Source: http://www.google.com/patents/US8232536?ie=ISO-8859-1
Timestamp: 2015-01-31 04:55:36
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Matched Legal Cases: ['art 10', 'art 20', 'arts 30', 'art 10', 'arts 30', 'art 20', 'art 10', 'arts 30', 'art 20', 'art 10', 'arts 30', 'art 20', 'arts 30', 'art 20', 'art 13', 'art 89', 'art 13', 'art 89']

Patent US8232536 - Particle beam irradiation system and method for controlling the particle ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThere is provided a particle beam irradiation system so as to provide the dose distribution having more accuracy. An irradiation control part comprises an energy setting controller that sets the energy of a charged particle beam, a beam scanning controller that controls a beam scanner, and a beam diameter...http://www.google.com/patents/US8232536?utm_source=gb-gplus-sharePatent US8232536 - Particle beam irradiation system and method for controlling the particle beam irradiation systemAdvanced Patent SearchPublication numberUS8232536 B2Publication typeGrantApplication numberUS 13/058,963Publication dateJul 31, 2012Filing dateMay 27, 2010Priority dateMay 27, 2010Also published asCN102844820A, EP2579265A1, EP2579265A4, US20120056098, WO2011148486A1Publication number058963, 13058963, US 8232536 B2, US 8232536B2, US-B2-8232536, US8232536 B2, US8232536B2InventorsHisashi HaradaOriginal AssigneeMitsubishi Electric CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (38), Non-Patent Citations (1), Referenced by (3), Classifications (25), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetParticle beam irradiation system and method for controlling the particle beam irradiation systemUS 8232536 B2Abstract There is provided a particle beam irradiation system so as to provide the dose distribution having more accuracy. An irradiation control part comprises an energy setting controller that sets the energy of a charged particle beam, a beam scanning controller that controls a beam scanner, and a beam diameter changer to control a beam diameter changer, wherein the irradiation control part sets a beam diameter of the charged particle beam to be a first beam diameter by the beam diameter changer, the charged particle beam is scanned step-wise by the beam scanning controller so as to irradiate the charged particle beam on a predetermined region of the irradiation target, after that, the beam diameter of the charged particle beam is set by the beam diameter controller to be a second beam diameter that is different from the first beam diameter, and the charged particle beam is scanned step-wise by the beam scan controller so as to control the charged particle beam to irradiate on a region that is overlapped with at least a part of the predetermined part of the irradiation target.
a particle beam generation part;
a particle beam irradiation part where a charged particle beam that is generated in the particle beam generation part is irradiated on an irradiation target and;
an irradiation control part that controls the charged particle beam to be irradiated;
wherein the particle beam irradiation part comprises:
a beam scanner that scans the charged particle beam laterally in two dimensions that is perpendicular to the irradiation direction of the charged particle beam; and a beam diameter changer that changes the beam diameter of the charged particle beam;
wherein the irradiation control part comprises: an energy setting controller that sets the energy of the charged particle beam;
a beam scanning controller that controls the beam scanner; and
a beam diameter controller that controls the beam diameter changer;
wherein the irradiation control part sets the beam diameter of the charged particle beam by the beam diameter controller to be a first beam diameter, the charged particle beam is scanned step-wise by the beam scanning controller so as to irradiate the charged particle beam on a predetermined region of the irradiation target, after that, the beam diameter of the charged particle beam is set by the beam diameter controller to be a second diameter that is different from the first beam diameter, and the charged particle beam is scanned step-wise by the beam scan controller so as to control the charged particle beam to irradiate on a region that is overlapped with at least a part of the predetermined part of the irradiation target.
2. The particle beam irradiation system according to claim 1, wherein the region irradiated by the beam having the smaller diameter between the first beam and the second beam is narrower than the region irradiated with the beam having the larger diameter between the first beam and the second beam.
wherein the irradiation control part controls the irradiation with the small beam diameter corresponding to the output signal transmitted from the displacement detector.
4. The particle beam irradiation system according to claim 3,
wherein the irradiation control part controls the irradiation in which the beam having the larger beam diameter is irradiated under the condition that irradiation permission condition for irradiation with the beam having the larger beam diameter is less strict compared to the irradiation permission condition for irradiation with the beam having the smaller diameter corresponding to the output signal transmitted from the displacement detector.
5. The particle beam irradiation system according to claim 2, wherein the irradiation control part controls to irradiate with a beam having small beam diameter plural times at the same irradiation region.
wherein a beam diameter of the charged particle beam is set to be a first beam diameter,
the charged particle beam is scanned step-wise so as to irradiate the charged particle beam on a predetermined region of the irradiation target, after that, the beam diameter of the charged particle beam is set to be a second diameter that is different from the first diameter, and the charged particle beam is scanned step-wise so as to control the charged particle beam to irradiate on a region that is overlapped with at least a part of the predetermined part of the irradiation target.
7. The method for controlling the particle beam irradiation system according to claim 6, wherein the region irradiated by the beam having the smaller diameter between the first beam and the second beam is narrower than the region irradiated with the beam having the larger diameter between the first beam and the second beam.
9. A method for controlling the particle beam irradiation system according to claim 7, wherein the irradiation with the small beam diameter is controlled to perform plural times at the same irradiation region. Description
FIG. 1 is a bird's-eye view schematically illustrating the whole configuration of the particle beam irradiation system according to Embodiment 1 of the present invention, and FIG. 2 is a block diagram schematically illustrating the configuration of the particle beam irradiation system according to Embodiment 1 of the present invention which includes a controlling device in addition to the whole configuration shown in a bird's-eye view of FIG. 1. As shown in FIGS. 1 and 2, Embodiment 1 of the particle beam irradiation system includes a particle beam generation part 10, a particle beam transport part 20, and two particle beam irradiation parts 30A and 30B. For reasons of application of radiation safety management and the like, the particle beam generation part 10 and the particle beam irradiation parts 30A and 30B are installed in individual shielded rooms. The particle beam transport part 20 connects the particle beam generation part 10 to the respective particle beam irradiation parts 30A and 30B. The particle beam transport part 20 includes particle beam transport passages 21 and 22 to transport the particle beam generated in the particle beam generation part 10 to the respective particle beam irradiation parts 30A and 30B. The particle beam transport part 20 has a deflection electromagnet 50 for changing the direction of a particle beam and is constructed so as for a particle beam to pass through vacuum ducts. The particle beam irradiation parts 30A and 30B irradiate the particle beam PB to target regions TV of patients.
Next, Embodiment 2 of the present invention will be described. In Embodiment 2, respiration measurement of a patient or position detection of an irradiation target is performed, and based on the respiration measurement or the position detection of the irradiation target, a respiration judgment of the patient is performed, and particle beams are irradiated in synchronization with the respiration phase. Since a position of irradiation target is changed by respiration of a patient, an irradiation position of the particle beam is changed. Consequently, the irradiation accuracy is decreased. Particularly, since a part of the deepest layer is a border layer between normal cells and a diseased part, and the dose irradiated with the deepest layer is high, the irradiation dose given to normal cells may increase due to deterioration of the irradiation accuracy. Therefore, particularly, high irradiation accuracy is required in performing irradiation in the deepest layer. Consequently, in the particle beam irradiation system according to Embodiment 2, irradiation with an irradiation spot having a small diameter in Embodiment 1 is performed in synchronization with the respiration phase so as to irradiate at the respiration phase in which change of the position of an irradiation target is small.
FIG. 8 shows a method of controlling the particle beam irradiation system according to Embodiment 3. In Embodiment 1, the irradiation with the irradiation spot S2 having a small beam diameter is performed once at each position in the deepest layer. However, in Embodiment 3, the irradiation with the irradiation spot S2 is performed at each spot position in the deepest layer plural times.
Since in Embodiments 1 to 3, large dose distribution is applied to the deepest part, large dose is applied precisely to the deepest part by a beam with the irradiation spot S2 having a small beam diameter. However, in some cases of diseased part, large dose distribution is required to apply to a part other than the deepest part. For example, cancer has a region in which a cell having high radiation resistance exists at a center of tumor of Za in the Zi layer as shown in FIG. 10A. FIG. 10B is a diagram showing the irradiation with the irradiation spot S2 having a small spot diameter that is applied to a layer indicated by Zi layer in FIG. 10A. As shown in FIG. 10B, not only the peripheral part that is the deepest part, but also the region of Za, irradiation with the irradiation spot S2 having a small spot diameter is applied so as to form the irradiation dose distribution with large dose in the region of Za.
In Embodiment 1, the beam diameter is changed by four-pole magnet; however, the beam diameter may be changed by other means. FIG. 11A shows another example of beam diameter changer that changes the beam diameter. Numeral 60 indicates a beam diameter changer comprising a scatter 61 and a collimator 62. When a beam having a small diameter PB1 is incident on the scatter 61, the beam is scattered forward to be a diverging beam. When the diverging beam is passed through the collimator 62, the beam diameter of the beam PB1 is changed to the beam diameter of the beam PB2, which is larger than PB1. The parameter of the scatter 61 and the collimator 62 are set for the beam diameter of the beam PB1 in a state where the beam is not passed through the beam diameter changer 60 to be the small diameter S2 in Embodiments 1 to 3; and the parameter of the scatter 61 and the collimator 62 those are set for the beam diameter which is passed through the beam diameter changer 60 to be S1. The beam diameter changer 60 may provide on the irradiation nozzle 31 or on the particle beam transport part 20, and the beam diameter changer 60 is provided movably on the passage of beam. By moving the beam diameter changer 60, the beam is controlled to pass through the beam diameter changer 60 so as to be the beam diameter S1, and the beam is controlled not to pass through the beam diameter changer 60 so as to be the beam diameter S2. When a beam having a large beam diameter in Embodiments 1 to 3 is irradiated, as shown in FIG. 11A, a beam that is passed through the beam diameter changer 60 is irradiated. When a beam having a small beam diameter is irradiated, as shown in FIG. 11B, the beam diameter changer 60 is moved as shown by the arrow, and a beam having the state of PB1 is irradiated. The movement of the beam diameter changer 60 is controlled by the signal that is transmitted from the beam diameter controller 15 of the irradiation control part 13.
In Embodiment 1, the particle beam energy is changed in a particle beam generation part, however, an energy changer may be provided in the middle of the passage of beam so as to change the energy. FIG. 12 shows the configuration of one example of an energy changer. The energy changer 80 comprises a range shifter 81 having the thickness that changes in stepwise to the width direction (X direction); deflection electromagnets 82 and 83 that constitute a pair of deflection electromagnets that are provided at the upstream for changing the position of the charged particle beam PB that passes through the range shifter 81; a first deflection electromagnet power source 84 that excites the pair of deflection electromagnets that are provided at the upstream; a deflection electromagnet 85 and 86 that constitute a pair of deflection electromagnets that are provided at the downstream for returning the charged particle beam PB that passed through the range shifter 81 to the original trajectory; a second deflection electromagnet power source 87 that excites the pair of deflection electromagnets that are provided at the downstream; and a deflection control part 89 that calculates the moving amount of the charged particle beam in the trajectory caused by the pair of deflection electromagnets that are provided at the upstream, based on the energy command value that is input from the energy setting controller 14 of the irradiation control part 13, to transmit the exciting current value to the first deflection electromagnet power source 83. The deflecting control part 89 also controls the second deflection electromagnet power source 87.
The charged particle beam PB is incident on the pair of deflection electromagnets that are provided on the upstream on the beam axis 90 (Z axis). The trajectory of the charged particle beam PB is moved to the horizontal direction (X direction) on the plane of paper of FIG. 12. The deflection electromagnet 82 is a deflection electromagnet for changing the trajectory and the deflection electromagnet 83 is a deflection electromagnet for parallelizing the trajectory. The deflection electromagnet 82 for changing the trajectory deflects the trajectory of incident charged particle beam PB to be inclined at a predetermined angle θ to the Z axis. The deflection electromagnet for parallelizing the trajectory 83 deflects the charged particle beam PB that is inclined at a predetermined angle to the Z axis by the deflection electromagnet for changing the trajectory 82 to be parallel to the Z axis. On the downstream of the range shifter 81, the charged particle beam PB is returned to the beam axis 90 (Z axis) by the deflection electromagnet for changing the trajectory 85 and a deflection electromagnet for parallelizing the trajectory 86. The deflection electromagnet for changing the trajectory 85 deflects the charged particle beam PB to be inclined at a predetermined angle to the Z axis. The deflection electromagnet for parallelizing the trajectory 86 deflects the trajectory that is inclined to the Z axis by the deflection electromagnet for deflecting the trajectory 85 to the trajectory on the Z axis.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4537507 *Oct 18, 1982Aug 27, 1985Spectron Development Laboratories, Inc.For measuring or sensing parametersUS4754147 *Apr 11, 1986Jun 28, 1988Michigan State UniversityVariable radiation collimatorUS4868843 *Jul 10, 1987Sep 19, 1989Varian Associates, Inc.Multileaf collimator and compensator for radiotherapy machinesUS6218675 *Aug 19, 1998Apr 17, 2001Hitachi, Ltd.Charged particle beam irradiation apparatusUS6433336 *Dec 20, 1999Aug 13, 2002Ion Beam Applications S.A.Device for varying the energy of a particle beam extracted from an acceleratorUS6472834 *Feb 26, 2001Oct 29, 2002Hitachi, Ltd.Accelerator and medical system and operating method of the sameUS6641705 *Mar 27, 2001Nov 4, 2003Fei CompanyApparatus and method for reducing differential sputter ratesUS6825476 *Jan 24, 2001Nov 30, 2004ICT Integrated Circuit Testing Gesellschaft f�r Halbleiterpr�ftechnik mbHColumn for a charged particle beam deviceUS7102144May 11, 2004Sep 5, 2006Hitachi, Ltd.Particle beam irradiation apparatus, treatment planning unit, and particle beam irradiation methodUS7122978 *Apr 19, 2005Oct 17, 2006Mitsubishi Denki Kabushiki KaishaCharged-particle beam accelerator, particle beam radiation therapy system using the charged-particle beam accelerator, and method of operating the particle beam radiation therapy systemUS7157703 *Aug 29, 2003Jan 2, 2007Ebara CorporationElectron beam systemUS7525104 *Feb 4, 2005Apr 28, 2009Mitsubishi Denki Kabushiki KaishaParticle beam irradiation method and particle beam irradiation apparatus used for the sameUS7792249 *Dec 18, 2008Sep 7, 2010Oraya Therapeutics, Inc.Methods and devices for detecting, controlling, and predicting radiation deliveryUS8129699 *May 12, 2009Mar 6, 2012Vladimir BalakinMulti-field charged particle cancer therapy method and apparatus coordinated with patient respirationUS20010053605 *Mar 27, 2001Dec 20, 2001Michael PhaneufApparatus and method for reducing differential sputter ratesUS20030011760 *Jul 10, 2002Jan 16, 2003Mehdi Vaez-IravaniSystems and methods for simultaneous or sequential multi-perspective specimen defect inspectionUS20030075686 *Jan 24, 2001Apr 24, 2003Pavel AdamecColumn for a charged particle beam deviceUS20030213922 *May 14, 2003Nov 20, 2003The Board of Trustees of the University of Illinois, University of IllinoisNanolithography molecular beam machineUS20040159787 *Aug 29, 2003Aug 19, 2004Mamoru NakasujiElectron beam systemUS20080067401Feb 4, 2005Mar 20, 2008Mitsubishi Denki Kabushiki KaishaParticle Beam Irradiation Method and Particle Beam Irradiation Apparatus Used for the SameUS20090161826 *Oct 30, 2008Jun 25, 2009Oraya Therapeutics, Inc.Methods and devices for orthovoltage ocular radiotherapy and treatment planningUS20100091948 *Dec 12, 2009Apr 15, 2010Vladimir BalakinPatient immobilization and repositioning method and apparatus used in conjunction with charged particle cancer therapyUS20100127184 *Jan 14, 2010May 27, 2010Dr. Vladimir BalakinCharged particle cancer therapy dose distribution method and apparatusUS20100181479 *Jun 25, 2009Jul 22, 2010Rainer KnippelmeyerParticle-optical systems and arrangements and particle-optical components for such systems and arrangementsUS20100213384 *Oct 31, 2005Aug 26, 2010National Institute Of Radiological SciencesIrradiation Field Forming DeviceUS20100266100 *May 22, 2010Oct 21, 2010Dr. Vladimir BalakinCharged particle cancer therapy beam path control method and apparatusUS20110118529 *Jan 5, 2011May 19, 2011Vladimir BalakinMulti-axis / multi-field charged particle cancer therapy method and apparatusUS20110118531 *May 21, 2009May 19, 2011Vladimir Yegorovich BalakinMulti-axis charged particle cancer therapy method and apparatusUS20110147608 *Feb 23, 2011Jun 23, 2011Vladimir BalakinCharged particle cancer therapy imaging method and apparatusUS20110150180 *May 21, 2009Jun 23, 2011Vladimir Yegorovich BalakinX-ray method and apparatus used in conjunction with a charged particle cancer therapy systemUS20110182410 *May 21, 2009Jul 28, 2011Vladimir Yegorovich BalakinCharged particle cancer therapy beam path control method and apparatusUS20110196223 *Apr 14, 2011Aug 11, 2011Dr. Vladimir BalakinProton tomography apparatus and method of operation thereforUS20110233423 *May 21, 2009Sep 29, 2011Vladimir Yegorovich BalakinMulti-field charged particle cancer therapy method and apparatusUS20110313232 *Mar 4, 2009Dec 22, 2011Vladimir Egorovich BalakinMulti-Field Charged Particle Cancer Therapy Method and ApparatusUS20120056098 *May 27, 2010Mar 8, 2012Mitsubishi Electric CorporationParticle beam irradiation system and method for controlling the particle beam irradiation systemJP2001212253A Title not availableJP2006346120A Title not availableWO2006082651A1Feb 4, 2005Aug 10, 2006Hisashi HaradaParticle beam irradiation method and particle beam irradiator for use therein* Cited by examinerNon-Patent CitationsReference1International Search Report (PCT/ISA/210) for PCT/JP2010/058979 dated Jun. 29, 2010.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS8604444 *Aug 20, 2010Dec 10, 2013Mitsubishi Electric CorporationParticle beam irradiation apparatus and particle beam therapy systemUS20110006214 *Jun 28, 2010Jan 13, 2011Boenig Marc-OliverAccelerator system and method for setting particle energyUS20130075622 *Aug 20, 2010Mar 28, 2013Mitsubishi Electric CorporationParticle beam irradiation apparatus and particle beam therapy system* Cited by examinerClassifications U.S. Classification250/493.1, 378/65, 250/396.00R, 378/137, 250/492.1, 378/156, 250/491.1, 250/492.22, 250/492.2, 600/2, 600/1International ClassificationH01J37/09, G21K5/04Cooperative ClassificationA61N2005/1087, A61N5/1042, A61N2005/1074, A61N5/1079, A61N5/1065, A61N5/1043, A61N5/1049, G21K1/093European ClassificationA61N5/10J4, A61N5/10D2, G21K1/093, A61N5/10DLegal EventsDateCodeEventDescriptionFeb 14, 2011ASAssignmentOwner name: MITSUBISHI ELECTRIC CORPORATION, JAPANEffective date: 20110117Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HARADA, HISASHI;REEL/FRAME:025804/0379RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services