Source: http://www.science.gov/topicpages/a/activities+appendixes+include.html
Timestamp: 2016-10-22 16:11:20
Document Index: 29449147

Matched Legal Cases: ['art 544', 'art 544', 'art 544', 'art 544', 'art 544', 'art 544', 'art 544', 'art 544', 'art 37', 'art 28', 'art 22', 'art 22', 'art 37', 'art 1125', 'art 37', 'art 37', 'art 37', 'art 552', 'art 552', 'art 440', 'art 440', '§ 254', '§ 254', '§ 254', 'art 1253', 'art 1253', 'art 1253', 'art 1253', 'art 1125', 'art 34', 'art 1125', 'art 34', '§ 981', 'art 255', 'art 32', 'art 32', 'art 32', 'art 32', 'art 32', 'art 37', 'art 37', 'art 45', 'art 45', 'art 45', 'art 45', 'art 230', '§\u2009215', 'art 215', 'art 225', 'art 220', 'art 881', 'art 881', 'art 881', 'art 881', 'art 881', 'art 881', 'art 881', 'art 300', 'art 300', '§ 300', 'art 45', 'art 45', '§ 215', 'art 215', 'art 225', 'art 220', 'art 160', 'art 160', 'art 160', 'art 510', 'art 589', 'art 510', 'art 589', 'art 589', 'art 510', 'art 589', 'art 589', 'art 290', 'art 290', 'art 290', 'art 290', 'art 290', 'art 290']

activities appendixes include: Topics by Science.gov
Sample records for activities appendixes include
Operational Control Procedures for the Activated Sludge Process: Appendix.
This document is the appendix for a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. Categories discussed include: control test data, trend charts, moving averages, semi-logarithmic plots, probability…
49 CFR Appendix C to Part 544 - Motor Vehicle Rental and Leasing Companies (Including Licensees and Franchisees) Subject to the...
... (Including Licensees and Franchisees) Subject to the Reporting Requirements of Part 544 C Appendix C to Part... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INSURER REPORTING REQUIREMENTS Pt. 544, App. C Appendix C to Part 544—Motor Vehicle Rental and Leasing Companies (Including Licensees and...
49 CFR Appendix C- to Part 544... - Appendix C- to Part 544 Motor Vehicle Rental and Leasing Companies (Including Licensees and...
... Leasing Companies (Including Licensees and Franchisees) Subject to the Reporting Requirements of Part 544... Franchisees) Subject to the Reporting Requirements of Part 544 Transportation Other Regulations Relating to... REPORTING REQUIREMENTS Pt. 544, App. C Appendix C— to Part 544 Motor Vehicle Rental and Leasing...
RBDMS (Risk Based Data Management System) is an oil and gas electronic data management system which stems from the idea developed from four previous projects conducted by the American Petroleum Institute (API) and the Ground Water Protection Council (GWPC). The first study studied oil and gas industry injection well corrosion. It included a methodology for assessing the probability of contaminating underground sources of drinking water (USDWs) via Class 2 injection well operations. A feasibility study was conducted to investigate if an electronic data management system could incorporate the methodology. A second feasibility study was conducted to test the methodology on a much small basis. The RBDMS effort then continued through a grant from DOE with a multi-task project consisting of an inventory and needs assessment of 25 oil and gas producing states pertaining to oil and gas production/regulatory activities, state geological/hydrogeological considerations, Class 2 underground injection activities, electronic data management needs and functional requirements, environmental risk assessment and management objectives, resultant benefit of a RBDMS, and various information and data required for the design and development of a RBDMS in individual states. This appendix contains the documentation for the use of the RBDMS.
30 CFR 254.28 - What information must I include in the “In situ burning plan” appendix?
... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What information must I include in the âIn situ burning planâ appendix? 254.28 Section 254.28 Mineral Resources BUREAU OF SAFETY AND ENVIRONMENTAL ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill...
32 CFR Appendix D to Part 37 - What Common National Policy Requirements May Apply and Need To Be Included in TIAs?
... rule about lobbying prohibitions, which is implemented by the DoD at 32 CFR part 28. The prohibitions apply to all financial assistance. Appendix A to 32 CFR part 22 includes a sample provision that you may... conditions, or assurances. Appendix B to 32 CFR part 22 lists national policy requirements that...
... 32 National Defense 1 2014-07-01 2014-07-01 false What Common National Policy Requirements May Apply and Need To Be Included in TIAs? D Appendix D to Part 37 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pt. 37, App. D Appendix D to Part...
... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and... Include When Purchasing Goods or Services Under a TIA? E Appendix E to Part 37 National Defense Department... INVESTMENT AGREEMENTS Pt. 37, App. E Appendix E to Part 37—What Provisions May a Participant Need To...
... 32 National Defense 1 2014-07-01 2014-07-01 false What Provisions May a Participant Need To Include When Purchasing Goods or Services Under a TIA? E Appendix E to Part 37 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pt. 37, App. E Appendix E to...
NatureScope, 1989
Includes a glossary, bibliography, reference books, children's books, cassettes, films, filmstrips, records, slides, videos, booklets, periodicals, posters, other activity sources, information sources, index, and areas of tropical rain forests. (Author/RT)
Contains a glossary of terms related to endangered species and lists reference books, children's books, audio-visual materials, software, and activity sources on the topics. Also identifies wildlife laws and explains what they mean. An index of issues of "Ranger Rick," which includes articles on endangered species, is included. (ML)
NatureScope, 1988
Provides a glossary and bibliography which includes a listing of the following: general reference books, field guides, children's books, films, filmstrips, slides, videos, coloring books, games, posters, software, activity sources, where to get more information, Ranger Rick Ocean Index, and a metric conversion chart. (RT)
48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities
... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Use of Collaborative Assistance Method for Title XII Activities F Appendix F to Chapter 7 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT Ch. 7, App. F Appendix F to Chapter 7—Use of Collaborative Assistance Method for Title XII Activities...
32 CFR Appendix D to Subpart M of... - Unauthorized Activities in Maneuver Training Areas
... Areas D Appendix D to Subpart M of Part 552 National Defense Department of Defense (Continued.... D Appendix D to Subpart M of Part 552—Unauthorized Activities in Maneuver Training Areas 1. Fort... camping outside of DPCA sites (camping on DPCA sites is open to DoD members only, per above)....
Presents: (1) a list of 23 questions about mammals (with answers); (2) a glossary with mammal-related words; and (3) a bibliography listing reference books, children's books, audiovisual aids, field guides, activity sources, and mammal-related articles appearing in "Ranger Rick" magazine. (ML)
..., 14 CFR Ch. III (the “Regulations”). This agreement applies to . In consideration of the mutual... Assumption of Responsibility for Permitted Activities C Appendix C to Part 440 Aeronautics and Space... FINANCIAL RESPONSIBILITY Pt. 440, App. C Appendix C to Part 440—Agreement for Waiver of Claims...
78 FR 78063 - Appendix 4 to Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for...
... RA) (78 FR 3824). We conducted the qualitative risk assessment to identify activity/ food... 16 and 121 Appendix 4 to Draft Qualitative Risk Assessment of Risk of Activity/ Food Combinations for... Draft Qualitative Risk Assessment of Risk of Activity/Food Combinations for Activities (Outside the...
Study Modules for Calculus-Based General Physics. [Includes Modules 41 and 42: Lenses and Mirrors; Relativity; and Appendix].
... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.28 What..., including provisions for ignition of an oil spill; (c) A discussion of environmental effects of an in...
... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.29 What...) Identify and include the dates of the training provided to members of the spill-response management...
... ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities § 254.24 What... include: (a) An inventory of spill-response materials and supplies, services, equipment, and...
..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities... inventory appendix” must include: (a) An inventory of spill-response materials and supplies,...
..., REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE OIL-SPILL RESPONSE REQUIREMENTS FOR FACILITIES LOCATED SEAWARD OF THE COAST LINE Oil-Spill Response Plans for Outer Continental Shelf Facilities... burning procedures, including provisions for ignition of an oil spill; (c) A discussion of...
Hematochezia due to Angiodysplasia of the Appendix
Choi, Je-Min; Lee, Seung-Hyun; Ahn, Byung-Kwon; Baek, Sung-Uhn
Common causes of lower gastrointestinal bleeding include diverticular disease, vascular disease, inflammatory bowel disease, neoplasms, and hemorrhoids. Lower gastrointestinal bleeding of appendiceal origin is extremely rare. We report a case of lower gastrointestinal bleeding due to angiodysplasia of the appendix. A 72-year-old man presented with hematochezia. Colonoscopy showed active bleeding from the orifice of the appendix. We performed a laparoscopic appendectomy. Microscopically, dilated veins were found at the submucosal layer of the appendix. The patient was discharged uneventfully. Although lower gastrointestinal bleeding of appendiceal origin is very rare, clinicians should consider it during differential diagnosis. PMID:27437394
... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...
... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...
... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...
... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Prior Approval for Enterprise Products... AGENCY ENTERPRISES PRIOR APPROVAL FOR ENTERPRISE PRODUCTS Pt. 1253, App. Appendix to Part 1253—Prior Approval for Enterprise Products—Instructions and Notice of New Activity Form ER02JY09.000...
... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and 12689 (3 CFR, 1989 Comp., p. 235), “Debarment and Suspension.” The Excluded Parties List System..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists...
... adoption at 2 CFR part 1125 of the OMB guidance implementing E.O.s 12549 (3 CFR, 1986 Comp., p. 189) and..., which are for substantive research program performance. B. Appendix A to 32 CFR part 34 lists seven... funds that takes place in connection with obtaining any Federal award. For further details, see 32...
32 CFR Appendix C to Subpart M of... - Authorized Activities for Maneuver Training Area Access
... RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville Pt. 552, Subpt. M, App... commercial use (AR 405-80) Installation service and maintenance (AR 420-74, FL Reg 350-30) Non-DoD personnel in transit on public-access routes (appendix B) non-commercial recreational use: Hunting, fishing...
Image Display and Manipulation System (IDAMS) program documentation, Appendixes A-D. [including routines, convolution filtering, image expansion, and fast Fourier transformation
Cecil, R. W.; White, R. A.; Szczur, M. R.
The IDAMS Processor is a package of task routines and support software that performs convolution filtering, image expansion, fast Fourier transformation, and other operations on a digital image tape. A unique task control card for that program, together with any necessary parameter cards, selects each processing technique to be applied to the input image. A variable number of tasks can be selected for execution by including the proper task and parameter cards in the input deck. An executive maintains control of the run; it initiates execution of each task in turn and handles any necessary error processing.
Overwater plume dispersion study: Appendix. Final report
Godden, D.; Hanna, S.; Scire, J.; Strimaitis, D.
The purpose of this study was to develop an air-quality modeling methodology to simulate the impact of emissions from oil exploration and production activities in California coastal waters. The study included the collection of data in a field program, and the analysis of the data to determine a relationship between Gaussian dispersion coefficients and overwater transport distance and meteorological variable observed near the source and the shoreline. This appendix contains data taken during the study.
Ordway, Diane; Viveiros, Miguel; Leandro, Clara; Arroz, Maria Jorge; Amaral, Leonard
The effect of thioridazine (TZ) was studied on the killing activity of human peripheral blood monocyte derived macrophages (HPBMDM) and of human macrophage cell line THP-1 at extracellular concentrations below those achievable clinically. These macrophages have nominal killing activity against bacteria and therefore, would not influence any activity that the compounds may have against intracellular localised Staphylococcus aureus. The results indicated that whereas TZ has an in vitro minimum inhibitory concentration (MIC) against the strains of S. aureus of 18, 0.1 mg/l of TZ in the medium completely inhibits the growth of S. aureus that has been phagocytosed by macrophages. The latter concentration was non-toxic to macrophages, did not cause cellular expression of activation marker CD69 nor induction of CD3+ T cell production of IFN-gamma, but blocked cellular proliferation and down-regulated the production of T cell-derived cytokines (IFN-gamma, IL-5). These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus. PMID:12127709
Sixty Minutes of Physical Activity per Day Included within Preschool Academic Lessons Improves Early Literacy
Kirk, Stacie M.; Kirk, Erik P.
Background: The effects of increases in physical activity (PA) on early literacy skills in preschool children are not known. Methods: Fifty-four African-American preschool children from a low socioeconomic urban Head Start participated over 8 months. A 2-group, quasi-experimental design was used with one preschool site participating in the PA…
... AGRICULTURE ALMONDS GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.441 Credit for market... each activity shall be to promote the sale, consumption or use of California almonds, and nothing... in California almond growing counties with more than 1,000 bearing acres: Provided, That...
Mian, Rubina; Shelton-Rayner, Graham; Harkin, Brendan; Williams, Paul
The aim of this study was to assess the effect of watching a psychological stressful event on the activation of leukocytes in healthy human volunteers. Blood samples were obtained from 32 healthy male and female subjects aged between 20 and 26 years before, during and after either watching an 83-minute horror film that none of the subjects had previously seen (The Texas Chainsaw Massacre, 1974) or by sitting quietly in a room (control group). Total differential cell counts, leukocyte activation as measured by the nitroblue tetrazolium (NBT) test, heart rate and blood pressure (BP) measurements were taken at defined time points. There were significant increases in peripheral circulating leukocytes, the number of activated circulating leukocytes, haemoglobin (Hb) concentration and haematocrit (Hct) in response to the stressor. These were accompanied by significant increases in heart rate, systolic and diastolic BP (P<0.05 from baseline). This is the first reported study on the effects of observing a psychologically stressful, albeit fictitious event on circulating leukocyte numbers and the state of leukocyte activation as determined by the nitrotetrazolium test. PMID:12637206
Backyards and Butterflies: Ways to Include Children with Disabilities in Outdoor Activities.
Greenstein, Doreen; And Others
This sourcebook is designed for children, parents, and families, detailing ideas for outdoor play and learning activities, with emphasis on involving children with disabilities in outdoor play. A rural perspective permeates the guide, although each chapter contains ideas for making outdoor environments more accessible and safer for all children,…
Physical Activity Programs in Higher Education: Modifying Net/Wall Games to Include Individuals with Disabilities
Braga, Luciana; Tracy, Julia F.; Taliaferro, Andrea R.
The growing number of students with disabilities in higher education settings has presented challenges for instructors with regards to appropriate inclusion. Concerning physical activity courses in higher education, instructors may not have the knowledge or resources to make modifications and accommodations that will ultimately result in…
Previous experiments from our laboratories have identified peptides derived from the human astrovirus coat protein (CP) that bind C1q and mannose binding lectin (MBL) inhibiting activation of the classical and lectin pathways of complement, respectively. The purpose of this study was to evaluate the function of these coat protein peptides (CPPs) in an in vitro model of complement-mediated disease (ABO incompatibility), preliminarily assess their in vivo complement suppression profile and develop more highly potent derivatives of these molecules. E23A, a 30 amino acid CPP derivative previously demonstrated to inhibit classical pathway activation was able to dose-dependently inhibit lysis of AB erythrocytes treated with mismatched human O serum. Additionally, when injected into rats, E23A inhibited the animals’ serum from lysing antibody-sensitized erythrocytes, providing preliminary in vivo functional evidence that this CPP can cross the species barrier to inhibit serum complement activity in rodents. A rational drug design approach was implemented to identify more potent CPP derivatives, resulting in the identification and characterization of a 15 residue peptide (Polar Assortant (PA)), which demonstrated both superior inhibition of classical complement pathway activation and robust binding to C1q collagen-like tails. PA also inhibited ABO incompatibility in vitro and demonstrated in vivo complement suppression up to 24 hours post-injection. CPP’s ability to inhibit ABO incompatibility in vitro, proof of concept in vivo inhibitory activity in rats and the development of the highly potent PA derivative set the stage for preclinical testing of this molecule in small animal models of complement-mediated disease. PMID:22906481
Space Resources for Teachers: Biology, Including Suggestions for Classroom Activities and Laboratory Experiments.
Lee, Tom E.; And Others
This compilation of resource units concerns the latest developments in space biology. Some of the topics included are oxygen consumption, temperature, radiation, rhythms, weightlessness, acceleration and vibration stress, toxicity, and sensory and perceptual problems. Many of the topics are interdisciplinary and relate biology, physiology,…
Jones, Ronald N; Critchley, Ian A; Whittington, William L H; Janjic, Nebojsa; Pottumarthy, Sudha
We evaluated the anti-gonococcal potency of faropenem along with 7 comparator reference antimicrobials against a preselected collection of clinical isolates. The 265 isolates were inclusive of 2 subsets: 1) 76 well-characterized resistant phenotypes of gonococcal strains (53 quinolone-resistant strains--31 with documented quinolone resistance-determining region changes from Japan, 15 strains resistant to penicillin and tetracycline, and 8 strains with intermediate susceptibility to penicillin) and 2) 189 recent isolates from clinical specimens in 2004 from 6 states across the United States where quinolone resistance is prevalent. Activity of faropenem was adversely affected by l-cysteine hydrochloride in IsoVitaleX (4-fold increase in [minimal inhibitory concentration] MIC50; 0.06 versus 0.25 microg/mL). The rank order of potency of the antimicrobials for the entire collection was ceftriaxone (MIC90, 0.06 microg/mL) > faropenem (0.25 microg/mL) > azithromycin (0.5 microg/mL) > cefuroxime (1 microg/mL) > tetracycline (2 microg/mL) > penicillin = ciprofloxacin = levofloxacin (4 microg/mL). Using MIC90 for comparison, faropenem was 4-fold more potent than cefuroxime (0.25 versus 1 microg/mL), but was 4-fold less active than ceftriaxone (0.25 versus 0.06 microg/mL). Although the activity of faropenem was not affected by either penicillinase production (MIC90, 0.12 microg/mL, penicillinase-positive) or increasing ciprofloxacin MIC (0.25 microg/mL, ciprofloxacin-resistant), increasing penicillin MIC was associated with an increase in MIC90 values (0.016 microg/mL for penicillin-susceptible to 0.25 microg/mL for penicillin-resistant strains). Among the recent (2004) clinical gonococcal isolates tested, reduced susceptibility to penicillins, tetracycline, and fluoroquinolones was high (28.0-94.2%). Geographic distribution of the endemic resistance rates of gonococci varied considerably, with 16.7-66.7% of the gonococcal isolates being ciprofloxacin-resistant in Oregon
Meijer, Harold J. G.; Hassen, Hussen Harrun; Govers, Francine
In eukaryotes phospholipase D (PLD) is involved in many cellular processes. Currently little is known about PLDs in oomycetes. Here we report that the oomycete plant pathogen Phytophthora infestans has a large repertoire of PLDs divided over six subfamilies: PXPH-PLD, PXTM-PLD, TM-PLD, PLD-likes, and type A and B sPLD-likes. Since the latter have signal peptides we developed a method using metabolically labelled phospholipids to monitor if P. infestans secretes PLD. In extracellular medium of ten P. infestans strains PLD activity was detected as demonstrated by the production of phosphatidic acid and the PLD specific marker phosphatidylalcohol. PMID:21423760
Evaluation of school-based dental health activities including fluoride mouth-rinsing in Hiraizumi, Japan.
Ohara, S; Kawaguchi, Y; Shinada, K; Sasaki, Y
School-based dental health activities conducted in Hiraizumi over the past 20 years have remarkably improved the dental health status of schoolchildren. For example, DMFT index of 12-year-old children decreased to 1.5 in 1998, one-half that of the national average. School dental health activities, which were focused on dental health education, resulted in an increase of filled teeth rates, a decrease in the number of missing teeth, and a decline in incisor caries (1979-1986). In addition, the introduction of a school-based fluoride mouth-rinsing program (1986 - ) showed a positive effect on the prevention of dental caries; a significant decrease was observed in the overall prevalence of dental caries, particularly in the molars. In Japan it seems advantageous to promote the dental health of schoolchildren by school-based programs that combine dental health examination, dental health education and fluoride mouth-rinsing program. Especially, to prevent dental caries in the mandibular first molars more effectively, it is recommended to start fluoride mouth-rinsing at age 5. PMID:12160185
Activation calculations for trapped protons below 200 MeV: Appendix
Laird, C. E.
Tables are given displaying of the results of the activation calculations of metal samples and other material aboard the Long Duration Exposure Facility-1 (LDEF-1) and Spacelab-2 with the computer program, PTRAP4. The computer printouts give the reaction, the reactant product, the proton reaction cross sections as a function of the energy of the incident protons, and the activation as a function of distance into the sample from the exposed surface.
Steady-state analysis of activated sludge processes with a settler model including sludge compression.
Diehl, S; Zambrano, J; Carlsson, B
A reduced model of a completely stirred-tank bioreactor coupled to a settling tank with recycle is analyzed in its steady states. In the reactor, the concentrations of one dominant particulate biomass and one soluble substrate component are modelled. While the biomass decay rate is assumed to be constant, growth kinetics can depend on both substrate and biomass concentrations, and optionally model substrate inhibition. Compressive and hindered settling phenomena are included using the Bürger-Diehl settler model, which consists of a partial differential equation. Steady-state solutions of this partial differential equation are obtained from an ordinary differential equation, making steady-state analysis of the entire plant difficult. A key result showing that the ordinary differential equation can be replaced with an approximate algebraic equation simplifies model analysis. This algebraic equation takes the location of the sludge-blanket during normal operation into account, allowing for the limiting flux capacity caused by compressive settling to easily be included in the steady-state mass balance equations for the entire plant system. This novel approach grants the possibility of more realistic solutions than other previously published reduced models, comprised of yet simpler settler assumptions. The steady-state concentrations, solids residence time, and the wastage flow ratio are functions of the recycle ratio. Solutions are shown for various growth kinetics; with different values of biomass decay rate, influent volumetric flow, and substrate concentration. PMID:26476681
Quasielastic neutron scattering experiments including activation energies and mathematical modeling of methyl halide dynamics
Kirstein, O.; Prager, M.; Grimm, H.; Buchsteiner, A.; Wischnewski, A.
Quasielastic neutron scattering experiments were carried out using the multichopper time-of-flight spectrometer V3 at the Hahn-Meitner Institut, Germany and the backscattering spectrometer at Forschungszentrum Jülich, Germany. Activation energies for CH3X, X =F, Cl, Br, and I, were obtained. In combination with results from previous inelastic neutron scattering experiments the data were taken to describe the dynamics of the halides in terms of two different models, the single particle model and the coupling model. Coupled motions of methyl groups seem to explain the dynamics of the methyl fluoride and chloride; however, the coupling vanishes with the increase of the mass of the halide atom in CH3Br and CH3I.
LIPID PEROXIDATION GENERATES BIOLOGICALLY ACTIVE PHOSPHOLIPIDS INCLUDING OXIDATIVELY N-MODIFIED PHOSPHOLIPIDS
Peroxidation of membranes and lipoproteins converts “inert” phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease. PMID:24704586
..., 44 FR 56673; 3 CFR, 1979 Comp., p. 435) ... relationships between host country, USAID and contractor staff to include host country leadership, flexible implementation authority, and effective management by the contractor; (v) Improved joint project...
Sahonero-Canavesi, Diana X; Sohlenkamp, Christian; Sandoval-Calderón, Mario; Lamsa, Anne; Pogliano, Kit; López-Lara, Isabel M; Geiger, Otto
Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth. PMID:25711932
Ozone control of biological activity during Earth's history, including the KT catastrophe
There have been brief periods since the beginning of the Cambrian some 600 m.y. ago when mass extinctions destroyed a significant fraction of living species. The most widely studied of these events is the catastrophe at the KT boundary that ended the long dominance of the dinosaurs. In addition to mass extinctions, there is another profound discontinuity in the history of Earth's biota, the explosion of life at the end of the Precambrian era which is an episode that is not explained well at all. For some 3 b.y. before the Cambrian, life had been present on Earth, but maintained a low level of activity which is an aspect of the biota that is puzzling, especially during the last two-thirds of that period. During the last 2 b.y. before the Cambrian, conditions at the Earth's surface were suitable for a burgeoning of the biota, according to most criteria: the oceans neither boiled nor were fozen solid during this time, and the atmosphere contained sufficient O for the development of animals. The purpose of this paper is to suggest that mass extinctions and the lackluster behavior of the Precambrian biota share a common cause: an inadequate amount of ozone in the atmosphere.
Design of a high-lift experiment in water including active flow control
Beutel, T.; Sattler, S.; El Sayed, Y.; Schwerter, M.; Zander, M.; Büttgenbach, S.; Leester-Schädel, M.; Radespiel, R.; Sinapius, M.; Wierach, P.
This paper describes the structural design of an active flow-control experiment. The aim of the experiment is to investigate the increase in efficiency of an internally blown Coanda flap using unsteady blowing. The system uses tailor-made microelectromechanical (MEMS) pressure sensors to determine the state of the oncoming flow and an actuated lip to regulate the mass flow and velocity of a stream near a wall over the internally blown flap. Sensors and actuators are integrated into a highly loaded system that is extremely compact. The sensors are connected to a bus system that feeds the data into a real-time control system. The piezoelectric actuators using the d 33 effect at a comparable low voltage of 120 V are integrated into a lip that controls the blowout slot height. The system is designed for closed-loop control that efficiently avoids flow separation on the Coanda flap. The setup is designed for water-tunnel experiments in order to reduce the free-stream velocity and the system’s control frequency by a factor of 10 compared with that in air. This paper outlines the function and verification of the system’s main components and their development.
RADIO PROPERTIES OF LOW-REDSHIFT BROAD-LINE ACTIVE GALACTIC NUCLEI INCLUDING EXTENDED RADIO SOURCES
Rafter, Stephen E.; Crenshaw, D. Michael; Wiita, Paul J.
We present a study of the extended radio emission in a sample of 8434 low-redshift (z < 0.35) broad-line active galactic nuclei (AGNs) from the Sloan Digital Sky Survey. To calculate the jet and lobe contributions to the total radio luminosity, we have taken the 846 radio core sources detected in our previous study of this sample and performed a systematic search in the FIRST database for extended radio emission that is likely associated with the optical counterparts. We found that 51 out of 846 radio core sources have extended emission (>4'' from the optical AGN) that is positively associated with the AGN, and we have identified an additional 12 AGNs with extended radio emission but no detectable radio core emission. Among these 63 AGNs, we found 6 giant radio galaxies, with projected emission exceeding 750 kpc in length, and several other AGNs with unusual radio morphologies also seen in higher redshift surveys. The optical spectra of many of the extended sources are similar to those of typical broad-line radio galaxy spectra, having broad H{alpha} emission lines with boxy profiles and large M{sub BH}. With extended emission taken into account, we find strong evidence for a bimodal distribution in the radio-loudness parameter R ({identical_to}{nu}{sub radio} L{sub radio}/{nu}{sub opt} L{sub opt}), where the lower radio luminosity core-only sources appear as a population separate from the extended sources, with a dividing line at log(R) {approx}1.75. This dividing line ensures that these are indeed the most radio-loud AGNs, which may have different or extreme physical conditions in their central engines when compared to the more numerous radio-quiet AGNs.
... 25 Indians 1 2014-04-01 2014-04-01 false Cost To Construct D Appendix D to Subpart C Indians... Indian Reservation Roads Program Funding Pt. 170, Subpt. C, App. D Appendix D to Subpart C—Cost To Construct Cost To Construct (Appendix D includes Tables 1-8 which BIA Division of Transportation...
... collaboration with eligible Title XII institutions and LDC counterparts for a problem-solving type activity to... much as a year or more. This stage recognizes the importance, for the problem-solving or ground..., 44 FR 56673; 3 CFR, 1979 Comp., p. 435)...
Fritsche, Thomas R; Strabala, Patty A; Sader, Helio S; Dowzicky, Michael J; Jones, Ronald N
Steadily increasing resistance among the Enterobacteriaceae to beta-lactams, fluoroquinolones, aminoglycosides, tetracyclines, and trimethoprim/sulfamethoxazole has compromised the utility of these commonly used antimicrobial classes for many community- or hospital-acquired infections. The development of tigecycline, the sentinel representative of a novel class of broad-spectrum agents (the glycylcyclines), represents an important milestone in addressing this critical need. Resistance to tigecycline might be expected to occur via the same mechanisms that produce tetracycline resistance; however, tigecycline remains stable and largely unaffected by the commonly occurring efflux and ribosomal protection resistance mechanisms. In this study, an international collection of Enterobacteriaceae (11327 isolates; 32.8% tetracycline-resistant) from global surveillance studies (2000-2004) were evaluated against tigecycline and other comparator antimicrobials. Although the most active agents were the carbapenems and aminoglycosides (97.5-99.7% susceptible), tigecycline displayed high potency (MIC50 and MIC90, 0.25 and 1 microg/mL) with 95.7% of all strains being inhibited at < or =2 microg/mL. Despite higher MIC values observed with Serratia spp. and Proteae, between 90.5% and 97.5% of isolates were inhibited by < or =4 microg/mL of tigecycline. Tetracycline-resistant populations demonstrated only modest decreases in potency to tigecycline, which appeared to be species-dependent (up to 2-fold only for Escherichia coli, Salmonella spp., Shigella spp., and Panteoa agglomerans; and up to 4-fold for Klebsiella spp., Enterobacter spp., and Citrobacter spp.). Among E. coli (263 isolates) and Klebsiella spp. (356) that meet recognized screening definitions for extended-spectrum beta-lactamase production, 100.0% and 94.4% were inhibited by tigecycline at 2 microg/mL, respectively. These findings confirm that tigecycline exhibits potency, breadth of spectrum, and stability to the
17 CFR Appendix A to Part 255 - Reporting and Recordkeeping Requirements for Covered Trading Activities
... positions: risk factors with respect to the related commodities set out in 17 CFR 20.2, the maturity of the... and Position Limits and Usage; • Risk Factor Sensitivities; • Value-at-Risk and Stress VaR... below, including “Risk Factor Sensitivities” and “Value-at-Risk and Stress Value-at-Risk,” relate to...
Should Physical Activity Be Included in Nutrition Education? A Comparison of Nutrition Outcomes with and without In-Class Activities
Palmer-Keenan, Debra M.; Corda, Kirsten
Limited-resource adults&apos; dietary intakes and nutrition behaviors improve as a result of Expanded Food and Nutrition Education Program (EFNEP)/Supplemental Nutrition Assistance Program Education (SNAP-Ed) participation; however, physical activity education is needed for improved health. The experimental study reported here assessed if spending…
29 CFR Appendix A to Part 32 - Appendix A to Part 32
... 29 Labor 1 2013-07-01 2013-07-01 false Appendix A to Part 32 A Appendix A to Part 32 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 32, App. A Appendix A to Part 32 Accommodations may take many forms based on the type of handicap and the...
Space shuttle/food system study. Volume 2, Appendix A: Active heating system-screening analysis. Appendix B: Reconstituted food heating techniques analysis
Technical data are presented which were used to evaluate active heating methods to be incorporated into the space shuttle food system design, and also to evaluate the relative merits and penalties associated with various approaches to the heating of rehydrated food during space flight. Equipment heating candidates were subject to a preliminary screening performed by a selection rationale process which considered the following parameters; (1) gravitational effect; (2) safety; (3) operability; (4) system compatibility; (5) serviceability; (6) crew acceptability; (7) crew time; (8) development risk; and (9) operating cost. A hot air oven, electrically heated food tray, and microwave oven were selected for further consideration and analysis. Passive, semi-active, and active food preparation approaches were also studied in an effort to determine the optimum method for heating rehydrated food. Potential complexity, cost, vehicle impact penalties, and palatability were considered in the analysis. A summary of the study results is provided along with cost estimates for each of the potential sytems
Goldstein, Ellie J C; Citron, Diane M; Merriam, C Vreni; Tyrrell, Kerin L
More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC(90)s, ≤0.015 μg/ml); and more active than cefazolin (MIC(90), 0.5 μg/ml) doxycycline (MIC(90), 0.125 μg/ml), azithromycin (MIC(90), 0.5 μg/ml), ampicillin-sulbactam (MIC(90), 0.125 μg/ml), and SMX-TMP (MIC(90), 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC(90), 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193
Ceftaroline versus Isolates from Animal Bite Wounds: Comparative In Vitro Activities against 243 Isolates, Including 156 Pasteurella Species Isolates
Citron, Diane M.; Merriam, C. Vreni; Tyrrell, Kerin L.
More than 5 million Americans are bitten by animals, usually dogs, annually. Bite patients comprise ∼1% of all patients who visit emergency departments (300,000/year), and approximately 10,000 require hospitalization and intravenous antibiotics. Ceftaroline is the bioactive component of the prodrug ceftaroline fosamil, which is FDA approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs), including those containing methicillin-resistant Staphylococcus aureus (MRSA). There are no in vitro data about the activity of ceftaroline against Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica, other Pasteurella spp., or other bite wound isolates. We therefore studied the in vitro activity of ceftaroline against 243 animal bite isolates. MICs were determined using the broth microdilution method according to CLSI guidelines. Comparator drugs included cefazolin, ceftriaxone, ertapenem, ampicillin-sulbactam, azithromycin, doxycycline, and sulfamethoxazole-trimethoprim (SMX-TMP). Ceftaroline was the most active agent against all 5 Pasteurella species, including P. multocida subsp. multocida and P. multocida subsp. septica, with a maximum MIC of ≤0.008 μg/ml; more active than ceftriaxone and ertapenem (MIC90s, ≤0.015 μg/ml); and more active than cefazolin (MIC90, 0.5 μg/ml) doxycycline (MIC90, 0.125 μg/ml), azithromycin (MIC90, 0.5 μg/ml), ampicillin-sulbactam (MIC90, 0.125 μg/ml), and SMX-TMP (MIC90, 0.125 μg/ml). Ceftaroline was also very active against all S. aureus isolates (MIC90, 0.125 μg/ml) and other Staphylococcus and Streptococcus species, with a maximum MIC of 0.125 μg/ml against all bite isolates tested. Ceftaroline has potential clinical utility against infections involving P. multocida, other Pasteurella species, and aerobic Gram-positive isolates, including S. aureus. PMID:23027193
U.S. Geological Survey Scientific Activities in the Exploration of Antarctica: Introduction to Antarctica (Including USGS Field Personnel: 1946-59)
Tony K. Meunier Edited by Williams, Richard S., Jr.; Ferrigno, Jane G.
international) programs in biology, geology, geophysics, hydrology, and mapping. Therefore, the USGS was the obvious choice for these tasks, because it already had a professional staff of experienced mapmakers, scientists, and program managers with the foresight, dedication, and understanding of the need for accurate maps to support the science programs in Antarctica when asked to do so by the U.S. National Academy of Sciences. Public Laws 85-743 and 87-626, signed in August 1958, and in September 1962, respectively, authorized the Secretary, U.S. Department of the Interior, through the USGS, to support mapping and scientific work in Antarctica (Meunier, 1979 [2007], appendix A). Open-File Report 2006-1116 includes scanned facsimiles of postal cachets. It has become an international practice to create postal cachets to commemorate special events and projects in Antarctica. A cachet is defined as a seal or commemorative design printed or stamped on an envelope to mark a philatelic or special event. The inked impression illustrates to the scientist, historian, stamp collector, and general public the multidisciplinary science projects staffed by USGS and collaborating scientists during the field season. Since 1960, philatelic cachets have been created by team members for each USGS field season and, in most cases, these cachets depict the specific geographic areas and field season program objectives. The cachets become a convenient documentation of the people, projects, and geographic places of interest for that year. Because the cachets are representative of USGS activities, each year's cachet is included as a digital facsimile in that year's Open-File Report. In the 1980s, multiple USGS cachets were prepared each year, one for use by the winter team at Amundsen-Scott South Pole Station and the other for the project work areas of the austral summer field season programs.
Update of the BIPM comparison BIPM.RI(II)-K1.Sr-85 of activity measurements of the radionuclide 85Sr to include the 2009 result of the POLATOM (Poland)
Michotte, C.; Ratel, G.; Courte, S.; Dziel, T.; Listkowska, A.
Since 1975, ten laboratories have submitted 27 samples of known activity of 85Sr to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Sr-85. The values of the activity submitted were between about 0.2 MBq and 19 MBq. The key comparison reference value (KCRV) has been recalculated to include the primary standardization result for the POLATOM, Poland. There are now four results in the BIPM.RI(II)-K1.Sr-85 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the updated KCRV have been calculated and the results are given in the form of a table. A graphical presentation is also given. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Expenditures for Scientific Activities at Universities and Colleges, Fiscal Year 1975. Detailed Statistical Tables, Appendixes B and C.
Provided are detailed statistical tables for the fiscal year 1975 National Science Foundation (NSF) survey of expenditures for scientific activities at universities and colleges. The survey included 540 universities and colleges which account for more than 99% of all academic R&D expenditures. In addition to data reported for 1975, selected…
17 CFR Appendix B to Part 37 - Guidance on Compliance With Core Principles
... Core Principles B Appendix B to Part 37 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... or suspend, and/or terminate activities or access of a member, including members with trading... TRADING—The board of trade shall monitor trading in the contracts of the facility to ensure...
Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David
Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene. PMID:25534744
Modified agar dilution susceptibility testing method for determining in vitro activities of antifungal agents, including azole compounds.
Yoshida, T; Jono, K; Okonogi, K
In vitro activities of antifungal agents, including azole compounds, against yeasts were easily determined by using RPMI-1640 agar medium and by incubating the plates in the presence of 20% CO2. The end point of inhibition was clear by this method, even in the case of azole compounds, because of the almost complete inhibition of yeast growth at high concentrations which permitted weak growth of some Candida strains by traditional methods. MICs obtained by the agar dilution method were similar to those obtained by the broth dilution method proposed by the National Committee for Clinical Laboratory Standards. PMID:9174197
Increasing resource allocation and research into tobacco control activities: a comprehensive approach including primary prevention, treatment and brief intervention.
The range of tobacco control activities should be viewed as essential parts of a complex multi-component puzzle. Intervention strategies designed to address tobacco control should be comprehensive and include both primary and secondary prevention activities and be multi-faceted and capable of bringing about change at both the individual and broader social and cultural levels. In this paper I argue for a mutually inclusive framework in which the various components contribute in important and different ways. I examine the prevalence of smoking and identify the high risk groups, then I examine the range of available strategies and present the evidence for their success. I discuss the primary prevention approaches such as warning labels, taxes, price increases, workplace bans, education in schools, mass media and self-help materials, as well as brief interventions and treatment strategies which are conducted at the worksite, general practice and specialized cessation clinics. The areas for future research are delineated for increased resource allocation and include: the best ways to disseminate brief interventions to smokers, methods to motivate smokers; training of health professionals to deliver brief interventions; enhancing quitting and access to existing treatment resources among specific disadvantaged minority groups, e.g. migrants, unemployed youth, the effect on smoking prevalence of warning labels on cigarette packets and price rises on cigarettes. PMID:16818330
Chalasani, Ajay G.; Dhanarajan, Gunaseelan; Nema, Sushma; Sen, Ramkrishna; Roy, Utpal
In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule. PMID:26696963
Van Zandt, Noah R.; McCrae, Jack E.; Fiorino, Steven T.
Aimpoint acquisition and maintenance is critical to high energy laser (HEL) system performance. This study demonstrates the development by the AFIT/CDE of a physics-based modeling package, PITBUL, for tracking airborne targets for HEL applications, including atmospheric and sensor effects and active illumination, which is a focus of this work. High-resolution simulated imagery of the 3D airborne target in-flight as seen from the laser position is generated using the HELSEEM model, and includes solar illumination, laser illumination, and thermal emission. Both CW and pulsed laser illumination are modeled, including the effects of illuminator scintillation, atmospheric backscatter, and speckle, which are treated at a first-principles level. Realistic vertical profiles of molecular and aerosol absorption and scattering, as well as optical turbulence, are generated using AFIT/CDE's Laser Environmental Effects Definition and Reference (LEEDR) model. The spatially and temporally varying effects of turbulence are calculated and applied via a fast-running wave optical method known as light tunneling. Sensor effects, for example blur, sampling, read-out noise, and random photon arrival, are applied to the imagery. Track algorithms, including centroid and Fitts correlation, as a part of a closed loop tracker are applied to the degraded imagery and scored, to provide an estimate of overall system performance. To gauge performance of a laser system against a UAV target, tracking results are presented as a function of signal to noise ratio. Additionally, validation efforts to date involving comparisons between simulated and experimental tracking of UAVs are presented.
Farrell, David J; Sader, Helio S; Castanheira, Mariana; Biedenbach, Douglas J; Rhomberg, Paul R; Jones, Ronald N
CEM-101 is a novel fluorinated macrolide-ketolide with potent activity against bacterial pathogens that are susceptible or resistant to other macrolide-lincosamide-streptogramin B (MLS(B))-ketolide agents. CEM-101 is being developed for oral and parenteral use in moderate to moderately severe community-acquired bacterial pneumonia. The objective of this study was to assess the activity of CEM-101 and comparators against contemporary respiratory tract infection (RTI) isolates. A worldwide sample of organisms was used, including Streptococcus pneumoniae [n=168; 59.3% erythromycin-resistant and 18 multidrug-resistant (MDR) serogroup 19A strains], Moraxella catarrhalis (n=21; 11 beta-lactamase positive), Haemophilus influenzae (n=100; 48 beta-lactamase positive), Haemophilus parainfluenzae and Haemophilus haemolyticus (n=12), and Legionella pneumophila (n=30). Testing and interpretation were performed using reference Clinical and Laboratory Standards Institute methods. CEM-101 was very potent against S. pneumoniae [minimum inhibitory concentration for 90% of the organisms (MIC90)=0.25 mg/L; highest MIC at 0.5 mg/L] and was 2- and > or =32-fold more active than telithromycin and clindamycin, respectively. CEM-101 also demonstrated potent activity against S. pneumoniae MDR-19A strains (MIC90=0.5 mg/L). CEM-101 was the most potent antimicrobial agent tested against L. pneumophila, with all MIC values at < or = 0.015 mg/L (telithromycin MIC90=0.03 mg/L). CEM-101 was as potent as azithromycin against Haemophilus spp. RTI pathogens (MIC90=2 mg/L), with no variations for beta-lactamase production. CEM-101 MIC values against M. catarrhalis were all at < or =0.5mg/L. Interestingly, CEM-101 potency was ca. 6 log(2) dilutions greater than telithromycin MIC results among 44 beta-haemolytic streptococci having telithromycin MICs > or = 2 mg/L. CEM-101 exhibited the greatest potency and widest spectrum of activity against RTI pathogens among the tested MLS(B)-ketolide agents
Development and flight evaluation of active controls in the L-1011. [including wing load alleviation and stability augmentation
Johnston, J. F.; Urie, D. M.
Active controls in the Lockheed L-1011 for increased energy efficiency are discussed. Active wing load alleviation for extended span, increased aspect ratio, and active stability augmentation with a smaller tail for reduced drag and weight are among the topics considered. Flight tests of active wing load alleviation on the baseline aircraft and moving-base piloted simulation developing criteria for stability augmentation are described.
EGFR activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity
Pfäffle, Heike N.; Wang, Meng; Gheorghiu, Liliana; Ferraiolo, Natalie; Greninger, Patricia; Borgmann, Kerstin; Settleman, Jeffrey; Benes, Cyril H.; Sequist, Lecia V.; Zou, Lee; Willers, Henning
In lung cancer patients whose tumors harbor activating mutations in the epidermal growth factor receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared to wild-type cancers. However, the mechanisms underlying this association have remained elusive. Here, we describe a cellular phenotype of crosslinker sensitivity in a subset of EGFR-mutant lung cancer cell lines that is reminiscent of the defects seen in cells impaired in the Fanconi Anemia pathway, including a pronounced G2/M cell-cycle arrest and chromosomal radial formation. We identified a defect downstream of FANCD2 at the level of recruitment of FAN1 nuclease and DNA interstrand crosslink (ICL) unhooking. The effect of EGFR mutation was epistatic with FANCD2. Consistent with the known role of FANCD2 in promoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhibited an impaired RAD51 foci response to ICLs, but not to DNA double-strand breaks. EGFR kinase inhibition affected RAD51 foci formation neither in EGFR mutant nor wild-type cells. In contrast, EGFR depletion or overexpression of mutant EGFR in wild-type cells suppressed RAD51 foci, suggesting an EGFR kinase-independent regulation of DNA repair. Interestingly, EGFR-mutant cells treated with the PARP inhibitor olaparib also displayed decreased FAN1 foci induction, coupled with a putative block in a late HRR step. As a result, EGFR-mutant lung cancer cells exhibited olaparib sensitivity in-vitro and in-vivo. Our findings provide insight into the mechanisms of cisplatin and PARP inhibitor sensitivity of EGFR-mutant cells, yielding potential therapeutic opportunities for further treatment individualization in this genetically defined subset of lung cancer. PMID:23966292
... 32 National Defense 1 2014-07-01 2014-07-01 false DD Form 215 C Appendix C to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to Part 45—DD Form 215 EC21OC91.050...
... 32 National Defense 1 2012-07-01 2012-07-01 false DD Form 215 C Appendix C to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to Part 45—DD Form 215 EC21OC91.050...
2 CFR Appendix A to Part 230 - General Principles
... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...
32 CFR Appendix A to Part 881 - Glossary of Terms
... 32 National Defense 6 2014-07-01 2014-07-01 false Glossary of Terms A Appendix A to Part 881 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY PERSONNEL... Appendix A to Part 881—Glossary of Terms Active Military Service—See 38 U.S.C. 106. Civilian or...
... 32 National Defense 6 2012-07-01 2012-07-01 false Glossary of Terms A Appendix A to Part 881 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY PERSONNEL... Appendix A to Part 881—Glossary of Terms Active Military Service—See 38 U.S.C. 106. Civilian or...
... 32 National Defense 6 2013-07-01 2013-07-01 false Glossary of Terms A Appendix A to Part 881 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE MILITARY PERSONNEL... Appendix A to Part 881—Glossary of Terms Active Military Service—See 38 U.S.C. 106. Civilian or...
34 CFR Appendix B to Part 300 - Proportionate Share Calculation
... 34 Education 2 2010-07-01 2010-07-01 false Proportionate Share Calculation B Appendix B to Part... CHILDREN WITH DISABILITIES Pt. 300, App. B Appendix B to Part 300—Proportionate Share Calculation Each LEA... early intervening activities in § 300.226). The following outlines the calculations for the example...
... 32 National Defense 1 2013-07-01 2013-07-01 false DD Form 215 C Appendix C to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to...
... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 215 C Appendix C to Part 45 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to...
... income (i.e., gross income earned from federally-supported activities) see § 215.24 of 2 CFR part 215... but the allocability of costs provisions of Appendix A, subsection C.e. of 2 CFR part 225 (OMB Circular A-87); Appendix A, Section C.4. of 2 CFR part 220 (OMB Circular A-21); Section A.4. of...
Rhomberg, Paul R.; Kaplan, Nachum; Jones, Ronald N.; Farrell, David J.
Staphylococcus aureus and coagulase-negative staphylococci (CoNS) are responsible for a wide variety of human infections. The investigational antibacterial Debio1450 (previously AFN-1720), a prodrug of Debio1452 (previously AFN-1252), specifically targets staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. The activity of Debio1452 against CoNS, methicillin-susceptible S. aureus (MSSA), and methicillin-resistant S. aureus (MRSA), including significant clones, was determined. A globally diverse collection of 574 patient isolates from 35 countries was tested that included CoNS (6 species, 103 strains), MSSA (154 strains), MRSA (163 strains), and molecularly characterized strains (including spa-typed MRSA clones; 154 strains). The isolates were tested for susceptibility by CLSI broth microdilution methods against Debio1452 and 10 comparators. The susceptibility rates for the comparators were determined using CLSI and EUCAST breakpoint criteria. All S. aureus and CoNS strains were inhibited by Debio1452 concentrations of ≤0.12 and ≤0.5 μg/ml, respectively. The MIC50s for MSSA, MRSA, and molecularly characterized MRSA strains were 0.004 μg/ml, and the MIC90s ranged from 0.008 to 0.03 μg/ml. The MICs were higher for the CoNS isolates (MIC50/90, 0.015/0.12 μg/ml). Among S. aureus strains, resistance was common for erythromycin (61.6%), levofloxacin (49.0%), clindamycin (27.6%), tetracycline (15.7%), and trimethoprim-sulfamethoxazole (7.0%). Debio1452 demonstrated potent activity against MSSA, MRSA, and CoNS. Debio1452 showed significantly greater activity overall (MIC50, 0.004 μg/ml) than the other agents tested against these staphylococcal species, which included dominant MRSA clones and strains resistant to currently utilized antimicrobial agents. PMID:25691627
17 CFR Appendix B to Part 160 - Sample Clauses
... FINANCIAL INFORMATION UNDER TITLE V OF THE GRAMM-LEACH-BLILEY ACT Pt. 160, App. B Appendix B to Part 160—Sample Clauses This appendix only applies to privacy notices provided before January 1, 2011. Financial institutions, including a group of financial holding company affiliates that use a common privacy notice,...
... FINANCIAL INFORMATION Pt. 160, App. B Appendix B to Part 160—Sample Clauses This appendix only applies to privacy notices provided before January 1, 2011. Financial institutions, including a group of financial... parties: • Financial service providers, such as ; • Non-financial companies, such as ; and • Others,...
... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Executive Order 13570 C Appendix C to... Appendix C to Part 510—Executive Order 13570 Executive Order 13570 of April 18, 2011 Prohibiting Certain... laws of the United States of America, including the International Emergency Economic Powers Act (50...
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Executive Order 13661 B Appendix B to... Appendix B to Part 589—Executive Order 13661 Executive Order 13661 of March 16, 2014 Blocking Property of... Constitution and the laws of the United States of America, including the International Emergency...
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Executive Order 13570 C Appendix C to... Appendix C to Part 510—Executive Order 13570 Executive Order 13570 of April 18, 2011 Prohibiting Certain... laws of the United States of America, including the International Emergency Economic Powers Act (50...
31 CFR Appendix A to Part 589 - Executive Order 13660
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Executive Order 13660 A Appendix A to... Appendix A to Part 589—Executive Order 13660 Executive Order 13660 of March 6, 2014 Blocking Property of... Constitution and the laws of the United States of America, including the International Emergency...
... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Executive Order 13570 C Appendix C to... Appendix C to Part 510—Executive Order 13570 Executive Order 13570 of April 18, 2011 Prohibiting Certain... laws of the United States of America, including the International Emergency Economic Powers Act (50...
31 CFR Appendix C to Part 589 - Executive Order 13662
... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Executive Order 13662 C Appendix C to... Appendix C to Part 589—Executive Order 13662 Executive Order 13662 of March 20, 2014 Blocking Property of... Constitution and the laws of the United States of America, including the International Emergency...
... 32 National Defense 2 2013-07-01 2013-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...
... 32 National Defense 2 2014-07-01 2014-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...
... 32 National Defense 2 2012-07-01 2012-07-01 false Audit Working Papers D Appendix D to Part 290.... 290, App. D Appendix D to Part 290—Audit Working Papers (a) Definition (1) Audit working papers... interviews and inquiries, and other available sources. Audit working papers may also include contract...
Agrati, Chiara; Castilletti, Concetta; Cimini, Eleonora; Romanelli, Antonella; Lapa, Daniele; Quartu, Serena; Martini, Federico; Capobianchi, Maria Rosaria
West Nile virus (WNV) causes a severe central nervous system infection in humans, primarily in the elderly and immunocompromised subjects. Human γδ T-cells play a critical role in the immune response against viruses, and studies of WNV meningoencephalitis in laboratory mice described a role of γδ T-cells in the protective immune response. Aim of this study was to analyze the cytolytic and non-cytolytic antiviral activity of human Vδ2 T-cells against WNV replication. The anti-WNV activity of soluble factor released by zoledronic acid (ZA)-activated Vδ2 T-cell lines and the cytotoxic capability of Vδ2 T-cell lines against WNV-infected cells were tested in vitro. The activation of Vδ2 T-cell lines was able to inhibit WNV replication through the release of soluble factors. IFN-γ is massively released by activated Vδ2 T-cell lines and is involved in the anti-WNV activity. Moreover, the Vδ2 T-cell lines can efficiently kill WNV-infected cells possibly through perforin-mediated mechanism. Altogether, our results provide insight into the effector functions of human Vδ2 T-cells against WNV. The possibility to target these cells by ZA, a commercially available drug used in humans, could potentially offer a new immunotherapeutic strategy for WNV infection. PMID:27196553
Coulson, Judy M; Edgson, Jodie L; Marshall-Jones, Zoe V; Mulgrew, Robert; Quinn, John P; Woll, Penella J
We have described previously a complex E-box enhancer (-147) of the vasopressin promoter in small-cell lung cancer (SCLC) extracts [Coulson, Fiskerstrand, Woll and Quinn, (1999) Biochem. J. 344, 961-970]. Upstream stimulatory factor (USF) heterodimers were one of the complexes binding to this site in vitro. We now report that USF overexpression in non-SCLC (NSCLC) cells can functionally activate vasopressin promoter-driven reporters that are otherwise inactive in this type of lung cancer cell. Site-directed mutagenesis and electrophoretic mobility-shift analysis demonstrate that although the -147 E-box contributes, none of the previously predicted E-boxes (-147, -135, -34) wholly account for this USF-mediated activation in NSCLC. 5' Deletion showed the key promoter region as -52 to +42; however, USF-2 binding was not reliant on the -34 E-box, but on a novel adjacent CACGGG non-canonical E-box at -42 (motif E). This mediated USF binding in both SCLC and USF-2-transfected NSCLC cells. Mutation of motif E or the non-canonical TATA box abolished activity, implying both are required for transcriptional initiation on overexpression of USF-2. Co-transfected dominant negative USF confirmed that binding was required through motif E for function, but that the classical activation domain of USF was not essential. USF-2 bound motif E with 10-fold lower affinity than the -147 E-box. In NSCLC, endogenous USF-2 expression is low, and this basal level appears to be insufficient to activate transcription of arginine vasopressin (AVP). In summary, we have demonstrated a novel mechanism for USF activation, which contributes to differential vasopressin expression in lung cancer. PMID:12403649
Northeastern Gulf of Mexico coastal and marine ecosystem program: Data search and synthesis, annotated bibliography. Appendix C: Geology. Final report
This study summarizes environmental and socioeconomic information related to the Florida Panhandle Outer Continental Shelf (OCS). It contains a conceptual model of active processes and identification of information gaps that will be useful in the design of future environmental studies in the geographic area. The annotated bibliography for this study is printer in six volumes, each pertaining to a specific topic. They are as follows: Appendix A--Physical Oceanography; Appendix B--Meteorology; Appendix C--Geology; Appendix D--Chemistry; Appendix E--Biology; and Appendix F--Socioeconomics. This volume contains bibliographic references pertaining to geology.
Northeastern Gulf of Mexico coastal and marine ecosystem program: Data search and synthesis, annotated bibliography. Appendix D: Chemistry. Final report
This study summarizes environmental and socioeconomic information related to the Florida Panhandle Outer Continental Shelf (OCS). It contains a conceptual model of active processes and identification of information gaps that will be useful in the design of future environmental studies in the geographic area. The annotated bibliography for this study is printer in six volumes, each pertaining to a specific topic. They are as follows: Appendix A--Physical Oceanography; Appendix B--Meteorology; Appendix C--Geology; Appendix D--Chemistry; Appendix E--Biology; and Appendix F--Socioeconomics. This volume contains bibliographic references pertaining to chemistry.
Northeastern Gulf of Mexico coastal and marine ecosystem program: Data search and synthesis, annotated bibliography. Appendix E: Biology. Final report
This study summarizes environmental and socioeconomic information related to the Florida Panhandle Outer Continental Shelf (OCS). It contains a conceptual model of active processes and identification of information gaps that will be useful in the design of future environmental studies in the geographic area. The annotated bibliography for this study is printer in six volumes, each pertaining to a specific topic. They are as follows: Appendix A--Physical Oceanography; Appendix B--Meteorology; Appendix C--Geology; Appendix D--Chemistry; Appendix E--Biology; and Appendix F--Socioeconomics. This volume contains bibliographic references pertaining to biology.
Han, Sang Duk; Sung, Hyun Jung; Lee, Ga Hyeon; Jun, Joon-Ho; Son, Miwon; Kang, Myung Joo
Chitosan-based film-forming gel is regarded as a promising vehicle for topical delivery of antimicrobial agents to skin wounds, since it protects from microbial infection and the cationic polymer itself possesses antibacterial activity. In this study, possible synergistic interaction against common skin pathogens between the cationic polymer and tyrothricin (TRC), a cyclic polypeptide antibiotic, was investigated, by determining the concentration to inhibit 90% of bacterial isolates (MIC). The addition of the polysaccharide to TRC dramatically reduced the MIC values of TRC by 1/33 and 1/4 against both methicillin-resistant and methicillinsusceptible Staphylococcus aureus, respectively. The synergism of TRC and chitosan combination against both strains was demonstrated by the checkerboard method, with a fractional inhibitory concentration index below 0.5. Moreover, co-treatment of TRC and chitosan exhibited antibacterial activity against Pseudomonas aeruginosa, due to the antibacterial activity of chitosan, whereas TRC itself did not inhibit the gram-negative bacterial growth. These findings suggested that the use of chitosan-based film for topical delivery of TRC could be an alternative to improve TRC antimicrobial activity against strains that are abundant in skin wounds. PMID:26907760
Nees, D W; Stein, P A; Ludwig, R A
From nucleotide sequencing analyses, the A. caulinodans nifA gene seems to be under dual control by the Ntr (in response to available N) and Fnr (in response to available O2) transcriptional activation/repression systems. Because it fixes N2 in two contexts, the Ntr system might regulate A. caulinodans nif gene expression ex planta, while the Fnr system might similarly regulate in planta. As nifA upstream-activating elements, we have identified: (i) a gpNifA binding site allowing autogenous nifA regulation, (ii) an Ntr-dependent transcription start, presumably the target of gpNifA activation, and (iii) an "anaerobox" tetradecameric nucleotide sequence that is precisely conserved among O2 regulated enteric bacterial genes controlled by the gpFnr transcriptional activator. Because it is precisely positioned upstream of enteric bacterial transcriptional starts, the "anaerobox" sequence may constitute the gpFnr DNA binding site. If so, then a second, Ntr-independent nifA transcription start may exist. We have also deduced the A. caulinodans nifA open reading frame and have compared the gene product (gpNifA) with those of other N2-fixing organisms. These proteins exhibit strongly conserved motifs: (i) sites conserved among ATP-binding proteins, (ii) an interdomain linker region, and (iii) a C-terminal alpha-helix-turn-alpha-helix DNA binding site. PMID:3186446
Iwasaki, Daichi; Hayashihara, Kayoko; Shima, Hiroki; Higashide, Mika; Terasawa, Masahiro; Gasser, Susan M; Shinohara, Miki
Because DNA double-strand breaks (DSBs) are one of the most cytotoxic DNA lesions and often cause genomic instability, precise repair of DSBs is vital for the maintenance of genomic stability. Xrs2/Nbs1 is a multi-functional regulatory subunit of the Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex, and its function is critical for the primary step of DSB repair, whether by homologous recombination (HR) or non-homologous end joining. In human NBS1, mutations result truncation of the N-terminus region, which contains a forkhead-associated (FHA) domain, cause Nijmegen breakage syndrome. Here we show that the Xrs2 FHA domain of budding yeast is required both to suppress the imprecise repair of DSBs and to promote the robust activation of Tel1 in the DNA damage response pathway. The role of the Xrs2 FHA domain in Tel1 activation was independent of the Tel1-binding activity of the Xrs2 C terminus, which mediates Tel1 recruitment to DSB ends. Both the Xrs2 FHA domain and Tel1 were required for the timely removal of the Ku complex from DSB ends, which correlates with a reduced frequency of imprecise end-joining. Thus, the Xrs2 FHA domain and Tel1 kinase work in a coordinated manner to maintain DSB repair fidelity. PMID:26990569
Age-related changes in trunk neuromuscular activation patterns during a controlled functional transfer task include amplitude and temporal synergies.
Quirk, D Adam; Hubley-Kozey, Cheryl L
While healthy aging is associated with physiological changes that can impair control of trunk motion, few studies examine how spinal muscle responses change with increasing age. This study examined whether older (over 65 years) compared to younger (20-45 years) adults had higher overall amplitude and altered temporal recruitment patterns of trunk musculature when performing a functional transfer task. Surface electromyograms from twelve bilateral trunk muscle (24) sites were analyzed using principal component analysis, extracting amplitude and temporal features (PCs) from electromyographic waveforms. Two PCs explained 96% of the waveform variance. Three factor ANOVA models tested main effects (group, muscle and reach) and interactions for PC scores. Significant (p<.0125) group interactions were found for all PC scores. Post hoc analysis revealed that relative to younger adults, older adults recruited higher agonist and antagonistic activity, demonstrated continuous activation levels in specific muscle sites despite changing external moments, and had altered temporal synergies within abdominal and back musculature. In summary both older and younger adults recruit highly organized activation patterns in response to changing external moments. Differences in temporal trunk musculature recruitment patterns suggest that older adults experience different dynamic spinal stiffness and loading compared to younger adults during a functional lifting task. PMID:25457424