Source: http://www.google.com/patents/US8216610?dq=5343970
Timestamp: 2013-12-21 04:06:32
Document Index: 171921659

Matched Legal Cases: ['Application No. 60', 'Application No. 20040204475', 'Application No. 20040170681', 'art 1', 'art 2', 'art 1', 'art 1', 'art 1', 'art 1', 'Application No. 20040170681', 'Application No. 20040204475']

Patent US8216610 - Oral paracetamol formulations - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe present invention relates generally to formulations comprising paracetamol. More particularly, the present invention provides a swallow formulation comprising paracetamol which facilitates the rapid delivery of paracetamol into the circulatory system following oral administration. The present invention...http://www.google.com/patents/US8216610?utm_source=gb-gplus-sharePatent US8216610 - Oral paracetamol formulationsAdvanced Patent SearchPublication numberUS8216610 B2Publication typeGrantApplication numberUS 11/604,972Publication dateJul 10, 2012Filing dateNov 27, 2006Priority dateMay 28, 2004Also published asUS20070141144Publication number11604972, 604972, US 8216610 B2, US 8216610B2, US-B2-8216610, US8216610 B2, US8216610B2InventorsMichael Stephen Roberts, Ruoying Jiang, Keivan Bezanehtak, Greg Andrew Davey, George Alexander Davidson, Geraldine Ann Elliott, Stephen Douglas Chandler, Mantu SarkarOriginal AssigneeImaginot Pty Ltd.Export CitationBiBTeX, EndNote, RefManPatent Citations (105), Non-Patent Citations (39), Classifications (18), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetOral paracetamol formulationsUS 8216610 B2Abstract The present invention relates generally to formulations comprising paracetamol. More particularly, the present invention provides a swallow formulation comprising paracetamol which facilitates the rapid delivery of paracetamol into the circulatory system following oral administration. The present invention further relates to methods for inducing efficient pain relief including an analgesic effect by the administration of the paracetamol formulation.
1. A swallow formulation comprising paracetamol particles having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2g−1, a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake into the formulation; wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C., wherein the weight ratio of the paracetamol and the pH modulating agent is between 1.8:1 and 2.5:1 and the weight ratio of the agent which facilitates water uptake into the formulation and the pH modulating agent is between 0.5:1 and 1.5:1.
2. A swallow formulation comprising paracetamol particles having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2g−1, a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake into the formulation; wherein at least one pH modulating agent is a carbonate in an amount that will neutralise 0.01 to 9.0 millimoles of hydrochloric acid and is present in an amount from about 1% to 50% by weight of the swallow formulation; wherein at least about 5% of the paracetamol is dissolved from the swallow formulation within 300 seconds at 0 rpm when the dissolution is measured in United States Pharmacopoeia (USP) dissolution apparatus 2 with 900 mL 0.0033 N hydrochloric acid at 37� C., wherein the weight ratio of the paracetamol and the pH modulating agent is between 1.8:1 and 2.5:1 and the weight ratio of the agent which facilitates water uptake into the formulation and the pH modulating agent is between 0.5:1 and 1.5:1.
3. A swallow formulation comprising paracetamol particles having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1, a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake into the formulation;
(a) at least about 5% of the paracetamol is dissolved from the swallow formulation within 300 seconds at 0 rpm, and
(b) at least about 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds at 30 rpm,
when the dissolution is measured in United States Pharmacopoeia (USP) dissolution apparatus 2 with 900 mL 0.0033 N hydrochloric acid at 37� C., wherein the weight ratio of the paracetamol and the pH modulating agent is between 1.8:1 and 2.5:1 and the weight ratio of the agent which facilitates water uptake into the formulation and the pH modulating agent is between 0.5:1 and 1.5:1.
4. The swallow formulation of claim 1, wherein at least 80% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
5. The swallow formulation of claims 2 or 3 wherein the swallow formulation is a tablet and at least 20% of the paracetamol is dissolved from the swallow formulation within 300 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 0 rpm and 37� C.
6. The swallow formulation of claim 1, wherein at least 80% of the paracetamol is dissolved from the swallow formulation within 120 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
7. The swallow formulation of claim 1, wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 90 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
8. The swallow formulation of claim 1, wherein at least 80% of the paracetamol is dissolved from the swallow formulation within 90 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
9. The swallow formulation of any one of claims 1 to 3 wherein a single dose administration of 1000 mg paracetamol with water in fasted healthy human subjects provides a mean AUC20 of more than about 150 min�mg�L−1.
10. The swallow formulation of claim 1, wherein a single dose administration of 1000 mg paracetamol with water in fasted healthy human subjects provides a mean AUC20 of more than about 170 min�mg�L−1.
11. The swallow formulation of claim 1, wherein the paracetamol in the formulation exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds.
12. The swallow formulation of any one of claims 1 to 3 wherein the pH modulating agent is soluble and/or dispersible.
13. The swallow formulation of claim 1, wherein at least one pH modulating agent is a base.
14. The swallow formulation of claim 13, wherein at least one pH modulating agent is a carbonate.
15. The swallow formulation of claim 14, wherein the carbonate is selected from the group consisting of sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate, sodium carbonate, ammonium carbonate, disodium glycine carbonate, sodium glycine carbonate, lysine carbonate and arginine carbonate.
16. The swallow formulation of claim 15, wherein the carbonate is water soluble.
17. The swallow formulation of claim 16, wherein the carbonate is a sodium carbonate.
18. The swallow formulation of any one of claims 1, 2, or 3, wherein the amount of paracetamol dissolved from the swallow formulation is at least about 5 times greater than the amount of rapidly dissolving paracetamol dissolved from a swallow formulation without a carbonate pH modulating agent after 30 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
19. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol has a volume median diameter (D50) less than about 300 μm.
20. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol has a surface area to mass ratio greater than about 0.08 m2g−1.
21. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol is the product of paracetamol crystallized in the presence of one or more crystallization modifiers.
22. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol has been crystallized in the presence of a crystal modifier chosen from the group consisting of polymers, proteins or mixture thereof.
23. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol has been crystallized in the presence of polyvinylpyrrolidone.
24. The swallow formulation of claim 1, wherein the paracetamol is in the form of granules.
25. The swallow formulation of any one of claims 1, 2, or 3, wherein the paracetamol is in the form of granules including an agent chosen from the group consisting of pH modulating agents, water uptake agents and mixtures thereof.
26. The swallow formulation of any one of claims 1, 2, or 3, comprising at least one of extra granular paracetamol, pH modulating agent, or water uptake agent.
27. The swallow formulation of claim 24, wherein the granules further comprise a disintegrant.
28. The swallow formulation of claim 27, wherein the disintegrant is chosen from the group consisting of crospovidone, croscarmellose, sodium starch glycolate, starch, starch derivative and mixtures thereof.
29. The swallow formulation of claims 1, 2, or 3, wherein the agent which facilitates water uptake into the formulation is selected from the group consisting of cross-linked polyvinylpyrrolidone (crospovidone), croscarmellose sodium, sodium starch glycolate, povidone, starch, starch derivatives, low substituted hydroxypropylcellulose, hydroxypropylcellulose, alginic acid, sodium alginate, calcium sulfate, calcium carboxymethylcellulose, microcrystalline cellulose, powdered cellulose, colloidal silicon dioxide, docusate sodium, guar gum, magnesium aluminium silicate, methylcellulose, polacrilin potassium, silicified microcrystalline cellulose, magnesium oxide, tragacanth, mannitol, sorbitol, xylitol, sucrose, lactose, fructose, maltose, polyethylene glycol, aminoacids, cyclodextrin, urea and polyvinylpyrrolidone.
30. The swallow formulation of claims 1, 2, or 3, further comprising one or more other pharmaceutically active agents.
31. The swallow formulation of claim 1, wherein the swallow formulation comprises paracetamol in an amount ranging from 100 mg to 1000 mg, and pH modulating agent in an amount sufficient to neutralize from about 0.3 mL to about 55 mL 0.1N hydrochloric acid and/or to neutralize from about 0.03 mmol to about 5.5 mmol of acid.
32. A dosage form comprising the swallow formulation of claims 1, 2 or 3.
33. A dosage form comprising the swallow formulation of claims 1, 2, or 3, wherein the dosage form is a coated tablet, uncoated tablet, capsule or powder.
34. A dosage form comprising a swallow formulation claims 1, 2, or 3, and selected from the group consisting of coated tablets, uncoated tablets, capsules and powders which further comprises one or more pharmaceutically active agents.
35. A dosage form comprising the swallow formulation of claims 1, 2, or 3, and selected from the group consisting of coated tablets, uncoated tablets, capsules and powders which dosage form comprises a further pharmaceutically active agents comprising paracetamol and wherein the dosage form exhibits dissolution in USP dissolution apparatus 2 using 900 mL of 0.05 N HCl with the paddle spinning at 30 rpm at 37� C. of less than 30% in 180 seconds.
36. A method for the treatment of symptoms chosen from the group consisting of pain, fever, discomfort or combinations thereof in a subject, said method comprising administering to said subject the swallow formulation of any one of claims 1, 2, or 3.
37. A method for the treatment of symptoms chosen from the group consisting of pain, fever, discomfort or combinations thereof and wherein the symptoms are exhibited by a human and the method comprises administering to the human the swallow formulation of any one of claims 1, 2, or 3.
38. The swallow formulation according to claim 30, wherein said one or more other pharmaceutically active agent is an analgesic.
39. The swallow formulation according to claim 38, wherein said analgesic is tramadol.
40. The swallow formulation of claim 15, wherein the carbonate is sodium bicarbonate.
RELATED APPLICATIONS This application is a continuation-in-part of U.S. patent application Ser. No. 11/138,262, filed May 27, 2005, now abandoned, which claims priority of U.S. Provisional Patent Application No. 60/575,477, filed May 28, 2004.
The present invention relates generally to formulations comprising paracetamol. More particularly, the present invention provides a swallow formulation comprising paracetamol which facilitates the rapid delivery of paracetamol into the circulatory system following oral administration. The present invention further relates to methods for inducing efficient pain relief including an analgesic effect by the administration of the paracetamol formulation.
Paracetamol, also known as N-acetyl-p-aminophenol, acetaminophen and APAP, is an analgesic and antipyretic agent and is widely used in prescription and non-prescription medicines. Paracetamol was first marketed in the 1950's and is now a commonly used agent (Prescott Am. J. Ther. 7(2):143-147 2000). The precise mechanism of paracetamol's analgesic and antipyretic effect remains unclear. However, some studies have suggested that the rate of administration is a factor (Nielsen et al. Eur. J. Clin. Pharmacol. 42(3): 261-264, 1992, Luthy, et al. Schweiz Med. Wochenschr 123 (Suppl 50)/II:406, 1993). Accordingly, increasing the rate of absorption of paracetamol should enable a greater and more rapid analgesic effect after oral dosing. In this regard, oral delivery is the most convenient and acceptable route of drug administration to end users, especially for a drug administered at high doses and frequency, such as paracetamol.
Improving the rate and extent of absorption of oral formulations of compounds has been the subject of substantial research. In general, once a solid swallow composition reaches the stomach, it undergoes disintegration and/or dissolution and passes into the small intestine where the active ingredient is absorbed across intestinal walls into the circulatory system via the portal vein and liver before reaching the site of action.
Rates of absorption are often assessed by comparing standard pharmacokinetic parameters such as the time to peak plasma concentration (Tmax) and the peak plasma concentration (Cmax). The extent of absorption is assessed by the area under the plasma concentration-time curve (AUC). A short Tmax has been used to indicate rapid absorption. The FDA Guidance for Industry on Bioavailability and Bioequivalence Studies for Orally Administered Products (2003) and related publications (Chen et al, Clin. Pharmacokinet. 40(8):565-72, 2001) recommend the use of partial AUC as an early exposure measure, such that a high partial AUC will be an indicator of rapid absorption. The parameters for known formulations vary greatly between subjects. The parameters also vary depending on aspects of the study protocol such as the sampling scheduling, subject posture and general subject health. Values quoted in this specification are given as mean�standard deviation unless otherwise noted.
For paracetamol tablets supplied by McNeil, a Tmax value has been quoted as 45.6 minutes with a standard error of 7.2 minutes with a corresponding Cmax value of 11.99 mg�L−1 with a standard error of 1.02 (Ameer et al., J. Pharm. Sci, 72:955-958, 1983)). Other values quoted include a Tmax of 35.6�27.7 minutes and Cmax of 9.47�4.18 mg�L−1 (Rumble et al., Clin. Pharmacokinet. 20 (2): 167-173, 1991), a Tmax of 1.82 hours with a standard error of 0.46 hours and a Cmax of 20.4�3.2 mg�L−1 for Paralen tablets and for Panadol tablets, a Tmax of 35 minutes and as high as 77 minutes and a Cmax value of 17.02�6.04 mg�L−1 (Grattan et al., Eur. J Pharm. Biopharm. 49(3):225-229, 2000).
The range of paracetamol plasma concentrations for e effective analgesia in humans is quoted to be about 5-20 μg�mL−1. (Prescott, Medical Clinics of North America, 58:907-916, 1974). For antipyresis a paracetamol concentration of 10-20 μg�mL−1 has been shown to be effective (Rumack et al, Pediatrics 62(Suppl):898-903, 1978).
In a submission compiled by McNeil in 2002 in relation to Tylenol to demonstrate safety and efficacy of paracetamol to the United States Food and Drug Administration (USFDA), the effective concentration which elicits 50% of the maximum drug response (EC50) was estimated to be between 15.2 μg�mL−1 and 16.55 μg�mL−1 (McNeil submission to FDA, 2002)
Prescott (1974, supra) reported there may be as much as an 80-fold range in concentrations 1 hour after therapeutic doses of paracetamol were administered in 43 patients. He concluded that pharmacokinetic variability impacts on response rates for analgesics. In fact, many patients may never achieve a therapeutic effect.
In U.S. Pat. No. 6,316,025, Grattan describes a swallow tablet of paracetamol containing 300 mg to 1000 mg of sodium bicarbonate per tablet and a paracetamol to sodium bicarbonate ratio of between 0.74 and 1. Grattan et al. (2000 supra) subsequently reported that a formulation with 630 mg sodium bicarbonate gave a Tmax of 17.5�4.95 minutes and a Cmax of 29.79�9.06 mg�L−1. It was suggested that this was due to an osmotic effect of sodium bicarbonate, which would be isotonic when ingested with 100 mL of water.
US Patent Application No. 20040204475 describes a formulation containing sodium bicarbonate and eletriptan. The sodium bicarbonate is administered in an amount to obtain a duodenal concentration approximately isotonic with serum (150 mmol). The formulations exemplified all contained 630 mg sodium bicarbonate.
US Patent Application No. 20040170681 describes a paracetamol formulation containing less than 100 mg sodium bicarbonate per tablet. About 90% of the paracetamol is described as being released from this formulation in 15 minutes using United States Pharmacopoeia (USP) dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. A formulation was exemplified which resulted in an area under the plasma concentration-time curve at 20 minutes after administration (AUC20) of 17 μg�min�mL−1 in fed subjects when given as a 1000 mg paracetamol dose.
United Kingdom Patent No. 2103087 describes the use of antacids in paracetamol tablets. Antacids including calcium carbonate and sodium bicarbonate were used in the range of 60-1200 mg. The greatest increase was noted with 225 mg of sodium bicarbonate which showed an increase in the rate of absorption of paracetamol of between 7% and 31% compared with conventional paracetamol tablets. The shortest Tmax reported was 29 minutes.
In accordance with the present invention, paracetamol formulations and in particular swallow formulations are defined in which the parameters for drug dissolution and absorption have been significantly improved.
SUMMARY OF THE INVENTION The present invention relates generally to paracetamol formulations in the form of fast absorbing oral delivery systems. In particular, the present invention provides a swallow formulation comprising paracetamol, one or more pH modulating agents, and one or more agents which facilitate water uptake. The paracetamol is incorporated as a rapidly dissolving form of paracetamol.
The present invention provides, therefore, a swallow formulation comprising a rapidly dissolving form of paracetamol, a pH modulating agent and an agent which facilitates water uptake, wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol acid and wherein at least about 70% of the paracetamol in the swallow formulation is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
The present invention further provides, a swallow formulation comprising a rapidly dissolving form of paracetamol, a pH modulating agent and an agent which facilitates water uptake, wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol acid and wherein at least about 5% of the paracetamol in the swallow formulation is dissolved from the swallow formulation within 300 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 0 rpm and 37� C.
The present invention also provides a swallow formulation comprising paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1, a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake into the formulation;
when the dissolution is measured in United States Pharmacopoeia (USP) dissolution apparatus 2 with 900 mL 0.0033 N hydrochloric acid at 37� C.
Preferably at least about 20% or more preferably at least about 40% of the paracetamol is dissolved form the swallow formulation within 300 seconds.
A rapidly dissolving form of paracetamol includes paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1. It also includes any paracetamol preparation which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds.
Accordingly, another aspect of the present invention is directed to a swallow formulation comprising a form of paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol acid; and an agent which facilitates water uptake; wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
In another embodiment, the present invention contemplates a swallow formulation comprising a form of paracetamol which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of 0.1 N hydrochloric acid; and an agent which facilitates water uptake; wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
The swallow formulation of the present invention achieves on administration of 1000 mg paracetamol, a mean AUC20 (i.e. area under the plasma concentration-time curve at 20 minutes after administration) of more than 150 min�mg�L−1 in fasted healthy human subjects.
Accordingly, another aspect of the present invention provides a swallow formulation comprising a form of paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake; wherein an administration of 1000 mg paracetamol achieves a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
In a related aspect, the present invention provides a swallow formulation comprising a form of paracetamol which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol acid; and an agent which facilitates water uptake; wherein an administration of 1000 mg paracetamol achieves a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
Another aspect of the invention provides a dosage form such as a coated tablet, uncoated tablet, capsule, powder, paste, cachet, colloid, gel or melt.
The present invention further contemplates a method for treating therapeutic indications including an analgesic or antipyretic effect in a human subject said method comprising administering to said subject a pain relieving effective amount of a swallow formulation comprising a rapidly dissolving form of paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1 with a pH modulating agent and an agent which facilitates water uptake into to the swallow formulation, wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid and wherein at least about 70% of the paracetamol in the swallow formulation is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
The present invention is further directed to the use of a form of paracetamol which achieves on administration of 1000 mg paracetamol, a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects in the manufacture of a medicament for the inducement of pain relief in a human subject.
In another embodiment, the present invention contemplates a method for treating pain or fever in a human subject said method comprising administering to said subject a pain relieving or fever reducing effective amount of a swallow formulation comprising a rapidly dissolving form of paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1 with a pH modulating agent and an agent which facilitates water uptake into to the swallow formulation, wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid and wherein an administration of 1000 mg paracetamol achieves a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
In still another embodiment, the present invention provides a method for inducing pain relief including an analgesic effect in a human subject said method comprising administering to said subject a pain relieving effective amount of a swallow formulation comprising a rapidly dissolving form of paracetamol which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds with a pH modulating agent and an agent which facilitates water uptake into to the tablet, wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid and wherein at least about 70% of the paracetamol in the swallow formulation is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Throughout this specification, unless the context requires otherwise, the word �comprise�, or variations such as �comprises� or �comprising�, will be understood to imply the inclusion of a stated element or integer or group of elements or integers but not the exclusion of any other element or integer or group of elements or integers.
The present invention provides a paracetamol formulation and in particular a fast dissolving oral dosage form of paracetamol. The oral dosage form is generally referred to herein as a swallow formulation. The swallow formulation generally comprises paracetamol combined with a pH modulating agent and an agent which facilitates uptake of water. The oral dosage form of the present invention may optionally be administered with water or any other aqueous-based fluid.
It is to be understood that unless otherwise indicated, the subject invention is not limited to specific formulation components, manufacturing methods, dosage regimens, or the like, and as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.
It must be noted that, as used in the subject specification, the singular forms �a�, �an� and �the� include plural aspects unless the context clearly dictates otherwise. Thus, for example, reference to �an agent� includes a single agent, as well as two or more agents; reference to �a pH modulating agent� includes a single pH modulating agent, as well as two or more pH modulating agents, reference to �a water uptake agent� includes a single water uptake agent or two or more water uptake agents; and so forth.
The rapidly dissolving form of paracetamol includes a paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1. Alternatively, or in addition, it includes any paracetamol preparation which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds.
Accordingly, another aspect of the present invention provides a swallow formulation comprising a form of paracetamol having a volume median diameter (D50) of less than 350 μm and a surface area of greater than 0.07 m2�g−1; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake; wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
In a related aspect, the present invention is directed to a swallow formulation comprising a form of paracetamol which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm at 37� C. of at least 30% in 180 seconds; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol acid; and an agent which facilitates water uptake, wherein at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. The swallow formulation of the present invention achieves on administration of 1000 mg paracetamol a mean AUC 20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
In a related aspect, the present invention provides a swallow formulation comprising a form of paracetamol which exhibits a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N hydrochloric acid at 30 rpm and 37� C. of at least 30% in 180 seconds; a pH modulating agent in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid; and an agent which facilitates water uptake wherein an administration of 1000 mg paracetamol results in a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
The terms �active agent�, �compound�, �pharmacologically active agent�, �medicament�, �active�, �active ingredient�, �drug� and �drug component� are used interchangeably throughout this specification. The terms also encompass pharmaceutically acceptable and pharmacologically active ingredients of those active agents specifically mentioned herein including but not limited to salts, esters, amides, pro-drugs, active metabolites, analogs and the like. When the terms �active agent�, �compound�, �pharmacologically active agent�, �medicament�, �active�, �drug�, �drug component� and �paracetamol� are used, then it is to be understood that this includes those compounds per se as well as pharmaceutically acceptable, pharmacologically active salts, esters, amides, pro-drugs, metabolites, analogs, etc. The terms �agent�, �compound� etc may be a single molecule or a composite of molecules.
By the term �effective amount� or �therapeutically effective amount� of paracetamol as used herein means that a sufficient amount of paracetamol is used to provide the desired therapeutic effect or the desired pharmacological, physiological or biochemical event including the amelioration of symptoms being treated or prevented. Of course, undesirable effects, e.g. side effects, are sometimes manifested along with the desired therapeutic effect; hence, a practitioner balances the potential benefits against the potential risks in determining what is an appropriate �effective amount�.
The terms �delivery� and �administration� are used interchangeably throughout the specification to mean the act of providing the oral dosage form to an individual. The term �administering� is considered herein synonymous with �delivering�, �providing�, �introducing� or �swallowing�.
By �pharmaceutically acceptable excipient� is meant a pharmaceutical vehicle comprised of a material that is not biologically or otherwise undesirable, i.e. the oral dosage form may be administered to a subject along with paracetamol without causing any or a substantial adverse reaction. Excipients may include carriers and other additives such as diluents, binders, detergents, coloring agents, flavoring agents, wetting or emulsifying agents, preservatives, glidants, lubricants and the like as well as disintegrants.
Similarly, a �pharmacologically acceptable� salt, ester, amide, pro-drug or derivative of paracetamol as provided herein is a salt, ester, amide, pro-drug or derivative that is not biologically or otherwise undesirable.
The terms �treating� and �treatment� as used herein refer to reduction or amelioration in severity and/or frequency of symptoms, elimination of symptoms and/or underlying cause and/or prevention of the occurrence of symptoms and/or their underlying cause. Thus, for example, �treating� a subject involves prevention of a particular disorder or adverse physiological event in a susceptible individual as well as treatment of a clinically symptomatic individual by inhibiting or causing regression of a particular condition. Thus, for example, a method of treating a subject in need of pain relief encompasses both prevention of pain as well as treating conditions of pain. Reference to the treatment of pain includes the induction of analgesia. In addition, the subject formulation is useful for treating the symptoms of conditions requiring pain relief. Conditions contemplated herein include conditions requiring pain and fever management including pain and/or fever relief, pain and/or fever prevention, pain and/or fever reduction and/or treatment of levels of pain and/or fever.
Cmax is the peak paracetamol plasma concentration. AUC20 is the partial area under the plasma concentration-time curve for 20 minutes after administration. Tmax is the time to reach peak paracetamol plasma concentration.
Reference to �a pH modulating agent� includes one or more than one pH modulating agents. These may include acids, bases or a combination of one or more acids and/or bases. Reference to more than one includes from 2 to about 10 such as 2, 3, 4, 5, 6, 7, 8, 9 or 10 pH modulating agents.
In one particular embodiment, at least one of the pH modulating agents is soluble and/or dispersible.
In another particular embodiment, at least one of the pH modulating agents is a base.
Non-limiting examples of suitable pH modulating agents include sodium carbonate, ammonium carbonate, sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate, disodium glycine carbonate, sodium glycine carbonate, lysine carbonate, arginine carbonate, citric acid, tartaric acid, malic acid, fumaric acid, metatartaric acid, adipic acid, sodium acid citrate, ascorbic acid and amino acids such as aspartic acid, glutamic acid, glycine, leucine, tyrosine and tryptophan as well as combinations of two or more of the above.
Suitably, at least one of the pH modulating agents is a carbonate such as an alkaline metal carbonate.
Desirably, the carbonate is water soluble.
Preferably the pH modulating agent in the swallow formulation is capable of neutralizing between 12 and 95 mL of 0.1 N HCl. In addition, the pH modulating agent of the swallow formulation is capable of neutralizing between 1.2 and 9.5 mmol of acid.
The pH modulating agent is generally present in an amount form about 2% to about 90% by weight of swallow formulation. More preferably the pH modulating agent is present in an amount from about 2% to about 80%, and most preferably from about 2% to about 70% by weight of swallow formulation. Examples of percentage amounts by weight of pH modulating agent include 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89 or 90%.
Preferably, the ratio of paracetamol to pH modulating agent is between 0.5:1 and 30:1 inclusive by weight. More preferably, the ratio of paracetamol to pH modulating agent is between 1:1 and 20:1 by weight. Examples including 0.5:1, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1, 15:1, 16:1, 17:1, 18:1, 19:1 20:1, 21:1, 22:1, 23:1, 24:1, 25:1, 26:1, 27:1, 28:1, 29:1 or 30:1 by weight.
In one embodiment, the pH modulating agent is sodium bicarbonate and/or potassium bicarbonate and/or magnesium carbonate and/or citric acid and is present in an amount from about 2% to 75% by weight of the swallow formulation.
Paracetamol is conveniently present in an amount of from about 1000 mg or approximately 500 mg per formulation (e. e.g. tablet) and the pH modulating agent is present in an amount from 50 mg to 450 mg per 500 mg of paracetamol such as 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449 or 450 mg per 500 mg formulation.
Preferably, the pH modulating agent is present in an amount from 100 to 300 mg per 500 mg paracetamol in the swallow formulation. Even more preferably the pH modulating agent is sodium bicarbonate.
More preferably the administration of 1000 mg paracetamol in the swallow formulation with water to fasted healthy human subjects provides a mean AUC20 of more than about 170 min�mg�L−1 in healthy fasted human subjects.
In one embodiment, the swallow formulation is a tablet and at least 70% of the paracetamol is dissolved from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. Even more preferably, at least 80% is dissolved in 180 seconds.
In another embodiment, the swallow formulation is a tablet and at least 70% of the paracetamol is dissolved from the swallow formulation within 120 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. Even more preferably, at least 80% is dissolved in 120 seconds.
In yet another embodiment, the swallow formulation is a tablet and at least 70% of the paracetamol is dissolved from the swallow formulation within 90 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. Even more preferably, at least 80% is dissolved in 90 seconds.
Reference to �paracetamol incorporated in the swallow formulation as a rapidly dissolving form of paracetamol� includes rapidly dissolving forms of paracetamol and any paracetamol which is converted to a rapidly dissolving form of paracetamol during the manufacturing process.
Rapidly dissolving form of paracetamol includes paracetamol having a surface area to mass ratio greater than about 0.08 m2�g−1 as measured by gas adsorption and/or paracetamol having a volume median diameter (D50) particle size less than about 300 μm as measured by laser diffraction.
In one embodiment, the paracetamol is in a rapidly dissolving form wherein desirably the dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N HCL with the paddle spinning at 30 rpm at 37� C. is at least about 30% in 180 seconds.
Alternatively a standard form of paracetamol may be converted to a rapidly dissolving form during the manufacturing process wherein the finished product will meet a dissolution rate in USP dissolution apparatus 2 using 900 mL of 0.05 N HCL at 30 rpm and 37� C. of at least about 70% in 180 seconds.
In one preferred embodiment, the amount of paracetamol dissolved from the swallow formulation in the presence of a carbonate pH modulating agent is at least 5 times greater than the amount of paracetamol dissolved from a swallow formulation without a carbonate pH modulating agent after 30 seconds in a USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
In one embodiment, the rapidly dissolving paracetamol has a D50 particle size less than 300 μm.
Rapidly dissolving forms of paracetamol include micro- or sub-micron particles and modified crystals of paracetamol as well as particles having a reduced particle size and/or increased surface area.
In a further embodiment, the rapidly dissolving form of paracetamol is a salt, ester, amide, pro-drug or other pharmaceutically acceptable derivative of paracetamol.
In one embodiment, paracetamol crystals are re-crystallised in the presence of a crystallization modifier such as a polymer or protein or mixtures thereof to produce modified crystals. Polymers which may be used include polyvinlypyrrolidone (PVP) and copolymers with polyvinlypyrrolidone subunits. Proteins which may be used include albumin (bovine or ovine), papain, pepsin and others. Preferably, polyvinlypyrrolidone is present during crystallization.
Preferably the PVP-paracetamol co-crystal has a surface area to mass ratio of greater than 0.2 m2�g−1 as measured by gas adsorption.
Conveniently, the modified paracetamol crystals have a D50 particle size in the range of 50-300 μm such as 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299 or 300 μm.
In one embodiment, the rapidly dissolving form of paracetamol is in the form of granules manufactured by granulation techniques including wet massing, dry slugging or compaction, fluidized bed or spray drying and may include the use of high energy granulators. The granules may also contain a pH modulating agent and/or a water uptake agent. The swallow formulation may optionally contain extra granular paracetamol and/or a pH modulating agent and/or water uptake agent.
Preferably, the granules include one or more disintegrants, such as but not limited to crospovidone, croscarmellose, sodium starch glycolate, starch and/or starch derivatives.
In one embodiment, the rapidly dissolving form of paracetamol is provided in a formulation comprising further molecules which enhance the dissolution of the paracetamol, such as eutectics including mannitol.
Accordingly, another embodiment of the present invention is directed to a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein and a pH modulating agent wherein the pH modulating agent is in an amount sufficient to neutralize from 0.6 mL to 110 mL 0.1 N hydrochloric acid and which permits at least about 70% of the paracetamol to dissolve from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. and which achieves on administration of swallow formulation totalling 1000 mg paracetamol a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
The skilled addressee will appreciate, the swallow formulation may also comprise one or more pharmaceutically acceptable excipients.
Reference to �a water uptake agent� includes any agent which will facilitate the uptake of water. These may include wicking agents, disintegrants, binders, carriers and other hydrophilic excipients that will absorb, dissolve in or wick water, used alone or in combination. Generally, but not exclusively, a �water uptake agent� facilitates uptake of water into the swallow formulation.
Suitable water uptake agents include cross-linked polyvinylpyrrolidone (crospovidone), croscarmellose sodium, sodium starch glycolate, starch, starch derivatives, low substituted hydroxypropylcellulose, alginic acid, sodium alginate, calcium sulfate, calcium carboxymethylcellulose, microcrystalline cellulose, powdered cellulose, colloidal silicon dioxide, docusate sodium, guar gum, hydroxypropyl cellulose, magnesium aluminium silicate, methylcellulose, polacrilin potassium, silicified microcrystalline cellulose, magnesium oxide, tragacanth, mannitol, sorbitol, xylitol, sucrose, lactose, fructose, maltose, polyethylene glycol, aminoacids, cyclodextrin, urea and/or polyvinylpyrrolidone (povidone, PVP).
The water uptake agent may be present in an amount from 2% to 80% by weight of the swallow formulation and more preferably between 2% and 60% by weight of the swallow formulation.
Preferably, the ratio of water uptake agent to pH modulating agent is between 0.1:1 and 20:1 by weight such as 0.1:1, 0.2:1, 0.3:1, 0.4:1, 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.8:1, 0.9:1, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1 or 15:1, 16:1, 17:1, 18:1; 19:1 and 20:1. More preferably the ratio of water uptake agent to pH modulating agent is between 0.3:1 and 15:1 by weight.
Optionally, the swallow formulation may also comprise one or more pharmaceutically acceptable excipients or other components such as flavoring agents, coloring agents, sweeteners and preservatives.
Accordingly, another aspect of the present invention is directed to a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein, one or more pH modulating agents wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and a water uptake agent in an amount up to 80% by weight of the swallow formulation which permits at least about 70% of the paracetamol to dissolve from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. and which achieves on administration of a swallow formulation totalling 1000 mg paracetamol a mean AUC20 of more than 150 min�mg�L−1 in fasted healthy human subjects.
In one embodiment, the swallow formulation is co-administered with an aqueous fluid such as water. The co-administered fluid may be administered, before, after or with the swallow formulation.
Accordingly, another aspect of the present invention is directed to a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein, a water uptake agent and one or more pH modulating agents wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid which permits at least about 70% of the paracetamol to dissolve from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. said dosage form further comprising one or more pharmaceutically acceptable carriers, diluents and/or excipients, wherein the swallow formulation is co-administered with fluid.
The paracetamol or salt or pro-active form may be provided from about 100 mg to about 1000 mg per swallow formulation such as 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545, 546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557, 558, 559, 560, 561, 562, 563, 564, 565, 566, 567, 568, 569, 570, 571, 572, 573, 574, 575, 576, 577, 578, 579, 580, 581, 582, 583, 584, 585, 586, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666, 667, 668, 669, 670, 671, 672, 673, 674, 675, 676, 677, 678, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689, 690, 691, 692, 693, 694, 695, 696, 697, 698, 699, 700, 701, 702, 703, 704, 705, 706, 707, 708, 709, 710, 711, 712, 713, 714, 715, 716, 717, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 728, 729, 730, 731, 732, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742, 743, 744, 745, 746, 747, 748, 749, 750, 751, 752, 753, 754, 755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766, 767, 768, 769, 770, 771, 772, 773, 774, 775, 776, 777, 778, 779, 780, 781, 782, 783, 784, 785, 786, 787, 788, 789, 790, 791, 792, 793, 794, 795, 796, 797, 798, 799, 800, 801, 802, 803, 804, 805, 806, 807, 808, 809, 810, 811, 812, 813, 814, 815, 816, 817, 818, 819, 820, 821, 822, 823, 824, 825, 826, 827, 828, 829, 830, 831, 832, 833, 834, 835, 836, 837, 838, 839, 840, 841, 842, 843, 844, 845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855, 856, 857, 858, 859, 860, 861, 862, 863, 864, 865, 866, 867, 868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878, 879, 880, 881, 882, 883, 884, 885, 886, 887, 888, 889, 890, 891, 892, 893, 894, 895, 896, 897, 898, 899, 900, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910, 911, 912, 913, 914, 915, 916, 917, 918, 919, 920, 921, 922, 923, 924, 925, 926, 927, 928, 929, 930, 931, 932, 933, 934, 935, 936, 937, 938, 939, 940, 941, 942, 943, 944, 945, 946, 947, 948, 949, 950, 951, 952, 953, 954, 955, 956, 957, 958, 959, 960, 961, 962, 963, 964, 965, 966, 967, 968, 969, 970, 971, 972, 973, 974, 975, 976, 977, 978, 979, 980, 981, 982, 983, 984, 985, 986, 987, 988, 989, 990, 991, 992, 993, 994, 995, 996, 997, 998, 999 or 1000 mg or a fraction in between. A range of from about 400 to 750 mg is particularly preferred such as from about 450 mg to about 700 mg such as 500 mg or 650 mg per swallow formulation.
The skilled addressee will appreciate the preferred amount of paracetamol will depend upon the intended user of the swallow formulation. For example, in infants under two months of age with post immunization fever 10 to 15 mg paracetamol per kilogram is the recommended dosage. For an adult dose of 1000 mg paracetamol the dose may be administered as a single dose administration comprising one, two, three, four or more swallow formulations. For example, a 1000 mg dose of paracetamol may be administered as a single dose administration of two swallow formulations each containing 500 mg paracetamol, a water uptake agent and pH modulating agent in an amount sufficient to neutralize from about 0.3 mL to about 55 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.03 mmol to about 5.5 mmol of acid.
In one embodiment, the swallow formulation is intended for use by an infant and paracetamol may be in the range of 100 to 250 mg.
In another embodiment, the swallow formulation is intended for use by an adult and paracetamol may be in the range of 250 to 1000 mg.
As indicated above, the most preferred pH modulating agent is sodium bicarbonate and/or calcium carbonate and/or magnesium carbonate and/or potassium bicarbonate which in the swallow formulation is present in from about 25 mg to 450 mg per swallow formulation such as 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 61, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449 or 450 mg.
The swallow formulation may also contain additional pharmaceutically active agents for example other analgesics such as codeine, hydrocodone, oxycodone, tramadol and propoxyphene, anti-inflammatory analgesics such as aspirin and ibuprofen, decongestants such as pseudoephedrine and phenylephrine, antitussives such as pholcodine and dextromethorphan, expectorants such as guaifenesin and bromhexine, non-sedating and sedating antihistamines such as diphenhydramine and chlorpheniramine and muscle relaxants such as doxylamine or salt of these drugs. Formulations may also contain a pharmaceutically acceptable adjuvant such as caffeine.
Accordingly, in one preferred embodiment, the present invention provides a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein, a water uptake agent and one or more pH modulating agents wherein the pH modulating agent in a dose of paracetamol is in an amount, sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid and one or more additional pharmaceutically active ingredients wherein 70% of the paracetamol dissolves from the swallow formulation within 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
Particularly preferred swallow formulations include swallow formulations comprising about 50-65% paracetamol, 21-26% pH modulating agent and about 12-18% water uptake agent by weight of swallow formulation and swallow formulations comprising 50-65% paracetamol, 21-26% sodium bicarbonate, 7-9% crospovidone and 5-7% starch derivative by weight of swallow formulation.
In another aspect of the present invention there is provided a dosage form comprising a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol, a water uptake agent and one or more pH modulating agents wherein the pH modulating agent in a dose of paracetamol is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid.
The dosage form may be a tablet, capsule, powder, cachet, paste, colloid, gel or melt. The dose form may optionally be in a chewable form.
The dosage form of the present invention may be coated, uncoated and/or layered tablet. Suitable coatings include water soluble polymer based coatings such as, povidone or hypromellose. Suitable coating polymers may also be a derivative of cellulose (cellulose acetophthalate, hypromellose phthalate) or a derivative of an acrylic polymer (methacrylate acid copolymer). Optionally, the dosage form may be coated with gelatin.
The dosage form may contain one or more further pharmaceutically active agents. In one embodiment, the dosage form is a multi phase release dosage form containing a further paracetamol having a dissolution of less than 30% in 180 seconds in USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
Swallow formulations of the present invention may be manufactured by admixing the ingredients simultaneously or sequentially and then converting into a dosage unit such as a tablet, capsule, wafer or the like.
Tablets of the present invention may be manufactured by direct compression or granulation and compression for example.
The present invention further contemplates a method for the amelioration of the symptoms of pain, fever or discomfort in a subject, said method comprising administering to said subject a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein, a water uptake agent and one or more pH modulating agents wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid, the administration being for a time and under conditions to prevent or ameliorate symptoms of the condition.
Another aspect of the present invention contemplates a method for effecting pain and/or fever management in a subject experiencing pain and/or fever or anticipating to experience pain and/or fever, said method comprising administering to said subject a swallow formulation comprising paracetamol incorporated as a rapidly dissolving form of paracetamol as described herein, a water uptake agent and one or more pH modulating agents wherein the pH modulating agent is in an amount sufficient to neutralize from about 0.6 mL to about 110 mL 0.1 N hydrochloric acid and/or to neutralize from about 0.06 mmol to about 11 mmol of acid, the administration being for a time and under conditions to prevent or ameliorate symptoms of the condition.
These methods may also involve the swallow formulation having one or more pharmaceutically acceptable excipients.
In the examples the following USP dissolution apparatus II with 1000 mL dissolution vessels and paddle stirrers was used to perform the dissolution testing:
VanKel VK 7010 Dissolution bath VanKel VK 750 D Heater/Circulator Gilson Minipuls peristaltic pump for automatic continuous sampling
Testing was conducted using 900 mL of two different dissolution media at 37� C. One was 0.05 N hydrochloric acid. The other was 0.0033 N hydrochloric acid which is effective in discriminating between fast dissolving formulations. 900 mL of this medium contains the absolute amount of acid estimated to be present in the gastric contents in vivo, namely 3 millimoles, and its pH will change when high levels of sodium bicarbonate used in some formulations are added.
The materials used for preparation of dissolution media were:
32% w/w concentrated hydrochloric acid (HCl) (AR quality from Rowe Scientific) RO water from in-house Millipore Elix� water system. Dissolution results were measured as the mean of 2 replicates. Repeating the testing at 0 rpm provides more discrimination between formulations.
For measurements at 30 rpm, after 20 minutes, the stirring speed was increased to demonstrate the extent of further dissolution that could be achieved.
For measurements at 0 rpm, after 60 minutes, the stirring speed was increased to demonstrate the extent of further dissolution that could be achieved.
In formulations containing paracetamol, paracetamol concentrations were measured using a Varian Cary 50 UV-Vis Spectrophotometer set at an appropriate wavelength. For each drug, the optimal wavelength was selected after running UV scans in the dissolution medium.
For formulations containing paracetamol and tramadol hydrochloride measured at 0 and 30 rpm, the concentrations of each drug were measured by HPLC analysis in 0.75 mL samples taken at 1, 2, 3, 5, 10, 15, 20 and 30 minutes. A final sample was taken at the end of the run after stirring at 250 rpm for 10 minutes to achieve the maximum dissolution Solution pH was measured using a TPS WP81 pH, Salinity, Temperature & Conductivity Meter.
Example 1 Selection of pH Modulating Agents Based on Pharmacokinetic Studies This non-limiting Example includes a range of different formulations based on rapidly dissolving paracetamol with carbonates as a pH modulating agent over the range 100-800 mg per dose as covered by this invention and the presence of water uptake agents that demonstrate improved tablet dissolution and AUC20 values. Formulation 1 covers the formulation and preparation of paracetamol-PVP crystals which were used as the rapidly dissolving paracetamol in many of the formulations.
All formulations were tested in fasted healthy human subjects, administering two tablets equivalent to a 1000 mg dose of paracetamol with water. Plasma levels of paracetamol were measured for up to 8 hours post-dosing, with at least 10 samples taken during the first hour. In vitro tablet dissolution was measured using USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C.
A linear in vitro-in vivo correlation (IVIVC) (R2=0.60) was established between paracetamol AUC20 and the fitted tablet dissolution exponential rate constant (kdiss) based on the evaluation of 23 different tablet formulations with each formulation evaluated in 5 subjects in a crossover design. Accordingly, an AUC20 of approximately 150 min�mg�L−1 corresponds to about 70% dissolution of paracetamol in 180 sec. A poorer linear correlation existed between Tmax and kdiss for the 23 formulations (R2=0.29). A low Tmax is generally associated with a high AUC20 but it was found that Tmax begins to plateau at an AUC20 of approximately 120 min�mg�L−1, supporting the use of AUC20 rather than Tmax as the preferred in vivo measure for rate of absorption.
A validation crossover study of two test and two commercially available formulations in 25 healthy fasted subjects gave a linear correlation between the mean AUC20 and in vitro dissolution rate constant, kdiss (R2=0.990). This regression suggests that an AUC20 of 150 min�mg�L−1 corresponds to about 70% of paracetamol dissolved from the formulations in 180 sec. The linear correlation between AUC20 and the % paracetamol dissolved at 180 seconds was R2=0.996.
The following tables provide examples of some of the formulations with in vivo pharmacokinetic data and in vitro dissolution performance.
TABLE 1 Formulation 1 For A Rapidly Dissolving Paracetamol No Ingredient mg/tablet 1 Povidone K-30 (PVP) 20-45 2 Water � 3 96% v/v ethanol � 4 Paracetamol 500 Procedure
A. Prepare a solution of approximately 1% w/w of 1 in 2 in a vessel and cool to 2-5� C. B. Heat 3 to around 70� C. , keeping the temperature below the boiling point of this flammable solvent, and add sufficient paracetamol to prepare a solution of approximately 35% w/w. C. Add B to A in the ratio approximately 1 to 3 by weight D. Stir for 5 seconds leaving the mixing vessel on ice. E. After 20 minutes, filter the resultant crystals under vacuum and dry at 40� C. to a moisture content of approximately 1%. F. Screen through an appropriate sieve (�840 μm). G. Assay for paracetamol content. The quantities of solvents, stirring procedures and settling time prior to filtration need to be determined for each batch size. Different ratios of ethanol and water can be used as solvents for the two phases.
Typically the crystals have a volume median diameter (D50) below 300 μm and perform as a rapidly dissolving form of paracetamol.
The resultant crystals typically contain 3-6% PVP, and are assayed for paracetamol content before use. This allows the quantity equivalent to 500 mg paracetamol to be calculated for further processing. The crystals are blended with other ingredients in any formulation before conversion to the finished product, such as by compression to produce a tablet or by filling the powder blend into capsules.
Formulations 2-10 are some of those that were tested in the multiple 5 subject crossover studies to demonstrate the effect of pH modulating agents on the in vitro dissolution and in vivo pharmacokinetic parameters. All are direct compression formulations prepared by blending the ingredients prior to compression.
Formulations 2-10 Containing Rapidly Dissolving Paracetamol
Rapidly Dissolving Paracetamol
pH modulating agent
Carbonates including 50-400 mg
sodium bicarbonate (100-800 mg per dose)
In Vitro Dissolution and In Vivo Data for Formulations 2-10
Mean AUC20 min � mg � L−1 (pooled data)
% released in
Mean AUC20
min �mg � L−1 Mean Tmax min
Formulations 11 and 12 are those containing rapidly dissolving paracetamol with pH modulating agent that were evaluated in vivo in 25 healthy fasted subjects compared with two commercially available brands of paracetamol described as �rapid release products�.
TABLE 4 Formulation 11 Prepared By Granulation No Ingredient mg/tablet Part 1 1 Povidone K-29/32 20 2 Water 3 Crospovidone 10 4 Paracetamol, micronised 500 Part 2 5 Sodium bicarbonate 200 6 Starch 1500 50 7 Crospovidone 60 8 Stearic acid 8 Part 1
A. Prepare a 13% w/w solution of 1 in 2. B. Blend 3 and 4. C. Spray A onto B in a granulator or mixer to produce a granule suitable for compression. D. Dry at 40� C. to a moisture content �1%. E. Screen through a 1,410 μm sieve.
F. Screen 5, 6 and 7 through a 250 μm sieve. G. Blend Part 1 with F. H. Screen 8 through a 250 μm sieve. I. Blend H with G. J. Compress. TABLE 5 Formulation 12 Prepared By Direct Compression Item number Ingredient mg/tablet 1 Crystals from Formulation 1 equivalent to 500 mg 519 Paracetamol 2 Sodium bicarbonate 200 3 Starch 1500 50 4 Crospovidone 60 5 Stearic acid 8 Procedure
A. Blend 1, 2, 3 and 4 B. Blend 5 with A C. Compress. TABLE 6
In Vitro And In Vivo Data For Formulations 11 and 12 Compared
With Two Commercially Available Paracetamol Products A and B
% dissolved in 90 seconds
in 900 mL 0.05 N
AUC20
min � mg � L−1 11
TABLE 5 Formulation 12 Prepared By Direct Compression Item number Ingredient mg/tablet 1 Crystals from Formulation 1 equivalent to 500 mg 519 Paracetamol 2 Sodium bicarbonate 200 3 Starch 1500 50 4 Crospovidone 60 5 Stearic acid 8 Procedure
Example 2 Selection of Rapidly Dissolving Paracetamol The following data demonstrate the effect of the addition of a pH modulating agent, sodium bicarbonate, on the in vitro dissolution of tablets made with different grades of paracetamol. Six different grades of paracetamol were tested in Formulations 13-18. For each sample of paracetamol, two formulations were prepared; one without pH modulating agent designated A, and one with pH modulating agent designated B.
TABLE 7 Formulations A and B Item mg/tablet number Ingredient Formulation A Formulation B 1 Paracetamol 100 100 2 Sodium bicarbonate 0 100 3 Microcrystalline cellulose 270 270 4 Crospovidone 25 25 5 Magnesium stearate 5 5 Procedure
A. Blend 1, 2, 3 and 4 B. Blend 5 with A C. Compress. In vitro dissolution was measured using USP dissolution apparatus 2 with 900 mL 0.05 N hydrochloric acid at 30 rpm and 37� C. The % paracetamol dissolved at 30 seconds was compared for each grade of paracetamol with and without the presence of a pH modulating agent, sodium bicarbonate. The % increase in dissolution caused by the sodium bicarbonate was calculated. It was found that the increase in dissolution caused by sodium bicarbonate is much higher for certain grades of paracetamol. For the purposes of this invention, where the increase is greater than 500%, these grades of paracetamol are described as rapidly dissolving paracetamol. Paracetamol used in Formulations 13-16 meet the definition of rapidly dissolving paracetamol and those used in Formulations 17-18 do not.
The Effect Of Paracetamol Grade On Dissolution Of Tablets
Formulated With And Without Sodium Bicarbonate
% paracetamol dissolved
after 30 sec
With 100 mg
with Sodium
(D50) μm
m2 � g−1 Bicarbonate A
Bicarbonate B
B/A � 100
Example 3 Selection of Range of Water Uptake Agents Based on In Vitro Dissolution Studies Various excipients used in the formulations can be generally classified as water uptake agents in addition to their specific categorization as disintegrants, wicking agents, binders and fillers. Microcrystalline cellulose is an example that can be described in all these categories. For the purposes of this invention, any excipients which are described in any of these categories are considered under the definition of water uptake agent.
It was found that in vitro dissolution did not occur rapidly unless there was sufficient water uptake agent present in combination with the pH modulating agent. It was further noted that a reduction in the in vitro dissolution of tablets was associated with an increase in the level of pH modulating agent, and that the dissolution performance could be restored by increasing the level of water uptake agent. Formulation 10 which contains water uptake agents but without any pH modulating agent shows slow dissolution of paracetamol reaching only 20% in 180 seconds. This compares with dissolution above 70% in 90 seconds when sufficient of both agents are present in the formulation.
The % of water uptake agents in the tablet and the ratio of the water uptake agents to the weight of pH modulating agents are important to achieve the target in vitro dissolution performance of the resultant tablet.
TABLE 9 Formulations With Dissolution Greater Than 70% In 180 Seconds Containing Different Water Uptake Agents mg/tablet Item Formulation Number No Ingredient 19 20 21 22 23 1 Paracetamol, micronised 500 500 500 100 100 2 Sodium bicarbonate 275 275 275 100 40 3 Microcrystalline cellulose 0 0 0 270 0 4 Povidone K-30 0 0 0 0 4 5 Starch 1500 70 70 70 0 10 6 Croscarmellose 0 67 0 0 0 7 Sodium starch glycolate 0 0 67 0 0 8 Crospovidone 67 0 0 0 12 9 Stearic acid 7 7 7 0 0 10 Magnesium stearate 0 0 0 5 1 Procedure
A. Blend items 1-8 according to the specific formulation B. Blend item 9 or 10 with A according to the specific formulation C. Compress. Examples 4 & 5 The present invention is further described by the following additional non-limiting examples which relate to products containing paracetamol which are prepared by wet granulation and demonstrate fast in vitro dissolution of the active ingredients under the test conditions described:
Example 4: Paracetamol 500 mg tablets Example 5: Paracetamol 325 mg with tramadol hydrochloride 37.5 mg Both examples contain dissolution profiles for:
one formulation according to the invention with bicarbonate alone designated 1 a second formulation according to the invention containing sodium bicarbonate with fumaric acid as an example of an organic acid designated 2 a commercial product which contains no pH modulating agents as well as any fast dissolving commercial products containing pH modulating agents For these examples, dissolution data are provided using different dissolution media and stirring conditions in USP dissolution apparatus 2 at 37� C. The additional methods using 0.0033 N hydrochloric acid at 30 rpm and 0 rpm discriminate better between formulations designed for fast dissolution than the 0.05 N hydrochloric acid where the effect of the high acid concentration tends to mask formulation effects on dissolution.
In 900 mL 0.0033 N hydrochloric acid, there is 3 millimoles of acid, approximating the amount of acid estimated to be present in the residual gastric contents in a fasted subject. This amount of acid can be completely neutralized by high amounts of bases used as pH modulating agents, so that the pH of the dissolution medium will change depending on the levels of pH modulating agents used in a formulation. This is particularly important for investigating the dissolution of drugs where their solubility is pH dependent. For example, tramadol hydrochloride is the salt of a base, and its solubility is reduced as the pH increases, whereas the solubility of paracetamol is independent of the pH.
Dissolution results using 900 mL 0.0033 N hydrochloric acid may be of importance in vivo as the acidity of gastric contents varies significantly, and low acid conditions are associated with the fed and partial prandial states, as well as in patients with suppressed gastric function. Further analysis of data from the trial on the rapidly absorbed paracetamol tablets in 25 healthy fasted human subjects carried out by the applicant, established an in vitro in vivo correlation (IVIVC) between the AUC10 (R2=0.91) and AUC20 (R2=0.87) for paracetamol and the in vitro % drug dissolved in 300 seconds in USP apparatus 2 with 900 mL 0.0033 N hydrochloric acid at 30 rpm and 37� C.
When the stirring speed is reduced to 0 rpm, the dissolution profiles demonstrate the intrinsic characteristics of the fast dissolving formulations of this invention which are able to enhance the dissolution of the drugs without any external stirring. Dissolution results without stirring may be of in vivo significance in conditions where there is gut stasis or reduced gastric activity.
For the dissolution profiles for paracetamol alone, drug concentrations were measured by UV absorbance at an appropriate wavelength for each drug using flow through cells for automatic continuous sampling.
For the paracetamol/tramadol dissolution profiles, drug concentrations were measured by HPLC analysis for each drug in samples taken at selected intervals.
Overview of Examples and Methods of Preparation
Example 4 covers paracetamol tablet formulations manufactured by a granulation process containing either sodium bicarbonate alone as the only pH modulating agent, or a combination of sodium bicarbonate and fumaric acid. These are compared with two commercial fast dissolving paracetamol products, Product X from the USA, and Product Y which contains 630 mg sodium bicarbonate as a pH modulating agent from Australia.
Example 5 covers tablet formulations manufactured by a granulation process containing paracetamol with the hydrochloride salt of a base analgesic drug, tramadol hydrochloride. One contains sodium bicarbonate alone as the pH modulating agent, and the other a combination of sodium bicarbonate and fumaric acid. These are compared with a commercial product sourced from the USA containing the same doses of paracetamol and tramadol hydrochloride.
Tables 10-12 summarise the percentages of the total dose of the drug dissolved for the two examples under different dissolution conditions, namely 900 mL 0.05 N hydrochloric acid at 30 rpm, 900 mL 0.0033 N hydrochloric acid at 30 rpm and 900 mL 0.0033 N hydrochloric acid at 0 rpm respectively. These include dissolution data for commercially available products.
Table 13 details the formulations for the two paracetamol formulations A1 and A2 of Example 4.
Tables 14-16 summarise the paracetamol dissolution data for the two formulations compared with the two commercial products, X and Y under the different dissolution conditions, namely 900 mL 0.05 N hydrochloric acid at 30 rpm, 900 mL 0.0033 N hydrochloric acid at 30 rpm and 900 mL 0.0033 N hydrochloric acid at 0 rpm.
Table 17 details the formulations for the two paracetamol with tramadol hydrochloride formulations, B1 and B2 of Example 5.
Table 18 summarises the dissolution data for paracetamol and tramadol hydrochloride from B1 and B2 compared with a commercial product, in 900 mL 0.05 N hydrochloric acid at 30 rpm.
Table 19 summarises the dissolution data for paracetamol and tramadol hydrochloride from B1 and B2 compared with a commercial product in 900 mL 0.0033 N hydrochloric acid at 30 rpm.
Table 20 summarises the dissolution data for paracetamol and tramadol hydrochloride from B1 and B2 in 900 mL 0.0033 N hydrochloric acid at 0 rpm.
FIGS. 1-3 illustrate the paracetamol dissolution profiles for the two formulations compared with Products X and Y under different dissolution conditions, namely 900 mL 0.05 N hydrochloric acid at 30 rpm, 900 mL 0.0033 N hydrochloric acid at 30 rpm and 900 mL 0.0033 N hydrochloric acid at 0 rpm respectively.
FIG. 4 illustrates the dissolution profiles for paracetamol and tramadol hydrochloride from B1 and B2 compared with a commercial product in 900 mL 0.05 N hydrochloric acid at 30 rpm,
FIG. 5 illustrates the dissolution profiles for paracetamol and tramadol ydrochloride from B1 and B2 compared with a commercial product in 900 mL 0.0033 N hydrochloric acid at 30 rpm.
FIG. 6 illustrates the dissolution profiles for paracetamol and tramadol hydrochloride from B1 and B2 in 900 mL 0.0033 N hydrochloric acid at 0 rpm.
CONCLUSIONS AND FURTHER COMMENTS BASED ON EXAMPLES 4 & 5 It will be apparent that the use of pH modulating agents in accordance with the current invention substantially increases the in vitro dissolution of the active ingredients from formulations containing paracetamol alone and in combination with other drugs such tramadol hydrochloride.
However, when paracetamol is used in combination with a base such as tramadol hydrochloride, it is found that the fastest in vitro dissolution of both drugs is achieved by using a bicarbonate with an organic acid compared with a bicarbonate alone. This combination of pH modulating agents provides intrinsic micro-stirring than will enhance the rate of dissolution of both drugs to a greater extent than the use of a base alone. Formulation B2 which contains an a pH modulating comprising an acid and a base at 19% w/w has a greater effect enhancing dissolution compared with B1 which contains 28% w/w of bicarbonate alone.
The in vitro dissolution results in 0.0033 N hydrochloric acid identify formulation differences that are not apparent when the more concentrated acid at 0.05 N hydrochloric acid is used. At 0 rpm, the effect of the intrinsic micro-stirring in the formulation is apparent.
Table 10 summarises dissolution data for formulation examples containing paracetamol alone (A), and paracetamol with tramadol hydrochloride (B) that demonstrate the current invention in 900 mL 0.05 N hydrochloric acid using USP apparatus 2 at 30 rpm and 37� C.:
Dissolution profiles for formulations according to the invention
at 30 rpm stirring speed in 900 mL 0.05 N hydrochloric acid
% dissolved in 900 mL 0.05 N
hydrochloric acid at 30 rpm
A1 (base alone)
A2 (base + acid)
Product Y (base)
B1 (base alone)
B2 (base + acid)
These results show that for a combination product of paracetamol with a salt of a basic drug, pH modulating agents comprising an acid and a base are required to achieve more than 70% dissolution of both drugs after 180 seconds at 30 rpm in 0.05 N hydrochloric acid. For paracetamol alone, a base alone is sufficient to achieve this rate of dissolution.
Table 11 summarises the dissolution data for formulation examples containing paracetamol alone (A), and paracetamol with tramadol hydrochloride (B) that demonstrate the current invention in 900 mL 0.0033 N hydrochloric acid using USP apparatus 2 at 30 rpm and 37� C.:
Dissolution profiles for paracetamol and tramadol hydrochloride
in formulations according to the invention at 30 rpm stirring
speed in 900 mL 0.0033 N hydrochloric acid
% dissolved in 900 mL 0.0033 N
These results in more dilute acid, show the enhanced dissolution of both paracetamol and tramadol hydrochloride from combination products when the pH modulating agent comprises a base and an acid. Only when the pH modulating agent comprises an acid and a base does the dissolution achieve greater than 70% in 180 seconds in this less acidic dissolution medium.
Table 12 summarises the dissolution data for formulation examples containing paracetamol alone (A), and paracetamol with tramadol hydrochloride (B) that demonstrate the current invention in 900 mL 0.0033 N hydrochloric acid using USP apparatus 2 at 0 rpm and 37� C.:
Dissolution profiles in formulations according to the invention
at 0 rpm stirring speed in 900 mL 0.0033 N hydrochloric acid
hydrochloric acid at 0 rpm
It will be apparent that the use of pH modulating agents in accordance with the current invention substantially increases in vitro dissolution of the therapeutic agents exemplified under conditions without stirring (0 rpm) that highlight the role of micro-stirring in enhancing dissolution.
It is clear from these results that all formulations containing an acid and a base according to the invention had:
a dissolution rate greater than 70% at 180 seconds at 30 rpm in 900 mL 0.05 N hydrochloric acid a dissolution rate greater than 70% at 180 seconds at 30 rpm in 900 mL 0.0033 N hydrochloric acid where a dissolution rate greater than 5% at 30 minutes at 0 rpm in 900 mL 0.0033 N hydrochloric acid. Formulations that contain a base alone and do not demonstrate these rates of dissolution are considered sub-optimal and would be reformulated to optimise the pH modulating agent for maximum dissolution.
Example 4 Paracetamol TABLE 13 Paracetamol Formulations A1 A2 Item Formulation (base alone) (base + acid) 1 Paracetamol (mg) 500 500 2 Crospovidone (mg) 40 40 3 Sodium bicarbonate (mg) 200 200 4 Fumaric acid (mg) 0 34 5 Starch 1500 (mg) 50 50 6 Povidone (mg) 34.4 40 7 Water 200 0 8 Ethanol 0 125 9 Crospovidone (mg) 60 60 10 Stearic acid 9 9 Total tablet weight (mg) 893.4 933 pH modulating agent (%) 22.4 25.1 Hardness (Kp) 10 17 Disintegration Time in 0.05 N hydrochloric 24 28 acid (Sec) Method for Formulation A1
A. Prepare a solution of 6 in 7. B. Blend items 1, 2 and 5. C. Spray A onto B in a granulator or mixer to form a granule suitable for compression. D. Dry at 70� C. inlet temperature in a fluid bed dryer to a loss on drying of �1% after heating at 100� C. for 5 minutes. E. Screen through a 1000 μm sieve.
F. Screen items 3, 9 through a 280 μm sieve. G. Blend Part 1 with F. H. Screen item 10 through a 280 μm sieve. I. Blend G with H. J. Compress using 19 mm�9 mm oval shallow concave tooling with a break bar on one face to suitable hardness and disintegration time.
Method for Formulation A2
A. Blend items 1 to 5. B. Prepare solution of 6 in 8. C. Spray B onto A in a granulator or mixer to form a granule suitable for compression. D. Dry at 40� C. to a loss on drying of <1% after heating at 50� C. for 20 min. E. Screen through a 500 μm sieve.
F. Screen item 9 through a 280 μm sieve. G. Blend Part 1 with F. H. Screen item 10 through a 280 μm sieve. I. Blend G with H. J. Compress using 19 mm�9 mm oval shallow concave tooling with a break bar on one face to suitable hardness and disintegration time.
For 900 mL 0.05 N acid at 30 rpm, dissolution data are summarised in Table 14 and the dissolution profiles are presented in FIG. 1 TABLE 14
Paracetamol Dissolution in 900 mL
0.05 N hydrochloric acid at 30 rpm
% drug dissolved in 900 mL 0.05 N hydrochloric
acid at 30 rpm
(base alone)
(base + acid)
Both paracetamol formulations demonstrate similar fast dissolution profiles, superior to both commercial products. The commercial product containing the sodium bicarbonate demonstrates faster dissolution than the commercial product without a base since the bicarbonate reacts with the high concentration of acid in the dissolution medium, and the resultant effervescence enhances dissolution.
For 900 mL 0.0033 N hydrochloric acid at 30 rpm, dissolution data are summarised in Table 15 and the dissolution profiles are presented in FIG. 2.
Paracetamol Dissolution in 900 mL 0.0033
N hydrochloric acid at 30 rpm
% drug dissolved in 900 mL 0.0033 N hydrochloric
The faster dissolution of the formulation with base and acid becomes apparent compared with the use of base alone. Both formulations are faster than the two commercial products, but in this weaker acid, the dissolution profile for the commercial product containing sodium bicarbonate is similar to that for the commercial product without any pH modulating agents.
At this lower acid concentration, the effect of the formulations per se in enhancing dissolution are becoming apparent and the pH change seen with the high level of sodium bicarbonate in Product Y is evident, increasing the pH to 6.6. In the weaker acid, the dissolution of formulation A2 containing both base and acid is faster than for the formulation A1 with base alone. In the latter case, formulation A1 is dependent on external acid for the micro-stirring to enhance dissolution. When the higher concentration of acid is used at 0.05 N, the vigorous reaction with any basic components in the formulations appears to mask any formulation effects.
For 900 mL 0.0033 N hydrochloric acid at 0 rpm, dissolution data are summarised in Table 16 and the dissolution profiles are presented in FIG. 3.
N hydrochloric acid at 0 rpm
acid at 0 rpm
The intrinsic effect of the formulations in enhancing dissolution becomes apparent as the effect of the external acidity in the dissolution medium is reduced and external stirring is eliminated. Under these conditions, only formulation A2 containing the base and acid continues to demonstrate fast and significant levels of dissolution. However the dissolution from formulation Al is still faster over the first 20 minutes than the two commercial products, particularly product Y containing sodium bicarbonate.
Example 5 Paracetamol and Tramadol Hydrochloride TABLE 17 Paracetamol and Tramadol Hydrochloride Formulations B1 B2 Item Formulation (base alone) (base + acid) 1 Paracetamol (mg) 325 162.5 2 Sodium bicarbonate (mg) 200 100 3 Crospovidone (mg) 10 12.5 4 Povidone (mg) 0 8.4 5 Water (mg) 0 50 6 Paracetamol (mg) 0 162.5 7 Tramadol Hydrochloride (mg) 37.5 37.5 8 Fumaric acid (mg) 0 34 9 Microcrystalline cellulose (mg) 0 50 10 Crospovidone (mg) 0 12.5 11 Povidone (mg) 13.67 5 12 Water (mg) 55 33 13 Prosolve (mg) 50 0 14 Microcrystalline cellulose (mg) 0 50 15 Crospovidone (mg) 60 60 16 Magnesium stearate (mg) 0 7 17 Steric acid (mg) 8 0 Total tablet weight (mg) 704.17 701.9 pH modulating agent (%) 28.4 19.1 Hardness (Kp) 14 10 Disintegration Time in 0.05 N hydrochloric 16 20 acid (Sec) Method for Formulation B1
A. Prepare a solution of 11 in 12. B. Blend items 1, 3, and 7. C. Spray A onto B in a granulator or mixer to form a granule suitable for compression. D. Dry at 50� C. to achieve moisture content <1%.
E. Screen granules from D through a 1,000 μm sieve. F. Screen items 2, 13 and 15 through a 280 μm sieve. G. Blend E with F. H. Screen item 17 through a 280 μm sieve. I. Blend G with H. J. Compress using 19 mm�7 mm oval shallow concave tooling with a break bar on one face to suitable hardness and disintegration time.
Method for Formulation B2
A. Prepare a solution of 1 in 12. B. Blend items 6, 7, 8, 9 and 10. C. Spray A onto B in a granulator or mixer to form a granule suitable for compression. D. Dry at 70� C. inlet temperature in a fluid bed dryer to a loss on drying of �1% after heating at 50� C. for 20 minutes.
E. Prepare a solution of 4 in 5. F. Blend items 1, 2 and 3. G. Spray A onto B in a granulator or mixer to form a granule suitable for compression. H. Dry at 70� C. inlet temperature in a fluid bed dryer to a loss on drying of <1% after heating at 50� C. for 20 minutes.
I. Screen granules from steps D & H through a 500 μm sieve. J. Screen items 14 and 15 through a 280 μm sieve. K. Blend Part I with J. L. Screen item 16 through a 280 μm sieve. M. Blend K with L. N. Compress using 19 mm�7 mm oval shallow concave tooling with a break bar on one face to suitable hardness and disintegration time.
In 900 mL 0.05 N acid at 30 rpm, both formulations demonstrate fast dissolution profiles for both drugs, superior to the commercial product which demonstrates a gradual increase in dissolution. The formulation with base and acid (B2) reaches 100% within 5 minutes for both paracetamol and tramadol. However, while the formulation with base alone (B1), shows fast dissolution for tramadol, it shows slower dissolution for the paracetamol, even though the level of pH modulating agent is higher at 28%,
Tramadol hydrochloride is more soluble than paracetamol with a solubility in water around 30 mg/mL compared with 14 mg/mL for paracetamol. On a weight for weight basis, the tramadol hydrochloride needs around 1 mL for total dissolution compared to around 27 mL for the dose of paracetamol.
These results suggest a synergistic effect of the base and acid together, achieving improved dissolution at a lower level of pH modulating agent. The intrinsic micro-stirring in the tablet appears to be more effective in promoting the dissolution of the lesser soluble drug compared with the mixing achieved as a result of the reaction between the base and the acid in the dissolution medium.
Paracetamol and Tramadol Hydrochloride Dissolution
in 900 mL 0.05 N hydrochloric acid at 30 rpm
% drug dissolved in 900 mL 0.05 N hydrochloric acid at 30 rpm
In 900 mL 0.0033 N hydrochloric acid at 30 rpm, only the formulation with base and acid (B2) demonstrates very fast dissolution reaching 100% within 5 minutes.
The formulation with the higher level of bicarbonate alone (28%) shows slower dissolution for both drugs although again, the dissolution of the more soluble tramadol hydrochloride is faster than that of the paracetamol. Dissolution of this formulation does not show significantly improved dissolution compared with the commercial product.
in 900 mL 0.0033 N hydrochloric acid at 30 rpm
% drug dissolved in 900 mL 0.0033 N hydrochloric acid at 30 rpm
In 900 mL 0.0033 N hydrochloric acid at 0 rpm, the intrinsic dissolution enhancing features of the formulations become apparent as the effect of the external acidity is reduced and external stirring is eliminated. Under these conditions, formulation B2 containing the base and acid demonstrates fast and significant levels of dissolution compared with the formulation with base alone.
in 900 mL 0.0033 N hydrochloric acid at 0 rpm
BIBLIOGRAPHY Ameer et al., J. Pharm. Sci, 72:955-958, 1983
Chen et al, Clin. Pharmacokinet. 40(8):565-72, 2001
Grattan et al, Eur. J. Pharm. Biopharm. 49 (3):225-229, 2000
FDA Guidance for Industry, Bioavailability & Bioequivalence Studies for Orally Administered Drug Products�General Considerations, March 2003
Luthy, et al. Schweiz Med. Wochenschr 123 (Suppl 50)/II:406, 1993
McNeil Consumer & Speciality Pharmaceuticals, Submission to the FDA on acetaminophen for 19 Sep. 2002 Non-prescription Drugs Advisory Committee Meeting.
Nielsen et al. Eur. J. Clin. Pharmacol. 42(3): 261-264, 1992
Prescott, Medical Clinics oj 'North America, 58:907-916, 1974
Prescott, Am. J. Ther. 7(2): 143 -147 2000
Rumble et al, Clin. Pharmacokinet. 20 (2): 167-173, 1991
Rumack et al, Pediatrics 62 (Suppl): 898-903, 1978
US Patent Application No. 20040170681
US Patent Application No. 20040204475
U.S. Pat. No. 6,316,025
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3390049Dec 23, 1964Jun 25, 1968Smith Kline French LabPharmaceutical tablets coated with wax-free ammonia solubilized water soluble shellacUS3851032 *Apr 23, 1973Nov 26, 1974Sterling Drug IncProcess of preparing a solid fine crystalline paracetamol polymer complex compositionUS4309408Nov 9, 1979Jan 5, 1982Beecham Group LimitedEffervescent powdersUS4687662Jan 15, 1986Aug 18, 1987Warner-Lambert CompanyTherapeutic effervescent compositionUS4704269Jun 11, 1985Nov 3, 1987Hudson Pharmaceutical CorporationEffervescent antacid and analgesic compositionsUS4704405Aug 25, 1986Nov 3, 1987Merck & Co., Inc.Rapid acting combination of sodium sulindac and a baseUS4824664Jan 20, 1987Apr 25, 1989Laboratoires Smith Kline & FrenchEffervescent couples, histamine H.sub.2 -antagonist effervescent compositions containing them and their preparationUS4834966Jul 22, 1987May 30, 1989Zambon S.P.A.Pharmaceutical composition with analgesic activityUS4942039Sep 5, 1989Jul 17, 1990Miles Inc.Effervescent analgesic antacid composition having reduced sodium contentUS5019399Jul 7, 1989May 28, 1991Lejus Medical AktiebolagGranular product (IV)US5064656Aug 28, 1990Nov 12, 1991Dr. Gergely & Co.Uncoated pharmaceutical reaction tabletUS5075291Nov 22, 1989Dec 24, 1991Ici Americas Inc.Crystalline sugar alcohol containing uniformly dispersed particulate pharmaceutical compoundUS5102665Mar 7, 1991Apr 7, 1992Glaxo Group LimitedPharmaceutical compositionsUS5118528Oct 4, 1990Jun 2, 1992Centre National De La Recherche ScientifiqueProcess for the preparation of dispersible colloidal systems of a substance in the form of nanoparticlesUS5145684Jan 25, 1991Sep 8, 1992Sterling Drug Inc.Surface modified drug nanoparticlesUS5158779Nov 2, 1988Oct 27, 1992Gerhard GergelyParticles of hydrophobic or sparingly soluble substanceUS5178878Apr 16, 1992Jan 12, 1993Cima Labs, Inc.Effervescent dosage form with microparticlesUS5225197Apr 27, 1990Jul 6, 1993Beecham Group PlcPharmaceutical formulationUS5260304Sep 6, 1990Nov 9, 1993Gerhard GergelyPharmaceutical preparation binding with gastric acidUS5262171Nov 25, 1991Nov 16, 1993Isp Investments Inc.Pharmaceutical tablet with PVP having enhanced drug dissolution rateUS5273759Sep 17, 1992Dec 28, 1993Lipopharm Inc.Method and composition for treating the migraine complexUS5312626Jul 1, 1992May 17, 1994Gerhard GergelyLozenge or chewable tabletUS5348475Apr 22, 1993Sep 20, 1994Jeneric/Pentron Inc.Trimodal method of curing dental restorative compositionsUS5348745May 5, 1992Sep 20, 1994Miles Inc.Aqueous granulation solution and a method of tablet granulationUS5419898Dec 20, 1993May 30, 1995Senju Pharmacuetical Co., Ltd.Antiallergic composition for ophthalmic or nasal useUS5424075Jun 29, 1992Jun 13, 1995Miles Inc.Delivery system for enhanced onset and increased potencyUS5425950May 31, 1994Jun 20, 1995Glaxo Group LimitedControlled release pharmaceutical compositionsUS5527540Apr 15, 1994Jun 18, 1996Gerhard GergelyEffervescent system having an alkali-sensitive and/or metal-sensitive, pharmaceutical active substance, and process for its preparationUS5587179Jan 12, 1993Dec 24, 1996Gerhard GergekyPharmaceutical formulation in the form of an effervescent and/or disintegrating tablet or of instant granulate, and process for their preparationUS5593693Sep 7, 1994Jan 14, 1997Gerhard GergelyEffervescent mixture with alkali metal salts or lysinates of acidic, insoluble or slightly soluble active ingredientsUS5639475Feb 3, 1995Jun 17, 1997Eurand America, IncorporatedEffervescent microcapsulesUS5670170May 18, 1995Sep 23, 1997Beecham Group P.L.C.Pharamaceutical formulationUS5709886Feb 19, 1997Jan 20, 1998Eurand America, IncorporatedEffervescent microcapsulesUS5733578Nov 15, 1995Mar 31, 1998Edward Mendell Co., Inc.Directly compressible high load acetaminophen formulationsUS5750145Jul 28, 1995May 12, 1998Bristol-Myers Squibb CompanyStable gelatin coated aspirin tabletsUS5759575Sep 9, 1994Jun 2, 1998Gerhard GergelyEffervescent granules and process for their preparationUS5762951Jul 26, 1993Jun 9, 1998Bayer AktiengesellschaftEffervescent composition and tablet made there fromUS5792473Mar 22, 1996Aug 11, 1998Gerhard GergelyGranular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparationUS5807577Nov 22, 1995Sep 15, 1998Lab Pharmaceutical Research International Inc.Fast-melt tablet and method of making sameUS5807578Nov 19, 1996Sep 15, 1998Lab Pharmaceutical Research International Inc.Fast-melt tablet and method of making sameUS5814337Oct 24, 1994Sep 29, 1998Beecham Group PlcPharmaceutical formulationUS5840737Jul 15, 1996Nov 24, 1998The Curators Of The University Of MissouriOmeprazole solution and method for using sameUS5854226Nov 14, 1995Dec 29, 1998Farmarc Nederland BvPharmaceutical compositionUS5858410Nov 9, 1995Jan 12, 1999Medac Gesellschaft Fur Klinische SpezialpraparatePharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solutionUS5863559Mar 2, 1992Jan 26, 1999Glaxo Group LimitedOral dosage form for treating migraineUS5869095Jul 18, 1996Feb 9, 1999Gerhard GergelyChewable tablet with an effervescent actionUS5914129Jul 23, 1996Jun 22, 1999Mauskop; AlexanderAnalgesic composition for treatment of migraine headachesUS5922355Sep 29, 1997Jul 13, 1999Research Triangle PharmaceuticalsComposition and method of preparing microparticles of water-insoluble substancesUS5962022Nov 30, 1994Oct 5, 1999Smithkline Beecham PlcPharmaceutical formulation with effervescent coupleUS6020001Jul 24, 1998Feb 1, 2000Glaxo Group LimitedCompositions for treating migraineUS6051254Sep 16, 1998Apr 18, 2000Smithkline Beecham PlcPharmaceutical formulationUS6077536Aug 19, 1998Jun 20, 2000Beecham Group PlcPharmaceutical formulationUS6149938Jul 23, 1998Nov 21, 2000Elan Pharma International LimitedProcess for the preparation of a granulate suitable to the preparation of rapidly disintegrable mouth-soluble tablets and compositions obtained therebyUS6156506Apr 1, 1997Dec 5, 2000Canon Kabushiki KaishaMethod for detecting a target substance in a sample, utilizing pyrylium compoundUS6160020Jun 19, 1998Dec 12, 2000Mcneill-Ppc, Inc.Alkali metal and alkaline-earth metal salts of acetaminophenUS6165506Sep 4, 1998Dec 26, 2000Elan Pharma International Ltd.Solid dose form of nanoparticulate naproxenUS6171617Feb 19, 1997Jan 9, 2001Losan Pharma GmbhEffervescent ibuprofen preparation and process for the production thereofUS6197336May 26, 1999Mar 6, 2001Zambon Group S.P.A.Fast dissolving compositions having analgesic activityUS6210711Jan 15, 1998Apr 3, 2001Pierre Fabre MedicamentEffervescent microspheres and method for making themUS6214386Nov 22, 1996Apr 10, 2001Recordati, S.A.Prompt-release oral pharmaceutical compositions for extemporaneous suspensionsUS6217907May 13, 1999Apr 17, 2001Edward Mendell Co., Inc.Directly compressible high load acetaminophen formulationsUS6242002Mar 26, 1999Jun 5, 2001Arzneimittelwerk Dresden GmbhEffervescent formulationsUS6245353Mar 26, 1999Jun 12, 2001Asta Medica AgSolid, rapidly disintegrating cetirizine formulationsUS6258814Oct 13, 2000Jul 10, 2001Schering CorporationMethod of using cetirizine and pharmaceutical compositions containing the same for inducing sleepUS6274172Jun 28, 1996Aug 14, 2001Smithkline Beecham Laboratoires PharmaceutiquesTherapeutic effervescent compositionsUS6277409Feb 11, 2000Aug 21, 2001Mcneil-Ppc, Inc.Protective coating for tabletUS6284272Jul 23, 1998Sep 4, 2001Chiesi Farmaceutici S.P.A.Pharmaceutical compositions containing an effervescent acid-base coupleUS6309668Jan 24, 1995Oct 30, 2001Aventis Pharma LimitedAbuse resistant tabletsUS6316025Feb 27, 1998Nov 13, 2001Smithkline Beecham PlcSwallow tablet comprising paracetamolUS6348485Jun 8, 1999Feb 19, 2002Takeda Chemical Industries, Ltd.Method for treating or preventing sleep disordersUS6350470Apr 29, 1999Feb 26, 2002Cima Labs Inc.Effervescent drug delivery system for oral administrationUS6368627Jan 13, 2000Apr 9, 2002Glaxo Group LimitedCompositionsUS6383471Apr 6, 1999May 7, 2002Lipocine, Inc.Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agentsUS6391337Mar 2, 2001May 21, 2002Edward Mendell Co., Inc.Directly compressible high load acetaminophen formulationsUS6432450Sep 6, 2000Aug 13, 2002Gerhard GergelyEffervescent granules with delayed effervescent effectUS6479551Mar 3, 2000Nov 12, 2002Pozen Inc.Treatment of migraine headacheUS6488961Dec 21, 1999Dec 3, 2002Ethypharm, Inc.Effervescent granules and methods for their preparationUS6489346Jan 11, 2000Dec 3, 2002The Curators Of The University Of MissouriSubstituted benzimidazole dosage forms and method of using sameUS6509036Oct 29, 2001Jan 21, 2003Cima Labs Inc.Effervescent drug delivery system for oral administrationUS6514531Dec 1, 1999Feb 4, 2003Sanofi-SynthelaboControlled-release dosage forms comprising zolpidem or a salt thereofUS6589556May 17, 2001Jul 8, 2003Capricorn Pharma, Inc.Rapid-melt semi-solid compositions, methods of making same and methods of using sameUS6620433Jul 3, 2002Sep 16, 2003Laboratorios Belmac, S.A.Dispersible and soluble galenic paracetamol formulation, method for its preparation and its applicationsUS6638535Apr 13, 2001Oct 28, 2003Synthon BvModified release formulations containing a hypnotic agentUS6641838Oct 29, 2001Nov 4, 2003Cima Labs Inc.Effervescent drug delivery system for oral administrationUS6645988Jul 9, 2001Nov 11, 2003Curators Of The University Of MissouriSubstituted benzimidazole dosage forms and method of using sameUS6649186Apr 20, 2000Nov 18, 2003EthypharmEffervescent granules and methods for their preparationUS6667056Aug 20, 2001Dec 23, 2003Chiesi Farmaceutici S.P.A.Pharmaceutical compositions containing an effervescent acid-base coupleUS6699885Jan 19, 2002Mar 2, 2004The Curators Of The University Of MissouriSubstituted benzimidazole dosage forms and methods of using sameUS6750237Nov 28, 2000Jun 15, 2004Astrazeneca AbPharmaceutical formulations containing zolmitriptanUS6780882Sep 30, 2002Aug 24, 2004The Curators Of The University Of MissouriSubstituted benzimidazole dosage forms and method of using sameUS20010014340Jun 12, 1997Aug 16, 2001Motohiro OhtaIntrabuccally rapidly disintegrating tabletUS20020031547Dec 24, 1997Mar 14, 2002Yamanouchi Pharmaceutical Co., Ltd.Immediately disintegrable medicinal compositionUS20020034540Feb 19, 1997Mar 21, 2002Ian Ashley PriceDosage form of ibuprofenUS20020071864Dec 7, 2001Jun 13, 2002Yuhan CorporationRapidly disintegrable tablet for oral administrationUS20020076439Oct 29, 2001Jun 20, 2002Pather S. IndiranEffervescent drug delivery system for oral administrationUS20020110578Feb 20, 2002Aug 15, 2002Pather Sathasivan IndiranSublingual buccal effervescentUS20030003146Jul 9, 2002Jan 2, 2003Yamanouchi Pharmaceutical Co., Ltd.Rapidly disintegrable pharmaceutical compositionUS20030035833Dec 5, 2001Feb 20, 2003Xiaorong HeRapidly dispersing pharmaceutical compositionUS20030069213Sep 29, 1998Apr 10, 2003Noritaka IiOral preparationUS20030091626Jul 2, 2002May 15, 2003Toshifumi KatsutaOrally disintegrating solid preparations and processes for the production thereofUS20040170681 *Jun 3, 2002Sep 2, 2004Grattan Timothy JamesSwallow tablet comprising paracetamolUS20040247677 *Jun 30, 2003Dec 9, 2004Pascal OuryMultilayer orodispersible tabletUS20050136120 *Jan 27, 2005Jun 23, 2005Heinrich KugelmannIntravenous pharmaceutical form of administrationWO2003082247A2 *Mar 25, 2003Oct 9, 2003Anna DrabkinDrug microparticlesWO2004012708A1 *Jul 30, 2003Feb 12, 2004Gruenenthal GmbhIntravenous pharmaceutical form of administration* Cited by examinerNon-Patent CitationsReference1Amendment dated Aug. 12, 2010 in U.S. Appl. No. 11/597,341.2Babalola et al., "Correlation between in vitro and in vivo parameters of commercial paracetamol tablets," (2001), Afr. J. Med Sci, 30, pp. 275-280.3Barbara Ameer et al., Absolute and Relative Bioavailability of Oral Acetaminophen Preparations, 72(8) J. Pharm. Sci., 955-958 (1983).4Barry H. Rumack, et al., Acetaminophen Overdose: Incidence, Diagnosis, and Management in 416 Patents, 62 (Suppl) Pediatrics, 898-903 (1978).5Borin et al., "Single dose bioavailability of acetaminophen following oral administration," (1989), International Journal of Pharmaceutics, 54, pp. 199-209.6Dominguez et al., "Bioequivalence study of paracetamol tablets: In vitro-in vivo correlation," (2000), Drug Development and Industrial Pharmacy, 26(8), pp. 821-828.7Final Office Action dated Oct. 25, 2010 issued in U.S. Appl. No. 11/597,341.8Garekani et al. Drug Dev. Ind. Pharm. 2a(2): 173-179 (2003).9Goldberg et al, J.Pharm.Biophrm 49(3):225-229 (2000).10Hedges et al., "A comparison of the absorption of effervescent preparations of paracetamol and penicillin V (Phenoxymethylpenicillin) with solid dose forms of these drugs," (1974), J. Clin. Pharmacol., 14, pp. 363-368.11Hekimoglu et al., "Comparative bioavailability of three batches of four commercial acetaminophen tablets," (1991), European Journal of Drug Metabolism and Pharmacokinetics, pp. 228-232.12Hekimoglu et al., "Comparative bioavailability of three commercial acetaminophen tablets," (1987), International J. Clin. Pharmacol., 25(2), pp. 93-96.13http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000003/ viewed on Mar. 7, 2012, 2009.14Ishikawa et al., "Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH-M-06) and spherical sugar granules," Chem. Pharm. Bull. (2001), 49(2), pp. 230-232.15 *Ivanov et al., Direct cytotoxicity of non-steroidal anti-inflammatory drugs in acidic media: model study on human erythrocytes with DIDS-inhibited anion exchanger, 2002, Pharmazie, vol. 57 (12), p. 848, abstract only.16J.C. Nielsen et al. Analgesic Efficacy of Immediate and Sustained Release Paracetamol and Plasma Concentration of Paracetamol. Double Blind, Placebo-Controlled Evaluation Using Painful Laser Stimulation, 42 European Journal of Clinical Pharmacology, 261-264 (1992).17 *Kolloffel et al., Rectal administration of paracetamol a comparison of a solution and suppositories in adult volunteers, 1996, Pharmacy World and Science, vol. 18, No. 1, pp. 26-29.18L. Kalantzi, et al. "Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol)" Journal of Pharmaceutical Sciences vol. 95, Issue 1, pp. 4-14, 2006.19L.F. Prescott et al. Gastrointestinal Absorption of Drugs, 58(5) The Medical Clinics of North America, 907-916 (1974).20Laurie F. Prescott, Paracetamol: Past, Present, and Future, 7 American Journal of Therapeutics, 143-147 (2000).21M. Iwuagwu, A. Onyekwell, Tropical J. Pharm Res. 1(1):29-37 (2002).22 *Moolenaar et al., Biopharmaceutics of rectal adminstration of drugs in man, 1979, Pharmaceutish Weekblad Scientific Edition, vol. 1, pp. 689-694.23Non-Final Office Action dated May 12, 2010 issued in U.S. Appl. No. 11/597,341.24Office Action dated Mar. 15, 2012 issued in U.S. Appl. No. 12/085,645.25Office Action dated Mar. 21, 2012 issued in U.S. Appl. No. 11/597,341.26Office Action from related U.S. Appl. No. 11/597,341, mailed May 12, 2010.27 *Particle characterization in Excipients, drug products, and drug substances, accessed Oct. 7, 2009. http://www.geochem.sgs.com/Isnewsqc/Isnewsqc-july-issue/particle-characterisation-in-excipients-drug-products-and-drug-substances-Iss-newsletter.htm.28 *Particle characterization in Excipients, drug products, and drug substances, accessed Oct. 7, 2009. http://www.geochem.sgs.com/Isnewsqc/Isnewsqc�july�issue/particle�characterisation�in�excipients�drug�products�and�drug�substances�Iss�newsletter.htm.29Retaco et al., "Bioavailibility study of paracetamol tablets in saliva and urine," (1996), European Journal of Drug Metabolism and Pharmacokinetics, 4, pp. 295-300.30Roger H. Rumble et al., Effect of Posture and Sleep on Pharmacokinetics of Paracetamol (Acetaminophen) and Its Metabolites, 20(1) Clinical Pharmacokinetics, 167-173 (1991).31 *Rubinstein et al., The effect of Excipient Solubility on the in-vitro and in-vivo properties of bendrofluazide tablets 5mg, 1977, vol. 3, No. 5, pp. 439-450, Abstract Only.32Rygnestad et al., "Absorption of effervescent paracetamol tablets relative to ordinary paracetamol tablets in healthy volunteers," (2000), Eur J. Clin Pharmacol, 56, pp. 141-143.33Sevilla-Tirado et al., "Bioavailability of two new formulations of paracetamol compared with three marketed formulations, in healthy volunteers," (2003), Methods Find Exp Clin Pharmacol, 25(7), pp. 531-535.34Soininen et al., "Dissolution rate of different kinds of granulated micronized paracetamol with adjuvant incorporated either inter-or intragramularly," (1981), Acta Pharm. Fenn, 90, pp. 153-162.35Sotiropoulus et al., "Comparative bioavailability of three commercial acetaminophen tablets," (1981), Journal of Pharmaceutical Sciences, 70(4), pp. 422-425.36Tim Grattan et al., A Five Way Crossover Human Volunteer Study to Compare the Pharmacokinetics of Paracetamol Following Oral Administration of Two Commercially Available Paracetamol Tablets and Three Development Tablets Containing Paracetamol in Combination With Sodium Bicarbonate or Calcium Carbonate, European J. Pharmacetics and Biopharmaceutics, 225-299 (2000).37 *US Pharmacopeia, Particle Size Distribution Estimation by Analytical Sieving, accessed Oct. 7, 2009. http://www.pharmacopeia.cn/v29240/usp29nf24s0-c786.html.38 *US Pharmacopeia, Particle Size Distribution Estimation by Analytical Sieving, accessed Oct. 7, 2009. http://www.pharmacopeia.cn/v29240/usp29nf24s0�c786.html.39Walters, J. Pharm. Pharmacol. 20:228s-231s (1968).* Cited by examinerClassifications U.S. Classification424/489, 514/676, 514/675, 424/464International ClassificationA61K31/12, A01N35/00, A61K9/14, A61K9/16, A61K9/20, A61K31/167Cooperative ClassificationA61K9/146, A61K9/2027, A61K9/2077, A61K9/2009European ClassificationA61K9/20K2, A61K9/14H6, A61K9/20H6B, A61K9/20H2Legal EventsDateCodeEventDescriptionFeb 26, 2007ASAssignmentOwner name: IMAGINOT PTY LTD., AUSTRALIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ROBERTS, MICHAEL STEPHEN;JIANG, RUOYING;BEZANEHTAK, KEIVAN;AND OTHERS;REEL/FRAME:018973/0413;SIGNING DATES FROM 20070129 TO 20070206Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ROBERTS, MICHAEL STEPHEN;JIANG, RUOYING;BEZANEHTAK, KEIVAN;AND OTHERS;SIGNING DATES FROM 20070129 TO 20070206;REEL/FRAME:018973/0413RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google