Source: https://patents.google.com/patent/US10203521B2/en
Timestamp: 2019-04-22 11:42:37
Document Index: 663926461

Matched Legal Cases: ['arts 301', 'arts 301', 'art 301', 'art 301', 'arts 301', 'art 301', 'art 301']

US10203521B2 - Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients - Google Patents
Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients Download PDF
US10203521B2
US10203521B2 US14/612,029 US201514612029A US10203521B2 US 10203521 B2 US10203521 B2 US 10203521B2 US 201514612029 A US201514612029 A US 201514612029A US 10203521 B2 US10203521 B2 US 10203521B2
US14/612,029
US20150146162A1 (en
2013-03-15 Priority to US13/833,967 priority Critical patent/US8974055B2/en
2015-02-02 Application filed by Johnson and Johnson Vision Care Inc filed Critical Johnson and Johnson Vision Care Inc
2015-02-02 Priority to US14/612,029 priority patent/US10203521B2/en
2015-05-28 Publication of US20150146162A1 publication Critical patent/US20150146162A1/en
2019-02-12 Publication of US10203521B2 publication Critical patent/US10203521B2/en
The present invention, as described above and as further defined by the claims below, provides methods for forming an Ophthalmic Lens that encapsulates a Rigid Insert, wherein the Rigid Insert may be tailored to correct specific astigmatic characteristics of an eye and apparatus for implementing such methods, as well as Ophthalmic Lenses formed with the Rigid Inserts.
This application is a continuation of, and claims priority to, U.S. patent application Ser. No. 13/833,967, filed Mar. 15, 2013, published Sep. 18, 2014, as US20140268021, the entire contents of which are hereby incorporated by reference.
This invention describes methods, apparatus, and devices related to encapsulation aspects related to Ophthalmic Devices and, more specifically, in some embodiments, the sealing and encapsulation aspects in the fabrication of a contact lens for astigmatism.
Traditionally, an Ophthalmic Device, such as a Contact Lens or an intraocular Lens, included a biocompatible device with a corrective, cosmetic, or therapeutic quality. A Contact Lens, for example, can provide one or more of vision-correcting functionality, cosmetic enhancement, and therapeutic effects. The physical characteristics of the Ophthalmic Lens provide each function. A design incorporating a refractive quality into an Ophthalmic Lens can provide a vision-corrective function. A pigment incorporated into the Ophthalmic Lens can provide a cosmetic enhancement. An active agent incorporated into an Ophthalmic Lens can provide a therapeutic functionality.
Astigmatism is a common optical defect that is often the result of irregular or toric curvature of the cornea or lens of the eye. As a result, correcting vision for patients with astigmatism requires a more complex solution than the typical Contact Lens. More recently, it is desirable therefore to have additional methods and apparatus conducive to the formation of Ophthalmic Lenses that may correct vision in astigmatic patients. Recently, Rigid Inserts have been included in Ophthalmic Lenses, wherein the Rigid Insert may add functionality to the Ophthalmic Lens. Novel methods, devices, and apparatus relating to the sealing and encapsulation of a Rigid Insert within an Ophthalmic Lens are therefore important.
Accordingly, the present invention includes innovations relating to an Ophthalmic Lens device with a Rigid Insert capable of masking astigmatism, the Ophthalmic Lens device comprising a lens comprising a biocompatible material, wherein the biocompatible material allows for placement of the Ophthalmic Lens on an eye; a Rigid Insert, wherein the lens encapsulates the Rigid Insert; and a feature capable of correcting astigmatic vision, wherein the feature is located on one or both of the lens and the Rigid Insert. In some embodiments, the biocompatible material may comprise a polymerized Reactive Monomer Mixture, including, for example, a hydrogel.
The Rigid Insert may include a plurality of zones, wherein each zone mirrors an astigmatic characteristic of the eye. In some embodiments, each zone may comprise a different material, wherein each material enhances the effectiveness of the zone. The Rigid Insert may include a three-dimensional topography, for example, through a thermoforming process. The three-dimensional topography may mirror the astigmatic characteristic of the eye. The three-dimensional topography of the Rigid Insert may be enhanced by a three-dimensional topography of the lens.
The Ophthalmic Lens may further comprise a Stabilizing Feature capable of orienting the Ophthalmic Lens on the eye, wherein the orientation is capable of aligning the plurality of zones with the astigmatic characteristics of the eye. The Stabilizing Feature may be separate from the Rigid Insert or may be included in the Rigid Insert, for example, through a thermoforming process. In some embodiments, the Stabilizing Feature may alter a front curve surface of the Ophthalmic Lens. In others, the Stabilizing Feature may add mass to the Ophthalmic Lens, wherein the mass is sufficient to ballast the Ophthalmic Lens. The Stabilizing Feature may further comprise a visual orientation cue, wherein the visual orientation cue is visible to the user and allows the user to see how the Ophthalmic Lens should be oriented prior to placement on the eye.
In some embodiments, the Ophthalmic Lens may provide multiple functionalities, in addition to correcting astigmatism. For example, the lens may further comprise a polarizing function or a cosmetic function, such as a patterned coloration. In some embodiment, the Rigid Insert may further comprise an active agent, wherein the active agent is capable of dissolving into an ophthalmic environment on the eye.
FIG. 1 illustrates an exemplary embodiment of an Ophthalmic Lens with a fully encapsulated Rigid Insert, wherein the Ophthalmic Lens may correct vision in astigmatic patients.
FIG. 2 illustrates an alternate FIG. 1 illustrates exemplary Mold assembly apparatus components that may be useful in implementing some embodiments of the present invention.
FIG. 3 illustrates exemplary Mold assembly apparatus components that may be useful in implementing some embodiments of the present invention.
The present invention includes methods and apparatus for manufacturing an Ophthalmic Lens with a Rigid Insert, wherein the Rigid Insert corrects vision in astigmatic patients. In addition, the present invention includes the resulting Ophthalmic Lens with the Rigid Insert. In general, according to some embodiments of the present invention, a Rigid Insert may be integrated into an Ophthalmic Lens via automation that places a Rigid Insert in a desired location relative to a Mold part used to fashion the Ophthalmic Lens.
Currently, Ophthalmic Lenses exist to correct astigmatism. For example, rigid gas permeable lenses may be placed over the cornea, and a tear layer will form between the lens and the eye. The rigid gas permeable lens essentially acts as the new cornea, which may be designed to mimic the curvature of a nonastigmatic eye. This technique is considered masking. However, the typical rigid gas permeable lens is uncomfortable and expensive.
Soft contact lenses provide a more comfortable and less expensive alternative. Unlike with an RGP, a tear layer may not form between the eye and the lens; so, a soft contact lens may be tailored to mirror the astigmatic characteristics of the eye. The lens may contain varied powers and angles of refraction to correct each portion of the eye. However, because the lens is soft, the lens naturally conforms, to some extent, to shape of the eye. This reduces the effectiveness of the lens, and users often complain of blurriness or double vision.
The issues with comfort and effectiveness of either solution are exacerbated in patients with severe astigmatism. Accordingly, the present invention provides a novel alternative to correcting vision in astigmatic patients. An Ophthalmic Lens that may include a Rigid Insert is described, and more specifically, where an encapsulated Rigid Insert may provide the correction to astigmatism.
Adhesion Promotion: as used herein refers to a process that increases the adhesive tendencies between two surfaces, such as, for example, between a Rigid Insert and an encapsulant.
Mold: as used herein refers to a rigid or semi-rigid object that may be used to form Ophthalmic Lenses from uncured formulations. Some preferred Molds include two Mold parts forming a front curve Mold and a back curve Mold.
Precure: as used herein refers to a process that partially cures a mixture. In some embodiments, a precuring process may comprise a shortened period of the full curing process. Alternatively, the precuring process may comprise a unique process, for example, by exposing the mixture to different temperatures and wavelengths of light than may be used to fully cure the material.
Predose: as used herein refers to the initial deposition of material in a quantity that is less than the full amount that may be necessary for the completion of the process. For example, a predose may include a quarter of the necessary substance.
Postdose: as used herein refers to a deposition of material in the remaining quantity, after the predose, that may be necessary for the completion of the process. For example, where the predose includes a quarter of the necessary substance, a subsequent postdose may provide the remaining three quarters of the substance.
Rigid Insert: as used herein refers to an insert that maintains a predefined topography. When included in a Contact Lens, the Rigid Insert may contribute to the functionality and/or modulus of the Lens. For example, varying topography of or densities within the Rigid Insert may define zones, which may correct vision in users with astigmatism. The Rigid Insert may be flexible, for example the Rigid Insert may flex during insertion and/or removal of the lens.
Stabilizing Feature: as used herein refers to a physical characteristic that stabilizes an Ophthalmic Device to a specific orientation on the eye, when the Ophthalmic Device is placed on the eye. In some embodiments, the Stabilizing Feature may add sufficient mass to ballast the Ophthalmic Device. In some embodiments, the Stabilizing Feature may alter the front curve surface, wherein the eyelid may catch the Stabilizing Feature and the user may reorient the Lens by blinking. Such embodiments may be enhanced by including Stabilizing Features that may add mass. In some exemplary embodiments, Stabilizing Features may be a separate material from the encapsulating biocompatible material, may be an insert formed separately from the molding process, or may be included in the Rigid Insert or Media Insert.
Swellable Index: as used herein refers to the expandability or expanding tendency of a specific material during the manufacturing of an Ophthalmic Lens.
Proceeding to FIG. 1, an exemplary embodiment Ophthalmic Lens 100 with a Rigid Insert 110, wherein the Rigid Insert 110 includes physical attributes that correct vision for patients with astigmatism, is illustrated. In some embodiments, a Rigid Insert 110 may mirror the astigmatic characteristics of the eye. For example, the Rigid Insert 110 may include a first zone 111 with a first power and angle of refraction and a second zone 112 with a second power and angle of refraction. In some embodiments, the first zone 111 may not be located exactly in the center of the eye, and the second zone 112 may not be radially symmetrical.
In such embodiments, Stabilizing Features 120 may be necessary to properly orient the Ophthalmic Lens 100 on the eye. The Stabilizing Features 120 may comprise a material that is different from the encapsulating Reactive Monomer Mixture. In some embodiments, the material for the Stabilizing Features 120 may be placed on a Front Curve Mold Piece prior to placement of the Rigid Insert 110. Alternatively, the material may be injected into the Ophthalmic Lens 100 after the Rigid Insert 110 has been placed between the Front Curve Mold Piece and the Back Curve Mold Piece.
As shown in cross section, the Stabilizing Feature 120 may orient the Ophthalmic Lens 100 on the eye by adding sufficient mass to anchor the Ophthalmic Lens 100 to prevent rotation on the eye. In some alternative embodiments, the Stabilizing Feature 110 may comprise a material with a different swellable index than the encapsulating RMM. In such embodiments, the Stabilizing Feature 110 may swell during the process of forming the Ophthalmic Lens 100, wherein the swelling allows the Stabilizing Feature 110 to alter the front surface topography of the Ophthalmic Lens 100. When placed on the eye, the eyelid may catch the Stabilizing Feature 110, and the user may reorient the lens by blinking. To further facilitate placement on the eye, the Stabilizing Feature 110 may contain a tint, wherein the user may see how the Ophthalmic Lens 100 may orient on the eye prior to placement.
In some embodiments a Rigid Insert may be formed by thermoforming an aligned and held sheet into a three-dimensional shape that may replicates the surface of a thermoforming mold piece. The resulting piece may be cut from the thin sheet of material. By positioning the Rigid Insert within a cavity defined by front and back curve mold pieces and surrounding the insert with Reactive Monomer Mixture an Ophthalmic Lens may be formed. During the process of cutting out insert pieces from thermoforming material, alignment features may be cut into the insert piece such as notches, grooves, or flats for example. These features may be used to align the insert piece or formed ophthalmic insert devices in subsequent processing.
Proceeding to FIG. 2, an alternative embodiment of an Ophthalmic Lens 200 with a Rigid Insert 210, wherein the Rigid Insert 210 includes physical attributes to correct vision in astigmatic patients, is illustrated. In patients with severe astigmatism, the Rigid Insert 210 may include a complex configuration of zones 211-213, wherein each zone 211-213 corrects vision for a specific portion of the eye. The Rigid Insert 210 may be fully encapsulated in the Ophthalmic Lens 200 and may not have direct contact with the eye. Accordingly, in some embodiments, the Rigid Insert 210 may comprise a variety of material, wherein the materials may not be biocompatible. For example, a first zone 211 may include a different material from a second 212 or third 213 zone. The properties of each material may increase the effectiveness of vision correction for each zone 211-213 or the properties alone may be sufficient to correct the astigmatic characteristics. The properties may include, for example, density or refractive index.
In some embodiments, the Rigid Insert 210 may be formed through a thermoforming process. For example, in embodiments where each zone 211-213 comprises a unique material, a thin sheet may be regionally coated with each material. The thin sheet or a Rigid Insert cut from the thin sheet may be thermoformed to include a Three-dimensional Surface, wherein the topography of Three-dimensional Surface of the Rigid Insert contributes to the correction of the astigmatic characteristics of the eye. In some embodiments, the Three-dimensional Surface may be sufficient to create the necessary zones 211-213.
In some embodiments of Ophthalmic Lenses 200 that include Rigid Inserts 210 with multiple zones, and particularly where the Rigid Insert 210 includes complex variation, Stabilizing Features 220 may be included with the Rigid Insert 210. This may allow for precise alignment between the Stabilizing Features 220 and the Rigid Insert 210. In some specific embodiments where the Rigid Insert 210 may be thermoformed, the Rigid Insert may be cut from the thin sheet to include the Stabilizing Features 220, as shown in cross section where the Stabilizing Feature 220 extends from the Rigid Insert 220.
Similar to FIG. 1, the Stabilizing Feature 220 may alter the front surface topography so the user may reorient the Ophthalmic Lens 200 by blinking, or, in some embodiments, the Stabilizing Feature 220 may add sufficient mass to orient the Ophthalmic Lens 200 on the eye. Some other embodiments may include a combination of mass and altered front surface topography. The Stabilizing Features 220 may include further characteristics that may assist the user in properly orienting the Ophthalmic Lens 200. For example, the Stabilizing Feature 220 may include an inscription or tinting to indicate to the user how the Ophthalmic Lens 200 may be placed on the eye.
In some embodiments, other passive elements may be included with the Rigid Insert 210. In some embodiments, the Rigid Insert 210 may include polarizing elements that may reduce glare, which may increase vision sharpness. In some embodiments, the Rigid Insert 210 may include a printed pattern that may add cosmetic functionality, including a concealment of the zones 211-213 on the Rigid Insert 210. In some embodiments, the Rigid Insert 210 may include an active agent that may dissolve when the Ophthalmic Lens 200 is placed on the eye. Embodiments where the active agent is a medicament may be particularly significant where the astigmatism is caused by damage to the eye.
Proceeding to FIG. 3, exemplary processing steps for forming an Ophthalmic Lens 309 with a Rigid Insert 304, wherein the Rigid Insert 304 is encapsulated and may be capable of correcting astigmatic vision, are illustrated. Exemplary materials and curing specifications are included in Table 1, but other materials and polymerization techniques may be apparent and are within the scope of the described inventive art. At 310, a front curve Mold 301 may be predosed with Reactive Monomer Mixture 303. In some embodiments, Stabilizing Features 302 may be deposited on the front curve Mold 301 or on the predosed RMM 303.
At 320, a Rigid Insert 304 may be placed proximate to the front curve Mold 304 and in contact with the predosed RMM, wherein the placement forms a front curve assembly 301-304. In embodiments where the Stabilizing Feature 302 is separate from the Rigid Insert 304, the Rigid Insert 304 may be aligned with the Stabilizing Feature 302 and placed to allow proper orientation of the Ophthalmic Lens 309 when the Ophthalmic Lens 309 is placed on an eye.
At 330, the front curve assembly 301-304 may be postdosed with Reactive Monomer Mixture 305, wherein the predose amount 303 and the postdose amount 305 may fully encapsulate the Rigid Insert 304 and properly form an Ophthalmic Lens 308. At 340, a back curve Mold 306 may be placed proximate to the front curve Mold 301, wherein the front curve Mold 301 and the back curve Mold 306 may form a lens-forming cavity 308. The lens-forming cavity 308 may combine the postdosed RMM 305 and predosed RMM 303, which may allow the RMM 307 to fully encapsulate the Rigid Insert 304.
In some embodiments, the RMM 307 may adhere to or at least partially encapsulate the Stabilizing Features 303. The front curve and back curve assembly 301-307 may be polymerized, for example through a curing process, to form the Ophthalmic Lens 309. At 350, the Ophthalmic Lens 309 may be removed from the molding apparatus 301, 306.
Epoxy One Component - high temp cure, excellent adhesive,
Systems biocompatible
Silicone One Component - resistance to humidity, high
Systems flexibility, Insulation, Optical Clarity
Referring back to FIG. 3, exemplary processing steps for forming an Ophthalmic Lens 309 with a Rigid Insert 304, wherein the Rigid Insert 304 is encapsulated and may be capable of correcting astigmatic vision, are illustrated. As used herein, a Mold apparatus 301, 306 may include a plastic formed to shape a lens-forming cavity 308 into which a Lens-Forming Mixture 307 may be dispensed, and, upon reaction or cure of the Lens-Forming Mixture 307, an Ophthalmic Lens 309 of a desired shape is produced. The combination of Mold parts 301, 306 is preferably temporary, wherein, upon formation of the Ophthalmic Lens 309, the Mold parts 301, 306 may be separated for removal, at 350, of the Ophthalmic Lens 309.
At least one Mold part 301, 306 may have at least a portion of its surface in contact with the Lens-Forming Mixture 307 so that upon reaction or cure of the Lens-Forming Mixture 307 the surface provides a desired shape and form to the portion of the Ophthalmic Lens with which it is in contact. The same is true of at least one other Mold part 301, 306.
Thus, for example, in an exemplary embodiment a Mold apparatus 301, 306 is formed from two parts 301, 306, a female concave piece (front curve Mold) 301 and a male convex piece (back curve Mold) 306 with a cavity 308 formed between them. The portion of the concave surface that makes contact with a Lens-Forming Mixture 307 has the curvature of the front curve of an Ophthalmic Lens 309.
Said portion is sufficiently smooth and formed such that the surface of an Ophthalmic Lens 309, formed by polymerization of the Lens-Forming Mixture 307 that is in contact with the concave surface, is optically acceptable. In some embodiments, the front curve Mold 301 may also have an annular flange integral to and surrounding a circular circumferential edge that extends from the front curve Mold 301 in a plane normal to the axis and also extends from the flange (not shown).
A Lens-Forming Surface can include a surface with an optical-quality surface finish, which indicates that it is sufficiently smooth and formed so that an Ophthalmic Lens surface fashioned by the polymerization of a Lens-Forming Mixture 308 in contact with the molding surface is optically acceptable. Further, in some embodiments, the Lens-Forming Surfaces of the Mold pieces 301, 306 may have a geometry that is necessary to impart to the Ophthalmic Lens surface the desired optical characteristics, including, but not limited to, spherical, aspherical, and cylinder power; wave front aberration correction; corneal topography correction; and combinations thereof. One ordinarily skilled in the art will recognize that characteristics other than those discussed may also be included within the scope of the invention.
Some additional embodiments include a Rigid Insert 304 that may be fully encapsulated within a hydrogel matrix. A Rigid Insert 304 may be manufactured, for example, using microinjection molding technology. Embodiments can include, for example, a poly(4-methylpent-1-ene) copolymer resin with a diameter of between about 6 mm to 10 mm and a front surface radius of between about 6 mm and 10 mm and a rear surface radius of between about 6 mm and 10 mm and a center thickness of between about 0.050 mm and 0.5 mm. Some exemplary embodiments include an insert with diameter of about 8.9 mm and a front surface radius of about 7.9 mm and a rear surface radius of about 7.8 mm and a center thickness of about 0.100 mm and an edge profile of about 0.050 radius. One exemplary micromolding machine can include the Microsystem 50 five-ton system offered by Battenfield Inc. Some or all of the sealing features, including, but not limited to, grooves, slots, lips, and knife edges may be formed during the molding process or formed later by subsequent processing of the result of the molding process.
The Rigid Insert 304 may be placed in a Mold part 301, 306 utilized to form an Ophthalmic Lens 308. Mold part 301, 306 material can include, for example, a polyolefin of one or more of the following: polypropylene, polystyrene, polyethylene, polymethyl methacrylate, and modified polyolefins. Other Molds can include a ceramic or metallic material.
In some embodiments, an Ophthalmic Lens type may include an Ophthalmic Lens that includes a silicone-containing Component. A silicone-containing Component is one that contains at least one [—Si—O—] unit in a monomer, macromer, or prepolymer. Preferably, the total silicone and attached oxygen are present in the silicone-containing Component in an amount greater than about 20 weight percent, and more preferably greater than 30 weight percent of the total molecular weight of the silicone-containing Component. Useful silicone-containing Components preferably comprise polymerizable functional groups such as acrylate, methacrylate, acrylamide, methacrylamide, vinyl, N-vinyl lactam, N-vinylamide, and styryl functional groups.
As used herein, monovalent reactive groups are groups that can undergo free radical and/or cationic polymerization. Non-limiting examples of free radical reactive groups include (meth)acrylates, styryls, vinyls, vinyl ethers, C1-6alkyl(meth)acrylates, (meth)acrylamides, C1-6alkyl(meth)acrylamides, N-vinyllactams, N-vinylamides, C2-12alkenyls, C2-12alkenylphellyls, C2-12alkenylnaphthyls, C2-6alkenylphenylC1-6alkyls, O-vinylcarbamates, and O-vinylcarbonates. Non-limiting examples of cationic reactive groups include vinyl ethers or epoxide groups and mixtures thereof. In one embodiment the free radical reactive groups comprise (meth)acrylate, acryloxy, (meth)acrylamide, and mixtures thereof.
In one embodiment b is 0, one R1 is a monovalent reactive group, and at least three R1 are selected from monovalent alkyl groups having 1 to 16 carbon atoms or, in another embodiment, from monovalent alkyl groups having 1 to 6 carbon atoms. Non-limiting examples of silicone Components of this embodiment include 2-methyl-2-hydroxy-3-[3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propoxy]propyl ester (“SiGMA”), 2-hydroxy-3-methacryloxypropyloxypropyl-tris(trimethylsiloxy)silane, 3-methacryloxypropyltris(trimethylsiloxy)silane (“TRIS”), 3-methacryloxypropylbis(trimethylsiloxy)methylsilane, and 3-methacryloxypropylpentamethyl disiloxane.
wherein R11 independently denotes an alkyl or fluoro-substituted alkyl group having 1 to 10 carbon atoms, which may contain ether linkages between carbon atoms; y is at least 1; and p provides a moiety weight of 400 to 10,000; each of E and E1 independently denotes a polymerizable unsaturated organic radical represented by Formula VIII
Other silicone-containing Components suitable for use in this invention include macromers containing polysiloxane, polyalkylene ether, diisocyanate, polyfluorinated hydrocarbon, polyfluorinated ether, and polysaccharide groups; polysiloxanes with a polar fluorinated graft or side group having a hydrogen atom attached to a terminal difluoro-substituted carbon atom; hydrophilic siloxanyl methacrylates containing ether and siloxanyl linkages and crosslinkable monomers containing polyether and polysiloxanyl groups. Any of the foregoing polysiloxanes can also be used as the silicone-containing Component in this invention.
1. An ophthalmic lens device for placement on an eye comprising:
a lens comprising a biocompatible material; and
a rigid insert encapsulated within said lens and comprising a plurality of zones wherein at least one of the plurality of zones mirrors an astigmatic characteristic of the eye and wherein said zones comprise differing refractive indices; and
wherein the rigid insert comprises one or more materials having different densities among the plurality of zones.
2. The ophthalmic lens device of claim 1, wherein said lens has a three-dimensional topography.
3. The ophthalmic lens device of claim 2, wherein the three-dimensional topography of the lens enhances a corrective property of the rigid insert.
4. The ophthalmic lens device of claim 2, wherein said stabilizing feature orients the lens device to align the three-dimensional topography of the rigid insert with the astigmatic vision characteristics of the eye.
5. The ophthalmic lens device of claim 1, wherein the stabilizing feature alters the front curve surface of the lens.
6. The ophthalmic lens device of claim 5, wherein the stabilizing feature projects from the front curve surface of the lens.
7. The ophthalmic lens device of claim 1, wherein the stabilizing feature adds sufficient mass to ballast the ophthalmic lens device.
8. The ophthalmic lens device of claim 1, wherein at least one of the rigid insert and lens provide polarization.
9. The ophthalmic lens device of claim 1, wherein at least one of the rigid insert and lens comprises a region of coloration.
10. The ophthalmic lens device of claim 1, wherein said rigid insert further comprises an active agent.
US14/612,029 2013-03-15 2015-02-02 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients Active US10203521B2 (en)
US13/833,967 US8974055B2 (en) 2013-03-15 2013-03-15 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients
US14/612,029 US10203521B2 (en) 2013-03-15 2015-02-02 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients
US13/833,967 Continuation US8974055B2 (en) 2013-03-15 2013-03-15 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients
US20150146162A1 US20150146162A1 (en) 2015-05-28
US10203521B2 true US10203521B2 (en) 2019-02-12
ID=50277117
US13/833,967 Active 2033-04-27 US8974055B2 (en) 2013-03-15 2013-03-15 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients
US14/612,029 Active US10203521B2 (en) 2013-03-15 2015-02-02 Method and apparatus for encapsulating a rigid insert in a contact lens for correcting vision in astigmatic patients
US (2) US8974055B2 (en)
EP (1) EP2778761A1 (en)
JP (1) JP2014182394A (en)
KR (1) KR20140113536A (en)
CN (1) CN104044239B (en)
AU (1) AU2014201544B2 (en)
BR (1) BR102014006241A2 (en)
CA (1) CA2846672A1 (en)
HK (1) HK1202166A1 (en)
IL (1) IL231364D0 (en)
RU (1) RU2647988C2 (en)
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TW (1) TWI587031B (en)
DE102017007219A1 (en) * 2016-12-13 2018-06-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. A process for preparing a transmitiven or reflective optics and lens
EP0613694A1 (en) 1993-03-02 1994-09-07 JOHNSON &amp; JOHNSON VISION PRODUCTS, INC. Ophthalmic lens with anti-toxin agent
JPH11174388A (en) 1997-12-12 1999-07-02 Hoya Health Care Kk Toric contact lens
WO2002029446A2 (en) 2000-10-05 2002-04-11 Paragon Vision Contact lens and methods of manufacture
WO2004010204A1 (en) 2002-07-19 2004-01-29 Johnson & Johnson Vision Care, Inc. Rotationally stabilized contact lenses
JP2009008848A (en) 2007-06-27 2009-01-15 Nippon Optical:Kk Contact lens and its manufacturing method
EP2512777B1 (en) 2009-12-14 2014-02-12 Essilor International (Compagnie Générale D'Optique) Process for producing a curved substrate covered with a film
2013-03-15 US US13/833,967 patent/US8974055B2/en active Active
2014-03-06 IL IL231364A patent/IL231364D0/en unknown
2014-03-11 SG SG10201400552XA patent/SG10201400552XA/en unknown
2014-03-13 TW TW103108935A patent/TWI587031B/en active
2014-03-14 KR KR1020140030308A patent/KR20140113536A/en active Search and Examination
2014-03-14 CA CA2846672A patent/CA2846672A1/en active Pending
2014-03-14 JP JP2014051291A patent/JP2014182394A/en active Pending
2014-03-14 CN CN201410095530.9A patent/CN104044239B/en active IP Right Grant
2014-03-14 EP EP14160109.6A patent/EP2778761A1/en active Pending
2014-03-14 RU RU2014109981A patent/RU2647988C2/en active
2014-03-14 AU AU2014201544A patent/AU2014201544B2/en active Active
2014-03-17 BR BRBR102014006241-6A patent/BR102014006241A2/en active Search and Examination
2015-02-02 US US14/612,029 patent/US10203521B2/en active Active
2015-03-16 HK HK15102619.0A patent/HK1202166A1/en unknown
European Search Report for Application No. EP 14 16 0109 Date of Completion of Report Jun. 30, 2014.
Singapore Search Report 10201400552X Date of submission of the request to the Intellectual Property Office of Singapore: Sep. 24, 2014: Date of actual completion of the search: Jan. 28, 2015: Date Johnson & Johnson Received report from Singapore: 2015.
US20140268021A1 (en) 2014-09-18
US8974055B2 (en) 2015-03-10
TW201441718A (en) 2014-11-01
CA2846672A1 (en) 2014-09-15
AU2014201544A1 (en) 2014-10-02
US20150146162A1 (en) 2015-05-28
CN104044239B (en) 2018-12-28
BR102014006241A2 (en) 2015-01-06
RU2647988C2 (en) 2018-03-21
AU2014201544B2 (en) 2017-11-30
TWI587031B (en) 2017-06-11
HK1202166A1 (en) 2015-09-18
EP2778761A1 (en) 2014-09-17
JP2014182394A (en) 2014-09-29
KR20140113536A (en) 2014-09-24
IL231364D0 (en) 2014-08-31
SG10201400552XA (en) 2014-10-30
CN104044239A (en) 2014-09-17
RU2014109981A (en) 2015-09-20
JP6385987B2 (en) 2018-09-05 The method for forming an ophthalmic lens with an embedded microcontroller
EP2812750A1 (en) 2014-12-17 Energized ophthalmic lens including stacked integrated components
RU2605419C2 (en) 2016-12-20 Method for production of hydrogel ophthalmic devices with electronic elements
JP6316595B2 (en) 2018-04-25 Multi-piece insert device comprising an adhesive sealing portion for ophthalmic devices