Source: http://www.google.com/patents/US6444241?dq=7,328,163
Timestamp: 2017-11-20 16:10:06
Document Index: 500425953

Matched Legal Cases: ['application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09']

Patent US6444241 - Caffeine coated chewing gum product and process of making - Google Patents
A method for producing a chewing gum with a controlled release of caffeine, as well as the chewing gum so produced, is obtained by physically modifying caffeine's properties by coating and drying. Caffeine is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated...http://www.google.com/patents/US6444241?utm_source=gb-gplus-sharePatent US6444241 - Caffeine coated chewing gum product and process of making
Publication number US6444241 B1
Application number US 09/651,514
Publication number 09651514, 651514, US 6444241 B1, US 6444241B1, US-B1-6444241, US6444241 B1, US6444241B1
Inventors Henry T. Tyrpin, Michael P. Russell, David L. Witkewitz, Sonya S. Johnson, Ronald L. Ream, Christine L. Corriveau
Patent Citations (185), Non-Patent Citations (68), Referenced by (47), Classifications (12), Legal Events (8)
US 6444241 B1
1. A method of producing a chewing gum product containing caffeine or a caffeine salt compound comprising the steps of:
a) forming a chewing gum pellet; and
b) applying a coating to the gum pellet by applying a solution containing a sugar or a polyol and caffeine or a caffeine salt compound wherein the coating comprises the caffeine or caffeine salt compound.
2. The method of claim 1 wherein the coating is applied by a panning procedure.
b) applying a film coating to the gum pellet wherein the film coating is formed from a solution of a polymer and a solvent, and includes the caffeine or caffeine salt compound.
7. The method of claim 6 wherein the polymer is selected from the group consisting of shellac, Zein and cellulose-type materials.
a) a chewing gum pellet; and
b) a coating on the pellet, the coating comprising
i) caffeine or a caffeine salt compound and
ii) a sweetener selected from the group consisting of sugars, polyols and mixtures thereof.
9. The product of claim 8 wherein the coating comprises a polyol selected from the group consisting of sorbitol, xylitol, maltitol, lactitol, erythritol, hydrogenated isomaltulose and mixtures thereof.
Chewing Time % Caffeine Release
0 min —
10 min 73
20 min 88
40 min 97
Sugar 61.9 60.4 60.8 60.8 60.8 58.3
Glycerin 1.4 1.4 0.0 0.0 0.0 1.4
Corn Syrup 15.9 15.9 12.9 12.9 12.9 —
Lecithin 0.2 0.2 0.2 0.2 0.2 0.2
Peppermint 0.9 0.9 0.9 0.9 0.9 0.9
Liquid/ 0.5 2.0 6.0 6.0 6.0 20.0
Corn Syrup 12.9 12.9 12.9 12.9 12.9 12.9
Dextrose 9.9 9.9 9.9 9.9 9.9 9.9
Caffeine/ 5.0 5.0 5.0 5.0 5.0 5.0
None HLB = 2 HLB = 4 HLB = 6 HLB = 9 HLB = 12
Synthetic rubber 13
Paraffin Wax 13
Glycerine 1.4
Peppermint Flavor 0.9
Sorbitol 48.8 —
Sugar — 54.7
Mannitol 8.0 —
Gum Base 25.5 20.0
Glycerin 8.5 1.4
Corn Syrup — 12.0
Lycasin brand 6.8 —
Dextrose Monohydrate — 10.0
Peppermint Flavor 1.4 0.9
Active Caffeine 1.0% 1.0%
Sugar Sugarless Sugarless Sugarless
Sugar With Sorbitol With Water With Lycasin No Water
Gum Base 19.2 19.2 25.5 25.5 25.5
Sugar 55.0 53.0 — — —
Sorbitol — 2.0 52.8 48.5 51.3
Mannitol — — 8.0 8.0 12.0
Corn Syrup 13.1 13.1 — — —
Lycasin/Sorbitol — 9.5(a) 6.8(b) —
Glycerin 1.4 1.4 1.5 8.5 8.5
Lecithin — — 0.2 0.2 0.2
Dextrose 9.9 9.9 — — —
Flavor 0.9 0.9 1.5 1.5 1.5
Level of Active 0.5 0.5 1.0 1.0 1.0
(a)liquid sorbitol (70% sorbitol, 30% water)
(b)hydrogenated starch hydrolyzate syrup
Gum Base 19.2 19.2 19.2 19.2 19.2 19.2 19.2
Sugar 58.5 49.5 48.5 48.5 49.5 51.5 51.5
Glycerin 1.4 1.4 1.4 1.4 1.4 1.4 1.4
Corn Syrup 19.0 23.0 19.0 19.0 23.0 16.0 16.0
Dextrose — — 5.0 — — — —
Lactose — — — — 5.0 — —
Fructose — — 5.0 — — — —
Invert Sugar — — — 10.0 — — —
Maltose — — — — — 10.0 —
Palatinose — — — — — — 10.0
Corn Syrup — 5.0 — — — — —
Peppermint 0.9 0.9 0.9 0.9 0.9 0.9 0.9
Level of 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Base 25.5 25.5 25.5 25.5 25.5 25.5 25.5 25.5 25.5
Sorbitol 53.0 46.0 41.0 41.0 41.0 41.0 36.0 37.0 46.0
Sorbitol Liquid/ 17.0 14.0 6.0 — 5.0 — — 6.0(a) 18.0(a)
Mannitol — 10.0 8.0 8.0 8.0 8.0 8.0 8.0 8.0
Maltitol — — — 5.0 — — 5.0 — —
Xylitol — — 15.0 10.0 — — 5.0 15.0 —
Lactitol — — — — 10.0 — — — —
Hydrogenated — — — — — 15.0 10.0 — —
Glycerin 2.0 2.0 2.0 8.0 8.0 8.0 8.0 6.0 —
Flavor 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
Level of Active 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
(a)Lycasin, all others use sorbitol liquid
All of these formulations in Table 6 and Table 7 which use the agglomerated caffeine as described in the examples (38-45) and in the previous encapsulated examples (23-35) would be expected to give a delayed release of caffeine or a fast release of caffeine compared to a product made by adding caffeine directly to gum as a powder.
6 Brochure for "Minerals Technolgies Specialty Minerals", 1998, 19 pages.
7 C. Curtis Vreeland, "Nutraceuticals Fuel Confectionery Growth" Candy R & D, (Mar., 1999), pp. 29, 31-32, 34-35.
8 Chang, Tammy et al., "The Effect of Water-Soluble Vitamin E on Cyclosporine Pharmacokinetics in Healthy Volunteers," Abstract in American Society to Clinical Pharmacology and Therapeutics, 57(2):163, Feb. 1995.
9 Dr. Massimo Calanchi and Dr. Sam Ghanta, "Taste-masking of oral formulations", Eurand International SpA, Pharmaceutical Manufacturing International, 1996 (5 pages).
10 Gumtech article from the Internet "Customized Solutions For Customer Brands", printed Oct. 18, 2000,<http://www.gum-tech.com/cus-brands.html>, 3 pages.
11 Hebert, Mary F. et al.; "Bioavailability of Cyclosporine with Concomitant Rifampin Administration is Markedly Less Than Predicted by Hepatic Enzyme Induction" (1992) Clin. Pharmacol. Ther. 52:453-457.
12 Heritage Consumer Products Co. article from the Internet "Cosmetics and Toiletries, The Heritage Story", printed Jul. 20, 2000,<http://www.cnewsusa.com/Connecticut/14997.html>, 1 page.
13 James G. Elliott, "Application of Antioxidant Vitamins in Foods and Beverages" Food Technology, (Feb., 1999), pp. 46-48.
14 Kitty Broihier, R.D., "Foods of Tomorrow, Milking The Nutrition Market", Food Processing, (Mar., 1999), pp. 41, 42 and 44.
15 Kitty Broihier, R.D., "Tea Time For Nutraceuticals, New Black, Green Tea Products Brew Up a Bevy Of Health Benefits", Food Processing; (Mar., 1999), pp. 59, 61 and 63.
16 Kronbach, Thomas et al.; "Oxidation of Midazolam and Triazolam by Human Liver Cytochrome P450lllA4" (1989) Molec. Pharm. 36:89-96.
17 Lalka et al., "The Hepatic First-Pass Metabolism of Problematic Drugs" (1993) J. Clin. Pharmacol. 33:657-669.
18 Lum et al.; "Clinical Trials of Modulation of Multidrug Resistance. Pharmacokinetic and Pharmacodynamic Considerations" (1993) Cancer 72:3502-3514.
19 Merck Index, 11th Ed., #1635 "Caffeine" (1989), p. 248.
20 Merck Index, 12th Ed., #2337 "Cimetidine" (1996), p. 383.
21 Merck Index, 12th Ed., #3264 "Dimethicone" (1996), p. 544.
22 Merck Index, 12th Ed., #3972 "Famotidine" (1990), p. 667.
23 Merck Index, 12th Ed., #6758 "Nizatidine" (1996), p. 1143.
24 Merck Index, 12th Ed., #6977 "Omeprazole" (1996), p. 1174.
25 Merck Index, 12th Ed., #8272 "Rabeprazole" (1996), p. 1392.
26 Merck Index, 12th Ed., #8286 "Ranitidine" (1996), p. 1395.
27 Muranishi, Shozo; "Absorption Enhancers" (1990) Crit. Rev. Ther. Drug Carrier Sys., 7:1-33.
28 Nielsen et al., P-Glycoprotein as Multidrug Transporter: A Critical Review of Current Multidrug Resistant Cell Lines, Chimica et Biophysica Acta., 1139:169-183 (1992).
29 Product package "Aspergum" distributed by Heritage Consumer Products, LLC (on sale prior to Nov. 27, 1995).
36 Rabeprazole article from the Internet "Raberprazole: Pharmacokinetics and Safety in the Elderly", printed Sep. 22, 2000,<http://www.mmhc.com/cg/articles/CG9905/Hum-phries.html>, 2 pages.
37 Somberg et al.; "The Clinical Implications of First-Pass Metabolism: Treatment Strategies for the 1990's" (1993) J. Clin. Pharmacol. 33:670-673.
39 The Eurand Group, Brochure (undate) (published at least before Nov. 27, 1996), (16 pages).
40 The United States Pharmacopeia The National Formulary-"General Information", dated Jan. 1, 1990 pp 1624-1625 and pp 1696-1697.
41 The United States Pharmacopeia The National Formulary—"General Information", dated Jan. 1, 1990 pp 1624-1625 and pp 1696-1697.
42 U.S. application No. 09/286,818, filed Apr. 6, 1999.
43 U.S. application No. 09/421,905, filed Oct. 20, 1999.
44 U.S. application No. 09/510,878, filed Feb. 23, 2000.
45 U.S. application No. 09/535,458, filed Mar. 24, 2000.
46 U.S. application No. 09/552,290, filed Apr. 19, 2000.
47 U.S. application No. 09/591,256, filed Jun. 9, 2000.
48 U.S. application No. 09/592,400, filed Jun. 13, 2000.
49 U.S. application No. 09/618,808, filed Jul. 18, 2000.
50 U.S. application No. 09/621,643, filed Jul. 21, 2000.
51 U.S. application No. 09/621,780, filed Jul. 21, 2000.
52 U.S. application No. 09/631,326, filed Aug. 3, 2000.
53 U.S. application No. 09/653,669, filed Sep. 1, 2000.
54 U.S. application No. 09/654,464, filed Sep. 1, 2000.
55 U.S. application No. 09/671,552, filed Sep. 27, 2000.
56 U.S. application No. 09/714,571, filed Nov. 16, 2000.
57 U.S. application No. 09/747,300, filed Dec. 22, 2000.
58 U.S. application No. 09/747,323, filed Dec. 22, 2000.
59 U.S. application No. 09/748,699, filed Dec. 22, 2000.
60 U.S. application No. 09/749,983, filed Dec. 27, 2000.
61 U.S. application No. 09/759,561, filed Jan. 11, 2001.
62 U.S. application No. 09/759,838, filed Jan. 11, 2001.
63 Van Hoogdalem et al.; "Intestinal Drug Absorption Enhancement: An Overview" (1989) Pharmacol. Ther. 44:407-443.
64 Warren et al.; "Increased Accumulation of Drugs in Multidrug-Resistant Cell Induced by Liposomes" (1992) Cancer Research 52:3241-3245.
65 Watkins, Paul B.; "The Role of Cytochromes P-450 in Cyclosporine Metabolism" (1990) J. Am. Acad. Dermacol. 23:1301-1309.
66 Wrighton et al.; "In Vitro Methods for Accessing Human Hepatic Drug Metabolism: Their Use in Drug Development" (1993) 25:453-484.
67 Wu et al.; "Use of IV and Oral Drug Levels from Cyclosporence (CsA) with Concomitant Rifampin to Differentiate Gut Absorption and Metabolism" (1993) Pharm. Res. 10:abstract ppdm8185.
68 Zamora et al.; "Physical-Chemical Properties Shared by Compounds that Modulate Multidrug Resistance in Human Loukemic Cells" (1988) Molec. Pharmacol. 33:454-462.
US7874297 Jun 29, 2006 Jan 25, 2011 Streck John J Tobacco substitute products
US20060153889 * Jan 4, 2006 Jul 13, 2006 Friel Francis M Discontinuous surface coating for particles
US20070000506 * Jun 29, 2006 Jan 4, 2007 Streck John J Tobacco-like products with substitute materials and manufacturing methods
US20080181998 * Jan 29, 2007 Jul 31, 2008 Dakota Valley Products, Inc. Process for processing foodstuffs to prolong freshness
US20080220129 * Jan 25, 2007 Sep 11, 2008 Dakota Valley Products, Inc. Enriched foodstuff and process for enriching the foodstuff
US20090142443 * Nov 25, 2008 Jun 4, 2009 Cadbury Adams Usa Llc Multi-region chewing gum with actives
US20100129522 * Nov 24, 2008 May 27, 2010 Jonathan Morse Caffeinated frozen confections
US20110070287 * Nov 24, 2010 Mar 24, 2011 Bruno Provstgaard Nielsen Film-Coated Compressed Chewing Gum
US20110135708 * Dec 7, 2010 Jun 9, 2011 Brent Holland Dietary supplement - liquid filled gum
US20120183671 * Jan 17, 2012 Jul 19, 2012 Kneller Bruce W Palatinose for enhancing dietary supplement and pharmaceutical delivery
US20130224334 * Apr 12, 2013 Aug 29, 2013 Kraft Foods Global Brands Llc Particulate coating processing
EP1838273A2 * Jan 4, 2006 Oct 3, 2007 ELC Management LLC Discontinuous surface coating for particles
EP1838273A4 * Jan 4, 2006 Feb 20, 2013 Elc Man Llc Discontinuous surface coating for particles
WO2004095942A2 * Apr 16, 2004 Nov 11, 2004 Ipc Prozess Center Gmbh & Co. Caffeinated tablet
WO2004095942A3 * Apr 16, 2004 Jan 6, 2005 Klaus Eichler Caffeinated tablet
WO2006003349A1 * Jun 30, 2004 Jan 12, 2006 Cadbury Schweppes Plc Chewing gum comprising flavor emulsion
WO2009070570A1 * Nov 25, 2008 Jun 4, 2009 Cadbury Adams Usa Llc Multi-region chewing gum with actives
WO2009143841A1 May 26, 2008 Dec 3, 2009 Fertin Pharma A/S Film-coated compressed chewing gum
International Classification A23G4/06, A23G4/20, A23G4/00
Cooperative Classification A23G4/20, A23G4/06, A23G4/068
European Classification A23G4/20, A23G4/06P, A23G4/06
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TYRPIN, HENRY T.;RUSSELL, MICHAEL P.;WITKEWITZ, DAVID L.;AND OTHERS;REEL/FRAME:011061/0461;SIGNING DATES FROM 20000803 TO 20000809