Source: https://patents.google.com/patent/US20150174332A1/en
Timestamp: 2019-06-25 02:18:32
Document Index: 432926006

Matched Legal Cases: ['§371', 'Application No. 08021628', 'art 17', 'art 17', 'art 17', 'art 17', 'art 17']

US20150174332A1 - Drive mechanism for a medication delivery device and medication delivery device - Google Patents
US20150174332A1
US20150174332A1 US14/641,544 US201514641544A US2015174332A1 US 20150174332 A1 US20150174332 A1 US 20150174332A1 US 201514641544 A US201514641544 A US 201514641544A US 2015174332 A1 US2015174332 A1 US 2015174332A1
US14/641,544
US9539396B2 (en
2008-12-12 Priority to EP08021628 priority
2011-12-21 Priority to US201113133884A priority
2015-03-09 Priority to US14/641,544 priority patent/US9539396B2/en
2015-03-09 Application filed by Sanofi-Aventis Deutschland GmbH filed Critical Sanofi-Aventis Deutschland GmbH
2015-06-25 Publication of US20150174332A1 publication Critical patent/US20150174332A1/en
2016-09-16 First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44318334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20150174332(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
2017-01-10 Publication of US9539396B2 publication Critical patent/US9539396B2/en
The present application is a continuation of U.S. patent application Ser. No. 14/459,440, filed Aug. 14, 2014, which is a continuation of U.S. patent application Ser. No. 13/133,884, filed Dec. 21, 2011, which is a U.S. National Phase application pursuant to 35 U.S.C. §371 of International Application No. PCT/EP2009/066742 filed Dec. 9, 2009, which is a continuation-in-part of U.S. patent application Ser. No. 12/333,459, filed Dec. 12, 2008, now U.S. Pat. No. 8,840,591, and claims priority to European Patent Application No. 08021628.6, filed Dec. 12, 2008. The entire disclosure content of these applications is herewith incorporated by reference into the present application.
The present invention relates to a drive mechanism fir a medication delivery device and a medication delivery device incorporating such a drive mechanism.
Alternatively, the cartridge retaining member 1I may be dispensed with. It is particularly expedient, in this case, to apply a robust cartridge 4 and to attach the cartridge directly to the drive unit 3.
The term “housing” shall preferably mean any exterior housing (“main housing”, “body”, “shell”) or interior housing (“insert”, “inner body”) which may have a unidirectional axial coupling to prevent proximal movement of specific components. The housing may be designed to enable the safe, correct, and comfortable handling of the medication delivery device or any of its mechanism. Usually, it is designed to house, fix, protect, guide, and/or engage with any of the inner components of the medication delivery device (e.g., the drive mechanism, cartridge, piston, piston rod), preferably by limiting the exposure to contaminants, such as liquid, dust, dirt etc. In general, the housing may be unitary or a multipart component of tubular or non-tabular shape.
The piston rod 12 is retained in the housing 113, preferably within housing part 17. The piston rod 12 is driven in the distal direction with respect to the housing part 17 during dose delivery.
Drive member 20 is rotatable with respect to housing part 17. The drive member 20 may engage the piston rod 12. Rotational movement of the drive member, fir example rotational movement in a second direction may be converted into distal movement of the piston rod 12 with respect to the housing part 17. This is explained in more detail below.
The rotation member 21, the drive member 20, the stop member 26 and/or the dose member 34 may be or may comprise a respective sleeve. The piston rod 12 may be arranged to be driven and, in particular, may be driven through one of, more of or all of those sleeves. The piston rod 12 may run through one of more of or all of those sleeves.
The drive member 20 and the piston rod 12 are configured fir rotational movement of the drive member 20 with respect to the housing being converted into rotational movement of the piston rod with respect to the housing. The drive member 20 may engage the piston rod 12. The piston rod 12 is displaceable with respect to the drive member 20 along a displacement axis. Presently, the displacement axis runs along the rotation axis. The drive member 20 may be splined to the piston rod 12, for example.
Drive member 20 comprises an outer toothing 51. Teeth of the outer toothing 51 may extend radially away from rotation axis A. Drive member may be a toothed gear sleeve. The piston rod 12 is expediently provided with an outer toothing 52. The outer toothing 52 of piston rod 12 and the outer toothing 51 of the drive member 20 are arranged to engage one another. The outer toothing 52 of piston rod 12 and the outer toothing 51 of the drive member 20 may be permanently engaged. When the drive member 20 and the rotation member 21 rotate together in the second direction with respect to the housing 113, the piston rod 12 is also displaced in the distal direction with respect to the housing. The piston rod does not rotate while it is displaced in the distal direction with respect to the housing.
The piston rod 12 may be supported against deviation in the radial direction with respect to the displacement axis, fir example by means of housing part 17 through an opening 53 in which the piston rod may extend.
In the delivery position, drive member 20 and stop member 26 are engaged, in the reset position, drive member 20 and stop member 26 are disengaged (cf. the encircled region 59 in FIG. 17). Thus, when the clutch member 58 is in the reset position, the drive member may be rotated in the first direction with respect to the housing 13 without the stop member 26 preventing the rotation. Consequently, the piston rod 12 may be moved in the proximal direction, e.g. by rotation with respect to the housing and on account of a threaded engagement to the housing, due to the drive member 20 and the stop member 26 being disengaged.
Clutch member 58 may comprise a (additional) protrusion 62. Protrusion 62 may protrude radially and preferably inwardly from the base portion 66 of the clutch member 58. Protrusion 62 may be arranged in the region of the distal end of the clutch member 58. Protrusion. 62 may be arranged to be abuttable by and is preferably abutted by clutch resilient member 60. Clutch resilient member 60 may be supported by and, in particular, bear on a proximal face of protrusion 62.
With the (resettable) drive mechanisms described herein above a good dose accuracy may be achieved. The drive mechanisms are particularly suitable for dispensing doses of the medication from and including 1 IU up to and including 30 IU, (preferably from and including 3 IU up to and including 20 IU. Also, doses of 30 IU or more or 1 IU or less may be dispensed by means of the described drive mechanisms. However, doses of from and including 1 IU up to and including 30 IU are particularly suitable. For example, if a device described in conjunction with FIGS. 1 to 10, in which the piston rod rotates during displacement, was to be designed for doses less than 1 IU, the thread of the piston rod should have a low pitch and/or the number of teeth of the respective toothing of drive member and rotation member should be increased. Of course, the production costs may increase on account of the finer segmentation of the toothings and the lower pitch thread. In order to provide for a device configured to deliver doses greater than 30 IU, e.g. 50 IU or greater, the thread in the piston rod should have a higher pitch. Consequently, small deviations from a predetermined course of the thread result in major absolute deviations from the desired dose. Thus, the risk of a reduction in dose accuracy may be increased. In addition, the risk of self-locking of a threaded engagement may be increased.
An eighth aspect provides a drive mechanism according to any of the second through sixth aspects, wherein the dose member (16, 34, 41) and the rotation member (21) are coupled to one another by a lever (55), the lever being pivotally around the rotation axis during movement of the dose member thr setting and delivery of the dose.
1. A drive mechanism for a medication delivery device, comprising:
a rotation member which is adapted to be rotated in a first direction with respect to the housing during setting of a dose of a medication and to be rotated in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction,
a piston rod which is adapted to be displaced in a distal direction with respect to the housing for delivering the dose,
a drive member which follows rotational movement of the rotation member in the second direction during delivery of the dose, and
a stop member which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose, wherein
the rotational movement of the drive member in the second direction is converted into movement of the piston rod in the distal direction with respect to the housing,
wherein the drive member abuts the rotation member during movement of the rotation member for setting and delivery of the dose.
US14/641,544 2008-12-12 2015-03-09 Drive mechanism for a medication delivery device and medication delivery device Active US9539396B2 (en)
EP08021628 2008-12-12
US201113133884A true 2011-12-21 2011-12-21
US14/459,440 Continuation US9750888B2 (en) 2008-12-12 2014-08-14 Drive mechanism for a medication delivery device and medication delivery device
US14/858,102 Continuation US9457152B2 (en) 2008-12-12 2015-09-18 Drive mechanism for a medication delivery device and medication delivery device
US20150174332A1 true US20150174332A1 (en) 2015-06-25
US9539396B2 US9539396B2 (en) 2017-01-10
US12/333,459 Active 2031-07-05 US8840591B2 (en) 2008-12-12 2008-12-12 Drive mechanism for a medication delivery device and medication delivery device
US14/641,544 Active US9539396B2 (en) 2008-12-12 2015-03-09 Drive mechanism for a medication delivery device and medication delivery device
US14/858,102 Active US9457152B2 (en) 2008-12-12 2015-09-18 Drive mechanism for a medication delivery device and medication delivery device
US20140316348A1 (en) 2014-10-23 Drive mechanisms suitable for use in drug delivery devices