Source: https://patents.google.com/patent/US9510769B2/en
Timestamp: 2019-06-18 23:20:23
Document Index: 134107956

Matched Legal Cases: ['§120', 'art.\n2', 'art 1', 'Application No. 09727423', 'Application No. 07', 'Application No. 07798369', 'Application No. 09824015', 'Application No. 07', 'Application No. 10', 'art 2002', 'Application No, 2009', 'Application No. 2009', 'Application No. 09824015', 'Application No, 07798369', 'Application No. 08728501']

US9510769B2 - Impedance based anatomy generation - Google Patents
US9510769B2
US9510769B2 US14/259,384 US201414259384A US9510769B2 US 9510769 B2 US9510769 B2 US 9510769B2 US 201414259384 A US201414259384 A US 201414259384A US 9510769 B2 US9510769 B2 US 9510769B2
US14/259,384
US20140235986A1 (en
2014-04-23 Application filed by Rhythmia Medical Inc filed Critical Rhythmia Medical Inc
2014-04-23 Assigned to RHYTHMIA MEDICAL, INC. reassignment RHYTHMIA MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BADICS, ZSOLT, CSENDES, ALPAR, HARLEV, DORON
2014-08-21 Publication of US20140235986A1 publication Critical patent/US20140235986A1/en
2016-12-06 Publication of US9510769B2 publication Critical patent/US9510769B2/en
This application is a continuation application and claims priority under 35 U.S.C. §120 to U.S. application Ser. No. 13/495,541 filed on Jun. 13, 2012, which is a continuation application of U.S. application Ser. No. 12/437,812 filed May 8, 2009. All subject matter set forth in the above referenced application is hereby incorporated by reference into the present application as if fully set forth herein.
A multitude of separate known configurations of CIE need to inject current in order to interrogate the medium. There is a need to determine the source of the injected signal and to trace it to a specific CIE configuration. For example, 3 pairs of CIE can inject the current sequentially, one pair at a time, so that it is possible to trace the source of the measured PME signals to a specific pair. This is called time division multiplexing. In the case of time division multiplexing, CIE are activated in sequence such that at one point in time one pair is activated and at the next point in time another pair is activated. The switching between pairs may occur every cycle (e.g., 1/5 kHz=200 μs) or every few cycles (e.g., 20 cycles, 20×200 μs=4 mS). It should be noted that frequency or code division (spread spectrum) multiplexing, rather than time division may be used to separate the signals emanating from different CIE pairs. In the case of frequency multiplexing all CIE pairs may inject the current at the same time, but each pair uses a different carrier frequency. The signal collected at the PME is filtered according to the frequency, and the signal measured in each frequency is then associated with the appropriate originating pair.
∇·(σ+jωε)∇φ=0 (Eq. 1)
min p _ ⁢  u _ - ϕ _ ⁡ ( p _ )  2 2
Kx=f (Equation 2)
C ⁡ ( x , t , α ) = 1 1 + ⅇ α ⁡ ( x - t )
df×C residual ×C distance >df threshold (Equation 3)
Electro-Anatomical Map (“EAM”) Construction
inserting a catheter into a heart, the catheter comprising multiple, spatially distributed electrodes including multiple sets of electrodes each set comprising at least two electrodes;
for each of the multiple different sets of electrodes, causing current to flow between at least some of the electrodes and in response to current flow, measuring an electrical signal at each of one or more measuring electrodes; and
determining anatomical information about the heart by detecting a boundary of the heart based at least in part on impedance information generated based on the measured signals, wherein:
the anatomical information accounts for a change in conductivity at the cardiac chamber boundary with a first conductivity inside the cardiac chamber boundary and a second conductivity outside the cardiac chamber boundary, the first conductivity being different from the second conductivity; and
the anatomical information comprises a representation of at least a portion of a boundary of the heart.
2. The method of claim 1, wherein the impedance information is based on at least one of a conductivity or permittivity contrast between blood and surrounding tissue.
3. The method of claim 1, wherein the impedance information comprises complex impedance information based on both a permittivity contrast and a conductivity contrast between blood and surrounding tissue.
4. The method of claim 2, wherein detecting the boundary of the heart comprises determining a closed and parameterized surface around at least a portion of the catheter based on the measured signals, the surface representing a surface at which the conductivity value changes.
5. The method of claim 4, wherein the surface provides a boundary between a region represented by the first conductivity inside the surface and a region represented by the second conductivity outside the surface.
6. The method of claim 4, wherein determining the anatomical information further comprises, for each of the determined surfaces selecting one or more regions of the surface corresponding to an expected boundary of the heart based at least in part on a distance between a portion of the surface and the catheter and joining the regions of the determined surfaces corresponding to an expected chamber boundary to generate the anatomical information.
7. The method of claim 6, wherein selecting the one or more regions comprises selecting the one or more regions based at least in part on a magnitude of a distortion field, the distortion field being based at least in part on a difference between a field calculated based on the measurements and a field in a homogonous medium.
8. The method of claim 6, wherein selecting the one or more regions comprises selecting the one or more regions based at least in part on an error calculation in an optimization used to generate the surface.
using the multiple electrodes on the catheter to measure cardiac signals at the catheter electrodes in response to electrical activity in the heart; and
determining physiological information at multiple locations of the boundary of the heart based on positions of the catheter electrodes and the measured cardiac signals.
10. The method of claim 1, further comprising displaying at least a portion of the anatomical information.
a catheter comprising multiple, spatially distributed electrodes including multiple sets of electrodes each set comprising at least two electrodes, the electrodes being configured to inject a current and to measure electrical signals in response to the injected current; and
a processing unit configured to determine anatomical information about the heart by detecting a boundary of the heart based at least in part on impedance information generated based on the measured signals, wherein:
12. The system of claim 11, wherein the processing unit is configured to determine the anatomical information based at least in part on impedance information generated based on the measured signals at the different catheter positions.
13. The system of claim 12, wherein the impedance information is based on a conductivity contrast between blood and surrounding tissue.
14. The system of claim 11, wherein the processing unit is configured to determine the anatomical information by determining closed and parameterized surfaces based on the measured signals, the surfaces each representing a surface at which the conductivity changes.
15. The system of claim 14, wherein the processing unit is configured to, for each of the determined surfaces, select one or more regions of the surface corresponding to a boundary of a portion of the heart based at least in part on a distance between a portion of the surface and the catheter and join the regions of the determined surfaces corresponding to an expected chamber boundary to generate the anatomical information.
16. The system of claim 15, wherein the processing unit is configured to select the one or more regions based at least in part on a magnitude of a distortion field, the distortion field being based at least in part on a difference between a field calculated based on the measurements and a field in a homogonous medium.
17. The system of claim 16, wherein the processing unit is configured to select the one or more regions based at least in part on an error calculation in an optimization used to generate the surface.
18. The system of claim 11, wherein the electrodes on the catheter are further configured to measure cardiac signals in response to electrical activity in the heart and the processing unit is configured to determine physiological information at multiple locations of the boundary of the heart based on the determined positions of the catheter electrodes and the measured cardiac signals.
US14/259,384 2009-05-08 2014-04-23 Impedance based anatomy generation Active 2029-10-07 US9510769B2 (en)
US15/368,661 US20170086705A1 (en) 2009-05-08 2016-12-04 Impedance based anatomy generation
US13/495,541 Continuation US8744566B2 (en) 2009-05-08 2012-06-13 Impedance based anatomy generation
US15/368,661 Continuation US20170086705A1 (en) 2009-05-08 2016-12-04 Impedance based anatomy generation
US20140235986A1 US20140235986A1 (en) 2014-08-21
US9510769B2 true US9510769B2 (en) 2016-12-06
US15/368,661 Pending US20170086705A1 (en) 2009-05-08 2016-12-04 Impedance based anatomy generation
DE102016120804A1 (en) * 2016-11-01 2018-05-03 Olympus Winter & Ibe Gmbh Technical Medical instrument for carrying out an imaging method for examining tissue as well as methods for carrying out an imaging procedure
2016-12-04 US US15/368,661 patent/US20170086705A1/en active Pending
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Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HARLEV, DORON;CSENDES, ALPAR;BADICS, ZSOLT;SIGNING DATES FROM 20080604 TO 20090604;REEL/FRAME:032736/0159