Source: http://www.google.com/patents/US20050197695?dq=6825444
Timestamp: 2016-05-01 15:22:19
Document Index: 540690730

Matched Legal Cases: ['arts 50', 'arts 50', 'arts 52', 'arts 52', 'art 32', 'arts 51', 'arts 51', 'art 5', 'art 32']

Patent US20050197695 - Minimally-invasive cardiac-valve prosthesis - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA cardiac-valve prosthesis is adapted for percutaneous implantation. The prosthesis includes an armature adapted for deployment in a radially expanded implantation position, the armature including a support portion and an anchor portion, which are substantially axially coextensive with respect to one...http://www.google.com/patents/US20050197695?utm_source=gb-gplus-sharePatent US20050197695 - Minimally-invasive cardiac-valve prosthesisAdvanced Patent SearchPublication numberUS20050197695 A1Publication typeApplicationApplication numberUS 11/066,346Publication dateSep 8, 2005Filing dateFeb 25, 2005Priority dateMar 3, 2004Also published asDE602005012331D1, EP1570809A1, EP1570809B1, US8109996, US8535373, US20080255662, US20130325112Publication number066346, 11066346, US 2005/0197695 A1, US 2005/197695 A1, US 20050197695 A1, US 20050197695A1, US 2005197695 A1, US 2005197695A1, US-A1-20050197695, US-A1-2005197695, US2005/0197695A1, US2005/197695A1, US20050197695 A1, US20050197695A1, US2005197695 A1, US2005197695A1InventorsCarla Stacchino, Giovanni Bergamasco, Gaetano BurriesciOriginal AssigneeSorin Biomedica Cardio S.R.L.Export CitationBiBTeX, EndNote, RefManPatent Citations (99), Referenced by (248), Classifications (8), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetMinimally-invasive cardiac-valve prosthesis
1. A cardiac-valve prosthesis adapted for percutaneous implantation, the prosthesis comprising: an armature adapted for deployment in a radially expanded implantation position, the armature including a support portion and an anchor portion, which are substantially axially coextensive with respect to one another; and a set of leaflets coupled to the support portion, which can be deployed with the armature in the implantation position, wherein the leaflets define, in the implantation position, a flow duct that is selectably obstructable; wherein the anchor portion can be deployed to enable anchorage of the cardiac-valve prosthesis at an implantation site. 2. The prosthesis according to claim 1 wherein the anchor portion and the support portion of the armature are structurally distinct from one another. 3. The prosthesis according to claim 1 wherein the anchor portion and the support portion of the armature form different parts of a single structure. 4. The prosthesis according to claim 2 wherein the anchor portion of the armature has a set of ribs which, in the implantation position, are adapted to conform to a shape of the implantation site. 5. The prosthesis according to claim 4 wherein the ribs have at least one arched portion having an overall arched pattern. 6. The prosthesis according to claim 5 wherein the ribs of the anchor portion of the armature have a plurality of branches adapted to extend in an endocardial position. 7. The prosthesis according to claim 6 wherein the ribs of the anchor portion of the armature have a convex portion that is adapted to position astride a valve annulus site. 8. The prosthesis according to claim 6 wherein the ribs of the anchor portion of the armature include, respectively, a first branch and a second branch adapted to extend, respectively, in a distal position and a proximal position with respect to a valve annulus site. 9. The prosthesis according to claim 6 wherein the ribs of the anchor portion of the armature are grouped together into three sets, the sets being spaced generally equidistant about a circumference of the armature. 10. The prosthesis according to claim 1 wherein the support portion of the armature includes support ribs that are able to support the prosthetic valve leaflets in a commissural position. 11. The prosthesis according to claim 10 wherein the support ribs are grouped together into three sets. 12. The prosthesis according to claim 1 wherein a proximal portion of the set of leaflets includes, an apron-like portion that is able to extend in an endocardial site. 13. The prosthesis according to claim 12 wherein the anchor portion of the armature includes branches that are shaped to support the apron-like portion. 14. The prosthesis according to claim 1 wherein the armature is obtained from a tubular element comprising ribs having a general helical conformation. 15. The prosthesis according to claim 1 wherein the ribs are made of a superelastic material or a shape-memory material. 16. An cardiac-valve prosthesis adapted for percutaneous delivery and implantation at an anatomical valve site having a Valsalva sinus, the prosthesis comprising: an armature adapted for delivery in a radially-compressed configuration and deployment in a radially-expanded configuration at the valve site, the armature including a support portion and an anchor portion; and a set of leaflets coupled to the support portion, which can be deployed with the armature in the radially-expanded configuration, wherein the leaflets define a flow duct that is selectably obstructable; wherein the anchor portion includes ribs that in the radially-expanded configuration generally conform to the Valsalva sinus to enable anchorage of the cardiac-valve prosthesis at the valve site. 17. The prosthesis according to claim 16 wherein the anchor portion and the support portion of the armature are structurally distinct from one another. 18. The prosthesis according to claim 16 wherein the anchor portion and the support portion of the armature form different parts of a single structure. 19. The prosthesis according to claim 16 wherein the ribs are made from Nitinol. 20. The prosthesis according to claim 19 wherein the ribs are shaped to generally conform to the Valsalva sinus. 21. The prosthesis according to claim 20 wherein the ribs are shaped to apply a non-traumatic amount of stress to the Valsalva sinus. 22. The prosthesis according to claim 17 wherein the ribs include a proximal portion generally shaped to conform to an intraventricular portion of the valve annulus. 23. The prosthesis according to claim 17 wherein the anchor portion includes three sets of ribs, the ribs spaced circumferentially about the armature such that each set of ribs is adapted to generally conform to each or three corresponding Valsalva sinuses. 24. The prosthesis according to claim 16 wherein the ribs of the anchor portion of the armature have a convex portion that, in a pre-stressed condition, is shaped to position astride a valve annulus site.
CROSS REFERENCE TO RELATED APPLICATION [0001] This application claims priority from Italian patent application number TO2004/A000135, filed on Mar. 3, 2004, which is hereby incorporated by reference. TECHNICAL FIELD [0002] The present invention relates to cardiac-valve prostheses. More specifically, the present invention is directed to a prosthesis that is amenable to minimally-invasive implantation. BACKGROUND [0003] Recently, there has been increasing consideration given to the possibility of using, as an alternative to traditional cardiac-valve prostheses, valves designed to be implanted using minimally-invasive surgical techniques or endovascular delivery (the so-called “percutaneous valves”). Implantation of a percutaneous valve (or implantation using thoracic-microsurgery techniques) is a far less invasive act than the surgical operation required for implanting traditional cardiac-valve prostheses. Further details of exemplary percutaneous implantation techniques are provided in U.S. Publication 2002/0042651, U.S. Pat. No. 3,671,979, and U.S. Pat. No. 5,954,766, which are hereby incorporated by reference. [0004] These prosthetic valves typically include an anchoring structure, which is able to support and fix the valve prosthesis in the implantation position, and prosthetic valve elements, generally in the form of leaflets or flaps, which are stably connected to the anchoring structure and are able to regulate blood flow. [0005] Furthermore, the methods of implantation of valves via a percutaneous route or by means of thoracic microsurgery are very frequently irrespective of the effective removal of the natural valve leaflets. Instead, the cardiac valve may be introduced in a position corresponding to the natural annulus and deployed in situ by simply divaricating definitively the natural valve leaflets. [0006] There is a need for a percutaneous valve that does not run the risk of being displaced (dislodged) with respect to the implantation position, as a result of the hydraulic thrust exerted by the blood flow. There is a further need for a percutaneous valve that secures tightly to the flow duct generally defined by the natural valve annulus, such that it resists blood flow around the outside of the percutaneous valve structure. SUMMARY [0007] In an exemplary embodiment, the invention described herein is based on the concept of separating, in the framework of the supporting armature of the valve, the function of anchorage of the valve in the implantation site (including the possible function of sealing the valve with respect to the blood-flow duct natural to the region in which the valve is implanted) and the valve function proper. In a preferred way, this purpose is achieved by providing, within the armature of the valve, two structures (which are functionally distinct, but which in effect may be structurally integrated with one another), which are delegated separately to the accomplishment of these two functions. These two structures or portions comprise an external portion which can be spread out to enable anchorage of the cardiac-valve prosthesis at the implantation site, and an internal portion, which is substantially axially coextensive with the external portion, for supporting the prosthetic valve leaflets. The valve thus obtained is adapted in a particularly advantageous way to be implanted in a position corresponding to the so-called Valsalva's sinuses. [0008] While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the invention. As will be realized, the invention is capable of modifications in various obvious aspects, all without departing from the spirit and scope of the present invention. Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive.
BRIEF DESCRIPTION OF THE DRAWINGS [0009] FIG. 1 is a general perspective view of a prosthetic valve according to the invention. [0010] FIG. 2 illustrates the corresponding armature of the valve without the leaflets. [0011] FIGS. 3 and 4 illustrate a second exemplary embodiment of a prosthetic valve according to the invention.
[0012] While the invention is amenable to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and are described in detail below. The intention, however, is not to limit the invention to the particular embodiments described. On the contrary, the invention is intended to cover all modifications, equivalents, and alternatives falling within the scope of the invention as defined by the appended claims. DETAILED DESCRIPTION [0013] In the figures, the reference number 1 designates as a whole a cardiac valve, which can be implanted via percutaneous route or resorting to thoracic-microsurgery techniques. These percutaneous implantation techniques are generally known in the art, and include those techniques described in the documents referenced above. [0014] The valve 1 represented in FIGS. 1 and 2 is basically made up of two elements, namely an armature 2, having the characteristics that emerge more clearly from the representation of FIG. 2, and a set of leaflets 3, coupled to the armature 2. The characteristics of the leaflets 3 may be appreciated more fully from the view of FIG. 1. [0015] As shown in FIG. 2, the armature 2 of the valve has a general cage-like structure comprising a set of ribs that extend with a general symmetry of a cylindrical type about a principal axis X4. In percutaneous valves, the axis X4 usually corresponds to the principal axis of the distal part of the catheter used for implantation of the valve 1. For the present purposes, the axis X4 can be viewed basically as an entity of a purely geometrical nature, even though it can in effect be identified either with elements of the implantation catheter or with elements of the armature 2 of the valve 1. [0016] The armature 2 includes a distinguishable first and a second series of ribs designated, respectively, by the reference numbers 5 and 6. These ribs are usually made of metal material that is able to present characteristics of radial expandability, both as a result of a positive action of a dilatation or divarication force exerted by, for example, a balloon catheter and as a result of characteristics proper to the material constituting the ribs 5 (and possibly 6). In particular, the ribs may be made of a superelastic material and/or a material with shape-memory characteristics. A material that is well known in biomedical applications and that presents these characteristics is the material known as Nitinol. [0017] Structures that may substantially be likened to cages, which can be introduced into a vessel of the human body and in particular into a venous site and can then be dilated in loco via dilatation of a distal part of the introducing catheter or, in the case of materials with shape-memory characteristics or the like, as a result of the retraction of a sheath that maintains the structure in a compressed position, are well known in the art. For example, these structures are well known in stent technology and, in particular, the technology of stents for angioplasty. [0018] Due to the possibility of providing cage-like structures with ribs extending with a profile more or less shaped in diametral planes with reference to a principal axis, such as for example the axis X4, further reference may be made to technologies adopted for the fabrication of devices for the mapping or passivation of endocardial sites, such as, typically, endocavitary sites, used for localization and/or treatment of the so-called ectopic sites characteristic of the pathological conditions of a fibrillative type. [0019] The distinction made between the ribs 5 and 6 is based on the fact that, within the armature 2, these different sets of ribs are designed to perform different functions, regardless of whether the ribs constitute physically distinct parts or are different portions of a unitary structure within the armature 2. In particular, the ribs 5 form an external part or anchor portion of the armature 2 designed (see FIG. 1) to enable the location and anchorage of the valve 1 at the implantation site. The ribs 6 are designed to constitute a more internal part or support portion of the armature 2, specifically the part that is to support the valve leaflets 30 of the prosthesis. Essentially, the ribs 5 and 6 are designed to define, within the armature 2, an external portion (ribs 5), which can be spread out or radially expanded to enable anchorage of the prosthesis 1 in the implantation site and an internal portion (ribs 6), which supports the prosthetic valve leaflets 30 provided in the set of leaflets 3. [0020] An important characteristic of the solution described herein is provided by the fact that the two portions of the armature 2 are “substantially axially coextensive” with respect to one another. This definition is understood to indicate synthetically the fact that the two portions occupy, in the direction of the axis X4, axial stretches that are substantially coincident with one another. This is in direct contrast with solutions such as the one described, for example, in the U.S. Pat. No. 6,482,228, which illustrates a valve comprising two homologous portions that are totally staggered with respect to one another in an axial direction so that they can be located, one in a proximal position and the other in a distal position with respect to the coronary ostia. [0021] The ribs 5, which in what follows are designated also as “external” ribs, are preferably arranged in sets of ribs, said sets being typically arranged in threes or multiples of three so as to be more readily adaptable, in a complementary way, to the anatomy of the Valsalva's sinuses, which is the site of choice for implantation of the valve 1. [0022] In an exemplary embodiment, within the ribs 5 there is distinguishable a top part or top branch 50 and a bottom part or bottom branch 51. In the implantation position, the top parts or branches 50 are able, when they are in the deployed or expanded position, to extend within the so-called Valsalva's sinuses. The Valsalva's sinuses are the dilatations, from the overall lobed profile, which are present at the root of the aorta, hence in a physiologically distal position with respect to the aortic valve annulus. The bottom portions or branches 51 (see FIG. 1) are instead designed to extend in a proximal position with respect to the valve annulus so as to extend for a certain stretch within the ventricular chamber. [0023] As a whole, the top parts 50 of the ribs 5, when brought into the extended position, jointly define a tripodal structure, which, by expanding within the Valsalva's sinuses, enables attainment of a condition of firm anchorage of the valve 1. This avoids the possibility of the valve 1, once implanted, being dislodged or even just displaced with respect to the implantation position, as a result of the hydraulic stresses applied thereto during operation by the blood flow. [0024] The anchorage of the valve 1 in the implantation site is further reinforced by the fact that the area of radiusing between the top branches 50 and the bottom branches 51 of the ribs 5 has, precisely on account of the general divaricated or flared pattern of the bottom branches 51, an area of convexity that is thus positioned astride of the valve annulus, reinforcing the condition of shape fit between the armature of the valve and the implantation site. In the schematic representation of the figures, the natural valve leaflets of the valve that is to be replaced with the prosthetic valve 1 are not specifically illustrated. [0025] The valve 1 described herein can be located in situ regardless of whether the natural valve leaflets have previously been removed or (and in a way that is from certain points of view preferred), without proceeding to the removal of said natural valve leaflets, by simply introducing the valve within the valve orifice and thus bringing about, as a result of the divarication of the valve 1 structure, the corresponding definitive divarication of the natural valve leaflets that are brought into, and maintained in, a position of substantial adherence to the surrounding portion of the valve annulus. [0026] The particular conformation of the ribs 5, and in particular of the parts 50 and 51 just described, corresponds to the solution envisaged for the implantation of the valve 1 in the aortic site. Similar structures can be adopted for implantations, for example, in the mitral site. [0027] The top and bottom branches 50 and 51 may in actual fact present conformations that are altogether different from the ones illustrated. For example, the top branches 50 may possibly present a conformation that is approximately symmetrical to the conformation represented herein with reference to the bottom branches 51, thus conferring on the external part of the armature of the valve 2 an overall hourglass conformation. Moreover, the presence of both of the branches 50 and 51 is altogether optional. [0028] Again, in the exemplary embodiment illustrated herein, the terminal top ends of the branches 50 and the bottom ends of the branches 51 are connected to collar parts 52, which are designed to be fitted around, and usually to slide along the principal axis X4 during divarication of the armature 2. This solution proves advantageous as regards to the simplicity and the structural congruence of the armature 2. Recourse thereto should, however, be reconciled with the need to prevent the collar parts 52 from possibly ending up playing an excessive role of obstruction in regard to the blood flow that is to pass (from below upwards, with reference to the configuration of implantation as represented in FIG. 1) through the central orifice of the valve 1 defined between the valve leaflets 30 in a divaricated position. For example, it is conceivable to use just one of the collars 52, for example the one illustrated in the bottom portion in FIG. 2. [0029] The structure and the configuration of the ribs 6 is, as a whole, akin to that of the ribs 5. In the case of the ribs 6, which form the internal part of the armature 2 of the valve 1, there is, however, usually the presence of just three elements that support, in a position corresponding to homologous lines of commissure (which take material form as sutures 31 passing through openings 61 provided on the elements 6), the valve leaflets 30. Essentially, the complex of ribs 6 and valve leaflets 30 is designed to form the normal structure of a biological valve prosthesis. This is a valve prosthesis which (in the form that is to be implanted with a surgical operation of a traditional type, hence of an invasive nature) has met with a wide popularity in the art. [0030] The structural details of biological valve prostheses, consisting of a tubular structure made of biological material (for example, the pericardium or meningeal tissue of animal origin) subjected to treatments of passivation (with gluteraldehyde or similar compounds) or alternatively a biocompatible synthetic material, after prior possible shaping of the cusp-like areas that are to constitute the prosthetic valve leaflets 30, are well known in the art. For further details of the structure of such a valve, reference can be made to EP-B-0 155 245, which is hereby incorporated by reference. For further details of the technology of fabrication and/or treatment of the material of the prosthetic valve leaflets, useful reference can be made to EP-B-0 133 420, which is hereby incorporated by reference. [0031] In addition to the more strictly “valve” part comprising the prosthetic valve leaflets 30 supported in a commissural position by the ribs 6 of the armature 2, the leaflet part of the prosthesis illustrated also has an apron-like part 32, which extends according to a general chimney-like or flared configuration and is supported by the bottom parts 51 of the external ribs 5 of the armature 2. For this purpose, the bottom parts 51 have an overall V-shaped structure, hence comprising two branches that are to enclose within them the chimney-like portion 32 of the set of leaflets 3 of the valve armature 2, so causing this to be divaricated at the moment of spreading out of the valve and maintained in said divaricated position in the intraventricular site in a proximal position with respect to the valve annulus. [0032] Albeit conserving an extreme structural simplicity, from which there derives a corresponding reliability during implantation, the valve structure described manages to meet in an excellent way various needs that in themselves contrast with one another. This is obtained basically by separating the two parts of the armature 2, which are functionally distinct, even though they may be integrated in a single structure, and hence delegating to them two different functions. [0033] In particular, the external ribs 5 (and more specifically when these are present in the two branches 50 and 51, which can be positioned astride of the valve annulus) provide the firm anchorage of the valve in situ, so preventing it from possibly being removed or even just displaced from the implantation site chosen by the person carrying out the implantation operation. This is obtained with a structure that is able to adapt to the natural anatomical conformation without exerting thereon stresses of a traumatic nature. [0034] As shown in the Figures, the ribs 5 can present a rather thin or light structure. This allows them to adhere to the walls of the root of the aorta, to the surrounding portion of the valve annulus, and to the walls of the endocardial chamber, without exerting particularly marked stresses on those walls, which—in extreme cases—could even be at the basis of phenomena of lesions and, even more, of onset of reactions of the organism in regard to said lesions. The action of anchorage is in fact achieved, more than for any other reason, on account of the presence of numerous ribs 5 and their conformation, which is complementary with respect to that of the implantation site (in particular, when this is represented by the Valsalva's sinuses). [0035] The internal part of the armature 2, represented by the ribs 6, enables, spreading out and support of the prosthetic valve leaflets 30 in the implantation position. This is achieved by recourse to a structure and a conformation which, precisely because they reproduce very closely those of traditional prosthetic valves of a biological type, prove particularly suitable and efficient for performing substitution of a defective natural valve. In particular, it is well known that valve prostheses of a biological type, precisely because they are able to reproduce closely the fluid-dynamic characteristics and the characteristics of behaviour of the leaflets of natural cardiac valves, can be used to benefit patients affected by forms of rather marked cardiac insufficiency. This possibility is achieved in an optimal way in the solution described herein precisely because the valve function is rendered altogether independent of the function of anchorage in situ of the prosthesis. [0036] The presence of the branches 51 in the armature 2 of the prosthesis and, conversely, of the apron-like or chimney-like portion 32 in the set of leaflets 3 (in addition to contributing further to the shape fit and hence to the anchorage in the implantation site of the valve 1) likewise enables very efficient channelling of the blood flow coming from the heart, channelling it in a practically complete way, precisely on account of the divaricated or flared configuration of the chimney-like portion 32 within the flow duct defined within the valve leaflets 30. There is thus minimized (and in effect cancelled out) shortly following implantation, the possibility of there being created lines of blood flow that pass on the outside of the cardiac-valve prosthesis. [0037] The foregoing likewise envisages that the two parts or portions of armature 2 are substantially axially coextensive with respect to one another, occupying, if viewed in their development in the direction of the axis X4, axial stretches substantially coinciding with one another. This characteristic enables a precise positioning of the prosthetic valve leaflets in a “physiological” location (i.e., in a location basically corresponding to the location of the natural valve leaflets), likewise benefiting, for the purposes of the anchorage of the prosthesis in situ, from a shape fit with the Valsalva's sinuses. [0038] FIGS. 3 and 4 illustrate a second exemplary embodiment of a cardiac valve, according to the present invention. From a general structural standpoint, the valve of FIGS. 3 and 4 derives basically from the structure of the valve shown in FIGS. 1 and 2. The valve according to FIGS. 3 and 4 is obtained by recourse, as regards the armature, to a single element of tubular shape and reticular structure. In particular, FIG. 3 illustrates this tubular element in an “extroverted” or “extended” configuration, whereas in FIG. 4 the same element is illustrated in an “introverted” configuration, corresponding to the final conformation of implantation of the valve. [0039] In this particular embodiment, the two parts or portions of the armature 2 (the external portion 5 for anchorage of the valve 1 in the implantation site and the internal portion 6 with the function of supporting the valve leaflets) are integrated in a single structure consisting precisely of the tubular element referred to previously. This element, designated as a whole by reference numeral 2, has a substantially cylindrical structure that develops about a principal axis X4 and consists of ribs having a general helical conformation and presenting joints in pairs 53 and 63 at the two ends. The armature 2 is without any discontinuity between the external portion 5 and the internal portion 6 of the ribs. The ribs that form the armature 2 in this embodiment are basically made of a superelastic material and/or shape-memory material. [0040] The valve 1 passes from the extroverted configuration (FIG. 3) to the introverted or final configuration (FIG. 4) through a mechanism of deformation that may be obtained at the implantation site. This can occur, in the case of percutaneous valves, via remote manipulation devices associated to the catheter for introduction of the valve. Said devices are in themselves known in so far as they are used in association with catheters of various types, for example to obtain actions of selective spreading out of implantation devices, such as stents, stent-grafts or the like. [0041] The mechanism of deployment (i.e., introversion) in question involves passing from the extended conformation of FIG. 3 to the final conformation of FIG. 4, thereby causing the joints 63, to which the set of leaflets 3 are fixed (internally with respect to the original cylindrical tubular element), to converge within the tubular structure and then advance therein until the joints 63 arrive in the proximity of the joints 53, which, at the start of the movement of introversion described, were exactly at the opposite end of the original cylindrical tubular element. [0042] Basically, this movement causes the tubular element 2 to pass between an extroverted configuration (FIG. 3), in which said tubular element has a substantially cylindrical shape, with the external portion 5 and internal portion 6 of the armature axially juxtaposed with respect to one another, and a final introverted configuration (FIG. 4), in which the external portion 5 and internal portion 6 are substantially axially coextensive with respect to one another. [0043] This overall movement is usually accompanied by at least a slight divarication of the joints 53 and of the areas of the armature of the valve (external part 5) adjacent thereto. This divarication of the joints 53 and of the areas of the armature adjacent thereto is clearly perceptible in FIG. 4. In the same figure there is moreover perceptible the action of “pinching” of the apron-like part of the leaflet, which may be achieved with a positive action of deformation of the armature and/or by exploiting the shape-memory characteristics of the constituent material. Also in this case, a final configuration is reached, in which the external portion 5 and internal portion 6 of the armature 2 of the valve 1 are substantially axially coextensive with respect to one another, finding themselves occupying axial stretches that substantially coincide with respect to the axis X4. [0044] In the introverted configuration (see FIG. 4), it is possible to distinguish top branches 50 and bottom branches 51 of the ribs 5, in a conformation suitable for being implanted in the Valsalva's sinuses. The top branches 50 extend in a generally cage-like form, which is complementary with the lobed anatomy of the Valsalva's sinuses and co-operate with the bottom branches 51, which are to extend in a proximal position with respect to the valve annulus so as to be introduced within the ventricular chamber, ensuring a firm anchorage of the valve 1 at the implantation site. The set of leaflets 3 comprises the prosthetic valve leaflets 30 supported by the internal ribs 6 and an apron-like part 32 supported by and fixed to the bottom branches 51 of the external ribs 5. [0045] Various modifications and additions can be made to the exemplary embodiments discussed without departing from the scope of the present invention. Accordingly, the scope of the present invention is intended to embrace all such alternatives, modifications, and variations as fall within the scope of the claims, together with all equivalents thereof. Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3334629 *Nov 9, 1964Aug 8, 1967Bertram D CohnOcclusive device for inferior vena cavaUS3409013 *Oct 23, 1965Nov 5, 1968Berry HenryInstrument for inserting artificial heart valvesUS3540431 *Apr 4, 1968Nov 17, 1970Kazi Mobin UddinCollapsible filter for fluid flowing in closed passagewayUS3587115 *Dec 1, 1967Jun 28, 1971Shiley Donald PProsthetic sutureless heart valves and implant tools thereforUS3608097 *Jan 3, 1969Sep 28, 1971Bellhouse Brian JohnNon-return valves particularly as prostheticsUS3628535 *Nov 12, 1969Dec 21, 1971Nibot CorpSurgical instrument for implanting a prosthetic heart valve or the likeUS3642004 *Jan 5, 1970Feb 15, 1972Life Support Equipment CorpUrethral valveUS3657744 *May 8, 1970Apr 25, 1972Univ MinnesotaMethod for fixing prosthetic implants in a living bodyUS3671979 *Sep 23, 1969Jun 27, 1972Univ UtahCatheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valveUS3744060 *Jun 10, 1971Jul 10, 1973Bellhouse BProsthetic cardiac valveUS3755823 *Apr 23, 1971Sep 4, 1973Hancock Laboratories IncFlexible stent for heart valveUS3795246 *Jan 26, 1973Mar 5, 1974Bard Inc C RVenocclusion deviceUS3839741 *Nov 17, 1972Oct 8, 1974Haller JHeart valve and retaining means thereforUS3868956 *Jun 5, 1972Mar 4, 1975Ralph J AlfidiVessel implantable appliance and method of implanting itUS3874388 *Feb 12, 1973Apr 1, 1975Ochsner Med Found AltonShunt defect closure systemUS4035849 *Jun 25, 1976Jul 19, 1977William W. AngellHeart valve stent and process for preparing a stented heart valve prosthesisUS4056854 *Sep 28, 1976Nov 8, 1977The United States Of America As Represented By The Department Of Health, Education And WelfareAortic heart valve catheterUS4086665 *Dec 16, 1976May 2, 1978Thermo Electron CorporationArtificial blood conduitUS4106129 *Aug 26, 1977Aug 15, 1978American Hospital Supply CorporationSupported bioprosthetic heart valve with compliant orifice ringUS4222126 *Dec 14, 1978Sep 16, 1980The United States Of America As Represented By The Secretary Of The Department Of Health, Education & WelfareUnitized three leaflet heart valveUS4233690 *May 19, 1978Nov 18, 1980Carbomedics, Inc.Prosthetic device couplingsUS4265694 *Jan 22, 1980May 5, 1981The United States Of America As Represented By The Department Of Health, Education And WelfareMethod of making unitized three leaflet heart valveUS4291420 *Jun 13, 1980Sep 29, 1981Medac Gesellschaft Fur Klinische Spezialpraparate MbhArtificial heart valveUS4297749 *Feb 27, 1980Nov 3, 1981Albany International Corp.Heart valve prosthesisUS4339831 *Mar 27, 1981Jul 20, 1982Medtronic, Inc.Dynamic annulus heart valve and reconstruction ringUS4343048 *Aug 4, 1980Aug 10, 1982Ross Donald NStent for a cardiac valveUS4345340 *May 7, 1981Aug 24, 1982Vascor, Inc.Stent for mitral/tricuspid heart valveUS4425908 *Oct 22, 1981Jan 17, 1984Beth Israel HospitalBlood clot filterUS4451936 *Dec 21, 1981Jun 5, 1984American Hospital Supply CorporationSupra-annular aortic valveUS4477930 *Sep 28, 1982Oct 23, 1984Mitral Medical International, Inc.Natural tissue heat valve and method of making sameUS4777951 *Sep 19, 1986Oct 18, 1988Mansfield Scientific, Inc.Procedure and catheter instrument for treating patients for aortic stenosisUS4994077 *Apr 21, 1989Feb 19, 1991Dobben Richard LArtificial heart valve for implantation in a blood vesselUS5332402 *May 12, 1992Jul 26, 1994Teitelbaum George PPercutaneously-inserted cardiac valveUS5370685 *Jul 16, 1991Dec 6, 1994Stanford Surgical Technologies, Inc.Endovascular aortic valve replacementUS5397351 *May 13, 1991Mar 14, 1995Pavcnik; DusanProsthetic valve for percutaneous insertionUS5411552 *Jun 14, 1994May 2, 1995Andersen; Henning R.Valve prothesis for implantation in the body and a catheter for implanting such valve prothesisUS5545214 *Mar 4, 1994Aug 13, 1996Heartport, Inc.Endovascular aortic valve replacementUS5554185 *Jul 18, 1994Sep 10, 1996Block; Peter C.Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of sameUS5824064 *Nov 19, 1996Oct 20, 1998Taheri; Syde A.Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus thereforUS5840081 *Feb 19, 1997Nov 24, 1998Andersen; Henning RudSystem and method for implanting cardiac valvesUS5855597 *May 7, 1997Jan 5, 1999Iowa-India Investments Co. LimitedStent valve and stent graft for percutaneous surgeryUS5855601 *Jun 21, 1996Jan 5, 1999The Trustees Of Columbia University In The City Of New YorkArtificial heart valve and method and device for implanting the sameUS5925063 *Sep 26, 1997Jul 20, 1999Khosravi; FarhadCoiled sheet valve, filter or occlusive device and methods of useUS5954766 *Sep 16, 1997Sep 21, 1999Zadno-Azizi; Gholam-RezaBody fluid flow control deviceUS5957949 *May 1, 1997Sep 28, 1999World Medical Manufacturing Corp.Percutaneous placement valve stentUS5980570 *Mar 27, 1998Nov 9, 1999Sulzer Carbomedics Inc.System and method for implanting an expandable medical device into a bodyUS6168614 *Feb 20, 1998Jan 2, 2001Heartport, Inc.Valve prosthesis for implantation in the bodyUS6402780 *May 6, 1999Jun 11, 2002Cardiovascular Technologies, L.L.C.Means and method of replacing a heart valve in a minimally invasive mannerUS6425916 *Feb 10, 1999Jul 30, 2002Michi E. GarrisonMethods and devices for implanting cardiac valvesUS6454799 *Apr 6, 2000Sep 24, 2002Edwards Lifesciences CorporationMinimally-invasive heart valves and methods of useUS6458153 *Dec 31, 1999Oct 1, 2002Abps Venture One, Ltd.Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereofUS6482228 *Nov 14, 2000Nov 19, 2002Troy R. NorredPercutaneous aortic valve replacementUS6582462 *Feb 28, 2000Jun 24, 2003Heartport, Inc.Valve prosthesis for implantation in the body and a catheter for implanting such valve prosthesisUS6652578 *May 11, 2001Nov 25, 2003Abps Venture One, Ltd.Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereofUS6685739 *Jul 9, 2002Feb 3, 2004Scimed Life Systems, Inc.Implantable prosthetic valveUS6730118 *Oct 11, 2002May 4, 2004Percutaneous Valve Technologies, Inc.Implantable prosthetic valveUS6733525 *Mar 23, 2001May 11, 2004Edwards Lifesciences CorporationRolled minimally-invasive heart valves and methods of useUS6805711 *Jun 17, 2002Oct 19, 20043F Therapeutics, Inc.Expandable medical implant and percutaneous deliveryUS6830584 *Nov 15, 2000Dec 14, 2004Jacques SeguinDevice for replacing a cardiac valve by percutaneous routeUS6830585 *Jan 14, 2003Dec 14, 20043F Therapeutics, Inc.Percutaneously deliverable heart valve and methods of implantationUS6875231 *Sep 11, 2002Apr 5, 20053F Therapeutics, Inc.Percutaneously deliverable heart valveUS20010007956 *Feb 28, 2001Jul 12, 2001Brice LetacValve prosthesis for implantation in body channelsUS20010010017 *Feb 28, 2001Jul 26, 2001Brice LetacAlve prosthesis for implantation in body channelsUS20010039450 *Feb 5, 2001Nov 8, 2001Dusan PavcnikImplantable vascular deviceUS20020042651 *Jun 29, 2001Apr 11, 2002Liddicoat John R.Method and apparatus for performing a procedure on a cardiac valveUS20020058995 *Oct 23, 2001May 16, 2002Stevens John H.Endovascular aortic valve replacementUS20020138138 *Mar 23, 2001Sep 26, 2002Jibin YangRolled minimally-invasive heart valves and methods of useUS20020151970 *Jun 3, 2002Oct 17, 2002Garrison Michi E.Methods and devices for implanting cardiac valvesUS20020198594 *Jun 28, 2002Dec 26, 2002Stefan SchreckMinimally-invasive heart valves and methods of useUS20030014104 *May 2, 2002Jan 16, 2003Alain CribierValue prosthesis for implantation in body channelsUS20030023300 *Sep 30, 2002Jan 30, 2003Bailey Steven R.Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereofUS20030023303 *Apr 11, 2002Jan 30, 2003Palmaz Julio C.Valvular prostheses having metal or pseudometallic construction and methods of manufactureUS20030036795 *Oct 10, 2002Feb 20, 2003Andersen Henning RudValve prosthesis for implantation in the body and a catheter for implanting such valve prosthesisUS20030055495 *Nov 1, 2002Mar 20, 2003Pease Matthew L.Rolled minimally-invasive heart valves and methods of manufactureUS20030109924 *Jul 23, 2002Jun 12, 2003Alain CribierImplanting a valve prosthesis in body channelsUS20030130729 *Jan 4, 2002Jul 10, 2003David PaniaguaPercutaneously implantable replacement heart valve device and method of making sameUS20030153974 *Oct 11, 2001Aug 14, 2003Benjamin SpenserImplantable prosthetic valveUS20030163194 *May 2, 2002Aug 28, 2003Quijano Rodolfo C.Supportless atrioventricular heart valve and minimally invasive delivery systems thereofUS20030191528 *Jun 17, 2002Oct 9, 2003Quijano Rodolfo C.Expandable medical implant and percutaneous deliveryUS20040034411 *Aug 16, 2002Feb 19, 2004Quijano Rodolfo C.Percutaneously delivered heart valve and delivery means thereofUS20040039436 *Aug 8, 2003Feb 26, 2004Benjamin SpenserImplantable prosthetic valveUS20040049266 *Sep 11, 2002Mar 11, 2004Anduiza James PeterPercutaneously deliverable heart valveUS20040078072 *Nov 26, 2003Apr 22, 20043F Therapeutics, Inc.Delivery system for a stentless valve bioprosthesisUS20040093060 *Apr 10, 2003May 13, 2004Jacques SeguinProsthetic valve for transluminal deliveryUS20040106976 *Nov 24, 2003Jun 3, 2004Bailey Steven R.Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereofUS20050075584 *Oct 6, 2003Apr 7, 2005Cali Douglas S.Minimally invasive valve replacement systemUS20050075712 *Oct 6, 2003Apr 7, 2005Brian BiancucciMinimally invasive valve replacement systemUS20050075713 *Oct 6, 2003Apr 7, 2005Brian BiancucciMinimally invasive valve replacement systemUS20050075717 *Oct 6, 2003Apr 7, 2005Nguyen Tuoc TanMinimally invasive valve replacement systemUS20050075718 *Oct 6, 2003Apr 7, 2005Nguyen Tuoc TanMinimally invasive valve replacement systemUS20050075719 *Oct 6, 2003Apr 7, 2005Bjarne BergheimMinimally invasive valve replacement systemUS20050075720 *Oct 6, 2003Apr 7, 2005Nguyen Tuoc TanMinimally invasive valve replacement systemUS20050075724 *Oct 6, 2003Apr 7, 2005Oleg SvanidzeMinimally invasive valve replacement systemUS20050075726 *Oct 6, 2003Apr 7, 2005Oleg SvanidzeMinimally invasive valve replacement systemUS20050075728 *Oct 6, 2003Apr 7, 2005Nguyen Tuoc TanMinimally invasive valve replacement systemUS20050075729 *Oct 6, 2003Apr 7, 2005Nguyen Tuoc TanMinimally invasive valve replacement systemUS20050075730 *Oct 6, 2003Apr 7, 2005Myers Keith E.Minimally invasive valve replacement systemUS20050075731 *Oct 6, 2003Apr 7, 2005Jason ArtofMinimally invasive valve replacement systemUS20050234546 *Feb 7, 2005Oct 20, 2005Alan NugentTranscatheter delivery of a replacement heart valve* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS7201772Dec 30, 2004Apr 10, 2007Ventor Technologies, Ltd.Fluid flow prosthetic deviceUS7429269Jul 6, 2004Sep 30, 2008Ventor Technologies Ltd.Aortic prosthetic devicesUS7442204Nov 22, 2006Oct 28, 2008Ventor Technologies, Ltd.Fluid flow prosthetic deviceUS7655015Feb 2, 2010Evalve, Inc.Fixation devices, systems and methods for engaging tissueUS7666204Feb 23, 2010Evalve, Inc.Multi-catheter steerable guiding system and methods of useUS7682319Mar 23, 2010Evalve, Inc.Steerable access sheath and methods of useUS7682369Feb 14, 2006Mar 23, 2010Evalve, Inc.Surgical device for connecting soft tissueUS7704222Aug 30, 2004Apr 27, 2010Jenavalve Technology, Inc.Methods and conduits for flowing blood from a heart chamber to a blood vesselUS7712606Feb 2, 2006May 11, 2010Sadra Medical, Inc.Two-part package for medical implantUS7736327May 9, 2008Jun 15, 2010Jenavalve Technology, Inc.Methods and conduits for flowing blood from a heart chamber to a blood vesselUS7736388Jan 16, 2007Jun 15, 2010Evalve, Inc.Fixation devices, systems and methods for engaging tissueUS7748389Oct 21, 2004Jul 6, 2010Sadra Medical, Inc.Leaflet engagement elements and methods for use thereofUS7749266Jul 6, 2010Aortx, Inc.Methods and devices for delivery of prosthetic heart valves and other prostheticsUS7753923Aug 25, 2004Jul 13, 2010Evalve, Inc.Leaflet suturingUS7780725Jun 16, 2004Aug 24, 2010Sadra Medical, Inc.Everting heart valveUS7785341Aug 31, 2010Aortx, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of sameUS7811296Oct 12, 2010Evalve, Inc.Fixation devices for variation in engagement of tissueUS7824442Nov 2, 2010Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a heart valveUS7824443Feb 2, 2006Nov 2, 2010Sadra Medical, Inc.Medical implant delivery and deployment toolUS7857845Feb 10, 2006Dec 28, 2010Sorin Biomedica Cardio S.R.L.Cardiac-valve prosthesisUS7896913Mar 1, 2011Jenavalve Technology, Inc.Anchoring system for implantable heart valve prosthesesUS7896915Mar 1, 2011Jenavalve Technology, Inc.Medical device for treating a heart valve insufficiencyUS7914575Mar 29, 2011Jenavalve Technology, Inc.Medical device for treating a heart valve insufficiencyUS7938827May 10, 2011Evalva, Inc.Cardiac valve leaflet attachment device and methods thereofUS7959666Jun 14, 2011Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a heart valveUS7959672Jun 14, 2011Sadra MedicalReplacement valve and anchorUS7972378Jul 5, 2011Medtronic, Inc.Stents for prosthetic heart valvesUS7981123Feb 3, 2010Jul 19, 2011Evalve, Inc.Surgical device for connecting soft tissueUS7981139Jul 19, 2011Evalve, IncSuture anchors and methods of useUS7988724 *Aug 2, 2011Sadra Medical, Inc.Systems and methods for delivering a medical implantUS7993392Aug 9, 2011Sorin Biomedica Cardio S.R.L.Instrument and method for in situ deployment of cardiac valve prosthesesUS7998151Aug 16, 2011Evalve, Inc.Leaflet suturingUS8002826Oct 14, 2009Aug 23, 2011Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the bodyUS8006535Aug 30, 2011Sorin Biomedica Cardio S.R.L.Expandable prosthetic valve crimping deviceUS8016877Jun 29, 2009Sep 13, 2011Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8029518Oct 30, 2007Oct 4, 2011Evalve, Inc.Methods and devices for capturing and fixing leaflets in valve repairUS8052592Oct 7, 2009Nov 8, 2011Evalve, Inc.Methods and devices for tissue grasping and assessmentUS8052749 *Nov 8, 2011Sadra Medical, Inc.Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elementsUS8052750Nov 8, 2011Medtronic Ventor Technologies LtdValve prosthesis fixation techniques using sandwichingUS8057396May 7, 2010Nov 15, 2011Phoenix Biomedical, Inc.Device for assessing a cardiac valveUS8057493Dec 18, 2009Nov 15, 2011Evalve, Inc.Fixation devices, systems and methods for engaging tissueUS8057539Dec 19, 2006Nov 15, 2011Sorin Biomedica Cardio S.R.L.System for in situ positioning of cardiac valve prostheses without occluding blood flowUS8062355Nov 3, 2006Nov 22, 2011Jenavalve Technology, Inc.Self-expandable medical instrument for treating defects in a patient's heartUS8070799Dec 6, 2011Sorin Biomedica Cardio S.R.L.Instrument and method for in situ deployment of cardiac valve prosthesesUS8070801Dec 6, 2011Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valveUS8092487Jan 10, 2012Medtronic, Inc.Intravascular filter with debris entrapment mechanismUS8092521Jan 10, 2012Jenavalve Technology, Inc.Device for the implantation and fixation of prosthetic valvesUS8109996Feb 7, 2012Sorin Biomedica Cardio, S.R.L.Minimally-invasive cardiac-valve prosthesisUS8114154Sep 7, 2007Feb 14, 2012Sorin Biomedica Cardio S.R.L.Fluid-filled delivery system for in situ deployment of cardiac valve prosthesesUS8123703Feb 3, 2010Feb 28, 2012Evalve, Inc.Steerable access sheath and methods of useUS8128692Feb 25, 2005Mar 6, 2012Aortx, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of sameUS8136659May 10, 2010Mar 20, 2012Sadra Medical, Inc.Two-part package for medical implantUS8137398Oct 13, 2008Mar 20, 2012Medtronic Ventor Technologies LtdProsthetic valve having tapered tip when compressed for deliveryUS8142492Jun 20, 2007Mar 27, 2012Aortx, Inc.Prosthetic valve implantation systemsUS8147541Feb 27, 2006Apr 3, 2012Aortx, Inc.Methods and devices for delivery of prosthetic heart valves and other prostheticsUS8157852Jan 22, 2009Apr 17, 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8157853Apr 17, 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8182528Dec 23, 2003May 22, 2012Sadra Medical, Inc.Locking heart valve anchorUS8187299Oct 29, 2007May 29, 2012Evalve, Inc.Methods and apparatus for cardiac valve repairUS8206437Mar 19, 2009Jun 26, 2012Philipp BonhoefferImplant implantation unit and procedure for implanting the unitUS8216174Apr 30, 2010Jul 10, 2012Jenavalve Technology, Inc.Methods and conduits for flowing blood from a heart chamber to a blood vesselUS8216230Apr 4, 2011Jul 10, 2012Evalve, Inc.Cardiac valve leaflet attachment device and methods thereofUS8216256Feb 26, 2009Jul 10, 2012Evalve, Inc.Detachment mechanism for implantable fixation devicesUS8216301Jul 10, 2012Philipp BonhoefferImplant implantation unitUS8226710Mar 25, 2011Jul 24, 2012Medtronic Corevalve, Inc.Heart valve prosthesis and methods of manufacture and useUS8231670Jul 31, 2012Sadra Medical, Inc.Repositionable heart valve and methodUS8246678Mar 9, 2007Aug 21, 2012Sadra Medicl, Inc.Methods and apparatus for endovascularly replacing a patient's heart valveUS8252052Aug 28, 2012Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a patient's heart valveUS8287584Nov 14, 2005Oct 16, 2012Sadra Medical, Inc.Medical implant deployment toolUS8303653Nov 6, 2012Philipp BonhoefferImplant implantation unit and procedure for implanting the unitUS8313525Nov 20, 2012Medtronic Ventor Technologies, Ltd.Valve suturing and implantation proceduresUS8317858Feb 25, 2009Nov 27, 2012Jenavalve Technology, Inc.Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patientUS8328868Dec 11, 2012Sadra Medical, Inc.Medical devices and delivery systems for delivering medical devicesUS8343174Jan 1, 2013Evalve, Inc.Locking mechanisms for fixation devices and methods of engaging tissueUS8343213Oct 21, 2004Jan 1, 2013Sadra Medical, Inc.Leaflet engagement elements and methods for use thereofUS8348995Jan 8, 2013Medtronic Ventor Technologies, Ltd.Axial-force fixation member for valveUS8348996Mar 23, 2007Jan 8, 2013Medtronic Ventor Technologies Ltd.Valve prosthesis implantation techniquesUS8353953Jan 15, 2013Sorin Biomedica Cardio, S.R.L.Device for the in situ delivery of heart valvesUS8376865Jun 19, 2007Feb 19, 2013Cardiacmd, Inc.Torque shaft and torque shaft driveUS8398704Mar 19, 2013Jenavalve Technology, Inc.Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patientUS8403981Mar 26, 2013CardiacMC, Inc.Methods and devices for delivery of prosthetic heart valves and other prostheticsUS8403982Mar 26, 2013Sorin Group Italia S.R.L.Device for the in situ delivery of heart valvesUS8409273Apr 2, 2013Abbott Vascular IncMulti-catheter steerable guiding system and methods of useUS8414643Apr 9, 2013Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation memberUS8425593Sep 26, 2008Apr 23, 2013St. Jude Medical, Inc.Collapsible prosthetic heart valvesUS8430925Apr 30, 2013Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of sameUS8430927Feb 2, 2009Apr 30, 2013Medtronic, Inc.Multiple orifice implantable heart valve and methods of implantationUS8465540Jun 18, 2013Jenavalve Technology, Inc.Stent for the positioning and anchoring of a valvular prosthesisUS8468667May 12, 2010Jun 25, 2013Jenavalve Technology, Inc.Device for compressing a stentUS8470024Dec 19, 2006Jun 25, 2013Sorin Group Italia S.R.L.Device for in situ positioning of cardiac valve prosthesisUS8470028Jan 19, 2010Jun 25, 2013Evalve, Inc.Methods, systems and devices for cardiac valve repairUS8475521Jun 27, 2008Jul 2, 2013Sorin Group Italia S.R.L.Streamlined delivery system for in situ deployment of cardiac valve prosthesesUS8486137Jun 27, 2008Jul 16, 2013Sorin Group Italia S.R.L.Streamlined, apical delivery system for in situ deployment of cardiac valve prosthesesUS8500761Dec 11, 2009Aug 6, 2013Abbott VascularFixation devices, systems and methods for engaging tissueUS8500799Jun 20, 2007Aug 6, 2013Cardiacmd, Inc.Prosthetic heart valves, support structures and systems and methods for implanting sameUS8506620Nov 13, 2009Aug 13, 2013Medtronic, Inc.Prosthetic cardiac and venous valvesUS8512397Apr 27, 2009Aug 20, 2013Sorin Group Italia S.R.L.Prosthetic vascular conduitUS8535373Jun 16, 2008Sep 17, 2013Sorin Group Italia S.R.L.Minimally-invasive cardiac-valve prosthesisUS8539662Jun 16, 2008Sep 24, 2013Sorin Group Italia S.R.L.Cardiac-valve prosthesisUS8540768Dec 30, 2011Sep 24, 2013Sorin Group Italia S.R.L.Cardiac valve prosthesisUS8551160Dec 9, 2011Oct 8, 2013Jenavalve Technology, Inc.Device for the implantation and fixation of prosthetic valvesUS8579962Dec 20, 2005Nov 12, 2013Sadra Medical, Inc.Methods and apparatus for performing valvuloplastyUS8579965Nov 1, 2011Nov 12, 2013Jenavalve Technology, Inc.Methods of implanting an implantation deviceUS8585594May 24, 2006Nov 19, 2013Phoenix Biomedical, Inc.Methods of assessing inner surfaces of body lumens or organsUS8585756Oct 24, 2011Nov 19, 2013Jenavalve Technology, Inc.Methods of treating valvesUS8597226Jun 12, 2012Dec 3, 2013Jenavalve Technology, Inc.Methods and conduits for flowing blood from a heart chamber to a blood vesselUS8603159Dec 11, 2009Dec 10, 2013Medtronic Corevalve, LlcProsthetic valve for transluminal deliveryUS8603160Dec 23, 2003Dec 10, 2013Sadra Medical, Inc.Method of using a retrievable heart valve anchor with a sheathUS8608770Jul 28, 2010Dec 17, 2013Cardiacmd, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of sameUS8617236Nov 2, 2011Dec 31, 2013Sadra Medical, Inc.Medical devices and delivery systems for delivering medical devicesUS8623076Sep 22, 2011Jan 7, 2014Sadra Medical, Inc.Low profile heart valve and delivery systemUS8623077Dec 5, 2011Jan 7, 2014Medtronic, Inc.Apparatus for replacing a cardiac valveUS8623078Jun 8, 2011Jan 7, 2014Sadra Medical, Inc.Replacement valve and anchorUS8628570Aug 18, 2011Jan 14, 2014Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the bodyUS8640521Jul 7, 2011Feb 4, 2014Sorin Group Italia S.R.L.Expandable prosthetic valve crimping deviceUS8652204Jul 30, 2010Feb 18, 2014Medtronic, Inc.Transcatheter valve with torsion spring fixation and related systems and methodsUS8668733Nov 12, 2008Mar 11, 2014Sadra Medical, Inc.Everting heart valveUS8673000May 20, 2011Mar 18, 2014Medtronic, Inc.Stents for prosthetic heart valvesUS8679174Jan 12, 2006Mar 25, 2014JenaValve Technology, GmbHCatheter for the transvascular implantation of prosthetic heart valvesUS8685077Mar 14, 2012Apr 1, 2014Medtronics, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8685084Dec 28, 2012Apr 1, 2014Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly methodUS8685085Feb 18, 2011Apr 1, 2014JenaValve Technologies GmbHMedical device for treating a heart valve insufficiencyUS8715207Mar 18, 2010May 6, 2014Sorin Group Italia S.R.L.Universal valve annulus sizing deviceUS8721708Sep 23, 2011May 13, 2014Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8721714Sep 17, 2008May 13, 2014Medtronic Corevalve LlcDelivery system for deployment of medical devicesUS8728155Sep 20, 2013May 20, 2014Cephea Valve Technologies, Inc.Disk-based valve apparatus and method for the treatment of valve dysfunctionUS8728156Jan 30, 2012May 20, 2014Cardiac MD, Inc.Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of sameUS8734505Sep 24, 2009May 27, 2014Evalve, Inc.Methods and apparatus for cardiac valve repairUS8740918Jun 9, 2011Jun 3, 2014Evalve, Inc.Surgical device for connecting soft tissueUS8740920May 22, 2013Jun 3, 2014Evalve, Inc.Fixation devices, systems and methods for engaging tissueUS8747459Dec 6, 2007Jun 10, 2014Medtronic Corevalve LlcSystem and method for transapical delivery of an annulus anchored self-expanding valveUS8747460Dec 23, 2011Jun 10, 2014Medtronic Ventor Technologies Ltd.Methods for implanting a valve prothesisUS8771302Apr 6, 2007Jul 8, 2014Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valveUS8771345Oct 31, 2011Jul 8, 2014Medtronic Ventor Technologies Ltd.Valve prosthesis fixation techniques using sandwichingUS8771346Jul 25, 2011Jul 8, 2014Medtronic Ventor Technologies Ltd.Valve prosthetic fixation techniques using sandwichingUS8777980Dec 23, 2011Jul 15, 2014Medtronic, Inc.Intravascular filter with debris entrapment mechanismUS8784478Oct 16, 2007Jul 22, 2014Medtronic Corevalve, Inc.Transapical delivery system with ventruculo-arterial overlfow bypassUS8784481Sep 26, 2008Jul 22, 2014St. Jude Medical, Inc.Collapsible/expandable prosthetic heart valves with native calcified leaflet retention featuresUS8790395May 17, 2013Jul 29, 2014Jenavalve Technology GmbhStent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patientUS8801779May 10, 2011Aug 12, 2014Medtronic Corevalve, LlcProsthetic valve for transluminal deliveryUS8808367Sep 7, 2007Aug 19, 2014Sorin Group Italia S.R.L.Prosthetic valve delivery system including retrograde/antegrade approachUS8808369Oct 5, 2010Aug 19, 2014Mayo Foundation For Medical Education And ResearchMinimally invasive aortic valve replacementUS8828078Sep 20, 2005Sep 9, 2014Sadra Medical, Inc.Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elementsUS8834561Nov 22, 2013Sep 16, 2014Jenavalve Technology GmbhDevice for the implantation and fixation of prosthetic valvesUS8834563 *Dec 16, 2009Sep 16, 2014Sorin Group Italia S.R.L.Expandable prosthetic valve having anchoring appendagesUS8834564Mar 11, 2010Sep 16, 2014Medtronic, Inc.Sinus-engaging valve fixation memberUS8840661May 13, 2009Sep 23, 2014Sorin Group Italia S.R.L.Atraumatic prosthetic heart valve prosthesisUS8840662Oct 27, 2011Sep 23, 2014Sadra Medical, Inc.Repositionable heart valve and methodUS8840663Dec 23, 2003Sep 23, 2014Sadra Medical, Inc.Repositionable heart valve methodUS8845721Mar 21, 2013Sep 30, 2014St. Jude Medical, Inc.Collapsible prosthetic heart valvesUS8852272Mar 6, 2012Oct 7, 2014Mitraltech Ltd.Techniques for percutaneous mitral valve replacement and sealingUS8858620Jun 10, 2011Oct 14, 2014Sadra Medical Inc.Methods and apparatus for endovascularly replacing a heart valveUS8870948Jan 31, 2014Oct 28, 2014Cephea Valve Technologies, Inc.System and method for cardiac valve repair and replacementUS8870950Dec 7, 2010Oct 28, 2014Mitral Tech Ltd.Rotation-based anchoring of an implantUS8876894Mar 23, 2007Nov 4, 2014Medtronic Ventor Technologies Ltd.Leaflet-sensitive valve fixation memberUS8876895Mar 23, 2007Nov 4, 2014Medtronic Ventor Technologies Ltd.Valve fixation member having engagement armsUS8876896Dec 7, 2011Nov 4, 2014Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8894703Jun 22, 2011Nov 25, 2014Sadra Medical, Inc.Systems and methods for delivering a medical implantUS8920492Aug 21, 2013Dec 30, 2014Sorin Group Italia S.R.L.Cardiac valve prosthesisUS8940014Nov 14, 2012Jan 27, 2015Boston Scientific Scimed, Inc.Bond between components of a medical deviceUS8951243Nov 29, 2012Feb 10, 2015Boston Scientific Scimed, Inc.Medical device handleUS8951280Jun 9, 2010Feb 10, 2015Medtronic, Inc.Cardiac valve procedure methods and devicesUS8951299Oct 13, 2009Feb 10, 2015Sadra Medical, Inc.Medical devices and delivery systems for delivering medical devicesUS8956402Sep 14, 2012Feb 17, 2015Medtronic, Inc.Apparatus for replacing a cardiac valveUS8986361Oct 17, 2008Mar 24, 2015Medtronic Corevalve, Inc.Delivery system for deployment of medical devicesUS8992604Feb 24, 2011Mar 31, 2015Mitraltech Ltd.Techniques for percutaneous mitral valve replacement and sealingUS8992608Jun 26, 2009Mar 31, 2015Sadra Medical, Inc.Everting heart valveUS8998976Jul 12, 2012Apr 7, 2015Boston Scientific Scimed, Inc.Coupling system for medical devicesUS8998981Sep 15, 2009Apr 7, 2015Medtronic, Inc.Prosthetic heart valve having identifiers for aiding in radiographic positioningUS9005273Apr 4, 2007Apr 14, 2015Sadra Medical, Inc.Assessing the location and performance of replacement heart valvesUS9011521Dec 13, 2011Apr 21, 2015Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a patient's heart valveUS9017399Jul 21, 2011Apr 28, 2015Mitraltech Ltd.Techniques for percutaneous mitral valve replacement and sealingUS9044246Aug 24, 2011Jun 2, 2015Abbott Vascular Inc.Methods and devices for capturing and fixing leaflets in valve repairUS9044318Feb 26, 2008Jun 2, 2015Jenavalve Technology GmbhStent for the positioning and anchoring of a valvular prosthesisUS9044320Sep 6, 2013Jun 2, 2015Jenavalve Technology GmbhDevice for the implantation and fixation of prosthetic valvesUS9056008Nov 9, 2011Jun 16, 2015Sorin Group Italia S.R.L.Instrument and method for in situ development of cardiac valve prosthesesUS9060857Jun 19, 2012Jun 23, 2015Medtronic Corevalve LlcHeart valve prosthesis and methods of manufacture and useUS9060858May 28, 2013Jun 23, 2015Evalve, Inc.Methods, systems and devices for cardiac valve repairUS9066799Jan 20, 2011Jun 30, 2015Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS9131926Nov 5, 2012Sep 15, 2015Boston Scientific Scimed, Inc.Direct connect flush systemUS9132009Jul 21, 2010Sep 15, 2015Mitraltech Ltd.Guide wires with commissural anchors to advance a prosthetic valveUS9138312Jun 6, 2014Sep 22, 2015Medtronic Ventor Technologies Ltd.Valve prosthesesUS9138314Feb 10, 2014Sep 22, 2015Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly methodUS9138315Jun 14, 2007Sep 22, 2015Jenavalve Technology GmbhMedical device for treating a heart valve insufficiency or stenosisUS9149207Oct 16, 2013Oct 6, 2015Sorin Group Usa, Inc.Annuloplasty sizers for minimally invasive proceduresUS9149357Dec 23, 2013Oct 6, 2015Medtronic CV Luxembourg S.a.r.l.Heart valve assembliesUS9149358Jan 23, 2009Oct 6, 2015Medtronic, Inc.Delivery systems for prosthetic heart valvesUS9161836Feb 10, 2012Oct 20, 2015Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prosthesesUS9168105May 13, 2009Oct 27, 2015Sorin Group Italia S.R.L.Device for surgical interventionsUS9168130Oct 8, 2008Oct 27, 2015Jenavalve Technology GmbhStent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patientUS9168134Dec 21, 2011Oct 27, 2015Cardiacmd, Inc.Method for delivering a prosthetic heart valve with an expansion memberUS9226826Feb 24, 2010Jan 5, 2016Medtronic, Inc.Transcatheter valve structure and methods for valve deliveryUS9237886Apr 14, 2008Jan 19, 2016Medtronic, Inc.Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereofUS9241794Jul 17, 2014Jan 26, 2016St. Jude Medical, Inc.Collapsible prosthetic heart valvesUS9248017 *May 20, 2011Feb 2, 2016Sorin Group Italia S.R.L.Support device for valve prostheses and corresponding kitUS9254192Jun 22, 2015Feb 9, 2016Georg LutterTruncated cone heart valve stentUS9265631Sep 21, 2012Feb 23, 2016Jenavalve Technology, Inc.Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patientUS9277991Dec 31, 2013Mar 8, 2016Boston Scientific Scimed, Inc.Low profile heart valve and delivery systemUS9277993Dec 14, 2012Mar 8, 2016Boston Scientific Scimed, Inc.Medical device delivery systemsUS9289289Feb 10, 2012Mar 22, 2016Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prosthesesUS9289290May 19, 2014Mar 22, 2016St. Jude Medical, Inc.Collapsible/expandable prosthetic heart valves with native calcified leaflet retention featuresUS9295550Mar 28, 2014Mar 29, 2016Medtronic CV Luxembourg S.a.r.l.Methods for delivering a self-expanding valveUS9295551May 12, 2008Mar 29, 2016Jenavalve Technology GmbhMethods of implanting an endoprosthesisUS9301834Oct 16, 2009Apr 5, 2016Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation memberUS9308085Sep 23, 2014Apr 12, 2016Boston Scientific Scimed, Inc.Repositionable heart valve and methodUS9320599 *Sep 24, 2014Apr 26, 2016Boston Scientific Scimed, Inc.Methods and apparatus for endovascularly replacing a heart valveUS20030167071 *Mar 1, 2002Sep 4, 2003Evalve, Inc.Suture fasteners and methods of useUS20040003819 *Jul 3, 2003Jan 8, 2004Evalve, Inc.Methods and apparatus for cardiac valve repairUS20040087975 *May 19, 2003May 6, 2004Evalve, Inc.Fixation device delivery catheter, systems and methods of useUS20040092962 *May 19, 2003May 13, 2004Evalve, Inc., A Delaware CorporationMulti-catheter steerable guiding system and methods of useUS20040225300 *Mar 17, 2004Nov 11, 2004Evalve, Inc.Methods and devices for capturing and fixing leaflets in valve repairUS20040236354 *Jun 24, 2004Nov 25, 2004Evalve, Inc.Surgical device for connecting soft tissueUS20050137687 *Dec 23, 2003Jun 23, 2005Sadra MedicalHeart valve anchor and methodUS20050137689 *Dec 23, 2003Jun 23, 2005Sadra Medical, A Delware CorporationRetrievable heart valve anchor and methodUS20060089671 *Oct 27, 2004Apr 27, 2006Evalve, Inc.Fixation devices for variation in engagement of tissueUS20060135993 *Feb 14, 2006Jun 22, 2006Evalve, IncSurgical device for connecting soft tissueUS20060149360 *Dec 30, 2004Jul 6, 2006Ventor Technologies Ltd.Fluid flow prosthetic deviceUS20060259134 *Jul 6, 2004Nov 16, 2006Ehud SchwammenthalImplantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devicesUS20060287668 *Jun 16, 2005Dec 21, 2006Fawzi Natalie VApparatus and methods for intravascular embolic protectionUS20070185565 *Nov 22, 2006Aug 9, 2007Ventor Technologies Ltd.Fluid flow prosthetic deviceUS20080071366 *Mar 23, 2007Mar 20, 2008Yosi TuvalAxial-force fixation member for valveUS20080147160 *Dec 19, 2006Jun 19, 2008Sorin Biomedical Cardio S.R.L.System for in situ positioning of cardiac valve prostheses without occluding blood flowUS20080147181 *Dec 19, 2006Jun 19, 2008Sorin Biomedica Cardio S.R.L.Device for in situ axial and radial positioning of cardiac valve prosthesesUS20080262603 *Apr 23, 2007Oct 23, 2008Sorin Biomedica CardioProsthetic heart valve holderUS20090018570 *Jul 12, 2007Jan 15, 2009Sorin Biomedica Cardio S.R.L.Expandable prosthetic valve crimping deviceUS20090287296 *May 13, 2009Nov 19, 2009Sorin Biomedica Cardio S.R.L.Atraumatic prosthetic heart valve prosthesisUS20100100167 *Oct 17, 2008Apr 22, 2010Georg BortleinDelivery system for deployment of medical devicesUS20100161045 *Dec 16, 2009Jun 24, 2010Sorin Biomedica Cardio S.R.L.Expandable prosthetic valve having anchoring appendagesUS20100174363 *Jul 8, 2010Endovalve, Inc.One Piece Prosthetic Valve Support Structure and Related AssembliesUS20100185277 *Sep 26, 2008Jul 22, 2010St. Jude Medical, Inc.Collapsible prosthetic heart valvesUS20100249661 *Mar 18, 2010Sep 30, 2010Sorin Biomedica Cardio S.r.IUniversal Valve Annulus Sizing DeviceUS20100249923 *Sep 26, 2008Sep 30, 2010St Jude Medical Inc.Collapsible/expandable prosthetic heart valves with native calcified leaflet retention featuresUS20110040366 *Mar 2, 2009Feb 17, 2011Transcatheter Technologies GmbhStent which is reduceable again in its diameter from an expanded state in a controlled mannerUS20110288636 *Nov 24, 2011Sorin Biomedica Cardio S.R.L.Support device for valve prostheses and corresponding kitUS20150073540 *Sep 24, 2014Mar 12, 2015Sadra Medical, Inc.Methods and apparatus for endovascularly replacing a heart valveUSD732666Aug 9, 2011Jun 23, 2015Medtronic Corevalve, Inc.Heart valve prosthesisUSRE45130Feb 28, 2001Sep 9, 2014Jenavalve Technology GmbhDevice for fastening and anchoring cardiac valve prosthesesUSRE45790Aug 7, 2014Nov 3, 2015Jenavalve Technology GmbhDevice for the implantation and fixation of prosthetic valvesUSRE45962Aug 7, 2014Apr 5, 2016Jenavalve Technology GmbhDevice for the implantation and fixation of prosthetic valvesEP2047824A1Sep 26, 2008Apr 15, 2009Sorin Biomedica Cardio S.r.l.Expandable valve prothesis with sealing mechanismEP2119417A2May 13, 2009Nov 18, 2009Sorin Biomedica Cardio S.r.l.Atraumatic prosthetic heart valve prosthesisEP2229921A1Jul 12, 2007Sep 22, 2010Sorin Biomedica Cardio S.R.L.Expandable prosthetic valve crimping deviceEP2399527A1Sep 7, 2007Dec 28, 2011Sorin Biomedica Cardio S.r.l.Prosthetic valve delivery system including retrograde/antegrade approachWO2008035337A2Sep 19, 2007Mar 27, 2008Ventor Technologies, Ltd.Fixation member for valveWO2010045238A2Oct 13, 2009Apr 22, 2010Medtronic Ventor Technologies Ltd.Prosthetic valve having tapered tip when compressed for deliveryWO2011106137A1Feb 3, 2011Sep 1, 2011Medtronic Inc.Mitral prosthesisWO2011112706A2Mar 9, 2011Sep 15, 2011Medtronic Inc.Sinus-engaging fixation memberWO2012083070A1Dec 15, 2011Jun 21, 2012Medtronic Inc.Systems and methods for positioning a heart valve using visual markers* Cited by examinerClassifications U.S. Classification623/2.18, 623/2.38International ClassificationA61F2/24Cooperative ClassificationA61F2/2427, A61F2/2418, A61F2/2412European ClassificationA61F2/24D6, A61F2/24CLegal EventsDateCodeEventDescriptionJun 9, 2005ASAssignmentOwner name: SORIN BIOMEDICA CARDIO S.R.L., ITALYFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:STACCHINO, CARLA;BERGAMASCO, GIOVANNI;BURRIESCI, GAETANO;REEL/FRAME:016315/0025Effective date: 20050607Jul 26, 2013ASAssignmentOwner name: SORIN GROUP ITALIA S.R.L., ITALYFree format text: MERGER;ASSIGNOR:SORIN BIOMEDICA CARDIO S.R.L.;REEL/FRAME:030883/0215Effective date: 20121205Jul 22, 2015FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services