Source: https://patents.justia.com/patent/8673127
Timestamp: 2020-08-11 19:05:29
Document Index: 110141741

Matched Legal Cases: ['§371', 'Application No. 2000', 'Application No. 2000', 'Application No. 01921772', 'Application No. 09176735', 'Application No. 09176735']

US Patent for Biosensor Patent (Patent # 8,673,127 issued March 18, 2014) - Justia Patents Search
Justia Patents Enzyme Included In ApparatusUS Patent for Biosensor Patent (Patent # 8,673,127)
Dec 21, 2010 - Panasonic
This application is a continuation of U.S. patent application Ser. No. 12/456,199, filed Jun. 12, 2009, now abandoned, which is a continuation of U.S. patent application Ser. No. 11/106,078, filed Apr. 14, 2005, now U.S. Pat. No. 7,648,617, which is a continuation of U.S. patent application Ser. No. 09/979,842, filed May 1, 2002, now U.S. Pat. No. 6,911,131, which is a 35 U.S.C. §371 National Stage of PCT International Patent Application No. PCT/JP01/02558, filed Mar. 28, 2001, which claims priority of Japanese Patent Application No. 2000-90362, filed Mar. 29, 2000, and of Japanese Patent Application No. 2000-342537, filed Nov. 9, 2000, the contents of all of which are hereby incorporated by reference into the subject application.
According to Claim 12 of the present invention, in the biosensor as defined in any of Claims 6 to 8, the metallic salt is either or both of magnesium nitrate and calcium nitrate. Claim 12 embodies the metallic, salt in Claim 6 and, therefore, the same effect as in Claim 6 is achieved.
Here, four kinds of two-electrode-system sensors in total are manufactured: three sensors respectively including, as organic acids, malonic acid (HOOC—CH2—COOH) as aliphatic carboxylic acid, glutaric acid (HOOC—CH2—CH2—CH2-COOH), and adipic acid (HOOC—CH2—CH2—CH2—CH2—COOH), and a conventional sensor including no aliphatic carboxylic acid.
40 80 350 600 700
Conventional 3.25% 2.48% 2.05% 2.11% 4.15% sensor
Gly-133 mN 2.15% 1.75% 1.55% 1.28% 1.05% Ser-95 mM 2.54% 2.11% 1.75% 1.45% 1.22% Pro-87 mN 2.38% 1.98% 1.69% 1.40% 1.18% Thr-84 mN 2.18% 2.00% 1.65% 1.39% 1.24% Lys-HCl-55 mM 2.48% 1.89% 1.58% 1.41% 1.14% Sarcosine-122 mM 2.65% 2.08% 1.68% 1.35% 1.25% Taurine-80 mM 2.18% 1.78% 1.43% 1.22% 1.10%
1. A biosensor for measuring the concentration of a specific substance in a sample solution, the biosensor comprising
electrodes comprising at least a working electrode and a counter electrode provided on an insulating support; and
a reagent layer which reacts with the specific substance in the sample solution;
wherein the reagent layer comprises an enzyme, an electron transfer agent, and an organic acid or organic acid salt which has at least one carboxyl group;
the organic acid is aliphatic carboxylic acid, carbocyclic carboxylic acid, heterocyclic carboxylic acid, a substitution product, or derivative of the organic acid;
the carboxylic acid is malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, benzoic acid, phthalic acid, isophthalic acid, terephthalic acid, 2-phthalic acid, nicotinic acid, isonicotinic acid, their salt, or a combination thereof; and
the enzyme is glucose dehydrogenase.
2. The biosensor as defined in claim 1, wherein the reagent layer comprises a hydrophilic polymer.
3. A biosensor for measuring the concentration of a specific substance in a sample solution, the biosensor comprising
wherein the reagent layer includes an enzyme, an electron transfer agent, and an organic acid or organic acid salt which has at least one carboxyl group and one amino group;
the organic acid is an amino acid, a substitution product of an amino acid, sarcosine or betaine;
the amino acid is alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, arginine, lysine, histidine, phenylalanine, tryptophan, proline, their salt, or a combination thereof; and
4. The biosensor as defined in claim 3, wherein the reagent layer comprises a hydrophilic polymer.
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Patent number: 8673127
Patent Publication Number: 20110180404
Inventors: Shoji Miyazaki (Ehime), Hiroyuki Tokunaga (Ehime), Masaki Fujiwara (Ehime), Takahiro Nakaminami (Ehime), Junko Nakayama (Ehime), Eriko Yamanishi (Ehime)
Application Number: 12/928,841
Current U.S. Class: Enzyme Included In Apparatus (204/403.14); Enzyme Included In Apparatus (204/403.04)