Source: http://www.google.com/patents/US4537305?dq=U.S.+Patent+
Timestamp: 2016-05-30 15:05:26
Document Index: 697070530

Matched Legal Cases: ['art 5', 'art 5', 'art 5', 'art 5', 'art 5', 'art 5', 'art 5']

Patent US4537305 - Package for storage of medical container - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA package for the storage of a plastic medical container holding a medicinal fluid therein, which package comprises a tray part formed by laminating and molding an outer polyolefin layer, an intermediate layer capable of barriering passage of gases and steam and an inner polyolefin layer in the shape...http://www.google.com/patents/US4537305?utm_source=gb-gplus-sharePatent US4537305 - Package for storage of medical containerAdvanced Patent SearchPublication numberUS4537305 APublication typeGrantApplication numberUS 06/670,660Publication dateAug 27, 1985Filing dateNov 9, 1984Priority dateMay 6, 1982Fee statusPaidAlso published asDE3278358D1, DE8231027U1, EP0093797A1, EP0093797B1Publication number06670660, 670660, US 4537305 A, US 4537305A, US-A-4537305, US4537305 A, US4537305AInventorsNobuyasu TakanashiOriginal AssigneeTerumo Kabushiki KaishaExport CitationBiBTeX, EndNote, RefManPatent Citations (9), Referenced by (50), Classifications (18), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetPackage for storage of medical container
US 4537305 AAbstract
A package for the storage of a plastic medical container holding a medicinal fluid therein, which package comprises a tray part formed by laminating and molding an outer polyolefin layer, an intermediate layer capable of barriering passage of gases and steam and an inner polyolefin layer in the shape of a tray provided round the opening thereof with a flange portion, a lid member formed by laminating an inner polyamide layer, an intermediate layer capable of barriering passage of gases and steam and an outer layer of a resin possessed of thermal resistance enough to withstand the conditions of heat seal, and a hotmelt adhesive layer formed of materials of dissimilar melting points including at least one material identical with said polyolefin in one layer of said tray part and adapted to be inserted between said flange portion of said tray part and the corresponding portion of said lid member to serve as a medium for the flange portion and the lid member to b heat sealed peel openably.
1. A package containing (i) a plastic medical container and (ii) a deoxidizer, said medical container containing a medicinal fluid which will degrade when contacted with oxygen gas and said container being made of a material which is pervious to gases and steam, said package comprising:a tray part having an opening and comprising a laminated structure including an outer polypropylene layer, an intermediate layer capable of barriering passage of gases and steam and and inner polyolefin layer, and a flange portion around said opening; a lid member having a laminated structure including an inner polyamide layer, an intermediate layer capable of barriering passage of gases and steam and an outer layer of a resin having a thermal resistance sufficient to withstand the condition of heat sealing; said intermediate layers being substantially impervious to steam so that the steam which permeates from the medical container is retained within the package whereby the atmosphere in the package may be saturated with said steam; and a hotmelt adhesive layer formed of a blend of polyethylene and polypropylene, said hotmelt adhesive layer being inserted between said flange portion of said tray part and said lid member, said flange portion and said lid member being peel openably heat sealed to each other in a said hotmelt adhesive layer. 2. The package of claim 1, wherein the weight ratio of polyethylene to polypropylene in the hotmelt adhesive layer is in the range of 20:80 to 50:50.
The objects described above are attained by a package for the storage of a plastic medical container holding a medicinal fluid therein, which package comprises a tray part formed by laminating and molding an outer polyolefin layer, an intermediate layer capable of barriering passage of gases and steam, and an inner polyolefin layer in the shape of a tray provided round the opening thereof with a flange portion, a lid member formed by laminating an inner polyamide layer, an intermediate layer capable of barriering passage of gases and steam, and an outer layer of a resin possessed of thermal resistance enough to withstand the conditions of heat seal, and a hotmelt adhesive layer formed of materials of dissimilar melting points including at least one material identical with the polyolefin in one layer of the aforementioned tray part and adapted to be inserted between the aforementioned flange portion of the try part and the corresponding portion of the aforementioned lid member to serve as a medium for the flange portion and the lid member to be heat sealed peel openably.
FIG. 1 is a perspective view illustrating a typical package for the storage of a medical container according to the present invention.
Now, one preferred embodiment of this invention will be described below with reference to the accompanying drawing. The package of the present invention for the storage of a plastic medical container holding a medicinal fluid therein is produced, as illustrated in FIGS. 1-2, by preparing a tray part 5 provided round the opening thereof with a flange portion 4 by molding a laminated sheet comprising a polyolefin layer (outer layer) 1, a layer capable of barriering passage of gases and steam (intermediate layer) 2, and a polyolefin layer (inner layer) 3, separately preparing a lid member 9 formed by laminating a polyamide layer (inner layer) 6, a layer capable of barriering passage of gases and steam (intermediate layer) 7, and a layer possessed of thermal resistance enough to withstand the conditions of heat sealing (outer layer) 8, also preparing a hotmelt adhesive layer 10 comprising a plurality of materials having dissimilar melting points and including at least one material identical with the polyolefin in one of the layers of the tray part 5, and tightly heat sealing the flange portion 4 of the tray part 5 and the corresponding portion of the lid member 9 through the medium of the hotmelt adhesive layer 10 peel openably.
As illustrated in FIGS. 1-2, in a tray part 5 formed of a laminated sheet comprising an outer layer 1 of polypropylene (having a molecular weight of 100,000 to 500,000) 500 μm in thickness, an intermediate layer 2 of ethylene-vinyl alcohol copolymer (having a molecular weight of 10,000 to 50,000) 50 μm in thickness, and an inner layer 3 of polypropylene (having a molecular weight of 100,000 to 500,000) 500 μm in thickness, a pack of deoxidizer held in a bag-like container having one wall thereof made of a gas-pervious sheet of paper was set in the tray part. Further a blood bag 12 made of polyvinyl chloride and containing therein an anticoagulant was set in position in the tray part 5. Then, a lid member 9 obtained by laminating a first layer 6 composed of inner nylon layer 10 μm in thickness and a high barrier layer 10 μm in thickness, an intermediate layer 7 composed of two layers each of a film of biaxially drawn polypropylene (having a molecular weight of 100,000 to 500,000) 20 μm in thickness superposed by a layer of polyvinylidene chloride (having a molecular weight of 10,000 to 15,000) 10 μm in thickness, and an outer layer 8 of polyethylene terephthalate (having a molecular weight of 100,000 to 500,000) was heat sealed by high frequency to the flange portion 4 of the tray part 5 through the medium of a hotmelt adhesive layer 10 of blend composed of polyethylene (having a molecular weight of 50,000 to 100,000) and polypropylene (having a molecular weight of 100,000 to 500,000) in a weight ratio of 70:30 and superposed in advance on the flange portion 1 of the tray part 5. The packages thus produced were tested for concentration of oxygen contained therein by the use of a zirconia type analyzer (made by Toray Ltd). The results were as shown in Table 1. When the procedure described above was repeated by using ethylene-vinyl alcohol copolymer as the material for the layer of the lid member capable of barriering passage of gases and steam, there were obtained similar results.
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