Source: http://www.google.com/patents/US20060184230?ie=ISO-8859-1&dq=6,123,819
Timestamp: 2014-07-10 19:39:18
Document Index: 571701220

Matched Legal Cases: ['art 33', 'art 33', 'art 33', 'art 33', 'art 33', 'art 33', 'art 33']

Patent US20060184230 - Delayed memory device - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsA delivery system for delivering a prosthetic heart valve to a native valve site within the human vasculature. The prosthetic valve is disposed on a balloon at the end of a balloon catheter. The balloon catheter passes through a delivery sleeve assembly and handle. A pull wire travels from the handle...http://www.google.com/patents/US20060184230?utm_source=gb-gplus-sharePatent US20060184230 - Delayed memory deviceAdvanced Patent SearchPublication numberUS20060184230 A1Publication typeApplicationApplication numberUS 11/343,382Publication dateAug 17, 2006Filing dateJan 30, 2006Priority dateJan 11, 2002Also published asCA2507449A1, CA2507449C, CA2688796A1, DE60235834D1, EP1458313A1, EP1458313B1, EP2181668A1, EP2181669A2, EP2181669A3, EP2181670A2, EP2181670A3, US8075616, US20050080483, WO2003055417A1Publication number11343382, 343382, US 2006/0184230 A1, US 2006/184230 A1, US 20060184230 A1, US 20060184230A1, US 2006184230 A1, US 2006184230A1, US-A1-20060184230, US-A1-2006184230, US2006/0184230A1, US2006/184230A1, US20060184230 A1, US20060184230A1, US2006184230 A1, US2006184230A1InventorsJan Solem, Per KimbladOriginal AssigneeSolem Jan O, Kimblad Per OExport CitationBiBTeX, EndNote, RefManReferenced by (7), Classifications (21), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetDelayed memory deviceUS 20060184230 A1Abstract A delivery system for delivering a prosthetic heart valve to a native valve site within the human vasculature. The prosthetic valve is disposed on a balloon at the end of a balloon catheter. The balloon catheter passes through a delivery sleeve assembly and handle. A pull wire travels from the handle to a distal end of the delivery sleeve assembly. Actuation of the handle pulls on the pull wire, which causes openings in a slotted tube of the delivery sleeve assembly to close, thus causing the delivery sleeve assembly to bend. A stretchable cover is placed over the slotted tube for biasing the steerable catheter toward a straight position. Once advanced to the native valve site, the prosthetic valve is deployed by inflating the balloon. Images(12) Claims(20)
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS FIGS. 1 to 4 show the principle of delayed shortening according to the invention. In FIG. 1, a shape-changing member 1, here in the form of a thread 1, made of or at least in part including a shape memory material is shown having a curved shape. This shape is the original shape that the shape-changing member 1 �remembers� and will assume when the temperature thereof passes a certain threshold, e.g. exceeds 30.degree. C. FIG. 2 shows the shape-changing member 1 of FIG. 1 having been straightened by stretching to a substantially straight shape. FIG. 3 illustrates an embodiment of a device according to the invention, where the device is in its non-activated state of shape A. More specifically, by covering the stretched and straight shape-changing member 1 in FIG. 2 with a delay means 2, here in the form of a tube 2 having a sufficiently small inner cross-section, the stretched shape of the shape-changing member 1 can be maintained even when the device is implanted into a human body and the temperature of the shape-changing member 1 thus exceeds the threshold, e.g. 30. degree. C. The delay means 2 may be flexible enough to follow the curves in e.g. vessels, but has a stiffness, here especially in its radial direction, which withstands the shape-changing force of the shape-changing member 1. Thus, having been implanted into the human body, the shape-changing member 1 of the device will strive towards its original, here curved, shape according to FIG. 1, but is restrained by the delay means 2. However, by manufacturing the delay means 2 from a resorbable material, the delay means 2 will be resorbed by time and the shape-changing member 1 will resume its original shape when the delay means 2 has been resorbed to such a degree or extent that it cannot restrain the shape-changing member 1 any longer, as schematically illustrated in FIG. 4. Thus, the device has now �been transformed� from its non-activated long state of shape A (FIG. 3), to an activated, shortened state of shape A′ (FIG. 4), where the device consists essentially of the shape-changing member 1 only. The device in FIG. 3 may be manufactured in the following way. The thread 1 of a shape memory material, e.g. with the shape illustrated in FIG. 2, is programmed to remember the shape illustrated in FIG. 1 by being held in that shape while at the same time being heated to a temperature above said threshold. Upon cooling, beneath the threshold temperature, e.g. down to room temperature, the thread 1 will become more flexible and may more easily be deformed into its previous shape shown in FIG. 2. In this cooled state, the thread 1 is covered by the resorbable tube 2, e.g. by threading the tube 2 onto the thread 1 or by forming the tube 2 around the thread 1. Other embodiments of a device according to the invention may operate and may be manufactured in a corresponding manner. Thus, a shape-changing member of a memory material is first held in a �preferred� state of shape while being heated above a threshold temperature, and then cooled beneath the threshold temperature so that it can easily be deformed into its previous �non-preferred� state of shape. Thereafter, the now �programmed� shape-changing member is �locked� in said non-preferred state of shape by a delay means in such a way that the delay means will obstruct the shape-changing member from resuming its preferred state of shape when being heated again, e.g. in a human body. Referring again to FIG. 3, the inner radius of the tube 2 must not necessarily be so small that the shape-changing member in the form of the thread 1 cannot move at all in the radial direction. Hence, there may be a small radial play in which the shape-changing member 1 can move without consequently being able to change the length of the device to any larger extent. However, the device in FIG. 3 may also be manufactured with essentially no play between the shape-changing member 1 and the inner side of the delay means 2, possibly also with a pretension or bias force from the delay means 2 acting on the shape-changing member 1. In order to clearly illustrate the shortening of the device, the curved thread 1 is located to the left in FIG. 4, but, after its transformation, the thread 1 may just as well be located anywhere along the remaining parts of the tube 2. FIGS. 5 to 8 show the principle of delayed elongation according to the invention. In FIG. 5, a shape-changing member 3, here in the form of a thread 3 of a shape-memory material, is shown having a straight original shape. FIG. 6 shows the shape-changing thread member 3 of FIG. 5 when having been folded to a curved shape. FIG. 7 illustrates an embodiment of a device according to the invention comprising a thread as illustrated in FIG. 6, where the device is in its non-activated state of shape B. By covering the curved shape-changing member 3 with a delay means 4 in the form of a tube 4 of a resorbable material, the curved shape B can be maintained even when the device is implanted into a human body and strives towards its original straight shape. As schematically illustrated in FIG. 8, after implantation into the human body, the delay means 4 is resorbed by time and consequently the shape-changing member 3 will be released to resume its original straight shape B′. Thus, the device has now been transformed from its non-activated short state of shape B (FIG. 7) to an activated, elongated state of shape B′ (FIG. 8). In the illustrated embodiments, the length of the shape-changing member 1;3 is substantially unchanged by the transformation, whereas the shape of the shape-changing member 1;3 is changed so that the length of the device is changed. According to the invention, the material from which the shape-changing member is made may consist of or at least include Nitinol, which is an alloy composed of nickel (54-60%) and titanium. Small traces of chromium, cobalt, magnesium and iron may also be present in Nitinol. Alternatively, other materials such as Shape Memory Polymers (SMP) could be used as the shape memory material. Actually, as far as the present invention concerns, the shape-changing material does not have to be a shape memory material. Any superelastic material would function in most applications. For example stainless steel (and other metals) may also be forced into a non-preferred state of shape by means of a resorbable restraining means. Examples of usable resorbable materials from which the delay means may be made, or that are at least included, are PDS (polydioxanon), Pronova (polyhexaflouropropylen-VDF), Maxon (polyglyconat), Dexon (PGA, polyglycolic acid), Vicryl (polyglactin), PLA (polylactic acid), PDLLA (polydexolactic acid), PLLA (pololevolactic acid), starch, different kinds of sugar, butyric acid, collagen, and collatamp. Depending on the choice of material, the release of the shape-changing forces may be delayed for a desired period of time. Also design parameters such as the thickness of the resorbable material may be set so that the shape-changing forces are delayed as long as desired. The delay time may vary from e.g. a few days up to several years depending on the application. The thickness of the delay means may vary along the device, so that the order in which different parts of the device are released by the delay means may be controlled. FIGS. 9 to 20 show some different embodiments of a device according to the invention. FIG. 9 shows an embodiment of a device according to the invention being an alternative arrangement of a device for delayed elongation as compared to the device shown in FIG. 7. Instead of a resorbable tube 4 as in FIG. 7, the resorbable means comprises resorbable crosslinks 6 which hold the shape-changing member 5 in its curved state of shape and thus the device in its non-activated short state of shape C. Resorbable crosslinks 6 (FIG. 9) may also be combined with a tube 4 (FIG. 7). FIG. 10 shows an embodiment of a device according to the invention in its non-activated elongate state of shape D. Here, the shape-changing member 7 is scissors-shaped. A delay means 8 in the form of a tube 8 of resorbable material holds the shape-changing member 7 in a stretched, elongated state of shape and, thus, also the device in its elongate state of shape D. When the delay means 8 has been sufficiently resorbed, the scissors-shaped shape-changing member 7 will resume its original non-stretched shape and the device is transformed to its activated short state of shape D′ (FIG. 11). FIG. 10 a shows an alternative embodiment of a device according to the invention, where the tube 8 in FIG. 10 is replaced by a delay means in the form of resorbable threads 8 a. The delay means 8 a holds the scissors-shaped shape-changing member 7 a in a stretched, elongate state of shape and, thus, the device in a state of shape corresponding to D in FIG. 10. Referring to FIG. 11 a, when the delay means 8 a is cut off by means of resorption, the shape-changing member 7 a will resume its original non-stretched shape and the device is transformed to its activated short state of shape corresponding to D′ in FIG. 11. FIG. 12 shows an embodiment of a device according to the invention in its non-activated short state of shape E. A scissors-shaped shape-changing member 9 of the device is held in a short state of shape by means of a delay means in the form of a resorbable thread 10, and, thereby, the whole device is held in its short state of shape E. When the delay means 10 is cut off by means of resorption, the shape-changing member 9 will resume its original elongate shape so that the device is transformed to its activated state of shape E′ (FIG. 13). FIG. 14 shows an embodiment of a device according to the invention comprising a shape-changing member in the form of a coil 11 of a shape-memory material having been stretched and arranged in a delay means in the form of a tube 12 of resorbable material. The device is then in its non-activated state of shape F. When the delay means 12 has been sufficiently resorbed, the shape-changing member 11 will resume its original shorter and wider shape as shown in FIG. 16, and the device is transformed to its activated state of shape F′. In an alternative embodiment shown in FIGS. 15 a and 15 b of a device according to the invention, the tube 12 in FIG. 14 is replaced by a resorbable rod 13 provided with grooves 13 a in which a coil 11 is initially wound. The winding of the coil 11 in the grooves 13 a obstructs the coil 11 from resuming its original shape (FIG. 16) and, hence, the device is held in its non-activated state of shape G by the rod 13, as illustrated in FIG. 15 a. By resorption of the rod 13 in e.g. a human body, the shape-changing force of the coil 11 is released and the device is transformed to its activated state of shape G′ as shown in FIG. 16. In another embodiment shown in FIG. 17 of a device according to the invention, a coil 14 is wound around a resorbable rod 15. When the rod 15 is resorbed, the shape-changing forces of the coil 14 will be released so that the coil 14 resumes an original elongate shape, as shown in FIG. 18, whereby the device is transformed from its non-activated state of shape H to its activated state of shape H′. FIG. 19 shows an embodiment of a device according to the invention in the form of a patch for closing or obstructing openings, e.g. in the heart of a human or animal body. The patch has a shape-changing member 16 comprising a grid matrix formed by threads made of memory material such as Nitinol or SMP. The threads may be covered individually by biocompatible material such as PTFE or dacron to fill in the gaps between the threads, e.g. in the way shown in FIG. 26 with threads 28 and biocompatible material 29. The patch in FIG. 19 further comprises a frame 17 for anchoring the patch in the body, e.g. by means of sutures. The frame may be made of any biocompatible material, such as PTFE or dacron. By the use of a cone (not shown), the threads may be spread apart, creating a central opening 16 a in the patch. The cone is advanced until a delay means 18 in the form of a separate ring 18 of a resorbable material, initially positioned on the cone, is positioned in the opening 16 a. The cone is then drawn back and the ring 18 is left in the opening 16 a, restraining the elastic threads in such a way that the central opening 16 a in the patch is maintained. FIG. 19 shows the patch in its non-activated state of shape I with the ring 18 positioned centrally. After implant and sufficient resorption of the restraining ring 18 and after a specified period of time, the central opening in the patch is closed and the patch is activated. FIG. 20 shows an alternative embodiment of a device according to the invention in the form of a patch for closing openings. The patch may be constructed by attaching delay means 19 in the form of resorbable threads or bands 19 to the top of a sharp cone and down along the sides of the cone, advancing the cone through the middle of the patch so that the elastic threads 16 are spread out and thus an opening 16 a in the patch is created, and fastening one end of each band to the frame 17 on one side of the patch and the other end of each band 19 to the frame 17 on the other side of the patch, so that each band 19 encircles the opening. The bands 19 could be placed at regular intervals along the circumference of the opening so that they expand a substantially circular hole in the middle of the patch. By means of the resorbable bands 19, the patch is held in its non-activated state of shape J. It is to be noted that the above-described different embodiments are examples only. There are many possible different forms of a device according to the present invention. For example, the single shape-changing thread in FIGS. 1 to 9 may be replaced by several threads or by one or more bands. The scissors-shaped members 7 and 9 in FIGS. 10 to 13 may be multiplied so as to form a scissor-shaped area, which in turn may be shaped into different forms. The single tube in FIGS. 3, 7, 10 and 14 may be slotted or may be divided into several tube segments. A delay means may also be provided in the form of resorbable glue, which holds parts of the shape-changing member together and in that way delay the change of shape of the device. The number of possible designs of a device according to the invention is, in fact, infinitely great. Next, an embodiment according to the invention of a device for treatment of mitral annulus dilatation will be described. The device shown in FIG. 21, being in an elongate and non-activated state of shape K, comprises a shapechanging member 20 in the form of a shape memory metal thread 20, a delay means 21 in the form of a resorbable sheath 21 enclosing the shape memory metal thread 20 for holding it in a straightened state of shape, and preferably self-expandable stents 22 and 23 located at the opposite ends of the device. The device may include one or more additional shape memory metal threads, e.g. if a stronger shortening force is desired. The shape memory metal thread 20 may be made of Nitinol, or other similar material which has a memory of an original shape as illustrated in FIG. 22, and can be temporarily forced into another shape, e.g. as illustrated in FIG. 21. The resorbable sheath 21 is made of PDS, but it may also be made of any other material which is resorbable by the surrounding blood and tissue when applied in a human body and has the required stability and bending properties. The thickness of the resorbable sheath 21 is chosen so that the time needed for the surrounding blood and tissue in the coronary sinus 24 to resorb the resorbable sheath 21 enough for the device to enter its second shorter state of shape K′ is adapted to the time needed for the ends of the device to be fixed within the coronary sinus 24. The self-expandable stents 22 and 23 may be of conventional type with an elastic cylindrical unit, made of e.g. Nitinol, in an opened zigzag configuration. FIG. 21 a shows an alternative embodiment according to the invention of a device for treatment of mitral annulus dilatation. Here, the shape memory metal thread 20 is replaced by a scissors-shaped shape-changing member 20 a. The resorbable sheath 21 may then be replaced by resorbable threads 21 a, like in FIG. 10 a. Preferably, self-expandable stents 22 a and 23 a are located at the opposite ends of the device. The state of shape corresponding to K′ in FIG. 22 of the device shown in FIG. 21 a is shown in FIG. 22 a. The above-described device as seen in FIG. 21 (or the device as seen in FIG. 21 a), is positioned in the coronary sinus 24, shown in FIGS. 23 to 25, in the following way: An introduction sheath (not shown) of synthetic material may be used to get access to the venous system. Having reached the venous system, a long guiding metal wire (not shown) is advanced through the introduction sheath and via the venous system to the coronary sinus 24. This guiding wire and/or a delivery catheter is provided with X-ray distance markers so that the position of the device in the coronary sinus 24 may be monitored. The elongate device in FIG. 21 (or the one in FIG. 21 a) is locked onto a stent insertion device (not shown) so that the self-expandable stents 22 and 23 (or 22 a and 23 a) are held in a crimped, non-expanded state. Thereafter, the stent insertion device with the elongate device locked thereon is pushed through the introduction sheath and the venous system to the coronary sinus 24 riding on the guiding wire. After having obtained an exact positioning of the elongate device in the coronary sinus 24, as illustrated in FIG. 23 where the mitral valve annulus 25 and the mitral valve 26 having a central gap 27 are shown, the stent insertion device is removed. This will release the self-expandable stents 22 and 23 (or 22 a and 23 a) so that they expand and contact the inner wall of the coronary sinus 24 and thereby provide for a temporary fixation of the elongate device in the coronary sinus 24. Then, the guiding wire and the introduction sheath are removed. After the insertion, the self-expandable stents 22 and 23 (or 22 a and 23 a) will grow into the wall of the coronary sinus 24 while at the same time the resorbable sheath 21 (or restraining threads 21 a) will be resorbed by the surrounding blood and tissue in the coronary sinus 24, as schematically illustrated in FIG. 24. When the resorbable sheath 21 (or resorbable threads 21 a) has been resorbed to such a degree that it cannot hold the shape memory metal thread 20 (or the scissors-shaped member 20 a) in its straightened state of shape any longer, the self-expandable stents 22 and 23 (or 22 a and 23 a) will be properly fixed into the wall of the coronary sinus 24 as a result of the normal healing process which always occurs after positioning a stent in a blood vessel. Then the shape memory metal thread 20 (or the scissors-shaped member 20 a) retracts and the device is transformed to its activated shorter state of shape K′, as illustrated in FIGS. 22 and 25 (corresponding to FIG. 22 a). This shortening of the device makes it bend towards the mitral valve annulus 25, moving the posterior part thereof forward. This movement reduces the circumference of the mitral valve annulus 25 and thereby closes the central gap 27. The device may be positioned by catheter technique or by any other adequate technique. It may be heparin-coated so as to avoid thrombosis in the coronary sinus 24, thus reducing the need for aspirin, ticlopedine or anticoagulant therapy. At least parts of the device may contain or be covered with drugs like Tacrolimus, Rappamycin or Taxiferol to be delivered into the tissue to prohibit excessive reaction from surrounding tissue. At least parts of the device may be covered with or contain VEGF (Vascular Endothelial Growth Factor) to ensure smooth coverage with endothelial cells. FIG. 26 shows one possible arrangement of a part of a contractable area according to the invention. The contractable area comprises a shape-changing member in the form of a grid matrix of shape memory metal threads 28 covered by a delay means in the form of a fabric of a resorbable material (it should be noted that FIG. 26 was previously used to illustrate how the threads of the patches of FIGS. 19 and 20 may be covered with biocompatible material). The fabric comprises resorbable bands 29 which have been weaved together to form an area. Each of the resorbable bands 29 is solid except for a cylindrical hollow space in which a thread 28 is located, just like the thread 1 is located inside the tube 2 in FIG. 3. The bands 29 restrain the threads 28 from being folded to their original curved shapes as long as the fabric 29 is not resorbed. Analogously to the device in FIG. 3, there may be a radial play between the inner wall of each band 29 and the thread 28 being located inside it, in which play the thread 28 can move without consequently being able to change the size of the area of the device to any larger extent. Further, the hollow space in each band 29 must not necessarily be cylindrical. In fact, if the width of each band 29 is small enough as compared to the curves that the threads 28 will assume when being �activated� as a result of the bands 29 being resorbed, the bands 29 may be hollow. The contractable area in FIG. 26 may be manufactured by threading a thread 28 of a memory material into each resorbable band 29 and then weaving the bands 29 with threads 28 together to form the fabric as illustrated in FIG. 26. Another possible way of making a contractable area according to the invention would be to arrange threads or bands of a memory material in a grid matrix and to fix the threads or bands together with resorbable crosslinks. The resorbable crosslinks would then restrain the threads or bands from being folded as long as enough resorbable material in the crosslinks is left unresorbed. A contractable area according to the invention, as the one previously mentioned or as the one shown in FIG. 26, may be formed into a contractable sac as shown in FIGS. 27 to 30, which sac may be used to support a body organ or to restrain a pathologically growing body organ. FIGS. 27 to 30 illustrate the use of a contractable sac 30 for treatment of pathological heart growth, according to another embodiment of the invention. Referring to FIG. 27, the sac 30 in its non-activated state of shape L is threaded inside out on a catheter 31 with an anchoring means 32, here in the form of a suction cup 32, and the catheter 31 with the sac 30 is introduced to the apex cordis 33 a of the heart 33 in known manner. Now referring to FIG. 28, the suction cup 32 is put on the apex cordis 33 a and the sac 30 is pushed off the catheter 31, by means of a catheter instrument (not shown), over the suction cup 32 and up over the heart 33. Now referring to FIG. 29, when the sac 30 is positioned round the heart 33, the suction cup 32 is pulled out through the bottom of the sac 30 and the catheter 31 is removed from the body. After a period of time, the resorbable material of the sac 30 will be resorbed and a restraining force by the shape memory metal threads against the heart 33 is released, and hence, the sac 30 is transformed to its activated state of shape L′, as illustrated in FIG. 30. The sac 30 will then press itself tight round the heart 33 and apply a continuous restraining force on the heart 33, thus decreasing the heart size, or at least preventing the heart 33 from growing further. A contractable area according to the invention can also be used as a contractable sheet for treatment of alveolar sac growth, e.g. in emphysematic pulmonary diseases. FIGS. 31 and 32 show the use of an embodiment of a device according to the invention for treatment of alveolar sac growth. Referring to FIG. 31 a contractable sheet 34 in its non-activated state of shape M is rolled up on a catheter 35, introduced between ribs 36 into the pleural cavity (the space between the pleura of the lung and the pleura of the chest wall), and placed upon the lung 38 surface to be treated. The contractable sheet 34 may also be inserted into the body by means of open surgery or by means of endoscopic surgery and positioned on an organ surface. Now referring to FIG. 32, the sheet 34 is then rolled out over the lung 38 and the catheter 35 is removed. The sheet 34 is arranged to grow fixed to the lung surface so that subsequent contraction of the sheet 34, as a result of the resorbable material of the sheet 34 being resorbed, causes the sheet 34 to compress the lung 38 by means of a force of the shape memory metal threads in the sheet 34. Hence, bullae and areas of enlarged alveolar sacs may be shrunk or eliminated and further pathological growth of alveolar sacs may be prevented. In this embodiment the contractable sheet 34 contracts in two directions, one approximately vertical and one approximately horizontal. The sheet 34 could also be designed to contract in one direction only, e.g. the most horizontal one, or contract in a circular mode, and still be able to shrink bullous areas and prevent alveolar sacs from growing. It is to be understood that modifications of the above described devices and methods can be made by people skilled in the art without departing from the spirit and scope of the invention. Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7500989Jun 3, 2005Mar 10, 2009Edwards Lifesciences Corp.Devices and methods for percutaneous repair of the mitral valve via the coronary sinusUS7637946Feb 1, 2007Dec 29, 2009Edwards Lifesciences CorporationCoiled implant for mitral valve repairUS7717954Aug 20, 2007May 18, 2010Edwards Lifesciences AgDevice and method for treatment of mitral insufficiencyUS8100820Aug 22, 2007Jan 24, 2012Edwards Lifesciences CorporationImplantable device for treatment of ventricular dilationUS8109984Jan 4, 2006Feb 7, 2012Edwards Lifesciences AgMethod and device for treatment of mitral insufficiencyUS8394128 *Apr 27, 2011Mar 12, 2013Simpirica Spine, Inc.Modulated constraining apparatus and methods of useUS20120109199 *Apr 27, 2011May 3, 2012Simpirica Spine, Inc.Modulated constraining apparatus and methods of use* Cited by examinerClassifications U.S. Classification623/1.15International ClassificationA61F2/82, A61F2/848, A61F2/07, A61F2/06, A61F2/04, A61F2/24, A61F2/26, A61F2/02Cooperative ClassificationA61F2/2481, A61F2002/043, A61F2002/826, A61F2002/828, A61F2/26, A61F2/07, A61F2002/072, A61F2002/8483, A61F2210/0004, A61F2/2451European ClassificationA61F2/24W2, A61F2/24R4Legal EventsDateCodeEventDescriptionFeb 10, 2011ASAssignmentOwner name: SYNDEON AB, SWEDENEffective date: 20021129Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SOLEM, JAN OTTO;REEL/FRAME:025788/0526Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:VALVIDA AB;SYNDEON AB;REEL/FRAME:025787/0443Owner name: EDWARDS LIFESCIENCES AG, SWITZERLANDEffective date: 20030214Owner name: VALVIDA AB, SWEDENFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KIMBLAD, PER-OLA;REEL/FRAME:025788/0661RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google