Source: http://www.google.com/patents/US7005109?dq=7020618
Timestamp: 2016-05-02 09:03:49
Document Index: 769627514

Matched Legal Cases: ['arts 2', 'art 2', 'art 2', 'art 2', 'art 2', 'art 2', 'art 2', 'arts 2', 'art 2', 'art 2', 'art 2', 'art 2']

Patent US7005109 - System for handling liquid samples - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA system for handling liquid samples, comprising at least two superposed and interconnected planar elements between which a well for a liquid sample is formed which extends between an outwardly leading mouth to receive and/or deliver a liquid sample and an outwardly leading passage to connect the well...http://www.google.com/patents/US7005109?utm_source=gb-gplus-sharePatent US7005109 - System for handling liquid samplesAdvanced Patent SearchPublication numberUS7005109 B2Publication typeGrantApplication numberUS 10/046,522Publication dateFeb 28, 2006Filing dateJan 14, 2002Priority dateJul 15, 1999Fee statusPaidAlso published asDE19933458A1, DE19933458B4, DE50015274D1, EP1194240A1, EP1194240B1, US20020061260, WO2001005505A1Publication number046522, 10046522, US 7005109 B2, US 7005109B2, US-B2-7005109, US7005109 B2, US7005109B2InventorsDieter HusarOriginal AssigneeEppendorf AgExport CitationBiBTeX, EndNote, RefManPatent Citations (29), Non-Patent Citations (1), Referenced by (15), Classifications (13), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetSystem for handling liquid samples
US 7005109 B2Abstract
having at least two superposed and interconnected planar elements (2, 3) between which a well (4) for a liquid sample is formed which extends between an outwardly leading mouth (5) to receive and deliver a liquid sample and an outwardly leading passage (16) to connect the well (4) to a displacement device (21) for air or another gas; and
a handling apparatus having a displacement device (21), a device for releasably mounting the at least one device for handling the liquid samples (1), and a line (20) sealingly connecting the displacement device (21) to the passage (16) if the device for handling liquid samples (1) is disposed in the device for releasably mounting,
wherein the mouth (5) of the device for handling liquid samples (1) is disposed in a first peripheral area or in the vicinity thereof, and the passage (16) is disposed in the vicinity of a second peripheral area remote from the first peripheral area or in this second peripheral area,
wherein the at least one device for handling liquid samples (1) is substantially of a tongue shape with a tapered end and has the mouth (5) in a first end side and the passage (16) in a longitudinal side, and
wherein the at least one device for handling liquid samples (1) is tapered towards the mouth (5) in the main plane of extension of the planar elements (2, 3) and/or in a direction perpendicular thereto.
2. The system according to claim 1, wherein the planar elements (2, 3) and/or the limitation wall of the device for handling liquid samples (1) are laminas and/or sheetings and/or membranes.
3. The system according to claim 1, wherein the planar elements (2, 3) of the device for handling liquid samples (1) are made of plastic and/or glass and/or a semiconductor material and/or metal.
4. The system according to claim 1, wherein the well (4) of the device for handling liquid samples (1) comprises an indentation in one side of a planar element (2) which is covered by another planar element (3) and/or wherein the well (4) comprises indentations in the sides facing each other of two superposed planar elements (2, 3) and/or wherein the well (4) comprises a through opening in a planar element (2, 3) which is covered by planar elements (2, 3) on either side.
5. The system according to claim 4, wherein a planar element (2) of the device for handling liquid samples (1) covers a lamina having a well formed as an indentation on one side and another planar element (3) is a sheeting which covers the lamina on the side where the well (4) is.
6. The system according to claim 1, wherein the mouth (5) of the device for handling liquid samples (1) is extended outwardly in a first peripheral area of the interconnected planar elements (2, 3) between the interconnected planar elements (2, 3) or is extended outwardly in a cross direction through one of the interconnected planar elements (2, 3).
7. The system according to claim 1, wherein the passage (16) of the device for handling liquid samples (1) is extended outwardly in a cross direction through one of the interconnected planar elements (2, 3) or is extended outwardly in a second peripheral area of the interconnected planar elements (2, 3) between the interconnected planar elements (2, 3).
8. The system according to claim 6, wherein the mouth (5) of the device for handling liquid samples (1) is extended outwardly between a lamina and a sheeting and/or the passage (16) is extended outwardly in a cross direction through a sheeting covering a lamina.
9. The system according to claim 1, wherein the well (4) of the device for handling liquid samples (1) is a channel.
10. The system according to claim 1, wherein the mouth (5) of the device for handling liquid samples (1) is disposed at one end of the well (4) and the passage (16) is disposed at the other end of the well (4).
11. The system according to claim 9, wherein the channel substantially extends in the longitudinal direction of the device for handling liquid samples (1).
12. The system according to claim 9, wherein the channel of the device for handling liquid samples (1) is of a meander shape or a spiral shape.
13. The system according to claim 1, wherein the well (4) of the device for handling liquid samples (1), at its end opposed to the mouth (5), is connected to a secondary well (8), which is smaller than the well (4), via a channel having a cross-section which is smaller than that of the well (4).
14. The system according to claim 1, wherein the well (4) of the device for handling liquid samples (1) is tapered towards the mouth (5) in a nozzle-like manner and/or is expanded in a diffusor-like manner.
15. The system according to claims 1, wherein the mouth (5) of the device for handling liquid samples (1) comprises a plurality of mouth channels which are oriented in parallel or towards a common centre or are divergent.
16. The system according to claim 1, wherein the device for handling liquid samples (1), in the vicinity of the mouth (5), has at least one step (35) and/or at least one guide element in order to be supported and/or guided on a reference object.
17. The system according to claim 1, wherein the device for handling liquid samples (1), outside around the border of the passage (16), has a sealing surface to sealingly connect a displacement device (21) there.
18. The system according to of claim 1, wherein the well (4) of the device for handling liquid samples (1) has a plurality of reception chambers (4 IV) which are connected to each other by connection channels (33).
19. The system according to claim 1, wherein at least one planar element (2, 3) of the device for handling liquid samples (1) has a surface adjacent to the well (4) that is chemically modified and/or is structured.
20. The system according to claim 1, wherein the device for handling liquid samples (1) has at least one additional functional element which is a membrane (17) and/or a nonwoven fabric and/or a filtration element and/or an optical window and/or an electrode and/or a surface-enlarging and/or turbulence-promoting and/or shear force-producing structure and/or is a positioning element and/or a catch member and/or a code (14).
21. The system according to claim 20, wherein the membrane (17) and/or the nonwoven fabric and/or the filtration element of the device for handling liquid samples (1) is disposed between two planar elements (2, 3) between a well (4) and a passage (16) and/or at least two wells (4) and/or one well (4) and a mouth (5) of the various planar elements (2, 3).
22. The system according to claim 21, wherein a planar element (2) of the device for handling liquid samples (1) has at least one indentation (18) in which the membrane (17) and/or the nonwoven fabric and/or the filtration element are placed so that it/they forms/form a plane, which is completely covered by another planar element (3), with the adjacent area of the planar element (2).
23. The system according to claim 24, wherein the well (4V) for a sample liquid of the device for handling liquid samples (1), in a planar element, have associated therewith a well (36) for a dialytic liquid in a further planar element and the two wells (4V, 36) are separated by a dialytic membrane (36′) disposed between the planar elements.
24. The system according to claim 23, wherein the well (36) of the device for handling liquid samples (1) for a dialytic liquid has at least one aperture (37, 38) to pass a dialytic liquid therethrough.
25. The system according to claim 20, wherein the code (14) and/or the positioning element and/or the catch element, at an outside of the device for handling liquid samples (1), are disposed at a spacing from the mouth (5).
26. The system according to claim 1, wherein at least one planar element (2, 3) of the device for handling liquid samples (1) is permeable to radiation for an optical measurement.
27. The system according to claim 1, wherein the device for handling liquid samples (1) has at least one light beam-conducting element for an optical measurement.
28. The system according to claim 1, wherein the mouth (5) and/or the passage (16) and/or the aperture (37, 38) of the device for handling liquid samples (1) have associated therewith at least one closure which can be optionally closed.
29. A system having a plurality of juxtaposed and interconnected devices of the device for handling liquid samples (1) according to claim 1.
30. The system according to claim 29, wherein the plurality of juxtaposed and interconnected devices of the device for handling liquid samples (1) are formed from common planar elements (2, 3).
31. A system comprising a plurality of superposed devices for handling liquid samples (1) according to claim 1.
32. The system according to claim 31, wherein the superposed devices for handling liquid samples (1) are connected to each other.
33. The system according to claim 29, wherein the device for handling liquid samples (1) is adapted to be disassembled into at least two smaller devices for handling liquid samples (1) along at least one break line disposed between two wells.
34. The system according to claim 1, wherein the displacement device (21) or the actuation device and the device for mounting are fixedly connected to each other.
35. The system according to claim 1, wherein the displacement device (21) has at least one piston cylinder device (24, 25).
36. The system according to claim 1, wherein the displacement device (21) has a pump and a valve device to connect or disconnect the suction end in the pump to or from the device for handling liquid samples (1).
37. The system according to claim 36, which has a chamber for a positive and/or negative pressure which is connected to the pump and is adapted to be connected to the device for handling liquid samples via the valve device.
38. The system according to claim 1, wherein the displacement device (21) or the actuation device initiates one or more pressure fluctuations in the well (4) in a mixed mode of operation in order to thoroughly mix a liquid sample in the well (4).
39. The system according to claim 1, wherein the device for releasably mounting is a plug-in well into which a device for handling liquid samples (1) is adapted to be lockingly plugged in with a plug-in end.
40. The system according to of claim 1, wherein the device for releasably mounting has associated therewith a pressure spring (23) which presses a plugged-in device for handling liquid samples (1) against the line (20) or the actuation device.
41. The system according to claim 1, wherein the line (20) has associated therewith an O-type sealing ring (22) for sealingly bearing on the outer edge of the passage (16) of the device for handling liquid samples (1).
42. The system according to claim 1, wherein the device for releasably mounting helps in mounting at least two devices for handling liquid samples (1) in such a way that the wells (4) thereof are sealingly connected to each other via the passage (16) and/or the mouth (5) and the passage (16) or the limitation wall of one device for handling liquid samples (1) is connected to the displacement device (21) or is coupled to the actuation device in order to receive a sample liquid in a device for handling liquid samples (1) from outside and/or to deliver it to the outside and/or to transfer it between at least two devices for handling liquid samples.
43. The system for handling liquid samples according to claim 1, comprising a handling apparatus with a centrifuge rotor (27) which has a device for releasably mounting at least one device for handling liquid samples (1).
44. The system according to claim 43, wherein the device for releasably mounting is a well (28) for positively receiving a device for handling liquid samples (1).
45. The system according to claim 43, wherein the well has recessed grips (29) for laterally gripping the device for handling (1) and/or has locking elements for laterally locking the device for handling liquid samples (1) in place and/or has sealing elements for sealing the apertures of the device for handling (1).
46. The system according to claim 1, which has a device for releasably mounting at least two devices for handling liquid samples (1) which is such that the wells (4) thereof are sealingly connected to each other via the passage (16) and/or the mouth (5) in order to transfer sample liquid between the devices for handling liquid samples (1) during centrifuging.
47. A system for handling liquid samples according to claim 1, including a handling apparatus with a heating device and a support associated therewith for storing at least one device for handling liquid samples (1) so that a liquid sample received therefrom is adapted to be heated by means of the heating device.
48. The system according to claim 47, wherein the heating device has a contact surface which comes into a surface contact with a planar element (2,3) of the device for handling liquid samples (1) if a device for handling liquid samples (1) is stored on the support.
49. A system for handling liquid samples according to claim 1, including a handling apparatus with an optical measuring device and a device for releasably mounting at least one device for handling liquid samples (1) so that the latter, if arranged in the device for releasably mounting, is disposed with its well (4) in the path of beams of the optical measuring device.
50. The system according to claim 1, wherein the elements of one or more handling apparatuses are disposed in or on at least one chassis and/or casing.
51. The system according to claim 50, wherein a plurality of handling apparatuses have one or more common elements.
52. The system according to claim 1, wherein the at least one handling apparatus is manually operable and/or works automatically and/or is an apparatus that can be held by hand (a hand-operated apparatus).
53. The system according to claim 1, wherein at least two handling apparatuses interact automatically.
54. The system according to claim 1, wherein at least one further handling device exists for transporting devices for handling liquid samples (1) between various handling apparatuses and/or at least one handling apparatus and an input station and/or an output station and/or for supporting the handling apparatuses during their operation.
Proportioning of volumes between 0.2 and 5,000 microliters using pipette tips or syringes along with appropriate proportioning devices, Sample transport, centrifuging, tempering, and mixing using reaction vessels for volumes of from 0.2 to 2.0 ml along with appropriate devices, Measuring equipment based on cuvettes and fluorimeters, luminometers, and photometers, and Cell manipulation (e.g. cell fusion, cell poration, and cell positioning) which is particularly based on cuvettes. However, more and more smaller volumes and more and more higher spatial densifications of the volumes are used at an increasing tendency in all fields in the medical, biological or chemical laboratories. Since the end of the 80-ties, the microtitration plate which comprises a multiplicity of sample receptacles in the form of indentations lined up in rows next to each other has pushed its way instead of using individual reaction vessels, particularly in immunological analytics. As a result, the existing proportioning systems (e.g. the microliter pipette) were further improved to form multi-channel proportioning systems.
The fact that the handling devices are thin-walled ensures a very rapid heat transfer. This is advantageous for special applications, e.g. in the PCR (polymerase chain reaction). If the handling devices are employed there it is possible to achieve very rapid tempering cycles.
The fact that the wells are closed from the environment prevents any cross-contamination. This specifically applies to designs having filtration membranes and to the version having a displaceable limitation wall.
It is very easy to provide the handling devices with filtration elements (particularly filtration membranes) which can be easily mounted on the planar geometries, e.g. by lamination.
FIG. 1 shows a proportioning disposable in an exploded perspective view;
FIG. 2 shows the connection and fixation areas of a proportioning disposable with a membrane filter in an exploded perspective view;
FIGS. 3 a and b show a mouth portion of volume-receiving parts of the proportioning disposable of FIG. 1 (FIG. 3 a) and a proportioning disposable having a nozzle-like taper (FIG. 3 b) in a perspective side view;
FIG. 4 shows a proportioning disposable with a plurality of parallel juxtaposed proportioning disposables of FIG. 1 in an exploded perspective view;
FIG. 5 shows a planar element of another proportioning disposable in a perspective side view;
FIG. 6 shows a volume-receiving part of a proportioning disposable with a plurality of parallel juxtaposed volume-receiving parts of FIG. 5 in a perspective side view;
FIG. 7 shows a plurality of superposed proportioning disposables of FIG. 5 in a perspective side view;
FIG. 8 shows a plurality of superposed proportioning disposables of FIG. 6 in a roughly schematic perspective side view;
FIG. 9 shows a proportioning disposable connected to a line leading to a displacement device;
FIG. 10 shows a centrifuging disposable in a roughly schematic longitudinal view;
FIG. 11 shows several centrifuging disposables according to FIG. 9 in a centrifuge rotor;
FIG. 12 shows a centrifuge rotor having a well for a centrifuging disposable in a perspective side view;
FIG. 13 shows structural elements for a disposable in a perspective side view;
FIG. 14 shows the volume-receiving part of a reaction disposable in a perspective side view;
FIG. 15 shows the volume-receiving part of a gel disposable in a perspective plan view;
FIG. 16 FIG. 16 shows a dialytical disposable in an exploded perspective view;
FIG. 17 shows the volume-receiving part of a centrifuging/filtration disposable in a perspective plan view.
FIG. 18 shows a cuvette disposable in a perspective longitudinal section.
(Hot) embossing or injection moulding for planar plastic material (e.g. laminas or sheetings) Laser-beam or water-jet cutting in sheetings made of plastic (particularly for small series) Micromechanical machining (particularly for small series) Etching techniques (wet or dry) for glass and silicon. For instance, the modification of surfaces may be carried out by means of chemical surface treatments (e.g. polymer grafting, etching techniques, electroplating processes), by means of plasma processes (e.g. corona treatment) or plasma coating processes or by means of CVD (chemical vapour deposition) or PVD (physical vapour deposition).
e) Disposables for Bacteria Cultures/Microdialysis
FIG. 1 shows a version of an embodiment of a single proportioning disposable 1 which consists of two superposed planar elements 2, 3 having an elongate shape or tongue-like shape.
FIG. 2 shows a region of another proportioning disposable 1′ the single difference of which from the proportioning disposable 1 of FIG. 1 is that it has an additional planar element 17 in the form of a membrane sheeting which is disposed between the passage 16 and the secondary well 8. The membrane sheeting 17 can be a membrane as is used for sterile filtration where the pore sizes are 0.2 μm or 0.45 μm, for instance. The membrane sheeting 17 serves for filtering the suction air to avoid the contamination of the handling apparatus to be joined to the passage 16. The membrane sheeting 17 is intended to cover the passage area of the suction air so that it is sufficient for it to slightly project beyond the edge of the passage 16 or that of the secondary well 8. In the example, it is approximately of a square shape with its width corresponding to the width of the covering sheeting 3.
FIGS. 3 a and b show versions of the mouth area of proportioning disposables. Only the volume-receiving parts 2, 2′ are shown with no cover sheetings.
According to FIG. 3 a, the planar element 2 has a well 4 the depth of which decreases to 0.1 mm at the mouth in the nozzle region 6. In this aspect of the mouth 5, it is possible to deliver a jet which is relatively wide.
According to FIG. 3 a, however, it is not only the depth which decreases, but also the width of the well 4′ towards the mouth 5′ in the nozzle region 6, namely at an angle of 7 to 8�, as a maximum (see the diffusor theory). As a result, a heavily accelerated jet is reached which is of a small width. In addition, the planar element 2′ has a chamfer 11 not only at the lower, wide longitudinal side, but has further chamfers 11′ at the narrow longitudinal sides so that it is pointed altogether towards the mouth 5′. This can be useful, e.g. for gel loaders or the reception in or delivery from microtitration plates (primarily those in a parallel arrangement).
FIG. 4 shows a proportioning disposable 1″ which is formed from a multiplicity of juxtaposed proportioning disposables 1′ as are shown in FIG. 2. Here, the proportioning disposables 1′ are integrally interconnected to form the proportioning disposable 1″.
Another particular feature of this volume-receiving part 2′″ is that it has a well 4″ with a nozzle portion 6″ which tapers towards the mouth 5″ more than it does in the embodiment of FIG. 3 b. Finally, the volume-receiving part 2′″ has its narrow longitudinal sides provided with steps 19 which face the end side having the mouth 5″. The narrow longitudinal sides 11″ extending from the steps 19 to the end side having the mouth 5″ enclose an angle which is more acute than that of the embodiment of FIG. 3 b. This volume-receiving part 2′″ is fitted with a membrane sheeting which exactly fits onto the shoulder 18 without covering the code 14 and the recesses 12. The upper surface of the membrane sheeting and that of the adjacent portion of the volume-receiving part 2′″ are at the same level. Then, the membrane sheeting and the portion of the volume-receiving part 2′″ which is adjacent at the same level are covered with a covering sheeting the outer contour of which exactly corresponds to that of the regions to be covered.
FIG. 6 shows a volume-receiving part 2 IV which is composed of parallel juxtaposed volume-receiving parts 2′″ which are integrally connected to each other. In accordance with the width of each volume-receiving part 2′″ which is 2.25 mm the distance between adjoining mouths 5″ or channels is 2.25 mm. This adjusts the volume-receiving part to the grid distance of the marketable microtitration plates having 1,536 wells (32�48 wells). However, the number and distance of the individual channels can be generally chosen at will.
FIG. 7 shows a parallelization by arranging several disposables 1′″ on top of each other (by a pile-up).
FIG. 8 shows how to superpose proportioning disposables 1 IV on the basis of the volume-receiving part 2 IV, which is shown in FIG. 6, in a roughly schematic way. Again, the proportioning disposables 1 IV are of different lengths in order to allow an access to the secondary wells 8. However, they are disposed in a common plane at the mouths 5″.
FIG. 9 illustrates how to connect a proportioning disposable 1 having a line 20 to a displacement device 21 which is drawn at a reduced scale. The line 20 sealingly rests on the upper surface of the of the covering sheeting 3 via an O-ring 22 with the O-ring 22 surrounding the passage 16. This connects the line 20 to the well 4 of the disposable 1 via the secondary well 8 and the channel 7.
FIG. 13 shows various structural elements which can be formed in order to increase the surface and/or stimulate turbulence and/or produce a shear force on a wall of a well of a disposable. Preferably, several elements of one of the types shown or several types are produced at the bottom of the well of one of the previously explained volume-receiving parts.
FIG. 17 shows a volume-receiving part 2 X of a centrifuging/filtration disposable. It is composed of two halves which are arranged in a specular symmetry with respect to a transverse middle plane and one of which is tinted dark and the other of which is tinted bright in the drawing for reasons of clarity. The two halves correspond to the half which is the left-hand one of the volume-receiving part 2 of FIG. 1 in the drawing.
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Ltd.Dispensing utensil* Cited by examinerClassifications U.S. Classification422/500, 435/288.5, 422/547, 422/501International ClassificationB01L3/02, G01N35/00, B01L3/00Cooperative ClassificationB01L3/502746, B01L3/502715, G01N2035/00237, B01L3/0241European ClassificationB01L3/5027B, B01L3/02DLegal EventsDateCodeEventDescriptionJan 14, 2002ASAssignmentOwner name: EPPENDORF AG, GERMANYFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HUSAR, DIETER;REEL/FRAME:012504/0369Effective date: 20020114Aug 20, 2009FPAYFee paymentYear of fee payment: 4Mar 7, 2013FPAYFee paymentYear of fee payment: 8RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services