Source: http://www.google.com/patents/US7910580?dq=4,923,986
Timestamp: 2016-10-24 02:43:21
Document Index: 756492624

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60']

Patent US7910580 - Enhancement of effectiveness of 5-Fluorouracil in treatment of tumor ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsTumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof....http://www.google.com/patents/US7910580?utm_source=gb-gplus-sharePatent US7910580 - Enhancement of effectiveness of 5-Fluorouracil in treatment of tumor metastases and cancerAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS7910580 B2Publication typeGrantApplication numberUS 12/016,294Publication dateMar 22, 2011Priority dateJun 4, 1999Fee statusPaidAlso published asUS7345039, US9012444, US20040087579, US20080114011, US20110172213Publication number016294, 12016294, US 7910580 B2, US 7910580B2, US-B2-7910580, US7910580 B2, US7910580B2InventorsH. Paul Redmond, Rolf W. PfirrmannOriginal AssigneeEd. Geistlich Soehne Ag Fuer Chemische IndustrieExport CitationBiBTeX, EndNote, RefManPatent Citations (113), Non-Patent Citations (134), Classifications (19), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetEnhancement of effectiveness of 5-Fluorouracil in treatment of tumor metastases and cancer
US 7910580 B2Abstract
Tumor growth and metastases in cancer patients are inhibited by administration of a combination therapy including effective amounts of 5-Fluorouracil and a methylol transfer agent such as taurolidine, taurultam or mixtures thereof.
8. The method of claim 1 wherein said agent is administered at a dosage of about 10-20 grams. Description
The present application is a continuation of pending U.S. application Ser. No. 10/660,798, filed Sep. 12, 2003, which is a continuation-in-part of U.S. application Ser. No. 10/281,138, filed Oct. 28, 2002, now U.S. Pat. No. 6,815,441, which is a continuation-in-part of U.S. application Ser. No. 09/993,896, filed Nov. 27, 2001, which claims the benefit of U.S. Provisional Application No. 60/253,138, filed Nov. 28, 2000. U.S. application Ser. No. 10/281,138 is a divisional of U.S. application Ser. No. 09/583,902, filed Jun. 1, 2000, now U.S. Pat. No. 6,479,481 B1, which claims the benefit of U.S. Provisional Application No. 60/182,200, filed Feb. 14, 2000, U.S. Provisional Application No. 60/174,607, filed Jan. 5, 2000, U.S. Provisional Application No. 60/167,681, filed Nov. 29, 1999, U.S. Provisional Application No. 60/151,050, filed Aug. 27, 1999 and U.S. Provisional Application No. 60/137,421, filed Jun. 4, 1999.
In accordance with the present invention, tumor growth and metastasis is inhibited in a cancer patient by administering to said patient a combination therapy comprising effective amounts of 5-FU and a methylol transfer agent.
It has surprisingly been found that methylol transfer agents such as taurolidine and taurultam substantially enhance or augment the antineoplastic effects of 5-FU in a combination therapy for inhibiting tumor metastases and treating cancer in patients. Such methylol transfer agents also substantially reduce the toxic side effects of 5-FU.
The human colo-rectal cell lines SW 480 (primary), SW 620 (metastatic) and W 707 (metastatic) were incubated with the following: culture medium (control), taurolidine at 5, 10, 25, 50 and 100 μg/ml doses, and 5-Fluorouracil (5-FU) at 5, 10, 25, 50 and 100 μM doses. 5-FU was tested alone, and together with taurolidine. Cell proliferation, apoptosis and cell cycle were assessed.
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Surg. 2000, 166: pp. 361-366.Classifications U.S. Classification514/223.8, 514/274International ClassificationA61K31/54, A61K31/505, A61K38/20, A61K31/549, A61K38/21, A61K45/06, A61K31/00Cooperative ClassificationA61K31/54, A61K31/549, A61K45/06, A61K31/00, A61K31/505European ClassificationA61K31/505, A61K45/06, A61K31/54, A61K31/549, A61K31/00Legal EventsDateCodeEventDescriptionSep 18, 2014FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services