Source: http://www.google.com/patents/US20040106989?dq=5,583,822
Timestamp: 2017-02-27 16:41:14
Document Index: 695900316

Matched Legal Cases: ['art 20', 'art 22', 'art 20', 'art 22', 'art 22', 'art 20', 'art 20', 'art 22']

Patent US20040106989 - Leaflet reinforcement for regurgitant valves - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA support, and a method for attaching said support, for providing additional strength to existing regurgitant or prolapsed valve leaflets. The support restores an otherwise non-functioning, or poorly functioning, native valve to a functioning condition, obviating the need for a complete valve removal...http://www.google.com/patents/US20040106989?utm_source=gb-gplus-sharePatent US20040106989 - Leaflet reinforcement for regurgitant valvesAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20040106989 A1Publication typeApplicationApplication numberUS 10/613,121Publication dateJun 3, 2004Filing dateJul 3, 2003Priority dateJul 3, 2002Also published asUS8348963, US20130073034Publication number10613121, 613121, US 2004/0106989 A1, US 2004/106989 A1, US 20040106989 A1, US 20040106989A1, US 2004106989 A1, US 2004106989A1, US-A1-20040106989, US-A1-2004106989, US2004/0106989A1, US2004/106989A1, US20040106989 A1, US20040106989A1, US2004106989 A1, US2004106989A1InventorsRobert Wilson, David McKinleyOriginal AssigneeWilson Robert F., Mckinley David J.Export CitationBiBTeX, EndNote, RefManPatent Citations (63), Referenced by (94), Classifications (10), Legal Events (9) External Links: USPTO, USPTO Assignment, EspacenetLeaflet reinforcement for regurgitant valves
US 20040106989 A1Abstract
A support, and a method for attaching said support, for providing additional strength to existing regurgitant or prolapsed valve leaflets. The support restores an otherwise non-functioning, or poorly functioning, native valve to a functioning condition, obviating the need for a complete valve removal or replacement. The support may also be applied to a functioning valve leaflet as a prophylactic measure against future failure. The delivery method includes a delivery mechanism for attaching the support to the native valve leaflet. Images(10) Claims(27)
BRIEF DESCRIPTION OF THE DRAWINGS [0014] [0014]FIG. 1a is a sectional view of a healthy native tricuspid valve in an open position; [0015] [0015]FIG. 1b is a sectional view of the valve of FIG. 1a taken along lines 1 b-1 b; [0016] [0016]FIG. 2a is a sectional view of a healthy tricuspid valve in a closed position; [0017] [0017]FIG. 2b is a sectional view of the valve of FIG. 2a taken along lines 2 b-2 b; [0018] [0018]FIG. 3a is a sectional view of a native prolapsed valve; [0019] [0019]FIG. 3b is a sectional view of the valve of FIG. 3a taken along lines 3 b-3 b; [0020] [0020]FIG. 4 is a perspective view of an unhinged downstream embodiment of the present invention; [0021] [0021]FIG. 5 is a perspective view of a hinged downstream embodiment of the present invention; [0022] [0022]FIG. 6 is an end view of the embodiment of FIG. 5 attached to a valve leaflet; [0023] [0023]FIG. 7 is a perspective view of a downstream hinge of the present invention; [0024] [0024]FIG. 8 is a perspective view of an unhinged upstream embodiment of the present invention; [0025] [0025]FIG. 9 is a perspective view of a hinged upstream embodiment of the present invention; [0026] [0026]FIG. 10 is a side elevation of a hinged embodiment of the present invention having members on both the upstream and downstream sides of a prolapsed leaflet; [0027] [0027]FIG. 11 is a perspective view of a substrate embodiment of the present invention in a closed position; [0028] [0028]FIG. 12 is a perspective view of a substrate embodiment of the present invention in an open position; [0029] [0029]FIG. 13 is a perspective view of a multi-member structure embodiment of the present invention; [0030] [0030]FIGS. 14a-d are a series of drawings depicting a preferred method of attaching a support to a prolapsed leaflet; [0031] [0031]FIG. 15 is an elevation of a preferred delivery device of the present invention; and, [0032] [0032]FIG. 16 is a perspective view of a preferred delivery device of the present invention.
DETAILED DESCRIPTION OF THE INVENTION [0033] Referring now to the Figures, and first to FIG. 4, there is shown unhinged embodiment of a support 10 of the present invention. Support 10 includes a support member 12, which is curved to approximately match the curve of a healthy valve leaflet in a closed position. The curve defines a convex side 14 and a concave side 16 of the support member 12. A plurality of barbs 18 extend from the support member 12, and are constructed and arranged to penetrate and catch the tissue of a prolapsed leaflet, securing the support member 12 thereto. That the barbs 18 extend from the convex side indicates that the support 10 of FIG. 4 is constructed and arranged for attachment to the downstream side of a prolapsed leaflet. [0034] The support 10 is a biocompatible material. Acceptable biocompatible metals that could be used to construct the support 10 include, but are not limited to, Nitonol, stainless steel, titanium, and other appropriate metals. Acceptable non-metal biocompatible materials include, but are not limited to, PTFE, pyrolytic carbon, or any appropriate polymer. [0035] [0035]FIG. 5 shows a hinged embodiment of a support 10. The support 10 is bifurcated into a first part 20 and a second part 22. The first part 20 and the second part 22 are connected with a hinge 24, which allows the second part 22 to rotate relative to the first part 20. Rather than the barbs 18 shown in FIG. 4, the support 10 of FIG. 5 uses a plurality of staples 26 as an attachment mechanism. FIG. 6 shows the staples 26 attaching the support 10 to a valve leaflet 3. The staples 26 are shown with a hinged embodiment 10 but there is no association between the staples 26 and the hinge 24. The barbs 18 of FIG. 4 could be used with a hinged embodiment of support 10, and vice versa. [0036] The hinge 24 is preferably designed to prevent pinching the valve leaflet 3 during operation. FIG. 7 provides a detailed view of the hinge 24. It can be seen that the hinge 24 includes a first part component 28, integral with the first part 20 and a second part component 30 integral with the second part 22. The components 28 and 30 are constructed and arranged to form an interfering stop 32 on a side opposite of the valve leaflet 3. [0037] [0037]FIG. 8 shows a support 10 constructed and arranged for attachment to an upstream side of a valve leaflet. Again, the support member 12 has a convex side 14 and a concave side 16. However, the attachment mechanism, shown as barbs 18, protrude from the concave side 16, placing the support member 12 on the upstream, convex side of the leaflet. [0038] [0038]FIG. 9 shows a hinged support 10 constructed and arranged for attachment to an upstream side of a valve leaflet. Again, the attachment mechanism, a plurality of barbs 18, protrudes from the concave side 16. The hinge 24 of the upstream, hinged embodiment includes a stop on the upstream side, so as to prevent pinching the leaflet tissue. [0039] [0039]FIG. 10 shows a support 10 that provides additional support and is less reliant on the structural integrity of the leaflet tissue for attachment purposes than the aforementioned embodiments. The support 10 includes an upstream member 32 and a downstream member 34. The upstream member 32 is attached to the downstream member 34 through the valve leaflet 3 with an attachment mechanism 36. The attachment mechanism 36 shown includes a plurality of male posts 38 that extend through and engage corresponding apertures 40 through the downstream member 34. A variety of alternatives may be effectively used as attachment mechanism 36. For example, the male posts could extend from the downstream member 34 into the upstream member 32. Each support 32 and 34 could include both posts and apertures for engaging a corresponding pattern in the opposing support. The apertures do not have to extend through to the opposite side of the defining support. Also, one or both supports could employ magnets that cause the two supports 32 and 34 to be attracted to each other across the leaflet tissue 3. [0040] The support 10 of FIG. 10 also includes a hinge assembly 42, however an unhinged two-sided support is also considered within the scope of the present invention. The hinge assembly 42 includes a single hinge 24 on the downstream member 34, which may be similar to the hinge shown in FIG. 7. The upstream member 32 includes two, or preferably three hinges 44 interconnected with connecting members 46. The connecting members 46 add length to the hinge assembly 42 such that, when the support 10 bends to an open position, the upstream and downstream members 32 and 34 do not move relative to each other. [0041] [0041]FIG. 11 shows an alternative design for a support 10 that incorporates a substrate 48. The substrate 48 is preferably a flexible, biocompatible fabric that is at least somewhat resistant to stretching and compressing. The substrate is curved around a longitudinal axis 50 to form a concave side 52 and a convex side 54. The curve is imparted to the substrate 48 using a heat, mechanical, or chemical forming process. Alternatively, or additionally, a curved brace 56 is included at one end of the support 10 that is to be placed near the base of the valve leaflet, proximal the arterial wall. [0042] Imparting a curve around the longitudinal axis 50 provides a directional strength to the support 10 that lends itself to the application of supporting a prolapsed valve leaflet. As seen in FIG. 12, when blood flows in a systolic direction, the blood pushes on the convex side 54 of the support 10 and causes the support to buckle, allowing the blood to pass through the valve. The curve does not add significant strength to the support 10 in this direction. However, when the pressure reverses, such as during diastole, the support 10 snaps back into the closed position shown in FIG. 11. Pressure against the concave side 52 is met with the resistance imparted to the support 10 by the curve, preventing the support 10 from buckling toward the convex side 54. [0043] The support 10 of FIGS. 11 and 12 is versatile enough to be placed on either or both sides of a prolapsed valve. Attachment mechanisms such as staples, permanent sutures, adhesives, magnets, or the like could be used to secure the support 10 to the valve leaflet. [0044] [0044]FIG. 13 shows another embodiment of a support 10 attached to a prolapsed valve leaflet 3. The support 10 includes a network 58 of interconnected structures 60. The structures 60 are constructed and arranged to allow the support 10 to bend in a downstream direction to an open position, yet provides resistance to bending in an upstream direction during a diastole. The support 10 may include a covering over the network 58 or the network 58 may remain open. [0045] A method of securing a support 10 to a prolapsed valve leaflet 3 is illustrated in FIGS. 14a-d. A guide wire 62 is threaded through a blood vessel 4 to the site where the support 10 is to be installed. A catheter sheath 64, containing the support 10, is then fed along the guide wire 62 until the valve 1 is reached and the support 10 is adjacent the target leaflet 3. The sheath 64 is then carefully retracted until the support 10 is exposed and free to rotate. [0046] The support 10 is attached at one end to a delivery mechanism 66, best shown in FIGS. 15 and 16. The delivery mechanism 66 is used to rotate the support 10 into place after the sheath 64 is removed. Rotation is achieved by manually pulling on activation strings 68. When the strings 68 are pulled, the delivery arms 70 rotate around axles 72 in the directions shown by arrows 74 (FIG. 14d). The support 10, being temporarily attached to the delivery arms 70, rotate therewith. It may be necessary to hold a carrier 76, on which the arms 70 are pivotally mounted, when pulling the strings 68, in order to maintain the position of the delivery mechanism 66. Once in place, the attachment mechanism of the support penetrates the leaflet, or otherwise fixes the support 10 to the leaflet, and allows the delivery arms 70 to be dislodged from the support 10. The delivery mechanism 66 and guide wire 62 are then retracted into the sheath 64 and the sheath 64 is removed from the patient. [0047] The delivery mechanism 66 is shown in FIG. 15 as delivering a support 10 that includes both an upstream member 32 and a downstream member 34. However, the same delivery mechanism 66, having two delivery arms 70, could also be used to deliver supports having only one support member, either upstream or downstream. The unused arm 70 provides a surface against which the other arm acts to secure the support to the leaflet. The unused arm also provides a surface against which staples, if used as an attachment mechanism, can be folded into an attached arrangement. [0048] The foregoing description addresses embodiments encompassing the principles of the present invention. The embodiments may be changed, modified and/or implemented using various types of arrangements. Those skilled in the art will readily recognize various modifications and changes that may be made to the invention without strictly following the exemplary embodiments and applications illustrated and described herein, and without departing from the scope of the invention, which is set forth in the following claims. 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