Source: https://russianpatents.com/patent/245/2451673.html
Timestamp: 2019-06-16 23:48:12
Document Index: 287635611

Matched Legal Cases: ['§ 15', '§ 38', '§ 38', '§ 38', '§ 38', '§ 42', '§ 38', '§ 38', '§ 55', '§ 55', '§ 58', '§ 58', '§ 58', '§ 58', '§ 58', '§ 58', '§ 58', '§ 58', '§ 58']

where either one of X and Y represents N and the other represents CH, or each of X and Y represents N;
And represents aryl, predstavljajushej a phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl, each of which may substituted With1-6-alkyl;
In represents H, cyano or
represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of
C1-6-alkyl, possibly substituted by hydroxy,
NRaRbwhere Raand Rbindependently represent H, C1-6-alkyl or -(CO)-C1-6-alkyl,
-S-C1-6-alkyl,
-(SO2)-C1-6-alkyl,
-(SO2)-NRcRdwhere Rcand Rdindependently represent H,
C1-6-Alki is, possibly substituted by hydroxy,
-(CO)C1-6-alkyl, possibly substituted C1-6-alkoxy,
-(CH2CH2O)nCHRewhere Rerepresents N or CH2HE, and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10,
-(CH2)m-aryl, where m has a value of 1 or 2 and the aryl possibly substituted, halogen or C1-6-alkoxy,
-(CH2)p-C3-6-cycloalkyl, where p is 0 or 1,
5 - or 6-membered heteroseksualci, with one oxygen atom in the cycle,
-(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5-, or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of
hydroxy, C1-6-alkyl, C1-6-alkoxy, which is substituted by hydroxy, and 5 - or 6-membered, heteroaromatic containing as the heteroatom nitrogen,
NHSO2-C1-6-alkyl and
NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl, -(CO)O-C1-6-alkyl, or Rhand Ritogether with the nitrogen atom to which is neither attached, form morpholinyl;
R1represents H, a halogen atom, a C1-6-alkyl, possibly substituted by hydroxy, C1-6-alkoxy, C1-6-halogenoalkane,3-6-cycloalkyl;
R2represents H, cyano, halogen atom, With1-6-halogenoalkane, C1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl or C3-6-cycloalkyl;
R3represents a halogen atom, H, C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl, C3-6-cycloalkyl, C1-6-halogenoalkane;
R4represents H or halogeno;
and its pharmaceutically acceptable salts, provided that 6-methyl-2,4-diphenylpyridine, 2,4-diphenylpyridine, 2,4-diphenylpyridine, 6-phenyl-2,2'-bipyridine, 6,6'-dimethyl-(4-methoxyphenyl)-2,2'-bipyridine, 6,6'-dimethyl-(4,4'-diphenyl)-2,2'-bipyridine, 6,6'-dimethyl-4,4'-bis[4-were]-2,2'-bipyridine, 2,6-diphenyl-4-triptorelin, 2-(4-chlorophenyl)-6-phenyl-4-triptorelin, 2-(4-methoxyphenyl)-6-phenyl-4-triptorelin, 2-(4-were)-6-phenyl-4-triptorelin, 2,6-diphenylpyridine, 4-methyl-2,6-diphenylpyridine, 2,6-diphenylpyridine, 6-phenyl-2-thiophene-2-yl-pyrimidine, 6-phenyl-2-pyridin-2-yl-pyrimidine, 6-phenyl-2-(2-methylthiazole-4-yl)-pyrimidine, 4-butyl-2,6-diphenylpyridine and 4-cyclohexyl-2,6-diphenylpyridine excluded.
2. The compound according to claim 1 of formula (I), where In is a N or cyan is.
3. The compound according to claim 1 of formula (I), where
NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6-alkyl,
-(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5 - or 6-membered geteroseksualnoe ring, prob is tenderly containing an additional heteroatom, selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of
hydroxy, C1-6-alkyl, C1-6-alkoxy, which is substituted by hydroxy, and 5 - or 6-membered, heteroaromatic containing as the heteroatom nitrogen;
NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl,
-(CO)O-C1-6-alkyl, or Rhand Ritogether with the nitrogen atom to which they are attached, form morpholinyl.
4. The compound according to claim 1, having the following General formula:
And represents aryl represents phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl;
In represents H or possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where estately selected from the group consisting of
-NRaRbwhere Raand Rbindependently represent H, C1-6-alkyl, -(CO)-C1-6-alkyl,
-(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, -(CO)-C1-6-alkyl;
R1represents H, a halogen atom, a C1-6-alkyl, C1-6-alkoxy, C1-6-halogenoalkane,3-6-cycloalkyl;
R2represents H, a halogen atom, a C1-6-halogenoalkane, C1-6-alkyl or C3-6-cycloalkyl;
R3represents a halogen atom, H, C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl, C3-6-cycloalkyl,1-6-halogenoalkane,
5. Compounds according to claim 1 of formula (I)having the following General formula (Ia):
where a, b, R1, R2, R3and R4are as defined in claim 1.
6. Compounds according to claim 5 of formula (Ia), where
And represents aryl represents phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl, each of which may substituted C1-6-alkyl;
In represents the or cyano;
R1represents a C1-6-alkyl or C1-6-halogenoalkane;
R2represents a halogen atom or With1-6-halogenoalkane;
R3represents H, a halogen atom, a C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl and C1-6-halogenoalkane;
7. Compounds according to claim 5 of formula (Ia), where
And represents aryl, predstavljajushej a phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl;
With1-6-alkyl, possibly substituted by hydroxy,
NRaRbwhere Raand Rbindependently represent H or -(CO)1-6-alkyl,
-(CO)1-6the alkyl may someseni the C 1-6-alkoxy,
-(CH2)m-aryl, where m has a value of 1 or 2,
-(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5 - or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of
hydroxyl or C1-6-alkyl,
NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl;
R2represents a halogen atom or C1-6-halogenoalkane;
R3represents H, a halogen atom, a C1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl and C1-6-halogenoalkane;
8. Compounds according to claim 5 of formula (Ia)having the following formula (Ia1):
where, R1, R2, R3and R4are as defined in claim 5.
9. The compound of claim 8 of formula (Ia1), where
In represents H or cyano;
10. The compound of claim 8 of formula (Ia1), where
NRaRbwhere Raand Rbindependently represent H,
R1represents a C1-6-alkyl or the 1-6-halogenoalkane;
11. Compounds according to any one of p or 10 of formula (1A1), where a is an unsubstituted aryl selected from phenyl, or unsubstituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur.
12. Compounds according to claim 11 of formula (Ia1), where these compounds selected from the group consisting of
2-(3-Pyridin-3-yl-phenyl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
4-(4-Chloro-phenyl)-2-(3-pyridin-3-yl-phenyl)-6-trifluoromethyl-pyrimidine and
4-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl.
13. Compounds according to any one of p or 10 of formula (Ia1), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of C1-6-alkyl, possibly substituted by hydroxy.
14. Connection 13 of formula (Ia1), where these compounds selected from the group consisting of
2-[3-(2,6-is imethyl-pyridin-4-yl)-phenyl]-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine and
{3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-4-yl}-methanol.
15. Compounds according to any one of p or 10 of formula (Ia1), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of NRaRbwhere Raand Rbindependently represent N.
16. Connections § 15 of the formula (1A1), where these compounds selected from the group consisting of
5-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-f the Nile}-pyrimidine-2-ylamine;
5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-4-ylamine;
5-{3-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-(3-{4-[3-(2,2,2-Cryptor-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine-2-yl}-phenyl)-pyridine-2-ylamine;
5-(3-{4-[3-(2,2,2-Cryptor-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine-2-yl}-phenyl)-pyrimidine-2-ylamine;
5-{3-[4-Trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2'-yl]-phenyl}-pyridine-2-ylamine;
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-ylamine and
5-{3-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-phenyl}-pyridine-2-ylamine.
17. Compounds according to any one of p or 10 of formula (Ia1), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of -(SO2)-C1-6-alkyl or -(SO2)-NRcRdwhere Rcand Rd independently represent N or C1-6-alkyl, possibly substituted by hydroxyl.
18. Connection 17 of formula (Ia1), where these compounds selected from the group consisting of
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid tert-butylamide;
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid tert-butylamide;
3'-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2'-yl]-biphenyl-3-sulfonic acid amide;
3'-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid tert-butylamide;
5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
5-{3-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
3'-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(3,4-Dichloro-phenyl)-methyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
2-(3'-Methanesulfonyl-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
3'-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
5-{3-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid (2-hydroxy-ethyl)-amide;
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid bis-(2-hydroxy-ethyl)-amide;
3'-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
3'-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(2,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-su is honowai acid amide;
5-{3-[4-(2,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide;
3'-[4-(3-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-biphenyl-3-sulfonic acid amide and
5-{3-[4-(3-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide.
19. Compounds according to any one of p or 10 of formula (Ia1), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are NHSO2-C1-6-alkyl.
20. Compounds according to claim 19 of the formula (Ia1), where the specified connection is {3'-[4 - Trifluoromethyl-6-(4-trift rmeil-phenyl)-pyrimidine-2-yl]-biphenyl-3-yl}-methanesulfonamide.
21. Compounds according to any one of p or 10 of formula (Ia1), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl.
22. Connection item 21 of formula (Ia1), where these compounds selected from the group consisting of N-{3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-yl}-sulphonamide and N-{3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-biphenyl-3-yl}-N',N'-dimethyl-sulphonamide.
23. Compounds according to claim 5 of formula (Ia)having the following formula (Ia2):
where, R1, R2,R3and R4are as defined in claim 5, and 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen or sulfur, can be selected from the group consisting of imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl.
24. Compounds according to item 23 of formula (Ia2), where
R2represents a halogen atom or C1-6-halogenoalkane, R3represents H, a halogen atom, a C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl and C1-6-halogenoalkane;
25. Compounds according to any one of p and 24 of formula (Ia2), where In is an N.
26. Connection A.25 formula (Ia2), where these compounds selected from the group consisting of
4-(4-Chloro-phenyl)-2-imidazol-1-yl-6-trifluoromethyl-pyrimidine;
2-Imidazol-1-yl-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
2-Pyrrol-1-yl-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
4-(4-Chloro-phenyl)-2-pyrrol-1-yl-6-trifluoromethyl-pyrimidine;
2-Pyridin-3-yl-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
4-Deformity-2-pyridin-4-yl-6-(4-trifluoromethyl-phenyl)-pyrimidine and
2-Pyridin-4-yl-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine.
27. Compounds according to item 23 of formula (Ia2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of
-(S 2)-NRcRdwhere Rcand Rdindependently represent H,
-(CO)1-6-alkyl, possibly substituted C1-6-alkoxy,
-(CH2)p-C3-6-cycloalkyl, where p is 0 or 1, and
hydroxy or C1-6-alkyl;
28. Connection item 27 of formula Ia2), where In represents an unsubstituted aryl selected from phenyl, or unsubstituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur.
29. Connection p formula (Ia2), where these compounds selected from the group consisting of
2-(4-Pyridin-3-yl-imidazol-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
4-(4-Chloro-phenyl)-2-(4-pyridin-3-yl-imidazol-1-yl)-6-trifluoromethyl-pyrimidine;
4-(4-Chloro-phenyl)-2-(4-pyridin-4-yl-imidazol-1-yl)-6-trifluoromethyl-pyrimidine;
4-(4-Chloro-phenyl)-2-(3-pyridin-4-yl-[1,2,4]oxadiazol-5-yl)-6-trifluoromethyl-pyrimidine;
4-(4-Chloro-phenyl)-2-(3-pyridin-3-yl-[1,2,4]oxadiazol-5-yl)-6-trifluoromethyl-pyrimidine;
4-(4-Chloro-phenyl)-6-methyl-2-(4-pyridin-3-yl-imidazol-1-yl)-pyrimidine;
4-Methyl-2-(4-pyridin-3-yl-imidazol-1-yl)-6-(4-trifluoromethyl-phenyl)-pyrimidine;
4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']bipyridinyl;
4-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,4']bipyridinyl;
2-(3-Pyridin-4-yl-[1,2,4]triazole-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
2-(3-Pyridin-3-yl-[1,2,4]triazole-1-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine.
30. Connection item 27 of formula (Ia2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle, the selected Isetta, oxygen or sulfur, where the Deputy represents NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6-alkyl.
31. Compounds according to article 30 of the formula (Ia2), where these compounds selected from the group consisting of
4-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
4-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-pyrazole-4-yl}-pyridine-2-ylamine;
5-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyrimidine-2-ylamine;
5-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-pyridine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-pyridine-2-ylamine;
4-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']piperidin the l-6'-ylamine;
5-{1-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{5-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine,
5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-6-cyclopropyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-6-cyclopropyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
4-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{5-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
4-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{1-[4-(3-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridin-ylamine;
N-(5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-yl)-ndimethylacetamide;
5-{5-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-pyridine-2-ylamine;
5-{1-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
4-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{1-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{5-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
4-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
4-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-phenylamine;
4-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
4-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
4-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{1-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidin-ylamine;
5-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{5-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{5-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
4-[4-Methyl-6-(3-methyl-4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-(1-{4-[3-(2,2,2-Cryptor-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine-2-yl}-1H-imidazol-4-yl)-pyridine-2-ylamine;
4-{4-[3-(2,2,2-Cryptor-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine-2-yl}-[2,3']bipyridinyl-6'-ylamine;
5-{5-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{1-[4-Trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
4-[4-Trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{2-Methyl-1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{2-Methyl-1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
4-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-[2,3']bipyridinyl-6'-ylamine;
5-{2-Methyl-1-[4-methyl--(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-[1,2,4]triazole-3-yl}-pyridine-2-ylamine;
5-{1-[4-Isopropyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Isopropyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{5-Methyl-1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(3-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(3-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
5-{1-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine and
5-{1-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine.
32. Connection item 27 of formula (Ia2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a -(SO2)-C1-6-alkyl.
33. Connection p formula (Ia2), where these compounds selected from the group consisting of
4-(4-Chloro-phenyl)-2-[4-(3-methanesulfonyl-phenyl)-imidazol-1-yl]-6-methyl-pyrimidine;
4-(3,4-Dichloro-phenyl)-2-[4-(3-methanesulfonyl-phenyl)-imida the ol-1-yl]-6-methyl-pyrimidine;
2-[4-(3-Methanesulfonyl-phenyl)-imidazol-1-yl]-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine and
2-[2-(3-Methanesulfonyl-phenyl)-pyridin-4-yl]-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine.
34. Connection item 27 of formula (Ia2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a -(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, possibly substituted by hydroxy, -(CO)1-6-alkyl, possibly substituted C1-6-alkoxy, -(CH2CH2O)nCHRewhere Rerepresents N or CH2HE and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -(CH2)m-aryl, where m has a value of 1 or 2, or -(CH2)p-C3-6-cycloalkyl, where p is 0 or 1.
35. The connection 34 of the formula (Ia2), where these compounds selected from the group consisting of
3-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-benzosulfimide;
3-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-benzosulfimide;
4-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-Trifluoromethyl-6-(4-tripto the methyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
5-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-thiophene-2-sulfonic acid amide;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-5-yl}-thiophene-2-sulfonic acid amide;
4-{5-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-(3-Methyl-4-trifluoromethyl-phenyl)6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
3-{5-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
4-{5-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
N-tert-Butyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
3-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
4-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid tert-butylamide;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
5-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
4-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimi the Jn-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{4-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
4-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
2-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
2-{1-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
4-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-(3-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-{1-[4-(3-Chloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{1-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{4-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-Piri is in-2-yl}-thiophene-2-sulfonic acid amide;
5-{4-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
4-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
2-{1-[4-(4-Chloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
2-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
3-{4-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
5-{1-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
4-{1-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide,
4-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-(3-Methyl-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide,
3-{1-[4-(3,4-Dichloro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-tiop is n-2-sulfonic acid amide;
3-{1-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-{1-[4-(4-Chloro-3-methyl-phenyl)-6-methyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
N-tert-Butyl-3-{6-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide,
3-{6-[4-Trifluoromethyl-6-(4-triptoreline)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N,N-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N,N-Bis-(2-hydroxy-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Propionyl 3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid propionyl amide;
N-(2-Hydroxy-ethyl)-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N,N-Bis-(2-hydroxy-ethyl)-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{1-[4-(3,4-is iftar-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{1-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
3-{1-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-{1-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-{4-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(4-Fluoro-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(3,4-Debtor-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide,
N,N-Dimethyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Methyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Isobutyl-N-methyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Methyl-N-propyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Benzyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Phenethyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Cyclopropylmethyl-3-{4-[4-trifluoromethyl-6-(4-three is tormentil-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-Cyclopropyl-3-{4-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(4-Chloro-3-methyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-tert-Butyl-3-{6-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide,
3-{6-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
N-tert-Butyl-3-{6-[4-(4-cyano-phenyl)-6-methyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
3-{6-[4-(4-Cyano-phenyl)-6-methyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
3-(4-{4-[3-(2,2,2-Cryptor-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine-2-yl}-pyridine-2-yl)-benzosulfimide;
3-{4-[4-Trifluoromethyl-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
3-{4-[4-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifloromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide;
5-{4-[4-(3-Ethoxy-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide;
3-{4-[4-Deformity-6-(4-cryptomite is-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzosulfimide and
5-{4-[4-Deformity-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-thiophene-2-sulfonic acid amide.
36. Connection item 27 of formula (Ia2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a -(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5 - or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by hydroxy or C1-6-alkyl.
37. Connection p formula (Ia2), where these compounds selected from the group consisting of
4-(3-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzazolyl)-the research;
2-{2-[3-(4-Methyl-piperazine-1-sulfonyl)-phenyl]-pyridin-4-yl}-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine;
2-{2-[3-(Pyrrolidin-1-sulfonyl)-phenyl]-pyridin-4-yl}-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine and
(RS)-1-(3-{4-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-yl]-pyridine-2-yl}-benzazolyl)-pyrrolidin-3-ol.
38. Compounds according to claim 1 of formula (I) having the following General formula (I-b):
39. Connections § 38 of the formula (IB), where
R2represents H, cyano, halogen atom, With1-6-halogenoalkane,1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl or C3-6-cycloalkyl;
R3represents H, a halogen atom, a C1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl or C1-6-halogenoalkane;
or R2and R3together can form dioxo-bridge,
40. Connections § 38 of the formula (IB), where
And represents aryl represents phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle,selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl, each of which may substituted C1-6-alkyl;
NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6- -S-C1-6-alkyl, -(SO2)-OH, -(SO2)-C1-6-alkyl,
-(CH2)m-aryl, where m has a value of 1 or 2 and the aryl possibly substituted, halogen or1-6-alkoxy,
5 - or 6-membered heteroseksualci, with one oxygen atom in the cycle, -(SO2)-NRfRgwhere Rfand Rgthe place with the nitrogen atom, to which they are attached, form
4-, 5 - or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of
NHSO2-NRhRiwhere Rhand Ri independently represent H, C1-6-alkyl or -(CO)O-C1-6-alkyl;
R2represents H, cyano, halogen atom, With1-6-halogenoalkane, C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl or C3-6-cycloalkyl;
R3represents H, a halogen atom, a C1-6-alkoxy, C1-6-halogenoalkane,1-6-alkyl or C1-6-halogenoalkane;
41. Connections § 38 of the formula (IB)having the following formula (B):
where, R1, R2,R3and R4are such as defined in § 38.
42. Compounds according to paragraph 41 of the formula (B), where a is an unsubstituted aryl selected from phenyl, or unsubstituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur.
43. Connections § 42 of the formula (B), where these compounds selected from the group consisting of
2-Methyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine;
2-Cyclopropyl-6-(3-pyridin-3-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine and
2-Methyl-6-(3-pyridin-4-yl-phenyl)-4-(4-trifluoromethyl-phenyl)-pyridine.
44. Compounds according to paragraph 41 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy represents cyano.
45. Connection item 44 of the formula (B), where the specified connection is a 3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-benzonitrile.
46. Compounds according to paragraph 41, of the formula (161) where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a C1-6-alkyl.
47. The is begins on p.46 of the formula (B), where the specified connection is a 2-Methyl-6-[3-(4-methyl-imidazol-1-yl)-phenyl]-4-(4-trifluoromethyl-phenyl)-pyridine.
48. Compounds according to paragraph 41, of the formula (B) where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy represents NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6-alkyl.
49. Connection p formula (B), where these compounds are
5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-methyl-pyridine-2-yl]-phenyl}-pyrimidine-2-ylamine,
5-{3-[4-(4-Chloro-phenyl)-6-methyl-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl}-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyridin-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyridin-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-{3-[4-(3,4-Dichloro-Fe who yl)-6-methyl-pyridine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[6-Ethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyrimidine-2-ylamine;
5-{3-[6-Ethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-2-ylamine;
5-[3-(4-Benzo[1,3]dioxol-5-yl-6-methyl-pyridine-2-yl)-phenyl]-pyridin-2-ylamine and
4-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-thiazole-2-ylamine.
50. Compounds according to paragraph 41 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a -(SO2)-C1-6-alkyl.
51. Connection item 50 of the formula (B), where the specified connection is a 2-(3'-Methanesulfonyl-biphenyl-3-yl)-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine.
52. Compounds according to paragraph 41 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy -(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, possibly substituted by hydroxy, C1-6-halogenoalkane,1-6-alkoxy, -(CO)1-6-alkyl, possibly substituted C1-6-alkoxy, -(CH2CH2O)nCHRewhere Rerepresents N or CH2The h and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -(CH2)m-aryl, where m has a value of 1 or 2 and the aryl possibly substituted, halogen or1-6-alkoxy, -(CH2)p-C3-6-cycloalkyl, where p is 0 or 1, or 5-or 6-membered heteroseksualci, with one atom of oxygen in the loop.
53. Compounds according to paragraph 52 of the formula (B), where these compounds selected from the group consisting of
3'-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-3-sulfonic acid amide;
5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-3-sulfonic acid amide;
5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide;
3'-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid methoxy-amide;
3'-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide;
3'-[6-Ethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid tert-butylamide;
3'-[6-Ethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide;
4,6-Debtor-3'-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-thiophene-2-sulfo the OIC acid amide;
3'-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide and
N-(tert-Butoxycarbonyl)-N'-(4-{3-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-thiazole-2-yl)-sulphonamide.
54. Compounds according to paragraph 41 of the formula (B)having the following formula (I-b):
where, R1, R2, R3and R4are as defined in paragraph 41.
55. Connections § 38 of the formula (16), having the following formula (B):
where, R1, R2,R3and R4are such as defined in § 38, and 5 - or 6-membered heteroaryl group containing 1-3 heteroatoms in the cycle selected from nitrogen, oxygen or sulfur, can be selected from the group consisting of imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl.
56. Connections § 55 of the formula (I62), where
In represents H or cyano, preferably H;
57 Connection p formula (B), where these connections are selected from the group consisting of
2-Imidazol-1-yl-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine;
4-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-6-methyl-pyridine and
2-Methyl-6-thiazol-2-yl-4-(4-trifluoromethyl-phenyl)-pyridine.
58. Connections § 55 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents selected from the group consisting of
NHSO2-C1-6-alkyl,
NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl or -(CO)O-C1-6-alkyl,
-(SO2)-OH, -(SO2)-NRcRdwhere Rcand Rdindependently represent H,
-(CH2)m-aryl, where m has a value of 1 or 2 and the aryl possibly substituted, halogeno the I 1-6-alkoxy,
5 - or 6-membered heteroseksualci with one oxygen atom in the cycle and is(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5 - or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of
hydroxy, C1-6-alkyl, C1-6-alkoxy, possibly substituted by hydroxy, or heteroaromatic containing as the heteroatom nitrogen;
59. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen the ode or sulfur, where the Deputy is a nitro.
60. Connection p formula (B), where these compounds selected from the group consisting of 6-Methyl-2'-(3-nitro-phenyl)-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl and 4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-2-(3-nitro-phenyl)-pyrimidine.
61. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy represents NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6-alkyl.
62. Connection p formula (B), where these compounds selected from the group consisting of
5-{1-[6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,3',5',3"]terpyridine-6"-ylamine;
5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,3']bipyridinyl-5'-yl]-pyrimidine-2-ylamine;
6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-[2,3',5',3"]terpyridine-6"-ylamine;
6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,2';6',3"]terpyridine-6"-ylamine;
5-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-pyrimidine-2-ylamine;
6-Methyl-4-(4-trifluoromethyl-phenyl-[2,4'; 2',3"]terpyridine-6"-ylamine;
5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-pyrimidine-2-ylamine;
6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-[2,4';2',3"]terpyridine-6"-ylamine;
5-[6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-pyrimidine-2-ylamine;
5-{1-[4-(4-Chloro-phenyl)-6-methyl-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
4-(4-Chloro-phenyl)-6-methyl-[2,3';5',3"]terpyridine-6"-ylamine;
5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiazol-4-yl}-pyridine-2-ylamine;
5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiazol-4-yl}-pyrimidine-2-ylamine,
5-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-[1,2,4]oxadiazol-3-yl}-pyridine-2-ylamine;
5-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-pyridine-2-ylamine;
4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-[2,5']bipyridinyl-2'-ylamine;
5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-4-yl}-pyridine-2-ylamine;
5-{1-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiophene-2-yl}-pyridine-2-ylamine;
5-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiophene-2-yl}-pyrimidine-2-ylamine;
5-{5-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridine-2-yl]-thiophene-2-yl}-pyridine-2-ylamine;
5-{5-[4-(3,4-Dichloro-FeNi is)-6-methyl-pyridine-2-yl]-thiophene-2-yl}-pyrimidine-2-ylamine;
5-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiophene-3-yl}-pyridine-2-ylamine;
3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-phenylamine;
3-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-phenylamine;
3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenylamine;
N-(3-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-phenyl)-ndimethylacetamide;
N-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-ndimethylacetamide;
6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,2';6',4"]terpyridine-2"-ylamine;
4-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-pyridine-2-ylamine and
3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-phenylamine.
63. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a-S-C1-6-alkyl.
64. Connection p formula (B), where the specified connection is a 6-Methyl-6'-(3-methylsulfanyl-phenyl)-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl.
65. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the CEC is e, selected from nitrogen, oxygen or sulfur, where the Deputy represents S(O)2-C1-6-alkyl.
66. Connection p formula (B), where these compounds selected from the group consisting of
2-(3-Methanesulfonyl-phenyl)-4-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine and
6'-(3-Methanesulfonyl-phenyl)-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl.
67. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a -(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, possibly substituted by a hydroxyl or halogen, -(CO)1-6-alkyl, possibly substituted C1-6-alkoxy, -(CH2CH2O)nCHRewhere Rerepresents N or CH2HE, and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -(CH2)m-aryl, possibly substituted, halogen or C1-6-alkoxy, where m has a value of 1 or 2 and the aryl possibly substituted, halogeno, C1-6-alkoxy, or -(CH2)p-C3-6-cycloalkyl, where p is 0 or 1, and 5 - or 6-membered heteroseksualci with one atom of oxygen in the loop.
68. Connection p formula (B), where the decree of the connections selected from the group consisting of
4-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-{5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
N-tert-Butyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-tert-Butyl-3-{4-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-benzosulfimide;
N-tert-Butyl-3-{2-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiazol-4-yl}-benzosulfimide;
3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-benzosulfimide;
3-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiazol-4-yl}-benzosulfimide;
N-tert-Butyl-3-[6-methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
N-tert-Butyl-3-[6-methyl-4-(4-trifluoromethyl-phenyl)-[2,3']bipyridinyl-5'-yl]-benzosulfimide;
3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
N-tert-Butyl-3-{1-[6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,3']bipyridinyl-5'-yl]-benzosulfimide;
3-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
4-Methyl-2-{1-[6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-they are the azole-4-yl}-thiazole-5-sulfonic acid tert-butylamide;
5-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid tert-butylamide;
2-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid tert-butylamide;
5-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-thiophene-2-sulfonic acid tert-butylamide;
5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid tert-butylamide;
5-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-thiophene-2-sulfonic acid tert-butylamide;
4-Methyl-2-{1-[6-trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
2-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
5-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
5-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-thiophene-2-sulfonic acid amide;
5-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid amide;
5-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-thiophene-2-sulfonic acid amide;
5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-thiazol-4-yl}-thiophene-2-sulfonic acid tert-butylamide;
5-{2-[6-Methyl-4-(4-trifluoromethyl-phenyl-pyridine-2-yl]-thiazol-4-yl}-thiophene-2-sulfonic acid amide,
4-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-benzosulfimide;
4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
N-tert-Butyl-3-[4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-benzosulfimide.;
5-[4-(3-Methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid tert-butylamide;
3-[4-(3-Methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
5-[4-(3-Methoxy-4-trifluoromethyl-phenyl)-6-methyl-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid amide;
N-(2-Hydroxy-ethyl)-3-[6-methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-[6-methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-N-propionyl benzosulfimide;
N-(2-Hydroxy-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-(2-Methoxy-ethyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-[2-(2-Hydroxy-ethoxy)-ethyl]-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-[2-(2-Methoxy-ethoxy)-ethyl]-3-[6'-methyl-4'-(4-trift rmeil-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethyl}-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Methyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N,N-Dimethyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Cyclopropyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Cyclopropyl-N-methyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Benzyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-(4-Methoxy-benzyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-(4-Fluoro-benzyl)-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-tert-Butyl-3-[6'-methyl-4'-(4-triptoreline-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-[6'-Methyl-4'-(4-triptoreline-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-tert-Butyl-3-[6'-methyl-4'-(3-methyl-4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-[6'-Hydroxymethyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-[6'-Methyl-4'-(3-methyl-4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Acetyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-[6 who-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-N-(tetrahydro-Piran-4-yl)-benzosulfimide;
3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-N-(2,2,2-Cryptor-ethyl)-benzosulfimide;
N-Ethyl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
N-Butyryl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide and
N-Isobutyryl-3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2')bipyridinyl-6-yl]-benzosulfimide.
69. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a NHSO2-C1-6-alkyl.
70. Connection p formula (B), where these compounds selected from the group consisting of
N-{3-[6-Methyl-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-phenyl}-methanesulfonamide;
N-(3-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-phenyl)-methanesulfonamide and
N-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-methanesulfonamide.
71. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy represents-SO2-OH.
72. Obedinenie on p formula (B), where the specified connection is a 3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide acid.
73. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the Deputy is a NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl or -(CO)O-C1-6-alkyl.
74. Connection p formula (B), where these compounds selected from the group consisting of
N-(tert-Butoxycarbonyl)-N'-{3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-sulphonamide;
N-(tert-Butoxycarbonyl)-N'-(3-{4-[6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-phenyl)-sulphonamide;
N-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-sulphonamide;
N-(3-{4-[6-Methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-phenyl)-sulphonamide and
N,N-(Dimethyl)-N'-{3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-sulphonamide.
75. Connections § 58 of the formula (B), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, color is Yes or sulfur, where the Deputy is a -(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form a 4-, 5 - or 6-membered geteroseksualnoe ring may contain an additional heteroatom selected from nitrogen atom, oxygen atom, sulfur atom, or a group of SO2where the specified 4-, 5 - or 6-membered geteroseksualnoe ring possibly substituted by the Deputy selected from the group consisting of hydroxy, C1-6-alkyl, C1-6-alkoxy, possibly substituted by hydroxy, and heteroaromatic containing as the heteroatom nitrogen.
76. Connection item 75 of the formula (B), where these compounds selected from the group consisting of
6-Methyl-2'-[3-(morpholine-4-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl;
6-Methyl-2'-[3-(thiomorpholine-4-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl;
6-Methyl-2'-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl;
Morpholine-4-sulfonic acid {3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-phenyl}-amide;
6'-[3-(1,1-Dioxo-1-thiomorpholine-4-sulfonyl)-phenyl]-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl;
6-Methyl-6'-[3-(pyrrolidin-1-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl;
6-Methyl-6'-[3-(4-methyl-piperazine-1-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,2']BIP is reinila;
6-Methyl-6'-[3-(morpholine-4-sulfonyl)-phenyl]-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl;
6'-[3-(Azetidin-1-sulfonyl-phenyl]-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl;
1-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzazolyl}-piperidine-4-ol;
1-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzazolyl}-azetidin-3-ol;
6'-[3-(4-Methoxy-piperidine-1-sulfonyl)-phenyl]-6-methyl-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl;
2-(1-{3-[6'-Methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzazolyl}-piperidine-4-yloxy)-ethanol;
6-Methyl-6'-{3-[4-(pyridine-4-yloxy)-piperidine-1-sulfonyl]-phenyl}-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl and
6-Methyl-6'-{3-[4-(pyrimidine-2-yloxy)-piperidine-1-sulfonyl]-phenyl}-4-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl.
77. Compounds according to claim 1 of formula (I)having the following General formula (I-b):
78. Connection p formula (IB), where
And represents aryl, predstavljajushej a phenyl or 5 - or 6-membered heteroaryl containing 1-3 atoms in the cycle, selected from nitrogen, oxygen, or sulfur selected from imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl, each of which may samisens 1-6-alkyl;
R1represents a halogen atom, a C1-6-alkyl, possibly substituted by hydroxy, C1-6-alkoxy, C1-6-halogenoalkane,3-6-cycloalkyl;
R2represents a halogen atom, a C1-6-halogenoalkane,1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl or C3-6-cycloalkyl;
79. Connection p formula (IB), where
C1-6-alkyl, possible substituted hydroxy,
NRaRbwhere Raand RbNezavisimosty a N, C1-6-alkyl or -(CO)-C1-6-alkyl,
C1-6-alkyl, possibly substituted by hydroxy, C1-6-halogenoalkane, C1-6-alkoxy,
5 - or 6-membered heteroseksualci, with one oxygen atom in the cycle, -(SO2)-NRfRgwhere Rfand Rgtogether with the nitrogen atom to which they are attached, form
HSO 2-C1-6-alkyl and
NHSO2-NRhRiwhere Rhand Riindependently represent H, C1-6-alkyl, -(CO)O-C1-6-alkyl, or Rhand Ritogether with the nitrogen atom to which they are attached, form morpholinyl;
R2represents a halogen atom, a C1-6-halogenoalkane, C1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl or C3-6-cycloalkyl;
R3represents a halogen atom, H, C1-6-alkoxy, C1-6-halogenoalkane, C1-6-alkyl, C3-6-cycloalkyl, C1-6-halogenoalkane,
80. Connection p formula (IB)having the following General formula (V):
where, R1, R2,R3and R4are as defined in p.
81. Connection item 80 of the formula (V), where a is an unsubstituted aryl selected from phenyl, or unsubstituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur.
82. Connection p formula (V), where the specified connection is a 2-(3-Pyridin-3-yl-phenyl)-4-trifluoromethyl-6-(4-trifluoromethyl-f the Nile)-pyridine.
83. Connection item 80 of the formula (V), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are NRaRbwhere Raand Rbindependently represent H or -(CO)-C1-6-alkyl.
84. Connection item 80 of the formula (V), where these compounds selected from the group consisting of 5-{3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-2-ylamine and 5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-pyridine-3-sulfonic acid amide.
85. Connection item 80 of the formula (V), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are -(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, possibly substituted by hydroxy, C1-6-halogenoalkane, C1-6-alkoxy, -(CO)C1-6-alkyl, possibly substituted C1-6-alkoxy, -(CH2CH2O)nCHRewhere Rerepresents N or CH2HE, and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -(CH2)m-aryl, where m has a value of 1 or and aryl possibly substituted, halogen or1-6-alkoxy, or -(CH2)p-C3-6-cycloalkyl, where p is 0 or 1, or 5 - or 6-membered heteroseksualci, with one atom of oxygen in the loop.
86. Connection p formula (V), where these compounds selected from the group consisting of
3'-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide;
5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-thiophene-2-sulfonic acid tert-butylamide;
5-{3-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-phenyl}-thiophene-2-sulfonic acid amide and
3'-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-biphenyl-3-sulfonic acid amide.
87. Connection item 80 of the formula (V), having the following General formula (V):
where, R1, R2,R3and R4are as defined in item 80.
88. Connection p formula (IB)having the following General formula (V):
where, R1, R2,R3and R4are as defined in p, and 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen, or sulfur selected from the group consisting of imidazolyl, [1,2,4]oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2,4]triazolyl, thiazolyl and pyrimidinyl.
89. Connection p is ormula (V), where In represents an unsubstituted aryl selected from phenyl, or unsubstituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur.
90. Connection p formula (V), where the specified connection is a 2-(4-Chloro-phenyl)-6-(4-pyridin-3-yl-imidazol-1-yl)-4-trifluoromethyl-pyridine.
91. Connection p, formula (V), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are C1-6-alkyl.
92. Connection p formula (V), where these compounds selected from the group consisting of
4-Methyl-2-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid tert-butylamide and
4-Methyl-2-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide.
93. Connection p formula (1B2), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are NRaRbwhere Raand Rbindependently represent H or -(CO)-C1 -C6-alkyl.
94. Connection p formula (V), where these compounds selected from the group consisting of
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-pyrimidine-2-ylamine;
4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-[2,4',2',3"]terpyridine-6"-ylamine;
5-{1-[6-(4-Chloro-phenyl)-4-trifluoromethyl-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-2-ylamine and
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-[1,2,4]triazole-3-yl}-pyridine-2-ylamine.
95. Connection p formula (V), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl containing 1-3 heteroatom in the cycle selected from nitrogen, oxygen or sulfur, where the substituents are -(SO2)-C1-C6-alkyl.
96. Connection p formula (V), where these compounds selected from the group consisting of
2-{1-[6-Trifluoromethyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide and
2-[4-(3-Methanesulfonyl-phenyl)-imidazol-1-yl]-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine.
97. Connection p formula (V), where represents a possibly substituted aryl selected from phenyl, or substituted 5 - or 6-membered heteroaryl, content is the seer 1-3 heteroatoms in the cycle, selected from nitrogen, oxygen or sulfur, where the substituents are -(SO2)-NRcRdwhere Rcand Rdindependently represent H, C1-6-alkyl, possibly substituted by hydroxy, C1-6-halogenoalkane,1-6-alkoxy, -(CO)1-6-alkyl, possibly substituted C1-6-alkoxy, -(CH2CH2O)nCHRewhere Rerepresents N or CH2HE, and n has a value of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -(CH2)m-aryl, where m has a value of 1 or 2 and the aryl possibly substituted, halogen or1-6-alkoxy, -(CH2)p-C3-6- cycloalkyl, where p is 0 or 1, 5 - or 6-membered heteroseksualci, with one atom of oxygen in the loop.
98. Connection p formula (V), where these compounds selected from the group consisting of
3-{5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-[1,2,4]oxadiazol-3-yl}-benzosulfimide;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid tert-butylamide;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiophene-2-sulfonic acid amide;
N-tert-Butyl-3-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
2-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid tre is-butylamide;
3-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-[1,2,4]triazole-3-yl}-benzosulfimide;
3-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
2-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide,
N-tert-Butyl-3-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
3-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
5-{1-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-pyridine-3-sulfonic acid amide;
N-(2-Hydroxy-1,1-dimethyl-ethyl)-3-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
4-Methyl-2-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid tert-butylamide;
4-Methyl-2-{1-[4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-1H-imidazol-4-yl}-thiazole-5-sulfonic acid amide;
N-tert-Butyl-3-[4-metil-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
N-tert-Butyl-3-{1-[6-(4-chloro-phenyl)-4-methyl-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
N-tert-Butyl-3-[4'-methyl-6'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-{4-[4-Methyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-yl]-pyrimidine-2-yl}-benzosulfimide;
3-[4-ethyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-benzosulfimide;
3-[4'-Methyl-6'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]-benzosulfimide;
3-{1-[6-(4-Chloro-phenyl)-4-methyl-pyridine-2-yl]-1H-imidazol-4-yl}-benzosulfimide;
5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid tert-butylamide;
5-[4-Methyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid tert-butylamide;
5-[4-Methyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid amide and
5-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-[2,4']bipyridinyl-2'-yl]-thiophene-2-sulfonic acid amide.
99. The compound of the formula:
representing 3-[6'-methyl-4'-(4-trifluoromethyl-phenyl)-[2,2']bipyridinyl-6-yl]benzosulfimide.
100. The method of obtaining the compounds of formula (XIII), where a is oxadiazolyl group, including the stage of interaction of the compounds of formula (VIII)
where, R1, R2and R3and X and Y are as defined in claim 1.
101. The method of obtaining the compounds of formula (XIV), where a is oxadiazolyl group, including the stage of interaction of the compounds of formula (IV)
the compound of formula (XII)
102. The method of obtaining the compounds of formula (XV), where a is as defined for formula (I), (I-a), (I-b) or (I-C) in any one of claims 1, 4-6, 7-8, 23, 38-39, 40-41, 54-55, 77-80 and 87-88, but differs from oxadiazole group stage of the interaction between the compounds of formula (X)
with the derived Bronevoy acid of formula-B(OH)2obtaining the compounds of formula (XV)
103. Pharmaceutical composition having the properties of an antagonist of metabotropic glutamate receptors mGluR2 containing compound according to any one of claims 1 to 99 in an effective amount.
104. The use of compounds according to any one of claims 1 to 99 in the manufacture of medicaments for treating or preventing the disease or condition, which plays a role or is involved activation of mGluR2.