Source: http://www.google.com/patents/US7794965?ie=ISO-8859-1&dq=6,563,928
Timestamp: 2015-03-30 16:26:55
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Patent US7794965 - identifying a compound that modulates methylation of a protein phosphatase ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosphorylation of phosphoproteins. It relates...http://www.google.com/patents/US7794965?utm_source=gb-gplus-sharePatent US7794965 - identifying a compound that modulates methylation of a protein phosphatase that affects a protein activity and determining that the protein activity is altered by modulating with the compound methylation of the protein phosphataseAdvanced Patent SearchPublication numberUS7794965 B2Publication typeGrantApplication numberUS 10/579,369PCT numberPCT/US2003/007658Publication dateSep 14, 2010Filing dateMar 13, 2003Priority dateMar 13, 2002Fee statusLapsedAlso published asCA2477604A1, EP1483283A1, EP1483283A4, US20070031909, WO2003078448A1Publication number10579369, 579369, PCT/2003/7658, PCT/US/2003/007658, PCT/US/2003/07658, PCT/US/3/007658, PCT/US/3/07658, PCT/US2003/007658, PCT/US2003/07658, PCT/US2003007658, PCT/US200307658, PCT/US3/007658, PCT/US3/07658, PCT/US3007658, PCT/US307658, US 7794965 B2, US 7794965B2, US-B2-7794965, US7794965 B2, US7794965B2InventorsGregory Stock, Jeffry B. Stock, Maxwell Stock, Scott VafaiOriginal AssigneeSignum Biosciences, Inc., The Trustees Of Princeton UniversityExport CitationBiBTeX, EndNote, RefManPatent Citations (103), Non-Patent Citations (320), Classifications (14), Legal Events (10) External Links: USPTO, USPTO Assignment, Espacenetidentifying a compound that modulates methylation of a protein phosphatase that affects a protein activity and determining that the protein activity is altered by modulating with the compound methylation of the protein phosphatase
This invention was made with government support under Grant Number GM061284, awarded by the National Institutes of Health (�NIH�). The U.S. government has certain rights in the invention.
SAM and SAH levels were measured by high performance liquid chromatography (HPLC) according to the method described by Fu et al. in �Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine;� Biochem Biophys Res Commun 271: 47-53 (2000), which is incorporated herein by reference in its entirety particularly in parts pertinent to HPLC assays of SAM and SAH.
Combinatorial Library and HTS Screen�Okadaic Acid Scaffolds
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