Source: https://patents.google.com/patent/US5607457?oq=flatulence
Timestamp: 2018-03-18 19:46:03
Document Index: 370832181

Matched Legal Cases: ['art 4', 'art 4', 'art 4', 'art 4', 'art 4', 'art.\n2']

US5607457A - Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes - Google Patents
Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes
US5607457A
US5607457A US08536453 US53645395A US5607457A US 5607457 A US5607457 A US 5607457A US 08536453 US08536453 US 08536453 US 53645395 A US53645395 A US 53645395A US 5607457 A US5607457 A US 5607457A
US08536453
A heart stimulator, operable for single-chamber and/or dual-chamber pacing, includes first and second electrical leads connected to a pulse generator and each terminating in an electrode, the electrodes being disposed respectively in the atrium and the ventricle. A differential detector is connected to the first and second leads and detects cardiac activity between the atrial electrode and the ventricular electrode. A correlation detector is connected between the pacemaker housing and one of the atrial or ventricular electrodes, and generates a correlation signal identifying whether the cardiac activity detected by the cardiac activity detector arose in the atrium or in the ventricle. The outputs of the differential detector and the correlation detector are supplied to a logic circuit which determines therefrom whether a stimulation pulse emitted by the pulse generator resulted in an evoked response in the heart.
It is an object of the present invention to provide a pacemaker wherein stimulation and sensing takes place using two unipolar electrodes, one electrode placed in the right atrium, and the other placed in the right ventricle, wherein sensing takes place without significant interference.
FIG. 1 illustrates the connection of a pacemaker constructed in accordance with the principles of the present invention to a heart.
FIG. 1 illustrates an implantable pacemaker 1 for stimulating and sensing cardiac activity in vivo in a (schematically illustrated) heart 4. The pacemaker 1 is in electrical connection with the heart 4 by means of a unipolar atrial lead 2 and a unipolar ventricular lead 5. The atrial lead 2 terminates in an electrode 3 disposed at a suitable location in the right atrium of the heart 4, and the ventricular lead 5 terminates in an electrode 6 disposed at a suitable location in the right ventricle of the heart 4. The respective positions of the electrodes 3 and 6 within the heart 4 shown in FIG. 1 are for exemplary purposes only; the electrodes 3 and 6 can be placed at any suitable locations respectively in the right atrium and the right ventricle in accordance with the physiology and pacing therapy associated with a particular patient. Moreover, only one lead and electrode may be used (active) i.e., only the atrial electrodes 3 or only the ventricular electrode 6, in the case of single-chamber pacing, although both leads and electrodes will still be present.
a housing implantable in a subject;
a first unipolar electrical lead electrically connected to said pulse generator means for receiving said stimulation pulses therefrom, and terminating in an atrial placeable electrode placeable in the atrium of a heart of said subject;
a second unipolar electrical lead electrically connected to said pulse generator means for receiving said stimulation pulses therefrom, and terminating in a ventricular electrode placeable in the ventricle of said heart;
control means for controlling said pulse generator means for causing said stimulation pulses to be delivered to at least one of the atrium and the ventricle;
means in said housing connected to said first and second electrical leads for differentially detecting cardiac activity between said atrial electrode and said ventricular electrode and generating an electrical cardiac activity signal corresponding to said cardiac activity;
means in said housing, connected between said housing and one of said atrial or ventricular electrodes, for generating a correlation signal identifying whether said cardiac activity detected by said means for differentially detecting cardiac activity arose in the atrium or in the ventricle; and
logic means, supplied with said cardiac activity signal and said correlation signal, for determining from said cardiac activity signal and said correlation signal whether a stimulation pulse emitted by said pulse generator means resulted in an evoked response in said heart.
2. A heart stimulator as claimed in claim 1 further comprising switching means for selectively connecting said means for generating a correlation signal between said housing and said atrial electrode or between said housing and said ventricular electrode.
3. A heart stimulator as claimed in claim 1 wherein said means for differentially detecting cardiac activity comprises:
editing means having a first input connected to said first electrical lead and a second input connected to said second electrical lead for producing an edited signal from a signal across said first and second inputs;
signal converter means for converting said edited signal into a converted signal having a characteristic associated therewith which changes dependent on whether an evoked response has resulted following emission of a stimulation pulse by said pulse generator means;
comparator means for comparing said characteristic to a predetermined threshold and emitting an output signal dependent on a value of said characteristic relative to said threshold, said output signal comprising said cardiac activity signal.
4. A heart stimulator as claimed in claim 3 wherein said editing means includes means for filtering said signal across said first and second inputs.
9. A heart stimulator as claimed in claim 1 wherein said means for detecting cardiac activity comprises:
first signal converter means for converting said edited signal into a first converted signal, having a first parameter which changes dependent on whether an evoked response resulted following emission of a stimulation pulse by said pulse generator means;
first comparator means for comparing said first characteristic to a first threshold and for emitting a first output signal dependent on a value of said first characteristic relative to said first threshold;
second signal converter means for converting said edited signal into a second converted signal, having a second characteristic, different from said first characteristic, which changes dependent on whether an evoked response resulted following emission of a stimulation pulse by said pulse generator means;
second comparator means for comparing said second characteristic to a second threshold and for emitting a second output signal dependent on a value of said second characteristic relative to said second threshold; and
detection logic means, supplied with said first and second output signals, for generating said cardiac activity signal dependent on said first and second output signals.
10. A heart stimulator as claimed in claim 9 wherein said editing means includes means for filtering said signal across said first and second inputs.
15. A heart stimulator as claimed in claim 1 wherein said means for generating a correlation signal comprises:
editing means having a first input connected to one of said first or second electrical leads and a second input connected to said housing for producing an edited signal from a signal across said first and second inputs;
comparator means for comparing said characteristic to a predetermined threshold and emitting an output signal dependent on a value of said characteristic relative to said threshold, said output signal comprising said correlation.
16. A heart stimulator as claimed in claim 15 wherein said editing means includes means for filtering said signal across said first and second inputs.
21. A heart stimulator as claimed in claim 1 wherein said means for generating a correlation signal comprises:
editing means having a first input connected to one of said first or second electrical leads and a second input connected to said housing for producing an edited signal from said first and second inputs;
detection logic means, supplied with said first and second output signals, for generating said correlation signal dependent on said first and second output signals.
22. A heart stimulator as claimed in claim 21 wherein said editing means includes means for filtering said signal across said first and second inputs.
US08536453 1995-09-29 1995-09-29 Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes Expired - Fee Related US5607457A (en)
US08536453 US5607457A (en) 1995-09-29 1995-09-29 Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes
EP19960114274 EP0765672B1 (en) 1995-09-29 1996-09-06 Heart stimulator with evoked response detection
DE1996632673 DE69632673D1 (en) 1995-09-29 1996-09-06 Pacemaker with evoked response detection
DE1996632673 DE69632673T2 (en) 1995-09-29 1996-09-06 Pacemaker with evoked response detection
JP25673496A JPH09103503A (en) 1995-09-29 1996-09-27 Induced reaction detecting type heart stimulating device
US5607457A true US5607457A (en) 1997-03-04
ID=24138558
US08536453 Expired - Fee Related US5607457A (en) 1995-09-29 1995-09-29 Pacemaker with evoked response detection by using differential sensing between two unipolar electrodes
US (1) US5607457A (en)
JP (1) JPH09103503A (en)
DE (2) DE69632673T2 (en)
EP (1) EP0765672B1 (en)
EP0882469A3 (en) * 1997-06-06 2000-01-05 Pacesetter AB Implatable heart stimulator
EP0765672A3 (en) 1998-10-28 application
DE69632673T2 (en) 2005-06-09 grant
EP0765672A2 (en) 1997-04-02 application
JPH09103503A (en) 1997-04-22 application
EP0765672B1 (en) 2004-06-09 grant
DE69632673D1 (en) 2004-07-15 grant
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SCHULLER, HANS;REEL/FRAME:007784/0482