Source: http://www.google.com/patents/US8017107?dq=6,587,403
Timestamp: 2016-02-07 04:47:41
Document Index: 643109651

Matched Legal Cases: ['Application No. 050010009', 'Application No. 06255568', 'Application No. 06256452', 'Application No. 06256525', 'Application No. 06256525', 'Application No. 06256525']

Patent US8017107 - Perfluorocyclobutane crosslinked hydrogels - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsThis invention provides water-swellable articles and hydrogels that contain a hydrophilic polymer and perfluorocyclobutane crosslinking segments. The perfluorocyclobutane crosslinking segments are covalently attached to the polymeric chains of the hydrophilic polymer so that the crosslinking segments...http://www.google.com/patents/US8017107?utm_source=gb-gplus-sharePatent US8017107 - Perfluorocyclobutane crosslinked hydrogelsAdvanced Patent SearchPublication numberUS8017107 B2Publication typeGrantApplication numberUS 11/614,389Publication dateSep 13, 2011Filing dateDec 21, 2006Priority dateDec 22, 2005Fee statusPaidAlso published asDE602006017160D1, EP1801135A1, EP1801135B1, US20070154429Publication number11614389, 614389, US 8017107 B2, US 8017107B2, US-B2-8017107, US8017107 B2, US8017107B2InventorsBrian Thomas, Kai ZhangOriginal AssigneeZimmer, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (238), Non-Patent Citations (100), Classifications (41), Legal Events (2) External Links: USPTO, USPTO Assignment, EspacenetPerfluorocyclobutane crosslinked hydrogels
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Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3200178Dec 7, 1961Aug 10, 1965Kurashiki Rayon CoPolyvinyl alcohol spinning solutions and fibers produced therefromUS3862265Apr 3, 1972Jan 21, 1975Exxon Research Engineering CoPolymers with improved properties and process thereforUS3875302Aug 7, 1973Apr 1, 1975Kuraray CoGelled vinyl alcohol polymers and articles therefromUS4036788Feb 11, 1975Jul 19, 1977Plastomedical Sciences, Inc.Anionic hydrogels based on heterocyclic N-vinyl monomersUS4058491Feb 11, 1975Nov 15, 1977Plastomedical Sciences, Inc.Cationic hydrogels based on heterocyclic N-vinyl monomersUS4060678Feb 11, 1975Nov 29, 1977Plastomedical Sciences, Inc.Cationic hydrogels based on hydroxyalkyl acrylates and methacrylatesUS4071508Feb 11, 1975Jan 31, 1978Plastomedical Sciences, Inc.Anionic hydrogels based on hydroxyalkyl acrylates and methacrylatesUS4279795Dec 28, 1973Jul 21, 1981Kuraray Co., Ltd.Hydrophilic-hydrophobic graft copolymers for self-reinforcing hydrogelsUS4300820Oct 27, 1980Nov 17, 1981The Kendall CompanyWater absorptive compositionUS4379874Jul 7, 1980Apr 12, 1983Stoy Vladimir APolymer composition comprising polyacrylonitrile polymer and multi-block copolymerUS4451599Apr 19, 1982May 29, 1984American Can CompanyPlasticized EVOH and process and products utilizing sameUS4451630Jun 16, 1983May 29, 1984Atkinson Ivor BHydrogel contact lenses for permanent wearUS4464438May 2, 1983Aug 7, 1984Mobil Oil CorporationBlends of polyvinyl alcohol and ethylene-vinyl alcohol copolymer as grease resistant melt extrudable filmsUS4472542Aug 8, 1983Sep 18, 1984Nippon Oil Co., Ltd.Freeze-dried polyvinyl alcohol gelUS4640941Jan 7, 1986Feb 3, 1987Alcon LaboratoriesHydrogels containing siloxane comonomersUS4656216Mar 19, 1985Apr 7, 1987Mueller AlbrechtThermoplastically processable polyvinyl alcohol compositions, process for their preparation, and films and moldings prepared from themUS4663358Apr 25, 1986May 5, 1987Biomaterials Universe, Inc.Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the sameUS4664857Jun 27, 1985May 12, 1987Nippon Oil Company, LimitedProcess for preparing a hydrogelUS4699146Sep 12, 1985Oct 13, 1987Valleylab, Inc.Hydrophilic, elastomeric, pressure-sensitive adhesiveUS4734097Mar 28, 1985Mar 29, 1988Nippon Oil Company, Ltd.Medical material of polyvinyl alcohol and process of makingUS4771089Jul 10, 1985Sep 13, 1988Minnesota Mining And Manufacturing Co.Polymer blends with high water absorptionUS4772287Aug 20, 1987Sep 20, 1988Cedar Surgical, Inc.Prosthetic disc and method of implantingUS4808353Jan 8, 1986Feb 28, 1989Nippon Oil Co., Ltd.Process for preparing an artificial biological membraneUS4842597May 15, 1987Jun 27, 1989Fulmer Yarsley Ltd.Hydrophilic copolymers for wound dressings and other biomedical usesUS4851168Dec 28, 1988Jul 25, 1989Dow Corning CorporationNovel polyvinyl alcohol compositions and products prepared therefromUS4859719Jun 13, 1988Aug 22, 1989Minnesota Mining And Manufacturing CompanyPolymer blends with high water absorptionUS4871490Dec 30, 1987Oct 3, 1989Politechnika Lodzka, Lodz, Ul. ZwirkiMethod of manufacturing hydrogel dressingsUS4874562Feb 9, 1987Oct 17, 1989Biomaterials Universe, Inc.Method of molding a polyvinyl alcohol contact lensUS4915974Feb 17, 1989Apr 10, 1990Nabisco Brands, Inc.Polyvinyl oleate as a fat replacementUS4956133Nov 16, 1988Sep 11, 1990Le Roy PayneContinuous molding apparatus and methodUS4966924May 15, 1989Oct 30, 1990Biomaterials Universe, Inc.Soft contact lens and method of manufacturing the sameUS4988761Apr 26, 1989Jan 29, 1991Dow Corning K.K.Process for producing a low water content PVA hydrogelUS5028648Jul 12, 1990Jul 2, 1991Air Products And Chemicals, Inc.Extrudable polyvinyl alcohol compositions containing thermoplastic polyurethaneUS5047055Dec 21, 1990Sep 10, 1991Pfizer Hospital Products Group, Inc.Hydrogel intervertebral disc nucleusUS5053455Feb 20, 1991Oct 1, 1991Hoechst AgGraft polymers, containing polyvinyl acetal groups, on polyurethane grafting substrates, processes for the preparation thereof, and the use thereforUS5106876Sep 20, 1989Apr 21, 1992Terumo Kabushiki KaishaWater-insoluble hydrogel and method for production thereof by using radiation, freezing and thawingUS5118779Oct 10, 1989Jun 2, 1992Polymedica Industries, Inc.Hydrophilic polyurethane elastomersUS5122565Oct 26, 1990Jun 16, 1992Shell Oil CompanyStabilized polyketone polymers containing a mixture of a hydroxyapatite and an alumina hydrogelUS5157093May 9, 1991Oct 20, 1992Ciba-Geigy CorporationHydroxyethyl cellulose derivatives containing pendant (meth)acryloyl units bound through urethane groups and hydrogel contact lenses made therefromUS5189097Oct 22, 1991Feb 23, 1993Rohm And Haas CompanyPolymeric blendsUS5192326Sep 9, 1991Mar 9, 1993Pfizer Hospital Products Group, Inc.Hydrogel bead intervertebral disc nucleusUS5244799Dec 17, 1991Sep 14, 1993Anderson David MPreparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrateUS5276079Nov 15, 1991Jan 4, 1994Minnesota Mining And Manufacturing CompanyPressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using sameUS5288503Jun 16, 1992Feb 22, 1994Srchem IncorporatedCryogel oral pharmaceutical composition containing therapeutic agentUS5306311Dec 17, 1991Apr 26, 1994Regen CorporationProsthetic articular cartilageUS5311223Jun 7, 1993May 10, 1994Johnson & Johnson Vision Products, Inc.Ophthalmic lens polymer incorporating acyclic monomerUS5315478Oct 16, 1991May 24, 1994Fujitsu Personal Systems, Inc.Memory card tray for portable computerUS5334634Aug 13, 1991Aug 2, 1994Novamont S.P.A.Polymer compositions for the production of articles of biodegradable plastics material and methods for their preparationUS5336551Dec 14, 1992Aug 9, 1994Mizu Systems, Inc.Reinforced polyvinyl alcohol hydrogels containing uniformly dispersed crystalline fibrils and method for preparing sameUS5358525Dec 28, 1992Oct 25, 1994Fox John EBearing surface for prosthesis and replacement of meniscal cartilageUS5360830Feb 18, 1994Nov 1, 1994Novamont S.P.A.Expanded articles of biodegradable plastic materialsUS5362803Jul 16, 1993Nov 8, 1994Rohm And Haas CompanyPolymeric blends of polyvinyl alcohol copolymers with copolymers of unsaturated monomersUS5364547 *Apr 26, 1993Nov 15, 1994The Dow Chemical CompanyLubricants containing perfluorocyclobutane ringsUS5407055Nov 16, 1993Apr 18, 1995Kao CorporationConveyor apparatus and method having flexible goods receptacle membersUS5409966Oct 15, 1993Apr 25, 1995Minnesota Mining And Manufacturing CompanyMethod for producing pressure sensitive poly (N-vinyl lactam)US5410016Mar 1, 1993Apr 25, 1995Board Of Regents, The University Of Texas SystemPhotopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriersUS5458643Feb 1, 1994Oct 17, 1995Kyocera CorporationArtificial intervertebral discUS5527271Mar 30, 1994Jun 18, 1996Bristol-Myers Squibb Co.Thermoplastic hydrogel impregnated composite materialUS5540033Jan 10, 1994Jul 30, 1996Cambrex HydrogelsIntegrated Manufacturing process for hydrogelsUS5552096May 31, 1995Sep 3, 1996Exxon Chemical Patents Inc.Multiple reaction process in melt processing equipmentUS5576072Feb 1, 1995Nov 19, 1996Schneider (Usa), Inc.Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogelUS5580938Oct 22, 1991Dec 3, 1996Hoechst AktiengesellschaftGraft polyvinyl acetals having acetal groups from etherified ω-hydroxy(poly)alkoxyalkanals, processes for their preparation and their useUS5624463Apr 25, 1994Apr 29, 1997Regen Biologics, Inc.Prosthetic articular cartilageUS5632774May 14, 1996May 27, 1997Babian; HamikIn-the-shell hydration to make implant filler material and prosthesis employing sameUS5674295Apr 26, 1996Oct 7, 1997Raymedica, Inc.Prosthetic spinal disc nucleusUS5681300Nov 27, 1995Oct 28, 1997The Procter & Gamble CompanyAbsorbent article having blended absorbent coreUS5705296Jun 7, 1995Jan 6, 1998Mitsubishi Cable Industries, Ltd.Lithium secondary batteryUS5709854Apr 30, 1993Jan 20, 1998Massachusetts Institute Of TechnologyTissue formation by injecting a cell-polymeric solution that gels in vivoUS5711960May 24, 1995Jan 27, 1998Takiron Co., Ltd.Biocompatible implant material comprising a tri-axial or more three-dimensional fabricUS5716404Dec 16, 1994Feb 10, 1998Massachusetts Institute Of TechnologyBreast tissue engineeringUS5723311Jun 2, 1995Mar 3, 1998Human Genome Sciences, Inc.Human DNA topoisomerase I αUS5723331Jun 6, 1995Mar 3, 1998Genzyme CorporationMethods and compositions for the repair of articular cartilage defects in mammalsUS5834029Jul 20, 1994Nov 10, 1998Cytotherapeutics, Inc.Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragmentUS5879713Jan 23, 1997Mar 9, 1999Focal, Inc.Targeted delivery via biodegradable polymersUS5891826Nov 26, 1997Apr 6, 1999Eastman Kodak CompanyAffixing thermal dye transfer image on magnetUS5941909Aug 7, 1997Aug 24, 1999Mentor CorporationFilling material for soft tissue implant prostheses and implants made therewithUS5976186Jun 25, 1996Nov 2, 1999Stryker Technologies CorporationHydrogel intervertebral disc nucleusUS5981826Sep 17, 1997Nov 9, 1999Georgia Tech Research CorporationPoly(vinyl alcohol) cryogelUS6015576Aug 29, 1997Jan 18, 2000Bio-Sphere Technology, Inc.Method for inducing a systemic immune response to an antigenUS6017577Feb 1, 1995Jan 25, 2000Schneider (Usa) Inc.Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devicesUS6040493Apr 24, 1998Mar 21, 2000Replication Medical, Inc.Bioreactor wound dressingUS6080488Mar 24, 1998Jun 27, 2000Schneider (Usa) Inc.Process for preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coating, coated polymer and metal substrate materials, and coated medical devicesUS6117449Jan 14, 1998Sep 12, 2000Bio-Sphere Technology, Inc.Method for inducing a systemic immune response to a hepatitis antigenUS6120904May 24, 1999Sep 19, 2000Schneider (Usa) Inc.Medical device coated with interpenetrating network of hydrogel polymersUS6121341Mar 22, 1996Sep 19, 2000Board Of Regents, The University Of Texas SystemRedox and photoinitiator systems for priming and improved adherence of gels to substratesUS6129761Jun 7, 1995Oct 10, 2000Reprogenesis, Inc.Injectable hydrogel compositionsUS6129791Sep 2, 1999Oct 10, 2000Japan As Represented By Director General Of National Research Institute For MetalsOxides dispersion steel and making process thereofUS6132468Sep 10, 1998Oct 17, 2000Mansmann; Kevin A.Arthroscopic replacement of cartilage using flexible inflatable envelopesUS6139963Nov 20, 1997Oct 31, 2000Kuraray Co., Ltd.Polyvinyl alcohol hydrogel and process for producing the sameUS6146686Apr 23, 1999Nov 14, 2000Isotis B.V.Implant material and process for using itUS6156345Dec 21, 1999Dec 5, 2000Surmodics, Inc.Crosslinkable macromers bearing initiator groupsUS6156572Sep 25, 1998Dec 5, 2000Neurotech S.A.Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragmentUS6162456Sep 24, 1992Dec 19, 2000Ortho-Mcneil Pharmaceutical, Inc.Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymersUS6180132Sep 17, 1998Jan 30, 2001Sherwood Services, AgHydrogel wound dressing and the method of making and using the sameUS6180606Jan 13, 1998Jan 30, 2001Gensci Orthobiologics, Inc.Compositions with enhanced osteogenic potential, methods for making the same and uses thereofUS6184197Sep 10, 1997Feb 6, 2001The Procter & Gamble CompanyPolymeric compound comprising one or more active alcoholsUS6187048May 23, 1995Feb 13, 2001Surgical Dynamics, Inc.Intervertebral disc implantUS6207185Oct 10, 1997Mar 27, 2001Bio-Sphere TechnologyMethod for inducing a systemic immune response to an HIV antigenUS6211296Oct 29, 1999Apr 3, 2001The B. F. Goodrich CompanyHydrogels containing substancesUS6224893May 23, 1997May 1, 2001Massachusetts Institute Of TechnologySemi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineeringUS6231605Mar 17, 1999May 15, 2001Restore TherapeuticsPoly(vinyl alcohol) hydrogelUS6232406Sep 30, 1999May 15, 2001Replication Medical Inc.Hydrogel and method of makingUS6238691Oct 22, 1997May 29, 2001Sherwood Services AgHydrogel wound dressing and the method of making and using the sameUS6268405May 4, 1999Jul 31, 2001Porex Surgical, Inc.Hydrogels and methods of making and using sameUS6271278May 13, 1997Aug 7, 2001Purdue Research FoundationHydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent propertiesUS6280475Sep 2, 1999Aug 28, 2001Stryker Technologies CorporationHydrogel intervertebral disc nucleus implantation methodUS6306424Dec 21, 1999Oct 23, 2001Ethicon, Inc.Foam composite for the repair or regeneration of tissueUS6365149Dec 19, 2000Apr 2, 2002Ethicon, Inc.Porous tissue scaffoldings for the repair or regeneration of tissueUS6371984Sep 13, 1999Apr 16, 2002Keraplast Technologies, Ltd.Implantable prosthetic or tissue expanding deviceUS6372283Apr 2, 1999Apr 16, 2002Medtronic, Inc.Plasma process for surface modification of pyrolitic carbonUS6375634Apr 6, 1999Apr 23, 2002Oncology Innovations, Inc.Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapyUS6387325Oct 8, 1999May 14, 2002Becton Dickinson & CompanyAssembly for separating formed constituents from a liquid constituent in a complex biologic fluid sampleUS6402784Jul 10, 1998Jun 11, 2002Aberdeen Orthopaedic Developments LimitedIntervertebral disc nucleus prosthesisUS6443988Nov 18, 1998Sep 3, 2002Disc Dynamics, Inc.Mold apparatus and kit for in situ tissue repairUS6509098Nov 17, 1995Jan 21, 2003Massachusetts Institute Of TechnologyPoly(ethylene oxide) coated surfacesUS6531147Nov 7, 2001Mar 11, 2003Focal, Inc.Compliant tissue sealantsUS6533817Jun 5, 2000Mar 18, 2003Raymedica, Inc.Packaged, partially hydrated prosthetic disc nucleusUS6583219Mar 13, 2002Jun 24, 2003Cornell Research Foundation, Inc.Hydrogel-forming system with hydrophobic and hydrophilic componentsUS6602952Jun 8, 2000Aug 5, 2003Shearwater CorporationHydrogels derived from chitosan and poly(ethylene glycol) or related polymersUS6608117May 11, 2001Aug 19, 2003Nanosystems Research Inc.Methods for the preparation of cellular hydrogelsUS6620196Aug 30, 2000Sep 16, 2003Sdgi Holdings, Inc.Intervertebral disc nucleus implants and methodsUS6626945Feb 28, 2001Sep 30, 2003Chondrosite, LlcCartilage repair plugUS6629997Mar 27, 2001Oct 7, 2003Kevin A. MansmannMeniscus-type implant with hydrogel surface reinforced by three-dimensional meshUS6630457Sep 18, 1998Oct 7, 2003Orthogene LlcFunctionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using sameUS6632246Mar 14, 2000Oct 14, 2003Chondrosite, LlcCartilage repair plugUS6645517Jun 5, 2002Nov 11, 2003William Rice Marsh Rice UniversityTemperature-sensitive polymer/nanoshell composites for photothermally modulated drug deliveryUS6692738Jan 26, 2001Feb 17, 2004The General Hospital CorporationDelivery of therapeutic biologicals from implantable tissue matricesUS6706690Jun 10, 1999Mar 16, 2004Baxter Healthcare CorporationHemoactive compositions and methods for their manufacture and useUS6709668Feb 21, 2003Mar 23, 2004Cornell Research Foundation, Inc.Hydrogel-forming system with hydrophobic and hydrophilic componentsUS6710104May 25, 2001Mar 23, 2004Kawamura Institute Of Chemical ResearchOrganic/inorganic hybrid hydrogel and manufacturing method thereforUS6710126Nov 15, 2000Mar 23, 2004Bio Cure, Inc.Degradable poly(vinyl alcohol) hydrogelsUS6723781Aug 29, 2000Apr 20, 2004Noveon Ip Holdings Corp.Hydrogels containing substancesUS6730298Jan 20, 1998May 4, 2004Massachusetts Institute Of TechnologyTissue formation by injecting a cell-polymeric solution that gels in vivoUS6733533Nov 19, 2002May 11, 2004Zimmer Technology, Inc.Artificial spinal discUS6780840Oct 9, 2001Aug 24, 2004Tissue Adhesive Technologies, Inc.Method for making a light energized tissue adhesiveUS6783546Mar 22, 2001Aug 31, 2004Keraplast Technologies, Ltd.Implantable prosthetic or tissue expanding deviceUS6783721Oct 30, 2001Aug 31, 2004Howmedica Osteonics Corp.Method of making an ion treated hydrogelUS6803420May 1, 2002Oct 12, 2004Corium InternationalTwo-phase, water-absorbent bioadhesive compositionUS6852772Sep 24, 2002Feb 8, 2005Massachusetts Gerneral HospitalHigh modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the meltUS6855743Oct 29, 2001Feb 15, 2005Nanosystems Research, Inc.Reinforced, laminated, impregnated, and composite-like materials as crosslinked polyvinyl alcohol hydrogel structuresUS6861067Jan 30, 2001Mar 1, 2005Sherwood Services AgHydrogel wound dressing and the method of making and using the sameUS7235592Oct 12, 2004Jun 26, 2007Zimmer GmbhPVA hydrogelUS7531000Sep 24, 2007May 12, 2009Zimmer, Inc.Cartilage implantUS20010026810Jan 30, 2001Oct 4, 2001Mcghee DianeHydrogel wound dressing and the method of making and using the sameUS20010032019Mar 8, 2001Oct 18, 2001Southwest Research Institute And Keraplast TechnolImplantable prosthetic or tissue expanding deviceUS20010049417Jan 4, 2001Dec 6, 2001The B.F. Goodrich CompanyHydrogels containing substancesUS20010053897Jan 4, 2001Dec 20, 2001The B.F. Goodrich CompanyHydrogels containing substancesUS20020022884Mar 27, 2001Feb 21, 2002Mansmann Kevin A.Meniscus-type implant with hydrogel surface reinforced by three-dimensional meshUS20020026244Aug 30, 2001Feb 28, 2002Trieu Hai H.Intervertebral disc nucleus implants and methodsUS20020029083Mar 22, 2001Mar 7, 2002Zucherman James F.Implantable prosthetic or tissue expanding deviceUS20020049498Oct 24, 2001Apr 25, 2002Yuksel K. UmitIn situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprostheticsUS20020131952Dec 6, 2001Sep 19, 2002Hennink Wilhelmus EverhardusHydrolysable hydrogels for controlled releaseUS20020151979Oct 25, 2001Oct 17, 2002Lambrecht Greg H.Devices and method for nucleus pulposus augmentation and retentionUS20020173855Feb 8, 2002Nov 21, 2002Mansmann Kevin A.Cartilage repair implant with soft bearing surface and flexible anchoring deviceUS20020193531Jul 11, 2002Dec 19, 2002Replication Medical, Inc.Method of making synthetic hydrophilic polymers and products resulting therefromUS20030008396Jul 19, 2002Jan 9, 2003Ku David N.Poly(vinyl alcohol) hydrogelUS20030065389Aug 27, 2001Apr 3, 2003Jens PetersenPolyacrylamide hydrogel for arthritisUS20030080465Oct 30, 2001May 1, 2003Paul HighamIon treated hydrogelUS20030099709Jul 8, 2002May 29, 2003Amgen Inc.Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agentsUS20030130427May 1, 2002Jul 10, 2003Cleary Gary W.Two-phase, water-absorbent bioadhesive compositionUS20030152528Feb 5, 2003Aug 14, 2003Parminder SinghHydrogel compositions for tooth whiteningUS20030170308May 1, 2002Sep 11, 2003Cleary Gary W.Hydrogel compositionsUS20030195628Feb 13, 2003Oct 16, 2003Qi-Bin BaoMethod of making an intervertebral disc prosthesisUS20030232895Apr 22, 2003Dec 18, 2003Hossein OmidianHydrogels having enhanced elasticity and mechanical strength propertiesUS20030236323Jan 9, 2003Dec 25, 2003Ratner Buddy D.Hydrogels formed by non-covalent linkagesUS20040002764Apr 30, 2003Jan 1, 2004Raymedica, Inc.Self-transitioning spinal disc anulus occlusion device and method of useUS20040005423Feb 13, 2003Jan 8, 2004Dalton Paul D.Method of producing structures using centrifugal forcesUS20040030392May 21, 2003Feb 12, 2004Lambrecht Greg. H.Method of supporting nucleus pulposusUS20040039447Aug 28, 2003Feb 26, 2004Ultra Tec Manufacturing, Inc.Cartilage repair plugUS20040092653Jul 31, 2003May 13, 2004Cambridge Polymer Group, Inc.Systems and methods for controlling and forming polymer gelsUS20040096509Nov 15, 2002May 20, 2004Hutchens Stacy A.Composite materialUS20040116641Oct 10, 2003Jun 17, 2004Mather Patrick T.Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segmentsUS20040121951May 28, 2003Jun 24, 2004Rhee Woonza M.Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositionsUS20040127618Nov 24, 2003Jul 1, 2004Herbert UlmerTough polymersUS20040127992Dec 31, 2002Jul 1, 2004Serhan Hassan A.Annular nucleus pulposus replacementUS20040131582Feb 26, 2002Jul 8, 2004Grinstaff Mark W.Novel dendritic polymers and their biomedical usesUS20040133280Nov 20, 2003Jul 8, 2004Trieu Hai H.Systems and techniques for interbody spinal stabilization with expandable devicesUS20040143329Jan 5, 2004Jul 22, 2004Ku David N.Poly(vinyl alcohol) hydrogelUS20040147673Jan 8, 2004Jul 29, 2004Anthony CalabroHydroxyphenyl cross-linked macromolecular network and applications thereofUS20040153163Jan 31, 2003Aug 5, 2004Howmedica Osteonics Corp.Meniscal and tibial implantsUS20040161444Dec 18, 2003Aug 19, 2004The Regents Of The University Of CaliforniaBiocompatible hydrogel bone-like compositesUS20040171740Feb 4, 2004Sep 2, 2004Cambridge Polymer Group, Inc.Systems and methods for controlling and forming polymer gelsUS20040199250Apr 26, 2004Oct 7, 2004Fell Barry M.Surgically implantable knee prosthesisUS20040220296Apr 30, 2004Nov 4, 2004Lowman Anthony M.Thermogelling polymer blends for biomaterial applicationsUS20040242770Apr 14, 2004Dec 2, 2004Feldstein Mikhail M.Covalent and non-covalent crosslinking of hydrophilic polymers and adhesive compositions prepared therewithUS20040244978 *Jun 4, 2004Dec 9, 2004Sun Drilling Products CorporationLost circulation material blend offering high fluid loss with minimum solidsUS20050004560Jul 21, 2004Jan 6, 2005Microvention, Inc.Medical devices having full or partial polymer coatings and their methods of manufactureUS20050027069Jun 21, 2004Feb 3, 2005Rhee Woonza M.Method for preparing a biocompatible crosslinked matrix and matrix prepared therebyUS20050048103Oct 12, 2004Mar 3, 2005Cleary Gary W.Two-phase, water-absorbent bioadhesive composition for delivery of an active agent to a patientUS20050049365Oct 12, 2004Mar 3, 2005Cleary Gary W.Method for preparing a two-phase water-absorbent bioadhesive compositionUS20050075454Mar 16, 2004Apr 7, 2005Isp Investments Inc.Process of making polymeric hydrogels by reactive extrusionUS20050095296Nov 1, 2004May 5, 2005Lowman Anthony M.Hydrogel compositions and manufacturing process for ultrasound couplantsUS20050107561Jun 30, 2004May 19, 2005Jae-Suk LeeSiloxane monomer containing trifluorovinylether group and sol-gel hybrid polymer prepared by using the sameUS20050197441Mar 4, 2005Sep 8, 2005The Nippon Synthetic Chemical Industry Co., Ltd.Aqueous emulsion and use thereofUS20060078587Nov 22, 2005Apr 13, 2006Koon-Wah LeongHydrophilic coatings for medical implementsUS20060141002Feb 22, 2006Jun 29, 2006Jiankai LiuCoated implants and methods of coatingUS20060188487Feb 21, 2006Aug 24, 2006Zimmer Technology, Inc.Blend hydrogels and methods of makingUS20070004861Jul 1, 2005Jan 4, 2007Kevin CaiHigh melt strength polypropylene resins and method for making sameUS20070202323Feb 28, 2006Aug 30, 2007Kleiner Lothar WCoating construct containing poly (vinyl alcohol)US20070293651Aug 4, 2004Dec 20, 2007Toshio TadaProcess for Producing Polyvinyl Acetal Resin, Polyvinyl Butyral Resin, and Process for Producing Esterified Polyvinyl Alcohol ResinUS20080090145Jan 14, 2005Apr 17, 2008Akio HiwaraPolyvinyl Acetal Resin Varnish Gelling Agent, Nonaqueous Electrolyte Solution, And Electrochemical DeviceUS20090053318Aug 20, 2008Feb 26, 2009Sharon Mi Lyn TanForming Embolic ParticlesEP0256293B1Jul 8, 1987Jun 3, 1992Mitsubishi Kasei CorporationProcess for producing porous cross-linked polyvinyl alcohol particlesEP0290616B1Nov 4, 1987Feb 17, 1993Sumitomo Bakelite Company LimitedGamma ray sterilization process for polyvinyl alcohol gelEP0365108A2Apr 25, 1989Apr 25, 1990Mizu Systems, Inc.Low water content polyvinyl alcohol hydrogel and artificial cartilageEP0505634B1Apr 26, 1991Aug 20, 1997Kyocera CorporationA prosthesisEP0696210B1Apr 21, 1994Sep 2, 1998Laboratoires SebbinUse of hyaluronic acid and/or polydeoxyribonucleotide based hydrogels as materials for filling prostheses and prostheses obtainedEP0738762A1Apr 16, 1996Oct 23, 1996Sumitomo Chemical Company LimitedResin compositionsEP0784987B1Jan 8, 1997Oct 1, 2003Mentor CorporationMethod of making in situ filler material for mammary, penile and testicular prosthesis and tissue expandersEP0835143A1Jun 5, 1996Apr 15, 1998Reprogenesis, Inc.Injectable hydrogel compositionsEP0845480B1Nov 27, 1997May 2, 2003Kuraray Co., Ltd.Polyvinyl alcohol hydrogel and process for producing the sameEP0927053B1Aug 14, 1997Apr 2, 2003Fusion Medical Technologies, Inc.Fragmented polymeric hydrogels for adhesion prevention and their preparationEP1079224B1Aug 17, 2000May 9, 2007Wardlaw, Stephen ClarkMethod and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sampleEP1174463A1Feb 18, 2000Jan 23, 2002Denki Kagaku Kogyo Kabushiki KaishaHyaluronic acid gel composition, process for producing the same, and medical material containing the sameEP1593400A1Apr 25, 2005Nov 9, 2005Depuy Products, Inc.Hybrid biologic-synthetic bioabsorbable scaffoldsEP1595899B1Jan 7, 2004Nov 25, 2009Kawamura Institute Of Chemical ResearchPolymer gel containing biocompatible material, dry gel, and process for producing polymer gelFR2786400B1 Title not availableFR2865939B1 Title not availableFR2866571B1 Title not availableGB2338958A Title not availableJP10036524A Title not availableJP10036534A Title not availableJP10043286A Title not availableWO2090/15082A1 Title not availableWO2004007651A1Jul 16, 2002Jan 22, 2004Huntsman Spec Chem CorpHydraulic and gear lubricantsWO2004029174A1Sep 18, 2003Apr 8, 2004Basf AgPolymerized hydrogel adhesives with high levels of monomer units in salt formWO2004031253A1 *Oct 2, 2003Apr 15, 2004Coloplast AsA hydrogelWO2004047690A8Nov 25, 2003Oct 21, 2004Allison C BainProsthetic spinal disc nucleus with elevated swelling rateWO2004055057A1Dec 17, 2003Jul 1, 2004Alan Yik Lum KwokHydrogel preparation and process of manufacture thereofWO2004060427A1Nov 18, 2003Jul 22, 2004Kimberly Clark CoLubricious coating for medical devicesWO2004063388A3Jan 9, 2004Sep 1, 2005Cleveland Clinic FoundationHydroxyphenyl cross-linked macromolecular network and applications thereofWO2004064693A1Jan 16, 2003Aug 5, 2004Replication Medical IncHydrogel-based prosthetic device for replacing at least a part of the nucleus of a spinal discWO2004066704A3Dec 4, 2003Dec 8, 2005Cornell Res Foundation IncInjectable hydrogel microspheres from aqueous two-phase systemWO2004069296A1Feb 2, 2004Aug 19, 2004Ct Pulse Biolog IncHydrogel compositions comprising nucleus pulposus tissueWO2004072138A1Jan 7, 2004Aug 26, 2004Kazutoshi HaraguchiPolymer gel containing biocompatible material, dry gel, and process for producing polymer gelWO2004093786A3Apr 14, 2004Mar 23, 2006Corium IntCovalent and non-covalent crosslinking of hydrophilic polymers and adhesive compositions prepared therewithWO2007067697A2Dec 7, 2006Jun 14, 2007Zimmer IncMethods of bonding or modifying hydrogels using irradiationWO2009020793A2Jul 29, 2008Feb 12, 2009Zimmer IncMulti-polymer hydrogels* Cited by examinerNon-Patent CitationsReference1"Glossary of Basic Terms in Polymer Science," published by the International Union of Pure and Applied Chemistry, Pure Appl. Chem. 68, 2287-2311 (1996 IUPAC), Great Britain.2"Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry," Spring 2003, 8 pages.3Anseth, Kristi, et al., "In situ Forming degradable networks and their applications in tissue engineering and drug delivery", Journal of Controlled Release, vol. 78, pp. 199-209, 2002.4Babb D.A., et al., Perfluorocycleobutaine Aromatic Ether Polymers. III. Synthesis and Thermal Stability of a Thermoset Polymer Containing Triphenylphosphine Oxide, Journal of Applied Polymer Science, vol. 69 (1998), pp. 2005-2012, John Wiley and Sons Inc.5Bass, Lawrence, et al., "Laser Tissue Welding: A comprehensive Review of Current and Future Clinic Applications", Lasers in Surgery and Medicine, vol. 17, pp. 315-349, 1995.6Bray, J.C. et al. "Poly(vinyl Alcohol) Hydrogels for Synthetic Articular Cartilage Material," Biomed. Mater. Res., vol. 7, pp. 431-443, 1973.7Bray, J.C. et al. "Poly(vinyl Alcohool) Hydrogels: Formation by Eelctron Beam Irradiation of Aqueous Solutions and Subsequent Crystallization." J. Applied Polymer Sci., vol. 17, pp. 3779-3794, 1973.8Bryant, S.J. et al. "Crosslinking Density Influences Chrondrocyte Metabolism in Dynamically Leaded Photocrosslinked Poly(ethylene glycol) Hydrogels." Ann. Biomed. Eng., Mar. 2004, pp. 407-417, vol. 3, No. 3.9Bryant, S.J. et al. "Photocrosslinkable Poly(ethylene oxide) and Poly (vinyl alcohol) Hydrogels for Tissue Engineering Cartilage." 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society, Oct. 13-15, 1999, Atlanta, GA; Engineering in Medicine and Biology 1999, p. 751, vol. 2.10Bryant, S.J. et al. "The Effects if Scaffold thickness on Tissue Engineered Cartilage in Photocrosslinked Poly (ethylene oxide) hydrogels." Biomaterials 22, 2001, pp. 619-628.11Carey, F., et al., "Advanced Organic Chemistry, Part B: Reactions and Synthesis", Plenum Publishers, NY, 4th Edition, 2001 pp. 829.12Carey, F., et al., "Advanced Organic Chemistry, Part B: Reactions and Synthesis", Plenum Publishers, NY, p. 829, (2001).13Chow, L., et al., "Monographs in Oral Science", Karger, 2001, vol. 18, pp. 94-111-"Solubility of Calcium Phosphates" and pp. 130-147-"Amorphous Calcium Phosphate".14Chow, L., et al., "Monographs in Oral Science", Karger, 2001, vol. 18, pp. 94-111—"Solubility of Calcium Phosphates" and pp. 130-147—"Amorphous Calcium Phosphate".15Chow, LC, et al., "Octacalcium Phosphate" Monograph in Oral Science, Krager, 2001, vol. 18, "Solubility of Calcium Phosphates" pp. 94-112 and "Amorphous Calcium Phosphate" pp. 130-148.16Covert, R.J. et al. "Friction and Wear Testing of a New Biomaterial for Use as an Articular Cartilage Substitute," BED 50 (2001), 355-356, Bioengineering Conference, ASME 2001.17Ding, Mei Yee. Characterisation of Polyvinyl Alcohol Hydrogels, 2003. Undergraduate Chemical Engineering Thesis, University of Queensland, Brisbane QLD 4072, Australia http://www.cheque.uq.edu.au/ugrad/theses/2003/pdf/CHEE4006/40054522/40054522.pdf (working link on Apr. 20, 2009).18Durmaz, S. et al. "Phase Separation during the Formation of Poly(acrylamide) Hydrogels" Polymer 41, 2000, pp. 5729-5735.19EP Search Report for EP Application No. 050010009.9-2115, dated Mar. 1, 2005.20EP Search Report for EP Application No. 06255568.5 dated Jun. 5, 2007.21EP Search Report for EP Application No. 06256452.1 dated May 23, 2007.22EP Search Report for EP Application No. 06256525.4 dated May 10, 2007.23European Patent Office, European Search Report issued in corresponding European Patent Application Serial No. EP 06256525.4, dated May 10, 2007 (3 pages).24Gong, J.P. et al. "Friction of Polymer Gels and the Potential Application as Artificial Cartilage." SPIE, Mar. 1999, pp. 218-225, vol. 3669.25Green et al. Organic Chemistry Principles and Industrial Practice. Wiley VCH, 2003.26Guilherme, R. et al. "Hydrogels based on PAAm network with PNIPAAm included: hydrophilic-hydrophobic transition measured by the partition of Organe II and Methylene Blue in Water." Polymer 44, 2003, pp. 4213-4219.27Haralabakopoulus et al. J. Appl. Poly. Sci., 69, 1885-1890 (1998).28Hassan, C.M. et al. "Modeling of Crystal Dissolution of Poly(vinyl alcohol) gels produced by freezing/thawing processes." Polymer 41, 2000, pp. 6729-6739.29Hassan, C.M. et al. "Structure and Morphology of Freeze/Thawed PVA Hydrogels," Macromolecules, 2000, pp. 2472-2479, vol. 33, No. 7.30Hassan, Christie, et al, "Cellular PVA Hydrogels Produced by Freeze/Thawing," Journal of Applied Polymer Science, vol. 76, pp. 2075-2079, 2000.31Hassan, Christie, et al, "Diffusional characteristics of freeze/thawed poly(vinyl alcohol) hydrogels: Applications to protein controlled release from multilaminate devices," European Journal of Pharmaceutics and Biopharmeceutics, vol. 49, pp. 161-165. 2000.32Hassan, et al., Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods, Advances in Polymer Science, vol. 153, Springer-Verlag Berlin Heidelberg 2000.33Hickey, "Journal of Membrane Science", "Mesh size and diffusive characteristics of semicrystalline poly (vinyl alcohol) membranes prepared by freezing/thawing techniques", vol. 107. 1995, pp. 229-237.34Hickey, A.S. et al. "Solute Diffusion in Poly(vinyl) alcohol/poly(acrylic) acid composite membranes prepared by freezing/thawing techniques." J. Memb. Sci. 107, 1995, pp. 229-237.35Hickey, Alla, et al, "Solute diffusion in poly(vinyl alcohol)/poly(acrylic acid) composition membrances prepared by freezing/thawing techniques," Polymer, vol. 38, No. 24, pp. 5931-5936, 1997.36International Preliminary Report on Patentability for PCT/US2008/071539 dated Mar. 2, 2010.37International Search Report and Written Opinion for PCT/US2006/046725 dated Jul. 28, 2008, 20 pgs.38International Search Report and Written Opinion for PCT/US2007/064782 dated May 30, 2008.39International Search Report and Written Opinion for PCT/US2008/083213 dated May 8, 2009.40International Search Report for PCT/US2008/071435 dated Feb. 12, 2009.41Invitation to Pay Additional Fees and Annex to Search Report for PCT/US2006/04672 dated Apr. 22, 2008, 8 pages.42IPRP from PCT/US2008/071435, Feb. 9, 2010.43IPRP from PCT/US2008/071539, Mar. 2, 2010.44ISR/WO for PCT/US2006/006356 dated Jun. 22, 2006, 9 pages.45Jaguar-Grodzinski, J. "Biomedical Application of Functional Polymers." Reactive and Functional Polymers 39 (1999) 99-138.46Jagur-Grodzinski in Reactive and Functional Polymers, 39, 99-139 (1999).47Kawanishi, K. Thermodynamic Consideration of the Sol-Gel Transition in Polymer Solutions. 35th Annual Meeting of the Society of Polymer Science, Japan 1986.48Kobayashi, M. et al. "Development of An Artificial Meniscus Using Polyvinyl alcohol-hydrogel for early return to, and continuance of, athletic life in sportspersons with severe meniscus injury." Abstract only, The Knee 10, 2003, p. 53.49Kobayashi, M. et al. "Preliminary Study of Polyvinylalcohol-hydrogel (PVA-H) artificial meniscus." Biomaterials 24, 2003, pp. 639-647.50Lee et al. "Synthesis and Optical Properties of Sol-Gel Hybrid Materials that Contain Perfluorocyclobutyl Groups." Macromol. Rapid Comm., vol. 27, Issue 16, 2006, pp. 1330-1313.51LeGeros, R., "Calcium Phosphates in Oral Biology and Medicine" Monograph in Oral Science, Karger, 1991, vol. 15, pp. 1-201.52LeGeros, R., "Monographs in Oral Science", "Calcium Phosphates in Oral Biology and Medicine", vol. 15, Karger Publishers, 1991, pp. 1-201.53Lester, C.L. et al. "Physical Properties of Hydrogels Synthesized from Lyotropic Liquid Crystalline Templates" Chem. Mater. 15, 2003, pp. 3376-3384.54Li, Bin, et al, "Synthesis of a Self-Gelatinizable Grafting Copolymer of Poly(vinyl Alcohol) for construction of an Amperometric Peroxidase Electrode," Analytical Biochemistry, vol. 256, pp. 130-132, 1998.55Lin-Gibson, Sheng, et al, "Synthesis and Characterization of PEG Dimethacrylates and Their Hydrogels "Biomacromolecules, vol. 5, pp. 1280-1287, 2004.56 *Liu et al., "Triarylamine-Containing Poly(perfluorocyclobutane) as Hole-Transporting Material for Polymer Light-Emitting Diodes," in Macromolecules 2000, 33, 3514-3517.57Lozinsky, V.I. "On the Possibility of Mechanodestruction of Poly (vinyl Alcohol) Molecules under Moderate Freezing of its Concentrated Water Solutions." Polymer Bulletin, 15, p. 333-340 (1986).58Lozinsky, V.I. et al. "Study of Cryostructuration of Polymer Systems, XVII. Poly(vinyl alcohol) Cryogels: Dynamics of the Cryotropic Gel Formation." J. Appl. Polymer Sci., vol. 77, 2017-2023 (2000).59Lozinsky, V.I. et al. "Study of Cryostructures of Polymer Systems, XIV. Poly(vinyl alchohol) Cryogels: Apparent Yield of Freeze-Thaw Induced Gelation of Concentrated Aqueous Solutions of the Polymer." J. Applied Polymer Sci., vol. 77, 1822,1831 (2000).60Lozinsky, V.I. et al. "Swelling Behavior of poly (vinyl alcohol) cryogels employed as matrices for cell immobilization." Enzyme Microb. Tehnol., vol. 18, pp. 561-509, 1996.61Lozinsky, Vladimer,. et al. "Study of Cryostructuration of Polymer Systems. XVII. Poly(vinyl alcohol) Cryogels:Dynamics of the Cryotropic Gel Formation," Journal of Applied Polymer Science, vol. 77, pp. 2017-2023, 2000.62Lu et al. Journal of Controlled Release, 57, 291-300 (1999).63Mano, V. et al. "Blends Composed of Poly(N-Isopropylacrylamide) and an Ethylene/Vinyl Alcohol Copolymer: Thermal and Morphological Studies" J. App. Polymer Sci., 2004, pp. 501-505.64Mondino et al. Rad. Chem. and Phys. 55, 723-726 (1999).65Mondino, A.V. et al. "Physical properties of gamma irradiated poly (vinyl alcohol) hydrogel preparations" Radiation Physics and chemistry, 55, p. 723,726 (1999).66Moro, Toru, et al, "Surface Grafting of artifical joints with a biocompatible polymer for preventing periprosthetic osteolysis", Nature Materials, vol. 3, pp. 829-836, 2004.67Noguchi, et al., Poly(vinyl Alcohol) Hydrogel As an Artificial Articular Cartilage: Evaluation of Biocompatibility, Journal of Applied Biomaterials, vol. 2 101-107 (1991), 1991 John Wiley & Sons, Inc.68Office Action for EP Application No. 06256525.4 dated Nov. 12, 2009.69Office Action for EP Application No. EP 06 256525.4 dated Jun. 24, 2008.70Office Action for EPApplication No. 06256525.4 dated Apr. 27, 2010.71Office Action from EP 06256525.4, Apr. 15, 2009.72Oka, M., et al, "Development of artificial articular cartilage", Proc Inst. Mech. Engrs, vol. 214, Part H, pp. 59-68, 2000.73Park, J.H. et al. "Hydrogels based on Poly(ethylene oxide) and poly (tetramethylene oxide) or poly)dimethyl siloxane). III. In vivo Biocompatability and Biostability." J. Biomed. Mater. Res. 64A, 2003, pp. 309-319.74Park, Kyoung Ran, et al, "Synthesis of PVA/PVP hydrogels having two-layer by radiation and their physical properties," Radiation Physics and Chemistry, vol. 67, pp. 361-365, 2003.75PCT International Preliminary Report on Patentability for PCT/US2008/071435 dated Feb. 9, 2010.76Peppas et al. "Reinforced Uncrosslinkable Poly (vinyl alcohol) gels produced by cyclic freezing-thawing processes: A Short Review." J. Controlled Release, 16 (1991), 305-310.77Peppas, et al., Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology, Annu. Rev. Biomed. Eng. 2000, 02:9-29.78Peppas, N. A., et al, "Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology", Annuls Rev Biomedical Engrs., 02: Sep. 20, 2000.79Preliminary Examination Report and Search Report for PCT/EP2005/010931 dated Feb. 6, 2007.80Preliminary Report on Patentability and Written Opinion for PCT/US2006/006356 dated Aug. 28, 2007.81Rao, Linfeng, et al, "Complexation of Eu(III) with alkyl-substituted malonamides in acctonitrile," Journal of Chemical Society, pp. 1939-1944, 2001.82Rosiak, J.M., et al., "Synthesis of Hydrogels by irradiation of polymers in aqueous solution" Radiation Physics and Chemistry, vol. 55, pp. 139-151, 1999.83Schmedlen, R.H. et al. "Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering." Biomaterials, 23, 2002, pp. 4325-4332.84 *Smith Jr. et al., "Perfluorocyclobutane (PFCB) polyaryl ethers: versatile coatings materials," in Journal of Fluorine Chemistry 104 (2000), 109-117.85Stammen, J.A., et al, "Mechanical properties of a novel PVA hydrogel in shear and unconfined compression", Biomaterials, pp. 799-806 abstract only, 2001.86Suggs, L.J. et al. "In vitro Cytotoxicity and In Vivo Biocompatability of Poly(propylene fumurate-co-ethylene glycol) hydrogels." J. Biomed. Mater. Res., 1999, pp. 22-32, vol. 46.87Taguchi. Chemistry Letters, 711-712 (1998).88Thomas, J.D. "Novel Associated PVA/PVDP Hydrogels for Nucleuc Pulposus Replacement." Thesis, Master of Science in Material Engineering Degree, Drexel University, Sep. 2001.89Transmittal of International Preliminary Report on Patentability for PCT/US2008/086817 dated Jul. 6, 2010.90Tripathy et al. "Novel Flocculating Agent Based on Sodium Alginate and Acrylamide." European Polymer Journal. 35, 2057-2072 (1999).91Ulanski, P. et al. "OH-Radical induced crosslinking and strand breakage of poly (vinyl alcohol) in aqueous solution in the absence and presence of oxygen. A pulse radiolysis and product study" Macromol. Chem. Phys. 195, p. 1443-14461 (1994).92Urushizaki, F. Swelling and Mechanical Properties of Poly (vinyl alcohol) Hydrogels. Intl. J. Pharma., 58, 135-142, 1990.93Ushio, K. et al. "Attachment of Artificial Cartilage to Underlying Bone." J. Biomed. Mater. Res. Part B: Appl. Biomater. 68B, 2004, pp. 59-68.94Ushio, K. et al. "Partial Hemiarthroplasty for the treatment of Osteonecrosis of the Femoral Head: An Experimental Study in the Dog." J. Bone Joint Surg., 2003, pp. 922-930, vol. 85B.95Wang, Benlian, et al, "The influence of polymer concentration on the radiation-chemical yield of intermolecular crosslinking of poly(vinyl alcohol) by y-rays in deoxygenated aqueous solution", Radiation Physics and Chemistry, vol. 59 pp. 91-95, 2000.96West et al. Reactive Polymers, 139-147 (1995).97 *Wong et al., "Perfluorocyclobutane-Based Polyester(arylene ether)s for Applications in integrated Optics," in Macromolecules 2004, 37, 5578-5585.98Yamaura, Kazuo, et al, "Properties of Gels Obtained by Freezing/Thawing of Poly(vinyl Alcohol)/Water/Dimethyl Sulfoxide Solutions," Journal of Applied Polymer Science, vol. 37 pp. 2709-2718, 1989.99Yokoyama, F. "Morphology and Structure of Highly Elastic Poly (vinyl alcohol) Hydrogel Prepared by Repeated Freezing-and-Melting" Colloid & Polymer Sci. 264, 595-601 (1986).100Zhang, X. et al. "Synthesis and Characterization of Partially Biodegradable, Temperature and pH Sensitive Dex-MA/PNIPAAm Hydrogels." Biomat., 25, 2004, pp. 4719-4730.* Cited by examinerClassifications U.S. Classification424/70.11, 525/199, 424/78.37International ClassificationA61K31/765, A61K8/72, C08L27/12Cooperative ClassificationA61K8/8176, A61K8/042, A61F2230/0069, A61F2/40, A61F2002/30075, A61F2/38, A61L27/52, A61K8/8158, A61K8/8135, A61F2/4241, A61F2230/0008, A61F2/44, A61K8/8152, A61F2/3804, A61F2/32, A61F2002/30224, A61F2002/30125, A61F2/4261, A61K8/84, A61L27/34, A61K8/8147, A61K2800/57, A61F2210/0061, A61Q11/00, A61F2/4202European ClassificationA61L27/52, A61K8/81K2, A61K8/81R2, A61K8/81K6, A61K8/84, A61K8/04A, A61K8/81K4, A61Q11/00, A61K8/81H, A61L27/34Legal EventsDateCodeEventDescriptionJan 16, 2007ASAssignmentOwner name: ZIMMER, INC., INDIANAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:THOMAS, BRIAN;ZHANG, KAI;REEL/FRAME:018760/0941Effective date: 20061221Feb 25, 2015FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services