Source: https://patents.google.com/patent/KR101986447B1/en
Timestamp: 2019-08-25 07:35:16
Document Index: 498064084

Matched Legal Cases: ['art 150', 'art 160', 'art 150', 'art 140', 'art 150', 'art 160', 'art 150', 'art 150', 'art 170']

KR101986447B1 - Partial Milling Screw with Sticky Tape Containing Bone Anabolic Agent for Augmented Osteosynthesis - Google Patents
Partial Milling Screw with Sticky Tape Containing Bone Anabolic Agent for Augmented Osteosynthesis Download PDF
KR101986447B1
KR101986447B1 KR1020180002100A KR20180002100A KR101986447B1 KR 101986447 B1 KR101986447 B1 KR 101986447B1 KR 1020180002100 A KR1020180002100 A KR 1020180002100A KR 20180002100 A KR20180002100 A KR 20180002100A KR 101986447 B1 KR101986447 B1 KR 101986447B1
KR1020180002100A
2018-01-08 Application filed by 경북대학교 산학협력단 filed Critical 경북대학교 산학협력단
2018-01-08 Priority to KR1020180002100A priority Critical patent/KR101986447B1/en
2019-06-05 Publication of KR101986447B1 publication Critical patent/KR101986447B1/en
The present invention relates to a screw for promoting bony union for improving bony union for the treatment of fracture. The screw is inserted into the fracture site of the patient so that the fractured parts are connected to each other, and the fracture line Forming a milling groove in a portion of the screw body to form a thread to be fastened to a fracture site on at least one side thereof; And a bone union promoting tape to which the bone formation promoting drug is applied and which is wound around the milling groove.
{Partial Milling Screw with Sticky Tape Containing Bone Anabolic Agent for Augmented Osteosynthesis}
The present invention relates to a screw for promoting bony union, and more particularly, to a screw for promoting bony union which can improve bony union in screw insertion for fracture treatment.
Long bone (or tubular bone) fracture treatment requires accurate anatomical (pre-fracture bone shape) and bone fracture (bony) (4 to 12 weeks), it is important to fix the fracture surface so that it does not move. At this time, the smaller the gap (gap) of the fracture surface is, the more effective the fracture healing is. Therefore, it is general to press and fix so that there is no gap. For this purpose, metal screws, metal pins, and K-wires are used.
As Korea has recently entered a rapidly aging society, patients with osteoporotic fractures who undergo screw fixation are increasing exponentially. In the case of severe osteoporosis, fracture union is not performed well and serious complications arise such as screw shaking or falling.
Previously, hydroxyapatite coating was applied to the entire screw, or after the hole was drilled in the inside of the screw, the screw was inserted and the drug was injected, but it was not effective.
Korean Patent No. 10-1697252 Korean Patent Publication No. 10-2017-0103001
According to one aspect of the present invention, there is provided a screw for promoting bone union, which can facilitate bone union of a fracture site by milling a part of a screw and then winding a tape having a bone formation promoting drug attached thereto.
The technical problem of the present invention is not limited to the technical problems mentioned above, and other technical problems which are not mentioned can be understood by those skilled in the art from the following description.
According to an embodiment of the present invention, a screw for promoting bone fusion is inserted through a fracture portion of a patient so that fractured portions are connected to each other, and a milling groove is formed at a portion where a fracture line, A threaded body formed on one side to form a thread to be fastened to a fracture site; And a bone union promoting tape to which the bone formation promoting drug is applied and which is wound around the milling groove.
In one embodiment, the milling grooves may be formed as a single piece or a plurality of pieces.
In one embodiment, the bone unification promoting tape has a width and a thickness corresponding to the width and the depth of the milling groove, and the bone formation promoting drug may be applied to one side of the milling groove to be wound on the milling groove.
In one embodiment, the bone-fusion promoting tape may be wound in a single layer or two or more layers in the milling groove in a state in which the portion to which the bone formation promoting drug is applied faces upward.
In one embodiment, the bone unification promoting tape can apply hydroxyapatite as a bone formation promoting agent.
In one embodiment, the milling groove may be formed along the outer surface of the threaded body in correspondence with the shape of a fracture line facing the threaded body.
In one embodiment, the bone-union promoting tape may be cut corresponding to the shape of the milling groove and wound along the milling groove.
According to another embodiment of the present invention, a screw for promoting bone fusion is inserted into a fracture portion of a patient so that the fractured portions are connected to each other, and then the bone formation promoting drug is injected and delivered. When the fracture line Forming a milling groove in a portion of the screw body to form a thread to be fastened to a fracture site on at least one side thereof; And a bone union promoting tape wound around the milling groove and receiving and absorbing a bone formation promoting drug from the screw body.
In one embodiment, the threaded body comprises: a bone connection portion that is inserted through the fracture site of the patient so that the fractured site is connected to each other; A penetration portion formed in the longitudinal direction along the central portion of the bone connection portion so as to allow the bone formation promoting drug to be introduced into the fracture line portion; And a drug delivery unit formed to penetrate from the penetration portion to the portion where the bone-joint promoting tape is wound so that the bone formation promoting drug inserted along the penetration portion can be transmitted to the bone-joint promoting tape.
In one embodiment, at least one or more drug delivery portions may be formed along the milling groove.
According to another aspect of the present invention, there is provided a screw for promoting bone fusion, the screw main body being inserted through a fracture portion of a patient so that the fractured portions are connected to each other and forming a screw thread to be fastened to at least one side of the fracture portion; And a bone union promoting tape to which the bone formation promoting drug is applied and wound along a thread formed by the thread.
In one embodiment, the threaded body comprises: a bone connection portion that is inserted through the fracture site of the patient so that the fractured site is connected to each other; A penetration portion formed in the longitudinal direction along the central portion of the bone connection portion so as to allow the bone formation promoting drug to be introduced into the fracture line portion; And a drug delivery unit formed to penetrate the threaded bone from the penetration part so as to transmit the bone formation promoting drug inserted along the penetration part to the bone fusion promotion tape.
In one embodiment, the threaded body may form a milling groove along the threaded bore to wind the bending fusion promoting tape.
In one embodiment, the screw body may include a fastening portion for fastening one side of the bone-union promotion tape to prevent the bone-union promotion tape from being pushed when the insertion member is inserted into the fracture portion of the patient.
In one embodiment, the fastening portion includes: a fastening groove formed at an inlet portion of the threaded hole; And a fastening bundle formed corresponding to the shape of the fastening groove and having one side connected to the fastening groove so as to be inserted into the fastening groove by pivoting the fastening unit.
In one embodiment, when the fastening bundle is pivotally inserted into the fastening groove, the upper surface may be formed to be flat with the threaded boss.
In one embodiment, the bone-union promotion tape is inserted into an insertion groove formed in a lower portion of the fastening bundle, and is fastened to the fastening groove as the fastening bundle is rotated and inserted into the fastening groove.
According to one aspect of the present invention, a screw is partially milled to make grooves to easily and effectively wrap a tape adhered to a screw, and to prevent peeling of a tape adhered to a drug at the time of screw insertion.
FIG. 1 is a view showing a schematic configuration of a screw for promoting bone fusion according to an embodiment of the present invention.
Fig. 2 is a view for explaining the milling grooves shown in Fig. 1. Fig.
3 is a view for explaining a screw for promoting bone union according to another embodiment of the present invention.
Fig. 4 is a view for explaining the screw main body shown in Fig. 3;
5 is a view for explaining a screw for promoting bone fusion according to another embodiment of the present invention.
Fig. 6 is a view for explaining an embodiment of the screw main body shown in Fig. 5;
7 is a view for explaining another embodiment of the screw body in Fig.
Specifically, the screw 10 for promoting bone fusion according to an embodiment of the present invention includes a screw body 100 and a bone union promotion tape 200.
The threaded main body 100 is inserted into a fracture portion of the patient so that the fractured portions are connected to each other. The milling groove 110 is formed at a portion where a fracture line (fracture line) A thread 120 is formed to be fastened to the fracture site.
In one embodiment, the milling groove 110 is formed with a width of 0.8 mm to 1.2 mm (preferably 1.0 mm) and a depth of 0.3 mm to 0.7 mm (preferably 0.5 mm) And may be formed in one or a plurality corresponding thereto. For example, if the bones of the patient are divided into two or more pieces, it may be formed corresponding to each fracture portion. For example, when the fracture portion is two portions, two milling grooves 110 may be formed, In the case of three parts, three milling grooves 110 may be formed. Fig. 1 illustrates a case where there is one fracture portion.
The bone union promoting tape 200 is coated with a bone formation promoting drug and wound around the milling groove 110. [ At this time, it is preferable that the bone-union promotion tape 200 is made of a material having an adhesive force so that it can be easily prevented from being unwound from the milling groove 110 after being wound around the milling groove 110.
In one embodiment, the bone unification promoting tape 200 is formed to have a width and a thickness corresponding to the width and depth of the milling groove 110, and an osteogenesis promoting medication is applied to one side thereof to be wound on the milling groove 110 have.
In one embodiment, the bone-fusion promoting tape 200 may be wound one or two or more layers in the milling groove 110 with the portion to which the bone formation promoting drug is applied facing upward.
In one embodiment, the bone fusion promoting tape 200 can apply hydroxyapatite as a bone formation promoting agent. However, it is not limited to hydroxyapatite as an osteogenesis promoting drug, but it can be applied as a drug that can promote bone formation.
Here, the hydroxyapatite refers to a hydroxyapatite represented by the formula
, Which is the most thermodynamically stable calcium phosphate compound under physiological conditions. The crystal unit is composed of 18 atomic groups, belonging to the hexagonal system, and unit plant is 6.88 × 9.42 × 9.42 Å. Since the phosphoric acid group, the hydroxyl group and the calcium are exposed in a specific arrangement on the surface of the crystal, any positive or negative total charge can be adsorbed. Originally, minerals are the main component of teeth, and they can be used as materials for artificial organs such as artificial bone and artificial teeth because they can fuse well in tissues and in vivo. On the other hand, it can be used as a cell supporter in cell culture as a substrate for culturing various cells including osteoblasts.
In the case of a general fracture, the irregularities are formed as shown in FIG. 2A, and the milling groove 110 of the present invention is also preferably formed correspondingly.
Referring to FIG. 2, the milling groove 110 may be formed along the outer surface of the screw body 100, corresponding to the shape of the fracture line facing the screw body 100.
Accordingly, the milling groove 110 can effectively induce bone formation even when the shape of the fracture site is irregularly provided by providing the bone formation promoting drug along the fracture line.
It would be uncommon for a typical fracture line to have a slope, as shown in Fig. 2A, and to be formed perpendicular to the bone. Accordingly, in accordance with the present invention, the milling groove 110 is also formed so as not to be perpendicular to the threaded body 100 in correspondence with a fractured line formed with an inclination, but is formed to have a slope in the threaded body 100 corresponding to the inclination of the fractured line , The bone fusion promoting tape 200 faces the fracture line as a whole, and bone union can be promoted efficiently.
In one embodiment, the bone-union promotion tape 200 is cut corresponding to the shape of the milling groove 110 and wound along the milling groove 110 to efficiently promote bone union in response to variously formed bone wires .
When the screw main body 100 formed with the milling groove 110 formed according to the present embodiment is inserted into the fracture line portion, the bone fusion promoting tape 200 is wound around the fracture line formed in an inclined shape as shown in FIG. 2B So that the union can be promoted efficiently.
Referring to FIG. 3, the screw 20 for promoting bone fusion includes a screw main body 100 and a bone union promoting tape 200.
The screw main body 100 is inserted into the fracture site of the patient so that the fractured parts are connected to each other, and then the bone formation promoting drug is injected into the screw body 100. The screw body 100 transfers the bone formation promoting drug to the milling groove 110 at the fracture line, And a thread 120 is formed on at least one side to be fastened to the fracture site.
In one embodiment, the screw body 100 may deliver the osteogenic stimulating drug to the bone unification promoting tape 200 through the penetration part 150 and the drug delivery part 160 described later in Fig.
The bone union promoting tape 200 is wound around the milling groove 110 and receives the bone formation promoting drug from the screw body 100 to absorb the bone formation promoting drug.
Unlike the embodiment of FIG. 1 in which the bone fusion promoting tape 200 according to the present embodiment is inserted into the fracture site after the application of the bone formation promoting drug, the bone fusion promoting tape 200 is inserted into the fracture site The bone formation promoting drug is delivered from the screw body 100 to facilitate the union of the fracture site.
In the case of the screw 10 for promoting bone unification described above with reference to FIG. 1, by using the bone unification promoting tape 200 already coated with the bone formation promoting drug, even when there is no supply of the additional bone formation promoting drug, While the screw 20 for promoting bone fusion according to the present embodiment is formed by using the bone fusion promoting tape 200 to which the bone formation promoting drug is not applied and after the insertion of the screw body 100, 100). &Lt; / RTI &gt;
Accordingly, the screw 20 for promoting bone union according to the present embodiment adjusts the amount of the bone formation promoting drug delivered to the bone fusion promotion tape 200 after insertion of the screw body 100 in accordance with the fracture site .
The screw 20 for promoting bone fusion according to the present embodiment is different from the embodiment of FIG. 1 in that, once the osteogenesis promoting drug is applied, the type of the osteogenesis promoting drug can not be changed after insertion into the fracture site , It is possible to change the type of the osteogenesis promoting drug according to the arbitrary judgment of the operator even after the implantation at the fracture site, thereby widening the choice of the operator in the fracture surgery. In addition, Promoting drugs can be prescribed differently.
Referring to FIG. 4, the screw body 100 includes a bone connecting portion 140, a penetrating portion 150, and a drug delivery portion 160.
The bone connecting portion 140 forms a body of the screw body 100. The bone connecting portion 140 is inserted into the fracture portion of the patient so that the fractured portions are connected to each other. The penetrating portion 150 is formed through the center portion in the longitudinal direction, The drug delivery portion 160 is formed through the portion where the promotional tape 200 is wound.
The penetration part 150 is formed in the longitudinal direction along the center of the bone connection part 140 so that the bone formation promoting drug can be injected into the fracture line part. The penetration part 150 penetrates through the drug delivery part 160 And transmits it to the bone union promotion tape 200.
In one embodiment, after the bone connection 140 is inserted into the fracture site, the penetration portion 150 may receive the bone formation promoting drug from the practitioner through a drug insertion means such as a syringe.
The drug delivery portion 160 is formed by passing through the penetration portion 150 from the penetration portion 150 to the portion where the bone fusion promotion tape 200 is wound so as to transmit the bone formation promoting drug inserted along the penetration portion 150 to the bone fusion promotion tape 200 do.
In one embodiment, at least one or more drug delivery portions 160 are formed along the milling grooves 110 to allow the bone formation promoting drug to be entirely delivered to the bone fusion promotion tape 200.
Referring to FIG. 5, the screw 30 for promoting bone fusion includes a screw main body 100 and a bone union promotion tape 200.
The threaded body 100 is threaded through the fractured portion of the patient so that the fractured portions are connected to each other, and the threaded portion 120 is formed on at least one side of the threaded body 100 so as to be fastened to the fractured portion.
The thread 120 according to the present embodiment may be formed while being wholly orbiting along the outer surface of the screw body 100.
The bone union promoting tape 200 is wound around a threaded bone 130 formed by a thread 120, to which a bone formation promoting drug is applied.
The screw 30 for promoting bone fusion with the above-described structure can form the milling groove 110 in the same manner as the other embodiments. However, in the case of this embodiment, as shown in FIG. 5, the milling groove 110 may be formed along the threaded hole 130.
Referring to FIG. 6, the screw body 100 includes a bone connecting portion 140, a penetrating portion 150, and a drug delivery portion 160.
The bone connecting portion 140 forms a body of the screw body 100. The bone connecting portion 140 is inserted into the fracture portion of the patient so that the fractured portions are connected to each other. The penetrating portion 150 is formed through the center portion in the longitudinal direction, The drug delivery portion 160 is formed through the portion where the stimulation tape 200 is wound, and the thread 120 is formed along the outer surface.
The penetration portion 150 is formed in the longitudinal direction along the central portion of the bone connection portion 140 so that the bone formation promoting drug can be injected into the fracture line portion.
The drug delivery portion 160 is formed to pass through the threaded hole 130 from the penetration portion 150 so that the bone formation promoting drug injected along the penetration portion 150 can be transmitted to the bone fusion promotion tape 200.
The drug delivery unit 160 is disposed along the threaded hole 130 from the penetration part 150 so as to transmit the bone formation promoting drug inserted along the penetration part 150 to the bone fusion promotion tape 200 (I.e., a portion where the battery 200 is wound).
The threaded main body 100 having the above-described structure may form a milling groove 110 along the threaded bosses 130 so as to wind the bending fusion promoting tape 200 thereon.
Referring to FIG. 7A, the screw body 100 includes a fastening portion 170.
The fastening part 170 is provided at one side of the bone fusion promotion tape 200 (that is, the starting point at which the bone fusion promotion tape 200 is wound) to prevent the bone fusion promotion tape 200 from being pushed Conclude.
7B is a sectional view of the screw body 100 at a portion where the fastening portion 170 is formed.
Referring to FIG. 7B, the fastening portion 170 includes a fastening groove 171 and a fastening bundle 172.
The fastening groove 171 is formed at the entrance of the threaded boss 130 and is connected to the fastening bundle 172 and is inserted into a space formed therein so as to rotate.
The fastening bundle 172 is formed in correspondence with the shape of the fastening groove 171 and is pivotally connected to the fastening groove 171 so that one side of the fastening groove 171 can be inserted into the fastening groove 171 Connection is established.
In one embodiment, when the fastening bundle 172 is pivotally inserted into the fastening groove 171, the upper surface of the fastening bundle 172 is formed so as to be flat with the threaded bore 130, so that when the threaded body 100 is inserted into the fractured portion, It is possible to prevent unnecessary scratches from occurring due to the exposed portion.
In one embodiment, the bone-union promotion tape 200 is inserted into the insertion groove 173 formed in the lower portion of the fastening bundle 172 and is fastened. As the fastening bundle 172 is rotated and inserted into the fastening groove 171 And can be fastened to the fastening groove 171.
Even when the bending promotion tape 200 is formed of a material having an adhesive force as described above, when the threaded body 100 is inserted into the fractured portion, It may be difficult to completely express the function of the present invention.
Accordingly, the fastening portion 170 according to the present embodiment is configured such that the fastening portion 170 is fastened to the screw main body 100 and the surface to be inserted when the screw main body 100 is inserted into the fractured portion while being inserted It is possible to effectively prevent separation from the screw body 100 even when friction of the screw body 100 occurs.
According to the present invention, by providing a screw for facilitating bone union, which can be manufactured by milling a part of a screw and then using a tape with a bone formation promoting drug wound thereon to promote bone union at a fracture site, The drug-adhered tape can be easily and effectively wound, and the drug-bonded tape can be prevented from being peeled off when the screw is inserted.
The operation of inserting the screw with the bone formation promoting tape is considered to be of great interest in the medical field and the related private institutes are also highly interested in the technology and will have high marketability.
10, 20, 30: Screws for promoting bone fusion
110: Milling groove
120: Threaded
160: drug delivery unit
171: fastening groove
172: fastening bundle
173: insertion groove
200: Bond union promoting tape
A screw main body inserted through the fracture portion of the patient so that the fractured portions are connected to each other, forming a milling groove at a portion where a fracture line, which is a boundary line of the fractured portion, is formed, and forming a thread to be fastened to at least one fracture portion; And
A screw for promoting bone fusion, comprising a bone fusion promoting tape wound around the milling groove, to which an osteogenesis promoting drug is applied.
2. The milling cutter according to claim 1,
Wherein the screw is formed as one or a plurality of screws.
The method of claim 1, wherein the bone-
Wherein a width and a thickness are formed corresponding to a width and a depth of the milling groove, and a bone formation promoting drug is applied to one side of the milling groove and wound on the milling groove.
4. The method of claim 3, wherein the bone-
Wherein the thread is wound in a single layer or two or more layers in the milling groove in a state in which the portion to which the bone formation promoting drug is applied faces upward.
A screw for promoting bone fusion, characterized in that hydroxyapatite is applied as a bone formation promoting agent.
Wherein the threaded portion is formed along an outer surface of the threaded body in correspondence with a shape of a fracture line facing the threaded body.
7. The method of claim 6, wherein the bone-
Wherein the cutter is cut corresponding to the shape of the milling groove and wound along the milling groove.
In order to connect the fractured parts to each other, it is inserted into the fracture site of the patient, and then the bone formation promoting drug is injected and delivered. The milling groove is formed at the part where the fracture line is located, A screw body for forming a thread to be fastened; And
And a bone union promoting tape wound around the milling groove to receive and absorb the bone formation promoting drug from the screw body.
9. The screw according to claim 8,
A bone connecting part inserted into the fracture part of the patient so that the fractured parts are connected to each other;
A penetration portion formed in the longitudinal direction along the central portion of the bone connection portion so as to allow the bone formation promoting drug to be introduced into the fracture line portion; And
And a drug delivery portion formed to penetrate through the penetration portion from the penetration portion to the portion where the bone fusion promotion tape is wound so that the bone formation promoting drug inserted along the penetration portion can be transmitted to the bone fusion promotion tape.
10. The drug delivery device according to claim 9,
And at least one screw is formed along the milling groove.
A screw main body inserted through a fracture portion of the patient so that the fractured portions are connected to each other and forming a screw thread to be fastened to at least one side of the fracture portion; And
A screw for promoting bone fusion, comprising a bone fusion promoting tape to which a bone formation promoting drug is applied and which is wound along a thread formed by the thread.
12. The screwdriver according to claim 11,
And a drug delivery portion formed through the threaded portion from the penetration portion so as to transmit the bone formation promoting drug inserted along the penetration portion to the bone unification promotion tape.
And a milling groove is formed along the threaded hole so as to wind the bony unification promoting tape.
And a fastening part for fastening one side of the bony unification promoting tape to prevent the bending of the bony unification promoting tape when inserted through a fracture part of a patient.
15. The connector according to claim 14,
A coupling groove formed at an inlet portion of the threaded bore; And
And a fastening bundle formed corresponding to the shape of the fastening groove and having one side connected to the fastening groove so as to be inserted into the fastening groove by pivoting after fastening the fastening boding promotion tape. Screws for.
16. The apparatus of claim 15, wherein the fastening bundle comprises:
And when the screw is inserted into the fastening groove, the upper surface is formed to be flat with the screw thread.
16. The method of claim 15, wherein the bone-
Wherein the fastening bolt is inserted into an insertion groove formed in a lower portion of the fastening bundle, and is fastened to the fastening groove when the fastening bundle is rotated and inserted into the fastening groove.
KR1020180002100A 2018-01-08 2018-01-08 Partial Milling Screw with Sticky Tape Containing Bone Anabolic Agent for Augmented Osteosynthesis KR101986447B1 (en)
KR1020180002100A KR101986447B1 (en) 2018-01-08 2018-01-08 Partial Milling Screw with Sticky Tape Containing Bone Anabolic Agent for Augmented Osteosynthesis
KR101986447B1 true KR101986447B1 (en) 2019-06-05
ID=66844680
KR (1) KR101986447B1 (en)
KR100391864B1 (en) * 1995-06-07 2004-04-21 개리 카린 미켈슨 Intra-body spinal fusion
KR20140146533A (en) * 2013-06-17 2014-12-26 가부시키가이샤 지씨 Member for treatment of fracture part
KR101697252B1 (en) 2015-08-04 2017-01-18 전북대학교산학협력단 Fixing plate for bone fracture
KR20170103001A (en) 2015-01-13 2017-09-12 레오스 게엠베하 Bone defect area cap manufacturing method of the coating apparatus, and coating of the bone defect and / or decompression device
2018-01-08 KR KR1020180002100A patent/KR101986447B1/en active IP Right Grant
2019-05-30 GRNT Written decision to grant