Source: http://www.google.com/patents/US4168326?ie=ISO-8859-1&dq=5,960,411
Timestamp: 2014-03-14 15:44:50
Document Index: 269941113

Matched Legal Cases: ['in fine', 'application No. 23', 'application No. 23', 'application No. 23', 'application No. 23', 'application No. 21', 'application No. 23', 'art 10']

Patent US4168326 - Prosthesis parts provided with a coating of a bio-active material, process ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsNovel prosthesis parts of improved properties are obtained by providing a material as used for prostheses with an enamel or enamel-like coating and incorporating in said enamel layer, while in a viscous state, a bioactive material. Such prosthesis parts have a satisfactory adhesive strength and coefficient...http://www.google.com/patents/US4168326?utm_source=gb-gplus-sharePatent US4168326 - Prosthesis parts provided with a coating of a bio-active material, process of making same, and method of using them for bone replacementAdvanced Patent SearchPublication numberUS4168326 APublication typeGrantApplication numberUS 05/733,313Publication dateSep 18, 1979Filing dateOct 18, 1976Priority dateOct 18, 1975Also published asDE2546824A1, DE2546824C2, US4365356Publication number05733313, 733313, US 4168326 A, US 4168326A, US-A-4168326, US4168326 A, US4168326AInventorsWerner Adam, Heinz Broemer, Friedhelm HedrichOriginal AssigneeErnst Leitz Wetzlar, GmbhExport CitationBiBTeX, EndNote, RefManPatent Citations (1), Non-Patent Citations (2), Referenced by (86), Classifications (31) External Links: USPTO, USPTO Assignment, EspacenetProsthesis parts provided with a coating of a bio-active material, process of making same, and method of using them for bone replacementUS 4168326 AAbstract Novel prosthesis parts of improved properties are obtained by providing a material as used for prostheses with an enamel or enamel-like coating and incorporating in said enamel layer, while in a viscous state, a bioactive material. Such prosthesis parts have a satisfactory adhesive strength and coefficient of expansion, are substantially free of pores, are highly corrosion resistant, and readily grow intimately and firmly together with the bone tissue without the use of bone cement.
We claim: 1. A process for providing metallic or non-metallic prosthesis working pieces with a coating of a bio-active material, not requiring high temperature treatment of the bio-active material, which process consists essentially of the steps of(a) providing the prosthesis working piece with at least one inorganic enamel or inorganic enamel-like carrier layer, said enamel or enamel-like material being compatible with the body; (b) converting said carrier layer into a viscous state; (c) incorporating the bio-active material particles into the viscous carrier layer to form a coating layer comprising a multitude of areas of bio-active material at least partially embedded into the carrier layer; and (d) causing the carrier layer to solidify. 2. The process of claim 1, in which several carrier layers of different composition and/or coefficient of expansion are applied to the prosthesis working piece.
3. The process of claim 1, in which the bio-active material particles are sprayed onto the carrier layer by gas pressure means.
4. The process of claim 1, in which the bio-active material particles are pressed into the carrier layer by mechanical pressure means.
5. The process of claim 1, in which a glass ceramic material is used as bio-active material.
6. The process of claim 1, in which bio-glass is used as bio-active material.
7. The process of claim 5, in which the starting materials yielding the glass ceramic material are at least partly used as bio-active material and are incorporated into the enamel carrier layer.
8. The process of claim 6, in which the starting materials for forming bio-glass are at least partly used as bio-active material and are incorporated into the enamel carrier layer.
9. The process of claim 1, in which the bio-active material in finely comminuted form is incorporated into the enamel carrier layer.
10. The process of claim 1, in which the depth of penetration of the bio-active material particles into the enamel carrier layer is varied by varying the pressure applied to said bio-active material particles and/or by varying the temperature-controlled viscosity of the enamel carrier layer.
11. The process of claim 1, in which the enamel carrier layer is applied to the prosthesis working piece by a process known in enamel technology, while the bio-active material particles are incorporated into the carrier layer at the same time while it is not completely solidified.
12. The process of claim 11, in which the enamel carrier layer is applied to the prosthesis working piece by means of a flame-spraying process or a plasma-spraying process.
13. The process of claim 1, in which the enamel carrier layer is applied to the prosthesis working piece by means of a process employed in enamel technology or by means of the flame-spraying process or the plasma-spraying process and in which the prosthesis working piece provided with the enamel carrier layer is subsequently heated to impart to the enamel carrier layer the viscosity required for incorporating the bio-active material particles thereinto.
14. The process of claim 13, in which the prosthesis working piece provided with the enamel carrier layer is heated by means of a flame and/or by heat radiation or in a heating oven in order to impart to the enamel carrier layer the viscosity required for incorporating the bio-active material particles.
15. The process of claim 13, in which the enamel carrier layer provided on a metallic prosthesis working piece is heated by induction or by directly conducting the electric current therethrough in order to impart to said enamel carrier layer the viscosity required for incorporating the bio-active material particles thereinto.
16. The process of claim 1, in which the surface of the solidified enamel carrier layer with the bio-active material particles incorporated thereinto is ground and/or polished.
The present invention relates to a process of providing metallic and non-metallic prosthesis parts with layers of bioactive material, to prosthesis parts coated according to said process, and to the use of such prosthesis parts for replacing animal and human bone.
Abnormal changes of and accidental injuries to bones and joints are remedied and eliminated at present by replacing the defective and damaged parts by prostheses made of inanimate materials which are foreign to the body, such as, for instance, metals, metal alloys, and plastic materials.
Recently, however, it has been found that metallic prosthesis parts which are anchored within the bone by means of plastic cements or adhesives, get loose after a certain period of time. Furthermore, frequently corrosion of the implanted materials has been observed. As a result thereof, for instance, hip-joint prostheses are implanted, at present, almost exclusively in elderly patients only because implantation surgery in younger patients has to be repeated from time to time.
According to German Auslegeschrift (application published for opposition) No. 23 06 552 corrosion can be avoided by selecting a suitable implant material or by coating the metallic prosthesis parts. However, even when proceeding in this manner, the prosthesis parts which are anchored within the bone still get loose. Thus there is a need for a new implant material which adheres firmly to its implant bed without requiring anchoring by means of a bone cement. It was believed that the oxidic ceramic materials (Al.sub.2 O.sub.3) of high strength properties represent such materials. However, the assumption that such oxidic ceramic materials grow readily together with the live bone, has not proved to be true. Although bones and tissue grow and adhere to the implant material and although bone substance is found also in the hollow spaces of the pores of an implant material having a porous surface, there has not been achieved a true complete union between bone and implanted prosthesis.
Although the oxidic ceramic materials possess no bio-activity, they represent an important raw material for producing implant parts. This is due to some of their properties such as, for instance, their high stability with respect to corrosive effects in the human organism and their high resistance to abrasion. This latter property represents an important parameter for the construction of moving parts of the body such as its joints. A joint implant which consists of a combination of metal or, respectively, metal alloy, which forms the shaft of the prosthesis, and of oxidic ceramic material which forms the ball and the socket of the joint has been disclosed in German Offenlegungsschrift (Published application) No. 21 34 316. However, both said prosthesis parts are not bio-active and thus render it rather difficult to effect implantation without the use of a bone cement.
Recently new materials which enter into intimate and firm connection with living bone tissue on account of their chemical composition and structure, have been developed. But these bio-active materials, for instance, bio-active glass ceramic material and bio-glass, do not have sufficiently high mechanical strength properties so that it is not possible to produce therefrom load-carrying prosthesis parts. When coating the heretofore known implant materials with such bio-active agents, it is possible to firmly anchor the same in the bone tissue without the additional use of bone cement.
Applying a layer of bio-active material to the prosthesis material according to known processes such as by spraying by the flame-spraying process or the plasma-spraying process, by dipping or by other methods, does not yield implant material of the required firmness of attachment and freedom from pores.
Furthermore, when the prosthesis material is coated in such a manner, there are encountered temperatures which, for instance, in the case of bio-active glass ceramic materials, partly destroy the cyrstallites which are responsible for growing together of the implant material and the bone tissue. To overcome this disadvantage, it was necessary to effect recrystallization of the glass ceramic material. For this purpose the coated implant part had again to be subjected to a heat treatment. However, temperatures of about 900 effect recrystallization, negatively affect the properties of metallic implant parts.
SUMMARY OF THE INVENTION It is one object of the present invention to provide a process of bio-activating prosthesis parts regardless which type of material is used for such parts, said parts being free of the disadvantages of the prior art prosthesis parts and having a satisfactory adhesive strength, being substantially free of pores, and not requiring high temperature treatment, said process yielding prosthesis parts of novel and highly advantageous properties especially of novel and advantageous surface properties.
Another object of the present invention is to provide prosthesis parts, their surfaces being of heretofore unknown quality and properties.
Another object of the present invention is to provide a method of using implant material as produced according to the novel process of this invention, for replacing bones and teeth and parts thereof in animals and humans.
In principle the process according to the present invention comprises the steps of
(a) first providing the prosthesis part with at least one enamel-like carrier layer compatible to the human or animal body,
(b) causing said carrier layer to attain a viscous condition,
(c) incorporating the bio-active material into the said carrier layer while in such viscous condition, and
(d) finally causing the thus bio-activated carrier layer to solidify.
According to a preferred embodiment of the present invention several enamel or enamel-like carrier layers of different composition and/or of different coefficient of expansion are applied to the prosthesis part. The bio-active materials can be applied to the carrier layer by spraying by means of air and/or gas under pressure. Or they can be pressed into the carrier layer by exerting mechanical pressure on the bio-active material dusted on or otherwise applied to the carrier layer.
Suitable bio-active materials are, for instance, glass ceramic materials and/or bio-glass. Preferred bio-active materials are those described, for instance, in U.S. Pat. No. 3,922,155.
The so-called bioglass is a material described, for instance, by L. L. Hench and H. A. Paschall in "Direct Chemical Bond of Bio-active Glass-Ceramic Materials to Bone and Muscle", Published in "Journ. Biomed. Mater. Res. Symposium" No. 4, 1973, pages 25 to 42.
In addition thereto, or even exclusively, there can be used the starting materials for producing such glass ceramic materials and/or bio-glass.
Preferably the bio-active coating materials are used in comminuted form. The particle size of the glass ceramic material may vary. Preferably the particle size is between about 50 μm. and about 250 μm.
Any known type of suitable prosthesis material can be used. Although not limited thereto, the following materials are mentioned:
(1) Metals, for instance:
Gold and/or platinum (see German Pat. No. 583,589);
Silver and/or tantalum (see German Pat. No. 23 26 100);
Titanium (see German Application Published For Opposition No. 21 38 881).
(2) Metal alloys, for instance:
Aluminum alloys such as Duralumin (see Ger. Publ. Appl. No. 23 59 826)
Titanium alloys (see German Published application No. 23 13 678);
Cobalt-chromium-molybdenum alloys such as the alloy sold under the trademark Vitallium (see also German Published application No. 23 13 678) by the firm Howmedico;
Chromium-nickel-molybdenum alloys (see German Published application No. 23 13 678);
Cobalt-nickel-chromium alloys (see German Published application No. 23 13 678).
(3) Oxidic ceramic material, such as
Sintered aluminum oxide (German Published application No. 21 34 316);
Zirconium dioxide and/or titanium dioxide (see German Published application No. 23 18 459).
(4) Pyrolytic carbon, such as
Graphite (see U.S. Pat. No. 3,526,005).
Of course, any known prosthesis material as used heretofore can be improved according to the present invention. Combinations of such materials, for instance, of a prosthesis core of metal and/or metal alloys and of a prosthesis casing or shell of oxidic ceramic material and/or pyrolytic carbon and others, can also be employed.
Reference is also made to the book on "Metallische Implantate in der Knochenchirurgie" [in translation: Metallic Implants In Bone Surgery] by E. Frank and H. Zitter, published by Springer, Vienna 1971.
Numerous enamel materials compatible with the human or animal body can be employed as carrier material. Enamels as described in German Application Published for Opposition No. 12 91 597 have proved to be especially useful. See also the enamels as described in the publication of the Borax Consolidated Ltd., London (1965) on "Enamels". Of course, lead oxide and other oxides or components which are harmful to the human or animal body should not be present in the carrier enamel layer. B.sub.2 O.sub.3 and Li.sub.2 O should be present not more than 5% by weight.
The depth of penetration of the bio-active material into the carrier layer can be varied by varying the pressure employed for spraying the same onto the carrier layer and/or by varying the viscosity of the carrier layer. The carrier layer may be applied to the prosthesis part by processes known in enamelling technology. The bio-active material can be introduced into the carrier layer at the same time while the enamel carrier layer has not completely solidified.
It is also possible to apply the carrier layer to the prosthesis parts by means of the flame-spraying process or the plasma-spraying process and to introduce the bio-active material into the carrier layer at the same time while not yet solidified.
The carrier layer alone can also be applied to the prosthesis parts by the conventional processes as employed in enamel technology or by flame-spraying or by plasma-spraying. The prosthesis part provided with the carrier layer is heated subsequently so as to convert the carrier layer into a fluid layer of the viscosity required for incorporating the bio-active material.
The required viscosity of the carrier layer can also be attained by heating the prosthesis part with the enamel layer by means of a flame and/or by radiation, by placing both in a heating oven, by induction heating, or by passing the electric current directly therethrough.
The surface of the solidified carrier layer with the bio-active material incorporated thereinto can subsequently be ground and/or polished.
A prosthesis part produced according to the present invention is distinguished over heretofore known prosthesis parts by being provided with at least one enamel or enamel-like carrier layer which is compatible to the body and wherein the bio-active material is wholly or partly embedded. In a specific embodiment of the present invention the bio-active material particles protrude from the surface of the carrier layer while in another embodiment the surface of the carrier layer with the bio-active material embedded therein is smoothly ground and/or polished.
BRIEF DESCRIPTION OF THE DRAWINGS Examples of prosthesis parts obtained according to the present invention are diagrammatically illustrated in the attached drawings in which
FIG. 1 is a cross-sectional view of a prosthesis part coated according to the present invention;
FIG. 2 is a cross-sectional view of such a prosthesis part with a polished surface; and
FIG. 3 is a top view of the surface illustrated in FIG. 2.
DESCRIPTION OF THE PREFERRED EMBODIMENTS As stated above, the prosthesis part 10 as shown in FIG. 1 can be made of a suitable metal, of oxidic ceramic material or of other materials. Its surface is cleaned and pretreated in a manner known per se so that a substantially clean surface as provided. The carrier layer 11 is then applied to the thus pretreated surface of the prosthesis part by enamelling procedures as they are known to the art. Said carrier layer consists of a non-toxic enamel or enamel-like material which is compatible to tbe body.
As mentioned hereinabove, preferred enamel or enamel-like materials are those described in German Application Published For Opposition No. 12 91 597, wherein it is disclosed in which manner its composition can be adjusted to any type of metallic base and to meet any desired requirements regarding corrosion resistance, adhesive strength, and coefficient of expansion. The composition of the enamel layer is not an object of the present invention.
As explained hereinabove, all the known processes of applying enamel compositions to a base, for instance, the wet process, the dry process, the electrophoretic process, the flame-spraying process, or the plasma-spraying process can be used for enamelling the prosthesis parts. The carrier layer 11 may be applied as a single layer; but it may also be applied in several layers which may be of different composition and thus may have different coefficients of expansion.
The bio-active material 12 which, for instance, is in comminuted form, is incorporated into the carrier layer 11 while said layer is still in soft condition, for instance, by spraying it thereon by means of an air and/or gas blast.
The depth to which the individual particles of the bio-active material 12 penetrate into the enamel layer depends on the viscosity of said layer 11. Additionally it can be varied by varying the pressure of the gas and/or air blast. The thickness of the bio-active layer is regulated by the amount of bio-active material 12 which is carried along by the air and/or gas blast. Said amounts of bio-active material can be varied so that they increase progressively from the interior of the carrier layer towards its surface by automatically regulating the air and/or gas blast and the amount of the bio-active material supplied.
Of course, the bio-active material 12 can be introduced into and/or upon the carrier layer by means of other processes, for instance, by pressing the bio-active material 12 into the enamelled layer by means of a mold fitting the prosthesis working piece.
It is understood that the bio-active material 12 need not be introduced into the carrier layer 11 according to the above described processes simultaneously with and/or directly subsequently to the application of said carrier layer 11. Working piece 10 can first be coated with the enamel carrier layer 11 and can be treated in a subsequent step of operation at any desired time so as to apply thereto the bio-active material 12.
In order to proceed in the last mentioned manner it is necessary that the prosthesis working piece 10 coated with a carrier layer 11 is subjected subsequently to such a heat treatment that a viscous state of a viscosity permitting incorporation of the bio-active material is imparted to the carrier layer 11.
Reheating of the enamel-coated working piece can be effected, for instance, by an open flame and/or heat radiation or by placing it in a heating oven, and, in the case of metallic prosthesis working pieces, by induction heating and/or by passing an electric current directly therethrough.
The advantages of the novel process according to the present invention are to be seen in the use of methods which are well known to the art and can be controlled readily in accordance with known manufacturing techniques.
In contrast to the known multi-layer coating process in which the individual layers are superposed and in which each layer per se forms a completely or almost completely self-contained layer, the bio-active material is incorporated according to the process of the present invention into the carrier layer in such a manner that the bio-active particles are completely and/or partly embedded in the carrier layer and that they also adhere to the surface of said layer. As a result thereof the prosthesis working piece grows readily together with the body tissue even if the layer of bio-active material is not a completely continuous layer. Since the carrier layer covers the prosthesis working piece completely, the material for the prosthesis can be selected, for instance, solely according to the required strength.
The embodiment of the present invention as illustrated in FIG. 1 in which the enamel layer is coated with particles of bio-active material which partly protrude from the carrier layer has the advantage that a very large surface is formed and that, for instance, the bone tissue can readily grow unto said surface.
However, under certain conditions of use, it can be of advantage that the coated prosthesis working piece is provided with a smooth surface. In this case the surface of bio-active material coated prosthesis parts can be ground and/or polished as this is illustrated in FIG. 2. The smooth surface of such a coated prosthesis working piece is provided, depending on the density of the bio-active material particles incorporated into the enamel layer, with a multitude of elementary areas of bio-active material on which growing together of the prosthesis with the body tissue can take place. FIG. 3 illustrates the smooth surface in which the bio-active particles are shown.
The following examples serve to illustrate the present invention and more particularly suitable compositions of the prosthesis, the enamel layer, and the bio-active material without, however, limiting the same thereto.
EXAMPLE 1 A hip-thigh joint prosthesis according to the present invention is produced by first enamelling suitably shaped pieces of a cobalt-chromium-molybdenum alloy by any of the known enamelling methods with the following enamel composition, in parts by weight:
______________________________________Silicon dioxide   (SiO.sub.2)                       61.0Boron trioxide    (B.sub.2 0.sub.3)                       4.7Lithium oxide     (Li.sub.2 0)                       0.9Sodium oxide      (Na.sub.2 0)                       16.7Magnesium oxide   (MgO)     4.7Titanium dioxide  (TiO.sub.2)                       10.8Cryolite          (Na.sub.3 A1F.sub.6)                       1.2______________________________________
After providing the prosthesis core part with an enamel layer of about 0.3 mm. thickness, the resulting enamelled prosthesis is heated to a temperature of about 680 softened viscous consistency.
A bio-active material of the following composition, in weight %, is finely comminuted to a particle size between about 100 μm. and about 175 μm:
______________________________________Component   a      b      c    d    e    f     g______________________________________SiO.sub.2   46.2   43.0   43.0 43.0 46.0 45.0 43.0Ca.sub.3 (PO.sub.4).sub.2       25.5   21.0   21.0 21.0 --   --   21.0Ca(PO.sub.3).sub.2       --     --     --   --   13.4 13.9 --CaO         20.2   15.0   11.8 11.0 18.6 1.1  10.0MgO         2.9    8.0    11.5 11.5 11.5 30.0 10.5Na.sub.2 O  4.8    12.0   5.9  5.7  5.7  5.0  5.7K.sub.2 O   0.4    1.0    6.8  6.8  3.8  5.0  6.8CaF.sub.2   --     --     --   1.0  1.0  --   2.0______________________________________
The particles of bio-active material are then sprayed upon the softened, viscous enamel layer of the prosthesis so that they penetrate into said layer and are incorporated thereinto. Some of the particles protrude to a certain extent from the surface of the prosthesis as shown in FIG. 1. After cooling and solidifying the enamel layer the resultant prosthesis is finely ground and polished to yield a smooth surface as shown in FIGS. 2 and 3.
The resulting prosthesis is implanted surgically into the patient and readily grows into the hip and other bone tissue. Such prostheses have proved to replace joints which are diseased or which are painful, such as the hip joint, the elbow joint, the shoulder joint, or finger joints. For instance, the head, neck, and part of the shaft of the femur may be replaced by arthroplasty by the correspondingly shaped prosthesis parts according to the present invention. The crushed lower part of a humerus, i.e. the upper bone in the elbow or the upper part of the humerus connecting to the shoulder have also been surgically replaced successfully by correspondingly shaped prosthesis parts according to the present invention.
Of course, many changes and variations in the composition of the bio-active material, the enamel carrier layer, and the prosthesis core material, in the manner in which the prosthesis core material is enamelled and the bio-active material is incorporated into the enamel carrier layer, and the like may be made by those skilled in the art in accordance with the principles set forth herein and in the claims annexed hereto.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3919723 *May 20, 1974Nov 18, 1975Friedrichsfeld GmbhBone shaft or bone joint prosthesis and process* Cited by examinerNon-Patent CitationsReference1 *Biological Activity & Histo compatiblity of Dense Al.sub.2 O.sub.3 /MgO Ceramic Implants, J. Biomed.2 *Direct Chem. of Bioactive Glass- Ceramic Materials to Bone & Muscle-J. Biomed. Mat. Symposium (1973) Chem. Abstract - 85-166538m.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS4617024 *Nov 28, 1983Oct 14, 1986Ernst Leitz Wetzlar GmbhAuditory ossicle prosthesis and process for its manufactureUS4714473 *Jul 25, 1985Dec 22, 1987Harrington Arthritis Research CenterKnee prosthesisUS4722870 *Jan 22, 1985Feb 2, 1988Interpore InternationalMetal-ceramic composite material useful for implant devicesUS4728335 *Dec 15, 1986Mar 1, 1988Jurgutis John AHip prosthesisUS4795475 *Aug 9, 1985Jan 3, 1989Walker Michael MProsthesis utilizing salt-forming oxyacids for bone fixationUS4878914 *Jul 1, 1988Nov 7, 1989Kyocera CorporationCeramic prosthesis for living body & method of making the sameUS4950294 *May 2, 1988Aug 21, 1990Olympus Optical Co., Ltd.Composite structure useful as artificial bonesUS4964868 *Aug 27, 1987Oct 23, 1990Harrington Arthritis Research CenterKnee prosthesisUS5061286 *Aug 18, 1989Oct 29, 1991Osteotech, Inc.Osteoprosthetic implantUS5296254 *Jun 8, 1992Mar 22, 1994Bestex Kabushiki-KaishaMethod of producing a filtering materialUS5597619 *Apr 10, 1995Jan 28, 1997Bestex Kabushiki-KaishaFiltering material and method of producing the sameUS5658333 *May 9, 1996Aug 19, 1997Depuy, Inc.Prosthesis with highly convoluted surfaceUS5665121 *Feb 29, 1996Sep 9, 1997Howmedica InternationalPreformed mantleUS5741253 *Oct 29, 1992Apr 21, 1998Michelson; Gary KarlinMethod for inserting spinal implantsUS5772661 *Feb 27, 1995Jun 30, 1998Michelson; Gary KarlinMethods and instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the antero-lateral aspect of the spineUS5797909 *Jun 7, 1995Aug 25, 1998Michelson; Gary KarlinApparatus for inserting spinal implantsUS5990380 *Oct 10, 1997Nov 23, 1999University Of Florida Research Foundation, Inc.Percutaneous biofixed medical implantsUS6008432 *Oct 1, 1997Dec 28, 1999Osteonics Corp.Metallic texture coated prosthetic implantsUS6096038 *Jun 7, 1995Aug 1, 2000Michelson; Gary KarlinApparatus for inserting spinal implantsUS6120502 *May 27, 1994Sep 19, 2000Michelson; Gary KarlinApparatus and method for the delivery of electrical current for interbody spinal arthrodesisUS6123705 *Oct 1, 1996Sep 26, 2000Sdgi Holdings, Inc.Interbody spinal fusion implantsUS6149650 *May 8, 1998Nov 21, 2000Michelson; Gary KarlinThreaded spinal implantUS6210412Jun 7, 1995Apr 3, 2001Gary Karlin MichelsonMethod for inserting frusto-conical interbody spinal fusion implantsUS6224595Apr 20, 1998May 1, 2001Sofamor Danek Holdings, Inc.Method for inserting a spinal implantUS6264656May 8, 1998Jul 24, 2001Gary Karlin MichelsonThreaded spinal implantUS6270498Jun 7, 1995Aug 7, 2001Gary Karlin MichelsonApparatus for inserting spinal implantsUS6299930Sep 20, 1999Oct 9, 2001Usbiomaterials Corp.Percutaneous biofixed medical implantsUS6527810Dec 21, 2000Mar 4, 2003Wright Medical Technology, Inc.Bone substitutesUS6605089Sep 23, 1999Aug 12, 2003Gary Karlin MichelsonApparatus and method for the delivery of electrical current for interbody spinal arthrodesisUS6682567 *Sep 19, 2001Jan 27, 2004Biomet, Inc.Method and apparatus for providing a shell component incorporating a porous ingrowth material and linerUS6758849Aug 18, 2000Jul 6, 2004Sdgi Holdings, Inc.Interbody spinal fusion implantsUS6770074Nov 17, 2001Aug 3, 2004Gary Karlin MichelsonApparatus for use in inserting spinal implantsUS6875213Feb 21, 2003Apr 5, 2005Sdgi Holdings, Inc.Method of inserting spinal implants with the use of imagingUS6923810Jun 7, 1995Aug 2, 2005Gary Karlin MichelsonFrusto-conical interbody spinal fusion implantsUS6977095Nov 15, 1999Dec 20, 2005Wright Medical Technology Inc.Process for producing rigid reticulated articlesUS7207991Mar 18, 2002Apr 24, 2007Warsaw Orthopedic, Inc.Method for the endoscopic correction of spinal diseaseUS7250550Oct 22, 2004Jul 31, 2007Wright Medical Technology, Inc.Synthetic bone substitute materialUS7255698Aug 11, 2003Aug 14, 2007Warsaw Orthopedic, Inc.Apparatus and method for anterior spinal stabilizationUS7264622Oct 24, 2003Sep 4, 2007Warsaw Orthopedic, Inc.System for radial bone displacementUS7291149Oct 4, 1999Nov 6, 2007Warsaw Orthopedic, Inc.Method for inserting interbody spinal fusion implantsUS7326214Aug 9, 2003Feb 5, 2008Warsaw Orthopedic, Inc.Bone cutting device having a cutting edge with a non-extending centerUS7399303Aug 20, 2002Jul 15, 2008Warsaw Orthopedic, Inc.Bone cutting device and method for use thereofUS7431722Jun 6, 2000Oct 7, 2008Warsaw Orthopedic, Inc.Apparatus including a guard member having a passage with a non-circular cross section for providing protected access to the spineUS7452359Jun 7, 1995Nov 18, 2008Warsaw Orthopedic, Inc.Apparatus for inserting spinal implantsUS7455672Jul 31, 2003Nov 25, 2008Gary Karlin MichelsonMethod for the delivery of electrical current to promote bone growth between adjacent bone massesUS7491205Jun 7, 1995Feb 17, 2009Warsaw Orthopedic, Inc.Instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the lateral aspect of the spineUS7534254Jun 7, 1995May 19, 2009Warsaw Orthopedic, Inc.Threaded frusto-conical interbody spinal fusion implantsUS7569054Nov 8, 2005Aug 4, 2009Warsaw Orthopedic, Inc.Tubular member having a passage and opposed bone contacting extensionsUS7597715Feb 17, 2006Oct 6, 2009Biomet Manufacturing Corp.Method and apparatus for use of porous implantsUS7621963Apr 11, 2006Nov 24, 2009Ebi, LlcComposite bone graft materialUS7635447Feb 17, 2006Dec 22, 2009Biomet Manufacturing Corp.Method and apparatus for forming porous metal implantsUS7686805Jul 1, 2004Mar 30, 2010Warsaw Orthopedic, Inc.Methods for distraction of a disc spaceUS7691148Mar 19, 2005Apr 6, 2010Warsaw Orthopedic, Inc.Frusto-conical spinal implantUS7722619Apr 25, 2006May 25, 2010Warsaw Orthopedic, Inc.Method of maintaining distraction of a spinal disc spaceUS7740897Oct 6, 2005Jun 22, 2010Wright Medical Technology, Inc.Process for producing rigid reticulated articlesUS7754246Sep 8, 2006Jul 13, 2010Wright Medical Technology, Inc.Composite bone graft substitute cement and articles produced therefromUS7766972Jul 2, 2007Aug 3, 2010Wright Medical Technology, Inc.Synthetic, malleable bone graft substitute materialUS7789914Aug 26, 2004Sep 7, 2010Warsaw Orthopedic, Inc.Implant having arcuate upper and lower bearing surfaces along a longitudinal axisUS7828800May 18, 2009Nov 9, 2010Warsaw Orthopedic, Inc.Threaded frusto-conical interbody spinal fusion implantsUS7887565Feb 18, 2006Feb 15, 2011Warsaw Orthopedic, Inc.Apparatus and method for sequential distractionUS7914530Apr 25, 2006Mar 29, 2011Warsaw Orthopedic, Inc.Tissue dilator and method for performing a spinal procedureUS7914554Mar 15, 2002Mar 29, 2011Warsaw Orthopedic, Inc.Spinal implant containing multiple bone growth promoting materialsUS7935116Nov 25, 2008May 3, 2011Gary Karlin MichelsonImplant for the delivery of electrical current to promote bone growth between adjacent bone massesUS7942933Apr 3, 2010May 17, 2011Warsaw Orthopedic, Inc.Frusto-conical spinal implantUS7976566Mar 25, 2002Jul 12, 2011Warsaw Orthopedic, Inc.Apparatus for insertion into an implantation spaceUS7993347Jul 27, 2000Aug 9, 2011Warsaw Orthopedic, Inc.Guard for use in performing human interbody spinal surgeryUS8021430Sep 7, 2010Sep 20, 2011Warsaw Orthopedic, Inc.Anatomic spinal implant having anatomic bearing surfacesUS8021432Oct 11, 2006Sep 20, 2011Biomet Manufacturing Corp.Apparatus for use of porous implantsUS8025903Feb 13, 2007Sep 27, 2011Wright Medical Technology, Inc.Composite bone graft substitute cement and articles produced therefromUS8057475Nov 9, 2010Nov 15, 2011Warsaw Orthopedic, Inc.Threaded interbody spinal fusion implantUS8066705Feb 21, 2003Nov 29, 2011Warsaw Orthopedic, Inc.Instrumentation for the endoscopic correction of spinal diseaseUS8066778Feb 22, 2007Nov 29, 2011Biomet Manufacturing Corp.Porous metal cup with cobalt bearing surfaceUS8123814Jun 26, 2007Feb 28, 2012Biomet Manufacturing Corp.Method and appartus for acetabular reconstructionUS8197550Sep 14, 2009Jun 12, 2012Biomet Manufacturing Corp.Method and apparatus for use of porous implantsUS8206387Apr 21, 2011Jun 26, 2012Gary Karlin MichelsonInterbody spinal implant inductively coupled to an external power supplyUS8226652Nov 14, 2011Jul 24, 2012Warsaw Orthopedic, Inc.Threaded frusto-conical spinal implantsUS8251997Nov 29, 2011Aug 28, 2012Warsaw Orthopedic, Inc.Method for inserting an artificial implant between two adjacent vertebrae along a coronal planeUS8266780Feb 27, 2008Sep 18, 2012Biomet Manufacturing Corp.Method and apparatus for use of porous implantsUS8292967Dec 5, 2005Oct 23, 2012Biomet Manufacturing Corp.Method and apparatus for use of porous implantsUS8343188Apr 23, 2012Jan 1, 2013Warsaw Orthopedic, Inc.Device and method for locking a screw with a bendable plate portionUS8353909Apr 25, 2006Jan 15, 2013Warsaw Orthopedic, Inc.Surgical instrument for distracting a spinal disc spaceUS8353959Apr 23, 2012Jan 15, 2013Warsaw Orthopedic, Inc.Push-in interbody spinal fusion implants for use with self-locking screwsUS8403986May 9, 2006Mar 26, 2013Warsaw Orthopedic, Inc.Push-in interbody spinal fusion implant with multi-lock for locking opposed screws and method for use thereofUS8409292May 17, 2011Apr 2, 2013Warsaw Orthopedic, Inc.Spinal fusion implantUS8444696Sep 19, 2011May 21, 2013Warsaw Orthopedic, Inc.Anatomic spinal implant having anatomic bearing surfacesUS8551181Feb 27, 2012Oct 8, 2013Biomet Manufacturing, LlcMethod and apparatus for acetabular reconstruction* Cited by examinerClassifications U.S. Classification427/2.24, 623/923, 427/2.27International ClassificationA61L27/30, A61F2/28, C04B41/86, A61F2/30, C23D5/00, A61L27/00, C04B41/50, A61F2/00Cooperative ClassificationA61F2310/00203, C04B41/86, C23D5/00, C04B41/5022, A61F2310/00011, A61F2310/00928, A61L27/306, A61F2310/00934, A61F2/30767, Y10S623/923, A61F2310/00592, A61F2002/30037, A61F2002/30929, A61L27/30European ClassificationA61L27/30, A61F2/30L, C23D5/00, C04B41/50M, C04B41/86, A61L27/30RRotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google