Source: https://patents.google.com/patent/EP1532936A1/en
Timestamp: 2019-02-19 04:59:05
Document Index: 520263349

Matched Legal Cases: ['art 4', 'art 10', 'art 10', 'art 2', 'art 10', 'art 2', 'art 4', 'art 7', 'art 7', 'art 7', 'art 7', 'art 20', 'art 21', 'art 21', 'art 20', 'art 7', 'art 7', 'art 7', 'art 7', 'art 7', 'art 50', 'art 31', 'art 30', 'art 10', 'art 7', 'art 50', 'art 10', 'art 2', 'art 10', 'art 50', 'art 7', 'art 7', 'art 50', 'art 7', 'art 4', 'art 10', 'art 4', 'art 7', 'art 4', 'art 4', 'art 4', 'art 40', 'art 4', 'art 4', 'art 4', 'art 35', 'art 35', 'art 4', 'art 53', 'art 58', 'art 53', 'art 58', 'art 35', 'art 4', 'art 53', 'art 10', 'art 53', 'art 20', 'art 53', 'art 7', 'art 7', 'art 4', 'art 53', 'art 53', 'art 4', 'art 35', 'art 58', 'art 53', 'art 58', 'art 35', 'art 4', 'art 7', 'art 60', 'art 62', 'art 20', 'art 7', 'art 7', 'art 7', 'art 7', 'art 7', 'art 72', 'art 73', 'art 72', 'art 73', 'art 7', 'art 72', 'art 73', 'art 7', 'art 7', 'art 70', 'art 74', 'art 20', 'art 52', 'art 7', 'art 51', 'art 51', 'art 20']

EP1532936A1 - Laser induced liquid jet generating apparatus - Google Patents
Laser induced liquid jet generating apparatus Download PDF
EP1532936A1
EP1532936A1 EP04027428A EP04027428A EP1532936A1 EP 1532936 A1 EP1532936 A1 EP 1532936A1 EP 04027428 A EP04027428 A EP 04027428A EP 04027428 A EP04027428 A EP 04027428A EP 1532936 A1 EP1532936 A1 EP 1532936A1
EP04027428A
EP1532936B1 (en
Takeshi Terumo K.K. Kanamaru
Hideshi Terumo K.K. Obitsu
Shigeru Terumo K.K. Omori
2003-11-21 Priority to JP2003392133 priority
2003-11-21 Priority to JP2003392130 priority
2004-11-18 Application filed by Terumo Corp filed Critical Terumo Corp
2005-05-25 Publication of EP1532936A1 publication Critical patent/EP1532936A1/en
2008-06-11 Publication of EP1532936B1 publication Critical patent/EP1532936B1/en
This application is based upon Japanese Patent Applications No. 2003-392130 and No. 2003-392133 filed November 21, 2003 the contents of which are hereby incorporated by reference.
The official gazette of JP-A-2003-111766, WO00/04838 (the official gazette of International Unexamined Patent Publication No. 2002-521084), and THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, Vol. 22, No. 3(2001) (refer to page 217) describe a technique which comprises guiding a laser in a pulsating form from a laser oscillator into an optical fiber inserted in a catheter, abruptly heating a physiological saline filling the catheter interior and inducing a liquid jet flow, and shattering and removing the thrombosis by dint of the liquid jet flow.
The apparatus contemplated by this invention shuns irradiation of a laser beam in a slender and narrow catheter, irradiates the laser beam in a large spatial part forming the interior of a main body, and introduces the generated liquid jet flow through a nozzle into a catheter. Consequently, it allows use of a slender catheter, avoids being thermally affectedby the laser beam, attains irradiation of as powerful laser beam as possible, permits a protracted use, and realizes a smooth operation. As a result, it is capable of infallibly shattering the target object such as the thrombus very powerfully.
To the terminal wall 5 of the spatial part 4, the optical fiber fitting part 10 is connected. The optical fiber fitting part 10 comprises the tubular ferrule 11 provided in the interior thereof with a slender passage for allowing insertion of the optical fiber 7 therethrough, an engaging member 12 disposed integrally at the intermediate position of the ferrule 11, and a female screw cap 15 for engaging a flange 13 of the engaging member 12 and an engaging piece 15a. The female screw cap 15 is helically joined with a male screw projecting part 2a on the laser oscillator 2 side. By this helical union, the optical fiber fitting part 10 is fixed to the laser oscillator 2. Incidentally, the optical fiber 7 (indicated by a broken line in Fig. 1) is also retained as fixed in position by the helical union between the female screw cap 15 and the screw projecting part 2a. Optionally, it may be provided with a separate optical fiber fixing part.
The leading terminal side of the ferrule 11 is inserted through the terminal wall 5 and projected into the spatial part 4. The optical fiber 7 is inserted into and fixed in the ferrule 11. The leading terminal of the optical fiber 7, namely a laser irradiating part 7a, is projected out of the ferrule 11 and adapted to irradiate therefrom in a pulsated form a laser of a wavelength easy to be absorbedbya liquidW. The outer periphery of the laser irradiating part 7a is preferred to be coated with a thin metallic film 8 as by plating means with a view to enhancing the mechanical strength of a laser irradiating part 7a itself and exalting the durability thereof.
Though the laser irradiated from the laser irradiating part 7a possesses the property of producing rectilinear propagation, it is permissible to form a light reflecting layer (not shown) which is capable of reflecting a laser beam. By forming the light reflecting layer of this nature, it is made possible to prevent the irradiated laser beam from being absorbed by the main body, exalt the efficiency of utilization of the laser beam, and consequently heighten the powerfulness of the liquid jet flow. This light reflecting layer is formed by treating the inner surface of the main body 3. As preferred examples of the method for the treatment of the inner surface, the coating by the DLC (diamond like carbon), the ceramic coating, and the coating with gold or silver may be cited.
The liquid injecting part 20 contemplated by the present embodiment is a tubular member provided in the interior thereof with a passage for allowing flow of the liquid W therethrough and having a terminal part thereof transformed by the formation of a screw thread into a connecting part 21. A tube 8 is connected to the connecting part 21 and adapted to have the prescribed liquid W injected therein by means of a syringe pump (not shown). The position of the liquid injecting part 20 is preferred to be such that the liquid W may be directed toward the laser irradiating part 7a of the optical fiber 7 and the laser irradiating part 7a consequently may be infallibly cooled. It is further preferred to be more directed toward the rear terminal side than the laser irradiating part 7a at the leading terminal of the ferrule 11, namely toward the terminal wall 5 side, as shown in Fig. 2. So long as the position is such as this, the laser irradiating part 7a is infallibly cooled because the liquid W flows out while it keeps contact with the laser irradiating part 7a.
Since the Y connector part 50 is a device already well known, a detailed description thereof will be omitted. It is furnished in the interior thereof with a tubular elastic body and is provided with a compressing member for deforming the elastic body by compression and provided further with a first port 50a and a second port 50b which respectively communicate with the ambience. A guide wire G is inserted into the first port 50a. The guide wire G is watertightly fixed by deforming the elastic body in the first port 50a by compression. The catheter 9 is watertightly connected to the other terminal part of the first port 50a. The second port 50b is watertightly connected to a connecting part 31 produced by forming a screw thread in the terminal part 30 of the main body 3.
The nozzle 6 is positioned opposite the optical fiber fitting part 10 which is provided for the main body 3. This is because the power of the liquid jet flow J generated in the laser irradiating part 7a is required to be guided easily into the catheter 9 through the medium of the Y connector part 50.
The materialpossessing flexibility andstrength,for example, is a HDPE (high density polyethylene) monolayer or a LLDPE (linear low density polyethylene) bilayer. Not only these but also polyolefins such as polyvinyl chloride, polyethylene, polypropylene, ethylene-propylene copolymer, and ethylene-vinyl acetate copolymer, polyesters such as polyethylene terephthalate and polybutylene terephthalate, various thermoplastic resins and thermosetting resins such as polystyrene, polyurethane, polyamide, polyimide, polyoxymethylene, polyvinyl alcohol, polytetrafluoroethylene, polyvinylidene fluoride, and other fluorine type resins, thermoplastic elastomers such as polyamide elastomer and polyester elastomers, and various rubbers such as silicone rubber and latex rubber are available.
First, the artisan fixes the main body 3 by helically joining the female screw cap15 of the optical fiber fitting part 10 having the optical fiber 7 inserted in advance in the ferrule 11 thereof and the screw projecting part 2a thereby fixing the optical fiber fitting part 10 to the laser oscillator 2.
In the state, the artisan inserts the guide wire G through the first port 50a of the Y connector part 50 and, when the distal end thereof reaches the site of a thrombus, keeps the guide wire G at that position. Then, he inserts the catheter 9 into the blood vessel with the guide wire G as the guide. In this case, when he has the catheter 9 in advance provided at the distal end portion thereof with a radiopaque material (such as, for example, gold, silver, platinum, tungsten, palladium, or alloys thereof) as a so-called marker, he is enabled to insert the catheter 9 while he keeps the position of the marker confirmed as by radiation of X rays. Thus, he is allowed to comprehend the position of the catheter 9 exactly in the live human body.
When the distal end of the catheter 9 reaches the prescribed side in the blood vessel, he extracts the guide wire G from the catheter 9. When he then sets the laser oscillator 2 operating, the pulsated laser beam is irradiated from the laser irradiating part 7a at the leading terminal of the optical fiber toward the liquid W.
In this embodiment, since the laser irradiating part 7a at the leading terminal of the ferrule 11 is positioned opposite the nozzle 6, the produced liquid jet flow J is promptly spouted through the nozzle 6 of the main body 3 and directed toward the catheter 9 through the first port 50a of the Y connector part 50.
The second embodiment, because of the ability to carry out the inj ection and the discharge of the liquid W independently without requiring replacement of the pump or the liquid injecting tube 8, is enabled to enhance the efficiency of operation, smoothen the flow of the liquid W in the main body 3, increase the flow volume of the liquid W as well, and consequently exalt the effect of cooling the laser irradiating part 7a.
In the first and second embodiments, the spatial part 4 of the main body 3 has an inner wall surface 4a thereof formed nearly straight from the optical fiber fitting part 10 toward the nozzle 6. The inner wall surface 4a may be alternatively formed as tapered so that the inner diameter of the spatial part 4 decreases toward the leading terminal as shown in Fig. 5.
By thus tapering the inner wall surface 4a, the speed of flow of the liquid jet J induced by the laser irradiating part 7a is further heightened by the tapered spatial part 4 and the shattering is attained more powerfully. Moreover, when the spatial part 4 is in the tapered shape, it constitutes a guide and enables the power of the liquid jet flow to be smoothly introduced into the catheter 9.
In other words, the present apparatus comprises a first main body (main body 3) and a second main body (Y connector 53) capable of being connected to the rear terminal part of the first main body. The first main body (main body 3) is possessed of a first spatial part 4 formed in the interior thereof, a liquid discharging part 40 communicating with the spatial part 4 and used for discharging the liquid in the spatial part 4, a nozzle 6 disposed in the leading terminal part of the first main body (main body 3) and spouting the liquid in the spatial part 4 to the exterior of the first main body (main body 3), and a first connecting part 35 disposed in the rear terminal part of the first main body (main body 3) and furnished with a first opening part 35a communicating with the first spatial part 4.
The second main body (Y connector 53) is furnished with a second spatial part 53a formed therein and a second opening part 58a disposed at the leading terminal part of the second main body (Y connector 53) and communicating with the spatial part 53a and is possessed of a second connecting part 58 (coupler) capable of being connected to the first connecting part 35 in a state allowing communication between the first spatial part 4 and the second spatial part 53, an optical fiber fitting part 10 disposed in a state capable of communicating with the spatial part 53a, and a liquid injecting part 20 for injection the liquid W into the spatial part 53a.
The apparatus will be described in further detail below. The members fulfilling the same functions as shown in Figs. 1 - 4 will be denoted by the same referential numerals and the explanation thereof will be omitted.
The laser irradiating part 7a in the leading terminal part of the optical fiber 7 is disposed in the neighborhood of the discharge passage T1. This neighborhood is provided with a reinforcing member, specifically a metallic partitioning tube 59, which is formed of a material having a high melting point enough to with stand the heat emitted by the optical fiber 7 and possessing as well prescribed stiffness. The partitioning tube 59 is possessed of the function of efficiently spouting the liquid jet flow J of bubble B generated by the laser irradiating part 7a through the nozzle 6 of the first main body (main body 3), the function of dividing the flow path of the liquid jet flow J and the flow path for allowing flow of the liquid W aspirated by the discharge passage T1, and the function of protecting and reinforcing the inner wall surface of the first spatial part 4. The partitioning tube 59, therefore, is preferred to be elongated more toward the nozzle 6 side than the basal part of the discharge passage T1.
The partitioning tube 59, however, is preferred to be so constructed that a proper gap may occur between the outer surface of the partitioning tube 59 and the basal part of the discharge passage T1 lest the elongation of the partitioning tube 59 should interfere with the flow of the liquid W into the discharge passage T1. The partitioning tube 59 is further preferred to be provided on the inner surface thereof with a reflecting layer 59a capable of reflecting the laser beam issued from the optical fiber 7.
Meanwhile, the second main body (Y connector 53) integrally communicates with the second spatial part 53a mentioned above and has formed therein a fiber passage 54 for selectively allowing the optical fiber 7 and the guide wire G to be inserted therethrough and a liquid injection passage T2 for supplying the liquid W. These two passages 54 and T2 intersect each other at a prescribed angle and form a confluence in the second spatial part 53a and communicate with the first spatial part 4 of the first main body (main body 3) through the medium of the opening part 35a.
A liquid feeding pump KP, specifically a syringe pump (refer to Fig. 6) , is connected to the liquid injection passage T2. Then, the first main body (main body 3) and the secondmain body (Y connector 53) are connected to each other by means of a screw type second connecting part 58 (coupler) through the medium of an O-ring O.
He inserts the guide wire G into the fiber passage 54. He inserts the guide wire G inside the catheter 9 via the second spatial part 53a, the opening part 58a of the first connecting part 35, the first spatial part 4, and the nozzle 6 till it protrudes from the distal end of the catheter 9.
While the supply and the suction of the liquidWby the operation of the two pumps are alternately performed, they are preferred to be performed intermittently. The amount of supply and the amount of suction of the liquid W are equal and fall in the range of 1.0 ml/min ∼ 15.0 ml/min, for example. In this embodiment, the two flows can be infallibly generated because the flow of the liquid jet J from the laser irradiating part 7a and the flow of the liquid W to be suctioned are divided by the partitioning tube 59.
Particularly in this embodiment, since the laser irradiation is effected in the partitioning tube 59, the liquid jet J do not decrease its power because it is restricted from being diffused outwardly and is efficiently spouted through the nozzle 6 of the firstmainbody (main body 3). The inner surface of the partitioning tube 59 is fated to be exposed to the high heat and the pressing power due to the sudden generation of bubble B. In this embodiment, however, the prescribed performance can be retained for a long time because of the use of the partitioning tube 59 made of a metal or the like.
In the preceding embodiment, the insertion of a catheter resort solely to a guide wire as a guide. Optionally, the catheter may use a wire guide and a thick tube (hereinafter referred to collectively as "a guiding catheter").
When a fine blood vessel diverges from a thick blood vessel, therefore, the guiding catheter is inserted to the branch point and thereafter a fine catheter (which corresponds to the catheter 9 in the preceding embodiment and will be referred to hereinafter as "a micro-catheter") is inserted into the guiding catheter with the guide wire G as a guide. In the state, the micro-catheter is inserted into the fine blood vessel either as guided by the guide wire G or by itself. In this manner, the convenience obtained in inserting the micro-catheter to the fine cerebral blood vessel is exalted and the technique of the insertion is smoothed.
This embodiment is illustrated in Fig. 8 and Fig. 9. In these diagrams, the members fulfilling the same functions as shown in Fig. 1 - Fig. 7 are denoted by the same reference numerals and their explanation will be omitted here.
The Y connector 60 is provided with a fiber passing part 60c allowing insertion therethrough of the optical fiber 7 guiding the laser beam from the laser oscillator 2 and retaining the optical fiber 7 at a fixed position and a passage 60a having connected thereto a pump P fulfilling the function of filling the micro-catheter Mc with the liquid W and the function of aspirating the liquid W which has contained the shattered thrombus.
The Y connector 62 is provided with a catheter retaining part 62c possessed of an elastically compressive deformed body watertightly fixing the micro-catheter Mc inserted in the interior thereof and a liquid injecting part 20 for injecting the liquid W by the syringe pump Kp to the interior of the guiding catheter Gc, namely to the gap between the micro-catheter Mc and the guiding catheter Gc.
The micro-catheter Mc having the optical fiber 7 inserted therein is passed through the interiors of the Y connector 62, the hub 63, and the guiding catheter Gc and extended to the distal end of the guiding catheter Gc. The micro-catheter Mc is provided in the neighborhood of the distal end portion thereof with the laser irradiating part 7a for emitting a laser beam. Incidentally, the micro-catheter Mc is preferred to be such that the portion thereof extending from the proximal part connected to the hub 61 to the laser irradiating part 7a possesses comparatively high stiffness from the viewpoint of efficiency of operation, and the portion thereof extending from the laser irradiating part 7a to the distal end portion constitutes a flexible distal part 7b for the purpose of preventing itself from inflicting a scratch on the inner surface of the blood vessel during the insertion into the patient's body.
The laser irradiating part 7a is provided in a reinforcing member 71 on the inner surface of the micro-catheter Mc and consequently enabled to prevent the comparatively soft micro-catheter Mc from being directly affected by high temperature and the pressing power induced by the generation of the bubble B. The reinforcing member 71 may be made of any high melting material which is capable of fitting the inner surface of the micro-catheter Mc and withstanding the heat of the laser beam. Commendably, it is a metallic sleeve of stainless steel, tungsten, nickel, or Inconel®, for example. Preferably, the reinforcing member 71 is possessed of a radiopaque marker impervious to the X rays.
The reinforcing member 71 has a stepped part 72 and a projecting part 73 formed at the leading terminal thereof. The stepped part 72 is meant as a stopper during the insertion of the optical fiber 7 into the micro-catheter Mc and the projecting part 73 is meant as a connecting part for the flexible distal part 7b. In the insertion of the optical fiber 7 into the micro-catheter Mc, the irradiating position can be confirmed by obtaining a sensation of the collision of the leading terminal against the stepped part 72. The presence of the projecting part 73 results in facilitating the work of connecting the soft distal part 7b and enabling an artisan to enjoy exaltation of the convenience and the practical effect.
When the laser oscillator 2 is actuated, the pulsated laser beam is passed through the optical fiber 7 and irradiated on the liquid W. The irradiation is effected in the reinforcing member 71, the liquid W is suddenly heated by the pulsated laser beam and the bubble B is intermittently generated. At the result, the liquid w in the reinforcing member 71 is suddenly spouted through the outlet of the reinforcing member 71 and intermittently emitted in the form of the so-called liquid jet J through the soft distal part 7b. Since the check valve 75 checks the outflow of the liquid jet J toward the guiding catheter Gc, the bubble B are prevented from guided from the opening part 70 and the opening part 74 toward the guiding catheter Gc side so that the power of the liquid jet cannot be allayed.
At the same time, the artisan continues to aspirate the liquid W through the passage 60a by the pump P and inject the liquid W through the liquid injecting part 20. Consequently, a flow occurs in the direction opposite the liquid jet J and the shattered thrombus is aspirated together with the blood through the distal side of the micro-catheter Mc.
Now, modified examples of the reinforcing member 71 will be explained as the seventh - 10th embodiment below. The same component members as shown in the preceding embodiment mentioned above will be denoted by the same reference numerals and their explanation will be omitted.
The reinforcing member 71 contemplated by the preceding embodiment is disposed on the inner surface of the micro-catheter Mc. Since the reinforcing member 71 in this embodiment is required to possess a highmelting point enough to withstand the heat generated by the optical fiber 7 and exhibit prescribed stiffness, it assumes the shape of a protective film layer 77 formed directly on the inner surface of the micro-catheter Mc as illustrated in Fig. 13.
The coiled member 78 is specifically formed by winding a stainless steel ribbon or piano wire having a thickness or a diameter in the range of 0.001 mm - 0.5 mm in the shape of a coil encircling an empty space. It may be formed wholly or partially of an X-ray impervious material so as to function as an X-ray shadowing marker. The leading terminal of the coiled member 78 or part of the coil thereof may be radially converged so that the coiled member 78 may function as a stopper against which the leading terminal part of the optical fiber 7 mentioned above collides. Further, the micro-catheter Mc may be provided in the stiff proximal part thereof with the coiled member 78 so as to impart relatively high stiffness to the micro-catheter Mc and heighten the efficiency of operation thereof. That is, the whole micro-catheter Mc extending from the nearby operating part 52 through the laser irradiating part 7a may be provided with the coiled member 78. This construction, during the course of manipulation, enables the nearby operating part 51 and the micro-catheter Mc to resist such external powers as displacement and torsion in the direction perpendicular to the axis which are exerted thereon, prevents the catheter from being bent or fractured either wholly or to an extent of repression, and precludes the micro-catheter Mc from giving rise to a kink or fracture.
In Fig. 15 and Fig. 16, a micro-catheter Mc' according to the eleventh embodiment has a passage M1 and a passage M2 formed in the interior thereof. The optical fiber 7 is inserted in the passage M1 and the guide wire G is inserted in the passage M2. The guide wire G is used till the distal end of the micro-catheter Mc' reaches the prescribed position in the blood vessel and subsequently extracted from the passage M2.
The nearby operating part 51, as illustrated in Fig. 17, uses a joint member 80 in the place of the Y connector 51 shown in Fig. 8. The joint member 80 is intended to establish connection between the Y-shaped adapter 60 and the micro-catheter Mc' and is provided in the interior thereof with two cylindrical tubes 90 and 91.
The tube 90 tightly connects the Y-shaped adapter 60 and the micro-catheter Mc', effects the inflow of the liquid W into the passage M1 by means of the syringe pump Kp disposed in the liquid injecting part 20 of the Y-shaped adapter 62, and guides the liquid to the distal end portion of the micro-catheter Mc'.
The tube 91 tightly connects a suction inlet 92 and the micro-catheter Mc' and fulfills the function of filling the micro-catheter Mc' with the liquid W by means of the pump P and the function of aspirating the liquid W containing the shattered thrombus, for example.
By forming the passage for the supply of the liquid W and the passage for the recovery of the thrombus in one micro-catheter Mc' as described above, it is made possible to form the catheter in a smaller diameter and allow the burden to be imposed in a smaller amount on the human body than when the tube for the recovery of the target substance is provided separately.
A laser induced liquid jet generating apparatus comprising:
a nozzle for spouting a liquid jet generatedby the irradiation of said laser beam toward said liquid to the exterior of said main body,
An apparatus according to claim 1, wherein said main body has said liquid injecting part so disposed as to direct said liquid toward the laser irradiating part of said optical fiber.
An apparatus according to claim 1, wherein said main body is provided with a liquid discharging part for discharging said liquid to the exterior of said main body.
An apparatus according to claim 1, wherein said main body is disposed at such a position as to oppose the leading terminal part of said optical fiber fitting part and the nozzle to each other.
An apparatus according to claim 4, wherein said main body has the inner wall surface of said spatial part so formed as to be tapered to decrease the inner diameter of said spatial part from the optical fiber fitting part side toward the nozzle.
An apparatus according to claim 1, wherein said main body is formed of a material having a high melting point enough to withstand the heat generated by said optical fiber and possessing stiffness as well.
An apparatus according to claim 6, wherein the material of said main body is a metal.
An apparatus according to claim 1, wherein said main body has the inner wall surface of said spatial part provided with a reflecting layer capable of reflecting the laser beam emitted from the laser irradiating part of said optical fiber.
An apparatus according to claim 1, wherein said spatial part in the neighborhood of the position for irradiating the laser beam from at least said optical fiber is provided with a reinforcing member formed of a material having a high melting point enough to withstand the heat generated by said optical fiber and possessing stiffness as well.
An apparatus according to claim 9, wherein said reinforcing member is provided on the inner surface thereof with a reflecting layer capable of reflecting the laser beam emitted from said optical fiber.
An apparatus according to claim 1, wherein said main body is possessed of a first main body and a second main body capable of being connected to the rear terminal part of said first main body,
An apparatus according to claim 11, wherein said main body is furnished in said first spatial part with a partition tube having the interior thereof communicating with said first opening of said first connecting part and allowing insertion therein of an optical fiber attached to said optical fiber fitting part.
An apparatus according to claim 12, wherein said partitioning tube is extended more toward said nozzle than the basal part of said liquid discharging part.
An apparatus according to claim 12, wherein said partitioning tube is formed of a material having a high melting point enough to withstand the heat generated by said optical fiber and possessing prescribed stiffness as well.
EP04027428A 2003-11-21 2004-11-18 Laser induced liquid jet generating apparatus Active EP1532936B1 (en)
JP2003392133 2003-11-21
EP1532936A1 true EP1532936A1 (en) 2005-05-25
EP1532936B1 EP1532936B1 (en) 2008-06-11
EP04027428A Active EP1532936B1 (en) 2003-11-21 2004-11-18 Laser induced liquid jet generating apparatus
US20050124985A1 (en) 2005-06-09
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