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Patent US5498600 - Biologically active mosaic proteins - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsDimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the proteins may have two polypeptide chains, one of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, the second of the chains...http://www.google.com/patents/US5498600?utm_source=gb-gplus-sharePatent US5498600 - Biologically active mosaic proteinsAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS5498600 APublication typeGrantApplication numberUS 08/319,776Publication dateMar 12, 1996Filing dateOct 7, 1994Priority dateOct 12, 1984Fee statusPaidPublication number08319776, 319776, US 5498600 A, US 5498600A, US-A-5498600, US5498600 A, US5498600AInventorsMark J. Murray, James D. KellyOriginal AssigneeZymogenetics, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (21), Non-Patent Citations (176), Referenced by (14), Classifications (19), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetBiologically active mosaic proteins
US 5498600 AAbstract
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4350687 *Feb 10, 1980Sep 21, 1982Research CorporationPlatelet derived cell growth factorUS4443546 *Feb 1, 1982Apr 17, 1984The Beth Israel Hospital AssociationProcess and composition for propagating mammalian cellsUS4479896 *Jul 8, 1983Oct 30, 1984Antoniades Harry NMethod for extraction localization and direct recovery of platelet derived growth factorUS4546082 *Jun 17, 1982Oct 8, 1985Regents Of The Univ. Of CaliforniaE. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteinsUS4568640 *Mar 21, 1983Feb 4, 1986Harvey RubinMethod of inserting amino acid analogs into proteinsUS4588585 *Sep 28, 1984May 13, 1986Cetus CorporationHuman recombinant cysteine depleted interferon-β muteinsUS4590003 *Mar 23, 1984May 20, 1986OncogenPlatelet related growth regulatorUS4599311 *Aug 13, 1982Jul 8, 1986Kawasaki Glenn HGlycolytic promotersfor regulated protein expression: protease inhibitorUS4605413 *Sep 19, 1983Aug 12, 1986The University Of Alabama At BirminghamStimulation of chemotaxis by chemotactic peptidesUS4645828 *Mar 15, 1985Feb 24, 1987OncogenPlatelet related growth regulatorUS4673640 *Apr 30, 1984Jun 16, 1987Biotechnica International, Inc.Regulated protein production using site-specific recombinationUS4849407 *Dec 15, 1986Jul 18, 1989Zymogenetics, Inc.Biologically active mosaic proteinsUS5128321 *Aug 8, 1988Jul 7, 1992Zymogenetics, Inc.PDGF analogs and methods of useEP0103409A2 *Aug 12, 1983Mar 21, 1984Zymogenetics, Inc.Glycolytic promoters for regulated protein expression: protease inhibitorEP0116201A1 *Oct 26, 1983Aug 22, 1984Chiron CorporationSecretory expression in eukaryotesEP0123294A1 *Apr 19, 1984Oct 31, 1984Amgen Inc.Yeast cell transformation vectorsEP0123544A2 *Apr 24, 1984Oct 31, 1984Genentech, Inc.Process for expressing heterologous protein in yeast, expression vehicles and yeast organisms thereforGB2137631A * Title not availableGB2146335A * Title not availableWO1985004413A1 *Mar 27, 1985Oct 10, 1985University Of Medicine And Dentistry Of New JerseyBiodegradable matrix and methods for producing sameWO1986003122A1 *Nov 8, 1985Jun 5, 1986Curatech, Inc.Wound healing agents* Cited by examinerNon-Patent CitationsReference1Alber and Kawasaki, "Nucleotide Sequence of the Triose Phosphate Isomerase Gene of Saccharomyces cerevisiae," J. 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Res. 7:817 820, 1983.71Gazit et al., "Expression of the Normal Human sis/PDGF-2 Coding Sequence Induces Cellular Transformation," Cell 39:89-97, 1984.72 *Gazit et al., Expression of the Normal Human sis/PDGF 2 Coding Sequence Induces Cellular Transformation, Cell 39:89 97, 1984.73Goustin et al., "Expression of c-sis Oncogene and PDGF Receptors in Cell Lines Derived From Hydatidiform Mole: Implications for Autocrine Growth Control," J. Cell Biol. 99(4 part 2):149a, 1984.74 *Goustin et al., Expression of c sis Oncogene and PDGF Receptors in Cell Lines Derived From Hydatidiform Mole: Implications for Autocrine Growth Control, J. Cell Biol. 99(4 part 2):149a, 1984.75Graves et al., "Detection of c-sis Transcripts and Synthesis of PDGF-Like Proteins by Human Osteosarcoma Cells," Science 226:972-974, 1984.76Graves et al., "High Molecular Weight Precursors to Platelet-Derived Growth Factor (PDGF) are Synthesized by Human Osteosarcoma Cells," Fed. Proc. 43:373, 1984.77 *Graves et al., Detection of c sis Transcripts and Synthesis of PDGF Like Proteins by Human Osteosarcoma Cells, Science 226:972 974, 1984.78 *Graves et al., High Molecular Weight Precursors to Platelet Derived Growth Factor (PDGF) are Synthesized by Human Osteosarcoma Cells, Fed. Proc. 43:373, 1984.79Hannink and Donoghue, "Requirement for a Signal Sequence in Biological Expression of the v-sis Oncogene," Science 226:1197-1199, 1984.80 *Hannink and Donoghue, Requirement for a Signal Sequence in Biological Expression of the v sis Oncogene, Science 226:1197 1199, 1984.81Heldin and Westermark, "Platelet-Derived Growth Factor: Mechanism of Action and Relation to Oncogenes," Biol. Cell 50:11A, 1984.82 *Heldin and Westermark, Platelet Derived Growth Factor: Mechanism of Action and Relation to Oncogenes, Biol. 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Abstr. 104:45883x, 1986.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS5605816 *May 30, 1995Feb 25, 1997Chiron CorporationRecombinant DNA encoding PDGF A-chain polypeptidesUS5726290 *May 19, 1995Mar 10, 1998Genentech, Inc.Soluble analogues of integrinsUS6528483Dec 12, 1997Mar 4, 2003André BeaulieuMethod of producing concentrated non-buffered solutions of fibronectinUS6939849May 30, 1995Sep 6, 2005Chiron CorporationRecombinant PDGF A-chain homodimers and methods of useUS7112320Aug 21, 2000Sep 26, 2006Andre BeaulieuSolid wound healing formulations containing fibronectinUS7309604 *Feb 24, 2005Dec 18, 2007Licentia, Ltd.Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteinsUS7566566Aug 28, 2007Jul 28, 2009Vengenics LimitedMaterials and methods involving hybrid vascular endothelial growth factor DNAs and proteinsUS7902149Apr 10, 2009Mar 8, 2011Vegenics Pty LimitedMaterials and methods involving hybrid vascular endothelial growth factor DNAs and proteinsUS8278098Jan 28, 2011Oct 2, 2012Vegenics Pty LimitedMaterials and methods involving hybrid vascular endothelial growth factor DNAs and proteinsUS20040248796 *Feb 4, 2004Dec 9, 2004Kari AlitaloVEGF-B and PDGF modulation of stem cellsUS20050267024 *Feb 24, 2005Dec 1, 2005Ludwig Institute For Cancer ResearchMaterials and methods involving hybrid vascular endothelial growth factor DNAs and proteinsUS20080058263 *Aug 28, 2007Mar 6, 2008Ludwig Institute For Cancer ResearchMaterials and Methods Involving Hybrid Vascular Endothelial Growth Factor DNAs and ProteinsUS20090318352 *Apr 10, 2009Dec 24, 2009Vegenics LimitedMaterials and Methods Involving Hybrid Vascular Endothelial Growth Factor DNAs and ProteinsUS20110207664 *Jan 28, 2011Aug 25, 2011Vegenics Pty LimitedMaterials and Methods Involving Hybrid Vascular Endothelial Growth Factor DNAs and Proteins* Cited by examinerClassifications U.S. Classification514/2.4, 530/399, 514/13.7International ClassificationC07K14/15, A61K38/00, C07K14/49, C12N15/81Cooperative ClassificationC12N2740/11022, A61K38/00, C07K14/005, C07K14/49, C07K2319/02, C07K2319/75, C07K2319/00, C12N15/81, C07K2319/036European ClassificationC07K14/005, C07K14/49, C12N15/81Legal EventsDateCodeEventDescriptionJun 11, 1996CCCertificate of correctionSep 10, 1999FPAYFee paymentYear of fee payment: 4Sep 12, 2003FPAYFee paymentYear of fee payment: 8Sep 17, 2007REMIMaintenance fee reminder mailedOct 5, 2007SULPSurcharge for late paymentYear of fee payment: 11Oct 5, 2007FPAYFee paymentYear of fee payment: 12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services