Source: http://zapytania-ofertowe.umb.edu.pl/?q=preparation-and-implementation-training-service-consisting-execution-classes-kaunas-summer-school
Timestamp: 2020-07-13 21:48:55
Document Index: 163094027

Matched Legal Cases: ['art 1', 'art 2', 'art 3', 'art 4', 'art 5', 'art 6', 'art 7', 'art 8', 'art 9', 'art 10', 'art 11', 'art 1', 'art 2', 'art 3', 'art 4', 'art 5', 'art 6', 'art 7', 'art 8', 'art 9', 'art 10', 'art 11', 'arts 2', 'arts 1', 'art. 13', 'arts 1', 'arts 1']

Preparation and implementation of a training service consisting in the execution of classes at the Kaunas Summer School for doctoral students within the project: "Interdisciplinary, international doctoral studies..." | Zapytania ofertowe na wyłonienie Wykonawcy zamówienia
Preparation and implementation of a training service consisting in the execution of classes at the Kaunas Summer School for doctoral students within the project: "Interdisciplinary, international doctoral studies..."
2020-05-11 08:41 — dzial.wspołpracy
AWM/NCBR/07/2020/TM
for the selection of a Contractor for a procurement the subject matter of which are social services and other specific services listed in Annex XIV to Directive 2014/24/EU and Annex XVII to Directive 2014/25/EU (hereinafter referred to as social services) and whose value is less than the amounts specified in Article 138(1) of the Act of 29 January 2004. - Public procurement law.
1.	Type of order
2.	Subject matter of the procurement
1)	The procurement concerns the project entitled "Interdisciplinary, international doctoral studies in medical biology and pharmaceutical sciences at the Medical University of Bialystok” co-financed by the European Union as part of the Knowledge Education Development 2014-2020 Operational Programme.
2)	The subject matter of the order is to prepare and carry out a training service consisting in the execution of classes in English within the Kaunas Summer School entitled "Biotechnology in medicine and pharmacy" for 12 students of international doctoral studies in medical and pharmaceutical sciences. The summer school program will be prepared and co-organized by the Medical University of Bialystok, Vytautas Magnus University in Kaunas and Lithuanian University of Health Sciences.
3)	Information about the summer school in Kaunas:
In total, the summer school classes will last 5 days.
The planned number of hours of classes per day: 10 teaching hours on average. 1 teaching hour = 45 minutes. It will be possible to carry out some classes at the same time, for different groups.
The timetable for the execution of the summer school, specifying a particular day and time for the execution of the given classes will be agreed in cooperation between the Contracting Authority, the Vytautas Magnus University and Lithuanian University of Health Sciences no later than 30 days in advance before the beginning of the summer school execution. Therefore, after agreeing on the final schedule for the execution of the summer school, the deadlines for the execution of individual classes (specific day and time) will be established on a current basis between the Contracting Authority and the Contractor. Classes will be held every day not earlier than 8.00 local time and not later than 16.00 local time.
The function of the coordinator of the summer school in Kaunas will be performed by prof. dr hab. Audrius Maruška of Vytautas Magnus University. The administrative coordinator of the summer school will be appointed by Vytautas Magnus University.
The summer school framework includes:
- fundamental aspects of theory, practice and equipment used in quality control as well as in the evaluation of biotechnological products, processes and procedures, including fermentation and post-processing, using natural products, medicinal plants, including micro-cultural aspects, cellular aspects and the application of biophysical methods;
- discussing the use of biological systems, living organisms or elements thereof to obtain products with a therapeutic effect and diagnostic possibilities.
The Contracting Authority will provide the reagents and small consumable equipment necessary to carry out practical classes in the summer school. Reagents and small consumables will be delivered to the summer school site.
For the purpose of conducting classes, the Contracting Authority shall provide at least the following reagents and small consumable equipment:
- automatic pipettes;
- semi-micro UV trays;
- SPME fibres for micro-extraction;
- homogenizers;
- chromatographic vials for headspace;
- PTFE silicone septides for chromatographic vials;
- caps for chromatographic vials;
- chromatographic columns;
- chromatographic solvents;
4)	Topics of the classes
The subject matter of the procurement is to conduct the following classes:
Part 1 Application of ultraviolet filters technologies in cosmetics;
Part 2 Evaluation of nanoparticles toxicity at different biological organization levels: cells, organelles and biopolymers;
Part 3 Development of topical pharmaceutical products, penetration tests and other analytical procedures;
Part 4 Preparation technologies of natural raw materials;
Part 5 Influence of innovative technologies on preparation and quality of medicinal and aromatic plants raw material;
Part 6 Technologies for the evaluation of biological environmental factors;
Part 7 Processes and apparatus in biopharmaceutical industry;
Part 8 Drug and gene delivery into cells using cell electroporation;
Part 9 Rules of instrumentation designing, methodology of 3D printing for biotechnology, analytical procedures and data extraction;
Part 10 Basics of fermentation and purification of metabolites;
Part 11 Miniaturization of analytical tools and application for qualitative and quantitative analysis of biomolecules.
All the classes (50 teaching hours) within the summer school will be practical. Whereas 44 hours of classes within the total number of classes will be laboratory classes.
A contractor may submit a tender for one or more parts of the procurement.
The framework for each class is set out in an annex to the detailed description of the subject matter of the procurement.
5)	The purpose of the classes
The aim of the classes will be to acquaint the participants of the summer school, among others:
- with analytical equipment used in the biotechnological process (capillary electrophoresis, colorimetry);
- with manners of preparing samples for analysis;
- with 3D printing methodology for biotechnology and penetration testing;
- with analytical procedures and data analysis and extraction;
- with the principles of instrumentation design, operation and optimum choice of apparatus;
- with aspects of analytical testing used in biotechnology;
- with multidimensional data analysis, filtration and output noise, data handling.
6)	Form of the execution of classes
All the classes will be conducted in a closed formula - only with the participation of the Contracting Authority's doctoral students, prepared according to the specific needs reported by the doctoral students. The Contractor of each subject will verify the needs of the participants in terms of the detailed subject matter of the workshop before the summer school begins by sending a short questionnaire to the Contracting Authority at least 30 days in advance. The Contractor of each topic will present the programme for the approval of the Contracting Authority.
7)	Target group:
Participants of the summer school are 12 students of international doctoral studies in the field of medical and pharmaceutical sciences, pursuing a doctoral dissertation or remaining in the period before commencing the pursuit of a doctoral dissertation. All participants know English very well. In the case of three subjects, the classes will be conducted for one group of 12 PhD students. In the case of eight subjects, the classes will be conducted in groups of 6, two groups for each of these subjects.
8)	Planned date and place of the execution of the service:
All summer school activities in Kaunas will be carried out in the period between 22-26 September 2020. Classes will be conducted at Vytautas Magnus University in Kaunas. The Contracting Authority will make arrangements with Vytautas Magnus University to provide training rooms, laboratories and necessary equipment.
Place of the execution of the service: the seat of Vytautas Magnus University, K. Donelaičio g. 58, LT-44248 Kaunas, Lithuania, laboratory or lecture hall equipped with a multimedia projector, flipchart board, flipchart sheets and coloured markers. The exact location (lecture hall) will be notified to the Contractor before the summer school begins.
ATTENTION: The Contracting Authority shall not cover the cost of travel to the summer school, accommodation or meals.
9)	The total number of hours of teaching classes in the summer school: 50. Within this number, 44 hours of laboratory classes are foreseen. The remaining 6 hours of teaching will not be laboratory classes.
The number of teaching hours of classes, including the determination whether they are laboratory classes or not, is as follows:
Part 1- Application of ultraviolet filters technologies in cosmetics: 2 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 4 teaching hours total (laboratory classes: YES);
Part 2 – Evaluation of nanoparticles toxicity at different biological organization levels: cells, organelles and biopolymers: 3 teaching hours x 1 group (1 teaching hour = 45 minutes) = 3 teaching hours total (laboratory classes: NO);
Part 3 – Development of topical pharmaceutical products, penetration tests and other analytical procedures: 4 teaching hours x 1 group (1 teaching hour = 45 minutes) = 4 teaching hours total (laboratory classes: YES);
Part 4 – Preparation technologies of natural raw materials: 2 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 4 teaching hours total (laboratory classes: YES);
Part 5 – Influence of innovative technologies on preparation and quality of medicinal and aromatic plants raw material: 3 teaching hours x 1 group (1 teaching hour = 45 minutes) = 3 teaching hours total (laboratory classes: NO);
Part 6 – Technologies for the evaluation of biological environmental factors: 2 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 4 teaching hours total (laboratory classes: YES);
Part 7 – Processes and apparatus in biopharmaceutical industry: 2 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 4 teaching hours total (laboratory classes: YES);
Part 8 – Drug and gene delivery into cells using cell electroporation: 3 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 6 teaching hours total (laboratory classes: YES);
Part 9 – Rules of instrumentation designing, methodology of 3D printing for biotechnology, analytical procedures and data extraction: 3 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 6 teaching hours total (laboratory classes: YES);
Part 10 – Basics of fermentation and purification of metabolites: 3 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 6 teaching hours total (laboratory classes: YES);
Part 11 – Miniaturization of analytical tools and application for qualitative and quantitative analysis of biomolecules: 3 teaching hours x 2 groups (1 teaching hour = 45 minutes) = 6 teaching hours total (laboratory classes: YES).
10)	Form of class:
- providing basic theoretical information and group work in the form of workshops and case studies under the guidance of the trainer;
- consultation of actions taken, feedback;
- working in groups of 12 (for parts 2, 3, 5) or 6 (for parts 1, 4, 6-11);
- laboratory classes (applies to all parts of the procurement except for: 2, 5);
- group discussions, discussions moderated by the trainer;
- the classes will be conducted in a form activating all participants.
11)	Organizational issues related to the execution of the subject matter of the procurement:
- verification of the training needs of the participants before starting the classes;
- preparation of questions for the knowledge and competence test in the scope of the activities conducted by the Contractor in order to demonstrate the acquisition of knowledge and increase the competence of participants as a result of participation in the classes. Questions for the test will be forwarded to the administrative coordinator;
- preparation of training materials in a printed form for each participant (course outline, bibliography, case studies, etc.) and 1 copy for the Contracting Authority for project purposes (archiving) in an electronic version, containing relevant logos and information about the project being co-financed from the European Social Fund. The content of information and logotypes will be provided by the Contracting Authority after signing the contract;
- all classes will be conducted in English;
- preparation, collection and handover of the necessary documentation from the classes: the originals of the attendance lists, class books and confirmation of receipt of certificates, on bilingual templates provided by the Contracting Authority to the person indicated by the Contracting Authority;
- certificates confirming participation in the workshops, including logos and the name of the project will be prepared by the summer school's administrative coordinator and will require the signature of the content coordinator;
- the final report will be prepared by the administrative coordinator of the summer school, however, its preparation will require a substantive contribution from each of the Contractors, including the description of competences acquired by the participants of the summer school.
During the first hour of classes, the Contractor will inform the participants about the co-financing of the summer school from the European Social Fund within the project entitled: "Interdisciplinary, international doctoral studies in medical biology and pharmaceutical sciences at the Medical University of Bialystok".
The Contractor shall ensure that the service which is the subject matter of the procurement is adequately accessible to all participants of the classes, in accordance with the standards attached as an annex to the Guidelines for the implementation of the principle of equal opportunities and non-discrimination, including accessibility for persons with disabilities and the principle of equal opportunities for women and men under EU funds for the years 2014-2020, and that the policy of equal opportunities is respected in the implementation of the classes, in particular the use of equality language.
The Contracting Authority provides for breaks: in the case of classes lasting 3 and 4 teaching hours, there will be one 15-minute break. In the case of classes lasting 6 teaching hours, the Contracting Authority provides for two 15-minute breaks. Breaks do not count towards the total duration of the classes covered by this Request for Proposal.
The administrative coordinator supervising the Kaunas Summer School and providing logistical and administrative support will be provided by Vytautas Magnus University under separate agreements between the Medical University of Bialystok and Vytautas Magnus University. The tasks of the administrative coordinator will include organizational issues, coordinating the implementation of the summer school schedule, booking rooms for lectures and laboratories for experimental work, providing equipment and facilities (laptop, multimedia projector, etc.), delivering the necessary reagents and small consumable equipment to the place where the classes are conducted, organizational assistance in the course of the summer school, solving possible problems.
14) Requirements for the Contractors conducting classes (common for all parts):
- holding a PhD degree (at least);
- having at least 10 years of professional experience in the subject the classes will be conducted on;
- the teacher should be a recognised authority in the field of biomedical, biopharmaceutical sciences on a global scale;
- a very good knowledge of English;
- having scientific achievements related to the subject matter of the classes, for example, having publications in magazines indexed in the Scopus and Web of Science databases;
- availability during the period of the planned service.
3.	Evaluation criteria:
Tenders will be evaluated by the Contracting Authority separately for all parts of the procurement based on the following criterion:
Offer price - maximum number - 100 points
Principles of evaluation of the 'offer price' criterion
- In the tender form, the Contractor shall provide the gross price for the completion of the procurement in a given part. The assessment in this criterion will be made using a formula:
- Number of points = lowest price offered / price of the rated offer x 100
- The most advantageous offer will receive 100 points in this criterion.
II.	Time limit or period of execution of the procurement
The order will be completed within the period between 22-26 September 2020.
The final date of the service, which falls within the period of 22-26 September 2020, will be determined in a working mode between the Contracting Authority and the Contractor, after signing the contract, at least 30 days in advance of the planned start of the summer school in Kaunas.
III.	Submission of tenders
1.	For details, please contact us at the following address:
Medical University of Bialystok, ul. J. Kilińskiego 1, 15-089 Bialystok, International Cooperation Department, Room 205, Right Wing of the Branicki Palace.
2.	Contact person for the Contractors:
Contact phone number, e-mail address:
+ 48 85 686 52 21, tomasz.maliszewski@umb.edu.pl
3.	The completed bid form (attachment to the Request for Proposal) should include:
1)	A declaration of no personal or capital relationships with the Contracting Authority,
2)	A copy of documents proving professional experience (e.g. curriculum vitae, list of scientific publications, copies of diplomas and other documents etc.).
4.	Tender submission deadline (date and time):
2020-05-20, 03.00 PM
Place: The Medical University of Bialystok
1)	The offer must be submitted in an addressed envelope: Medical University of Bialystok, ul. Jana Kilińskiego 1, 15-089 Bialystok, with a note: “A tender for the preparation and execution of classes as part of the summer school in Kaunas - part ..... - case no. AWM/NCBR/07/2020/TM - Do not open before 20.05.2020, 03:00 PM". When submitting an offer, the date of receipt at the Medical University of Bialystok is decisive. Tenders submitted or received after the above-mentioned deadline will not be considered.
2)	The offer should be submitted in person, via e.g. the Polish Post Office or courier service at the General Office of the Medical University of Bialystok, ul. Jana Kilińskiego 1, 15-089 Bialystok. It is possible to send an offer by e-mail in the form of scans of signed documents, to the e-mail address: tomasz.maliszewski@umb.edu.pl
5.	The Medical University of Bialystok reserves the right:
- to leave the offers received after the deadline without consideration;
- to invalidate the proceedings without providing a reason;
- to change the scope of the proceedings.
Pursuant to art. 13 para. 1 and 2 of the regulation of the European Parliament and of the Council (UE) 2016/679 dated 27th April 2017 on the protection of natural persons in connection to the processing of personal data and on the free movement of such data and the repeal of Directive 95/46 /WE (general data protection regulation) ( OJ EU L 119, 04.05.2016, p. 1), hereinafter referred to as 'the GDPR', I hereby inform you that
	the controller of personal data is the Medical University of Bialystok, ul. Jana Kilińskiego 1, 15-089 Bialystok, NIP 542-021-17-17, REGON 000288604, represented by the Rector;
	The Data Protection Officer’s contact details: iod@umb.edu.pl;
	personal data will be processed pursuant to Article 6(1)(b ) of the GDPR for the purpose of concluding a contract on the basis of an offer submitted and pursuant to Article 6(1)(a) of the GDPR for the purpose of evaluating the offer submitted and contacting the bidder;
	the recipients of personal data may be contractors, persons requesting public information, entities authorized under the provisions of law and entities under concluded entrustment agreements with the Contracting Authority,
	personal data will be stored for the period resulting from legal regulations, i.e. 5 years from the date of termination of the contract,
	providing personal data is voluntary, however, failure to provide such data may prevent the Contracting Authority from evaluating the tender, which will result in the rejection of the tender or exclusion from the procedure;
	with regard to personal data, decisions will not be made by automated means, pursuant to Article 22 of the GDPR;
−	pursuant to Article 15 of the GDPR the right of access to personal data;
−	pursuant to Article 16 of the GDPR, the right to rectify personal data 1;
−	pursuant to Article 18 of the GDPR, the right to request from the controller to restrict the processing of personal data subject to the cases referred to in Article 18(2) of the GDPR2;
−	the right to lodge a complaint with the President of the Office for the Protection of Personal Data, if the Contractor considers that the processing of personal data concerning the Contractor violates the provisions of the GDPR;
	the Contractor is not entitled to the following:
−	in connection with Article 17(3)(b), (d) or (e) of the GDPR, the right to delete personal data;
−	the right to transfer personal data referred to in Article 20 of the GDPR;
−	the right to object to the processing of personal data on the basis of Article 21 of the GDPR, since the legal basis for processing personal data is Article 6(1)(c) of the GDPR.
1 Explanation: The exercise of the right of rectification may not result in a change in the outcome of the competition or in an amendment to the provisions of the contract
2 Explanation: the right to restrict processing does not apply to storage in order to protect the rights of another natural or legal person or for important reasons of public interest of the European Union or a Member State.
1)	The framework scope of the classes in parts 1-11;
2)	The bid form
3)	A declaration of no personal or capital relationships with the Contracting Authority;
4)	A contract template;
5)	A template of the agreement of entrustment of data processing.
Attachment no. 1– The framework scope of the classes in parts 1-11.
Application of ultraviolet filters technologies in cosmetics
Cosmetic Products Development Course
The course provides specific scientific knowledge and skills in cosmetic science and technology.
It provides an understanding of the steps of the development process of a cosmetic product starting from the selection of raw materials to application of the technologies and preparation of a final product.
The course covers topics regarding the evaluation and selection of appropriate preservatives, gums, thickeners, lipids, surfactants, active ingredients in the development of various product formulations. The course will be delivered as a seminar and practical demonstration.
On successful completion of this course, the participants will learn:
•	How to evaluate and select the right type of ingredients for a variety of formulations.
•	How to develop safe and effective skin and hair care products.
Evaluation of nanoparticles toxicity at different biological organization levels: cells, organelles and biopolymers
Controlling the interaction of nanomaterials with biological interfaces is a fundamental challenge to the field of nanomedicine, environmental protection, health, etc. When a nanomaterial enters a physiological environment, its surface is covered with a layer of proteins, forming what is known as the protein ‘corona‘. The protein corona alters the size, aggregation state, and interfacial properties of the nanomaterial, giving it a biological identity that is distinct from its synthetic identity. Uncontrolled nanomaterial–protein interactions can mark a nanomaterial for uptake in off-target cell populations, activate enzymatic cascades and prevent efficient removal from the body. A nanomaterial is safe and can be used effectively for disease diagnostics and treatment only when its physiological response is understood and controlled. Nanoparticles (NPs) toxicity is investigated in different experimental models and at different biological organization levels starting from NPs interaction with small biomolecules and biopolymers, organelles, cells, organs and, finally, assessing the effect on the functions of the entire organism. The data obtained from these experiments are used for filling gaps in the mechanism of NPs toxicity which can differ depending on countless parameters of NPs (material, size, shape, coating, aggregation, etc.) and biological micro and macro environment (composition of membranes, pH of the cellular compartment, cell type, organ system, immune system, etc.).
In this course students will learn how to evaluate the effect of NPs on cell viability by different methods (TPP, PI, LDH assays), ROS generation in cell culture, the effect of NPs on mitochondrial functions in situ and in isolated mitochondria, the effect of NPs on protein structure and fibrilization by UV/VIS spectroscopy, Raman scattering spectroscopy, and synchronous fluorescence.
Development of topical pharmaceutical products, penetration tests and other analytical procedures
Guidelines and related regulatory documents defining the drug product development. Drug products topically administered via the skin for local action and for systemic effects. Practical principles applied in the design of topical and dermal/transdermal drug delivery systems (creams, gels, ointments, pastes, suspensions, lotions, foams, sprays, aerosols, and solutions). Critical pharmaceutical product quality attributes in development of semisolid dosage forms. Pharmaceutical product quality tests and product performance tests as applied for topical and dermal/transdermal drug delivery products.
Experimental evaluation of quality parameters of topical and dermal/transdermal pharmaceutical products (assay, identiﬁcation, content uniformity, pH, microbial limits, minimum ﬁll and other possible compendial tests).
Experimental evaluation of topical and dermal/transdermal drug delivery system performance by applying in vitro release testing, and ex vivo skin penetration/permeation studies.
Statistical approaches for data treatment and evaluation.
Basic considerations that are employed during the development of a semi-solid topical generic products. Implementation of quality by design concepts during development of semisolid generic drug products. Design of bioequivalence studies for demonstration of similarity of topical and dermal/transdermal drug delivery products. Application of important aspects to be considered for demonstration of test-reference product similarity in real life cases – critical analysis and discussion.
Preparation technologies of natural raw materials
The aim of the course is to provide an understanding of the role of sampling and sample preparation of medical plant material in analytical and bioanalytical chemistry. The students will understand sampling consideration and approaches, and sample preparation technologies. By attending the course students will learn the role of sampling, sample types, sample size, sample storage and handling. This course will present the knowledge behind traditional and newly developed chemical extraction methods for sample preparation of medical plant material. Throughout the course both practical and theoretical aspects of the outlined topics and application case studies will be presented.
Influence of innovative technologies on preparation and quality of medicinal and aromatic plants raw material
Influence of innovative technology on the preparation and quality of MAPs raw material
The aim of this course is to gain interdisciplinary theoretical and practical knowledge of Medicinal (aromatic) plants (MAPs) scientific research and the Influence of innovative technology on the preparation and quality of MAPs raw material and evaluation (Pharmacopoeias, WHO Monographs and Guidelines on good collection practices for MAPs) its quality, safety and efficiency.
Study methods: workshop - discussion.
During the workshop Students will analyse and learn:
1.	MAPs are a complementary and traditional systems of medicine.
Students will understand the principles of current trends in Pharmacognosy related to study traditional knowledge on the use of plants in health care.
2.	Standards and juridical documents for the regulation of the quality of MAPs raw material in practice.
the principles of conservation and rational use of the medicinal (aromatic) plants MAPs diversity (Guidelines on the conservation of medicinal plants, 2004);
the general principles of good cultivation of medicinal plants, quality control measures and Good Collection Practices MAPs raw material (WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants, 2003; The European Pharmacopoeia (Ph. Eur.) 9th Edition 2020).
3.	MAPs constitute a source of raw materials. Innovative drying technologies of MAPs raw material.
The development and application of new Innovative drying technologies for the preparation and study of MAPs Raw Materials will be analysed.
4.	Identification and morphological / microscopical examination of MAPs and raw material.
Students will be able to select and apply MAPs raw material characterization scheme to the characteristic’s properties of the investigation object and possibilities of the evaluation methods.
Technologies for the evaluation of biological environmental factors
Norms prepared based on European Union legislation on levels of environmental pollution that do not harm human health. Air pollution is measured in mg/m3. The data obtained is compared with the maximum allowable concentrations. These values are regulated by the hygiene norm. Hygiene standards obligatory for persons designing, developing or operating in technology commercial activities for the monitoring and control of air pollution. There is a very high correlation between the amount of dust and the number of microorganisms indoors. For the contamination description is used term bioaerosols. Bioaerosols are divided into fumes and vapor. Bioaerosols consist of dead and living particles. Dead part – dust, the living part includes bacteria, micromycetes (microscopic fungi), viruses, mites, protozoa. Mycotoxins are quite different chemical compounds with different effects on the body. It may also be inhaled. Spores of microscopic fungi are important carriers of toxins. Bioaerosols can be pathogenic, toxic, allergenic or have pharmacological activity. Mold has been identified by the World Health Organization as one of the causes of lung cancer. Species composition and number of microorganisms in the indoor environment is constant in the dynamic state. Various methods and devices have been developed to clean the polluted air. Depending on the physico-chemical properties of the pollutants, the concentrations in the air and the origin, a method can be chosen. Air purifiers are divided into pre-cleaners and cleaners, according to the cleaning method - dry and wet.
We will look at the classification of bioaerosols, methods for determining the concentration of dust in the air. We will determine the concentration of dust in the air by gravimetric (weighing) method. We will use laboratory analytical scales, air pump to pump contaminated air through the filter, membrane filters, thermometer, manometer. We will determine colonies of micro-organisms in the air (CFU / m3) using in our research the nutrient medium.
Processes and apparatus in biopharmaceutical industry
This course aims to provide a basic knowledge of the theoretical principles of industrial plant and process for biopharmaceuticals, including an overview on major equipment commonly used, materials of construction and detailed economical evaluation of the process. It also aims to provide a basic understanding of the driving forces regulating the equipment selection; a capability to evaluate and select the most appropriate solution for a given practical problem in this area. Particular focus is given to the up-stream treatment and down-stream processing. After completion of the course students will gain basic understanding and have practical experience in solving theoretical problems, show capability in managing basic understanding of drawings, schematics and data elaboration involved in plant and process used in biopharmaceutical industry.
The course includes practicals regarding case studies, and process development and refining the simulation.
Drug and gene delivery into cells using cell electroporation
The targeted and facilitated drug delivery employing cell electroporation has been proved as efficient modality for antitumor electrochemotherapy. Antitumor electrochemotherapy combines administration of anticancer drugs like bleomycin or cisplatin and application of high intensity electric pulses. Electric pulses of certain parameters (pulse shape, strength, duration, number and frequency of pulses) and reversibly or irreversibly permeabilize the cells allowing transmembrane exchanges of various molecules. Therefore, the method can be exploited not only drug delivery, but also for delivery of various nucleic acids (plasmid DNA, siRNA, mRNA, etc.) as well as extraction of various extracellular compounds.
During the practical works, concerning cell electroporation, student will get acquainted with general techniques of cell culture lab. Special attention will be given for cell electroporation experiments, measurement of cell viability and the percentage of cells that uptake drug or gene. All evaluation will be performed by using flow cytometry. Therefore, some practical introduction of the function and capabilities of flow cytometry will be provided.
Rules of instrumentation designing, methodology of 3D printing for biotechnology, analytical procedures and data extraction
The demand for new instruments is increasing. It is influenced by the expanding set of applications. One of the main requirements that drive the development new instruments is portability and operational autonomy. Such instruments are not only smaller copies of their benchtop version, but they also have operational procedures adapted for smaller reagent and sample consumption as only minute quantities of consumables can be carried with the in-situ instrumentation. Designing such instrumentation most difficult challenges are following: (i) power efficiency, (ii) wireless operation, (iii) resilience to changing environment, (iv) user friendliness, (v) operational robustness. Depending on the type of the instrument or the application, more design challenges can be faced. Regardless of the instrument or the application, following rapid prototyping techniques are used: (a) 3D printing, (b) CNC milling, (c) laser cutting, (d) injection molding, (e) printed circuit board design, (f) automation and programming. In addition to this, during development process of the instrument data must be acquired and processed before moving to the next iteration of the instrument design. If the product is supposed to work remotely or autonomously, adequate data transfer means or data pre-processing algorithms should be implemented.
The set of lectures will cover instrumentation design process broadly and methodologies such as 3D printing in detail. Applications for biotechnology and analytics will be addressed. The means to understand acquired data will be presented and demonstrated.
Basics of fermentation and purification of metabolites
Fermentation is a metabolic process, when chemical changes occur in organic substrates because of the action of microorganisms’ secreted enzymes. The knowledge about the use of fermentation reaches ancient times before BC. This process was mainly used for beverage production. The fact, that fermentation is initiated by microorganisms was discovered only in 1860s by Louis Pasteur. Many kinds of food products, such as wine, beer, cheese, yoghurt, kombucha, salami, soya sauce, vinegar, etc. are produced all over the World using fermentation by yeast, bacteria or fungi. In the last century fermentation was successfully applied for the production of antibiotics (penicillin, streptomycin, tetramycin, tetracycline), bacteriocins, vitamins (vitamin B12, biotin, riboflavin), enzymes, biopolymers, some pharmaceuticals (insulin, interferon, erythropoietin), amino acids, etc. All mentioned compounds mainly are metabolites of bacteria and fungi.
Most of the food products produced by applying fermentation can be consumed without additional treatment except strong drinks, when distillation is performed to increase the concentration of ethanol in the beverage. But speaking about vitamins, drugs and pharmaceuticals, amino acids, food additives and other valuable metabolites, the purification and/or concentration process must follow fermentation. Different purification/concentration methods, such as solvent extraction, membrane filtration, chromatography, electrophoresis, etc. nowadays are used for isolation of microorganisms’ metabolites after fermentation.
During the summer school, students will gain knowledge about the usage of fermentation in medicine and pharmacy together with practical experience in fermentation and purification of the metabolites.
Miniaturization of analytical tools and application for qualitative and quantitative analysis of biomolecules
Due to high complexity the real samples of biological origin require separation step prior to analysis. Analytical separation techniques are commonly coupled with qualitative and qualitative detectors for determination of composition of the sample analysed. A common trend in modern analysis is not only coupling of methods but also miniaturization of instruments and increase of throughput of samples. During this presentation, the PhD students will be introduced with the main principles of miniaturization of analytical techniques, the limitations and prospects in this fast-growing research field.
During the hands-on seminar students will practically separate biologically active compounds using different separation and detection modes.
2020-09-22 - 2020-09-26
Twenty-sixth of September, two thousand and twenty
Tomasz Maliszewski, PhD
The completed bid form (attachment to the Request for Proposal) should include:
Place: The Medical University of Bialystok 1)	The offer must be submitted in an addressed envelope: Medical University of Bialystok, ul. Jana Kilińskiego 1, 15-089 Bialystok, with a note: “A tender for the preparation and execution of classes as part of the summer school in Kaunas - part ..... - case no. AWM/NCBR/07/2020/TM - Do not open before 20.05.2020, 03:00 PM". When submitting an offer, the date of receipt at the Medical University of Bialystok is decisive. Tenders submitted or received after the above-mentioned deadline will not be considered. 2)	The offer should be submitted in person, via e.g. the Polish Post Office or courier service at the General Office of the Medical University of Bialystok, ul. Jana Kilińskiego 1, 15-089 Bialystok. It is possible to send an offer by e-mail in the form of scans of signed documents, to the e-mail address: tomasz.maliszewski@umb.edu.pl
The Medical University of Bialystok reserves the right:
to leave the offers received after the deadline without consideration,
to invalidate the proceedings without providing a reason,
to change the scope of the proceedings.
request_for_proposal.docx 468.62 KB
contract_-_template.docx 457.07 KB
agreement_for_entrusting_the_processing_of_personal_data.docx 455.75 KB
bid_form.docx 453.3 KB
declaration_of_lack__of_personal_or_capital_relationships.docx 447.98 KB
information_on_the_selection_of_contractors.pdf 242.93 KB