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Patent US5599928 - Texaphyrin compounds having improved functionalization - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsTexaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18...http://www.google.com/patents/US5599928?utm_source=gb-gplus-sharePatent US5599928 - Texaphyrin compounds having improved functionalizationAdvanced Patent SearchPublication numberUS5599928 APublication typeGrantApplication numberUS 08/459,333Publication dateFeb 4, 1997Filing dateJun 2, 1995Priority dateFeb 15, 1994Fee statusLapsedAlso published asCA2182960A1, DE69526782D1, DE69526782T2, EP0745085A1, EP0745085B1, US5599923, WO1995021845A1Publication number08459333, 459333, US 5599928 A, US 5599928A, US-A-5599928, US5599928 A, US5599928AInventorsGregory W. Hemmi, Tarak D. Mody, Jonathan L. SesslerOriginal AssigneeBoard Of Regents, The University Of Texas System, Pharmacyclics, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (31), Non-Patent Citations (244), Referenced by (42), Classifications (40), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetTexaphyrin compounds having improved functionalizationUS 5599928 AAbstract Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic π system of the macrocycle which stabilizes the metal complex to demetallation and the imine bonds to hydrolysis. The addition of substituents to the 12 and 21 positions of the macrocycle offer steric protection for the imine bonds against possible in vivo enzyme hydrolysis. Electron-withdrawing groups at positions 15 and/or 18 render the macrocycle more readily reduced, i.e. the redox potential is lower and the macrocycle more readily gains an electron to form a radical. Such texaphyrins having a low redox potential and imine bond stabilization are useful in a variety of applications.
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C07H21/00, A61K47/48, A61K49/08, A61P35/00, A61K31/40, A61K51/00, A61K49/00, A61K51/04, C07D487/22, A61K41/00Cooperative ClassificationA61K51/04, C07H21/00, A61L2/0011, A61K41/0009, A61K2121/00, A61K49/0021, A61K51/0485, A61K49/106, A61K41/0038, C07D487/22, A61K51/1093, A61K41/0076European ClassificationA61K41/00H, A61L2/00P2, C07H21/00, A61K51/10Z, A61K49/10C8, A61K49/00P4F4C, A61K41/00W10, A61K51/04, A61K41/00P, A61K51/04L16, C07D487/22Legal EventsDateCodeEventDescriptionMar 24, 2009FPExpired due to failure to pay maintenance feeEffective date: 20090204Feb 4, 2009LAPSLapse for failure to pay maintenance feesAug 11, 2008REMIMaintenance fee reminder mailedAug 4, 2004FPAYFee paymentYear of fee payment: 8Aug 3, 2000FPAYFee paymentYear of fee payment: 4Jun 2, 1995ASAssignmentOwner name: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SESSLER, JONATHAN L.;REEL/FRAME:007509/0469Effective date: 19950531Owner name: PHARMACYCLIES, INC., CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HEMMI, GREGORY W.;MODY, TARAK D.;REEL/FRAME:007509/0972;SIGNING DATES FROM 19950526 TO 19950530RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google