherein, when the pin is engaged with the monomer container, the first telescoping part of the monomer container does not move relative to the second telescoping part of the monomer container, and, upon removal of the pin, the first telescoping part of the monomer container moves relative to the second telescoping part of the monomer container.
3. The mixing device of claim 2, further comprising a monomer vial disposed in the monomer container, wherein upon removal of the pin, the monomer vial slides toward the mixing container and prevents reinsertion of the pin.
4. The mixing device of claim 2, further comprising a monomer vial disposed in the monomer container,
wherein the pin includes a shaft and a deflectable tongue extending from the shaft, and
wherein, when the pin is engaged with the monomer container, the monomer container rests on the tongue.
5. The mixing device of claim 2, further comprising a cannula attached to the monomer container and configured to pierce a monomer vial when the monomer vial is disposed in the monomer container, wherein when the pin is engaged with the monomer container and the monomer vial is disposed in the monomer container, the pin extends across the monomer container to separate the cannula from the monomer vial.
6. The mixing device of claim 2, wherein the mixing container is connectable to a vacuum source, the mixing device further comprising:
a monomer vial disposed in the monomer container and filled at least partially with a volume of gas; and
a cannula attached to the monomer container and configured to pierce the monomer vial,
wherein when a vacuum is present in the mixing container and the piercing cannula pierces the monomer container, the monomer flows from the monomer container into the mixing container to at least a predefined fill level.
7. The mixing device of claim 6, wherein the at least 20% of the volume of the monomer container is filled with the volume of gas.
8. The mixing device of claim 6, wherein the at least 40% of the volume of the monomer container is filled with the volume of gas.
9. The mixing device of claim 1, wherein the monomer container includes a rod, the monomer container being attached to the mixing container via the rod.
10. The mixing device of claim 9, wherein the monomer container is configured to receive a monomer vial and a channel is disposed in the rod, and wherein monomer from the monomer vial is receivable in the mixing container through the rod.
11. The mixing device of claim 10, further comprising a cannula attached to the monomer container and received in a channel of the rod, the cannula being configured to pierce the monomer vial when the monomer vial is received in the monomer container.
12. The mixing device of claim 9, wherein the mixing container includes a plate, and wherein the rod of the monomer container is guided through the plate, the plate being detachable such that the plate is moveable to expel prepared bone cement.
13. A mixing device for preparing bone cement, comprising:
a rod;
a monomer container attached to the mixing container via the rod and including first and second telescoping parts, the monomer container and the rod being moveable relative to the mixing container;
a cannula attached to the monomer container and having an end received in a channel of the rod, the cannula being configured to pierce a monomer vial when the monomer vial is disposed in the monomer container, wherein when the monomer vial is pierced, monomer flows via the cannula into the mixing container; and
a pin for engagement with the monomer container, the pin being disengageable from and removable from the monomer container, wherein, when the pin is engaged with the monomer container, the first telescoping part of the monomer container does not move relative to the second telescoping part of the monomer container, and, upon removal of the pin, the first telescoping part of the monomer container moves relative to the second telescoping part of the monomer container.
14. The mixing device of claim 13, wherein the monomer vial is disposable between the first and second telescoping parts when the monomer vial is disposed in the monomer container and such that when the first telescoping part is telescoped relative to the second telescoping part from a first position to a second position with the monomer vial is disposed in the monomer container, the monomer vial is pushed onto the cannula.
15. The mixing device of claim 13, further comprising the monomer vial disposed in the monomer container,
16. The mixing device of claim 13, wherein when the pin is engaged with the monomer container and the monomer vial is disposed in the monomer container, the pin extends across the monomer container to separate the cannula from the monomer vial.
17. The mixing device of claim 13, wherein when the monomer vial is pierced, monomer flows via the cannula into the mixing container, wherein the mixing container includes a plate, and wherein the rod of the monomer container is guided through the plate, the plate being detachable such that the plate is moveable to expel prepared bone cement.
18. A mixing device for preparing bone cement, comprising:
a monomer container attached to the mixing container and having first and second telescoping parts, the monomer container being moveable relative to the mixing container; and
a pin for engagement with the monomer container, the pin being disengageable from and removable from the monomer container, wherein, when the pin is engaged with the monomer container, the first telescoping part of the monomer container is prevented from moving relative to the second telescoping part of the monomer container, and, upon removal of the pin, the first telescoping part of the monomer container slides relative to the second telescoping part of the monomer container.
19. A mixing device for preparing bone cement, comprising:
a monomer container attached to the mixing container via the rod, the monomer container and the rod being moveable relative to the mixing container; and
a cannula attached to the monomer container and having an end received in a channel of the rod, the cannula being configured to pierce a monomer vial when the monomer vial is disposed in the monomer container, wherein when the monomer vial is pierced, monomer flows via the cannula into the mixing container, wherein the mixing container includes a plate, and wherein the rod of the monomer container is guided through the plate, the plate being detachable such that the plate is moveable to expel prepared bone cement.
20. A mixing device for preparing bone cement, comprising:
a monomer container attached to the mixing container via the rod, the monomer container and the rod being moveable relative to the mixing container;
a monomer vial disposed in the monomer container; and
a cannula attached to the monomer container and having an end received in a channel of the rod, the cannula being configured to pierce the monomer vial, wherein when the monomer vial is pierced, monomer flows via the cannula into the mixing container, wherein the mixing container is connectable to a vacuum source, the monomer vial being filled at least partially with a volume of gas, and wherein when a vacuum is present in the mixing container and the cannula pierces the monomer vial, the monomer flows from the monomer container into the mixing container to at least a predefined fill level.
US14/880,398 2009-03-17 2015-10-12 Vacuum mixing device for bone cement and method for mixing bone cement in said device Active 2031-01-06 US9999459B2 (en)
DE102009013211 2009-03-17
DE102009013211.2 2009-03-17
DE102009013211A DE102009013211B4 (en) 2009-03-17 2009-03-17 Vacuum mixing device for bone cement and method for mixing bone cement
PCT/EP2010/001665 WO2010105807A1 (en) 2009-03-17 2010-03-17 Vacuum mixing device for bone cement and method for mixing bone cement in said device
US201113257031A true 2011-11-29 2011-11-29
US14/880,398 US9999459B2 (en) 2009-03-17 2015-10-12 Vacuum mixing device for bone cement and method for mixing bone cement in said device
US13/257,031 Continuation US9186635B2 (en) 2009-03-17 2010-03-17 Vacuum mixing device for bone cement and method for mixing bone cement in said device
PCT/EP2010/001665 Continuation WO2010105807A1 (en) 2009-03-17 2010-03-17 Vacuum mixing device for bone cement and method for mixing bone cement in said device
US201113257031A Continuation 2011-11-29 2011-11-29
US20160045242A1 US20160045242A1 (en) 2016-02-18
US9999459B2 true US9999459B2 (en) 2018-06-19
ID=42236502
US13/257,031 Active 2033-03-15 US9186635B2 (en) 2009-03-17 2010-03-17 Vacuum mixing device for bone cement and method for mixing bone cement in said device
US14/880,398 Active 2031-01-06 US9999459B2 (en) 2009-03-17 2015-10-12 Vacuum mixing device for bone cement and method for mixing bone cement in said device
US (2) US9186635B2 (en)
EP (1) EP2408403A1 (en)
AU (1) AU2010225207B2 (en)
CA (1) CA2767465C (en)
DE (1) DE102009013211B4 (en)
RU (1) RU2012112426A (en)
WO (1) WO2010105807A1 (en)
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US20160045242A1 (en) 2016-02-18
DE102009013211B4 (en) 2012-04-19
US20120065642A1 (en) 2012-03-15
AU2010225207B2 (en) 2014-04-03
WO2010105807A1 (en) 2010-09-23
DE102009013211A1 (en) 2010-09-23
EP2408403A1 (en) 2012-01-25
AU2010225207A1 (en) 2012-06-07
US9186635B2 (en) 2015-11-17
CA2767465A1 (en) 2010-09-23
CA2767465C (en) 2018-11-13
RU2012112426A (en) 2013-10-10
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