Source: http://www.google.de/patents/US5587371?hl=de
Timestamp: 2013-12-09 15:37:00
Document Index: 5972291

Matched Legal Cases: ['art 1', 'art 1', 'art 1', 'art 1', 'art 1', 'art 1']

Patent US5587371 - Texaphyrin-oligonucleotide conjugates - Google PatenteSuche Bilder Maps Play YouTube News Gmail Drive Mehr » Erweiterte Patentsuche | Anmelden Erweiterte Patentsuche PatenteTexaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals...http://www.google.de/patents/US5587371?utm_source=gb-gplus-sharePatent US5587371 - Texaphyrin-oligonucleotide conjugates Ver�ffentlichungsnummerUS5587371 APublikationstypErteilung AnmeldenummerUS 08/458,909 Ver�ffentlichungsdatum24. Dez. 1996Eingetragen2. Juni 1995 Priorit�tsdatum21. Jan. 1992Geb�hrenstatusBezahltAuch ver�ffentlicht unterCA2173319A1, CA2173319C, DE69432221D1, DE69432221T2, EP0724457A1, EP0724457B1, US5457183, US5580543, US5583220, US5622946, US5632970, US5801229, US6069140, WO1995010307A1 Ver�ffentlichungsnummer08458909, 458909, US 5587371 A, US 5587371A, US-A-5587371, US5587371 A, US5587371A ErfinderGregory W. Hemmi, Vladimir A. Kr al, Darren Magda, Tarak D. Mody, Jonathan L. SesslerUrspr�nglich Bevollm�chtigterBoard Of Trustees, Univ. Of Tx Sys., Pharmacyclics, Inc.Patentzitate (38), Nichtpatentzitate (244), Referenziert von (94), Klassifizierungen (86), Juristische Ereignisse (5) Externe Links: USPTO, USPTO-Zuordnung, EspacenetTexaphyrin-oligonucleotide conjugatesUS 5587371 A Zusammenfassung Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
Patentzitate Zitiertes PatentEingetragen Ver�ffentlichungsdatum Antragsteller TitelUS4318825 *18. Aug. 19809. M�rz 1982Frame Robert RCatalytic composite, and method of manufactureUS4647447 *23. Jan. 19843. M�rz 1987Schering AktiengesellschaftDiagnostic mediaUS4835263 *18. Dez. 198630. Mai 1989Centre National De La Recherche ScientifiqueNovel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis and their useUS4878891 *25. Juni 19877. Nov. 1989Baylor Research FoundationMethod for eradicating infectious biological contaminants in body tissuesUS4880008 *7. Mai 198614. Nov. 1989The General Hospital CorporationVivo enhancement of NMR relaxivityUS4883790 *23. Apr. 198728. Nov. 1989University Of British ColumbiaWavelength-specific cytotoxic agentsUS4899755 *8. Mai 198513. Febr. 1990The General Hospital CorporationHepatobiliary NMR contrast agentsUS4915683 *10. M�rz 198710. Apr. 1990The Medical College Of Wisconsin, Inc.Antiviral method, agents and apparatusUS4935498 *6. M�rz 198919. Juni 1990Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS4959363 *23. Juni 198925. Sept. 1990Sterling Drug Inc.Quinolonecarboxamide compounds, their preparation and use as antivirals.US4977177 *30. Apr. 198511. Dez. 1990Nippon Petrochemicals Company, Ltd.Tetrapyrrole polyaminomonocarboxylic acid therapeutic agentsUS5021236 *2. M�rz 19874. Juni 1991Schering AktiengesellschaftMethod of enhancing NMR imaging using chelated paramagnetic ions bound to biomoleculesUS5030200 *6. Nov. 19899. Juli 1991Baylor Research FoundationMethod for eradicating infectious biological contaminants in body tissuesUS5041078 *21. Dez. 198920. Aug. 1991Baylor Research Foundation, A Nonprofit Corporation Of The State Of TexasPhotodynamic viral deactivation with sapphyrinsUS5141911 *7. Aug. 199025. Aug. 1992AtochemOxidation catalysts based on supported metalloporphyrinUS5162509 *18. Juni 199010. Nov. 1992Board Of Regents, The University Of Texas SystemProcess for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS5242797 *2. Jan. 19927. Sept. 1993Myron J. BlockNucleic acid assay methodUS5252720 *21. Jan. 199212. Okt. 1993Board Of Regents, The University Of Texas SystemMetal complexes of water soluble texaphyrinsUS5256399 *7. Mai 199226. Okt. 1993Board Of Regents, The University Of Texas SystemAromatic pentadentate expanded porphyrins in magnetic resonance imagingUS5272056 *3. Jan. 199121. Dez. 1993The Research Foundation Of State University Of New YorkModification of DNA and oligonucleotides using metal complexes of polyaza ligandsUS5272142 *7. Mai 199221. Dez. 1993Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumorsUS5292414 *20. Apr. 19928. M�rz 1994Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles for singlet oxygen productionUS5302714 *26. Okt. 199212. Apr. 1994Board Of Regents, The University Of Texas SystemSapphyrins, derivatives and synthesesUS5369101 *16. Dez. 199329. Nov. 1994Board Of Regents, The University Of Texas SystemExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesUS5371199 *14. Aug. 19926. Dez. 1994The Trustees Of The University Of PennsylvaniaSubstituted porphyrins, porphyrin-containing polymers, and synthetic methods thereforUS5432171 *28. Juli 199311. Juli 1995Board Of Regents, The University Of Texas SystemWater soluble texaphyrin metal complexes for viral deactivationUS5439570 *25. Aug. 19938. Aug. 1995Board Of Regents, The University Of Texas SystemWater soluble texaphyrin metal complexes for singlet oxygen productionUS5451576 *25. Aug. 199319. Sept. 1995Board Of Regents, The University Of Texas SystemTumor imaging and treatment by water soluble texaphyrin metal complexesUS5457183 *12. Okt. 199310. Okt. 1995Board Of Regents, The University Of Texas SystemHydroxylated texaphyrinsEP0111418A2 *6. Dez. 198320. Juni 1984Edelson, Richard L., Dr.System for externally treating the bloodEP0196515A1 *13. M�rz 19868. Okt. 1986Baxter Travenol Laboratories, Inc.Photodynamic inactivation of virus in therapeutic protein compositionsEP0233701A2 *16. Jan. 198726. Aug. 1987HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.Porphyrin derivativesWO1990010633A1 *6. M�rz 199020. Sept. 1990Univ TexasExpanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocyclesWO1991019730A1 *3. Juni 199115. Dez. 1991Monsanto CoRna hydrolysis/cleavageWO1992001781A1 *27. Juni 199118. Jan. 1992Univ CaliforniaAntibody-mediated cofactor-driven reactionsWO1993014093A1 *7. Jan. 199322. Juli 1993Univ TexasMetal complexes of water soluble texaphyrinsWO1994009003A1 *18. Okt. 199328. Apr. 1994Hiroyuki FurutaSapphyrin derivatives, conjugates and polymers thereof and expanded porphyrin chromatographic supportsWO1994029316A2 *9. Juni 199422. Dez. 1994Pharmacyclics IncTexaphyrin metal complex mediated ester hydrolysis* Vom Pr�fer zitiertNichtpatentzitateReferenz1"2- Athylamino-2-methyl-propanol-(1)", Beilstein's Handbuch, 4:785, 1950.2"Tentative Rules for Carbohydrate Nomenclature Part 1 (1969)," Handbook of Biochemistry and Molecular Biology, 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio, pp. 100-102.3 *2 A thylamino 2 methyl propanol (1) , Beilstein s Handbuch, 4:785, 1950.4Abid et al., "Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine-2,6-dicarboxaldehyde and α,ω-Primary Diamines", Inorg. Chim. Acta. 95:119-125, 1984.5 *Abid et al., Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine 2,6 dicarboxaldehyde and , Primary Diamines , Inorg. Chim. Acta. 95:119 125, 1984.6Acholla et al., "A Binucleating Accordian Tetrapyrrole Macrocycle", Tetrahedron Lett., 25:3269-3270, 1984.7Acholla et al., "Binucleating Tetrapyrrole Macrocycles", J. Am. Chem. Soc., 107:6902-6908, 1985.8 *Acholla et al., A Binucleating Accordian Tetrapyrrole Macrocycle , Tetrahedron Lett., 25:3269 3270, 1984.9 *Acholla et al., Binucleating Tetrapyrrole Macrocycles , J. Am. Chem. Soc., 107:6902 6908, 1985.10Agrawal and Tang, "Efficient Synthesis of Oligoribonucleotide and Its Phosphorothioate Analogue Using H-Phosphonate Approach," Tetrahedron Letters, 31(52):7541-7544, 1990.11Agrawal et al., "Cellular Uptake and Anti-HIV Activity of Oligonucleotides and Their Analogs," Gene Regulation: Biology of Antisense RNA and DNA, 273-283, 1992.12Akhtar et al., "Pharmaceutical Aspects of the Biological Stability and Membrane Transport Characteristics of Antisense Oligonucleotides," Gene Regulation: Biology of Antisense RNA and DNA, 133-145, 1992.13Ansell, "X-Ray Crystal Structure of the Pentagonal Bipyramidal Nickel(11) Complex [Ni.sup.11 (L)(H.sub.2 O).sub.2 ](BF.sub.4).sub.2 and the Selective Stabilisation of the Nickel(1) Oxidation State by a Quinquedentate Macrocyclic Ligand", J. Chem. Soc., Chem. Commun. pp. 546-547, 1982.14 *Ansell, X Ray Crystal Structure of the Pentagonal Bipyramidal Nickel(11) Complex Ni 11 (L)(H 2 O) 2 (BF 4 ) 2 and the Selective Stabilisation of the Nickel(1) Oxidation State by a Quinquedentate Macrocyclic Ligand , J. Chem. Soc., Chem. Commun. pp. 546 547, 1982.15Aoyama et al., "Multi-Point Interaction of Phosphates with Protonated Pyridylporphyrin. Discrimination of Monoalkyl and Dialkyl Phosphates," Chemistry Letters, 1241-1244 (1991).16 *Aoyama et al., Multi Point Interaction of Phosphates with Protonated Pyridylporphyrin. Discrimination of Monoalkyl and Dialkyl Phosphates, Chemistry Letters, 1241 1244 (1991).17Basile et al., "Metal-Activated Hydrolytic Cleavage of DNA," J. Am. Chem. Soc., 109:7550-7551, 1987.18Bauer et al., "Sapphyrines: Novel Aromatic Pentapyrrolic Macrocycles", J. Am. Chem. Soc., 105:6429-6436, 1983.19 *Bauer et al., Sapphyrines: Novel Aromatic Pentapyrrolic Macrocycles , J. Am. Chem. Soc., 105:6429 6436, 1983.20Bhan and Miller, "Photo-Cross Linking of Psoralen-Derivatized Oligonucleoside Methylphosphonates to Single-Stranded DNA," Bioconjugate Chem., 1:82-88, 1990.21 *Bhan and Miller, Photo Cross Linking of Psoralen Derivatized Oligonucleoside Methylphosphonates to Single Stranded DNA, Bioconjugate Chem., 1:82 88, 1990.22Boutorine et al., "Fullerene-Oligonucleotide Conjugates: Photo-Induced Sequence Specific DNA Cleavage", Agnew. Chem. Int. Ed. Engl., 33(23/24):2462-2465, 1994.23 *Boutorine et al., Fullerene Oligonucleotide Conjugates: Photo Induced Sequence Specific DNA Cleavage , Agnew. Chem. Int. Ed. Engl., 33(23/24):2462 2465, 1994.24Bradley et al., "Antisense Therapeutics," Gene Regulation: Biology of Antisense RNA and DNA, 285-293, 1992.25Breslow et al., "Effects of Metal Ions, Including Mg.sup.2+ and Lanthanides, on the Cleavage of Ribonucleotides and RNA Model Compounds," Proc. Natl. Acad. Sci. USA, 88:4080-4083, 1991.26Broadhurst et al., "18- and 22-π-Electron Macrocycles Containing Furan, Pyrrole, and Thiophen Rings", J. Chem. Soc., Chem. Commun. pp. 1480-1482, 1969.27Broadhurst et al., "New Macrocyclic Aromatic Systems Related to Porphins", J. Chem. Soc., Chem. Commun. pp. 23-24, 1969.28Broadhurst et al., "Preparation of Some Sulphur-containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso-Thiaphlorin", J. Chem. Soc., Chem. Commun. pp. 807-809, 1970.29Broadhurst et al., "The Synthesis of 22 π-Electron Macrocycles. Sapphyrins and Related Compounds", J. Chem. Soc. Perkin Trans., 1:2111-2116, 1972.30 *Broadhurst et al., 18 and 22 Electron Macrocycles Containing Furan, Pyrrole, and Thiophen Rings , J. Chem. Soc., Chem. Commun. pp. 1480 1482, 1969.31 *Broadhurst et al., New Macrocyclic Aromatic Systems Related to Porphins , J. Chem. Soc., Chem. Commun. pp. 23 24, 1969.32 *Broadhurst et al., Preparation of Some Sulphur containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso Thiaphlorin , J. Chem. Soc., Chem. Commun. pp. 807 809, 1970.33 *Broadhurst et al., The Synthesis of 22 Electron Macrocycles. Sapphyrins and Related Compounds , J. Chem. Soc. Perkin Trans., 1:2111 2116, 1972.34Brown and Truscott, "New Light on Cancer Therapy," Chemistry in Britain, 955-958, 1993.35 *Brown and Truscott, New Light on Cancer Therapy, Chemistry in Britain, 955 958, 1993.36Browne and Bruice, "Chemistry of Phosphodiesters, DNA and Models. 2. The Hydrolysis of Bis(8-Hydroxyquinoline) Phosphate in the Absence and Presence of Metal Ions," Journal of the American Chemical Society, 114(13):4951-4958, 1992.37Chin and Banaszczyk, "Highly Efficient Hydrolytic Cleavage of Adenosine Monophoshate Resulting in a Binuclear Co(III) Complex with a Novel Doubly Bidentate μ.sup.4 -Phosphato Bridge," J. Am. Chem. Soc., 111:4103-4105, 1989.38Chin and Banaszczyk, "Rate-Determining Complexation in Catalytic Hydrolysis of Unactivated Esters in Neutral Water," J. Am. Chem. Soc., 111:2724-2726, 1989.39Chin and Zou, "Catalytic Hydrolysis of cAMP," Can. J. Chem., 65:1882-1884, 1987.40Chin et al., "Co(III) Complex Promoted Hydrolysis of Phosphate Diesters: Comparison in Reactivity of Rigid cis-Diaquotetraazacobalt(III) Complexes," J. Am. Chem. Soc., 111:186-190, 1989.41Chung et al., "Synthesis and Characterization of a Reactive Binuclear Co(III) Complex. Cooperative Promotion of Phosphodiester Hydrolysis," Tetrahedron Letters, 31(38):5413-5416, 1990.42Claude et al., "Binding of Nucleosides, Nucleotides and Anionic Planar Substrates by Bis-Intercaland Receptor Molecules," J. Chem. Soc. Chem. Commun., 1991, 17:1182-1185.43 *Claude et al., Binding of Nucleosides, Nucleotides and Anionic Planar Substrates by Bis Intercaland Receptor Molecules, J. Chem. Soc. Chem. Commun., 1991, 17:1182 1185.44Cohen, Jack S., "Chemically Modified Oligodeoxynucleotide Analogs as Regulators of Viral and Cellular Gene Expression," Gene Regulation: Biology of Antisense RNA and DNA, 247-259, 1992.45Cramer et al., "Synthesis and Structure of the Chloride and Nitrate Inclusion Complexes of [16-Pyrimidinium crown-4]," J. Am. Chem. Soc., 1991, 113:7033-7034.46 *Cramer et al., Synthesis and Structure of the Chloride and Nitrate Inclusion Complexes of 16 Pyrimidinium crown 4 , J. Am. Chem. Soc., 1991, 113:7033 7034.47Cuellar et al., "Synthesis and Characterization of Metallo and Metal-Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines", Inorg. Chem. 20:3766-3770, 1981.48 *Cuellar et al., Synthesis and Characterization of Metallo and Metal Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines , Inorg. Chem. 20:3766 3770, 1981.49Day et al., "Large Metal Ion-Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2-iminoisoindoline)", J. Am. Chem. Soc., 97:4519-4527, 1975.50 *Day et al., Large Metal Ion Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2 iminoisoindoline) , J. Am. Chem. Soc., 97:4519 4527, 1975.51De Cola et al., "Hexaaza Macrocyclic Complexes of the Lanthanides", Inorg. Chem., 25:1729-1732, 1986.52 *De Cola et al., Hexaaza Macrocyclic Complexes of the Lanthanides , Inorg. Chem., 25:1729 1732, 1986.53Dervan, Peter B., "Design of Sequence-Specific DNA-Binding Molecules," Science, 232:464-471, 1986.54 *Dervan, Peter B., Design of Sequence Specific DNA Binding Molecules, Science, 232:464 471, 1986.55Dietrich et al., "Proton Coupled Membrane Transport of Anions Mediated by Cryptate Carriers," J. Chem. Soc. Chem. Comm., 1988, 11:691-692.56 *Dietrich et al., Proton Coupled Membrane Transport of Anions Mediated by Cryptate Carriers, J. Chem. Soc. Chem. Comm., 1988, 11:691 692.57Dixon et al., "Molecular Recognition: Bis-Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters," J. Am. Chem. Soc., 1992, 114:365-366.58 *Dixon et al., Molecular Recognition: Bis Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters, J. Am. Chem. Soc., 1992, 114:365 366.59Doan et al., "Sequence-targeted Chemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins," Nucleic Acids Research, 15(21):8643-8659, 1987.60Doan et al., "Targeted Cleavage of Polynucleotides by Complementary Oligonucleotides Covalently Linked to Iron-Prophyrins," Biochemistry, 26:6736-6739, 1986.61 *Doan et al., Sequence targeted Chemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins, Nucleic Acids Research, 15(21):8643 8659, 1987.62 *Doan et al., Targeted Cleavage of Polynucleotides by Complementary Oligonucleotides Covalently Linked to Iron Prophyrins, Biochemistry, 26:6736 6739, 1986.63Dolphin et al., "Porphocyanine: An Expanded Tetrapyrrolic Macrocycle," J. Am. Chem. Soc., 115:9301-9302, 1993.64 *Dolphin et al., Porphocyanine: An Expanded Tetrapyrrolic Macrocycle, J. Am. Chem. Soc., 115:9301 9302, 1993.65Dougherty, "Photosensitizers: Therapy and Detection of Malignant Tumors", Photochem. Photobiol., 45:879-889, (1987).66 *Dougherty, Photosensitizers: Therapy and Detection of Malignant Tumors , Photochem. Photobiol., 45:879 889, (1987).67Dreyer and Dervan, "Sequence-specific Cleavage of Single-Stranded DNA: Oligodeoxynucleotide-EDTA 82:968-972, 1985.68 *Dreyer and Dervan, Sequence specific Cleavage of Single Stranded DNA: Oligodeoxynucleotide EDTA FE(II), Proc. Natl. Acad. Sci. USA, 82:968 972, 1985.69Ehrenberg et al., "Spectroscopy, Photokinetics and Cellular Effect of Far-Red and Near Infrared Absorbing Photosensitizers," Proc. SPIE-Int. Soc. Opt. Eng 1992, 1645 (Proc. Opt. Methods Tumor Treat. Dect.: Mech. Tech. Photodyn. Ther . . . , 259-263, 1992.70Ehrenberg et al., "The Binding and Photosensitization Effects of Tetrabenzoporphyrins and Texaphyrin in Bacterial Cells," Lasers in Medical Science, 8:197-203, 1993.71 *Ehrenberg et al., Spectroscopy, Photokinetics and Cellular Effect of Far Red and Near Infrared Absorbing Photosensitizers, Proc. SPIE Int. Soc. Opt. Eng 1992, 1645 ( Proc. Opt. Methods Tumor Treat. Dect.: Mech. Tech. Photodyn. Ther . . . , 259 263, 1992.72 *Ehrenberg et al., The Binding and Photosensitization Effects of Tetrabenzoporphyrins and Texaphyrin in Bacterial Cells, Lasers in Medical Science, 8:197 203, 1993.73Fedorova et al., "Palladium(II)-Coporoporphyrin I as a Photoactivable Group in Sequence-Specific Modification of Nucleic Acids by Oligonucleotide Derivatives," FEBS Lett., 259(2):335-337, 1990.74 *Fedorova et al., Palladium(II) Coporoporphyrin I as a Photoactivable Group in Sequence Specific Modification of Nucleic Acids by Oligonucleotide Derivatives, FEBS Lett., 259(2):335 337, 1990.75Fiel, Robert J., "Porphyrin-Nucleic Acid Interactions: A Review," Journal of Biomolecular Structure & Dynamics, 6(6):1259-1275, 1989.76 *Fiel, Robert J., Porphyrin Nucleic Acid Interactions: A Review, Journal of Biomolecular Structure & Dynamics, 6(6):1259 1275, 1989.77Furuta et al., "Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base-Pairing Agents," Journal of the American Chemical Society, 1991, 113:4706-4707.78Furuta et al., "Phosphate Anion Binding: Enhanced Transport of Nucleotide Monophosphates Using a Sapphyrin Carrier," J. Am. Chem. Soc., 113:6677-6678, 1991.79 *Furuta et al., Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base Pairing Agents, Journal of the American Chemical Society, 1991, 113:4706 4707.80 *Gal a n et al., A Synthetic Receptor for Dinucleotides, J. Am. Chem. Soc., 1991, 113:9424 9425.81 *Gal a n et al., Selective Complexation of Adenosine Monophosphate Nucleotides By Rigid Bicyclic Guanidinium Abiotic Receptors, Tetrahedron Letters, 32(15):1827 1830, 1991.82Gal an et al., "A Synthetic Receptor for Dinucleotides," J. Am. Chem. Soc., 1991, 113:9424-9425.83Gal an et al., "Selective Complexation of Adenosine Monophosphate Nucleotides By Rigid Bicyclic Guanidinium Abiotic Receptors," Tetrahedron Letters, 32(15):1827-1830, 1991.84Goodchild, John, "Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties," Bioconjugate Chemistry, 1(3):165-187, 1990.85 *Goodchild, John, Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties, Bioconjugate Chemistry, 1(3):165 187, 1990.86Gosmann et al., "Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring-Current Effect", Angew. Chem., Int. Ed Engl., 25:1100-1101, (1986).87 *Gosmann et al., Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring Current Effect , Angew. Chem., Int. Ed Engl., 25:1100 1101, (1986).88Gossauer, "Syntheses of Some Unusual Polypyrrole Macrocycles", Bull. Soc. Chim. Belg., 92:793-795, (1983).89 *Gossauer, Syntheses of Some Unusual Polypyrrole Macrocycles , Bull. Soc. Chim. Belg., 92:793 795, (1983).90Groves and Farrell, "DNA Cleavage by a Metal Chelating Tricationic Porphyrin," J. Am. Chem. Soc., 111:4998-5000, 1989.91 *Groves and Farrell, DNA Cleavage by a Metal Chelating Tricationic Porphyrin, J. Am. Chem. Soc., 111:4998 5000, 1989.92Hanvey et al., "Antisense and Antigene Properties of Peptide Nucleic Acids," Science, 258:1481-1485, 1992.93Harriman et al., "Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen", J. Chem. Soc., Chem. Commun., 314-316, 1989. Submitted as A32 in 1449 for UTSB:458.94 *Harriman et al., Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen , J. Chem. Soc., Chem. Commun., 314 316, 1989. Submitted as A32 in 1449 for UTSB:458.95Hayashi et al., "Site-Selective Hydrolysis of tRNA by Lanthanide Metal Complexes," Inorg. Chem., 32:5899-5900, 1993.96Hendry and Sargeson, "Metal Ion Promoted Phosphate Ester Hydrolysis. Intramolecular Attack of Coordinated Hydroxide Ion," J. Am. Chem. Soc., 111:2521-2527, 1989.97Hisatome et al., "Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine- and Thymine-Porphyrin Derivatives," Chemistry Letters, 1990, 2251-2254.98 *Hisatome et al., Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine and Thymine Porphyrin Derivatives, Chemistry Letters, 1990, 2251 2254.99Hosseini et al., "Multiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysis," J. Am. Chem. Soc., 1990, 112:3896-3904.100Hosseini et al., "Multiple Molecular Recognition and Catalysis. Nucleotide Binding and ATP Hydrolysis by a Receptor Molecule Bearing an Anion Binding Site, an Intercalcator Group, and a Catalytic Site," J. Chem. Soc. Chem. Commun., 1988, 9:596-598.101 *Hosseini et al., Multiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysis, J. Am. Chem. Soc., 1990, 112:3896 3904.102 *Hosseini et al., Multiple Molecular Recognition and Catalysis. Nucleotide Binding and ATP Hydrolysis by a Receptor Molecule Bearing an Anion Binding Site, an Intercalcator Group, and a Catalytic Site, J. Chem. Soc. Chem. Commun., 1988, 9:596 598.103Iverson et al., "Interactions Between Expanded Porphyrins and Nucleic Acids," Pure Applied Chemistry, 66(4):845-850, 1994.104 *Iverson et al., Interactions Between Expanded Porphyrins and Nucleic Acids, Pure Applied Chemistry, 66(4):845 850, 1994.105Kim and Chin, "Dimethyl Phosphate Hydrolysis at Neutral pH," J. Am. Chem. Soc., 114:9792-9795, 1992.106Kimura et al., "A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Receptors," J. Org. Chem., 1990, 55(1):46-48.107Kimura et al., "Macrocyclic Polyamines as Biological Cation and Anion Complexones: An Application to Calculi Dissolution," Topics in Current Chemistry, 128, Biomimetic and Bioorganic Chemistry, VII+265P, Springer-Verlag, Berlin, West Germany, pp. 113, 142, 1985.108 *Kimura et al., A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Receptors, J. Org. Chem., 1990, 55(1):46 48.109Knubel et al., "Biomimetic Synthesis of an Octavinylogous Porphyrin with an Aromatic [34] Annulene System", Angew. Chem., Int. Ed. Engl., 27:1170-1172, 1988.110 *Knubel et al., Biomimetic Synthesis of an Octavinylogous Porphyrin with an Aromatic 34 Annulene System , Angew. Chem., Int. Ed. Engl., 27:1170 1172, 1988.111Kobayashi et al., "Uptake of Chlorophyll-Derivatives by Cellular Nuclei and Mitochondria," Photomed. Photobiol., 15:75-84, 1993.112 *Kobayashi et al., Uptake of Chlorophyll Derivatives by Cellular Nuclei and Mitochondria, Photomed. Photobiol., 15:75 84, 1993.113Koenig et al., "PDT of Tumor-Bearing Mice Using Liposome Delivered Texaphyrins," International Conference, Milan, Italy, Biosis citation only, Jun. 24-27, 1992.114 *Koenig et al., PDT of Tumor Bearing Mice Using Liposome Delivered Texaphyrins, International Conference, Milan, Italy, Biosis citation only, Jun. 24 27, 1992.115Kolasa et al., "Trivalent Lanthanide Ions Do Not Cleave RNA in DNA-RNA Hybrids", Inorg. Chem., 32:3983-3984, 1993.116Komiyama et al., "Unprecedentedly Fast Hydrolysis of the RNA Dinucleoside Monophosphates ApA and UpU by Rare Earth Metal Ions," J. Chem. Soc. Chem. Commun., 640-641, 1992.117Lauffer, "Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design", Chem. Rev., 87:901-927, 1987.118 *Lauffer, Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design , Chem. Rev., 87:901 927, 1987.119Le Doan et al., "Sequence-Specific Recognition, Photocrosslinking and Cleavage of the DNA Double Helix by an Oligo-[α]-Thymidylate Covalently Attached to an Azidoproflavine," Nucleic Acids Res., 15:7749-7760, 1987.120Le Doan et al., "Sequence-Targeted Photochemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins," Bioconjugate Chem., 1:108-113, 1990.121 *Le Doan et al., Sequence Specific Recognition, Photocrosslinking and Cleavage of the DNA Double Helix by an Oligo Thymidylate Covalently Attached to an Azidoproflavine, Nucleic Acids Res., 15:7749 7760, 1987.122 *Le Doan et al., Sequence Targeted Photochemical Modifications of Nucleic Acids by Complementary Oligonucleotides Covalently Linked to Porphyrins, Bioconjugate Chem., 1:108 113, 1990.123Lee et al., "Interaction of Psoralen-Derivatized Oligodeoxyribonucleoside Methylphosphonates with Single-Stranded DNA," Biochemistry, 27:3197-3203, 1988.124 *Lee et al., Interaction of Psoralen Derivatized Oligodeoxyribonucleoside Methylphosphonates with Single Stranded DNA, Biochemistry, 27:3197 3203, 1988.125Leff, "Texas `Son-of-Porphyrin` Molecule Lassos Europium to Kill Drug Resistance Gene," BioWorld Today, 5(156):1, 1994.126 *Leff, Texas Son of Porphyrin Molecule Lassos Europium to Kill Drug Resistance Gene, BioWorld Today, 5(156):1, 1994.127LeGoff et al., "Synthesis of a [1,5,1,5] Platyrin, a 26 π-Electron Tetrapyrrolic Annulene", J. Org. Chem., 52:710-711, 1987.128 *LeGoff et al., Synthesis of a 1,5,1,5 Platyrin, a 26 Electron Tetrapyrrolic Annulene , J. Org. Chem., 52:710 711, 1987.129Levina et al., "Photomodification of RNA and DNA Fragments by Oligonucleotide Reagents Bearing Arylazide Groups," Biochimie, 75:25-27, 1993.130 *Levina et al., Photomodification of RNA and DNA Fragments by Oligonucleotide Reagents Bearing Arylazide Groups, Biochimie, 75:25 27, 1993.131Li and Diederich, "Carriers for Liquid Membrane Transport of Nucleotide 5'-Triphosphates," J. Org. Chem., 1992, 47:3449-3454.132 *Li and Diederich, Carriers for Liquid Membrane Transport of Nucleotide 5 Triphosphates, J. Org. Chem., 1992, 47:3449 3454.133Lin et al., "Use of EDTA Derivatization to Characterize Interactions between Oligodeoxyribonucleoside Methylphosphonates and Nucleic Acids," Biochemistry, 28:1054-1061, 1989.134 *Lin et al., Use of EDTA Derivatization to Characterize Interactions between Oligodeoxyribonucleoside Methylphosphonates and Nucleic Acids, Biochemistry, 28:1054 1061, 1989.135Magda et al., "Sequence-Specific Photocleavage of DNA by an Expanded Porphyrin with Irradiation Above 700 nm," J. Am. Chem. Soc., 117:3629-3630, 1995.136Magda et al., "Site-Specific Hydrolysis of RNA by Europium (III) Texaphyrin Conjugated to a Synthetic Oligodeoxyribonucleotide," Journal of the American Chemical Society, 116(16):7439-7440, 1994.137 *Magda et al., Site Specific Hydrolysis of RNA by Europium (III) Texaphyrin Conjugated to a Synthetic Oligodeoxyribonucleotide, Journal of the American Chemical Society, 116(16):7439 7440, 1994.138Maiya et al., "Ground- and Excited-State Spectral and Redox Properties of Cadmium(II) Texaphyrin," Journal of Physical Chemistry, 93(24):8111-8115, 1989.139 *Maiya et al., Ground and Excited State Spectral and Redox Properties of Cadmium(II) Texaphyrin, Journal of Physical Chemistry, 93(24):8111 8115, 1989.140Marks and Stojakowvic, "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato)uranium(VI) and Its Derivatives," J. Am. Chem. Soc., 1978, 1695-1705.141 *Marks and Stojakowvic, Large Metal Ion Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1 iminoisoindolinato)uranium(VI) and Its Derivatives, J. Am. Chem. Soc., 1978, 1695 1705.142Marks et al., "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato) uranium (VI) and Its Derivatives", J. Am. Chem. Soc., 100:1695-1705, 1978.143 *Marks et al., Large Metal Ion Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1 iminoisoindolinato) uranium (VI) and Its Derivatives , J. Am. Chem. Soc., 100:1695 1705, 1978.144Mastruzzo et al., "Targeted Photochemical Modification of HIV-Derived Oligoribonucleotides by Antisense Oligodeoxynucleotides Linked to Porphyrins," Photochem. Photobiol., 60(4):316-322, 1994.145 *Mastruzzo et al., Targeted Photochemical Modification of HIV Derived Oligoribonucleotides by Antisense Oligodeoxynucleotides Linked to Porphyrins, Photochem. Photobiol., 60(4):316 322, 1994.146Matthews et al., "Inactivation of Viruses with Photoactive Compounds," Blood Cells, 18(1):75-89, 1992.147 *Matthews et al., Inactivation of Viruses with Photoactive Compounds, Blood Cells, 18(1):75 89, 1992.148Menger et al., "Phosphate Ester Hydrolysis Catalyzed by Metallomicelles," J. Am. Chem. Soc., 109:2800-2803, 1987.149Modak et al., "Toward Chemical Ribonucleases. 2. Synthesis and Characterization of Nucleoside-Bipyridine Conjugates. Hyodrolytic Cleavage of RNA by Their Copper(II) Complexes," J. Am. Chem. Soc., 113:283-291, 1991.150Morgan and Skalkos, "Second Generation Sensitizers: Where are We and Where Should We Be Going?" Proc. SPIE Int. Soc. Opt. Eng. Ser., 6:87-106, 1990.151Morrow et al., "Efficient Catalytic Cleavage of RNA by Lanthanide(III) Macrocyclic Complexes: Toward Synthetic Nucleases for in Vivo Applications," J. Am. Chem. Soc., 114:1903-1905, 1992.152 *Nam Chiang Wang et al., Pyrrole chemistry. XVII. Alkylation of the pyrrolyl ambident anion, Can. J. Chem., 55:4112 4116, 1977.153Nam-Chiang Wang et al., "Pyrrole chemistry. XVII. Alkylation of the pyrrolyl ambident anion," Can. J. Chem., 55:4112-4116, 1977.154Perrouault et al., "Sequence-Specific Artificial Photo-Induced Endonucleases Based on Triple Helix-Forming Oligonucleotides," Nature, 344:358-360, 1990.155Phillips and Wasserman, "Promise of Radiosensitizers and Radioprotectors in the Treatment of Human Cancer," Cancer Treatment Reports, 68(1):291-301, 1984.156Pieles and Englisch, "Psoralen Covalently Linked to Oligodeoxyribonucleotides: Synthesis, Sequence Specific Recognition of DNA and Photo-Cross-Linking to Pyrimidine Residues of DNA," Nucleic Acids Res., 17(1):285-299, 1989.157Praseuth et al., "Sequence-Specific Binding and Photocrosslinking of α and β Oligodeoxynucleotides to the Major Groove of DNA via Triple-Helix Formation," Proc. Natl. Acad. Sci. USA, 85:1349-1353, 1988.158Praseuth et al., "Sequence-Targeted Photosensitized Reactions in Nucleic Acids by Oligo-α-Deoxynucleotides and Oligo-β-Deoxynucleotides Covalently Linked to Proflavin," Biochemistry, 27:3031-3038, 1988.159Ranganathan et al., "Design of a Chemical Nuclease Model with (Lys).sub.2 Cu as the Core Motif," Journal of the Chemical Society, 4:337-339, 1993.160Rexhausen et al., "The Synthesis of a New 22 π-Electron Macrocycle: Pentaphyrin", J. Chem. Soc., Chem. Commun., p. 275, 1983.161 *Rexhausen et al., The Synthesis of a New 22 Electron Macrocycle: Pentaphyrin , J. Chem. Soc., Chem. Commun., p. 275, 1983.162Schmidtchen, "A Non-Macrocyclic Host for Binding Organic Phosphates in Protic Solvents," Tetrahedron Letters, 1989, 30(34):4493-4496.163 *Schmidtchen, A Non Macrocyclic Host for Binding Organic Phosphates in Protic Solvents, Tetrahedron Letters, 1989, 30(34):4493 4496.164Schneider et al., "Catalysis of the Hydrolysis of Phosphoric Acid Diesters by Lanthanide Ions and the Influence of Ligands," Angew. Chem. Int. Ed. Engl., 32(12):1716-1719, 1993.165Seel and Vogtle, "Molecular Recognition and Transport of Nucleobases-Superiority of Macrobicyclid Host Molecules," Angew, Chem. Int. Ed. Engl., 1991, 30(4):442-444.166 *Seel and Vogtle, Molecular Recognition and Transport of Nucleobases Superiority of Macrobicyclid Host Molecules, Angew, Chem. Int. Ed. Engl., 1991, 30(4):442 444.167Sessler and Burrell, "Expanded Porphyrins, Topics in Current Chemistry", 161:180-273, 1991.168 *Sessler and Burrell, Expanded Porphyrins, Topics in Current Chemistry , 161:180 273, 1991.169Sessler et al., "`Texaphyrin`: A Novel 22 π-Electron Aromatic Pentadentate Macrocyclic Ligand", ACS meeting, Los Angeles, Sep. 1988.170Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate Expanded Porphyrin Ligand", Inorg. Chem., 28:3390-3393, 1989.171Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate", Chem. Absts., 111:720, abstract No. 125716e, Oct. 2, 1989.172Sessler et al., "An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand", J. Am. Chem. Soc., 110:5586-5588, 1988.173Sessler et al., "Anion Binding: A New Direction In Porphyrin-Related Research," Pure & Applied Chem., 65(3):393-398, 1993.174Sessler et al., "Binding of Pyridine and Benzimidazole to a Cadmium Expanded Porphyrin: Solution and X-ray Structural Studies", Inorg. Chem., 28:1333-1341, 1989.175Sessler et al., "Cytosine Amine Derivatives," J. Org. Chem., 1992, 47:826-834.176Sessler et al., "Expanded Porphyrins. Receptors for Cationic, Anionic, and Neutral Substrates, in Transition Metals in Supramolecular Chemistry," L. Fabbrizzi and A. Poggi, Editors, NATO ASI Series, Kluwer, Amsterdam, pp. 391-408, 1994.177Sessler et al., "Expanded Porphyrins: The synthesis and Metal Binding Properties of Novel Tripyrrane-Containing Macrocycles", J. Coord. Chem., 18:99-104, 1988.178Sessler et al., "Gadolinium (III) Texaphyrin: A Novel MRI Contrast Agent," Journal of the American Chemical Society, 115(22):10,368-10,369, 1993.179Sessler et al., "Photodynamic Inactivation of Enveloped Viruses Using Sapphyrin, α 22 π-Electron Expanded Porphyrin: Possible Approaches to Prophylactic Blood Purification Protocols," SPIE Photodynamic Therapy: Mechanisms II. 1203:233-245, 1990.180Sessler et al., "Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy" Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.181Sessler et al., "Sapphyrins and Heterosapphyrins," Tetrahedron, 48(44):9661-9672, 1992.182Sessler et al., "Sapphyrins: New Life for an Old "Expanded Porphyrin," Synlett, 127-134, 1991.183Sessler et al., "Synthesis and Applications of Schiff-Base Derived Expanded Porphyrins," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.184Sessler et al., "Synthesis and Crystal Structure of a Novel Tripyrrane-Containing Porphyrinogen-like Macrocycle", J. Org. Chem., 52:4394-4397, 1987.185Sessler et al., "Synthesis and Structural Characterization of Lanthanide(III) Texaphyrins," Inorganic Chemistry, 32(14):3175-3187, 1993.186Sessler et al., "Texaphyrins: Synthesis and Applications," Accounts of Chemical Research, 27(2):43-50, 1994.187Sessler et al., "The Coordination Chemistry of Planar Pentadentate Porphyrin-Like Ligands", Comm. Inorg. Chem., 7:333-350, 1988.188Sessler et al., "The Synthesis and Structure of a Novel 22 π-Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Porphyrin", Toronto ACS Meeting, Jun. 1988, USA.189Sessler et al., "Tripyrroledimethine-derived (Texaphyrin-type) Macrocycles: Potential Photosensitizers Which Absorb in the Far-red Spectral Region", SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique, 1426:318-329, 1991.190 *Sessler et al., A Water Stable Gadolinium (III) Complex Derived from a New Pentadentate , Chem. Absts., 111:720, abstract No. 125716e, Oct. 2, 1989.191 *Sessler et al., A Water Stable Gadolinium (III) Complex Derived from a New Pentadentate Expanded Porphyrin Ligand , Inorg. Chem., 28:3390 3393, 1989.192 *Sessler et al., An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand , J. Am. Chem. Soc., 110:5586 5588, 1988.193 *Sessler et al., Anion Binding: A New Direction In Porphyrin Related Research, Pure & Applied Chem., 65(3):393 398, 1993.194 *Sessler et al., Binding of Pyridine and Benzimidazole to a Cadmium Expanded Porphyrin: Solution and X ray Structural Studies , Inorg. Chem., 28:1333 1341, 1989.195 *Sessler et al., Cytosine Amine Derivatives, J. Org. Chem., 1992, 47:826 834.196 *Sessler et al., Expanded Porphyrins: The synthesis and Metal Binding Properties of Novel Tripyrrane Containing Macrocycles , J. Coord. Chem., 18:99 104, 1988.197 *Sessler et al., Gadolinium (III) Texaphyrin: A Novel MRI Contrast Agent, Journal of the American Chemical Society, 115(22):10,368 10,369, 1993.198 *Sessler et al., Photodynamic Inactivation of Enveloped Viruses Using Sapphyrin, 22 Electron Expanded Porphyrin: Possible Approaches to Prophylactic Blood Purification Protocols, SPIE Photodynamic Therapy: Mechanisms II. 1203:233 245, 1990.199 *Sessler et al., Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23 28, 1992, Washington, DC.200 *Sessler et al., Synthesis and Applications of Schiff Base Derived Expanded Porphyrins, Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23 28, 1992, Washington, DC.201 *Sessler et al., Synthesis and Crystal Structure of a Novel Tripyrrane Containing Porphyrinogen like Macrocycle , J. Org. Chem., 52:4394 4397, 1987.202 *Sessler et al., Synthesis and Structural Characterization of Lanthanide(III) Texaphyrins, Inorganic Chemistry, 32(14):3175 3187, 1993.203 *Sessler et al., Texaphyrin : A Novel 22 Electron Aromatic Pentadentate Macrocyclic Ligand , ACS meeting, Los Angeles, Sep. 1988.204 *Sessler et al., Texaphyrins: Synthesis and Applications, Accounts of Chemical Research, 27(2):43 50, 1994.205 *Sessler et al., The Coordination Chemistry of Planar Pentadentate Porphyrin Like Ligands , Comm. Inorg. Chem., 7:333 350, 1988.206 *Sessler et al., The Synthesis and Structure of a Novel 22 Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Porphyrin , Toronto ACS Meeting, Jun. 1988, USA.207 *Sessler et al., Tripyrroledimethine derived (Texaphyrin type) Macrocycles: Potential Photosensitizers Which Absorb in the Far red Spectral Region , SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique, 1426:318 329, 1991.208Sessler, Jonathan L., "Texas-Sized Molecule," Discovery, 13(1):44-49, 1993.209 *Sessler, Jonathan L., Texas Sized Molecule, Discovery, 13(1):44 49, 1993.210Shelton and Morrow, "Catalytic Transesterification and Hydrolysis of RNA by Zinc(II) Complexes," Inorg. Chem., 30:4295-4299, 1991.211Shelton and Morrow, "Catalytic Transesterification and Hydrolysis of RNA by Zinc(II) Complexes," Inorganic Chemistry, 30:4295-4299, 1991.212Stern et al., "Hydrolysis of RNA by Transition-Metal Complexes," J. Am. Chem. Soc., 112:5357-5359, 1990.213Stinson, "Unusual Porphyrin Analog Promises Many Applications", Chemical and Engineering News, pp. 26-27, Aug. 8, 1988.214 *Stinson, Unusual Porphyrin Analog Promises Many Applications , Chemical and Engineering News, pp. 26 27, Aug. 8, 1988.215Strobel and Dervan, "Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA," Journal of the American Chemical Society, 111(18):7286-7287, 1989.216 *Strobel and Dervan, Cooperative Site Specific Binding of Oligonucleotides to Duplex DNA, Journal of the American Chemical Society, 111(18):7286 7287, 1989.217Sumaoka et al., "Remarkably Fast Hydrolysis of 3',5'-=Cyclic Adenosine Monophosphate by Cerium(III) Hydroxide Cluster," J. Chem. Soc. Chem. Comm., 2 pages, 1992.218T. D. Mody et al., "Lutetium (III) Texaphyrin: A Novel Photodynamic Therapy Agent," Abstract, 22nd Annual American Society for Photobiology, Scottsdale, AZ, Jun. 25-29, 1994.219 *T. D. Mody et al., Lutetium (III) Texaphyrin: A Novel Photodynamic Therapy Agent, Abstract, 22nd Annual American Society for Photobiology, Scottsdale, AZ, Jun. 25 29, 1994.220Tabushi et al., "Lipophilic Diammonium Cation Having a Rigid Structure Complementary to Pyrophosphate Dianions of Nucleotides. Selective Extraction and Transport of Nucleotides," J. Am. Chem. Soc., 1981, 103:6152-6157.221 *Tabushi et al., Lipophilic Diammonium Cation Having a Rigid Structure Complementary to Pyrophosphate Dianions of Nucleotides. Selective Extraction and Transport of Nucleotides, J. Am. Chem. Soc., 1981, 103:6152 6157.222Takasugi et al., "Sequence-Specific Photo-Induced Cross-Linking of the Two Strands of Double-Helical DNA by a Psoralen Covalently Linked to a Triple Helix-Forming Oligonucleotide," Proc. Natl. Acad. Sci. USA, 88:5602-5606, 1991.223Teare and Wollenzien, "Specificity of Site Directed Psoralen Addition to RNA," Nucleic Acids Res., 17(9):3359-3372, 1989.224 *Tentative Rules for Carbohydrate Nomenclature Part 1 (1969), Handbook of Biochemistry and Molecular Biology, 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio, pp. 100 102.225Thaller et al., "Potential Use of Radiolabelled Porphyrins for Tumor Scanning," Porphyrin Photosensitization, Kessel and Dougherty, Eds., Plenum Press, New York and London, Publisher, pp. 265-278, 1981.226 *Thaller et al., Potential Use of Radiolabelled Porphyrins for Tumor Scanning, Porphyrin Photosensitization, Kessel and Dougherty, Eds., Plenum Press, New York and London, Publisher, pp. 265 278, 1981.227To and Neiman, "The Potential For Effective Antisense Inhibition of Retroviral Replication Mediated by Retroviral Vectors,"Gene Regulation: Biology of Antisense RNA and DNA, 261-271, 1992.228Tohda et al., "Liquid Membrane Electrode for Guanosine Nucleotides Using a Cytosine-Pendant Triamine Host as the Sensory Element," Analytical Chemistry, 1992, 64(8):960-964.229 *Tohda et al., Liquid Membrane Electrode for Guanosine Nucleotides Using a Cytosine Pendant Triamine Host as the Sensory Element, Analytical Chemistry, 1992, 64(8):960 964.230Tweedle et al., "Principles of Contrast-Enhanced MRI, in Magnetic Resonance Imaging," 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793-809.231 *Tweedle et al., Principles of Contrast Enhanced MRI, in Magnetic Resonance Imaging, 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793 809.232Vlassov et al., "Photoactivatable Porphyrin Oligonucleotide Derivatives for Sequence Specific Chemical Modification and Cleavage of DNA," Nucleosides & Nucleotides, 10(1-3):641-643, 1991.233 *Vlassov et al., Photoactivatable Porphyrin Oligonucleotide Derivatives for Sequence Specific Chemical Modification and Cleavage of DNA, Nucleosides & Nucleotides, 10(1 3):641 643, 1991.234Vogel et al., "2,7,12,17-Tetrapropylporphycene-Counterpart of Octaethylporphyrin in the Porphycene Series", Angew. Chem., Int. Ed. Engl., 26:928-931, 1987.235Vogel et al., "New Porphycene Ligands: Octaethyl- and Etioporphycene (OEPc and EtioPc)-Tetra- and Pentacoordinated Zinc Complexes of OEPc," Angew. Chem. Int. Ed. Engl., 32(11):1600-1604, 1993.236Vogel et al., "Porphycene-a Novel Porphin Isomer", Angew. Chem., Int. Ed. Engl., 25:257-259, 1986.237 *Vogel et al., 2,7,12,17 Tetrapropylporphycene Counterpart of Octaethylporphyrin in the Porphycene Series , Angew. Chem., Int. Ed. Engl., 26:928 931, 1987.238 *Vogel et al., Porphycene a Novel Porphin Isomer , Angew. Chem., Int. Ed. Engl., 25:257 259, 1986.239Wagener and Beyrich, "Radiosensitizer-Biochemie und Tumortherapeutische Erfahrungen," Pharmazie, 47:815-824, 1992.240Wessel et al., "Porphyrins with Aromatic 26π-Electron Systems," Agnew. Chem. Int. Ed. Eng., 32(8):1148-1151, 1993.241Young et al., "Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex. A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging," Investigative Radiology, 29(3):330-338, 1994.242 *Young et al., Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex. A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging, Investigative Radiology, 29(3):330 338, 1994.243Zuk et al., "Pharmacokinetic and Tissue Distribution Studies of the Photosensitizer bis(Di-Isobutyl Octadecysiloxy)Silicon 2,3-Naphthalocyanine (isoBosinc) in Normal and Tumor-Bearing Rats," Photochemistry and Photobiology, 59(1):66-72, 1994.244 *Zuk et al., Pharmacokinetic and Tissue Distribution Studies of the Photosensitizer bis (Di Isobutyl Octadecysiloxy)Silicon 2,3 Naphthalocyanine ( iso Bosinc) in Normal and Tumor Bearing Rats, Photochemistry and Photobiology, 59(1):66 72, 1994.* Vom Pr�fer zitiert Referenziert von Zitiert von PatentEingetragen Ver�ffentlichungsdatum Antragsteller TitelUS5798491 *2. Juni 199525. Aug. 1998Board Of Regents, The University Of Texas SystemMulti-mechanistic chemical cleavage using certain metal complexesUS5837866 *23. Mai 199717. Nov. 1998Board Of Regents, The University Of TexasPhosphoramidite derivatives of macrocyclesUS5888997 *4. Febr. 199730. M�rz 1999Board Of Regents, The University Of Texas SystemRadiation sensitization using texaphyrinsUS5969111 *4. Febr. 199719. Okt. 1999Board Of Regents, The University Of Texas SystemTexaphyrins substituted with imidazole are providedUS6022526 *30. Juli 19978. Febr. 2000Pharmacyclics, Inc.Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanomaUS6022959 *20. Nov. 19978. Febr. 2000Pharmacyclics, Inc.Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereofUS6069140 *14. Nov. 199730. Mai 2000The Board Of Regents University Of Texas SystemPharmaceutical compositions comprising texaphyrinsUS6072038 *25. Juni 19986. Juni 2000Board Of Regents, The University Of Texas SystemConjugates of texaphyrinsUS6207660 *4. Juni 199927. M�rz 2001Jonathan L. SesslerTexaphyrin conjugates and uses thereofUS649511824. Sept. 199817. Dez. 2002Schering AktiengesellschaftLipophilic metal complexes for necrosis and infarction imagingUS663892428. Aug. 200128. Okt. 2003Pharmacyclics, Inc.Metallotexaphyrin derivativesUS672375015. M�rz 200220. Apr. 2004Allergan, Inc.Photodynamic therapy for pre-melanomasUS687880516. Aug. 200212. Apr. 2005Isis Pharmaceuticals, Inc.Peptide-conjugated oligomeric compoundsUS711267128. Aug. 200126. Sept. 2006Pharmacyclics, Inc.Non-symmetric tripyrranes in the synthesis of novel macrocyclesUS713851210. Apr. 200321. Nov. 2006Georgetown UniversityGene SHINC-2 and diagnostic and therapeutic uses thereofUS724456510. Apr. 200317. Juli 2007Georgetown UniversityGene shinc-3 and diagnostic and therapeutic uses thereofUS72532726. Okt. 20037. Aug. 2007Georgetown UniversityGene BRCC-2 and diagnostic and therapeutic uses thereofUS73518116. Okt. 20031. Apr. 2008Georgetown UniversityGene SCC-112 and diagnostic and therapeutic uses thereofUS742767522. Aug. 200523. Sept. 2008Isis Pharmaceuticals, Inc.Compounds and methods for the characterization of oligonucleotidesUS74425206. Okt. 200328. Okt. 2008Georgetown UniversityGene BRCC-3 and diagnostic and therapeutic uses thereofUS744945410. Sept. 200311. Nov. 2008Pharmacyclics, Inc.Metallotexaphyrin derivativesUS774970217. Apr. 20066. Juli 2010Epigenomics AgMethods and nucleic acids for the analyses of cellular proliferative disordersUS777174230. Apr. 200410. Aug. 2010Allergan, Inc.Sustained release intraocular implants containing tyrosine kinase inhibitors and related methodsUS77906913. Juni 20047. Sept. 2010Isis Pharmaceuticals, Inc.Double stranded compositions comprising a 3′-endo modified strand for use in gene modulationUS779933630. Apr. 200421. Sept. 2010Allergan, Inc.Hypotensive lipid-containing biodegradable intraocular implants and related methodsUS794330823. Juni 200517. Mai 2011Epigenomics AgMethods and nucleic acids for the detection of metastasis of colon cell proliferative disordersUS795156317. Apr. 200631. Mai 2011Epigenomics AgMethods and nucleic acids for analysis of cellular proliferative disordersUS799363415. Dez. 20059. Aug. 2011Allergan, Inc.Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methodsUS80300469. Okt. 20084. Okt. 2011Kineta Two, LlcMutations in OAS1 genesUS81103612. Mai 20067. Febr. 2012University of Southern California USC Stevens Center for InnovationDNA methylation markers associated with the CpG island methylator phenotype (CIMP) in human colorectal cancerUS811915430. Apr. 200421. Febr. 2012Allergan, Inc.Sustained release intraocular implants and related methodsUS813347414. Sept. 200713. M�rz 2012Massachusetts Institute Of TechnologySensors for fluorescence and magnetic resonance imagingUS814786523. Juni 20063. Apr. 2012Allergan, Inc.Steroid-containing sustained release intraocular implants and related methodsUS814834426. M�rz 20093. Apr. 2012Alnylam Pharmaceuticals, Inc.Compositions and methods for mediating RNAi in vivoUS816348823. Juni 200424. Apr. 2012Epigenomics AgMethods and nucleic acids for analysis of colon proliferative disordersUS82067368. Febr. 200826. Juni 2012Allergan, Inc.Hypotensive lipid-containing biodegradable intraocular implants and related methodsUS82067378. Febr. 200826. Juni 2012Allergan, Inc.Hypotensive lipid-containing biodegradable intraocular implants and related methodsUS825773029. Apr. 20054. Sept. 2012Allergan, Inc.Steroid-containing sustained release intraocular implants and related methodsUS826311014. Febr. 200811. Sept. 2012Allergan, Inc.Sustained release intraocular implants and related methodsUS829321029. Okt. 200723. Okt. 2012Allergan, Inc.Sustained release intraocular implants and methods for preventing retinal dysfunctionUS829857014. Febr. 200830. Okt. 2012Allergan, Inc.Sustained release intraocular implants and related methodsUS832436629. Apr. 20094. Dez. 2012Alnylam Pharmaceuticals, Inc.Compositions and methods for delivering RNAI using lipoproteinsUS840426711. Febr. 200826. M�rz 2013Allergan, Inc.Sustained release intraocular implants containing tyrosine kinase inhibitors and related methodsUS840960711. Febr. 20082. Apr. 2013Allergan, Inc.Sustained release intraocular implants containing tyrosine kinase inhibitors and related methodsUS84102633. Nov. 20092. Apr. 2013Pharmacyclics, Inc.High-purity texaphyrin metal complexesUS842592930. Apr. 200423. Apr. 2013Allergan, Inc.Sustained release intraocular implants and methods for preventing retinal dysfunctionUS844021613. Sept. 201214. Mai 2013Allergan, Inc.Sustained release intraocular implants and related methodsUS84450273. Juni 201121. Mai 2013Allergan, Inc.Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and prostamideUS845565626. Febr. 20094. Juni 2013Allergan, Inc.Kinase inhibitorsUS846577819. Juni 201218. Juni 2013Allergan, Inc.Method of making tyrosine kinase microspheresUS850698631. Jan. 200813. Aug. 2013Allergan, Inc.Sustained release intraocular implants and methods for treating ocular vasculopathiesUS851273829. Apr. 200520. Aug. 2013Allergan, Inc.Biodegradable intravitreal tyrosine kinase implantsEP1561821A213. Dez. 200410. Aug. 2005Epigenomics AGPrognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patientsEP1721992A218. Apr. 200615. Nov. 2006Epigenomics AGMethods and nucleic acids for analyses of cellular proliferative disordersEP1961827A218. Juli 200527. Aug. 2008Epigenomics AGEpigenetic methods and nucleic acids for the detection of breast cell proliferative disordersEP2045335A117. Apr. 20068. Apr. 2009Epigenomics AGMethods and nucleic acids for analyses of cellular proliferative disordersEP2083089A122. Okt. 200429. Juli 2009Illumigen Biosciences, Inc.Detection of mutations in a gene associated with resistance to viral infection, oas1EP2258871A118. Jan. 20088. Dez. 2010Epigenomics AGMethods and nucleic acids for analyses of cell proliferative disordersEP2267154A122. Okt. 200429. Dez. 2010Illumigen Biosciences, Inc.Oligoadenylate synthetaseEP2281902A118. Juli 20059. Febr. 2011Epigenomics AGEpigenetic methods and nucleic acids for the detection of breast cell proliferative disordersEP2295552A23. Mai 200616. M�rz 2011Illumigen Biosciences, Inc.Mutations in OAS1 genesEP2298932A128. Sept. 200623. M�rz 2011Epigenomics AGMethods and nucleic acids for the analysis of gene expression, in particular methylation of KAAG1, associated with tissue classificationEP2302069A111. Dez. 200830. M�rz 2011Epigenomics AGMethods and nucleic acids for analyses of cell proliferative disordersEP2305798A222. Okt. 20046. Apr. 2011Illumigen Biosciences, Inc.Detection of mutations in a gene associated with resistance to viral infection, OAS1EP2309005A12. Aug. 201013. Apr. 2011Eplgenomics AGMethods for preservation of genomic DNA sequence complexityEP2314675A23. Mai 200627. Apr. 2011Illumigen Biosciences, Inc.Mutation in OAS1 genesEP2319943A15. Nov. 201011. Mai 2011Epigenomics AGMethods of predicting therapeutic efficacy of cancer therapyEP2329830A24. Jan. 20018. Juni 2011ISIS Pharmaceuticals, Inc.Antisense inhibition of PTP1B expressionEP2330194A211. Sept. 20038. Juni 2011Replicor, Inc.Non-sequence complementary antiviral oligonucleotidesEP2345743A12. Mai 200620. Juli 2011University of Southern CaliforniaDNA methylation markers associated with the CpG island methylator phenotyp (CIMP) in human colorectal cancerEP2354249A123. Juni 200410. Aug. 2011Epigenomics AGMethods and nucleic acids for analyses of colorectal cell proliferative disordersEP2386654A12. Mai 200616. Nov. 2011University of Southern CaliforniaDNA Methylation markers associated with the CpG island methylator phenotype (cimp) in human colorectal cancerEP2395101A12. Mai 200614. Dez. 2011University of Southern CaliforniaDNA methylation markers associated with the CpG island methylator phenotype (cimp) in human colorectal cancerEP2479283A117. Apr. 200725. Juli 2012Epigenomics AGMethods and nucleic acids for the detection of colorectal cell proliferative disordersEP2484778A217. Apr. 20078. Aug. 2012Epigenomics AGMethods and nucleic acids for the detection of colorectal cell proliferative disordersWO1998050034A1 *15. Apr. 199812. Nov. 1998Light Sciences LpInternal two photon excitation device for delivery of pdt to diffuse abnormal cellsWO1999062551A1 *4. Juni 19999. Dez. 1999Pavel AnzenbacherTexaphyrin conjugates and uses thereofWO2001032211A2 *27. Okt. 200010. Mai 2001Madga DarrenConjugate compounds for treating atheroma and other diseasesWO2005035548A111. Okt. 200421. Apr. 2005Tracey Jean BrownThe moduilation of hyaluronan synthesis and degradation in the treatment of diseaseWO2005083124A130. Sept. 20049. Sept. 2005Isis Pharmaceuticals IncAntisense oligonucleotide modulation of stat3 expressionWO2006052850A2 *4. Nov. 200518. Mai 2006Wai-Fung CheongMotexafin lutetium phototherapy with low fluences for treating vascular inflammationWO2007047512A216. Okt. 200626. Apr. 2007Musc Found For Res DevInhibition of pax2 by defb1 induction as a therapy for cancerWO2009045469A21. Okt. 20089. Apr. 2009Amgen IncIncreasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereofWO2010149782A125. Juni 201029. Dez. 2010Epigenomics AgMethods and nucleic acids for analysis of bladder cell proliferative disordersWO2011094580A228. Jan. 20114. Aug. 2011Alnylam Pharmaceuticals, Inc.Chelated copper for use in the preparation of conjugated oligonucleotidesWO2011100131A228. Jan. 201118. Aug. 2011Alnylam Pharmacuticals, Inc.Monomers and oligonucleotides comprising cycloaddition adduct(s)WO2011107883A14. M�rz 20119. Sept. 2011Novartis AgAvian group d rotavirusWO2011139695A226. Apr. 201110. Nov. 2011Isis Pharmaceuticals, Inc.Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefromWO2011139699A226. Apr. 201110. Nov. 2011Isis Pharmaceuticals, Inc.5' modified nucleosides and oligomeric compounds prepared therefromWO2011163121A120. Juni 201129. Dez. 2011Alnylam Pharmaceuticals, Inc.Multifunctional copolymers for nucleic acid deliveryWO2012016188A229. Juli 20112. Febr. 2012Alnylam Pharmaceuticals, Inc.Methods and compositions for delivery of active agentsWO2012044992A230. Sept. 20115. Apr. 2012Agency For Science, Technology And Research (A*Star)Methods and reagents for detection and treatment of esophageal metaplasiaWO2012113775A121. Febr. 201230. Aug. 2012University Of ZurichAnkyrin g and modulators thereof for the treatment of neurodegenerative disordersWO2013007702A19. Juli 201217. Jan. 2013Epigenomics AgMethods and nucleic acids for determining the prognosis of a cancer subject* Vom Pr�fer zitiertKlassifizierungen US-Klassifikation514/185, 536/17.1, 536/17.3, 514/43, 514/28, 530/391.3, 534/16, 534/11, 534/13, 540/145, 514/81, 540/472, 530/391.5, 534/15, 530/345, 530/405, 540/465, 514/410, 514/44.00R, 514/19.3, 514/15.1Internationale KlassifikationA61K51/00, A61K31/407, B01J31/16, B01J31/06, A61P43/00, A61K31/40, A61P35/02, B01J31/18, C07D487/22, C07H21/00, A61K41/00, A61K47/48, A61K49/06, A61K49/00, A61K51/04, A61K49/08, A61L2/00 UnternehmensklassifikationB01J2531/842, B01J2531/96, A61K49/0021, A61K49/126, B01J2531/36, A61K49/0054, A61K41/0038, C07H21/00, C07D487/22, B01J2531/27, B01J2531/847, A61L2/0011, A61K51/0485, B01J2531/28, B01J31/061, A61K41/0076, B01J31/1815, B01J2531/23, B01J31/1805, B01J2531/38, A61K41/0057, A61K49/106, B01J2531/37, A61K49/085, B01J2531/72, B01J2531/025, A61K49/10, B01J2531/845, A61K47/48069, B01J31/1658, B01J2531/26 Europ�ische KlassifikationA61K49/00P4F8K, A61K41/00W10, A61K49/10C8, C07H21/00, A61K49/12P, B01J31/16D2, B01J31/18B, A61K49/10, A61K47/48H4H4, A61K41/00P, B01J31/18B2B, A61K49/08Z, A61L2/00P2, A61K41/00W, A61K51/04L16, A61K49/00P4F4C, C07D487/22Juristische Ereignisse DatumCodeEreignisBeschreibung30. Juni 2008REMIMaintenance fee reminder mailed24. Juni 2008FPAYFee paymentYear of fee payment: 1224. Juni 2004FPAYFee paymentYear of fee payment: 823. Juni 2000FPAYFee paymentYear of fee payment: 418. Aug. 1998CCCertificate of correctionDrehenOriginalbildGoogle-Startseite - Sitemap - USPTO-Bulk-Downloads - Datenschutzerkl�rung - Nutzungsbedingungen - �ber Google Patente - Feedback gebenDaten bereitgestellt von IFI CLAIMS Patent Services.© 2012 Google