Source: http://www.science.gov/topicpages/a/administration+osha+regulations.html
Timestamp: 2016-10-28 21:39:22
Document Index: 333799938

Matched Legal Cases: ['art 667', 'art 215', 'arts 95', 'art 37', 'arts 736', 'arts 730']

administration osha regulations: Topics by Science.gov
Sample records for administration osha regulations
78 FR 43972 - Amendments to the Export Administration Regulations: Implementation of Limited Syria Waiver for...
...). See 69 FR 26766 (May 14, 2004). In addition, BIS later made administrative changes to General Order No.... See 74 FR 77115 (Dec. 12, 2011). On June 12, 2013, the Secretary of State exercised authority..., 2001 (3 CFR, 2001 Comp., p. 783 (2002)), as amended by Executive Order 13637 of March 8, 2013, 78...
Zanos, Panos; Georgiou, Polymnia; Metaxas, Athanasios; Kitchen, Ian; Winsky-Sommerer, Raphaelle; Bailey, Alexis
Nicotine addiction is considered to be the main preventable cause of death worldwide. While growing evidence indicates that the neurohypophysial peptide oxytocin can modulate the addictive properties of several abused drugs, the regulation of the oxytocinergic system following nicotine administration has so far received little attention. Here, we examined the effects of long-term nicotine or saline administration on the central oxytocinergic system using [(125)I]OVTA autoradiographic binding in mouse brain. Male, 7-week old C57BL6J mice were treated with either nicotine (7.8 mg/kg daily; rate of 0.5 μl per hour) or saline for a period of 14-days via osmotic minipumps. Chronic nicotine administration induced a marked region-specific upregulation of the oxytocin receptor binding in the amygdala, a brain region involved in stress and emotional regulation. These results provide direct evidence for nicotine-induced neuroadaptations in the oxytocinergic system, which may be involved in the modulation of nicotine-seeking as well as emotional consequence of chronic drug use. PMID:26037668
76 FR 58393 - Updated Statements of Legal Authority for the Export Administration Regulations
... notice of August 12, 2011--Continuation of Emergency Regarding Export Control Regulations (76 FR 50661... FR 15825, 3 CFR, 1976 Comp., p. 114; E.O. 12002, 42 FR 35623, 3 CFR, 1977 Comp., p. 133; E.O. 12058, 43 FR 20947, 3 CFR, 1978 Comp., p. 179; E.O. 12214, 45 FR 29783, 3 CFR, 1980 Comp., p. 256;...
15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).
... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... export control jurisdiction of the Bureau of Industry and Security, U.S. Department of Commerce....
... Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... of the Bureau of Industry and Security, U.S. Department of Commerce. Note that certain...
20 CFR 672.500 - What administrative regulations apply to the YouthBuild program?
... requirements found in 20 CFR part 667, except those that apply only to the WIA Title I-B program and those that... grants requirements: Circular A-110 (codified at 2 CFR part 215), and Circular A-102 at 29 CFR parts 95 and 97, as applicable; (2) The Department's regulations at 29 CFR part 37, which implement...
77 FR 71099 - Federal Housing Administration (FHA): Temporary Waiver of FHA's Regulation on Property Flipping...
... mortgages insured by FHA, HUD issued a final rule on May 1, 2003 (68 FR 23370) that provides in 24 CFR 203... final rule published on June 7, 2006 (71 FR 33138), HUD expanded the exemptions to the 90-day time... Register on May 21, 2010, at 75 FR 28633. The May 2010 notice waived HUD's regulations through December...
75 FR 28632 - Federal Housing Administration (FHA)-Temporary Exemption From Compliance With FHA's Regulation on...
... practice with respect to mortgages insured by FHA, HUD issued a final rule on May 1, 2003 (68 FR 23370... are specified in Sec. 203.37a(c). In a final rule published on June 7, 2006 (71 FR 33138), HUD... Compliance With FHA's Regulation on Property Flipping AGENCY: Office of the Assistant Secretary for...
... 746 of the EAR with respect to Syria is based in part on Executive Order 13338, 69 FR 26751, 3 CFR... Actions of the Government of Syria, 77 FR 27559 (May 10, 2012), which is the most recent such annual... August 15, 2012--Continuation of Emergency Regarding Export Control Regulations, 77 FR 49699 (August...
... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C..., responsible for reviewing applications to export and reexport items on the U.S. Munitions List. (See 22 CFR... Office of Foreign Assets Control (see 31 CFR chapter V). Forwarding agent. The person in the...
75 FR 53864 - Updated Statements of Legal Authority for the Export Administration Regulations
... Regarding Export Control Regulations (74 FR 50681, August 16, 2010), which is the most recent such annual..., Inventions and patents, Research, Science and technology. 15 CFR Parts 736, 738, 770, and 772 Exports. 15 CFR... recordkeeping requirements, Science and technology. 0 Accordingly, parts 730, 732, 734, 736, 738, 740, 742,...
Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho
Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration. PMID:25820086
76 FR 77115 - Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding...
... that of August 12, 2011 (76 FR 50,661 (Aug. 16, 2011)), has continued the Regulations in effect under.... 13026, 61 FR 58767, 3 CFR, 1996 Comp., p. 228; E.O. 13222, 66 FR 44025, 3 CFR, 2001 Comp., p. 783; Notice of August 12, 2011 (76 FR 50661 (Aug. 16, 2011)). Sec. 732.1 0 2. Section 732.1 is amended by: 0...
Hattangadi, Jona A.; O'Reilly, James T.; Recht, Abram
Although radiation therapy is highly safe and effective in treating cancer, recent reports of dangerous radiation-related errors have focused a national spotlight on the field of radiation oncology and, more specifically, on the rapidly evolving and complex nature of radiation devices and how they are regulated. The purpose of this review is to explore the issues involved in medical device regulation in radiation oncology. We start with a general review of federal medical device regulation, including explanations of the legal and regulatory framework, and then discuss issues specific to radiation oncology with real-world examples. We also provide our thoughts on potential solutions and reforms to the current system, including better reporting of radiation-related errors in a centralized database, well-defined criteria for establishing substantial equivalence of a new device, and standard postmarket surveillance of radiation devices. Modern radiation therapy is a powerful tool that can help cure many patients' cancers and alleviate others' suffering with limited adverse effects. We must ensure that this promise is never compromised by avoidable mistakes. PMID:22548012
Gaseous diffusion plant transition from DOE to external regulation
Dann, R.K.; Crites, T.R.; Rahm-Crites, L.K.
After many years of operation as government-owned/contractor-operated facilities, large portions of the gaseous diffusion plants (GDPs) at Portsmouth, Ohio, and Paducah, Kentucky, were leased to the United States Enrichment Corporation (USEC). These facilities are now certified by the U.S. Nuclear Regulatory Commission (NRC) and subject to oversight by the Occupational Safety and Health Administration (OSHA). The transition from DOE to NRC regulation was more difficult than expected. The original commitment was to achieve NRC certification in October 1995; however, considerably more time was required and transition-related costs escalated. The Oak Ridge Operations Office originally estimated the cost of transition at $60 million; $240 million has been spent to date. The DOE`s experience in transitioning the GDPs to USEC operation with NRC oversight provides valuable lessons (both positive and negative) that could be applied to future transitions.
Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil.
Yang, Y; Gordon, C J
Propylthiouracil (PTU), an antithyroidal drug that reduces serum L-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), is presumed to lower core temperature (T0) by impairing metabolic thermogenesis. However, it is not understood why PTU-treated animals cannot use behavioral and other thermoeffectors to maintain normal Tc. Male rats were administered PTU in drinking water (0.05 mg/ml) while the following parameters were measured: 1) Tc and motor activity (MA) recorded by radiotelemetry for 24 h at ambient temperatures (Ta) of 10-30 degrees C; 2) selected Ta, MA, and Tc in a temperature gradient; and 3) Tc, MA, and grooming behavior during exposure to heat stress (TH = 34.5 degrees C) for 2 h. PTU reduced serum levels of T4, and T3 by 95 and 60%, respectively. Tc decreased after 3 days of PTU treatment; a 0.5 degree C decrease in Tc persisted throughout the PTU treatment. PTU rats exposed to Ta of 10-30 degrees C maintained a consistent hypothermic Tc during the light phase; however, a deficit in the stability of Tc at night was noted during exposure to 10 degrees C. In the temperature gradient, PTU rats selected warmer Ta, but their Tc was maintained at the same hypothermic levels as observed at fixed Ta values of 15-30 degrees C. Heat stress caused Tc of control rats to increase to 39 degrees C, whereas Tc of the PTU rats was maintained below 38 degrees C. The regulation of Tc at hypothermic levels over a wide range of Ta values and when rats were housed in a temperature gradient indicates that chronic PTU induces a state of regulated hypothermia. PMID:9176328
De Sousa, R C; Harrington, J T; Ricanati, E S; Shelkrot, J W; Schwartz, W B
Previous studies in metabolic alkalosis have demonstrated that two factors are the prime determinants of acid excretion and bicarbonate reabsorption; first, the diversion to distal exchange sites of sodium previously reabsorbed in the proximal tubule and loop of Henle; and, second, a stimulus to sodium-cation exchange greater than that produced by a low-salt diet alone. In the present study we have examined the hypothesis that these two factors are also the prime determinants of acid excretion during the administration of mineral acid loads. To test this hypothesis, we have administered to dogs ingesting a low NaCl diet a daily dose of 7 meq/kg of H+ with anions (chloride, sulfate, or nitrate) whose differing degrees of reabsorbability influence the speed and completeness with which each is delivered to the distal nephron with its accompanying Na+. After 2-3 wk of acid administration, and after an initial urinary loss of Na+ and K+, the steady-state value for plasma [HCO3-] was 8.6 meq/liter below control in the HCl group, 3.7 meq/liter below control in the H2SO4 group, and unchanged from control in the HNO3 group; all of these values were significantly different from each other. We would propose the following explanation for our findings: when HCl is administered chronically, marked acidosis occurs because distal delivery of Cl- is restricted by the ease with which the Cl- can be reabsorbed in the proximal portions of the nephron. Only when Cl- retention produces sufficient hyperchloremia to insure delivery of Na+ (previously reabsorbed in proximal tubule and loop of Henle) to the distal nephron in quantities equal to ingested Cl is this primary constraint removed. In the case of sulfuric and nitric acids, there is no constraint on distal delivery, the nonreabsorbability of the administered anion causing prompt, total delivery of Na+ to exchange sites in quantities equal to administered hydrogen. Thus, with H2SO4 and HNO3 the sole constraint on removal of the acid
Walrand, Stephane; Short, Kevin R; Heemstra, Lydia A; Novak, Colleen M; Levine, James A; Coenen-Schimke, Jill M; Nair, K Sreekumaran
Hyperthyroidism causes increased energy intake and expenditure, although anorexia and higher weight loss have been reported in elderly individuals with hyperthyroidism. To determine the effect of age on energy homeostasis in response to experimental hyperthyroidism, we administered 200 μg tri-iodothyronine (T3) in 7- and 27-mo-old rats for 14 d. T3 increased energy expenditure (EE) in both the young and the old rats, although the old rats lost more weight (147 g) than the young rats (58 g) because of the discordant effect of T3 on food intake, with a 40% increase in the young rats, but a 40% decrease in the old ones. The increased food intake in the young rats corresponded with a T3-mediated increase in the appetite-regulating proteins agouti-related peptide, neuropeptide Y, and uncoupling protein 2 in the hypothalamus, but no increase occurred in the old rats. Evidence of mitochondrial biogenesis in response to T3 was similar in the soleus muscle and heart of the young and old animals, but less consistent in old plantaris muscle and liver. Despite the comparable increase in EE, T3's effect on mitochondrial function was modulated by age in a tissue-specific manner. We conclude that older rats lack compensatory mechanisms to increase caloric intake in response to a T3-induced increase in EE, demonstrating a detrimental effect of age on energy homeostasis. PMID:24344330
Reduced insulin-mediated glucose transport in skeletal muscle is a hallmark of the pathophysiology of T2DM (Type II diabetes mellitus). Impaired intracellular insulin signalling is implicated as a key underlying mechanism. Attention has focused on early signalling events such as defective tyrosine phosphorylation of IRS1 (insulin receptor substrate-1), a major target for the insulin receptor tyrosine kinase. This is required for normal induction of signalling pathways key to many of the metabolic actions of insulin. Conversely, increased serine/threonine phosphorylation of IRS1 following prolonged insulin exposure (or in obesity) reduces signalling capacity, partly by stimulating IRS1 degradation. We now show that IRS1 levels in human muscle are actually increased 3-fold following 1 h of hyperinsulinaemic euglycaemia. Similarly, transient induction of IRS1 (3-fold) in the liver or muscle of rodents occurs following feeding or insulin injection respectively. The induction by insulin is also observed in cell culture systems, although to a lesser degree, and is not due to reduced proteasomal targeting, increased protein synthesis or gene transcription. Elucidation of the mechanism by which insulin promotes IRS1 stability will permit characterization of the importance of this novel signalling event in insulin regulation of liver and muscle function. Impairment of this process would reduce IRS1 signalling capacity, thereby contributing to the development of hyperinsulinaemia/insulin resistance prior to the appearance of T2DM. PMID:16128672