Source: http://www.google.com/patents/US6182655?dq=5311516
Timestamp: 2016-08-30 04:56:40
Document Index: 206763918

Matched Legal Cases: ['art 100', 'arts 100', 'art 401', 'art 150', 'art 100', 'art 210', 'art 100', 'art 150', 'art 150', 'art 150', 'art 100', 'art 150']

Patent US6182655 - Inhaler for multiple dosed administration of a pharmacological dry powder - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsAn inhaler for multiple dosed administration of a pharmacological dry powder consists externally of a housing (100,150) and of a protective cap (950) which can be removed from a special mouthpiece (900) fitted on the housing. Arranged on the inside there are a slide rail (200), a dosing slide (300),...http://www.google.com/patents/US6182655?utm_source=gb-gplus-sharePatent US6182655 - Inhaler for multiple dosed administration of a pharmacological dry powderAdvanced Patent SearchPublication numberUS6182655 B1Publication typeGrantApplication numberUS 09/077,387PCT numberPCT/CH1996/000430Publication dateFeb 6, 2001Filing dateDec 5, 1996Priority dateDec 7, 1995Fee statusPaidAlso published asCA2239292A1, CA2239292C, CA2392466A1, CA2392466C, DE59605366D1, DE59610935D1, EP0865302A1, EP0865302B1, EP0995457A1, EP0995457B1, USD469527, WO1997020589A1Publication number077387, 09077387, PCT/1996/430, PCT/CH/1996/000430, PCT/CH/1996/00430, PCT/CH/96/000430, PCT/CH/96/00430, PCT/CH1996/000430, PCT/CH1996/00430, PCT/CH1996000430, PCT/CH199600430, PCT/CH96/000430, PCT/CH96/00430, PCT/CH96000430, PCT/CH9600430, US 6182655 B1, US 6182655B1, US-B1-6182655, US6182655 B1, US6182655B1InventorsManfred Keller, Thomas EggimannOriginal AssigneeJago Research AgExport CitationBiBTeX, EndNote, RefManPatent Citations (69), Referenced by (178), Classifications (24), Legal Events (13) External Links: USPTO, USPTO Assignment, EspacenetInhaler for multiple dosed administration of a pharmacological dry powder
The invention relates to a dry powder inhaler with dosed administration of a medical preparation upon inhalation by the patient. The dry powder—in loose form or pre-dosed units for dispensing—is contained in a medicament reservoir. The invention concerns the generic type of inhalers in which, upon activation, a defined dose is first of all introduced from the internal medicament reservoir into the inhalation channel by means of a portioning mechanism, and from there the patient draws this defined dose into his airways via a mouthpiece, in a flow of air generated by aspiration.
Thus, in summary, it may be stated that none of the inhalers known to date can be regarded as optimal. The present invention is therefore based on the problem of producing an inhaler whose functional characteristics are extensively improved. The design construction is intended to conclusively guarantee the prescribed inhalation position and inhalation intensity. In the inhaler there must be a suitable registration and function covering a properly completed inhalation, an omitted inhalation, or an incomplete inhalation; in any event, a multiple dosage is to be prevented. It is necessary to improve the dosing accuracy upon preparation of the individual doses from the medicament reservoir, and the deagglomeration and atomization of the medicament during inhalation. The protection against humidity is to be made more effective and the cleaning of the inhaler should be made easier. It must be ensured that a mouthpiece which has been removed for cleaning is fitted in place again by the patient. The mouthpiece ought to be used as well as in connection with the inhaler to be created as with other inhalers of the present type. Finally, it must be possible for the inhaler to be manufactured efficiently as a mass-produced article and at the same time satisfy all the regulations laid down in drugs legislation.
FIG. 1A inhaler, side view; closed state (starting position→situation A1);
FIG. 18B inhaler, vertical longitudinal section according to FIG. 1D on lin B—B;
The following statement applies to the whole of the description following. If, for the purpose of clarity of the drawing, reference numbers are included in a figure but are not explained in the directly relevant text of the description, then reference is made to their mention in preceding figure descriptions. In the interest of intelligibility, the repeated designation of components in succeeding figures is for the most part omitted if it is clear from the drawings that the components concerned are “recurring” components.
Arranged on the base are two parallel bars 106 which extend from the front side 105 and which each have an outwardly facing indentation 116 in the rear area and an obliquely cut aperture 117 in the front area. Together with two columns 118 lying opposite one another at a distance, and a rail 119 extending along with wall of the lower part 100 of the housing, the indentation 116 delimits a depression-like ball socket 108. There is also an indentation 120 provided in the rail 119, and the indentations 116, 120 of the identical form lie opposite one another. The columns 118 have points 121 which are directed towards one another and which at their deepest point are located in the ball socket 108. On each of the rear columns 118 there is an inwardly pointing hook 122. A raised plug 123 is in each case arranged in front of the front pillars 118, facing towards the front side 105. At the front side 105, two receiving notches 109 are incorporated, as well as two axially extending longitudinal slots 110 in the base—near each housing wall. A safety cam 125 sits to the side at the entrance of each longitudinal slot 110. Between the two bars 106 and the front side 105 there are two U-shaped depressions 124.
When a correct inhalation has been completed and the inhaler has been closed again by swinging the protective cap 950 upwards and pushing it in, the actuation of the counter 700 takes place. Only on pushing the dosing slide 300 back into the starting position—Situation A1—is a cam 703 on the units wheel 701 gripped by the cam 306 situation on the spring leaf 305, and the units wheel 701 thereby turned by one count position.
The slide rail 200, the carriage 500, the dosing slide 300, the shutter 400 lie in the housing parts 100, 150. The valve guide 850 is fitted, and therein the valve shield 800, as well as the complete funnel arrangement—consisting of funnel 690, funnel holder 601 and funnel lid 680—and the counter 700. The valve shield 800 is in its rearmost position, and the dosing slide 300 is located such that the dosing cavity 302, positioned under the funnel outlet 608, can fill with medicament. The closure part 401 of the shutter 400 protrudes into the channel inlet 914. The clamping prongs 163—additionally fixing the mouthpiece 900—sit in its shaft 932 and engage in the grooves 933. The half-cams 912 of the mouthpiece 900, joined together, are locked in the receiving notch 162 in the upper part 150 of the housing. The connector plugs 911 of the mouthpiece 900 pass through the receiving notches 109 in the lower part 100 of the housing, and the ramp 935 of the mouthpiece 900 engages under the front edge of the roof part 210 of the slide rail 200. The side arms 960 of the protective cap 950 protrude through the slots 110 in the lower part 100 of the housing and through the slots 161 in the upper part 150 of the housing and embrace the wings 503, 523 of the carriage 500. The pins 962 now hang in the apertures 505, while the cams 504 engage in the apertures 961. To fix the protective cap 950 in the starting position, the safety cams 125 are locked into the dimples 972.
In situation A7—after completed inhalation—the protective cap 950 is swung fully down, as a result of which the pins 962 have lifted the lamellae 605 of the funnel holder 601 and the wings 405 of the shutter 400 have been unlocked. During a correct inhalation, the valve shield 800 has been sucked forwards. The spring arms 822 with the wedge profiles 823 have surmounted the overspring ribs 157 in the upper part 150 of the housing as a result of the valve shield 800 moving forwards. The shutter 400 was pushed into its front end position by the advancing valve shield 800, by which the means the dosing cavity 302 became free and the medicament was inhaled by the patient.
During the reverse movement of the carriage 500, its spring wedges 514 sit clamped between the catches 321 and the locking teeth 824 and cannot therefore escape. As a result, the dosing slide 300 and the valve shield 800 are now pushed back into the starting position—Situation A1—by the spring wedges 514 and the struts 508, 510. In so doing, the hooks 826, 122 are released from one another.
Instead of the dimples 972 for arresting the protective cap 950 in the pushed-in state—situation A1—an outwardly directed cam could in each case be provided near the entrance to the cap 952 on the upper side of the side arms 960 and engage in slots in the front side 160 of the upper part 150 of the housing in the closed state. In order to detach the protective cap 950 from the mouthpiece 900, the protective cap is to be pressed-in in the area of the lateral grip contours 951, as a result of which the cams come out.
To hold the two halves of the mouthpiece 900 together, complementary connecting elements could be arranged in each case on the inner cut edges of the two halves—for example, a combination of bores and cams—in order for both halves to be joined together again after possible cleaning and drying.
It is also possible to arrange the two complementary grate sections 515, 621 on the one hand on the carriage 500 and on the other hand on the lower part 100 of the housing or on the upper part 150 of the housing. So that vibrations occur only when the protective cap 950 is being pulled out—but not when it is being pushed back—one of the two grate sections 515, 621 can be taken out of operation on each replacement of the protective cap 950, e.g. on a component which is also movable.
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