Source: https://patents.google.com/patent/US5152757?oq=flatulence
Timestamp: 2018-03-19 03:26:46
Document Index: 341640904

Matched Legal Cases: ['ART 1', 'ART 2', 'ART 3', 'ART 4', 'ART 5', 'ART 6', 'ART 7', 'ART 8', 'ART 9', 'ART 10', 'ART 11', 'art 1989']

US5152757A - System for diagnosis and treatment of wounds - Google Patents
System for diagnosis and treatment of wounds
US5152757A
US5152757A US07707248 US70724891A US5152757A US 5152757 A US5152757 A US 5152757A US 07707248 US07707248 US 07707248 US 70724891 A US70724891 A US 70724891A US 5152757 A US5152757 A US 5152757A
US07707248
A treatment system according to the invention comprises a chamber, treatment fluid, treatment additives, control over treatment variables and monitoring capabilities. The chamber encloses a predetermined surface area about the wound. The chamber provides protection from the wound from the surrounding non-sterile environment, control of treatment variables, containment for continuous fluid treatment, an effective delivery system, an effective interface between the wound and the environment, direct monitoring of wound physiology and wound diagnosis. The treatment system provides monitoring of the wound which is essential to enhancing the healing process. Monitoring constitutes extraction and analysis of the system fluid and clinical wound diagnosis. The system provides visual monitoring of the wound itself as well as the fluid within the system. The monitoring features of the system, in addition to the precise control over treatment variables, facilitates research.
The present invention overcomes the deficiencies of the prior art and provides a comprehensive treatment system for wounds, burns, skin diseases and the like, to enhance wound healing. A treatment system for wounds and other skin disorders according to the invention comprises a chamber secured about the periphery of a wound, said chamber having portal means for introduction of treatment fluids into the chamber and for extraction of fluid from said chamber, treatment fluid, at least one treatment additive, control means for treatment variables, and monitoring means for monitoring wound conditions. Treatment additives are selected according to wound indications and include growth factors, antibiotics, anesthetics, enzymes and oxygen. Treatment variables are controlled according to wound indications. Examples of treatment variables are temperature, colloid osmotic pressure, ph, ion concentration and oxygen content.
For better understanding of the invention, reference may be made to the accompanying drawings, in which:
The present invention is a system for diagnosis and treatment of wounds. In addition, the treatment system provides protection from the environment to decrease susceptibility to infection and to enhance wound healing. The term "wound" as used herein will refer to a number of conditions including but not limited to burn wounds, incisional wounds, excisional wounds, tumors, skin diseases and other skin disorders. The term "enhanced wound healing" as used herein means accelerated healing, better quality of healing, healing of wounds that would otherwise not heal and the improvement and elimination of other skin conditions. Other skin conditions include conditions normally referred to as cosmetic, such as wrinkles.
CHART 1__________________________________________________________________________PLASTIC SURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Incisional    Normal Saline            Immune Modulators                      q24 h q24 h    Visual    with    Lidocaine                Inspection    Penicillin &            Specific antibiotics    StreptomycinBurn     Normal Saline            Immune Modulators                      2 hrs ×                            2        Protein    with    Lidocaine 24 h           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinTraumatic    Normal Saline            Immune Modulators                      q6 h  6        Protein    with    Lidocaine                Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinInfected Normal Saline            Immune Modulators                      q2 h  12       Protein    with    Lidocaine                Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinDiabetic Normal Saline            Immune Modulators                      q12 h 12       Protein    with    Lidocaine                Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinVascular Normal Saline            Immune Modulators                      q12 h q12 h    Protein    with    Lidocaine                Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinPressure Normal Saline            Immune Modulators                      q12 h 12       ProteinSores    with    Lidocaine                Micro-    Penicillin &            Specific antibiotics     organisms    Streptomycin__________________________________________________________________________
CHART 2__________________________________________________________________________ORTHOPEDIC SURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Open     Normal Saline            Lidocaine q12 h q12 h    ProteinFractures    with    Growth Factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinOpen Joints    Normal Saline            Lidocaine q12 h 12       Protein    with    Growth Factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinExposed  Normal Saline            Lidocaine q12 h 12       ProteinPosthetic    with    Growth Factors           Micro-Material Penicillin &            Specific antibiotics     organisms    StreptomycinOsteo-   Normal Saline            Lidocaine q12 h 12       ProteinMyelitis with    Growth Factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinTraumatic    Normal Saline            Lidocaine q12 h 12       Protein    with    Growth Factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinIncisional    Normal Saline            Lidocaine q12 h q12 h    Visual    with    Immune Modulators        Inspection    Penicillin &            Specific antibiotics    Streptomycin__________________________________________________________________________
CHART 3__________________________________________________________________________DERMATOLOGY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Psoriasis    Normal Saline            Hydrocortisone                      q12 h q12 h    Visual    with    (1 mg/cc)                Inspection    Penicillin &            Non-steroidal anti-    Streptomycin            inflammatory agentsAcne     Normal Saline            Clindomycin                      q12 h 12       Micro-    with                             organisms    Penicillin &    StreptomycinBacterial    Normal Saline            Specific Antibiotics                      q6 h  6        Micro-Infection    with                             organisms    Penicillin &    StreptomycinViral    Normal Saline            Acyclovir q12 h 12       AntibodiesInfection    with                             Micro-    Penicillin &                     organisms    StreptomycinBenign   Normal Saline            Keratolytic agents                      q24 h 24       VisualNeoplasms    with    (such as salicylic       inspection    Penicillin &            acid)    StreptomycinMalignant    Normal Saline            Fluoro-uracil                      q12 h 12       ProteinNeoplasms    with    (3 mgs/ml)               Tumor    Penicillin &                     antigens    Streptomycin                     Visual                                     inspectionMycosis  Normal Saline            Hydrocortisone                      q12 h 12       ProteinFungoides    with    (3 mgs/ml)               Micro-    Penicillin &            Bleomycin                organisms    Streptomycin            (1 mg/cc)__________________________________________________________________________
CHART 4__________________________________________________________________________CARDIO-THORACIC SURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Open Chest    Normal Saline            Lidocaine q12 h q12 h    Protein    with    Growth Factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinOpen     Normal Saline            Lidocaine q12 h 12       ProteinEmpyemas with    Growth factors           Micro-    Penicillin &            Specific antibiotics     organisms    StreptomycinIncisional    Normal Saline            Lidocaine q12 h 12       Visual    with    Immune modulators    Penicillin &    Streptomycin__________________________________________________________________________
CHART 5__________________________________________________________________________OTO-RHINO-LARYNGOLOGY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Chondritis    Normal Saline            Lidocaine q12 h q12 h    Proteinof the Ear    with    Growth Factors           Micro-    Penicillin &            specific antibiotics     organisms    StreptomycinOpen Wounds    Normal Saline            Lidocaine q12 h 12       Protein    with    Growth factors           Micro-    Penicillin &            specific antibiotics     organisms    StreptomycinIncisional    Normal Saline            Lidocaine q12 h 12       Visual    with    Immune modulators    Penicillin &    Streptomycin__________________________________________________________________________
CHART 6__________________________________________________________________________NEUROSURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Open Wound    Normal Saline            Lidocaine q12 h q12 h    Protein    with    Growth Factors           Micro-    Penicillin &            specific antibiotics     organisms    StreptomycinSuperficial    Normal Saline            Lidocaine q6 h  6        ProteinBrain    with    Specific antibiotics     Micro-Abcesses Penicillin &            Growth factors           organisms    StreptomycinInfected Normal Saline            Lidocaine q6 h  6        Protein    with    Specific antibiotics     Micro-    Penicillin &            Growth factors           organisms    StreptomycinOsteo-   Normal Saline            Lidocaine q6 h  6        ProteinMyelitis with    Specific antibiotics     Micro-    Penicillin &            Growth factors           organisms    Streptomycin__________________________________________________________________________
CHART 7__________________________________________________________________________OPHTHALMOLOGY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Bacterial    Normal Saline            Lidocaine q12 h q12 h    ProteinInfection    with    Specific antibiotics     Micro-    Penicillin &            Growth Factors           organisms    StreptomycinViral    Normal Saline            Lidocaine q12 h 12       ProteinInfection    with    Specific antibiotics     Micro-    Penicillin &            Antiviral agents         organisms    Streptomycin            Growth factorsChemical Normal Saline            Lidocaine q1/2 h                            12       ProteinBurns    with    Growth factors           Micro-    Penicillin &            specific antibiotics     organisms    Streptomycin__________________________________________________________________________
CHART 8__________________________________________________________________________VASCULAR SURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Open     Normal Saline            Lidocaine q12 h q12 h    ProteinFractures    with    Specific antibiotics     Micro-    Penicillin &            Growth Factors           organisms    StreptomycinExposed  Normal Saline            Lidocaine q12 h q12 h    ProteinProsthetic    with    Specific antibiotics     Micro-Material Penicillin &            Growth factors           organisms    Streptomycin__________________________________________________________________________
CHART 9__________________________________________________________________________GENERAL SURGERY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Infected Normal Saline            Lidocaine q6 h  q6 h     Bacteria    with    Specific antibiotics     Protein    Penicillin &    StreptomycinAbcesses Normal Saline            Lidocaine q6 h  6        Bacteria    with    Specific antibiotics     Protein    Penicillin &    StreptomycinIncisional    Normal Saline            Lidocaine q6 h  6        Bacteria    with    Specific antibiotics     Protein    Penicillin &    Streptomycin__________________________________________________________________________
CHART 10__________________________________________________________________________GYNECOLOGY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Vaginal  Normal Saline            Lidocaine q6 h  q6 h     ProteinInfection    with    Specific antibiotics     Micro-    Penicillin &            Growth factors           organisms    StreptomycinSuperficial    Normal Saline            Lidocaine q6 h  6        ProteinVulvar   with    Specific antibiotics     Micro-Infection    Penicillin &            Growth factors           organisms    Streptomycin__________________________________________________________________________
CHART 11__________________________________________________________________________MEDICAL ONCOLOGY    TREATMENT            TREATMENT FLUID ADDITIVE MONITOR &WOUND TYPE    FLUID   ADDITIVES CHANGE                            ADJUSTMENT                                     ANALYSIS__________________________________________________________________________Superficial    Normal Saline            Lidocaine q12 h q12 h    ProteinMalignant    with                             Micro-Tunors   Penicillin &                     organisms    StreptomycinAntibiotics    Normal Saline            Specific antibiotics                      q12 h          Proteinto       with                             Micro-Outpatients    Penicillin &                     organisms    Streptomycin__________________________________________________________________________
As noted above, there are a number of treatment variables which may be controlled by the system. One such treatment variable which may be controlled is temperature. It has been found that heating the wound from a temperature of approximately 27° C. (a common temperature of a lower extremity wound) to 37° C. accelerates wound healing. Experimental data has shown that at a wound temperature of approximately 37° C., the rate of wound healing is more than twice as fast as at a temperature of 27° C. The temperature of the wound area can be achieved by heating the treatment fluid. Cooling has also been proven beneficial in the case of acute burn and other traumatic wounds. Cooling reduces pain, swelling and destruction of tissue. In general terms, acute wounds benefit from cooling during the first hours after occurrence of the wound and later, wounds benefit from a temperature of approximately 37° C. Cooling can similarly be effected by cooling the treatment fluid. Generally, a temperature of 20° C. is recommended. In acute traumatic wounds and in burn wounds, a temperature of five degrees centigrade is suggested if the wound area is smaller than ten by ten centimeters. In larger wounds, a cooling temperature of 20° C. is suggested with monitoring of core temperature.
A preferred embodiment of a chamber 10 employed in the above discussed experiments is shown at FIG. 18. The left-hand illustration is a top view and the right-hand illustration is a side view. The chamber 10 is essentially a bandage having a bellows-type construction. The chamber 10 is constructed of clear vinyl although other plastics and like material are contemplated. Of course, it is necessary to ensure that there is no adverse interaction between treatment fluid, treatment additives or treatment variables and the material selected for the chamber. The bellows fold 12 allows for a large capacity for treatment fluid as well as ease of construction. Essentially, an annular base 14 may be heat (or ultrasound) welded to an annular bellows fold 12 piece and a circular top 16 welded to bellows fold 12 piece. Circular top 16 is a substantially transparent material. The remaining components are not necessarily transparent but may be. A transparent annular base may provide easy visual inspection for leakage. An opening 18 in annular base 14 of approximately 2.5×2.5 cm is provided. Of course, the dimensions and basic materials used to fabricate chamber 10 depend on the application and will be apparent to those skilled in the art. The bottom side 15 of annular base 14 is provided with an adhesive tape or coating suitable for securing the chamber to skin. As those skilled in the art will readily recognize, a removable sheet for protecting the adhesive and maintaining the sterility of the interior of the chamber is desirable. The chambers may be stored in a sterile pack for years. This chamber can take many shapes in order to fit wounds from the size of one square centimeter up to the size of a whole extremity. It is important that the adhesive surface be sufficient to secure the bandage to the skin surface to ensure a leak-proof seal.
1. A treatment system for wounds, said treatment system comprising:
a flexible, conformable chamber having a bellows configuration and sealable about the periphery of a wound so that the chamber surface does not contact the wound;
a fluid equivalent to 0.9% saline containing adequate oxygen, low levels of carbon dioxide, and a physiological pH suitable for wound healing within the chamber; and
monitoring means for assessing wound conditions,
wherein the chamber provides control over oxygen concentration, carbon dioxide, and pH.
2. The treatment system according to claim 1 further comprising a treatment additive selected according to wound indications from the group consisting of anesthetics, antibiotics, chemotherapeutics, growth factors, cell culture medium, cells, oxygen, buffering agents, enzymes, and immune modulators.
19. The treatment system according to claim 1 wherein said chamber comprises a:
a first annular ring of flexible sheet material having an inner peripheral edge and an outer peripheral edge and having a top and a bottom;
a second annular ring of flexible sheet material having an inner peripheral edge and an outer peripheral edge, said inner peripheral edge of said second annular ring secured to said inner peripheral edge of said first annular ring; and
a circular piece of flexible sheet material having a peripheral edge secured to said outer edge of said second annular ring;
whereby a collapsible chamber is formed.
20. The treatment system according to claim 19 wherein the bottom of said first annular ring has an adhesive surface.
28. The treatment system according to claim 1 wherein the fluid-filled chamber further comprises a fastener for joining more than one fluid-filled chamber to each other comprising;
a first attachment strip having an adhesive side and an opposing side secured to a first chamber;
a second attachment strip having an adhesive side and an opposing side secured to a second chamber; and
a bridge having one edge secured to the nonadhesive side of said first attachment strip and the other edge secured to the nonadhesive side of said second attachment strip.
29. The treatment system according to claim 27 or 28 wherein said strips and said bridge are a flexible material.
34. A method for treating wounds, said method comprising the steps of:
securing a fluid-filled, flexible, conformable chamber having a bellows configuration and sealable about the periphery of the wound so that the chamber surface does not contact the wound, wherein the chamber provides control over oxygen concentration, carbon dioxide, and pH;
introducing into the chamber a treatment fluid equivalent to 0.9% saline containing adequate oxygen, low levels of carbon dioxide, and a physiological pH suitable for wound healing; and
monitoring wound conditions.
35. The method according to claim 34 further comprising a treatment additive selected according to wound indications from the group consisting of anesthetics, antibiotics, chemotherapeutics, growth factors, cell culture medium, cells, oxygen, buffering agents, enzymes, and immune modulators.
US07707248 1989-12-14 1991-05-22 System for diagnosis and treatment of wounds Expired - Lifetime US5152757A (en)
US08343401 US5661132A (en) 1989-12-14 1994-11-22 Wound healing
US45195789 Continuation 1989-12-14 1989-12-14
US45195789 Continuation-In-Part 1989-12-14 1989-12-14
US07897357 Continuation-In-Part US5423778A (en) 1989-12-14 1992-06-11 System and method for transplantation of cells
US5152757A true US5152757A (en) 1992-10-06
ID=27036583
US07707248 Expired - Lifetime US5152757A (en) 1989-12-14 1991-05-22 System for diagnosis and treatment of wounds
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Owner name: ERIKSSON, ELOF, MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BRIGHAM AND WOMEN S HOSPITAL;REEL/FRAME:007833/0086
Owner name: APPLIED TISSUE TECHNOLOGIES, MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ERIKSSON, ELOF;REEL/FRAME:011575/0319