Source: https://www.scribd.com/document/204206440/Cephalon-v-Actavis-et-al
Timestamp: 2017-04-23 20:57:18
Document Index: 372236425

Matched Legal Cases: ['§ 271', '§ 1331', '§ 2201', '§ 1391', 'Application No. 22249', '§ 355', '§ 355', '§ 355', '§ 271', '§ 271', '§ 285', '§ 271', '§ 271', '§ 271', '§ 271', '§ 271', '§ 285', '§ 271', '§ 271', '§ 271', '§ 271', '§ 271', '§ 283', '§ 271', '§ 285']

Cephalon v. Actavis et. al.
ScribdBrowseInterestsPolitics & Current AffairsCareer & MoneyPersonal GrowthFictionHealth & FitnessLifestyleEntertainmentBiographies & HistoryScience & TechBrowse byBooksAudiobooksNews & MagazinesSheet MusicBrowse allUploadSign inJoinCephalon v. Actavis et. al.Uploaded by PriorSmartPatentPatent InfringementTitle 35 Of The United States CodeFood And Drug AdministrationDelaware0.0 (0)DownloadEmbedDescription: Official Complaint for Patent Infringement in Civil Action No. 1:14-cv-00122-UNA: Cephalon Inc. v. Actavis LLC et. al. Filed in U.S. District Court for the District of Delaware, no judge yet assign...View MoreOfficial Complaint for Patent Infringement in Civil Action No. 1:14-cv-00122-UNA: Cephalon Inc. v. Actavis LLC et. al. Filed in U.S. District Court for the District of Delaware, no judge yet assigned. See http://news.priorsmart.com/-l9Rg for more info.Copyright: Public DomainDownload as PDF, TXT or read online from ScribdFlag for inappropriate contentIN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF DELAWARE CEPHALON, INC., Plaintiff, v.ACTAVIS LLC, f/k/a ACTAVIS INC., and ACTAVIS ELIZABETH LLC, Defendants. ) ) ) ) ) ) ) ) ) ) )
C.A. No.___________
COMPLAINT Cephalon, Inc. (“Cephalon” or “Plaintiff”) brings this action for patent infringement against Defendants Actavis LLC, formerly known as Actavis Inc., and Actavis Elizabeth LLC (“Actavis” or “Defendants”). 1. This is an action by Cephalon against Actavis for infringement of United States
Patent No. 8,445,524 (“’524 patent”) and United States Patent No. 8,436,190 (“’190 patent”). This action arises out of Actavis’s filing of an Abbreviated New Drug Application (“ANDA”) seeking approval by the United States Food and Drug Administration (“FDA”) to sell generic versions of TREANDA®, Cephalon’s innovative treatment for chronic lymphocytic leukemia and non-Hodgkin’s lymphoma, prior to the expiration of the ’524 and ’190 patents. THE PARTIES Cephalon, Inc. 2. Plaintiff Cephalon, Inc. is a corporation operating and existing under the laws of
Delaware, with its principal place of business at 41 Moores Road, Frazer, Pennsylvania 19355. Cephalon is engaged in the business of research, development, manufacture, and sale of innovative pharmaceutical products throughout the world.
Actavis 3. Upon information and belief, Defendant Actavis LLC, formerly known as Actavis
Inc., is a company organized and existing under the laws of Delaware, having its principal place of business at 60 Columbia Road, Building B, Morristown, New Jersey 07960. 4. Upon information and belief, Defendant Actavis Elizabeth LLC is a company
organized and existing under the laws of Delaware, having its principal place of business at 200 Elmora Avenue, Elizabeth, New Jersey 07202. 5. Upon information and belief, Defendant Actavis Elizabeth LLC is a wholly
owned subsidiary of Actavis LLC. JURISDICTION AND VENUE Subject Matter Jurisdiction 6. 7. This action for patent infringement arises under 35 U.S.C. § 271. This Court has jurisdiction over the subject matter of this action pursuant to 28
U.S.C. §§ 1331 and 1338(a), and the Declaratory Judgment Act, 28 U.S.C §§ 2201 and 2202. Personal Jurisdiction Over Actavis 8. Upon information and belief, this Court has personal jurisdiction over Defendants
Actavis LLC and Actavis Elizabeth LLC. 9. This Court has personal jurisdiction over Defendant Actavis LLC because, among
other things, (1) it is incorporated in the state of Delaware; (2) it is registered to do business in Delaware, including its appointment of a registered agent in Delaware (located at The Corporation Trust Company, Corporation Trust Center, 1209 Orange Street, Wilmington, DE 19801) for the receipt of service of process; (3) it sells a substantial volume of prescription drugs in Delaware; and (4) it has engaged in continuous and systematic contacts with Delaware and/or
purposefully availed itself of this forum by, among other things, making, marketing, shipping, using, offering to sell or selling, or causing others to use, offer to sell, or sell, Actavis pharmaceutical products in this Judicial District, and deriving substantial revenue from such activities, either directly or through one or more of its subsidiaries and/or agents, including Actavis Elizabeth LLC. Actavis also has committed, aided, abetted, contributed to and/or participated in the commission of, the tortious action of patent infringement that has led to foreseeable harm and injury to Cephalon, which manufactures TREANDA®, for sale and use throughout the United States, including the State of Delaware. 10. Upon information and belief, this Court has personal jurisdiction over Defendant
Actavis Elizabeth LLC because, among other things, (1) it is incorporated in the state of Delaware; (2) it is registered to do business in Delaware, including its appointment of a registered agent in Delaware (located at The Corporation Trust Company, Corporation Trust Center, 1209 Orange Street, Wilmington, DE 19801) for the receipt of service of process; (3) it sells a substantial volume of prescription drugs in Delaware; (4) it has engaged in continuous and systematic contacts with Delaware and/or purposefully availed itself of this forum by, among other things, marketing, making, shipping, using, offering to sell or selling, or causing others to use, offer to sell, or sell, Actavis pharmaceutical products in this Judicial District, and deriving substantial revenue from such activities. Upon information and belief, Defendant Actavis Elizabeth LLC also has committed, aided, abetted, contributed to and/or participated in the commission of, the tortious action of patent infringement that has led to foreseeable harm and injury to Cephalon, which manufactures TREANDA®, for sale and use throughout the United States, including the State of Delaware. Further, upon information and belief, Defendant Actavis Elizabeth LLC holds a “Pharmacy – Wholesale” license from the State of Delaware.
Upon information and belief, this Court also has personal jurisdiction over
Actavis LLC because Actavis LLC previously has availed itself of this forum for the purpose of litigating its patent infringement disputes. See, e.g., Kissei Pharmaceutical Co. v. Hetero USA Inc., C.A. No. 13-1091 (D. Del.). Additionally, this Court has personal jurisdiction over both Actavis LLC and Actavis Elizabeth LLC because they previously have been sued in this Judicial District, did not challenge this Court’s exertion of personal jurisdiction over them, and availed themselves of this forum by asserting counterclaims for the purpose of litigating a patent infringement dispute. See Novartis Pharmaceuticals et al v. Actavis Inc. and Actavis Elizabeth LLC, C.A. No. 12-366-RGA-CJB (D. Del.); Pfizer Inc. et al. v. Actavis Group HF et al., C.A. No. 10-675-LPS (D. Del.); Somaxon Pharmaceuticals Inc. v. Actavis Elizabeth LLC et al., C.A. No. 11-402-RGA (D. Del.). Venue 12. Venue is proper in this Judicial District under 28 U.S.C. §§ 1391 and 1400(b). BACKGROUND The ’524 Patent 13. The ’524 patent, entitled “Solid Forms of Bendamustine Hydrochloride,” was
duly and lawfully issued on May 21, 2013 to inventors Laurent D. Courvoisier, Robert E. McKean, Hans-Joachim Jӓnsch, and Veronique Courvoisier. 14. Cephalon. 15. ’524 patent. Cephalon is the sole owner by assignment of all rights, title and interest in the The named inventors of the ’524 patent assigned their rights in the ’524 patent to
The ’524 patent is listed in FDA publication “Approved Drug Products with
Therapeutic Equivalence Evaluations,” commonly referred to as “the Orange Book” (“Orange Book”), with respect to TREANDA®. 17. The ’524 patent will expire on March 26, 2029. A true and accurate copy of the
’524 patent is attached hereto as Exhibit A. The ’190 Patent 18. The ’190 patent, entitled “Bendamustine Pharmaceutical Compositions,” was duly
and lawfully issued on May 7, 2013 to inventors Jason Edward Brittain and Joe Craig Franklin. 19. Cephalon. 20. ’190 patent. 21. 22. The ’190 patent is listed in the Orange Book with respect to TREANDA®. The ’190 patent will expire on October 26, 2030. A true and accurate copy of the Cephalon is the sole owner by assignment of all rights, title and interest in the The named inventors of the ’190 patent assigned their rights in the ’190 patent to
’190 patent is attached hereto as Exhibit B. The TREANDA® Drug Product 23. Cephalon researched, developed, applied for and obtained FDA approval to
manufacture, sell, promote and/or market bendamustine hydrochloride products known as TREANDA®. 24. Cephalon has been selling, promoting, distributing and marketing TREANDA® in
the United States since 2008. 25. TREANDA® is indicated to treat chronic lymphocytic leukemia and non-
Cephalon holds New Drug Application No. 22249 and No. 22303 under Section
505(a) of the Federal Food, Drug and Cosmetic Act, 21 U.S.C. § 355(a), for multiple TREANDA® products used for treating chronic lymphocytic leukemia and non-Hodgkin’s lymphoma. The Actavis ANDA 27. Actavis filed with FDA an Abbreviated New Drug Application under 21 U.S.C.
§ 355(j) seeking approval to manufacture, use, offer for sale, sell in and import into the United States bendamustine hydrochloride for injection, 25 mg/vial and 100 mg/vial (“Actavis’s Bendamustine Product”) prior to the expiration of the ’524 and ’190 patents. 28. 204208. 29. Actavis also filed with FDA, pursuant to 21 U.S.C. § 355(j)(2)(B)(iv), a FDA assigned the ANDA for Actavis’s Bendamustine Product the number
certification alleging that the claims of the ’524 and ’190 patents are invalid, unenforceable and/or would not be infringed by the manufacture, use, importation, sale or offer for sale of Actavis’s Bendamustine Product (“Actavis’s Paragraph IV Certification”). 30. By letter dated December 30, 2013, Actavis notified Cephalon that it had filed
ANDA No. 204208 seeking approval to market Actavis’s Bendamustine Product prior to the expiration of the ’524 and’190 patents (“Actavis’s Notice Letter”). 31. On January 17, 2014 pursuant to an Offer of Confidential Access, Cephalon
received portions of the ANDA filed by Actavis, and Cephalon has reviewed those portions of the ANDA. 32. This Action is being commenced before the expiration of forty-five days from the
date of receipt of the Actavis Notice Letter.
COUNT I FOR INFRINGEMENT OF U.S. PATENT NO. 8,445,524 BY ACTAVIS 33. The allegations of the proceeding paragraphs 1–32 are re-alleged and incorporated
herein by reference. 34. The use of Actavis’s Bendamustine Product is covered by one or more claims of
the ’524 patent. 35. The commercial manufacture, use, offer for sale, sale, marketing, distribution
and/or importation of Actavis’s Bendamustine Product would infringe one or more claims of the ’524 patent. 36. Under 35 U.S.C. § 271(e)(2)(A), Actavis’s submission to FDA of the Actavis
ANDA to obtain approval for Actavis’s Bendamustine Product with a Paragraph IV Certification related thereto before the expiration of the ’524 patent constitutes an act of infringement, and if approved, the commercial manufacture, use, offer to sell, sale, or importation of Actavis’s Bendamustine Product containing bendamustine hydrochloride, would infringe one or more claims of the ’524 patent. 37. Actavis was aware of the ’524 patent when engaging in these knowing and
purposeful activities and was aware that filing the Actavis ANDA with Actavis’s Paragraph IV Certification with respect to the ’524 patent constituted an act of infringement of the ’524 patent. 38. Upon information and belief, Actavis’s Bendamustine Product contains the same
active pharmaceutical ingredient, bendamustine hydrochloride, as that used in Cephalon’s TREANDA® products and claimed in the ’524 patent. 39. Upon information and belief, the manufacture of Actavis’s Bendamustine Product
is made using the solid form of bendamustine hydrochloride described in one or more claims of the ’524 patent.
Actavis’s use of the solid form of bendamustine hydrochloride in the manufacture
of Actavis’s Bendamustine Product infringes one or more claims of the ’524 patent. 41. Upon information and belief, Actavis plans and intends to, and will, infringe the
’524 patent immediately and imminently upon approval of the Actavis ANDA. 42. Upon information and belief, Actavis, under 35 U.S.C. § 271(b), acted in concert,
actively supported, participated in, encouraged, and/or induced the infringement of one or more claims of the ’524 patent. 43. Upon information and belief, Actavis plans and intends to, and will, actively
induce infringement of the ’524 patent when the Actavis ANDA is approved, and plans and intends to, and will, do so immediately and imminently upon approval. 44. Upon information and belief, Actavis knows that the solid form of bendamustine
hydrochloride used to manufacture Actavis’s Bendamustine Product is especially made or adapted for use in infringing the ’524 patent and that the solid form of bendamustine hydrochloride used to manufacture Actavis’s Bendamustine Product is not suitable for substantial non-infringing uses. Upon information and belief, Actavis plans and intends to, and will, contribute to the infringement of the ’524 patent immediately and imminently upon approval of the Actavis ANDA. 45. The foregoing actions by Actavis constitute and/or would constitute infringement
of the ’524 patent, active inducement of infringement of the ’524 patent and/or contribution to the infringement by others of the ’524 patent. 46. Upon information and belief, Actavis acted without a reasonable basis for
believing that it would not be liable for infringing the ’524 patent, actively inducing infringement of the ’524 patent and/or contributing to the infringement by others of the ’524 patent.
Cephalon will be substantially and irreparably harmed by Actavis’s infringing
activities unless the Court enjoins those activities. Cephalon will have no adequate remedy at law if Actavis is not enjoined from the commercial manufacture, use, offer to sell, sale in and importation into the United States of Actavis’s Bendamustine Product. 48. Actavis’s activities render this case an exceptional one, and Cephalon is entitled
to an award of their reasonable attorney fees under 35 U.S.C. § 285. COUNT II FOR DECLARATORY JUDGMENT OF INFRINGMENT OF U.S. PATENT NO. 8,445,524 BY ACTAVIS 49. The allegations of the proceeding paragraphs 1–48 are re-alleged and incorporated
herein by reference. 50. Upon information and belief, Actavis plans to begin manufacturing, marketing,
selling, offering to sell and/or importing Actavis’s Bendamustine Product soon after FDA approval of the Actavis ANDA. 51. Such conduct will constitute direct infringement of one or more claims of the ’524
patent under 35 U.S.C. § 271(a), inducement of infringement of the ’524 patent under 35 U.S.C. § 271(b), and contributory infringement under 35 U.S.C. § 271(c). 52. Actavis’s infringing patent activity complained of herein is imminent and will
begin following FDA approval of the Actavis ANDA. 53. As a result of the foregoing facts, there is a real, substantial, and continuing
justiciable controversy between Cephalon and Actavis as to liability for the infringement of the ’524 patent. Actavis’s actions have created in Cephalon a reasonable apprehension of irreparable harm and loss resulting from Actavis’s threatened imminent actions. 54. ’524 patent. Upon information and belief, Actavis will knowingly and willfully infringe the
55. ’524 patent.
Cephalon will be irreparably harmed if Actavis is not enjoined from infringing the
COUNT III FOR INFRINGEMENT OF U.S. PATENT NO. 8,436,190 BY ACTAVIS 56. The allegations of the proceeding paragraphs 1–55 are re-alleged and incorporated
herein by reference. 57. The use of Actavis’s Bendamustine Product is covered by one or more claims of
the ’190 patent. 58. The commercial manufacture, use, offer for sale, sale, marketing, distribution
and/or importation of Actavis’s Bendamustine Product would infringe one or more claims of the ’190 patent. 59. Under 35 U.S.C. § 271(e)(2)(A), Actavis’s submission to FDA of the Actavis
ANDA to obtain approval for Actavis’s Bendamustine Product with a Paragraph IV Certification related thereto before the expiration of the ’190 patent constitutes an act of infringement, and if approved, the commercial manufacture, use, offer to sell, sale, or importation of Actavis’s Bendamustine Product containing bendamustine hydrochloride, would infringe one or more claims of the ’190 patent. 60. Actavis was aware of the ’190 patent when engaging in these knowing and
purposeful activities and was aware that filing the Actavis ANDA with Actavis’s Paragraph IV Certification with respect to the ’190 patent constituted an act of infringement of the ’190 patent. 61. Upon information and belief, Actavis’s Bendamustine Product contains the same
active pharmaceutical ingredient, bendamustine hydrochloride, as that used in Cephalon’s TREANDA® products and claimed in the ’190 patent.
Upon information and belief, the manufacture of Actavis’s Bendamustine Product
is made by lyophilizing the bendamustine hydrochloride pharmaceutical compositions described in one or more claims of the ’190 patent. 63. Actavis’s use of a lyophilized bendamustine hydrochloride pharmaceutical
composition in the manufacture of Actavis’s Bendamustine Product infringes one or more claims of the ’190 patent. 64. Upon information and belief, Actavis plans and intends to, and will, infringe the
’190 patent immediately and imminently upon approval of the Actavis ANDA. 65. Upon information and belief, Actavis, under 35 U.S.C. § 271(b), acted in concert,
actively supported, participated in, encouraged, and/or induced the infringement of one or more claims of the ’190 patent. 66. Upon information and belief, Actavis plans and intends to, and will, actively
induce infringement of the ’190 patent when the Actavis ANDA is approved, and plans and intends to, and will, do so immediately and imminently upon approval. 67. Upon information and belief, Actavis knows that the lyophilized bendamustine
hydrochloride pharmaceutical composition used to manufacture Actavis’s Bendamustine Product is especially made or adapted for use in infringing the ’190 patent and that the bendamustine hydrochloride pharmaceutical composition used to manufacture Actavis’s Bendamustine Product is not suitable for substantial non-infringing uses. Upon information and belief, Actavis plans and intends to, and will, contribute to the infringement of the ’190 patent immediately and imminently upon approval of the Actavis ANDA.
The foregoing actions by Actavis constitute and/or would constitute infringement
of the ’190 patent, active inducement of infringement of the ’190 patent and/or contribution to the infringement by others of the ’190 patent. 69. Upon information and belief, Actavis acted without a reasonable basis for
believing that it would not be liable for infringing the ’190 patent, actively inducing infringement of the ’190 patent and/or contributing to the infringement by others of the ’190 patent. 70. Cephalon will be substantially and irreparably harmed by Actavis’s infringing
activities unless the Court enjoins those activities. Cephalon will have no adequate remedy at law if Actavis is not enjoined from the commercial manufacture, use, offer to sell, sale in and importation into the United States of Actavis’s Bendamustine Product. 71. Actavis’s activities render this case an exceptional one, and Cephalon is entitled
to an award of their reasonable attorney fees under 35 U.S.C. § 285. COUNT IV FOR DECLARATORY JUDGMENT OF INFRINGMENT OF U.S. PATENT NO. 8,436,190 BY ACTAVIS 72. The allegations of the proceeding paragraphs 1–71 are re-alleged and incorporated
herein by reference. 73. Upon information and belief, Actavis plans to begin manufacturing, marketing,
selling, offering to sell and/or importing Actavis’s Bendamustine Product soon after FDA approval of the Actavis ANDA. 74. Such conduct will constitute direct infringement of one or more claims on the
’190 patent under 35 U.S.C. § 271(a), inducement of infringement of the ’190 patent under 35 U.S.C. § 271(b), and contributory infringement under 35 U.S.C. § 271(c). 75. Actavis’s infringing patent activity complained of herein is imminent and will
begin following FDA approval of the Actavis ANDA.
As a result of the foregoing facts, there is a real, substantial, and continuing
justiciable controversy between Cephalon and Actavis as to liability for the infringement of the ’190 patent. Actavis’s actions have created in Cephalon a reasonable apprehension of irreparable harm and loss resulting from Actavis’ threatened imminent actions. 77. ’190 patent. 78. ’190 patent. PRAYER FOR RELIEF WHEREFORE, Cephalon respectfully request the following relief: a. b. a judgment that the ’524 and ’190 patents are valid and enforceable; a judgment that Actavis’s submission of the Actavis ANDA No. 204208, was an Cephalon will be irreparably harmed if Actavis is not enjoined from infringing the Upon information and belief, Actavis will knowingly and willfully infringe the
act of infringement of one or more claims of the ’524 and ’190 patents and that the making, using, offering to sell, selling, marketing, distributing, or importing of Actavis’s Bendamustine Products prior to the expiration of the ’524 and ’190 patents will infringe, actively induce infringement and/or contribute to the infringement of one or more claims of the ’524 and ’190 patents; c. an Order pursuant to 35 U.S.C. § 271(e)(4)(A) providing that the effective date of
any FDA approval of the Actavis ANDA No. 204208 or any product or compound the use of which infringes the ’524 and ’190 patent, shall be a date that is not earlier than the expiration of the ’524 or ’190 patent; d. an Order pursuant to 35 U.S.C. § 271(e)(4)(B) permanently enjoining Actavis and
all persons acting in concert with Actavis from commercially manufacturing, using, offering for
sale, selling, marketing, distributing, or importing Actavis’s Bendamustine Products, or any product or compound the use of which infringes the ’524 and ’190 patents until, or inducing or contributing to the infringement of the ’524 and ’190 patents after the expiration of the ’524 and ’190 patents; e. an Order pursuant to 35 U.S.C. § 283 permanently enjoining Actavis and all
persons acting in concert with Actavis from commercially manufacturing, using, offering for sale, selling, marketing, distributing, or importing Actavis’s Bendamustine Products, or any product or compound the use of which infringes the ’524 and ’190 patents until, or inducing or contributing to the infringement of the ’524 and ’190 patents after the expiration of the ’524 and ’190 patents; f. an Order enjoining Actavis and all persons acting in concert with Actavis from
seeking, obtaining, or maintaining approval of the Actavis ANDA No. 204208 before the expiration of the ’524 and ’190 patents; g. an award of Cephalon’s damages or other monetary relief to compensate
Cephalon if Actavis engages in the commercial manufacture, use, offer to sell, sale or marketing or distribution in, or importation into the United States of Actavis’s Bendamustine Products, or any product or compound the use of which infringes the ’524 and ’190 patents, or the inducement or contribution of the foregoing, prior to the expiration of the ’524 and ’190 patents in accordance with 35 U.S.C. § 271(e)(4)(C); h. a judgment that this is an exceptional case and awarding Cephalon its attorneys’
fees under 35 U.S.C. § 285; i. an award of Cephalon’s reasonable costs and expenses in this action; and
j. and proper.
an award of any further and additional relief to Cephalon as this Court deems just
Respectfully submitted, /s/ Karen E. Keller John W. Shaw (No. 3362) Karen E. Keller (No. 4489) Stephanie E. O’Byrne (No. 4446) SHAW KELLER LLP 300 Delaware Ave., Suite 1120 Wilmington, DE 19801 (302) 298-0700 jshaw@shawkeller.com kkeller@shawkeller.com sobyrne@shawkeller.com Attorneys for Plaintiff Cephalon, Inc.
OF COUNSEL: David M. Hashmall GOODWIN PROCTER LLP The New York Times Building 620 Eighth Avenue New York, NY 10018-1405 (212) 813-8800 Daryl L. Wiesen Emily L. Rapalino Nicholas K. Mitrokostas GOODWIN PROCTER LLP Exchange Place Boston, MA 02109 (617) 570-1000 Dated: January 31, 2014
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