Source: http://www.google.com/patents/US7070656?dq=6004266
Timestamp: 2014-03-14 05:06:45
Document Index: 31908868

Matched Legal Cases: ['Application No. 00', 'Application No. 00', 'Application No. 01', 'Application No. 01', 'Application No. 97', 'Application No. 96', 'Application No. 96', 'Application No. 2', 'Application No. 2']

Patent US7070656 - Electrostatic coating - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe invention provides apparatus for electrostatically coating a pharmaceutical tablet core with powdered coating material. The apparatus comprises a first rotary drum (12) on which a core is held in electrical isolation from its surroundings but at a potential differecne to earth by an electrode which...http://www.google.com/patents/US7070656?utm_source=gb-gplus-sharePatent US7070656 - Electrostatic coatingAdvanced Patent SearchPublication numberUS7070656 B2Publication typeGrantApplication numberUS 10/739,943Publication dateJul 4, 2006Filing dateDec 19, 2003Priority dateMay 9, 1995Fee statusPaidAlso published asCA2220506A1, CA2220506C, CN1183715A, CN1183738A, DE69626545D1, DE69634631D1, EP0824344A1, EP0824344B1, EP0869847A1, EP0869847B1, EP1075838A2, EP1075838A3, US6117479, US6406738, US20020034592, US20040177809, WO1996035413A1, WO1996035516A1Publication number10739943, 739943, US 7070656 B2, US 7070656B2, US-B2-7070656, US7070656 B2, US7070656B2InventorsJohn E. Hogan, John N. Stannforth, Linda Reeves, Trevor PageOriginal AssigneePhoqus Pharmaceuticals LimitedExport CitationBiBTeX, EndNote, RefManPatent Citations (98), Non-Patent Citations (22), Referenced by (1), Classifications (37), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetElectrostatic coatingUS 7070656 B2Abstract The invention provides apparatus for electrostatically coating a pharmaceutical tablet core with powdered coating material. The apparatus comprises a first rotary drum (12) on which a core is held in electrical isolation from its surroundings but at a potential differecne to earth by an electrode which contacts the core. The core is carried past a coating station B at which particles of powder having an opposite potential difference to earth are held in a tray (18). The surface of the drum is held at the same potential difference to earth as the powder particles. The powder is attracted to the core, and not to the drum, coating the exposed surface of the core. The drum carries the coated core past a fusing station C at which a heater fuses the powder to form a continuous film coating. The core is then turned and transferred onto a second drum (12′) where the other surface is coated in the same way.
The conventional electrostatic coating technique described above has not been successfully applied to the coating of pharmaceutical tablet cores or other poor electrical conductors, generally those with a resistivity of more than 1010�1015 Ωm. Proposals have been made in which tablet cores are earthed, and a powdered coating material is directed at them through a nozzle which imparts an electrical charge to the powder. The powder coating is then fused to give a uniform coat. This method has been found inefficient, since adequate earthing of the cores has not been achieved, and the charge on the powder accumulates on the surface of the cores, repelling further charged powder. Even if the cores are carried on for example an earthed conveyor belt, the poorly conducting nature of the cores allows charge to build up.
The drums themselves are preferably at least 60 mm in diameter and not less than the minimum tablet diameter in width, rotating at least � r.p.m. The pressure in the vacuum manifold is sufficiently low to hold the tablet against gravity, preferably between 0.2 and 0.6 bar absolute.
39.75% by weight Eudragit RS ammonio-methacrylate co-polymer 39.75% by weight Klucel (hydroxypropylcellulose) 15.0% by weight Titanium dioxide 5.0% by weight Aluminium lake 0.5% by weight Aerosil (colloidal silicon dioxide) The components are premixed under high shear, then wet granulated by mixing under high shear with water (10�15% by weight). The granulated mixture is dried in fluid bed drier at about 45� C. for 20 to 30 minutes to reduce the moisture content to below 3% by weight. The dried granules are milled and micronised to a powder having a size distribution such that 50% by volume of the particles are of a size less than 20 μm, and about 100% by volume are of a size less than 60 μm. The peak size is about 10 μm.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS2698814May 1, 1952Jan 4, 1955Ransburg Electro Coating CorpElectrostatic coating apparatus and methodUS3764538Mar 10, 1971Oct 9, 1973Addressograph MultigraphElectroscopic printing powderUS3900000Nov 28, 1973Aug 19, 1975Thomas J GallenApparatus for spray coating articlesUS4029757Dec 15, 1975Jun 14, 1977Hoffmann-La Roche Inc.Manufacture of pharmaceutical unit dosage formsUS4128445Aug 18, 1977Dec 5, 1978Hoffmann-La Roche Inc.Manufacture of pharmaceutical unit dosage formsUS4176175Jun 6, 1977Nov 27, 1979Shin-Etsu Chemical Co., Ltd.Sugar-coated solid dosage formsUS4197289Aug 15, 1978Apr 8, 1980Hoffmann-La Roche Inc.Novel dosage formsUS4201834Dec 5, 1978May 6, 1980Celanese CorporationPowder composition and method of preparationUS4322449Jan 3, 1980Mar 30, 1982Boehringer Ingelheim GmbhPharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereofUS4349531Oct 4, 1979Sep 14, 1982Hoffmann-La Roche Inc.Novel dosage formUS4359483Feb 10, 1981Nov 16, 1982Japan Atomic Energy Research InstituteProcess for producing a multi-layered slow release compositeUS4427712Aug 27, 1979Jan 24, 1984Continental Can Company, Inc.Electrodynamic coating processUS4433076Dec 8, 1981Feb 21, 1984Rohm GmbhCoating agent for medicaments and methods for making and using the sameUS4454125Apr 22, 1982Jun 12, 1984Demopoulos Harry BDry powder formulations having improved flow and compressibility characteristics, and method for the preparation thereofUS4482387Dec 2, 1983Nov 13, 1984E. R. Squibb & Sons, Inc.Powdered wax, tablet coated therewith and methodUS4547571Oct 5, 1984Oct 15, 1985Kohjin Co., Ltd.Process for preparing carboxymethyl ethyl cellulose suitable for enteric coatingUS4548825Oct 3, 1983Oct 22, 1985Boehringer Ingelheim GmbhMethod for ink-jet printing on uncoated tablets or uncoated tablet coresUS4704295Aug 30, 1985Nov 3, 1987Colorcon, Inc.Enteric film-coating compositionsUS4786505Apr 20, 1987Nov 22, 1988Aktiebolaget HasslePharmaceutical preparation for oral useUS4800079Aug 10, 1987Jan 24, 1989Ethypharm SaMedicine based on fenofibrate, and a method of preparing itUS4810501Jun 17, 1986Mar 7, 1989Warner-Lambert CompanySustained release pharmaceutical preparationsUS4828840Jun 26, 1987May 9, 1989Shionogi & Co., Ltd.Sustained-release formulation and production thereofUS4925670Apr 24, 1989May 15, 1990Desitin Arzneimittel GmbhAdministration and dosage form for drug active agents, reagents or the like and process for the preparation thereofUS4935246Jun 29, 1988Jun 19, 1990Hoechst AktiengesellschaftProcess for the coating of granulesUS4994273Jul 20, 1989Feb 19, 1991Merck & Co., Inc.Solubility modulated drug delivery deviceUS5011694Aug 1, 1989Apr 30, 1991Rohm GmbhPharmaceutical dosage unit forms with delayed releaseUS5076706Oct 30, 1990Dec 31, 1991Koshin Denki Kogyo Co., Ltd.Method of mixing of dispersing particles with an electrode assemblyUS5206030Feb 26, 1990Apr 27, 1993Fmc CorporationFilm-forming composition and use for coating pharmaceuticals, foods and the likeUS5320796Apr 29, 1993Jun 14, 1994Dow Corning Toray Silicone Co., Ltd.Method for the preparation of powder mixturesUS5411730Jul 20, 1993May 2, 1995Research Corporation Technologies, Inc.Magnetic microparticlesUS5436026Jan 12, 1993Jul 25, 1995Mcneil-Ppc, Inc.Discharge and transfer system for apparatus for gelatin coating tabletsUS5470603Feb 21, 1992Nov 28, 1995Hoechst Uk LimitedElectrostatic coating of substrates of medicinal productsUS5474786Oct 6, 1994Dec 12, 1995Ortho Pharmaceutical CorporationMultilayered controlled release pharmaceutical dosage formUS5540995Oct 5, 1994Jul 30, 1996Asahi Kogaku Kogyo Kabushiki KaishaGranular polymer composite and production process thereof as well as diagnostic agentUS5615614Apr 3, 1995Apr 1, 1997Van Pelt Equipment CorporationThermography process and apparatusUS5699649Jul 2, 1996Dec 23, 1997Abrams; Andrew L.Metering and packaging device for dry powdersUS5714007Jun 6, 1995Feb 3, 1998David Sarnoff Research Center, Inc.Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrateUS5792513Mar 7, 1997Aug 11, 1998Koslow Technologies CorporationContinuous solid state web coating processUS5846595Apr 9, 1996Dec 8, 1998Sarnoff CorporationMethod of making pharmaceutical using electrostatic chuckUS5857456Jun 10, 1996Jan 12, 1999Sarnoff CorporationInhaler apparatus with an electronic means for enhanced release of dry powdersUS6026809Jan 25, 1996Feb 22, 2000Microdose Technologies, Inc.Inhalation deviceUS6074688Oct 18, 1996Jun 13, 2000Delsys Pharmaceautical CorporationMethod for electrostatically depositing a medicament powder upon predefined regions of a substrateUS6117479Nov 10, 1997Sep 12, 2000Phoqus LimitedElectrostatic coatingUS6294024Oct 20, 1998Sep 25, 2001Delsys Pharmaceutical CorporationElectrostatic chucks and a particle deposition apparatus thereforUS6298847Dec 11, 1998Oct 9, 2001Delsys Pharmaceutical Corp.Inhaler apparatus with modified surfaces for enhanced release of dry powdersUS6319541Dec 30, 1999Nov 20, 2001Delsys Pharmaceutical CorporationMethod and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrateUS6406738Nov 10, 1997Jun 18, 2002Phoqus LimitedPowder coating composition for electrostatic coating of pharmaceutical substratesUS6783768May 13, 1999Aug 31, 2004Phoqus Pharmaceuticals LimitedMethod and apparatus for the coating of substrates for pharmaceutical useUSRE31764Oct 12, 1982Dec 11, 1984Boehringer Ingelheim GmbhPharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereofDE52460C Title not availableDE2247701A1Sep 28, 1972Apr 11, 1974Heinz Dr HaaseVerfahren und vorrichtung zum aufbringen fester oder fluessiger partikel auf oberflaechen mittels elektrischer feldkraefteDE3049179A1Dec 24, 1980Jul 29, 1982Roehm GmbhBindemittel fuer arzneimittelueberzuege.DE3106984A1Feb 25, 1981Feb 18, 1982Japan Atomic Energy Res InstVerfahren zur herstellung eines mehrschichtigen verbundstoffs mit langzeit-freigabeEP0011268A1Nov 12, 1979May 28, 1980Dr. Karl Thomae GmbHMethod of making solid medicaments with active agents applied in form of dropsEP0011268B1Nov 12, 1979Dec 29, 1982Dr. Karl Thomae GmbHMethod of making solid medicaments with active agents applied in form of dropsEP0020181A1Jun 4, 1980Dec 10, 1980Xerox CorporationProcess for preparing coated carrier particles for electrostatographic developersEP0063014A2Apr 1, 1982Oct 20, 1982Sankyo Company LimitedA method of preparing coated solid preparationsEP0107557A1Oct 6, 1983May 2, 1984Societe D'etudes Scientifiques Et Industrielles De L'ile-De-FranceGalenic of sulpiride, process for its preparation and medicament comprising itEP0164959A2May 30, 1985Dec 18, 1985Sterwin Ag.Pharmaceutical composition in sustained release unit dose form and process for its preparationEP0220670A2Oct 22, 1986May 6, 1987Eisai Co., Ltd.Multilayer granuleEP0259749A1Sep 1, 1987Mar 16, 1988Desitin Arzneimittel GmbHDosage and administration forms for medicines, reagents or the like, and process for their preparationEP0277741A1Jan 25, 1988Aug 10, 1988Takeda Chemical Industries, Ltd.Spherical granules having core and their productionEP0307642A2Aug 18, 1988Mar 22, 1989BEHR INDUSTRIEANLAGEN GMBH &amp; CO.Work piece support for electrostatic coatingEP0452862A2Apr 16, 1991Oct 23, 1991Asahi Kasei Kogyo Kabushiki KaishaSpherical seed cores, spherical granules and process for production thereofEP0459048A1Jun 1, 1990Dec 4, 1991Courtaulds Coatings (Holdings) LimitedColoured powder coating compositionsEP0536791A1Oct 9, 1992Apr 14, 1993Nippon Paint Co., Ltd.Powdered paintEP0543541A1Nov 6, 1992May 26, 1993Schering CorporationControlled release flutamide compositionEP0551700A1Jan 17, 1992Jul 21, 1993BPSI Holdings, Inc.Film coatings and film coating compositions based on cellulosic polymers and lactoseEP0567201A2Apr 16, 1987Oct 27, 1993Aktiebolaget H�ssleVehicles for oral administration of a specific pharmaceutically active acid labile substanceEP0607009A1Jan 11, 1994Jul 20, 1994McNEIL-PPC, INC.Discharge and transfer system for apparatus for gelatin coating tabletsEP0661091A1Dec 9, 1994Jul 5, 1995OTEFAL S.p.A.Process for the production of powders with controlled particle sizes and powdery product so obtainedEP0678561A2Apr 15, 1995Oct 25, 1995BASF AktiengesellschaftMetal pigments twice passivated in a gaseous phaseEP0678564A2Apr 21, 1995Oct 25, 1995Tomoegawa Paper Co. Ltd.Powder coatingFR24084E Title not availableGB1075404A Title not availableGB1108837A Title not availableGB1561100A Title not availableGB2056885A Title not availableGB2065691A Title not availableGB2129301A Title not availableGB2179254A Title not availableGB2203336A Title not availableGB2241889A Title not availableGB2253164A Title not availableGB2253164B Title not availableWO1991016041A1Apr 24, 1991Oct 27, 1991Smith Kline French LabPharmaceutical compositionsWO1992011002A1Dec 12, 1991Jul 9, 1992Warner Jenkinson CompanyWet powder film-forming compositionsWO1992014451A1Feb 21, 1992Sep 3, 1992Hoechst Uk LtdImprovements in or relating to electrostatic coating of substrates of medicinal productsWO1994005263A1Aug 27, 1993Mar 17, 1994Conde Valentin Florent VictorBeads having a core coated with an antifungal and a polymerWO1994011446A1Nov 5, 1993May 26, 1994Courtaulds Coatings HoldingsPowder coating compositions and their useWO1996002236A1Jul 18, 1995Feb 1, 1996Borody Thomas JImproved combination dose unitWO1996011707A1Oct 12, 1995Apr 25, 1996Oregon StateRenibacterium salmoninarum vaccine and method for its preparationWO1996035413A1May 8, 1996Nov 14, 1996Berwind Pharma ServicePowder coating composition for electrostatic coating of pharmaceutical substratesWO1996039256A1Jun 6, 1996Dec 12, 1996Sarnoff David Res CenterApparatus for electrostatically depositing and retaining materials upon a substrateWO1996039257A1Jun 6, 1996Dec 12, 1996Sarnoff David Res CenterElectrostatically depositing a medicament powderWO1997004827A1Jul 25, 1996Feb 13, 1997Sarnoff David Res CenterInhaler apparatus using a tribo-electric charging techniqueWO1997037775A1Apr 9, 1997Oct 16, 1997Sarnoff CorpAcoustic dispenserWO1997037803A1Apr 9, 1997Oct 16, 1997Sarnoff CorpChucks and methods for positioning multiple objects on a substrateNon-Patent CitationsReference1Bocchi, G.J., "Powder Coating The Complete Finishers Handbook"; Published by The Powder Coating Institute; pp. 1-7; (1994).2Chemical Abstracts, vol. 120, No. 20, (1994), Grosvenor M.P. Diss. Abstr. Int., vol. 53, No. 7 (1991) Bath, p. 3492 Grovenor M.P.3EP Combined Search Report and Examination Report under Sections 17 and 18(3), Application No. GB 0103413.1, dated Mar. 23, 2001, 2 pgs.4EP Combined Search Report and Examination Report under Sections 17 and 18(3), Application No. GB 9828580.2, dated Feb. 4, 1999, 2 pgs.5EP Communication pursuant to Article 96(2) EPC, Application No. 00 117 256.8 -2108, dated Apr. 8, 2005, 3 pgs.6EP Communication pursuant to Article 96(2) EPC, Application No. 00 117 256.8-2108, dated May 5, 2003, 3 pgs.7EP Communication pursuant to Article 96(2) EPC, Application No. 01 948 995.4-1214, dated Dec. 6, 2004, 3 pgs.8EP Communication pursuant to Article 96(2) EPC, Application No. 01 948 995.4-1214, dated Jun. 26, 2003, 3 pgs.9EP Communication pursuant to Article 96(2) EPC, Application No. 97 912 341.1-2114, dated Jan. 24, 2002, 3 pgs.10EP Examination Report under Section 18(3), Application No. GB 0217155.1, dated Jun. 5 2003, 3 pgs.11EP Examination Report under section 18(3), Application No. GB 9911055.3, dated Mar. 28, 2000, 3 pgs.12EP Official Action, Application No. 96 913 629 0-2114, dated Jan. 22, 2001, 3 pgs.13EP Official Action, Application No. 96 913 629 0-2114, dated Oct. 8, 1999, 2 pgs.14Eschborn/Tanus: Pharmazeutische Stoffliste 13. Auflage; List of Pharmaceutical Substances 13<SUP>th </SUP>Edition; Bearbeitet und herausgegeben von Prepared and published by Pharma-Daten-Service; pp. 230-231, (Sep. 2003).15Examination Report under Section 18(3), Application No. GB 9723708.5 dated May 27, 1998, 4 pgs.16Gowling Lafleur Henderson LLP, Canadian Intellectual Property Office Official Action, Application No. 2,220,506, dated Feb. 17, 2005, 4 pgs.17Gowling Lafleur Henderson LLP, Canadian Intellectual Property Office Official Action, Application No. 2,279,841, dated Dec. 13, 2004, 3 pgs.18Kirk-Othmer, Encyclopedia of Chemical Technology, Third Edition, vol. 19; "Powder coatings to Recycling", 4 pgs.19PCT International Preliminary Examination Report, International Application No. PCT/GB97/03121, dated Feb. 12, 1999.20PCT Notification o f Transmittal of the International Preliminary Examination Report, Int'l Application No. PCT/GB01/00425, dated Jun. 6, 2002, 17 pgs.21PCT/GB96/01101, International Preliminary Examination Report, Aug. 18, 1997, 11 pgs.22PCT/GB96/01101, International Search Report, Sep. 5, 1996, 4 pgs.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7732020Mar 31, 2005Jun 8, 2010Glaxo Group LimitedMethod and apparatus for the application of powder material to substratesClassifications U.S. Classification118/630, 118/621, 118/625, 118/308International ClassificationB05D1/40, B05D1/06, A61K9/24, A61J3/06, B05D7/00, B05B5/025, A61J3/00, B05C19/00, B05D1/04, B05B5/08, A61K9/28Cooperative ClassificationA61K9/2893, A61K9/209, B05B5/087, A61K9/2846, A61K9/2866, B05B5/082, A61K9/2853, B05B5/08, B05B5/081, A61J3/005, B05D1/045European ClassificationA61K9/28H6F2, A61K9/20K4B, B05B5/08, A61K9/28H6B2, B05B5/08C, B05B5/08D, B05B5/08G, A61K9/28P, B05D1/04C, A61K9/28H6D, A61J3/00CLegal EventsDateCodeEventDescriptionAug 17, 2010ASAssignmentOwner name: GLAXO GROUP LIMITED, UNITED KINGDOMFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PHOQUS PHARMACEUTICALS (UK) LIMITED;REEL/FRAME:024838/0496Effective date: 20090923Dec 22, 2009FPAYFee paymentYear of fee payment: 4Apr 3, 2007ASAssignmentOwner name: OXFORD FINANCE CORPORATION, VIRGINIAFree format text: PATENT SECURITY AGREEMENT AND COLLATERAL ASSIGNMENT;ASSIGNOR:PHOQUS GROUP PLC;REEL/FRAME:019102/0239Effective date: 20070402Feb 9, 2005ASAssignmentOwner name: PHOQUS PHARMACEUTICALS LIMITED, ENGLANDFree format text: CHANGE OF NAME;ASSIGNOR:PHOQUS LIMITED;REEL/FRAME:016243/0997Effective date: 20030522Feb 9, 2004ASAssignmentOwner name: PHOQUS PHARMACEUTICALS LIMITED, UNITED KINGDOMFree format text: DEED OF RELEASE OF DEBENTURES;ASSIGNOR:ETV CAPITAL SA;REEL/FRAME:016808/0086Effective date: 20040728RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google