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Timestamp: 2014-03-16 06:03:36
Document Index: 287146693

Matched Legal Cases: ['Application No. 10287662', 'Application No. 10287662', 'Application No. 09914204', 'Application No. 796846', 'Application No. 801060', 'Application No. 2305665', 'Application No. 818448', 'Application No. 818197', 'Application No. 19627430', 'Application No. 09839299']

Use of substituted N, N-disubstituted reverse aminoalcohol compounds for
inhibiting cholesteryl ester transfer protein activity - US Patent 6462092 Description
inhibiting cholesteryl ester transfer protein activity
Patent 6462092 Issued on October 8, 2002.
Estimated Expiration Date: November 14, 2021.
No. 990811 filed on 11/14/2001	US Classes:
514/655, The aryl ring or aryl ring system and amino nitrogen are bonded directly to the same acylic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto
514/649, Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain
514/654, The chain consists of two or more carbons which are unsubtituted or have acyclic hydrocarbyl substituents only
514/658, Two benzene rings bonded directly to the same nitrogen
564/374, The chain consists of two or more carbons which are unsubstituted or have acyclic hydrocarbyl substituents only
564/381, Phenethylamines having alpha alkyl substituent
564/382, Phenethylamines having beta alkyl substituent
564/384, The aryl ring or ring system and amino nitrogen are bonded directly to the same acyclic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto
564/389, Benzyl amines having hydroxy or ether oxygen bonded directly to the benzene ring (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)
564/390, Ortho hydroxy benzyl amines
564/391, Benzyl amines wherein the benzene ring has no other substituents
564/392, Acyclic hydrocarbyl group bonded directly to the methylene carbon
564/447	Of hydroxy containing compound
801060 EP. 10/16/1997
818197 EP. 01/16/1998
2305665 GB. 04/16/1997
09078277 JP. 03/16/1997
10287662 JP. 10/16/1998
98/50029 WO. 11/16/1998
99/14204 WO. 03/16/1999
A61K 031/133 C07C 215/08	DescriptionUnited States Patent: 6462092 ( 1 of 1 )	United States Patent 6,462,092 Sikorski, et al. October 8, 2002 Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity AbstractThe invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted reverse aminoalcohols. A preferred specific N,N-disubstituted reserve aminoalcohol is the compound: ##STR1## Inventors: Sikorski; James A. (Des Peres, MO), Durley; Richard C. (Chesterfield, MO), Mischke; Deborah A. (Defiance, MO), Reinhard; Emily J. (Chesterfield, MO), Fobian; Yvette M. (Labadie, MO), Tollefson; Michael B. (O'Fallon, MO), Wang; Lijuan (Wildwood, MO), Grapperhaus; Margaret L. (Troy, IL), Hickory; Brian S. (Wildwood, MO), Massa; Mark A. (Ballwin, MO), Norton; Monica B. (St. Louis, MO), Vernier; William F. (St. Louis, MO), Parnas; Barry L. (University City, MO), Promo; Michele A. (Chesterfield, MO), Hamme; Ashton T. (St. Louis, MO), Spangler; Dale P. (Deerfield, IL), Rueppel; Melvin L. (St. Louis, MO) Assignee:G.D. Searle & Co. (Chicago, IL)Appl. No.: 09/990,811 Filed: November 14, 2001 Related U.S. Patent Documents Application NumberFiling DatePatent NumberIssue Date<TD 405524Sep., 1999<TD Current U.S. Class: 514/655 ; 514/649; 514/654; 514/658; 564/374; 564/381; 564/382; 564/384; 564/389; 564/390; 564/391; 564/392; 564/447 Current International Class: C07C 217/90 (20060101); C07C 317/36 (20060101); C07C 215/16 (20060101); C07C 229/38 (20060101); C07C 317/32 (20060101); C07C 219/28 (20060101); C07C 311/21 (20060101); C07C 215/08 (20060101); C07C 217/92 (20060101); C07C 219/00 (20060101); C07C 229/60 (20060101); C07C 217/00 (20060101); C07C 217/88 (20060101); C07C 225/22 (20060101); C07C 317/00 (20060101); C07C 235/56 (20060101); C07C 311/00 (20060101); C07C 323/37 (20060101); C07C 215/00 (20060101); C07C 237/38 (20060101); C07C 237/30 (20060101); C07C 235/00 (20060101); C07C 233/25 (20060101); C07C 323/32 (20060101); C07C 233/00 (20060101); C07C 311/58 (20060101); C07C 233/80 (20060101); C07C 323/44 (20060101); C07C 233/43 (20060101); C07C 327/00 (20060101); C07C 271/00 (20060101); C07C 233/69 (20060101); C07C 237/00 (20060101); C07C 275/00 (20060101); C07C 271/28 (20060101); C07C 255/54 (20060101); C07C 323/25 (20060101); C07C 323/19 (20060101); C07C 255/00 (20060101); C07C 323/31 (20060101); C07C 235/20 (20060101); C07C 323/20 (20060101); C07C 323/00 (20060101); C07C 323/65 (20060101); C07C 235/24 (20060101); C07C 327/30 (20060101); C07C 275/34 (20060101); C07D 207/335 (20060101); C07C 255/13 (20060101); C07C 255/58 (20060101); C07C 275/40 (20060101); C07C 255/24 (20060101); C07C 255/21 (20060101); C07D 209/82 (20060101); C07D 209/00 (20060101); C07D 207/00 (20060101); C07D 295/192 (20060101); C07D 239/34 (20060101); C07D 213/00 (20060101); C07D 491/00 (20060101); C07D 491/10 (20060101); B01D 25/127 (20060101); B01D 25/12 (20060101); C07C 229/00 (20060101); C07C 217/84 (20060101); C07C 217/58 (20060101); C07C 219/06 (20060101); C07C 229/52 (20060101); C07C 219/34 (20060101); C07C 225/00 (20060101); C07D 239/26 (20060101); C07D 257/04 (20060101); C07D 307/04 (20060101); C07D 251/00 (20060101); C07D 307/38 (20060101); C07D 213/38 (20060101); C07D 239/00 (20060101); C07D 213/62 (20060101); C07D 307/00 (20060101); C07D 263/00 (20060101); C07D 257/00 (20060101); C07D 251/46 (20060101); C07D 263/04 (20060101); C07D 225/08 (20060101); C07D 333/28 (20060101); C07D 265/14 (20060101); C07D 225/00 (20060101); C07D 295/092 (20060101); C07D 295/135 (20060101); C07D 333/00 (20060101); C07D 333/20 (20060101); C07D 265/00 (20060101); C07D 295/108 (20060101); C07D 295/00 (20060101); A61K 031/133 (); C07C 215/08 () Field of Search: 564/374,381,382,384,389,390,392,442,391 514/649,654,655,658 References Cited [Referenced By]U.S. Patent Documents 2700686January 1955Dickey4333952June 1982McDonald4447608May 1984Jones Foreign Patent Documents 801060Oct., 1997EP818197Jan., 1998EP2305665Apr., 1997GB09078277Mar., 1997JP10287662Oct., 1998JP98/50029Nov., 1998WO99/14204Mar., 1999WO Other References J-P. Begue et al., "A Versatile Synthesis of Amino Trifluoromethyl Ketones and Alcohols", Tetrahedron Letters, vol 33, No. 14, pp. 1879-1882,1992..P. Bravo et al., "New Fluorinated Chiral Synthons", Tetrahedron:Assymmetry, vol. 5, No. 6, pp. 987-1004, 1994..P. Dunn et al., "The Synthesis of Fluorine-containing Pterins", Tetrahedron, vol. 52, No. 40, pp. 13017-13206, 1996..S. Furuta and T. Fuchigami "Electrolytic reactions of fluoroorganic compounds. 16*. Regioselective anodic methoxylation of 2-methoxy-2,3,3,3-tetrafluoropropylamines", Electrochimica Acta, vol. 43, Nos. 21-22, pp. 3183-3191, 1998..L. Lebreton et al., "Structure-Immunosuppressive Activity Relationships of New Analogues of 15-Deoxyspergualin. 2. Structural Modifications of the Spermidine Moiety", J. Med. Chem., vol. 42, pp. 4749-4763, 1999..T. Katagiri et al., "General Syntheses of Optically Active α-Trifluoromethylated Amines via Ring-Opening Reactions of N-Benzyl-2-trifluoromethylaziridine", J. Org. Chem., vol. 64, pp. 7323-7329, 1999..J. M. Concellon et al., "Iodomethylation of Chiral α-Amino Aldehydes by Means of Samarium/Diiodomethane. Application to the Synthesis of Various Enantiomerically Pure Compounds", J. Org. Chem., vol. 62, pp. 8902-8906, 1997..J. Barluenga et al., "Highly Diastereoselective Synthesis of Threo or Erythro Aminoalkyl Expoxides from α-Amino Acids", J. Org. Chem., vol. 60, pp. 6696-6699, 1995..P. L. Beaulieu and D. Wernic, "Preparation of Aminoalkyl Chlorohydrin Hydrochlorides: Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors", J. Org. Chem., vol. 61, No. 11, pp. 3635-3645, 1996..J. M. Concellon et al., "Nucleophilic ring closure and opening of aminoiodohydrins", Tetrahedron Letters, vol. 41, pp. 1231-1234, 2000..P. L. Beaulieu et al., "Large Scale Preparation of (2S,3S)-N-Boc-3-Amino-1,2-Epoxy-4-Phenylbutane: A Key Building Block for HIV-Protease Inhibitors", Tetrahedron Letters, vol. 36, No. 19, pp. 3317-3320, 1995..M.S. 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Harmony, "Cholesteryl Ester Analogs Inhibit Cholesteryl Ester but not Triglyceride Transfer Catalyzed by the Plasma Cholesteryl Ester-Triglyceride Transfer Protein", Lipids, vol. 25, 216-220, 1990..J.C. Lee et al., "A Cholesteryl Ester Transfer Protein Inhibitor from an Insect-associated Fungus", J. Antibiot., vol. 49, 693-696, 1996..R. E. Morton and D. B. Zilversmit, "Purification and Characteriz-ation of Lipid Transfer Protein(s) from Human Lipoprotein-deficient Plasma", J. Lipid Res., vol. 23, 1058-1067, 1982..D.T. Connolly et al., "Inactivation of Cholesteryl Ester Transfer Protein by Cysteine Modification", Biochem. Biophys. Res Commun., vol. 223, 42-47, 1996..C.L. Bisgaier et al., "Cholesteryl Ester Transfer Protein Inhibition by PD 140195", Lipids, vol. 29, 811-818, 1994..Y. Xia et al., "Substituted 1,3,5-Triazines as Cholesteryl Ester Transfer Protein Inhibitors", Biorg. Med. Chem. Lett., vol. 6, 919-922, 1996..S. Kutkevicius and S. Rutkauskas "γ-Chloro-β-Hydroxypropyl Derivatives and their Reaction Products. VI. N-Mono-and N,N-Bis-β, γ-Epoxypropylamines", Lietuvos TSR Aukst. Mokyklu Mokslo Darbai, Chemija ir Chemine Technologija,vol. 8, pp. 99-104 (1967)..S. Kutkevicius and E. A. Samarskis, "γ-Chloro-β-Hydroxypropyl Derivatives of Aromatic Amines and their Reaction Products. XVII. 4-Methyldiphenylamine", Lietuvos TSR Aukst. Mokyklu Mokslo Darbai, Chemija ir Chemine Technologija, vol. 17,pp. 151-154 (1975)..S. Kutkevicius, B. Milukas, and E. A. Samarskis, "Products of Epichlorohydrin Reaction with Aromatic Amines. XVI. 4-Phenyl-1,2,3,4-tetrahydro [f] quinoline", Khim. Geterotsikl. Soedin. (Kaunas. Politekh. Inst., Kaunas, USSR), vol. 9, pp. 1228-1231(1972)..S. Kutkevicius and E. A. Samarskis, "Products of Epichlorohydrin Reaction with Aromatic Amines. XVIII. N-Phenyl-1-Naphthylamine", Khim. Geterotsikl. Soedin. (Kaunas. Politekh. Inst., Kaunas, USSR), vol. 5, pp. 685-688 (1974)..M. Meguro et al., "Ytterbium Triflate and High Pressure-mediated Ring Opening of Epoxides with Amines", J. Chem. Soc., Perkin Trans. 1, vol. 18, pp. 2597-2601 (1994)..Y. Hayashi et al., "A Novel Chiral Super-Lewis Acidic Catalyst for Enantioselective Synthesis", J. Am. Chem. Soc., vol. 118 (23), pp. 5502-5503 (1996).. Primary Examiner: Raymond; Richard L. Attorney, Agent or Firm: Keane; J. TimothyParent Case TextRELATED APPLICATIONSThis is a divisional of pending U.S. patent application Ser. No. 09/405,524, filed Sep. 23, 1999.Claims What we claim is:1. A compound of Formula I: ##STR262##or a pharmaceutically acceptable salt thereof, wherein; n is an integer selected from 0 through 2; R1 is haloalkyl or haloalkoxyalkyl; R2 is hydroxyalkyl or aminoalkyl; Y is a bond or (C(R14)2)q wherein q is 1 or 2; Z is a bond or (C(R15)2)q wherein q is 1 or 2; R14 and R15 are independently hydrido or alkyl; R4, R8, R9, and R13 are independently selected from the group consisting of hydrido, halo, haloalkyl, and alkyl; R5, R6, R7, R10, R11, and R12 are independently selected from the group consisting of hydrido, perhaloaryloxy, alkanoylalkyl, alkanoylalkoxy, alkanoyloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio,hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-alkylcarboxamido, N-haloalkylcarboxamido, N-cycloalkylcarboxamido, N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy,heterocyclylcarbonyl, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aroylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl,cycloalkoxy, cycloalkylalkoxy, hydroxy, amino, thio, nitro, alkylamino, alkylthio, arylamino, aralkylamino, arylthio, arylthioalkyl, alkylsulfonyl, alkylsulfonarnido, monoarylamidosulfonyl, arylsulfonyl, heteroarylthio, heteroarylsulfonyl,heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, halo, haloalkyl,haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aryl, aryloxy, aralkoxy, saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, heteroaralkyl, arylalkenyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido,carboalkoxyalkyl, carboalkoxyalkenyl, carboxamnido, carboxamidoalkyl, and cyano; with the proviso that at least one of R4, R5, R6, R7, and R8 is not hydrido or with the proviso that at least one of R9, R10, R11,R12, and R13 is not hydrido.2. Compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein at least one of R4, R5, R6, R7, and R8 is not hydrido and at least one of R9, R10, R11, R12, and R13 is not hydrido.3. Compound of claim 2 or a pharmaceutically acceptable salt thereof, wherein; n is 0 or 1; R1 is haloalkoxyalkyl or haloalkyl with the proviso that said haloalkyl has two or more halo substituents; R2 is hydroxyalkyl; Y isselected from the group consisting of a bond, CH2, and CH2 CH2 ; Z is selected from the group consisting of a bond, CH2, and CH2 CH2 ; R4, R8, R9, and R13 are independently hydrido or halo; R5,R6, R7, R10, R11, and R12 are independently selected from the group consisting of hydrido, perhaloaryloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy,alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, heteroaralkoxy, heterocyclyloxy, aralkylaryl, aralkyl, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy,alkylamino, alkylthio, arylamino, arylthio, arylsulfonyl, heteroarylthio, heteroarylsulfonyl, aroyl, alkyl, cycloalkyl, cycloalkylalkanoyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl, aryl, aryloxy, aralkoxy, saturated heterocyclyl, heteroaryl,heteroaryloxyalkyl, and heteroaryloxy; with the proviso that at least one of R4, R5, R6, R7, and R8 is not hydrido and with the further proviso that at least one of R9, R10, R11, R12, and R13 is nothydrido.4. Compound of claim 3 or a pharmaceutically acceptable salt thereof, wherein; n is 0 or 1; R1 is selected from the group consisting of trifluoromethyl, 1,1,2,2-tetrafluoroethoxymethyl, trifluoromethoxymethyl, difluoromethyl,chlorodifluoromethyl, and pentafluoroethyl; R2 is hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and 1,2-dihydroxyethyl; Y is CH2 or CH2 CH2 ; Z is a bond; R4, R8, R9, and R13 are independently hydrido orfluoro; R5 and R10 are independently selected from the group consisting of 4-aminophenoxy, benzoyl, benzyl, benzyloxy, 5-bromo-2-fluorophenoxy, 4-bromo-3-fluorophenoxy, 4-bromo-2-nitrophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy,4-bromophenoxy, 5-bromopyrid-2-yloxy, 4-butoxyphenoxy, chloro, 3-chlorobenzyl, 2-chlorophenoxy, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 3-chloro-4-fluorobenzyl, 3-chloro-4-fluorophenyl, 3-chloro-2-fluorobenzyloxy, 3-chlorobenzyloxy, 4-chlorobenzyloxy,4-chloro-3-methylphenoxy, 2-chloro-4-fluorophenoxy, 4-chloro-2-fluorophenoxy, 4-chlorophenoxy, 3-chloro-4-ethylphenoxy, 3-chloro-4-methylphenoxy, 3-chloro-4-fluorophenoxy, 4-chloro-3-fluorophenoxy, 4-chlorophenylamino, 5-chloropyrid-3-yloxy,2-cyanopyrid-3-yloxy, 4-cyanophenoxy, cyclobutoxy, cyclobutyl, cyclohexoxy, cyclohexylmethoxy, cyclopentoxy, cyclopentyl, cyclopentylcarbonyl, cyclopropyl, cyclopropylmethoxy, cyclopropoxy, 2,3-dichlorophenoxy, 2,4-dichlorophenoxy, 2,4-dichlorophenyl,3,5-dichlorophenyl, 3,5-dichlorobenzyl, 3,4-dichlorophenoxy, 3,4-difluorophenoxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,3-difluorobenzyloxy, difluoromethoxy, 3,5-difluorophenoxy, 3,4-difluorophenyl, 3,5-difluorobenzyloxy,4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethoxyphenoxy, 3-dimethylaminophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyl, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy,2,2-dimethylpropoxy, 1,3-dioxan-2-yl, 1,4-dioxan-2-yl, 1,3-dioxolan-2-yl, ethoxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, fluoro, 4-fluoro-3-methylbenzyl, 4-fluoro-3-methylphenyl,4-fluoro-3-methylbenzoyl, 4-fluorobenzyloxy, 2-fluoro-3-methylphenoxy, 3-fluoro-4-methylphenoxy, 3-fluorophenoxy, 3-fluoro-2-nitrophenoxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy,4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-fluoropyrid-2-yloxy, 2-furyl, 3-furyl, heptafluoropropyl,1,1,1,3,3,3-hexafluoropropyl, 2-hydroxy-3,3,3-trifluoropropoxy, 3-iodobenzyloxy, isobutyl, isobutylamino, isobutoxy, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, isopropoxy, isopropyl, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy,isopropylthio, 4-isopropyl-3-methylphenoxy, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-methoxybenzyl, 4-methoxycarbonylbutoxy, 3-methoxycarbonylprop-2-enyloxy, 4-methoxyphenyl, 3-methoxyphenylamino, 4-methoxyphenylamino, 3-methylbenzyloxy,4-methylbenzyloxy, 3-methylphenoxy, 3-methyl-4-methylthiophenoxy, 4-methylphenoxy, 1-methylpropoxy, 2-methylpyrid-5-yloxy, 4-methylthiophenoxy, 2-naphthyloxy, 2-nitrophenoxy, 4-nitrophenoxy, 3-nitrophenyl, 4-nitrophenylthio, 2-oxazolyl, 4-oxazolyl,5-oxazolyl, pentafluoroethyl, pentafluoroethylthio, 2,2,3,3,3-pentafluoropropyl, 1,1,3,3,3-pentafluoropropyl, 1,1,2,2,3-pentafluoropropyl, phenoxy, phenylamino, 1-phenylethoxy, phenylsulfonyl, 4-propanoylphenoxy, propoxy, 4-propylphenoxy,4-propoxyphenoxy, thiophen-3-yl, sec-butyl, 4-sec-butylphenoxy, tert-butoxy, 3-tert-butylphenoxy, 4-tert-butylphenoxy, 1,1,2,2-tetrafluoroethoxy, tetrahydrofuran-2-yl, 2-(5,6,7,8-tetrahydronaphthyloxy), thiazol-2-yl, thiazol-4-yl, thiazol-5-yl,thiophen-2-yl, 2,3,5-trifluorobenzyloxy, 2,2,2-trifluoroethoxy, 2,2,2-trifluoroethyl, 3,3,3-trifluoro-2-hydroxypropyl, trifluoromethoxy, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy,trifluoromethyl, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 1,1-bis-trifluoromethyl-1-hydroxymethyl, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy,3-trifluoromethylphenoxy, 3-trifluoromethylphenyl, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,4-trifluorophenyl, 2,3,5-trifluorophenoxy, 3,4,5-trimethylphenoxy, 3-difluoromethoxyphenoxy,3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, 3-trifluoromethylthiophenoxy, 3-trifluoromethylthiobenzyloxy, and trifluoromethylthio; R6 and R11 are independently selected from the group consisting of chloro, fluoro, hydrido,pentafluoroethyl, 1,1,2,2-tetrafluoroethoxy, trifluoromethyl, and trifluoromethoxy; R7 and R12 are independently selected from the group consisting of hydrido, fluoro, and trifluoromethyl.5. Compound of claim 4 or a pharmaceutically acceptable salt thereof, wherein; n is 0; R1 is selected from the group consisting of trifluoromethyl, difluoromethyl, chlorodifluoromethyl, and pentafluoroethyl; R2 is hydroxymethyl or1-hydroxyethyl; Y is CH2 ; Z is a bond; R4, R8, R9, and R13 are independently hydrido or fluoro; R5 and R10 are independently selected from the group consisting of benzyloxy, 5-bromo-2-fluorophenoxy,4-bromo-3-fluorophenoxy, 3-bromobenzyloxy, 4-bromophenoxy, 4-butoxyphenoxy, 3-chlorobenzyloxy, 2-chlorophenoxy, 4-chloro-3-ethylphenoxy, 4-chloro-3-methylphenoxy, 2-chloro-4-fluorophenoxy, 4-chloro-2-fluorophenoxy, 4-chlorophenoxy,3-chloro-4-ethylphenoxy, 3-chloro-4-methylphenoxy, 3-chloro-4-fluorophenoxy, 4-chloro-3-fluorophenoxy, 4-chlorophenylamino, 5-chloropyrid-3-yloxy, cyclobutoxy, cyclobutyl, cyclohexylmethoxy, cyclopentoxy, cyclopentyl, cyclopentylcarbonyl,cyclopropylmethoxy, 2,3-dichlorophenoxy, 2,4-dichlorophenoxy, 2,4-dichlorophenyl, 3,5-dichlorophenyl, 3,5-dichlorobenzyl, 3,4-dichlorophenoxy, 3,4-difluorophenoxy, 2,3-difluorobenzyloxy, 3,5-difluorobenzyloxy, difluoromethoxy, 3,5-difluorophenoxy,3,4-difluorophenyl, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethoxyphenoxy, 3-dimethylaminophenoxy, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 1,3-dioxolan-2-yl, 4-ethylbenzyloxy,3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, 4-fluoro-3-methylbenzyl, 4-fluorobenzyloxy, 2-fluoro-3-methylphenoxy, 3-fluoro-4-methylphenoxy, 3-fluorophenoxy, 3-fluoro-2-nitrophenoxy, 2-fluoro-3-trifluoromethylbenzyloxy,3-fluoro-5-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 2-furyl, 3-furyl, heptafluoropropyl, 1,1,1,3,3,3-hexafluoropropyl,2-hydroxy-3,3,3-trifluoropropoxy, isobutoxy, isobutyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, isopropoxy, 4-isopropylbenzyloxy, 3-isopropylphenoxy, isopropylthio, 4-isopropyl-3-methylphenoxy, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl,3-methoxybenzyl, 4-methoxyphenylamino, 3-methylbenzyloxy, 4-methylbenxyloxy, 3-methylphenoxy, 3-methyl-4-methylthiophenoxy, 4-methylphenoxy, 1-methylpropoxy, 2-methylpyrid-5-yloxy, 4-methylthiophenoxy, 2-naphthyloxy, 2-nitrophenoxy, 4-nitrophenoxy,3-nitrophenyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, pentafluoroethyl, pentafluoroethylthio, 2,2,3,3,3-pentafluoropropyl, 1,1,3,3,3-pentafluoropropyl, 1,1,2,2,3-pentafluoropropyl, phenoxy, phenylaamino, 1-phenylethoxy, 4-propylphenoxy, 4-propoxyphenoxy,thiophen-3-yl, tert-butoxy, 3-tert-butylphenoxy, 4-tert-butylphenoxy, 1,1,2,2-tetrafluoroethoxy, tetrahydrofuran-2-yl, 2-(5,6,7,8-tetrahydronaphthytoxy), thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, thiophen-2-yl, 2,2,2-trifluoroethoxy,2,2,2-trifluoroethyl, 3,3,3-trifluoro-2-hydroxypropyl, trifluoromethoxy, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 4-trifluoromethoxyphenoxy, 3-trifluoromethoxyphenoxy, trifluoromethyl, 3-trifluoromethylbenzyloxy,1,1-bis-trifluoromethyl-1-hydroxymethyl, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy, 3-trifluoromethylphenoxy, 3-trifluoromethylphenyl, 2,3,4-trifluorophenoxy, 2,3,5-trifluorophenoxy, 3,4,5-trimethylphenoxy,3-difluoromethoxyphenoxy, 3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, 3-trifluoromethylthiophenoxy, 3-trifluoromethylthiobenzyloxy, and trifluoromethylthio; R6 and R11 are independently selected from the group consistingof chloro, fluoro, hydrido, pentafluoroethyl, 1,1,2,2-tetrafluoroethoxy, and trifluoromethyl; R7 and R12 are independently selected from the group consisting of hydrido, fluoro, and trifluoromethyl.6. Compound of claim 3 of Formula II: ##STR263##or a pharmaceutically acceptable salt thereof, wherein; R1 is haloalkyl; R4, R8, R9, and R13 are independently hydrido or halo; R5, R6, R7, R10, R11, and R12 are independently selectedfrom the group consisting of hydrido, perhaloaryloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, aralkanoylalkoxy, aralkenoyl, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, heteroaralkoxy, aralkyl, haloalkylthio,alkoxy, cycloalkoxy, cycloalkylalkoxy, alkylthio, arylamino, arylthio, arylsulfonyl, aroyl, alkyl, cycloalkyl, cycloalkylalkanoyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl, aryl, aryloxy, aralkoxy, heteroaryl, heteroaryloxyalkyl , and heteroaryloxy; with the proviso that at least one of R4, R5, R6, R7, and R8 is not hydrido and with the further proviso that at least one of R9, R10, R11, R12, and R13 is not hydrido.7. Compound of claim 6 or a pharmaceutically acceptable salt thereof, wherein; R1 is trifluoromethyl; R4, R8, R9, and R13 are independently hydrido or fluoro; R5 is selected from the group consisting of5-bromo-2-fluorophenoxy, 4-chloro-3-ethylphenoxy, 2,3-dichlorophenoxy, 3,4-dichlorophenoxy, 3-difluoromethoxyphenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3-ethylphenoxy, 3-ethyl-5-methylphenoxy, 4-fluoro-3-methylphenoxy, 4-fluorophenoxy,3-isopropylphenoxy, 3-methylphenoxy, 3-pentafluoroethylphenoxy, 3-tert-butylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, 2-(5,6,7,8-tetrahydronaphthyloxy), 3-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, and3-trifluoromethylthiophenoxy; R10 is selected from the group consisting of cyclopentyl, 1,1,2,2-tetrafluoroethoxy, 2-furyl, 1,1-bis-trifluoromethyl-1-hydroxymethyl, pentafluoroethyl, trifluoromethoxy, trifluoromethyl, and trifluoromethylthio; R6, R7, R11, and R12 are independently hydrido or fluoro.8. Compound of claim 7 or a pharmaceutically acceptable salt thereof, wherein; R1 is trifluoromethyl; R4, R8, R9, and R13 are independently hydrido or fluoro; R5 is selected from the group consisting of5-bromo-2-fluorophenoxy, 4-chloro-3-ethylphenoxy, 2,3-dichlorophenoxy, 3,4-dichlorophenoxy, 3-difluoromethoxyphenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3-ethylphenoxy, 3-ethyl-5-methylphenoxy, 4-fluoro-3-methylphenoxy, 4-fluorophenoxy,3-isopropylphenoxy, 3-methylphenoxy, 3-pentafluoroethylphenoxy, 3-tert-butylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, 2-(5,6,7,8-tetrahydronaphthyloxy), 3-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 3-trifluoromethylbenzyloxy, and3-trifluoromethylthiophenoxy; R10 is selected from the group consisting of 1,1,2,2-tetrafluoroethoxy, pentafluoroethyl, and trifluoromethyl; R6, R7, R11, and R12 are independently hydrido or fluoro.9. Compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is a compound of Formula III: ##STR264##wherein R4, R5, R6, R7, R10, and n are selected to form a compound selected from the group consisting of; n is 0, R4 is H, R5 is 4-chloro-3-ethylphenoxy, R6 is H, R7 is H, and R10 is1,1,2,2-tetrafluoroethoxy; n is 2, R4 is hydrido, R5 is phenoxy, R6 is hydrido, R7 is hydrido, and R10 is 1,1,2,2-tetrafluoroethoxy; n is 2, R4 is hydrido, R5 is trifluoromethoxy, R6 is hydrido, R7 ishydrido, and R10 is 1,1,2,2-tetrafluoroethoxy; n is 2, R4 is fluoro, R5 is hydrido, R6 is hydrido, R7 is fluoro, and R10 is 1,1,2,2-tetrafluoroethoxy; n is 2, R4 is hydrido, R5 is fluoro, R6 is hydrido,R7 is hydrido, and R10 is 1,1,2,2-tetrafluoroethoxy; n is 2, R4 is hydrido, R5 is phenoxy, R6 is hydrido, R7 is hydrido, and R10 is trifluoromethoxy; n is 2, R4 is hydrido, R5 is trifluoromethoxy, R6 ishydrido, R7 is hydrido, and R10 is trifluoromethoxy; n is 2, R4 is hydrido, R5 is hydrido, R6 is phenyl, R7 is hydrido, and R10 is trifluoromethoxy; and n is 2, R4 is hydrido, R5 is phenyl, R6 ishydrido, R7 is hydrido, and R10 is trifluoromethoxy.10. A pharmaceutical composition comprising a therapeutically effecfive amount of a compound or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, said compound being of Formula I: ##STR265##wherein; n is an integer selected from 0 through 2; R1 is haloalkyl or haloalkoxyalkyl; R2 is hydroxyalkyl or aminoalkyl; Y is a bond or (C(R14)2)q wherein q is 1 or 2; Z is a bond or (C(R15)2)qwherein q is 1 or 2; R14 and R15 are independently hydrido or alkyl; R4, R8, R9, and R13 are independently selected from the group consisting of hydrido, halo, haloalkyl, and alkyl; R5, R6, R7, R10,R11, and R12 are independently selected from the group consisting of hydrido, perhaloaryloxy, alkanoylalkyl, alkanoylalkoxy, alkanoyloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy,alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-alkylcarboxamido, N-haloalkylcarboxamido, N-cycloalkylcarboxamido, N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, carboxy, heteroaralkylthio,heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aroylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl, aralkenyl, aralkynyl, heterocyclyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, cycloalkoxy, cycloalkylalkoxy, hydroxy, amino, thio, nitro,alkylamino, alkylthio, arylamino, aralkylamino, arylthio, arylthioalkyl, alkylsulfonyl, alkylsulfonamido, monoarylamidosulfonyl, arylsulfonyl, heteroarylthio, heteroarylsulfonyl, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl,heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aryl, aryloxy, aralkoxy,saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, heteroaralkyl, arylalkenyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboxamido, carboxamidoalkyl, andcyano; with the proviso that at least one of R4, R5, R6, R7, and R8 is not hydrido or with the proviso that at least one of R9, R10, R11, R12, and R13 is not hydrido.11. The pharmaceutical composition of claim 10, wherein said compound is of Formula I, wherein at least one of R4, R5, R6, R7, and R8 is not hydrido and at least one of R9, R10, R11, R12, and R13is not hydrido.12. The pharmaceutical composition of claim 11, wherein said compound is of Formula I, wherein; n is 0 or 1; R1 is haloalkyl or haloalkoxyalkyl; R2 is hydroxyalkyl; Y is selected from the group consisting of a bond, CH2, andCH2 CH2 ; Z is selected from the group consisting of a bond, CH2, and CH2 CH2 ; R4, R8, R9, and R13 are independently hydrido or halo; R5, R6, R7, R10, R11, and R12 areindependently selected from the group consisting of hydrido, perhaloaryloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl,N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, heteroaralkoxy, heterocyclyloxy, aralkylaryl, aralkyl, haloalkylthio, alkoxy, cycloalkoxy, cycloalkylalkoxy, alkylamino, alkylthio, arylamino, arylthio, arylsulfonyl,heteroarylthio, heteroarylsulfonyl, aroyl, alkyl, cycloalkyl, cycloalkylalkanoyl, halo, haloalkyl, haloalkoxy, hydroxyhaloalkyl, aryl, aryloxy, aralkoxy, saturated heterocyclyl, heteroaryl, heteroaryloxyalkyl, and heteroaryloxy; with the proviso that atleast one of R4, R5, R6, R7, and R8 is not hydrido and with the further proviso that at least one of R9, R10, R11, R12, and R13 is not hydrido.13. The pharmaceutical composition of claim 12, wherein said compound is of Formula I, wherein; n is 0 or 1; R1 is selected from the group consisting of trifluoromethyl, 1,1,2,2-tetrafluoroethoxymethyl, trifluoromethoxymethyl,difluoromethyl, chlorodifluoromethyl, and pentafluoroethyl; R2 is hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, and 1,2-dihydroxyethyl; Y is CH2 or CH2 CH2 ; Z is a bond; R4, R8, R9, and R13 are independentlyhydrido or fluoro; R5 and R10 are independently selected from the group consisting of 4-aminophenoxy, benzoyl, benzyl, benzyloxy, 5-bromo-2-fluorophenoxy, 4-bromo-3-fluorophenoxy, 4-bromo-2-nitrophenoxy, 3-bromobenzyloxy, 4-bromobenzyloxy,4-bromophenoxy, 5-bromopyrid-2-yloxy, 4-butoxyphenoxy, chloro, 3-chlorobenzyl, 2-chlorophenoxy, 4-chlorophenoxy, 4-chloro-3-ethylphenoxy, 3-chloro-4-fluorobenzyl, 3-chloro-4-fluorophenyl, 3-chloro-2-fluorobenzyloxy, 3-chlorobenzyloxy, 4-chlorobenzyloxy,4-chloro-3-methylphenoxy, 2-chloro-4-fluorophenoxy, 4-chloro-2-fluorophenoxy, 4-chlorophenoxy, 3-chloro-4-ethylphenoxy, 3-chloro-4-methylphenoxy, 3-chloro-4-fluorophenoxy, 4-chloro-3-fluorophenoxy, 4-chlorophenylamino, 5-chloropyrid-3-yloxy,2-cyanopyrid-3-yloxy, 4-cyanophenoxy, cyclobutoxy, cyclobutyl, cyclohexoxy, cyclohexylmethoxy, cyclopentoxy, cyclopentyl, cyclopentylcarbonyl, cyclopropyl, cyclopropylmethoxy, cyclopropoxy, 2,3-dichlorophenoxy, 2,4-dichlorophenoxy, 2,4-dichlorophenyl,3,5-dichlorophenyl, 3,5-dichlorobenzyl, 3,4-dichlorophenoxy, 3,4-difluorophenoxy, 2,3-difluorobenzyloxy, 2,4-difluorobenzyloxy, 3,4-difluorobenzyloxy, 2,5-difluorobenzyloxy, difluoromethoxy, 3,5-difluorophenoxy, 3,4-difluorophenyl, 3,5-difluorobenzyloxy,4-difluoromethoxybenzyloxy, 2,3-difluorophenoxy, 2,4-difluorophenoxy, 2,5-difluorophenoxy, 3,5-dimethoxyphenoxy, 3-dimethylaminophenoxy, 3,5-dimethylphenoxy, 3,4-dimethylphenoxy, 3,4-dimethylbenzyl, 3,4-dimethylbenzyloxy, 3,5-dimethylbenzyloxy,2,2-dimethylpropoxy, 1,3-dioxan-2-yl, 1,4-dioxan-2-yl, 1,3-dioxolan-2-yl, ethoxy, 4-ethoxyphenoxy, 4-ethylbenzyloxy, 3-ethylphenoxy, 4-ethylaminophenoxy, 3-ethyl-5-methylphenoxy, fluoro, 4-fluoro-3-methylbenzyl, 4-fluoro-3-methylphenyl,4-fluoro-3-methylbenzoyl, 4-fluorobenzyloxy, 2-fluoro-3-methylphenoxy, 3-fluoro-4-methylphenoxy, 3-fluorophenoxy, 3-fluoro-2-nitrophenoxy, 2-fluoro-3-trifluoromethylbenzyloxy, 3-fluoro-5-trifluoromethylbenzyloxy, 4-fluoro-2-trifluoromethylbenzyloxy,4-fluoro-3-trifluoromethylbenzyloxy, 2-fluorophenoxy, 4-fluorophenoxy, 2-fluoro-3-trifluoromethylphenoxy, 2-fluorobenzyloxy, 4-fluorophenylamino, 2-fluoro-4-trifluoromethylphenoxy, 4-fluoropyrid-2-yloxy, 2-furyl, 3-furyl, heptafluoropropyl,1,1,1,3,3,3-hexafluoropropyl, 2-hydroxy-3,3,3-trifluoropropoxy, 3-iodobenzyloxy, isobutyl, isobutylamino, isobutoxy, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, isopropoxy, isopropyl, 4-isopropylbenzyloxy, 3-isopropylphenoxy, 4-isopropylphenoxy,isopropylthio, 4-isopropyl-3-methylphenoxy, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-methoxybenzyl, 4-methoxycarbonylbutoxy, 3-methoxycarbonylprop-2-enyloxy, 4-methoxyphenyl, 3-methoxyphenylamino, 4-methoxyphenylamino, 3-methylbenzyloxy,4-methylbenzyloxy, 3-methylphenoxy, 3-methyl-4-methylthiophenoxy, 4-methylphenoxy, 1-methylpropoxy, 2-methylpyrid-5-yloxy, 4-methylthiophenoxy, 2-naphthyloxy, 2-nitrophenoxy, 4-nitrophenoxy, 3-nitrophenyl, 4-nitrophenylthio, 2-oxazolyl, 4-oxazolyl,5-oxazolyl, pentafluoroethyl, pentafluoroethylthio, 2,2,3,3,3-pentafluoropropyl, 1,1,3,3,3-pentafluoropropyl, 1,1,2,2,3-pentafluoropropyl, phenoxy, phenylamino, 1-phenylethoxy, phenylsulfonyl, 4-propanoylphenoxy, propoxy, 4-propylphenoxy,4-propoxyphenoxy, thiophen-3-yl, sec-butyl, 4-sec-butylphenoxy, tert-butoxy, 3-tert-butylphenoxy, 4-tert-butylphenoxy, 1,1,2,2-tetrafluoroethoxy, tetrahydrofuran-2-yl, 2-(5,6,7,8-tetrahydronaphthyloxy), thiazol-2-yl, thiazolyl, thiazol-5-yl,thiophen-2-yl, 2,3,5-trifluorobenzyloxy, 2,2,2-trifluoroethoxy, 2,2,2-trifluoroethyl, 3,3,3-trifluoro-2-hydroxypropyl, trifluoromethoxy, 3-trifluoromethoxybenzyloxy, 4-trifluoromethoxybenzyloxy, 3-trifluoromethoxyphenoxy, 4-trifluoromethoxyphenoxy,trifluoromethyl, 3-trifluoromethylbenzyloxy, 4-trifluoromethylbenzyloxy, 2,4-bis-trifluoromethylbenzyloxy, 1,1-bis-trifluoromethyl-1-hydroxymethyl, 3-trifluoromethylbenzyl, 3,5-bis-trifluoromethylbenzyloxy, 4-trifluoromethylphenoxy,3-trifluoromethylphenoxy, 3-trifluoromethylphenyl, 3-trifluoromethylthiobenzyloxy, 4-trifluoromethylthiobenzyloxy, 2,3,4-trifluorophenoxy, 2,3,4-trifluorophenyl, 2,3,5-trifluorophenoxy, 3,4,5-trimethylphenoxy, 3-difluoromethoxyphenoxy,3-pentafluoroethylphenoxy, 3-(1,1,2,2-tetrafluoroethoxy)phenoxy, 3-trifluoromethylthiophenoxy, 3-trifluoromethylthiobenzyloxy, and trifluoromethylthio; R6 and R11 are independently selected from the group consisting of chloro, fluoro, hydrido,pentafluoroethyl, 1,1,2,2-tetrafluoroethoxy, trifluoromethyl, and trifluoromethoxy; R7 and R12 are independently selected from the group consisting of hydrido, fluoro, and trifluoromethyl. Description FIELD OF THE INVENTIONThis invention is in the field of treating cardiovascular disease, and specifically relates to compounds, compositions and methods for treating atherosclerosis and other coronary artery disease. More. particularly, the invention relates tosubstituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds that inhibit cholesteryl ester transfer protein (CETP), also known as plasma lipid transfer protein-I.BACKGROUND OF THE INVENTIONNumerous studies have demonstrated that a low plasma concentration of high density lipoprotein (HDL) cholesterol is a powerful risk factor for the development of atherosclerosis (Barter and Rye, Atherosclerosis, 121, 1-12 (1996)). HDL is one ofthe major classes of lipoproteins that function in the transport of lipids through the blood. The major lipids found associated with HDL include cholesterol, cholesteryl ester, triglycerides, phospholipids and fatty acids. The other classes oflipoproteins found in the blood are low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Since low levels of HDL cholesterol increase the risk of atherosclerosis, methods for elevating plasma HDL cholesterol would be therapeuticallybeneficial for the treatment of atherosclerosis and other diseases associated with accumulation of lipid in the blood vessels. These diseases include, but are not limited to, coronary heart disease, peripheral vascular disease, and stroke.Atherosclerosis underlies most coronary artery disease (CAD), a major cause of morbidity and mortality in modem society. High LDL cholesterol (above 180 mg/dl) and low HDL cholesterol (below 35 mg/dl) have been shown to be important contributorsto the development of atherosclerosis. Other diseases, such as peripheral vascular disease, stroke, and hypercholesterolaemia are negatively affected by adverse HDL/LDL ratios. Inhibition of CETP by the subject compounds is shown to effectively modifyplasma HDL/LDL ratios, and to check the progress and/or formation of these diseases.CETP is a plasma protein that facilitates the movement of cholesteryl esters and triglycerides between the various lipoproteins in the blood (Tall, J. Lipid Res., 34, 1255-74 (1993)). The movement of cholesteryl ester from HDL to LDL by CETP hasthe effect of lowering HDL cholesterol. It therefore follows that inhibition of CETP should lead to elevation of plasma HDL cholesterol and lowering of plasma LDL cholesterol, thereby providing a therapeutically beneficial plasma lipid profile(McCarthy, Medicinal Res. Revs., 13, 139-59 (1993); Sitori, Pharmac. Ther., 67,443-47 (1995)). This exact phenomenon was first demonstrated by Swenson et al., (J. Biol. Chem., 264, 14318 (1989)) with the use of a monoclonal antibody that specificallyinhibited CETP. In rabbits, the antibody caused an elevation of the plasma HDL cholesterol and a decrease in LDL cholesterol. Son et al. (Biochim. Biophys. Acta 795, 743-480 (1984)), Morton et al. (J. Lipid Res. 35, 836-847 (1994)) and Tollefson etal. (Am. J. Physiol., 255, (Endocrinol. Metab. 18, E894-E902 (1988))) describe proteins from human plasma that inhibit CETP. U.S. Pat. No. 5,519,001, issued to Kushwaha et al., describes a 36 amino acid peptide derived from baboon apo C-1 thatinhibits CETP activity. Cho et al. (Biochim. Biophys. Acta 1391, 133-144 (1998)) describe a peptide from hog plasma that inhibits human CETP. Bonin et al. (J. Peptide Res., 51, 216-225 (1998)) disclose a decapeptide inhibitor of CETP. A depsipeptidefungal metabolite is disclosed as a CETP inhibitor by Hedge et al. in Bioorg. Med. Chem. Lett., 8, 1277-80 (1998).There have been several reports of non-peptidic compounds that act as CETP inhibitors. Barrett et al. (J. Am. Chem. Soc., 188, 7863-63 (1996)) and Kuo et al. (J. Am. Chem. Soc., 117, 10629-34 (1995)) describe cyclopropane-containing CETPinhibitors. Pietzonka et al. (Bioorg. Med. Chem. Lett, 6, 1951-54 (1996)) describe phosphonate-containing analogs of cholesteryl ester as CETP inhibitors. Coval et al. (Bioorg. Med. Chem. Lett., 5, 605-610 (1995)) describe Wiedendiol-A and -B, andrelated sesquiterpene compounds as CETP inhibitors. Japanese Patent Application No. 10287662-A describes polycyclic, non-amine containing, polyhydroxylic natural compounds possessing CETP inhibition properties. Lee et al. (J. Antibiotics, 49, 693-96(1996)) describe CETP inhibitors derived from an insect fungus. Busch et al. (Lipids, 25, 216-220, (1990)) describe cholesteryl acetyl bromide as a CETP inhibitor. Morton and Zilversmit (J. Lipid Res., 35, 836-47 (1982)) describe thatp-chloromercuriphenyl sulfonate, p-hydroxymercuribenzoate and ethyl mercurithiosalicylate inhibit CETP. Connolly et al. (Biochem. Biophys. Res. Comm. 223, 42-47 (1996)) describe other cysteine modification reagents as CETP inhibitors. Xia et al.describe 1,3,5-triazines as CETP inhibitors (Bioorg. Med. Chem. Lett., 6, 919-22 (1996)). Bisgaier et al. (Lipids, 29, 811-8 (1994)) describe 4-phenyl-5-tridecyl-4H-1,2,4-triazole-thiol as a CETP inhibitor. Oomura et al. disclose non-peptidictetracyclic and hexacyclic phenols as CETP inhibitors in Japanese Patent Application No. 10287662. In WO Patent Application No. 09914204, Sikorski describes 1,2,4-triazolylthiols useful as chlolesteryl ester transfer protein inhibitors.Some substituted heteroalkylamine compounds are known. In European Patent Application No. 796846, Schmidt et al. describe 2-aryl-substituted pyridines as cholesteryl ester transfer protein inhibitors useful as cardiovascular agents. Onesubstitutent at C3 of the pyridine ring can be an hydroxyalkyl group. In European Patent Application No. 801060, Dow and Wright describe heterocyclic derivatives substituted with an aldehyde addition product of an alkylamine to afford1-hydroxy-1-amines. These are reported to be β3-adrenergic receptor agonists useful for treating diabetes and other disorders. In Great Britain Patent Application No. 2305665, Fisher et al. disclose 3-agonist secondary amino alcohol substitutedpyridine derivatives useful for treating several disorders including cholesterol levels and artheroscierotic diseases. In European Patent Application No. 818448, Schmidt et al. describe tetrahydroquinoline derivatives as chlolesteryl ester transferprotein inhibitors. European Patent Application No. 818197, Schmek et al. describe pyridines with fused heterocycles as cholesteryl ester transfer protein inhibitors. Brandes et al. in German Patent Application No. 19627430 describe bicyclic condensedpyridine derivatives as cholesteryl ester transfer protein inhibitors. In WO Patent Application No. 09839299, Muller-Gliemann et al. describe quinoline derivatives as cholesteryl ester transfer protein inhibitors. U.S. Pat. No. 2,700,686, issued toDickey and Towne, describes N-(2-haloalkyl-2-hydroxyethyl)amines in which the amine is further substituted with either 1 to 2 aliphatic groups or one aromatic group and one aliphatic group. U.S. Pat. No. 2,700,686 further describes a process toprepare the N-(2-haloalkyl-2-hydroxyethyl)amines by reacting halogenated-1,2-epoxyalkanes with the corresponding aliphatic amines and N-alkylanilines and their use as dye intermediates.SUMMARY OF THE INVENTIONThe present invention provides compounds that can be used to inhibit cholesteryl ester transfer protein (CETP) activity and that have the general structure: ##STR2##In another aspect, the present invention includes pharmaceutical compositions comprising a pharmaceutically effective amount of the compounds of this invention and a pharmaceutically acceptable carrier.In another aspect, this invention relates to methods of using these inhibitors as therapeutic agents in humans to inhibit cholesteryl ester transfer protein (CETP) activity, thereby decreasing the concentrations of low density lipoprotein (LDL)and raising the level of high density lipoprotein (HDL), resulting in a therapeutically beneficial plasma lipid profile. The compounds and methods of this invention can also be used to treat dyslipidemia (hypoalphalipoproteinemia), hyperlipoproteinaemia(chyloricronemia and hyperapobetalipoproteinemia), peripheral vascular disease, hypercholesterolaemia, atherosclerosis, coronary artery disease and other CETP-mediated disorders. The compounds can also be used in prophylactic treatment of subjects whoare at risk of developing such disorders. The compounds can be used to lower the risk of atherosclerosis. The compounds of this invention would be also useful in prevention of cerebral vascular accident (CVA) or stroke. Besides being useful for humantreatment, these compounds are also useful for veterinary treatment of companion animals, exotic animals and farm animals such as primates, rabbits, pigs, horses, and the like.DESCRIPTION OF THE INVENTIONThe present invention relates to a class of compounds comprising substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines which are beneficial in the therapeutic and prophylactic treatment of coronary artery disease as given inFormula V-H (also referred to herein as generic substituted polycyclic aryl and heteroaryl tertiary omegaheteroalkylamines): ##STR3##or a pharmaceutically acceptable salt thereof, wherein; m is an integer selected from 0 through 5; n is an integer selected from 0 through 5; m plus n is an integer selected from 0 through 6; R1 is selected from the group consisting ofhaloalkyl, haloalkenyl, haloalkoxyalkyl, and haloalkenyloxyalkyl; X is selected from the group consisting of O, H, F, S, S(O), NH, N(OH), N(alkyl), and N(alkoxy); R16 is selected from the group consisting of hydrido, alkyl, alkenyl, alkynyl, aryl,aralkyl, aryloxyalkyl, alkoxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl,haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, monocarboalkoxyalkyl, monocarboalkoxy,dicarboalkoxyalkyl, monocarboxamido, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, dialkoxyphosphonoalkyl, trialkylsilyl, and a spacer selected from the group consisting of a covalent single bond and alinear spacer moiety having from 1 through 4 contiguous atoms linked to the point of bonding of an aromatic substituent selected from the group consisting of R4, R8, R9, R13, R14, and R15 to form a heterocyclyl ring havingfrom 5 through 10 contiguous members with the provisos that said spacer moiety is other than a covalent single bond when R2 is alkyl and there is no R16 wherein X is H or F; D1, D2, J1, J2 and K1 are independentlyselected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one of D1, D2, J1, J2 and K1 can be a covalent bond, no more than one of D1, D2, J1, J2 and K1 canbe O, no more than one of D1, D2, J1, J2 and K1 can be S, one of D1, D2, J1, J2 and K1 must be a covalent bond when two of D1, D2, J1, J2 and K1 are O and S, and no more than fourof D1, D2, J1, J2 and K1 can be N; D3, D4, J3, J4 and K2 are independently selected from the group consisting of C, N, O, S and a covalent bond with the provisos that no more than one of D3, D4,J3, J4 and K2 can be a covalent bond, no more than one of D3, D4, J3, J4 and K2 can be O, no more than one of D3, D4, J3, J4 and K2 can be S, one of D3, D4, J3, J4 andK2 must be a covalent bond when two of D3, D4, J3, J4 and K2 are O and S, and no more than four of D3, D4, J3, J4 and K2 can be N; R2 is independently selected from the group consisting ofhydrido, hydroxy, hydroxyalkyl, amino, aminoalkyl, alkylamino, dialkylamino, alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkoxyalkyl, aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, aralkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl,alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl,cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy,dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl, and diaralkoxyphosphonoalkyl; R2 and R3 can be taken together to form a linear spacer moiety selected from the group consisting of a covalent single bond and a moiety having from 1through 6 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl having from 3 through 8 contiguous members, a cycloalkenyl having from 5 through 8 contiguous members, and a heterocyclyl having from 4 through 8 contiguousmembers; R2 and R14 can be taken together to form a linear spacer moiety selected from the group consisting of a covalent bond and a linear spacer moiety having from 1 through 5 contiguous atoms to form a heterocyclyl ring having from 5 through8 contiguous members with the proviso that said spacer group is other than --N=; R2 and R15 can be taken together to form a linear spacer moiety selected from the group consisting of a covalent bond and a linear spacer moiety having from 1through 5 contiguous atoms to form a heterocyclyl ring having from 5 through 8 contiguous members with the proviso that said spacer group is other than --N=; R2 and R19 can be taken together to form a linear spacer moiety selected from thegroup consisting of a covalent single bond and a linear moiety having from 1 through 5 contiguous atoms to form a ring selected from the group consisting of a cycloalkyl having from 3 through 8 contiguous members, a cycloalkylenyl having from 5 through8 contiguous members, and a heterocyclyl having from 4 through 8 contiguous members; R2 and R4, R2 and R8, R2 and R9, and R2 and R13 can be independently selected to form spacer pairs wherein a spacer pair is takentogether to form a linear spacer moiety wherein said linear spacer moiety is selected to form a heterocyclyl ring having from 5 through 10 contiguous members; R3 is selected from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy,hydroxyalkyl, amino, alkylamino, dialkylamino, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl, heteroarylthio, aralkylthio, aralkoxyalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, aroyl, heteroaroyl, aralkylthioalkyl, heteroaralkylthioalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl,halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl,monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, aryl sulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl,aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy,carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl, and diaralkoxyphosphonoalkyl; R3 and R14 can be taken together to form a linear spacer moiety selected fromthe group consisting of a covalent bond and a linear moiety having from 1 through 5 atoms to form a heterocyclyl ring having from 5 through 8 contiguous members; R3 and R15 can be taken together to form a linear spacer moiety selected from thegroup consisting of a covalent bond and a linear moiety having from 1 through 5 atoms to form a heterocyclyl ring having from 5 through 8 contiguous members; R3 and R19 can be taken together to form a linear spacer moiety selected from thegroup consisting of a covalent single bond and a linear moiety having a chain length of 1 to 5 atoms to form a ring selected from the group consisting of a cycloalkyl having from 3 through 8 contiguous members, a cycloalkylenyl having from 5 through 8contiguous members, and a heterocyclyl having from 4 through 8 contiguous members; R3 and R4, R3 and R8, R3 and R9, and R3 and R13 can be independently selected to form spacer pairs wherein a spacer pair is takentogether to form a linear spacer moiety wherein said linear spacer moiety is selected to form a heterocyclyl ring having from 5 through 10 contiguous members; Y is selected from a group consisting of a covalent single bond, (C(R14)2)qwherein q is an integer selected from 1 through 4 and (CH(R14))g --W--(CH(R14))p wherein g and p are integers independently selected from 0 through 2;R14 is independently selected from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy, amino, alkylamino, dialkylamino, hydroxyalkyl, acyl, aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl, acylamido, alkoxy, alkylthio,arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkylalkoxy, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkoxythioalkyl, alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl,heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl,diaralkoxyphosphonoalkyl, a spacer selected from a moiety having a chain length of 3 to 6 atoms connected to the point of bonding selected from the group consisting of R9 and R13 to form a ring selected from the group consisting of acycloalkenyl ring having from 5 through 8 contiguous members and a heterocyclyl ring having from 5 through 8 contiguous members, and a spacer selected from a moiety having a chain length of 2 to 5 atoms connected to the point of bonding selected from thegroup consisting of R4 and R8 to form a heterocyclyl having from 5 through 8 contiguous members with the proviso that, when Y is a covalent bond, an R14 substituent is not attached to Y; R14 and R15 can be taken together to forma spacer selected from a moiety having a chain length of 2 to 5 atoms to form a heterocyclyl ring having from 5 through 8 contiguous members; R14 and R19 can be taken together to form a spacer selected from a moiety having a chain length of 2to 5 atoms to form a heterocyclyl ring having from 5 through 8 contiguous members; R14 and R14, when bonded to the different atoms, can be taken together to form a group selected from the group consisting of a covalent bond, alkylene,haloalkylene, and a spacer selected from a group consisting of a moiety having a chain length of 2 to 5 atoms connected to form a ring selected from the group of a saturated cycloalkyl having from 5 through 8 contiguous members, a cycloalkenyl havingfrom 5 through 8 contiguous members, and a heterocyclyl having from 5 through 8 contiguous members; R14 and R14, when bonded to the same atom can be taken together to form a group selected from the group consisting of oxo, thiono, alkylene,haloalkylene, and a spacer selected from the group consisting of a moiety having a chain length of 3 to 7 atoms connected to form a ring selected from the group consisting of a cycloalkyl having from 4 through 8 contiguous members, a cycloalkenyl havingfrom 4 through 8 contiguous members, and a heterocyclyl having from 4 through 8 contiguous members; W is selected from the group consisting of O, C(O), C(S), C(O)N(R14), C(S)N(R14), (R14)NC(O), (R14)NC(S), S, (O), S(O)2,S(O)2 N(R14), (R14)NS(O)2, and N(R14) with the proviso that R14 is selected from other than halo and cyano; Z is independently selected from a group consisting of a covalent single bond, (C(R15)2)q wherein qis an integer selected from 1 through 4, (CH(R15))j --W--(CH(R15))k wherein j and k are integers independently selected from 0 through 2 with the proviso that, when Z is a covalent single bond, an R15 substituent is not attachedto Z; R15 is independently selected, when Z is (C(R15)2)q wherein q is an integer selected from 1 through 4, from the group consisting of hydrido, hydroxy, halo, cyano, aryloxy, amino, alkylamino, dialkylamino, hydroxyalkyl, acyl,aroyl, heteroaroyl, heteroaryloxyalkyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl,alkoxyalkyl, heteroaryloxyalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl,haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl,monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl,cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxy, carboxyalkyl, carboalkoxy, carboxamide,carboxamidoalkyl, carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl, a spacer selected from a moiety having a chain length of 3 to 6 atoms connected to the point of bonding selected from the groupconsisting of R4 and R8 to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguous members and a heterocyclyl ring having from 5 through 8 contiguous members, and a spacer selected from a moietyhaving a chain length of 2 to 5 atoms connected to the point of bonding selected from the group consisting of R9 and R13 to form a heterocyclyl having from 5 through 8 contiguous members; R15 and R19 can be taken together to form aspacer selected from the group consisting of a covalent single bond and a linear moiety having a chain length of 2 to 5 atoms to form a heterocyclyl ring having from 5 through 8 contiguous members; R15 and R15, when bonded to the differentatoms, can be taken together to form a group selected from the group consisting of a covalent bond, alkylene, haloalkylene, and a spacer selected from a group consisting of a moiety having a chain length of 2 to 5 atoms connected to form a ring selectedfrom the group of a saturated cycloalkyl having from 5 through 8 contiguous members, a cycloalkenyl having from 5 through 8 contiguous members, and a heterocyclyl having from 5 through 8 contiguous members; R15 and R15, when bonded to the sameatom can be taken together to form a group selected from the group consisting of oxo, thiono, alkylene, haloalkylene, and a spacer selected from the group consisting of a moiety having a chain length of 3 to 7 atoms connected to form a ring selected fromthe group consisting of a cycloalkyl having from 4 through 8 contiguous members, a cycloalkenyl having from 4 through 8 contiguous members, and a heterocyclyl having from 4 through 8 contiguous members; R15 is independently selected, when Z is(CH(R15))j --W--(CH(R15))k wherein j and k are integers independently selected from 0 through 2, from the group consisting of hydrido, halo, cyano, aryloxy, carboxyl, acyl, aroyl, heteroaroyl, hydroxyalkyl, heteroaryloxyalkyl,acylarnido, alkoxy, alkylthio, arylthio, alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, alkoxyalkyl, heteroaryloxyalkyl, aralkoxyalkyl, heteroaralkoxyalkyl, alkylsulfonylalkyl, alkylsulfinylalkyl, alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl,cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxyalkyl,perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl, carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl,haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl, cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl,heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl, carboaralkoxy, dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl, a spacer selected froma linear moiety having a chain length of 3 to 6 atoms connected to the point of bonding selected from the group consisting of R4 and R8 to form a ring selected from the group consisting of a cycloalkenyl ring having from 5 through 8 contiguousmembers and a heterocyclyl ring having from 5 through 8 contiguous members, and a spacer selected from a linear moiety having a chain length of 2 to 5 atoms connected to the point of bonding selected from the group consisting of R9 and R13 toform a heterocyclyl ring having from 5 through 8 contiguous members; R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are independently selected from the group consisting of perhaloaryloxy, alkanoylalkyl,alkanoylalkoxy, alkanoyloxy, N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-alkylcarboxamido, N-haloalkylcarboxamido,N-cycloalkylcarboxamido, N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, hydrido, carboxy, heteroaralkylthio, heteroaralkoxy, cycloalkylarnino, acylalkyl, acylalkoxy, aroylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl,aralkenyl, aralkynyl, heterocyclyl, perhaloaralkyl, aralkylsulfonyl, aralkylsulfonylalkyl, aralkylsulfinyl, aralkylsulfinylalkyl, halocycloalkyl, halocycloalkenyl, cycloalkylsulfinyl, cycloalkylsulfinylalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl,heteroarylamino, N-heteroarylamino-N-alkylamino, heteroarylaminoalkyl,haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, haloalkoxylalkyl, heteroaralkoxy, cycloalkoxy, cycloalkenyloxy, cycloalkoxyalkyl, cycloalkylalkoxy, cycloalkenyloxyalkyl,cycloalkylenedioxy, halocycloalkoxy, halocycloalkoxyalkyl, halocycloalkenyloxy, halocycloalkenyloxyalkyl, hydroxy, amino, thio, nitro, lower alkylamino, alkylthio, alkylthioalkyl, arylarnino, aralkylamino, arylthio, arylthioalkyl, heteroaralkoxyalkyl,alkylsulfinyl, alkylsulfinylalkyl, arylsulfinylalkyl, arylsulfonylalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, alkylsulfonyl, alkylsulfonylalkyl, haloalkylsulfinylalkyl, haloalkylsulfonylalkyl, alkylsulfonamido, alkylaminosulfonyl,amidosulfonyl, monoalkyl amidosulfonyl, dialkyl amidosulfonyl, monoarylamidosulfonyl, arylsulfonamido, diarylamidosulfonyl, monoalkyl monoaryl amidosulfonyl, arylsulfinyl, arylsulfonyl, heteroarylthio, heteroarylsulfinyl, heteroarylsulfonyl,heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, heteroaroyl, aralkanoyl, heteroaralkanoyl, haloalkanoyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkenyloxyalky, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl,cycloalkenyl, lower cycloalkylalkyl, lower cycloalkenylalkyl, halo, haloalkyl, haloalkenyl, haloalkoxy, hydroxyhaloalkyl, hydroxyaralkyl, hydroxyalkyl, hydoxyheteroaralkyl, haloalkoxyalkyl, aryl, heteroaralkynyl, aryloxy, aralkoxy, aryloxyalkyl,saturated heterocyclyl, partially saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkenyl, heteroarylalkenyl, carboxyalkyl, carboalkoxy, alkoxycarboxamido, alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl,carboalkoxyalkenyl, carboaralkoxy, carboxamido, carboxamidoalkyl, cyano, carbohaloalkoxy, phosphono, phosphonoalkyl, diaralkoxyphosphono, and diaralkoxyphosphonoalkyl with the proviso that there are one to five non-hydrido ring substituents R4,R5, R6, R7, and R8 present, that there are one to five non-hydrido ring substituents R9, R10, R11, R12, and R13 present, and R4, R5, R6, R7, R8, R9, R10, R11, R12,a R13 are each independently selected to maintain the tetravalent nature of carbon, trivalent nature of nitrogen, the divalent nature of sulfur, and the divalent nature of oxygen; R4 and R5, R5 and R6, R6 and R7,R7 and R8, R9 and R10, R10 and R11, R11 and R12, and R12 and R13 can be independently selected to form spacer pairs wherein a spacer pair is taken together to form a linear moiety having from 3 through 6contiguous atoms connecting the points of bonding of said spacer pair members to form a ring selected from the group consisting of a cycloalkenyl ring having 5 through 8 contiguous members, a partially saturated heterocyclyl ring having 5 through 8contiguous members, a heteroaryl ring having 5 through 6 contiguous members, and an aryl with the provisos that no more than one of the group consisting of spacer pairs R4 and R5, R5 and R6, R6 and R7, and R7 andR8, can be used at the same time and that no more than one of the group consisting of spacer pairs R9 and R10, R10 and R11, R11 and R12, and R12 and R13 can be used at the same time; R4 and R9,R4 and R13, R8 and R9, and R8 and R13 can be independently selected to form a spacer pair wherein said spacer pair is taken together to form a linear moiety wherein said linear moiety forms a ring selected from the groupconsisting of a partially saturated heterocyclyl ring having from 5 through 8 contiguous members and a heteroaryl ring having from 5 through 6 contiguous members with the proviso that no more than one of the group consisting of spacer pairs R4 andR9, R4 and R13, R8 and R9, and R8 and R13 can be used at the same time; R5 and R10, R5 and R12, R7 and R10, and R7 and R12 can be independently selected to form a spacer pairwherein said spacer pair is taken together to form a linear moiety wherein said linear moiety forms a C8 to C13 heterocyclyl ring having from 8 through 13 contiguous members with the proviso that no more than one of the group consisting of spacer pairsR5 and R10, R5 and R12, R7 and R10, and R7 and R12 can be used at the same time; R19 is selected from the group consisting of hydrido, hydroxyalkyl, acyl, sulfhydryl, acylamido, alkoxy, alkylthio, arylthio,alkyl, alkenyl, alkynyl, aryl, aralkyl, aryloxyalkyl, aralkanoyl, heteroarylthio, aralkylthio, aroyl, heteroaroyl, aralkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aralkylthioalkyl, heteroaralkylthioalkyl, alkoxyalkyl, heteroaryloxyalkyl,alkenyloxyalkyl, alkylthioalkyl, arylthioalkyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkenyl, cycloalkenylalkyl, haloalkyl, haloalkenyl, halocycloalkyl, halocycloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy,halocycloalkoxyalkyl, halocycloalkenyloxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, heteroarylalkyl, heteroarylthioalkyl, heteroaralkylthioalkyl, monocarboalkoxyalkyl, dicarboalkoxyalkyl, monocyanoalkyl, dicyanoalkyl,carboalkoxycyanoalkyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfinyl, haloalkylsulfonyl, arylsulfinyl, arylsulfinylalkyl, arylsulfonyl, arylsulfonylalkyl, aralkylsulfinyl, aralkylsulfonyl, cycloalkylsulfinyl, cycloalkylsulfonyl,cycloalkylsulfinylalkyl, cycloalkylsufonylalkyl, heteroarylsulfonylalkyl, heteroarylsulfinyl, heteroarylsulfonyl, heteroarylsulfinylalkyl, aralkylsulfinylalkyl, aralkylsulfonylalkyl, carboxyalkyl, carboalkoxy, carboxamide, carboxamidoalkyl,carboaralkoxy, dialkoxyphosphono, diaralkoxyphosphono, dialkoxyphosphonoalkyl, diaralkoxyphosphonoalkyl, and a spacer group selected from the group consisting of a covalent single bond and a linear moiety having a chain length of 2 to 5 atoms connectedto a point of bonding selected from the group consisting of R4, R8, R9, and R13 to form a heterocyclyl ring having from 5 through 8 contiguous members.In another embodiment, the compounds correspond to Formula V-H wherein m is an integer selected from 0 through 5; n is an integer selected from 0 through 5; the sum of m plus n is an integer selected from 0 through 6; D1, D2, D3,D4, J1, J2, J3, J4, K1, and K2 are each a carbon atom; and a terminal carbon atom of the CH(R3) moiety is directly connected by a covalent single bond to the nitrogen when m=0. Compounds of Formula V-H whereinm is an integer selected from 0 through 5, n is an integer selected from 0 through 5, the sum of m plus n is an integer selected from 0 through 6, and D1, D2, D3, D4, J1, J2, J3, J4, K1, and K2 are each acarbon atom, have the CH(R3) moiety directly connected by a covalent single bond to the nitrogen when m=0 and correspond to Formula V (also referred to herein as generic phenyl tertiary omegaheteroalkylamines): ##STR4##or a pharmaceutically acceptable salt thereof, wherein; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R19, X, Y, and Z are as definedfor the compounds of Formula V-H; D1, D2, D3, D4, J1, J2, J3, J4, K1, and K2 are each carbon; R16 and R4, R16 and R8, R16 and R9, R16 and R13, R2 and R3,R9 and R14, R13 and R14, R4 and R14, R8 and R14, R14 and R14, R4 and R15, R8 and R15, R9 and R15, R13 and R15, R15 and R15, R4 and R5, R5and R6, R6 and R7, R7 and R8, R9 and R10, R10 and R11, R11 and R12, R12 and R13, R4 and R9, R4 and R13, R8 and R9, R8 and R13, R16 and R14,R16 and R15, R2 and R14, R2 and R15, R2 and R19, R2 and R4, R2 and R8, R2 and R9, R2 and R13, R3 and R14, R3 and R15, R3 and R19, R3 andR4,R3 and R8, R3 and R9, R3 and R13, R14 and R19, R14 and R15, R15 and R19, R5 and R10, R5 and R12, R7 and R10, and R7 and R12 spacer pairs are asdefined for the compounds of Formula V-H.In another embodiment, the compounds correspond to Formula V-H wherein m is an integer selected from 0 through 5; n is an integer selected from 0 through 5; the sum of m plus n is an integer selected from 0 through 6; and a terminal carbon atomof the CH(R3) moiety is directly connected by a covalent single bond to the nitrogen when m=0. Compounds of Formula V-H wherein m is the integer zero, and n is an integer selected from 0 through 5, have the CH(R3) moiety directly connectedby a covalent single bond to the nitrogen when m=0 and correspond to Formula VII-H (also referred to herein as generic substituted polycyclic heteroaryl tertiary 2-heteroalkylarines): ##STR5##or a pharmaceutically acceptable salt thereof, wherein; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, D1, D2, D3, D4,J1, J2, J3, J4, K1, K2, X, Y, and Z are as defined for the compounds of Formula V-H; R16 and R4, R16 and R8, R16 and R9, R16 and R13, R2 and R3, R9 and R14,R13 and R14, R4 and R14, R8 and R14, R14 and R14, R4 and R15, R8 and R15, R9 and R15, R13 and R15, R15 and R15, R4 and R5, R5 and R6, R6and R7, R7 and R8, R9 and R10, R10 and R11, R11 and R12, R12 and R13, R4 and R9, R4 and R13, R8 and R9, and R8 and R13 spacer pairs are as defined for thecompounds of Formula V-H; R19 and spacer pairs R16 and R14, R16 and R15, R2 and R14, R2 and R15, R2 and R19, R2 and R4, R2 and R8, R2 and R9, R2 and R13,R3 and R14, R3 and R15, R3 and R19, R3 and R4, R3 and R8, R3 and R9, R3 and R13, R14 and R19, R14 and R15, R15 and R19, R5 and R10, R5 andR12, R7 and R10, and R7 and R12 are not presentIn another embodiment of compounds of Formula VII-H, D1, D2, J1, J2 and K1 are each carbon with the proviso that at least one of D3, D4, J3, J4 and K2 is selected from the group consisting of O,S, and N, wherein D3, D4, J3, J4 and K2 are independently selected from the group consisting of C, N, O, S and covalent bond with the provisos that no more than one of D3, D4, J3, J4 and K2 can be acovalent bond, no more than one of D3, D4, J3, J4 and K2 can be O, no more than one of D3, D4, J3, J4 and K2 can be S, one of D3, D4, J3, J4 and K2 must be a covalent bond whentwo of D3, D4, J3, J4 and K2 are O and S, and no more than four of D3, D4, J3, J4 and K2 can be N; D1, D2, J1, J2 and K1 can be selected from the group consisting of C, O, S, Nand covalent bond with the provisos that D3, D4, J3, J4 and K2 are each carbon and at least one of D1, D2, J1, J2 and K1 is selected from the group consisting of O, S, and N wherein, when D1,D2, J1, J2 and K1 are selected from the group consisting of C, O, S, covalent bond, and N, no more than one of D1, D2, J1, J2 and K1 can be a covalent bond, no more than one of D1, D2, J1,J2 and K1 can be O, no more than one of D1, D2, J1 J2 and K1 can be S, one of D1, D2, J1, J2 and K1 must be a covalent bond when two of D1, D2, J1, J2 and K1 are O andS, and no more than four of D1, D2, J1, J2 and K1 can be N; n is an integer selected from 1 through 4; X is oxy; R16 is selected from the group consisting of hydrido, acyl, aroyl, and trialkylsilyl; R1 is selected fromthe group consisting of haloalkyl, haloalkenyl, haloalkoxyalkyl, and haloalkenyloxyalkyl; R2 is selected from the group consisting of hydrido, hydroxy, aryl, aralkyl, alkyl, alkenyl, alkenyloxyalkyl, haloalkyl, haloalkenyl, halocycloalkyl,haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, halocycloalkoxy, halocycloalkoxyalkyl, perhaloaryl, perhaloaralkyl, perhaloaryloxyalkyl, heteroaryl, dicyanoalkyl, and carboalkoxycyanoalkyl; R3 is selected from the group consisting of hydrido,hydroxy, cyano, aryl, aralkyl, acyl, alkoxy, alkyl, alkenyl, alkoxyalkyl, heteroaryl, alkenyloxyalkyl, haloalkyl, haloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, monocyanoalkyl, dicyanoalkyl, carboxamide, and carboxamidoalkyl; Y isselected from the group consisting of covalent single bond and (C(R14)2)q wherein q is an integer selected from 1 through 2; R14 is selected from the group consisting of hydrido, cyano, hydroxyalkyl, acyl, alkoxy, alkyl, alkenyl,alkoxyalkyl, haloalkyl, haloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, monocyanoalkyl, dicyanoalkyl, carboxamide, and carboxamidoalkyl; Z is selected from the group consisting of covalent single bond, (C(R15)2)q wherein qis an integer selected from 1 through 2, and (CH(R15))j --W--(CH(R15))k wherein j and k are integers independently selected from 0 through 2; W is oxy; R15 is selected from the group consisting of hydrido, cyano, hydroxyalkyl,acyl, alkoxy, alkyl, alkenyl, alkoxyalkyl, haloalkyl, haloalkenyl, haloalkoxy, haloalkoxyalkyl, haloalkenyloxyalkyl, monocyanoalkyl, dicyanoalkyl, carboxamide, and carboxamidoalkyl; R4, R8, R9, and R13 are independently selected fromthe group consisting of hydrido, halo, haloalkyl, and alkyl R5, R6, R7, R10, R11, and R12 are independently selected from the group consisting of perhaloaryloxy, alkanoylalkyl, alkanoylalkoxy, alkanoyloxy,N-aryl-N-alkylamino, heterocyclylalkoxy, heterocyclylthio, hydroxyalkoxy, carboxamidoalkoxy, alkoxycarbonylalkoxy, alkoxycarbonylalkenyloxy, aralkanoylalkoxy, aralkenoyl, N-alkylcarboxamido, N-haloalkylcarboxamido, N-cycloalkylcarboxamido,N-arylcarboxamidoalkoxy, cycloalkylcarbonyl, cyanoalkoxy, heterocyclylcarbonyl, hydrido, carboxy, heteroaralkylthio, heteroarylsulfonyl, heteroaralkoxy, cycloalkylamino, acylalkyl, acylalkoxy, aroylalkoxy, heterocyclyloxy, aralkylaryl, aralkyl,aralkenyl, aralkynyl, heterocyclyl, haloalkylthio, alkanoyloxy, alkoxy, alkoxyalkyl, cycloalkoxy, cycloalkylalkoxy, hydroxy, amino, thio, nitro, lower alkylamino, alkylthio, arylamino, aralkylamino, arylthio, arylthioalkyl,alkylsulfonyl,alkylsulfonamido, monoarylamidosulfonyl, arylsulfonyl, heteroarylthio, heterocyclylsulfonyl, heterocyclylthio, alkanoyl, alkenoyl, aroyl, alkyl, alkenyl, alkynyl, alkenyloxy, alkylenedioxy, haloalkylenedioxy, cycloalkyl, cycloalkylalkanoyl, halo,haloalkyl, haloalkoxy, hydroxyhaloalkyl, hydroxyalkyl, aryl, aralkyl, aryloxy, aralkoxy, saturated heterocyclyl, heteroaryl, heteroaryloxy, heteroaryloxyalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, carboalkoxy, alkoxycarboxamido,alkylamidocarbonylamido, arylamidocarbonylamido, carboalkoxyalkyl, carboalkoxyalkenyl, carboxamido, carboxamidoalkyl, and cyano; R4 and R5, R5 and R6, R6 and R7, R7 and R8, R9 and R10, R10 andR11, R11 and R12, and R12 and R13 spacer pairs can be independently selected from the group consisting of alkylene, alkenylene, alkylenedioxy, aralkylene, diacyl, haloalkylene, and aryloxylene with the provisos that no more thanone of the group consisting of spacer pairs R4 and R5, R5 and R6, R6 and R7, and R7 and R8 can be used at the same time and that no more than one of the group consisting of spacer pairs R9 and R10,R10 and R11, R11 and R12, and R12 and R13 can be used at the same time.In a more specific embodiment of compounds of Formula VII-H, D1, D2, J1, J2 and K1 are each carbon; D3, D4, J3, J4 and K2 are independently selected from the group consisting of C, N, O, S andcovalent bond with the provisos that at least one of D3, D4, J3, J4 and K2 is selected from the group consisting of O, S, and N, wherein no more than one of D3, D4, J3, J4 and K2 can be a covalent bond,no more than one of D3, D4, J3, J4 and K2 can be O, no more than one of D3, D4, J3, J4 and K2 can be S, one of D3, D4, J3, J4 and K2 must be a covalent bond when two of D3,D4, J3, J4 and K2 are O and S, and no more than four of D3, D4, J3, J4 and K2 can be N; n is an integer selected from 1 through 3; X is oxy; R1 is selected from the group consisting of trifluoromethyl,1,1,2,2-tetrafluoroethoxymethyl, trifluoromethoxymethyl, chloromethyl, fluoromethyl, difluoromethyl, chlorodifluoromethyl, pentafluoroethyl, 2,2,3,3,3-pentafluoropropyl, and heptafluoropropyl; R16 is selected from the group consisting of acetyl,benzoyl, dimethyl tert-butylsilyl, hydrido, and trimethylsilyl; R2 is selected from the group consisting of hydrido, hydroxy, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, vinyl, phenyl, trifluoromethyl, 4trifluoromethylphenyl,1,1,2,2-tetrafluoroethoxymethyl, chloromethyl, trifluoromethoxymethyl, fluoromethyl, difluoromethyl, chlorodifluoromethyl, pentafluoroethyl, 2,2,3,3,3-pentafluoropropyl, and heptafluoropro