Source: https://patents.google.com/patent/US9919099B2/en
Timestamp: 2019-06-24 19:48:36
Document Index: 552944048

Matched Legal Cases: ['Application No. 07753177', 'Application No. 07753177', 'Application No. 09701298', 'Application No. 10008072', 'Application No. 09743763', 'Application No. 2013', 'Application No. 14152346']

US9919099B2 - Implantable drug pumps and refill devices therefor - Google Patents
US9919099B2
US9919099B2 US13/632,644 US201213632644A US9919099B2 US 9919099 B2 US9919099 B2 US 9919099B2 US 201213632644 A US201213632644 A US 201213632644A US 9919099 B2 US9919099 B2 US 9919099B2
US13/632,644
US20130116664A1 (en
2012-10-01 Priority to US13/632,644 priority patent/US9919099B2/en
2013-01-30 Assigned to MINIPUMPS, LLC reassignment MINIPUMPS, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TAI, YU-CHONG, SHIH, JASON, KAVAZOV, JULIAN D.
2013-05-09 Publication of US20130116664A1 publication Critical patent/US20130116664A1/en
2018-03-20 Publication of US9919099B2 publication Critical patent/US9919099B2/en
In various embodiments, the present invention relates to implantable drug pump devices with fill ports that are plugged with a self-resealable septum, allowing a refill needle to puncture the septum while ensuring that the septum automatically “heals” upon removal of the needle. The septum may be made of a silicone or other biocompatible polymer. To aid resealing, the septum may be shaped such that pressure exerted on the septum by the drug in the reservoir or, on the other side, by the ambient fluid, is directed toward the tunnel, compressing and closing it. For example, the septum may have semispherical protuberances around the needle entry and exit points at the outer and inner septum surfaces. To properly guide the needle, the fill port may include, above the septum, a non-puncturable, flexible layer having a hole aligned with the protuberances.
Accordingly, in one aspect, the invention provides an implantable, refillable drug pump device including a drug reservoir having a fill port defining an aperture through a wall of the reservoir, and a needle-puncturable elastomeric septum extending at least partially through the aperture. In some embodiments, the septum is made of self-healing silicone. The drug pump device may further include a cannula in fluid communication with the drug reservoir for guiding liquid drug from the reservoir to an injection site, and a pump chamber in mechanical communication with the drug reservoir for exerting pressure thereon so as to expel liquid drug from the reservoir into the cannula.
The septum has needle entrance and exit surfaces, one or both of which include a protuberance shaped so as to direct pressure exerted thereon toward a needle puncture path. (A “needle puncture path,” as used herein, denotes a straight line extending from the entrance surface through the septum to the exit surface and defining the path along which the refill needle is preferably inserted into the reservoir. The needle puncture path may (but need not always) be substantially perpendicular to the reservoir wall surrounding the aperture.) In some embodiments, the path extends substantially perpendicularly (e.g., deviating from exact perpendicularity by less than 5°, preferably less than 2°) through the septum, and the protuberances are aligned with the needle puncture path. The protuberance(s) may be substantially semispherical (e.g., such that the distance between surface points and a center of the (semi-)sphere varies by less than 10% around an average distance). The fill port may further include a flexible, non-puncturable layer disposed above the septum and having a hole therethrough that is aligned with the protuberance(s).
In another aspect, the invention provides a drug reservoir and, connected with the drug reservoir via a fluidic channel, a fill port including a deformable septum that compresses in response to pressure exerted by the needle during needle insertion. The septum obstructs a fluid path between the fill port aperture and the fluidic channel when it is in an uncompressed state and opens the fluid path between the fill port aperture and the fluidic channel when it is in a compressed state. In some embodiment, the fill port further includes, above the septum, a second elastomeric septum with a center hole; this second septum serves to seal the port when the needle is inserted. The fill port may further include a needle-impenetrable plate, disposed or attached above the deformable septum, which transfers pressure exerted by the needle onto the septum so as to compress the septum. The port may also have a wall structure that forms a cavity accommodating the second elastomeric septum, the plate, and the deformable septum. In some embodiments, the port also includes a guiding compression disk with a conical aperture for guiding the refill needle into the port.
1. An implantable, refillable drug pump device comprising:
connected with the drug reservoir via a fluidic channel, a fill port for insertion of a refill needle therein, the fill port comprising (i) unitary and deformable septum that compresses, in response to pressure exerted by the needle during needle insertion, from a full thickness to a reduced thickness, (ii) an O-ring above the unitary and deformable septum for sealing the fill port when the needle is inserted, and (iii) a needle-impenetrable plate attached above the unitary and deformable septum, the plate transferring pressure exerted by the needle onto the septum so as to compress the septum,
wherein at the full thickness, the septum obstructs a fluid path between a fill port aperture and the fluidic channel and at the reduced thickness opens the fluid path between the fill port aperture and the fluidic channel.
2. The drug pump device of claim 1, further comprising a wall structure accommodating the O-ring, the needle-impenetrable plate, and the unitary and deformable septum in a cavity formed therein.
3. The drug pump device of claim 1, further comprising a guiding compression disk having a conical aperture for guiding the needle into the port.
4. The drug pump device of claim 1, wherein the deformable septum is convex.
5. The drug pump device of claim 1, wherein the refill needle is non-piercing.
6. The drug pump device of claim 1, wherein the O-ring blocks a leak path of fluid out of the fill port, the O-ring having an uncompressed diameter less than a diameter of the needle.
7. The drug pump device of claim 1, wherein the septum is made of an elastomeric polymer.
US13/632,644 2011-03-14 2012-10-01 Implantable drug pumps and refill devices therefor Active 2033-02-06 US9919099B2 (en)
US13/632,644 US9919099B2 (en) 2011-03-14 2012-10-01 Implantable drug pumps and refill devices therefor
US20130116664A1 US20130116664A1 (en) 2013-05-09
US9919099B2 true US9919099B2 (en) 2018-03-20
ID=48224195
US13/632,644 Active 2033-02-06 US9919099B2 (en) 2011-03-14 2012-10-01 Implantable drug pumps and refill devices therefor
US (1) US9919099B2 (en)
2012-10-01 US US13/632,644 patent/US9919099B2/en active Active
CH570169A5 (en) 1971-12-06 1975-12-15 Mpl Inc Rear filling liq syringe distributor - with filling device
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US20130116664A1 (en) 2013-05-09
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TAI, YU-CHONG;SHIH, JASON;KAVAZOV, JULIAN D.;SIGNING DATES FROM 20121214 TO 20130114;REEL/FRAME:029719/0662