Source: https://patents.google.com/patent/EP1198299B1/en
Timestamp: 2020-07-09 23:32:56
Document Index: 73653974

Matched Legal Cases: ['art 1', 'arts 7', 'art 1', 'art 1', 'arts 7', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 7', 'art 1', 'art 7', 'art 1', 'art 1', 'art 1', 'art 7', 'art 1', 'art 53', 'art 1', 'art 1', 'art 53', 'art 1', 'art 7', 'art 1', 'art 1', 'art 53', 'art 53', 'art 1', 'art 1', 'art 1', 'art 1', 'art 9']

EP1198299B1 - Delivery device - Google Patents
EP1198299B1
EP1198299B1 EP00948463A EP00948463A EP1198299B1 EP 1198299 B1 EP1198299 B1 EP 1198299B1 EP 00948463 A EP00948463 A EP 00948463A EP 00948463 A EP00948463 A EP 00948463A EP 1198299 B1 EP1198299 B1 EP 1198299B1
EP00948463A
EP1198299A1 (en
Bruce Macmichael
1999-07-12 Priority to SE9902672 priority Critical
1999-07-12 Priority to SE9902672A priority patent/SE9902672D0/en
2000-07-07 Application filed by AstraZeneca AB filed Critical AstraZeneca AB
2000-07-07 Priority to PCT/SE2000/001470 priority patent/WO2001003851A1/en
2002-04-24 Publication of EP1198299A1 publication Critical patent/EP1198299A1/en
2008-07-16 Publication of EP1198299B1 publication Critical patent/EP1198299B1/en
A manually-actuated delivery device for the delivery of a volume of liquid, comprising: a housing which includes an outlet (27) through which liquid is in use delivered; and a cover member (39) which is movably disposed relative to the housing between a first position in which the cover member (39) at least partly covers the outlet (27) and a second position in which the cover member (39) acts as a lever which in use is acted upon by a user to actuate the delivery device. The delivery device comprises furthermore an indicator that indicates the number of actuations of the delivery device. Means for locking the delivery device in order to prevent further action of the delivery device once the delivery device has been actuated a predetermined number of times are also provided.
US-A-5 465 873 discloses a delivery device corresponding to the preamble of claim 1 which, in use, is acted upon by a user to actuate the delivery device, whereby the force applied by the user to a lever is substantially orthogonal to and in a direction away from the axis of the delivered liquid. The delivery device of US-A-5 465 873 is not ergonomically suitable for single handed use.
US-A-4 949 875 discloses a delivery device which in use is acted upon by a user to actuate the delivery device, wherein the force applied by the user to a lever is substantially in parallel with, and not in a direction towards the axis of the delivered liquid.
Accordingly, the present invention provides a manually-actuated delivery device for the delivery of a volume of liquid, comprising the features set forth in claim 1, as well as an inhalation device incorporating said delivery device, as set forth in claim 24.
According to the invention as defined in claim 1, the delivery device further comprises a liquid delivery assembly which includes a liquid delivery unit which is configured to be actuated to deliver a volume of liquid to the outlet on actuation of the delivery device, and a coupling member which is movably disposed to the housing and configured to be engaged by the cover member in the second position thereof and cause actuation of the liquid delivery unit when the cover member is acted upon by the user.
Still more preferably, the liquid delivery assembly includes at least one projection and the coupling member includes at least one arm which is configured in use to engage the at least one projection to move the liquid delivery assembly between the first and second positions.
More preferably the axes of rotation of the cover member and the coupling member are parallel.
As mentioned earlier, the present invention also extends to inhalation devices incorporating the above-described delivery devices.
Figures 1 and 2 illustrate respectively front and rear perspective views of a delivery device in accordance with a preferred embodiment of the present invention;
Figures 3 to 5 illustrate side views of the delivery device;
Figure 6 illustrates an exploded front perspective view of the delivery device;
Figure 7 illustrates an exploded rear perspective view of the delivery device;
Figure 8 illustrates in enlarged scale a fragmentary side view of the dose indicator of the delivery device;
Figures 9 and 10 illustrate vertical sectional views (along sections I-I and II-II in Figures 3 and 4 respectively) of the delivery device in the closed configuration;
Figures 11 and 12 illustrate vertical sectional views (along sections I-I and II-II in Figures 3 and 4 respectively) of the delivery device in the open, but non-actuated configuration; and
Figures 13 and 14 illustrate vertical sectional views (along sections I-I and II-II in Figures 3 and 4 respectively) of the delivery device in the open and actuated configuration.
The delivery device comprises a main body part 1, in this embodiment a generally cylindrical tubular section, which includes first and second open ends 3, 5, and first and second end body parts 7, 9 which are attached to the main body part 1 so as to enclose the open ends 3, 5 thereof and define an enclosed housing. In this embodiment the main body part 1 and the first and second end body parts 7,9 are formed of a plastics material and joined by a plastics weld, for example, as achieved by ultrasonic welding.
The main body part 1 includes a first lateral opening 11, in this embodiment of substantially square shape, at the first end 3, one side of which first lateral opening 11 is open at the first end 3 and the adjacent sides of which extend substantially parallel to the longitudinal axis of the main body part 1. The main body part 1 further includes first and second lugs 15, 17 which are located at respective ones of the longitudinally-extending sides of the first lateral opening 11 and extend outwardly and upwardly of the first end 3. Each of the first and second lugs 15, 17 includes a part-cylindrical bearing surface 15a, 17a for hingeably supporting a yoke member 51 as will be described further hereinbelow. The main body part 1 still further includes a second lateral opening 22 adjacent the second end 5 which acts as a window for viewing a dose indicator 95 as will be described further hereinbelow. The main body part 1 yet further includes on the inner surface thereof a plurality of longitudinally-extending elongate slots 23 for receiving correspondingly-configured ribs 83 on a carrier unit 63 disposed therewithin as will be described further hereinbelow. The main body part 1 yet still further includes on the inner surface thereof a radially-directed flange 24 which acts as an abutment for the upper edge of a ring element 97 of the dose indicator 95.
The first end body part 7 comprises a substantially planar wall member 25 which is of the same dimension as the first end 3 of the main body part 1 so as to close the same when attached thereto and a tubular section 26 which extends outwardly from the plane of the wall member 25 so as to provide a nosepiece and includes a spray orifice 27 at the distal end thereof through which a spray of liquid is in use ejected. In this embodiment the tubular section 26 is slightly inwardly tapered away from the wall member 25 and includes a rounded distal end so as to provide for ease of insertion into a nasal cavity and comfort of fit when so inserted. The first end body part 7 further includes first and second lugs 29, 31 which extend outwardly from the periphery of the wall member 25 in such a configuration as to mate with the respective ones of the first and second lugs 15, 17 on the main body part 1. Each of the first and second lugs 29, 31 includes a part-bearing surface 29a, 31a, in this embodiment part-cylindrical in section, which part-bearing surfaces 29a, 31a together with the respective part-bearing surfaces 15a, 17a provided by the lugs 15, 17 on the main body part 1 define first and second bearings which provide a hinge axis.
The delivery device further comprises.a cover member 39 for covering the tubular section 26 which provides the nosepiece. The cover member 39 comprises first and second side wall members 40, 41, in this embodiment of generally triangular shape, which are configured to be disposed adjacent opposed sides of the tubular section 26 in the closed position of the cover member 39, and an interconnecting wall member 43 which interconnects the first and second side wall members 40, 41. The side wall members 40, 41 each include an opposed projection 45, 47 on the inwardly-directed surface thereof about which the cover member 39 is hingeable. The opposed projections 45, 47 are disposed such as to be located in the first and second bearings provided by the part-bearing surfaces 15a, 17a defined by the lugs 15, 17 on the main body part 1 and the part-bearing surfaces 29a, 31a defined by the lugs 29, 31 on the first end body part 7.
The delivery device further comprises a yoke member 51 which is pivotally mounted relative to the main body part 1. The yoke member 51 comprises a body part 53 which extends through the first lateral opening 11 in the main body part 1 and includes a surface 54 at the first lateral opening 11 which acts as a bearing surface and first and second laterally-spaced arms 55, 57 which are disposed in the main body part 1 and each include a bearing surface 55a, 57a at an upper surface thereof. The body part 53 further includes first and second oppositely-directed projections 59, 61 which are disposed such as to be located respectively in the first and second bearings provided by the part-bearing surfaces 15a, 17a defined by the lugs 15, 17 on the main body part 1 and the part-bearing surfaces 29a, 31 a defined by the lugs 29, 31 on the first end body part 7.
The second tubular section 75 includes first and second oppositely-directed projections 87, 89 at one, the upper, end thereof. Each of the first and second projections 87, 89 includes a part-cylindrical bearing surface 87a, 89a at the lower surface thereof which in use is engaged by the respective bearing surfaces 55a, 57a on the first and second arms 55, 57 of the yoke member 51.
The delivery device yet further comprises a dose indicator 95 for providing an indication as to the usage of the delivery device. In this embodiment the dose indicator 95 comprises a ring element 97 of rectangular section which is located about the outer surface of the first tubular section 73 of the carrier unit 63 such that the upper edge thereof abuts the radially-directed flange 24 on the inner surface of the main body part 1 and is configured such as to be rotatable thereabout in the one sense, that is, the counter-clockwise sense when viewed from above. With this configuration, a part of the outer surface of the ring element 97 is visible through the second lateral opening 22 in the main body part 1. In this embodiment the outer surface of the ring element 97 includes numerals of decreasing value for indicating the number of times the delivery device may still be actuated. In another embodiment the outer surface of the ring element 97 could be provided with numerals of increasing value for indicating the number of times the delivery device has already been actuated. Alternatively, or additionally, the ring element 97 may have a circumferential band of changing width along its length, such that the width visible is representative of the number of doses delivered or remaining. Colour changes may also be used to indicate the number of doses delivered or remaining. Such colour changes may also be applied in conjunction with the indications described hereinabove. For instance, by using numerals of different colour, or, by using a band, the colour of which changes along its length. The dose indicator 95 includes a plurality of teeth 99 disposed about the lower edge of the ring element 97 by which the dose indicator 95 is rotated about the first tubular section 73 of the carrier unit 63 through engagement with the distal end of the resilient element 81 on the carrier unit 63 on actuation of the delivery device. Each of the teeth 99 includes a first, driving surface 99a which faces in the other sense, that is, the counter-clockwise sense when viewed from below, and a second, guiding surface 99b which includes a component which faces in the one, opposite, clockwise sense. The dose indicator 95 further includes a resilient element 101 which extends inwardly and forwardly from the ring element 97 in the sense of rotation thereof, that is, the one, counter-clockwise sense when viewed from above. The resilient element 101 is configured normally to contact the outer surface of the first tubular section 73 of the carrier unit 63, but, as will be described further hereinbelow, to locate in the lateral opening 85 in the first tubular section 73 of the carrier unit 63 when the delivery device has been actuated a predetermined number of times so as to lock the carrier unit 63 in a fixed position and thereby prevent further use of the delivery device when the accuracy of the metered dose could not be ensured because of the small volume of liquid remaining in the container 67 of the liquid delivery unit 65.
In use, a user takes the delivery device in one hand and lifts the cover member 39 so as to rotate the same from the closed position (as illustrated in Figures 9 and 10) to the open position (as illustrated in Figures 11 and 12) in which the tubular section 26 providing the nosepiece is exposed for insertion into a nasal cavity. In this open position, the part of the interconnecting member 43 of the cover member 39 which is adjacent the projections 45, 47 which define the hinge axis contacts the exposed bearing surface 54 on the body part 53 of the yoke member 51 and the delivery device is ready for use. The user then inserts the nosepiece provided by the tubular section 26 into a nasal cavity and actuates the delivery device by applying a force to the cover member 39 which now acts as a lever when rotated further in the same sense as in which the cover member 39 was opened. In applying a force to the cover member 39 further to rotate the same, the yoke member 51, through engagement between the part of the interconnecting member 43 of the cover member 39 adjacent the projections 45, 47 and the bearing surface 54 of the body part 53 thereof, is rotated such that the arms 55, 57 thereof are moved upwardly. This rotation, through engagement of the arms 55, 57 of the yoke member 51 and the bearing surfaces 87a, 89a on the projections 87, 89 on the second tubular section 75 of the carrier unit 63, causes the carrier unit 63 to be slid axially upwardly within the main body part 1. This sliding movement of the carrier unit 63, in which the liquid delivery unit 65 is mounted, causes the tubular delivery element 71 of the pump 69 of the liquid delivery unit 65 to be moved into the body 70 thereof and thereby force a volume of liquid through the spray orifice 27 and into the nasal cavity as a spray; the tubular delivery element 71 being of fixed position in relation to the main body part 1 in which the carrier unit 63 slides. With this actuation of the delivery device the ring element 97 of the dose indicator 95 is rotated by engagement of the distal end of the resilient element 81 on the carrier unit 63 against the driving surface 99a of one of the teeth 99 on the lower edge of the ring element 97. This advancement of the ring element 97 causes a lower number to be visible through the second lateral opening 22 in the main body part 1, which number is in this embodiment representative of the number of doses remaining. After actuation of the delivery device the user then releases the actuation force applied to the cover member 39 and the carrier unit 63 is forced to slide axially downwardly, through the force of an internal resilient element in the pump 69, within the main body part 1 such as to return to the original position. At the same time, the yoke member 51 is also rotated back to the original position through the engagement of the projections 87, 89 on the second tubular section 75 of the carrier unit 63 and the arms 57, 59 on the yoke member 51. Further, this sliding movement of the carrier unit 63 causes the resilient element 81 thereon to disengage from the driving surface 99a of the one tooth 99; back-rotation of the ring element 97 of the dose indicator 95 being prevented by the resilient element 38 on the second end body part 9 which continuously engages the lower edge of ring element 97 such that the distal end of the resilient element 38 is always located adjacent the driving surface 99a of one of the teeth 99. The user then returns the cover member 39 to the closed position such that the spray orifice 27 in the tubular section 26 providing the nosepiece is enclosed and the delivery device is ready for further use. This operation of the delivery device can be repeated until the delivery device has been actuated a predetermined number of times, at which point the ring element 97 of the dose indicator 95 will have been rotated through such an angle that the resilient element 101 thereon is axially aligned with the opening 85 in the first tubular section 73 of the carrier unit 63 and on further actuation of the delivery device the resilient element 101 will locate in the opening 85 and lock the carrier unit 63 in a fixed position, in this embodiment the actuated position, to prevent further use of the delivery device.
Finally, it will be understood that the present invention has been described in its preferred embodiment and can be modified in many different ways if not thereby departing from the scope of the invention as defined by the appended claims.
A manually-actuated delivery device for the delivery of a volume of liquid, comprising:
a housing which includes an outlet (27) through which liquid is in use delivered ; and
a cover member (39) which is movably disposed relative to the housing between a first position in which the cover member (39) at least partly covers the outlet (27) and a second position in which the cover member (39) acts as a lever which in use is acted upon by a user to actuate the delivery device, the delivery device further comprising a liquid delivery assembly which includes a liquid delivery unit (65) which is configured to be actuated to deliver a volume of liquid to the outlet (27) on actuation of the delivery device, and a coupling member (51) which is movably disposed to the housing and configured to be engaged by the cover member (39) in the second position thereof and cause actuation of the liquid delivery unit (65) when the cover member (39) is acted upon by the user, characterised in that the force applied by the user to the lever is substantially orthogonal to the axis of the delivered liquid.
The delivery device according to claim 1, wherein the cover member (39) is, in the first position thereof, configured completely to cover the outlet (27).
The delivery device according to claim 1 or 2, wherein the cover member (39) is rotatably mounted to the housing.
The delivery device according to claim 3, wherein the liquid delivery unit(65) comprises a container (67) for containing liquid and a pump (69) for delivering a volume of liquid from the container (67) to the outlet (27).
The delivery device according to claim 4, wherein the pump (69) comprises a body (70) and a tubular element (71) element which is movable relative to the body (70) and through which a volume of liquid is in use delivered on movement thereof relative to the body (70).
The delivery device according to claim 5, wherein the liquid delivery assembly is movably disposed to the housing such as to cause actuation of the liquid delivery unit (65) when moved between first and second positions and the coupling member(51) is configured to move the liquid delivery assembly between the first and second positions when the cover member (39) is acted upon by the user.
The delivery device according to claim 6, wherein the liquid delivery assembly includes at least one projection (89,91) and the coupling member (51) includes at least one arm (55,57) which is configured in use to engage the at least one projection (89,91) to move the liquid delivery assembly between the first and second positions.
The delivery device according to claim 7, wherein the liquid delivery assembly is slideably disposed to the housing.
The delivery device according to any of claims 6 to 8, wherein the coupling member (51) is rotatably mounted to the housing.
The delivery device according to claim 9 when appendant upon claim 3, wherein the axes of rotation of the cover member (39) and the coupling member (51) are parallel.
The delivery device according to claim 10, wherein the axes of rotation of the cover member (39) and the coupling member (51) are co-axial.
The delivery device according to any of claims 4 to 11, wherein the liquid delivery assembly further includes a carrier unit (63) to which the liquid delivery unit (65) is attached.
An inhalation device incorporating the delivery device according to any of claims I to 12.
A delivery device, according to any of Claims 4 to 13, wherein the liquid delivery unit (65) includes a component (63) which is moved on actuation thereof; and
an indicator is provided to indicate the number of actuations of the delivery unit (65), which indicator includes a rotatable member(95) which is configured to be rotated by actuation of the delivery unit (65);
wherein the rotatable member(95) includes one of a resiliently-biased element (101) or a locking surface and the component (63) includes the other of the resiliently biased element (101) or locking surface, which resiliently-biased element (101) and locking surface are configured such that the component (63) is locked in position so as to prevent further actuation of the delivery unit (65) unit once the delivery unit (65) has been actuated a predetenninable number of times.
The delivery device according to claim 14, wherein the rotatable member (95) is configured to be rotated on each actuation of the delivery unit (65).
The delivery device according to claim 14 or 15, wherein the component (63) is configured so as to move substantially parallel to the axis of rotation of the rotatable member (95).
The delivery device according to any of claims 14 to 16, wherein the component (63) is reciprocally movable.
The delivery device according to any of claims 14 to 17, wherein the rotatable member (95) includes the resiliently-biased element (101) and the component (63) includes the locking surface.
The delivery device according to any of claims 14 to 18, wherein the locking surface is provided by an opening (85).
The delivery device according to claim 19, wherein the opening (85) is a through opening.
The delivery device according to any of claims 14 to 20, wherein the rotatable member (95) is disposed about the component (63).
The delivery device according to claim 21, wherein the rotatable member (95) is disposed about an outer surface of the component (63).
The delivery device according to claim 22, wherein the outer surface of the component (63) is cylindrical and the rotatable member (95) is circular.
An inhalation device incorporating the delivery device according to any of claims 14 to 23.
EP00948463A 1999-07-12 2000-07-07 Delivery device Expired - Fee Related EP1198299B1 (en)
SE9902672 1999-07-12
SE9902672A SE9902672D0 (en) 1999-07-12 1999-07-12 Delivery device
PCT/SE2000/001470 WO2001003851A1 (en) 1999-07-12 2000-07-07 Delivery device
SI200031004T SI1198299T1 (en) 1999-07-12 2000-07-07 Delivery device
CY20081100987T CY1109009T1 (en) 1999-07-12 2008-09-15 dispenser
EP1198299A1 EP1198299A1 (en) 2002-04-24
EP1198299B1 true EP1198299B1 (en) 2008-07-16
ID=20416476
EP00948463A Expired - Fee Related EP1198299B1 (en) 1999-07-12 2000-07-07 Delivery device
US (1) US6510847B1 (en)
EP (1) EP1198299B1 (en)
JP (1) JP4430278B2 (en)
KR (1) KR100689945B1 (en)
CN (1) CN1254315C (en)
AT (1) AT401135T (en)
AU (1) AU775282B2 (en)
BR (1) BR0012421B1 (en)
CA (1) CA2378093C (en)
CY (1) CY1109009T1 (en)
DE (1) DE60039516D1 (en)
DK (1) DK1198299T3 (en)
ES (1) ES2308986T3 (en)
HK (1) HK1045474A1 (en)
IL (2) IL147215D0 (en)
MX (1) MXPA02000347A (en)
NO (1) NO20020150L (en)
NZ (1) NZ516560A (en)
PT (1) PT1198299E (en)
SE (1) SE9902672D0 (en)
SI (1) SI1198299T1 (en)
TW (1) TW500613B (en)
WO (1) WO2001003851A1 (en)
ZA (1) ZA200110531B (en)
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1999-07-12 SE SE9902672A patent/SE9902672D0/en unknown
2000-07-07 ES ES00948463T patent/ES2308986T3/en active Active
2000-07-07 EP EP00948463A patent/EP1198299B1/en not_active Expired - Fee Related
2000-07-07 WO PCT/SE2000/001470 patent/WO2001003851A1/en active IP Right Grant
2000-07-07 US US09/673,870 patent/US6510847B1/en not_active Expired - Fee Related
2000-07-07 KR KR1020027000393A patent/KR100689945B1/en not_active IP Right Cessation
2000-07-07 AU AU61944/00A patent/AU775282B2/en not_active Ceased
2000-07-07 TW TW089113474A patent/TW500613B/en not_active IP Right Cessation
2000-07-07 PT PT00948463T patent/PT1198299E/en unknown
2000-07-07 NZ NZ516560A patent/NZ516560A/en not_active IP Right Cessation
2000-07-07 CA CA002378093A patent/CA2378093C/en not_active Expired - Fee Related
2000-07-07 DE DE60039516A patent/DE60039516D1/en active Active
2000-07-07 SI SI200031004T patent/SI1198299T1/en unknown
2000-07-07 IL IL14721500A patent/IL147215D0/en active IP Right Grant
2000-07-07 MX MXPA02000347A patent/MXPA02000347A/en active IP Right Grant
2000-07-07 AT AT00948463T patent/AT401135T/en unknown
2000-07-07 BR BRPI0012421-4A patent/BR0012421B1/en not_active IP Right Cessation
2000-07-07 JP JP2001509314A patent/JP4430278B2/en not_active Expired - Fee Related
2000-07-07 CN CNB008101906A patent/CN1254315C/en not_active IP Right Cessation
2000-07-07 DK DK00948463T patent/DK1198299T3/en active
2001-12-20 IL IL147215A patent/IL147215A/en not_active IP Right Cessation
2001-12-21 ZA ZA200110531A patent/ZA200110531B/en unknown
2002-01-11 NO NO20020150A patent/NO20020150L/en not_active Application Discontinuation
2002-09-27 HK HK02107167A patent/HK1045474A1/en not_active IP Right Cessation
2008-09-15 CY CY20081100987T patent/CY1109009T1/en unknown
DE60039516D1 (en) 2008-08-28
JP2003504280A (en) 2003-02-04
WO2001003851A1 (en) 2001-01-18
SE9902672D0 (en) 1999-07-12
SI1198299T1 (en) 2008-12-31
NZ516560A (en) 2003-09-26
TW500613B (en) 2002-09-01
CA2378093A1 (en) 2001-01-18
JP4430278B2 (en) 2010-03-10
CN1360523A (en) 2002-07-24
DK1198299T3 (en) 2008-10-13
ZA200110531B (en) 2003-03-24
US6510847B1 (en) 2003-01-28
CA2378093C (en) 2008-01-29
IL147215D0 (en) 2002-08-14
CY1109009T1 (en) 2014-07-02
EP1198299A1 (en) 2002-04-24
NO20020150L (en) 2002-03-07
MXPA02000347A (en) 2002-07-02
BR0012421A (en) 2002-04-02
NO20020150D0 (en) 2002-01-11
AU6194400A (en) 2001-01-30
PT1198299E (en) 2008-09-15
ES2308986T3 (en) 2008-12-16
KR20020028212A (en) 2002-04-16
AT401135T (en) 2008-08-15
HK1045474A1 (en) 2009-01-23
AU775282B2 (en) 2004-07-29
IL147215A (en) 2007-10-31
CN1254315C (en) 2006-05-03
BR0012421B1 (en) 2009-01-13
KR100689945B1 (en) 2007-03-09
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