Source: http://www.google.com/patents/US20050192627?dq=5,973,252
Timestamp: 2015-02-01 13:52:58
Document Index: 141721315

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'art 10', 'art 10', 'art 10', 'art 10']

Patent US20050192627 - Patent foramen ovale closure devices, delivery apparatus and related methods ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe present invention includes systems, methods, and apparatus configured to close an internal tissue opening, such as an internal tissue opening cased by an atrial septal defect including a patent foramen ovale defect, ventricular septal defect, patent ductus arterosus defect, or the like. For example,...http://www.google.com/patents/US20050192627?utm_source=gb-gplus-sharePatent US20050192627 - Patent foramen ovale closure devices, delivery apparatus and related methods and systemsAdvanced Patent SearchPublication numberUS20050192627 A1Publication typeApplicationApplication numberUS 11/102,095Publication dateSep 1, 2005Filing dateApr 8, 2005Priority dateOct 10, 2003Also published asCA2608769A1, EP1871240A2, EP1871240A4, WO2006110147A2, WO2006110147A3Publication number102095, 11102095, US 2005/0192627 A1, US 2005/192627 A1, US 20050192627 A1, US 20050192627A1, US 2005192627 A1, US 2005192627A1, US-A1-20050192627, US-A1-2005192627, US2005/0192627A1, US2005/192627A1, US20050192627 A1, US20050192627A1, US2005192627 A1, US2005192627A1InventorsBrian Whisenant, Clark Davis, Daryl EdmistonOriginal AssigneeWhisenant Brian K., Davis Clark C., Edmiston Daryl R.Export CitationBiBTeX, EndNote, RefManReferenced by (18), Classifications (15), Legal Events (2) External Links: USPTO, USPTO Assignment, EspacenetPatent foramen ovale closure devices, delivery apparatus and related methods and systemsUS 20050192627 A1Abstract The present invention includes systems, methods, and apparatus configured to close an internal tissue opening, such as an internal tissue opening cased by an atrial septal defect including a patent foramen ovale defect, ventricular septal defect, patent ductus arterosus defect, or the like. For example, a closure device includes a right anchor cooperatively coupled with a left anchor, where the right anchor and left anchor are configured to be positioned about the internal tissue opening. The left and/or right anchor are configured to close the internal tissue opening in one instance, and to provide tissue stimulating or growth-encouraging substances at the tissue opening. Additional aspects of the invention relate to shape, formation, positioning, and detachment of the closure device about the internal tissue opening. Images(34) Claims(22)
1. A method for facilitating closure of an internal tissue using a closure device, comprising the following: deploying a left anchor of a closure device about one side of a tissue opening that is to be closed; deploying a right anchor of the closure device about an opposing side of the tissue opening that is to be closed; and partially detaching the closure device, such that control is still maintained of a distal hub of the right anchor via attachment of a flexible filament to a distal hub of the right anchor. 2. The method as recited in claim 1, further comprising viewing the position of the right anchor about the tissue opening. 3. The method as recited in claim 2, further comprising reattaching the stem with the proximal hub based on the viewed position of the right anchor. 4. The method as recited in claim 2, wherein partially detaching the closure device comprises detaching the stem from the proximal hub, while maintaining attachment of a flexible filament with the distal hub. 5. The method as recited in claim 2, further comprising detaching a flexible filament from the distal hub. 6. The method as recited in claim 5, wherein the flexible filament and the stem are detached by unscrewing the flexible filament or the stem from corresponding threads at the distal hub or the proximal hub respectively. 7. The method as recited in claim 1, wherein the right anchor comprises three or more anchor members, and wherein the three or more anchor members independently conform to one or more surfaces about the tissue opening. 8. The method as recited in claim 1, wherein the tissue opening is any caused by PFO, ASD, VSD, or PDA. 9. A closure device configured to close an internal tissue opening, comprising: a right anchor connected to a left anchor by a connector, the right anchor having three or more right anchor members extending from two or more right anchor hubs, one of the one or more right anchor hubs being moveable relative to the left anchor; and a stem detachably coupled to one of the two or more right anchor hubs. 10. The closure device as recited in claim 9, wherein the left anchor and right anchor are atrial anchors configured to be positioned about atrial tissue. 11. The closure device as recited in claim 9, further comprising a growth stimulating substance positioned about one or more of the left anchor and the right anchor. 12. The closure device as recited in claim 10, wherein the growth stimulating substance comprises one or more of DACRON fiber, resorbable polymer, growth protein, and a drug-eluting composition. 13. The closure device as recited in claim 9, wherein the stem is reversibly detachable to a proximal hub, and wherein the right anchor further comprises a flexible filament that is reversibly detachable to a distal hub. 14. The closure device as recited in claim 13, wherein the flexible filament can be positioned at two or more points inside the stem. 15. The closure device as recited in claim 13, wherein the flexible filament is reversibly detachable to the distal hub via one or more threads, and wherein the stem is reversibly detachable to the proximal hub via one or more threads, such that the stem and flexible filament can be attached by rotating in one direction, and can be detached by rotating in an opposite direction. 16. The closure device as recited in claim 9, wherein the right anchor further comprises a top central hub that on a fixed position of a longitudinal axis, and a lower central hub that can be variably positioned on the longitudinal axis. 17. The closure device as recited in claim 16, wherein the three or more filaments directly connect the top central hub and the lower central hub, such that the three or more filaments form three or more right anchor members when the top central hub and the lower central hub are positioned close together. 18. The closure device as recited in claim 16, wherein a filament is threaded through each of three or more extensions in the top central hub and in three or more extensions in the lower central hub, such that a top set of loops and a lower set of loops are formed. 19. The closure device as recited in claim 18, wherein the top set of loops are attached to the lower set of loops to form a set of three or more substantially independent right anchor members. 20. A closure device configured to close an internal tissue opening, comprising: a left anchor having three or more left anchor members extending from one or more left anchor hubs; a right anchor connected to the left anchor, the right anchor having three or more right anchor members extending from one or more right anchor hubs; and partial detachment means configured for at least partially and reversibly detaching the right anchor from a stem, such that a minimum of control can be maintained over the right anchor despite partial detachment from an insertion device, and such that a user can view the position of the right anchor while maintaining the ability to easily recapture the right anchor and reposition the right anchor if appropriate. 21. The closure device as recited in claim 19, wherein the partial detachment means comprise a stem that is coupled to one of the one or more right anchor hubs via corresponding threads, and a flexible filament that is coupled to another of the one or more right anchor hubs via corresponding threads. 22. The closure device as recited in claim 19, wherein the flexible filament is threaded through the stem.
CROSS-REFERENCE TO RELATED APPLICATIONS The present invention is a continuation-in-part of U.S. patent application Ser. No. 10/964,311, filed on Oct. 12, 2004, entitled �PATENT FORAMEN OVALE (PFO) CLOSURE DEVICES, DELIVERY APPARATUS AND RELATED METHODS AND SYSTEMS�, which claims the benefit of U.S. Provisional Patent Application No. 60/530,866, filed on Dec. 17, 2003, entitled �COUPLED PATENT FORAMEN OVALE (PFO) CLOSURE APPARATUS AND RELATED METHODS AND SYSTEMS�; U.S. Provisional Patent Application No. 60/510,263, filed on Oct. 10, 2003, entitled �INTEGRAL PATENT FORAMEN OVALE (PFO) CLOSURE DEVICES AND RELATED METHODS AND SYSTEMS�; and U.S. Provisional Patent Application No. 60/510,203, filed on Oct. 10, 2003, entitled �COUPLEABLE PATENT FORAMEN OVALE (PFO) CLOSURE APPARATUS AND RELATED METHODS AND SYSTEMS�. The entirety of each of the aforementioned patent applications is incorporated by reference herein.
BACKGROUND OF THE INVENTION 1. The Field of the Invention The present invention relates generally to implanting medical devices within a patient. More specifically, the present invention relates to closure of a septal defect or the like between the right and left atria of a patient's heart (or similarly configured opening of another tissue). 2. Background Patent foramen ovale (�PFO�), is a birth defect that occurs when an opening between the upper two chambers of the heart fail to close after birth to a lesser or greater degree. This birth defect is sometimes also known as a �hole in the heart�. In less severe cases, patients will survive into adulthood without any significant symptoms; while in more severe cases, the afflicted can suffer shortness of breath, heart murmurs or other arrhythmia, and so on. Other problems with this condition are that a blood clot may travel freely between the left or right atria of the heart, and end up on the arterial side. This could allow the clot to travel to the brain, or other organs, and cause embolization, or even a heart attack. These and other similar defects (septal or otherwise), where some tissue needs to be closed to function properly include the general categories of atrial septal defects (�ASDs�), ventricular septal defects (�VSCs�) and patent ductus arterosus (�PDA�), and so forth. Conventional treatments for PFO (and related conditions), have generally involved invasive surgery, which presents a different, new set of risks to a patient. Although there are some less invasive treatments for PFO, these have typically been less efficient at closing the PFO opening than techniques involving invasive surgery. BRIEF SUMMARY OF THE INVENTION The present invention solves one or more problems in the prior art with systems, methods, and apparatus that can close an internal tissue opening, which should otherwise be closed for proper functioning, and to stimulate tissue growth about the relevant opening. A method in accordance with one implementation of the present invention can involve closing a PFO opening with a closure device. In one implementation, this method can involve deploying a left atrial anchor of a closure device about the septum secundum and the primum secundum in the left atrium of the heart. A right atrial anchor of the closure device can be selectively deployed about the septum secundum and the primum secundum in the right atrium of the heart. Placement of the right atrial anchor can be varied through use of a detachable member that can open or close the right atrial anchor. This allows control of a distal hub of the right atrial anchor. In addition, a device for closing internal tissues in accordance with at least one implementation of the present invention can include a left anchor having three or more left anchor members extending from one or more left anchor hubs. The closure device also can include a right anchor connected to the left anchor, the right anchor having three or more right anchor members extending from two or more right anchor hubs. In addition, the closure device can include a stem that is detachably coupled to one of the one or more right anchor hubs. The stem can be used to guide the left and right anchors into an appropriate position, and in some cases, to be at least partially detached in order to view the position of the closure device at the tissue opening. In one implementation, the closure device also includes materials designed to initiate or encourage tissue growth about the area. As such, the closure device can be configured to be delivered and deployed about a tissue opening, such as a PFO opening, in a manner that closes the tissue opening in an efficient manner. Additional features and advantages of exemplary implementations of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by the practice of such exemplary implementations. BRIEF DESCRIPTION OF THE DRAWINGS In order to describe the manner in which the above-recited and other advantages and features of the invention can be obtained, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings. Understanding that these drawings depict only typical embodiments of the invention and are not therefore to be considered to be limiting of its scope, the invention will be described and explained with additional specificity and detail through the use of the accompanying drawings in which: FIG. 1A is a cross-sectional view of a heart; FIG. 1B is an enlarged cross-section view of septum primum and the septum secundum and a PFO tunnel between the septum primum and the septum secundum; FIG. 1C is a perspective view of the septum secundum with the tunnel and the septum primum shown in phantom; FIG. 2 is a plan view of an embodiment of a PFO closure device 100; FIG. 3A is an exploded perspective view of PFO closure device 100 and components of a delivery apparatus 200; FIG. 3B is an assembled side view of PFO closure device 100 and components of delivery apparatus 200 shown in FIG. 3A; FIG. 4A is a perspective view of PFO closure device 100 while still attached via a threaded detachment tip 210 (not shown in FIG. 4A) to a stem 220; Stem 220 and threaded detachment tip 210 comprises a left atrial anchor (LAA) advancer 230; FIG. 4B is a cross-sectional view taken at cutting line 4B-4B which shows retainers 140 within anchor connector 150 and threaded detachment tip 210 (not shown in FIG. 4A) while it is still within anchor connector 150 for delivery; FIG. 4C is a side view of right atrial anchor 170 attached to pivot collar 190 before pivot collar 190 has been pushed fully onto anchor connector 150 and off of stem 220; FIG. 4D is a top view of right atrial anchor 170 attached to pivot collar 190 before pivot collar 190 has been pushed fully onto anchor connector 150 and off of stem 220; FIG. 4E is a cross-sectional view of right atrial anchor 170 attached to pivot collar 190 taken on cutting line 4E-4E. FIG. 4E also provides a perspective view of stem 220 as pivot collar 190 is positioned around stem 220 in a configuration which permits pivot collar 190 to be glided on stem 220; FIG. 4F is an enlarged perspective view of pivot collar 190; FIG. 4G is a bottom view of pivot collar 190 taken from line 4G-4G; FIG. 5A is a perspective view of catheter 250 and a cross-sectional view of PFO 50 which depicts an initial step in the method of delivering PFO closure device 100. FIGS. 5B-5P depict subsequent steps; FIG. 5B is a cross-sectional view of delivery apparatus 200 positioned at PFO 50 to deploy left atrial anchor 130 of closure device 100; FIG. 5C is perspective view of left atrial anchor 130 as it is being deployed out of catheter 250; FIG. 5D is a cross-sectional view of left atrial anchor 130 of closure device 100 deployed into left atrium 40; FIG. 5E is perspective view from within left atrium 40 of left atrial anchor 130 of closure device 100 after it has been deployed into left atrium 40; FIG. 5F is a cross-sectional view of left atrial anchor 130 of closure device 100 being pulled against septum primum 52 and septum secundum 54 in the left atrium 40; FIG. 5G is perspective view from within left atrium 140 of left atrial anchor 130 of closure device 100 being pulled against septum primum 52 and septum secundum 54 in the left atrium 40; FIG. 5H is a cross-sectional view of right atrial anchor 170 of closure device 100 being deployed in right atrium 30; FIG. 5I is perspective view from within right atrium 30 of right atrial anchor 170 after deployment and ready for clockwise rotation by right atrial anchor (RAA) advancer 270; FIG. 5J is a cross-sectional view of right atrial anchor 170 of closure device 100 being deployed in right atrium 30; FIG. 5K is perspective view from within right atrium 30 of right atrial anchor 170 positioned under the overhang of septum secundum 54; FIG. 5L is a cross-sectional view of right atrial anchor 170 being advanced on anchor connector 150 toward left atrial anchor 130; FIG. 5M is perspective view from within right atrium 30 of right atrial anchor 170 as positioned on anchor connector 150 by right atrial anchor (RAA) advancer 270; FIG. 5N is a cross-sectional view of closure device 100 and delivery apparatus 200 after removal of left atrial anchor (LAA) advancer 230; FIG. 50 is perspective view from within right atrium 30 of closure device 100 and right atrial anchor (RAA) advancer 270 of delivery apparatus 200 after removal of left atrial anchor (LAA) advancer 230; FIG. 5N is a cross-sectional view of closure device 100 and delivery apparatus 200 after removal of right atrial anchor (LAA) advancer 270 and catheter 250; FIG. 5P is perspective view from within right atrium 30 of closure device 100 positioned in PFO 50 after removal of delivery apparatus 200; FIG. 6A is a plan view of an embodiment of a PFO closure device 100′; FIG. 6B is an assembled side view of PFO closure device 100′ and components of delivery apparatus 200′; FIG. 6C is an exploded perspective view of right atrial anchor 170′ and right atrial anchor (RAA) retainer 190′, also referred to herein as a pivot collar 190′; FIG. 6D is a cross-sectional view taken along cutting line 6D-6D which depicts pivot collar 190′ as positioned in right atrial anchor 170′; FIG. 6E is a perspective view of closure device 100′ (with right atrial anchor 170′ shown in a cross-sectional view) and components of delivery apparatus 200 including coupler 290′; FIG. 6F is a perspective view of closure device 100′ (with right atrial anchor 170′ shown in a cross-sectional view) and coupler 290′ engaging pivot members 194′ of pivot collar 190′; FIG. 6G is a cross-sectional view taken along cutting line 6G-6G which depicts coupler 290′ engaging pivot members 194′ of pivot collar 190′; FIG. 7A is a perspective view depicting another embodiment of a right atrial anchor at 170 a; FIG. 7B is a perspective view depicting another embodiment of a right atrial anchor at 170 b; FIG. 7C is a perspective view depicting another embodiment of a right atrial anchor at 170 c; FIG. 7D is a plan view depicting another embodiment of a right atrial anchor at 170 d; FIG. 7E is a side view of the embodiment of right atrial anchor 170 d shown in FIG. 7E; FIG. 8A is perspective view from within right atrium 30 of closure device 100 positioned in PFO 50 with both ends of right atrial anchor 170 positioned within pockets 59 a and 59 p; FIG. 8B is perspective view from within right atrium 30 of closure device 100 positioned in PFO 50 with one end of right atrial anchor 170 positioned within pocket 59 p; FIG. 8C is perspective view from within right atrium 30 of closure device 100 positioned in PFO 50 with both ends 171 of right atrial anchor 170 a positioned within pockets 59 a and 59 p; FIG. 8D is perspective view from within right atrium 30 of closure device 100 positioned in PFO 50 with one end 171 of right atrial anchor 170 a positioned within pocket 59 p; FIG. 9 is plan and cross-sectional view of another embodiment of a left atrial anchor as identified at 130′; FIG. 10 is perspective view of another embodiment of a left atrial anchor as identified at 130″; FIG. 11 is cross-sectional view of another embodiment of a left atrial anchor as identified at 130′″; FIG. 12A is a cross-sectional view of another embodiment of a closure device 100 a having a left atrial anchor 130 a and another embodiment of a delivery apparatus 200″ having a left atrial anchor (LAA) advancer 230″; FIG. 12B provides a perspective view of left atrial anchor 130 a as depicted in FIG. 12A during deployment and a cross-section view of catheter 250″ to show right atrial anchor (LAA) advancer 270″; FIG. 12C provides a perspective view of left atrial anchor 130 a as compressed in a left atrium and right atrial anchor 170″ as positioned in the right atrium by right atrial anchor (LAA) advancer 270″; FIG. 13A is a plan view of left atrial anchor 130 a shown in FIGS. 12A-12C; FIG. 13B is a plan view of another embodiment of a left atrial anchor as identified at 130 b; FIG. 13C is a plan view of another embodiment of a left atrial anchor as identified at 130 c; FIG. 13D is a plan view of another embodiment of a left atrial anchor as identified at 130 d; FIG. 13E is a plan view of another embodiment of a left atrial anchor as identified at 130 e; FIG. 13F is a plan view of another embodiment of a left atrial anchor as identified at 130 f as combined with links 122 f; FIG. 14A is an enlarged cross-sectional view of the joint identified at 135 a; FIG. 14B is an enlarged cross-sectional view of the joint identified at 135 b; FIG. 14C is an enlarged cross-sectional view of the joint identified at 135 c; FIG. 14D is a side view of left atrial anchor 130 d; FIG. 15A is a plan view of web 122 for combination with left anchor members of left atrial anchor 130 e; FIG. 15B is a plan view of web 122′ for combination with left anchor members of left atrial anchor 130 e; FIG. 15C is a side view of left atrial anchor 130 f and anchor connector 150 f; FIG. 16A provides a perspective view of a closure device in which a right atrial anchor is configured with three or more right anchor members; FIG. 16B illustrates a close up perspective view of the right atrial anchor illustrated in FIG. 16A; FIG. 16C illustrates an exploded view of corresponding central hubs of the right atrial anchor illustrated in FIGS. 16A and 16B; FIG. 16D provides a perspective view of the closure device shown in FIG. 16A, except showing an alternative implementation of a right atrial anchor; FIG. 16E illustrates a close up perspective view of the right atrial anchor illustrated in FIG. 16D; FIG. 17A illustrates one configuration of a top and bottom central hub that can be used as components of the right atrial anchor show in FIGS. 16A through 16D; FIG. 17B illustrates another configuration of the top and bottom central hub shown in FIG. 17A; FIG. 17C illustrates still another configuration of the top and bottom central hub shown in FIGS. 17A through 17B; FIG. 17D illustrates a further configuration of the top and bottom central hub shown in FIGS. 17A through 17C; FIG. 17E illustrates still another configuration of the top and bottom central hub shown in FIGS. 17A through 17D; FIG. 18A illustrates a perspective view of a closure device configured for partial separation from a stem exiting a catheter in accordance with an implementation of the present invention; FIG. 18B illustrates a perspective view of the closure device shown in FIG. 18A, in which the closure device is partially detached from the stem, but still connected to a flexible filament; FIG. 18C illustrates a perspective view of the closure device shown in FIGS. 18A through 18B, in which the closure device has been completely detached from the stem and flexible filament; FIG. 19 illustrates a perspective view of another embodiment of a closure device in which the right anchor includes three or more anchor members; FIG. 20A illustrates a perspective view of the closure device depicted in FIG. 19 in which the right anchor is positioned about the septum secundum in one position; and FIG. 20B illustrates another perspective view of the closure device depicted in FIG. 20A in which the right anchor is positioned about the septum secundum in a second position. INDEX OF ELEMENTS IDENTIFIED IN THE DRAWINGS Elements of the heart 10 are shown in FIGS. 1A-1C. Some of these elements are also shown in one or more of, or are discussed with, reference FIGS. 5A-5Q, 8A-8D, and 11. These elements include: 15 superior vena cava 25 inferior vena cava 30 right atrium 35 tricuspid valve 40 left atrium 45 bicuspid valve 50 PFO 52 septum primum 53 superior aspect 54 septum secundum 56 a anterior merger point 56 p posterior merger point 57 a anterior portion 57 p posterior portion 58 tunnel 59 a anterior pocket 59 p posterior pocket 60 right ventricle 70 interventricular septum 75 pulmonary veins 80 left ventricle 85 aorta 99 delivery path The elements listed below are components of patent foramen ovale (PFO) closure device e 100 or other embodiments including 100′, 100″, 100′″ and 100 a. Note that all features or subcomponents of components even those which relate only to a particular embodiment are listed below without reference to the particular embodiment. For example, left atrial anchors 130 a-f and right atrial anchors 170′ and 170 a-d include certain features and subcomponents which are unique to the particular embodiment, however, they are generically included in this list and are not individually listed. The following elements are shown in one or more of or are discussed with reference to FIGS. 2, 3A-3B, 4A-4G, 5B-5Q, 6A-6G, 7A-7C, 8A-8D, 9, 10, 11, 12A-12C, 13A-13F, 14A-14D, and 15A-15C. These elements include: 120 mesh 122 web 123 arm link 124 perimeter link 125 inset link 130 left atrial anchor 132 anchor member 133 flex point 134 tips 135 joints (referenced to LAA 130 a-c) 138 first center feature (referenced to LAA 130 a and LAA 130 d) 139 second center feature (referenced to LAA 130 a and LAA 130 d) 140 left atrial anchor retainer 150 anchor connector 151 threads 152 stop 153 end (referenced to anchor connector 150 a) 155 retention holes 157 right atrial anchor (RAA) end of anchor connector 150 158 coating 162 non-resorbable components (referenced to RAA 170 b-c) 164 resorbable components (referenced to RAA 170 b-c) 166 notches (referenced to RAA 170 b-c) 168 torque groove 170 right atrial anchor 171 a anterior end of right atrial anchor 170 171 p posterior end of right atrial anchor 170 172 a stem groove of anterior end 171 a 172 p stem groove of posterior end 171 p 173 a stem chamber of anterior end 171 a 173 p stem chamber of posterior end 171 p 174 hole 175 top surface or contact surface 176 a flat portion 176 p rounded portion 177 concave portion 178 pivot groove 179 pivot chamber 180 loop or flex point or region 184 opening in right atrial anchor 190 right atrial anchor (RAA) retainer, pivot collar or locking arm 191 groove 192 band (referenced with pivot collar 190′) 194 pivot members 195 ferrule (referenced with pivot collar 190′) 196 body portion 199 retention pawls The elements listed below are components of delivery apparatus 200, 200′, 200″ or embodiments. The following elements are shown in one or more of or discussed with reference to FIGS. 3A-3B, 4A, 4E, 5A-50, 6B, 6E-6G, and 12A including: 210 threaded detachment tip 212 threads 220 stem 230 left atrial anchor (LAA) advancer 250 catheter 270 right atrial anchor (RAA) advancer 280 stem 290 coupler 294 torque feature The elements listed below are components of closure device 300, or other embodiments, and which are discussed primarily with reference to FIGS. 16A through 18C including: 300 a-b closure device 302 growth stimulating fiber 304 left anchor 305 a-d left anchor members 306 anchor connector 307 a-c right anchor members 308 a-b right anchor 310 a-e alternate lower central hubs of the right anchor 311 a-c lower central hub extensions 312 catheter 314 a-e alternate top central hubs of the right anchor 315 a-c top central hub extensions 316 threaded stem 320 threaded flexible filament 322 threaded top hub of the right anchor 324 threaded lower hub of the right anchor 330 a-c right anchor members (top hub) 332 a-c right anchor members (lower hub) 334 connector filament 340 lower central hub 342 top central hub DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention extends to systems, methods, and apparatus that can close an internal tissue opening, which should otherwise be closed for proper functioning, and to stimulate tissue growth about the relevant opening. FIGS. 1A-1C depict various views of a heart. Heart 10 is, shown in a cross-section view in FIG. 1A. In a normal heart, the right atrium 30 receives systemic venous blood from the superior vena cava 15 and the inferior vena cava 25 and then delivers the blood via the tricuspid valve 35 to the right ventricle 60. However, in heart 10, there is a septal defect between right atrium 30 and left atrium 40 of a patient's heart which is referred to as a patent foramen ovale (�PFO�). The PFO, which is an open flap on the septum between the heart's right and left atria, is generally identified at 50. In a normal heart, left atrium 40 receives oxygenated blood from the lungs 40 via pulmonary veins 75 and then delivers the blood to the left ventricle 80 via the bicuspid valve 45. However, in heart 10 some systemic venous blood also passes from right atrium 30 through PFO 50, mixes with the oxygenated blood in left atrium 40 and then is routed to the body from left ventricle 80 via aorta 85. During fetal development of the heart, the interventricular septum 70 divides right ventricle 60 and left ventricle 80. In contrast, the atrium is only partially partitioned into right and left chambers during normal fetal development as there is a foramen ovale. When the septum primum 52 incompletely fuses with the septum secundum 54 of the atrial wall, the result is a PFO, such as the PFO 50 shown in FIGS. 1A-1C, or an atrial septal defect referred to as an ASD. FIG. 1C provides a view of the crescent-shaped, overhanging configuration of the typical septum secundum 54 from within right atrium 30. Septum secundum 54 is defined by its inferior aspect 55, corresponding with the solid line in FIG. 1C, and its superior aspect 53, which is its attachment location to septum primum 52 as represented by the phantom line. Septum secundum 54 and septum primum 52 blend together at the ends of septum secundum 54; these anterior and posterior ends are referred to herein as �merger points� and are respectively identified at 56 a and 56 p. The length of the overhang of septum secundum 54, the distance between superior aspect 53 and inferior aspect 55, increases towards the center portion of the septum secundum as shown. A tunnel 58 is defined by portions of septum primum 52 and septum secundum 54 between the merger points 56 a and 56 p which have failed to fuse. The tunnel is often at the apex of the septum secundum as shown. When viewed within right atrium 30, the portion of septum secundum 54 to the left of tunnel 58, which is referred to herein as the posterior portion 57 p of the septum secundum, is longer than the portion of the septum secundum 54 to the right of tunnel 58, which is referred to herein as the anterior portion 57 a of the septum secundum. In addition to being typically longer, the left portion also typically has a more gradual taper than the right portion, as shown. The area defined by the overhang of the anterior portion 57 a of septum secundum 54 and the septum primum 52 and extending from the anterior merger point 56 a toward tunnel 58 is an anterior pocket 59 a. Similarly, the area defined by the overhang of the posterior portion 57 p of septum secundum 54 and the septum primum 52 and extending from the posterior merger point 56 p toward tunnel 58 is a posterior pocket 59 p. The invention described hereinafter relates to a closure device, a delivery apparatus, methods, and systems for closure of a PFO. FIG. 2 depicts one embodiment of a closure device at 100. FIGS. 3A-3B depict closure device 100 and an embodiment of a delivery apparatus 200. Closure device 100 comprises a left atrial anchor 130 (or �left anchor�) and a right atrial anchor 170 (or �right anchor�). By way of explanation, the closure device 100 disclosed herein can be used for any internal tissue, although frequent reference is made herein to closing a PFO opening of a heart tissue using right atrial anchors and left atrial anchors for purposes of simplicity. Nevertheless, in the embodiment of the closure device shown in FIG. 2, left atrial anchor 130 and right atrial anchor 170 are coupled together via an anchor connector 150. Left atrial anchor 130 is secured to anchor connector 150 via two left atrial anchor (LAA) retainers 140. While the components described above are separate, several of these components may alternatively be integral. For example, in another embodiment, left atrial anchor 130, retainer 140 and/or anchor coupler 150 may be integral. Right atrial anchor 170 is secured to anchor connector 150 by a right atrial anchor (RAA) retainer. The embodiment of right atrial anchor (RAA) retainer identified at 190 is referred to herein as a pivot collar. Anchor connector may alternatively be coated with a coating 158 as may left atrial anchor 130, right atrial anchor 170 and any other component of closure device 100 to facilitate closure of PFO 50. Such coatings may be applied to promote occlusion of tunnel 58 and endothelial growth while minimizing thrombosis and embolization. For example, a coating of bioresorbable polymers may be applied which facilitates closure of tunnel 58. Examples of suitable bioresorbable polymers include polycaprolactones, polyorthoesters, polylactide, polyglycolide and copolymers of these polymers. An example of a suitable copolymer is polylactide and polyglycolide. In addition to polymers, drug eluting compositions, proteins and growth factors may also be applied as coatings. Examples of suitable proteins and growth factors include elastin, fibronectin, collagen, laminin, basic fibroblast growth factor, platelet-derived growth factor. The coating may be cellular or foamed or may be more dense as needed. The material used for the coating may depend on the particular component of closure device 100 being coated. For example, elastin is useful for coating left atrial anchor 130 and right atrial anchors as it is, not aggressive for tissue growth. Anchor connector 150 may be wrapped with a foam material, fuzzy bioresorbable thread or any other material which assists in facilitating the closure of tunnel 58. By coating components of closure device 100 such as left atrial anchor 130, anchor connector 150 and right atrial connector 170, tissue growth can be promoted at the points of contact of each of these three components in three regions or planes. Note that the components of the closure device may also be formed entirely from the materials listed above for coatings. FIG. 3A provides an exploded perspective view of closure device 100 and some components of delivery apparatus 200. FIG. 3B provides a cross-sectional view of the same components. Components of delivery apparatus 200 shown in FIGS. 3A-3B include a left atrial anchor (LAA) advancer 230 for advancing left atrial anchor 130, a right atrial anchor (RAA) advancer 270 for advancing right atrial anchor 170 and catheter 250. Left atrial anchor (LAA) advancer 230 comprises a stem 220 which is fixedly or integrally coupled to a threaded detachment tip 210. Right atrial anchor (RAA) advancer 270 comprises a stem 280 and a coupler 290. Left atrial anchor (LAA) advancer 230 pass through right atrial anchor (RAA) advancer 270. FIGS. 4A-4G show additional features of closure device 100 particularly, right atrial anchor 170. The functions of these features are best understood with reference to FIGS. 5A-5P. FIG. 4A provides a perspective view of closure device 100 with anchor connector 150 still attached to stem 220 of left atrial anchor (LAA) advancer 230. Right atrial anchor 170 has not yet been advanced into its final position on the right atrial anchor (RAA) end 157 of anchor connector 150. Hole 155 in end 157 of anchor connector 150 are shown in FIG. 4A ready to receive retention pawls 199 of pivot collar 190, which is more generally referred to as a right atrial anchor (RAA) retainer. FIG. 4B provides a cross-section view of anchor connector 150 taken at cutting line 4B-4B. FIG. 4B shows retainers 140 within anchor connector 150 and a coating 158 on anchor connector 150. FIG. 4C is a side view of right atrial anchor 170 attached to pivot collar 190 before pivot collar 190 has been pushed fully onto anchor connector 150 and off of stem 220. FIG. 4D is a top view of right atrial anchor 170 attached to pivot collar 190 in the same position as is shown in FIG. 4C. FIG. 4E provides a cross-sectional view of right atrial anchor 170 taken on cutting line 4E-4E, right atrial anchor 170 is in the same position as FIGS. 4C-4D on stem 220 after being rotated. FIG. 4E also provides a perspective view of stem 220 as pivot collar 190 is positioned around stem 220 in a configuration which permits pivot collar 190 to be glided on stem 220. Right atrial anchor 170 has two opposing ends which are respectively adapted to be positioned in anterior pocket 59 a and posterior pocket 59 p. The opposing end identified at 171 a may be placed in anterior pocket 59 a or adjacent to the anterior portion 57 a of septum secundum 54. Similarly, the opposing end of right atrial anchor 170 identified at 171 p may be placed in posterior pocket 59 p or adjacent to the posterior anterior portion 57 p. Right atrial anchor is relatively symmetrical so that end 171 p or end 171 a can be positioned in either posterior pocket 59 p or anterior pocket 59 a. Accordingly, the use of the designations �a� and �p� to designate an eventual position with either an anterior or posterior orientation does not indicate that either end 171 a or end 171 p must be positioned to have respective anterior and posterior orientations. To permit right atrial anchor 170 to be easily moved within a catheter, right atrial anchor 170 has three chambers which are adapted to fit around pivot collar 190, anchor connector 150 and stem 220. A stem groove is formed in the two opposing ends of right atrial anchor 170 as identified at 172 a and 172 p which each respectively defined a stem chamber 173 a and 173 p. Pivot collar 190 has pivot members 194 which are received within holes 174 to permit right atrial anchor to pivot with respect to pivot collar 190. Right atrial anchor 170 has a pivot groove 178 which defines a pivot chamber 179. In this embodiment, the chambers described above allow relatively concentric movement of right atrial anchor 170 with respect to catheter 250 shown in FIG. 5B, anchor connector 150 and stem 220. Right atrial anchor 170 has a top surface 175 which has a convex shape. The convex shape of top surface 175 permits optimal anatomical conformance with the shape of septum secundum 54. Note that the shape of surface 175 on either side of pivot groove 178 is essentially the same to permit right atrial anchor to oriented with ends 171 a and 171 p respectively positioned adjacent to portions 57 p and 57 a or vice versa. Right atrial anchor has a flat portion 176 a opposite a rounded portion 176 p at its bottom surface. Flat portion 176 a provides for an optimal fit within catheter 250. The bottom surface includes a concave portion 177 between flat portion 176 a and rounded portion 176 p. Concave portion 177 is shaped to minimize the size of right atrial anchor 170. Right atrial anchor 170 has a torque groove 168 which is adapted to fit in a mated with a complimentary torque feature 194. The interaction of torque groove 168 and torque feature 194 to rotate and move right atrial anchor 170 is described below with reference to FIGS. 51-50. Another embodiment of a torque feature for rotation and movement of a right atrial anchor is described below with reference to FIGS. 6A-6G. Details of pivot collar 190 can be easily seen in the enlarged cross-sectional view of FIG. 4F and the view of pivot collar provided by FIG. 4G which is taken along line 4G-4G. Note that another embodiment of a right atrial anchor (RAA) retainer identified at 190′ is discussed below in relation to FIG. 6C. As mentioned above, pivot collar 190 has pivot members 194 which are received within holes 174 to permit right atrial anchor to pivot with respect to pivot collar 190. Pivot members 194 extend from body portion 196. A plurality of arms 198 extend from body portion 196. Each arm 198 has a retention pawl 199. As mentioned above, retention pawls 199 enter retention hole 155 of anchor connector 150 to secure pivot collar 190 to anchor connector 150. FIGS. 5A-5P depict one method for delivering closure device 100 to PFO 50 via delivery apparatus 200 and deploying closure device 100. Steps involved in recapturing closure device 100 are shown in FIGS. 6A-6G. Catheter 250 is introduced to PFO 50 via delivery path 99 which is identified in FIGS. 1A-1C. Catheter 250 is a long somewhat flexible catheter or sheath introduced into a vein such as the femoral vein and routed up to the right atrium of a patient's heart. The catheter may be tracked over a guide wire that has been advanced into the heart by a known methodology. After catheter 250 is introduced into the heart via inferior vena cava 25, catheter 250 is positioned at right atrium 30 in front of the interatrial communication or PFO, and then through tunnel 58. Once the distal end of 252 of catheter 250 is positioned at the end of tunnel 58 as shown in FIGS. 5A-5B or extends beyond tunnel 58, left atrial anchor 130 is deployed as shown in FIG. 5D. FIG. 5B provides a cross-sectional view of closure device 100 and delivery apparatus 200 just before left atrial anchor 130 is pushed out of catheter 250 and deployed into left atrium 40. As indicated above, left atrial anchor (LAA) advancer 230, more particularly stem 220 and threaded detachment tip 210, move within right atrial anchor (RAA) advancer 270, more particularly stem 280 and coupler 290, to advance left atrial anchor 130 within catheter 250. FIG. 5C depicts left atrial anchor 130 just before deployment and FIG. 5D depicts left atrial anchor 130 after deployment. As provided below, the left atrial anchor may have many different configurations which permit it to fit within the catheter, either by being rotatably or pivotally aligned with the axis of the catheter or by being sufficiently flexible to fit within the catheter in a compressed and/or flexed state. The state in which a left atrial anchor is within the catheter will be referred to herein as a delivery configuration. The state in which an anchor is outside of the catheter and has been pivoted, rotated, flexed, expanded, or otherwise put in position to be placed at the PFO site will be referred to herein as a deployed configuration. Depending on the particular embodiment of left atrial anchor, in deploying the left atrial anchor from the catheter, it will be expanded, pivoted, or rotated to extend once out of the catheter. The embodiment of the left atrial anchor depicted in FIG. 5D expands and pivots from the delivery configuration to a deployed configuration. Left atrial anchor 130 may be formed from any suitable material such as coiled metal, coiled polymer or a solid core of metal or plastic wrapped with metal or polymer coil. For example, left atrial anchor may be formed from super elastic nickel/titanium or nitinol. It may have a single strand core or a core with multiple strands. The core may be wrapped with metal wire formed from a dense biocompatible metal such as platinum, platinum/tungsten alloy, platinum/iridium alloy, or platinum/iridium/rhodium alloy to increase the radio-opacity of the left atrial anchor. Utilizing a multiple strand core permits the left atrial anchor to have lower bending stiffness and better memory compared with a left atrial anchor formed with a single strand having approximately the same cross-sectional area as the multiple strands. FIG. 5E shows the appearance of left atrial anchor 130 from within left atrium 40 once left atrial anchor 130 has been deployed. Catheter 250 is shown extending beyond tunnel 58. FIGS. 5F-5G show left atrial anchor being pulled proximally and positioned proximate to the PFO. For embodiments such as left atrial anchor 130, the left atrial anchor pivots at or near its center. This pivoting motion permits the left atrial anchor to conform to the surfaces of the septum secundum and the septum primum. Once left atrial anchor 130 is pivoted at an angle with respect to the axis of the anchor connector 150, left atrial anchor 130 is pulled flush against septum secundum 54 and septum primum 52. As explained above, each anchor member 132 is angled. More particularly, each anchor member 132 is bowed such that there is a flex point 133 along its length. Pulling left atrial anchor 130 flush against septum secundum 54 and septum primum 52 flattens anchor members 132 of left atrial anchor 130 and enables left atrial anchor 130 to push against septum secundum 54 and septum primum 52 when closure device 100 is finally positioned. Note that tips 134 of each anchor member 132 remain angled slightly away from septum secundum 54 and septum primum 52 even after anchor members 132 are flattened to minimize trauma to septum secundum 54 and septum primum 52. FIG. 5G depicts left atrial anchor 130 with two anchor members 132 of the left atrial anchor positioned against the septum primum of the heart and the other two anchor members 132 positioned against the septum secundum of the heart. In addition to a left atrial anchor with four anchor members, other configurations permit at least one anchor member 132 to be positioned against the septum primum of the heart while at least one other anchor member is positioned against the septum secundum of the heart such that the left atrial anchor remains positioned in the left atrium. For example, the left atrial anchor may have two or three anchor members or more than four anchor members. Examples of other shapes are described below in reference to FIGS. 9-11, 12A-12C, 13A-13I and 14A-14D. Right atrial anchor 170 can be seen in its delivery configuration rotated within catheter 250 in FIG. 5F. Right atrial anchor 170 is deployed by advancing it with respect to catheter 250 by urging right atrial anchor (RAA) advancer 270 against right atrial anchor 170. Once outside of catheter 250 as shown in FIG. 5H, right atrial anchor 170 pivots into a deployed configuration such that it extends perpendicular to, or at least at an angle with respect to catheter 250. Note that at least one anchor member 132 is in a different plane relative to another anchor member 132. FIG. 5I shows right atrial anchor 170 being rotated clockwise. Rotation of right atrial anchor 170 is achieved by rotating stem 280 of right atrial anchor (LAA) advancer 270. Left atrial anchor 130 and right atrial anchor 170 are not brought into a locked configuration until after right atrial anchor 170 is positioned. As right atrial anchor 170 is rotated, posterior end 171 p tucks under the overhang of posterior portion 57 p of septum secundum 54 and in posterior pocket 59 p. The posterior end of a typical septum secundum has a deeper pocket than the anterior portion of a typical septum secundum. The deeper pocket of the typical posterior end makes it easier to position an end of the right atrial anchor than under the anterior portion. Note that while FIGS. 5J-5Q depict or are described in reference to placement of the ends of right atrial anchor 170 into pocket 59 a and pocket 59 p at the anterior and posterior portions, closure device 100 also effectively closes a PFO when only one end of right atrial anchor 170 is positioned within pocket 59 p and the other end is positioned on top of anterior portion 57 a instead of in pocket 59 a as discussed below with reference to FIG. 8B and FIG. 8D. FIG. 5J depicts right atrial anchor positioned with its top surface 175 directed toward tunnel 58. FIG. 5K shows right atrial anchor 170 with its posterior end 171 p partially under the overhanging posterior portion 57 p of septum secundum in posterior pocket 59 p and its anterior end 171 a partially under the overhanging anterior portion 57 a of septum secundum 54 in anterior pocket 59 a. In FIG. 5L, right atrial anchor 170 is shown after being driven toward left atrial anchor 130 on anchor connector 150 by right atrial anchor (RAA) advancer 270. Advancement of right atrial anchor 170 on anchor connector 150 enables retention pawls 199 of right atrial anchor (RAA) retainer 190 to enter retention hole 155 of anchor connector 150 so that right atrial anchor (RAA) retainer 190 is secured to anchor connector 150. Once retainer 190 locks with connector 150, right atrial anchor 170 becomes positioned further under septum secundum 54, as shown in FIG. 5M. More particularly, FIG. 5M shows right atrial anchor 170 with its posterior end 171 p fully under the overhanging posterior portion 171 p of septum secundum 54 in posterior pocket 59 p and its anterior end 171 a fully under the overhanging anterior portion 57 a of septum secundum 54 in anterior pocket 59 a. With reference to FIG. 3A and FIG. 4A, note that there may be only one hole 155 while there is a plurality of retention pawls 199. This ratio and the relative widths of the hole 155 and retention pawls 199 ensures that at least one pawl 199 will be engaged in hole 155. The sequence of steps described above with reference to FIGS. 5H-5M, indicates that the right atrial anchor 170 is first rotated clockwise into position and then right atrial anchor 170 is advanced toward left atrial anchor 130. However, these steps may also be achieved in manner which involves simultaneous clockwise rotation and advancement of right atrial anchor 170. Simultaneous rotation and advancement may involve a transition from a combination of rotation and advancement to just advancement. FIGS. 5N-5O shows catheter 250 after removal of left atrial anchor (LAA) advancer 230. Left atrial anchor (LAA) advancer 230 can be removed after right atrial anchor 170 has been driven forward and locked with anchor connector 150 as described with reference to FIG. 5H-5M. Removal of left atrial anchor (LAA) advancer 230 is achieved by rotating stem 220 counterclockwise while maintaining tension on stem 220 and holding stem 280 secure so that threads 212 of tip 210 are no longer engaged by threads 151 of anchor connector 150. Once right atrial anchor 170 and left atrial anchor 130 have been deployed and properly positioned in the heart against the septum primum and septum secundum, as discussed above, the deployed anchors may then be detached from the remainder of the device. More particularly, after left atrial anchor (LAA) advancer 230 has been removed, then right atrial anchor advancer 270 is removed from catheter 250. FIG. 5P-5Q depict closure device 100 in a closure position relative to PFO 50 after delivery apparatus 200 has been removed. Following deployment and positioning of the anchors, the right and left atrial anchors are left to remain in the heart on opposite sides of the PFO. The tissue at the PFO is compressed between left atrial anchor 130 and right atrial anchor 170 via anchor connector. This configuration permits closure device 100 to remain in the heart in a stable configuration and facilitate closure of the PFO. FIGS. 6A-6F depict another embodiment of closure device which is identified as 100′ and another embodiment of delivery apparatus which is identified as 200′. The components of closure device 100′ which are different from closure device 100 include anchor connector 150′, right atrial anchor 170, and right atrial anchor (RAA) retainer 190′. The component of delivery apparatus 200′ which is different from delivery apparatus 200 includes coupler 290′ of right atrial anchor (RAA) advancer 270′. As explained below, closure device 100′ and delivery apparatus 200′ permit adjustments based on the length of the particular PFO tunnel and also permit recapture of closure device 100′ by delivery apparatus 200′. FIGS. 6A-6B shows anchor connector 150′ having three retention holes which are identified at 155 a-c. A plurality of retention holes enables retention pawls 199 of right atrial anchor (RAA) retainer 190′ to enter holes 155 a-c of anchor connector 150′ until right atrial anchor 170′ is set in a desired position. As the retention pawls 199′ are moved in succession in holes 155 a-c to bring right atrial anchor 170′ closer to left atrial anchor 130, the operator can identify the position of retention pawls 199′ with respect to each retention holes 155 by either feeling distinct clicks or by using instrumentation to view their position. The ability to variably set the length of the portion of anchor connector 150′ between left atrial anchor 130 and right atrial anchor 170′ is advantageous as tunnels 58 have different lengths. FIG. 6C provides a detailed depiction of pivot collar 190′ which is another example a right atrial anchor (RAA) retainer. Pivot collar 190′ has two bands 192′ which extend around body portion 196′. Bands 192′ each have a ring portion 193′ and opposing pivot members 194′ at opposite ends of the ring portion 193′. Each pivot member 194′ extends through hole 174′ and is held in hole 174′ by ferrule 195′. FIGS. 6D-6G and FIG. 6B show coupler 290′ and its torque feature 294′. FIG. 6D shows the portions of pivot members 194′ engaged by torque features 294′, the portion not in holes 174′ of right atrial anchor 170′. As can be seen in FIG. 6G, the space between ring portions 193′ of pivot collars 190′ and right atrial anchor 170′ is filled by coupler 290′ when torque features 294′ engage pivot members 194′. FIG. 6E shows coupler 290′ approaching pivot collar 190′. FIG. 6F shows coupler 290′ and pivot collar 190′ locked together through the engagement of torque feature 294′ and pivot member 194′. After the anchors have been deployed on either side of the PFO, the position of the anchors may be observed via fluoroscopic, ultrasonic, or any other type of imaging available to one of skill in the art. If the anchors are in an improper or otherwise undesirable position, they may be recaptured and withdrawn or recaptured and redeployed. In the embodiment depicted in FIGS. 6A-6G, the location of the error in deployment or delivery determines where the recapture occurs. For example, if right atrial anchor 170 has been pushed through tunnel 58 and into left atrium 40 then catheter 250 is advanced distally through the PFO opening and into the left atrium so that the anchors may then be recaptured in catheter 250. Tip 210 is rotated clockwise enough turns to push retention pawls 199 out of retention holes 155 of anchor connector 150. The operator then pulls on stem 280′ of right atrial anchor (RAA) advancer 270′ while holding left atrial anchor (LAA) advancer 230. This permits right atrial anchor 170 to be pulled into catheter 250 by utilizing split tip 252 of catheter 250 to pivot right atrial anchor 170 while pulling on stem 280′ of right atrial anchor (RAA) advancer 270′. Note that each of retention pawls 199′ and holes 155 are shaped to enable retention pawls 199′ to remain in place unless lifted by tip 210 for detachment during recapture. More particularly, retention pawls 199 each have a ramp-shaped inner surface and tip 210 lifts retention pawls up so that the ramp-shaped inner surfaces may ride up the edge of holes 155 when right atrial anchor (RAA) advancer 270 is pulled. Catheter 250 recaptures left atrial anchor 130 by pulling left atrial anchor 130 into catheter 250 while split tip 252 is in the left atrium. In contrast to having a distinct stem groove 172 p and pivot groove 178 like right atrial anchor 170, right atrial anchor 170′ has a combined stem and pivot groove 178′. The combined groove 178′ is sized to permit easy access by pivot collar 190. Also, once torque feature 294′ engages pivot members 194′ and the engagement is used to pull right atrial anchor 170′ into catheter 250, space is needed within right atrial anchor 170 so that coupler 290′ can be received. FIGS. 7A-7C depict other embodiments of right atrial anchors respectively at 170 a-c. Like right atrial anchors 170 and 170′, right atrial anchor 170 c has an arched shape. In contrast, right atrial anchors 170 a and 170 b are relatively straight. Right atrial anchors 170 b and 170 c have non-resorbable components 162 b and 162 c and resorbable components 164 b and 164 c. Examples of resorbable components include components formed from bioresorbable polymers and drug-eluting compositions as described above. A bio-resorbable polymer may be used to give bulk to the anchor and further to promote the formation of fibrous tissue. In such embodiments, the non-resorbable components may be used as a backbone. Although not necessary, a metal wire backbone provides for radio-opacity needed for x-ray imaging. Of course, in some embodiments the anchors and other components of the closure device may entirely comprise bio-resorbable material such that no foreign material remains in the heart after a sufficient period of time for closure of the PFO to take place. Examples of non-resorbable components include stainless steel and a super-elastic material such as nitinol. These components, like the left atrial anchor, may have any suitable cross-sectional shape. For example, left atrial anchor and the non-resorbable components of the right atrial anchor may be formed from round or flattened wire that has been formed into an appropriate shape or may be wrought from bulk material as desired. As shown in FIG. 7A, right atrial anchor 170 a has a top surface 175 a and a bottom surface 177 a which are both relatively straight and parallel to each other. Right atrial anchor 170 a has a groove 178 a which is open along its entire length except for its center. As mentioned above and as shown in FIGS. 7B-7C, right atrial anchors 170 b and 170 c, respectively have non-resorbable components 162 b and 162 c and resorbable components 164 b and 164 c. In these embodiments, the resorbable component and the non-resorbable component are attached to each other. The resorbable components are segmented with notches respectively at 166 b and 166 c to provide enhanced flexibility. The notches facilitate flexing of the anchor into the arched configuration against the PFO. FIGS. 7D-7E depicts another embodiment of a right atrial anchor at 170 d. Right atrial anchor 170 d has two opposing anchor members joined together by a loops 180 which act as flex points or regions for ends 171 to be flexed together inside a catheter when right atrial anchor 170 d is in its delivery configuration. Loops 180 each define a hole 174 d. Holes 174 d is adapted to engage pivot members 194 or 194′ of right atrial anchor (RAA) retainer 190. An optional web 120 is shown extending within the area defined by the wire forming the opposing anchor members. Web 120 may also extend beyond the wire. A hole 184 d is provided in web 120 for an anchor connector (not shown in FIGS. 7D-7E) such as anchor connector 150 or 150 a. FIGS. 8A-8D depict two different embodiments of right atrial anchors which are each positioned adjacent to a septum secundum in anatomical conformance with the septum secundum. The right atrial anchor is preferably arched with an arch which is similar to that of the septum secundum. Right atrial anchor 170 has an arched top surface 175 which is similar in shape to superior aspect 53, which is the attachment location of septum secundum 54 to septum primum 52. Right atrial anchor also has a length which permits it to be tucked under the overhang of septum secundum 54. In addition to being rigid and having an arched configuration, the right atrial anchor can also have other shapes such as a straight configuration while being flexible so that it can conform to the arched shape of the superior aspect 53 of the septum secundum. For example, instead of right atrial anchor 170 being formed from a rigid material, it can also be formed from a more flexible material. Similarly, a flexible embodiment such as shown at 170 c may be used. FIG. 8B shows right atrial anchor 170 positioned within pocket 59 p and the other end positioned on top of anterior portion 57 a instead of in pocket 59 a. As described above, relying on the anatomy of the posterior portion 57 p of septum secundum 54 to position at least one end of right atrial anchor is an effective methodology for effectively closing a PFO. The ends of right atrial anchor are both short enough so that whichever end is positioned in pocket 59 p, it conforms with the anatomy of a portion of the septum secundum. As shown in FIGS. 8C-8D, a right atrial anchor which is rigid and straight, such as right atrial anchor 170 a described above with reference to FIG. 7A, may be used. Right atrial anchor 170 a has a posterior end which is short enough to fit within pocket 59 p. Although, the rigidity and straight configuration of right atrial anchor 170 a prevent it from curving like superior aspect 53, top surface 175 a is able to abut superior aspect 53 and septum secundum 54 does not block anchor connector 150 from full access into tunnel 58. The embodiments of the right atrial anchor described above, facilitate closure of the PFO by allowing the right atrial anchor to be tucked under at least a portion of the septum secundum and against the septum primum such that the right atrial anchor can be drawn taughtly against both the septum primum and septum secundum. Healing is thereby facilitated along a greater portion of PFO tunnel 58. At the location of a PFO, the septum primum is joined with the septum secundum at two �merger points,� as discussed above. The right atrial anchor may be shorter than the distance between these merger points to enhance the ability of the right atrial anchor to be positioned with both of its ends within pockets 59 a and 59 p. In other words, the right atrial anchor may extend from the point at which the septum primum is joined with the septum secundum on one end of the PFO �arch� to the point at which the septum primum is joined with the septum secundum on the other end of the PFO arch. Contact with these two merger points facilitates the right atrial anchor remaining in its proper position without being pulled through the PFO opening. Because a typical PFO has an arch that is 12-15 mm long, the right atrial anchor typically has a length of about 10 to about 30 mm although variations above and below this are contemplated in order to accommodate varying PFO anatomies. An example of a suitable right atrial anchor has a length within a range of about 15 mm to about 22 mm. An example of a suitable left atrial anchor has a length of about 15 mm to about 30 mm. FIG. 9 depicts another embodiment of a left atrial anchor identified at 130′ which has three anchor members 132′. Left atrial anchor 130′ also has a web material or mesh 120 positioned on anchor members 132′ to further facilitate closure of PFO 50. Left atrial anchor may have any suitable number of anchor members. For example, the left atrial anchor may have just two opposing anchor members like the right atrial anchor such that both anchor members are essentially rod-shaped. Similarly, the left atrial anchor may be rod-shaped while the right atrial anchor is banana-shaped. Anchors which are rod-shaped or banana-shaped are referred to herein as elongate-shaped anchors. When both anchors have just two opposing anchor members, the right and left atrial anchors are positioned perpendicular to one another at the point of their approximation such that when they are brought together they generally form a plus (+) shape at that point. With respect to such embodiments, the right atrial anchor is typically placed in an approximately horizontal, although arched, position in the right atrium against and with respect to the PFO and the left atrial anchor is typically placed in an approximately vertical position in the left atrium against the PFO. If not configured in perpendicular orientations with respect to one another, the right and left atrial anchors will typically at least be offset from one another. In other words, the right atrial anchor will typically be positioned such that it is at an angle with respect to�i.e., not parallel to�the left atrial anchor such that are positioned in intersecting planes with respect to one another. Also, one or both anchors may have an off-center pivot point. FIG. 10 depicts another embodiment of a closure device at 100″. Closure device 100″ has a right atrial anchor 170″ comprising a single wire looped to have opposing anchor members. Right atrial anchor 170″ is connected to left atrial anchor 130″ via an anchor connector 150″ which is a ring with either an elliptical or round shape. From the view of FIG. 10, only two anchor members of left atrial anchor 130″ are depicted. However, as understood from the juncture of the anchor members, left atrial anchor 130″, in this embodiment, has four anchor members. FIG. 11 depicts another closure device at 100′″. Closure device 100′″ is formed from an integral material. Closure device 100′″ has an anchor connector 150′″ which is integral at one end with a left atrial anchor 130′″ and is integral at the other end with right atrial anchor 170′″. Anchor connector 150′″ is coated with a coating which facilitates closure of PFO 50. Examples of suitable coatings include bioresorbable polymers and drug-eluting compositions. Closure device 100′″ is shaped to enable conformance with the anatomy of septum primum 52, septum secundum 54 and tunnel 58. FIGS. 12A-12C depict another embodiment of a closure device 100 a comprising a left atrial anchor 130 a and a right atrial anchor 170″ which are connected together by an anchor connector 150 a. FIGS. 12A-12C also depict 200″ another embodiment of delivery apparatus 200 having a left atrial anchor (LAA) advancer 230″ and a right atrial anchor (LAA) advancer 270″. Left atrial anchor 130 a has a first set of anchor members 132 a on top of a second set of anchor members 132 a. The two sets are identical. The tips 134 a of anchor members 132 a are joined together at joints 135 a. FIG. 13A provides a plan view of left atrial anchor 130 a and FIG. 14A provides an enlarged cross-sectional view of joint 135 a. Left atrial anchor (LAA) advancer 230″ pushes left atrial anchor 130 a out of catheter 250 and into the left atrium. FIG. 12B provides a perspective view of left atrial anchor 130 a during deployment. Anchor connector 150 a of closure device 100 a is a thread or filament. Anchor connector 150 a is tied to first center feature 138 a of left atrial anchor 130 a at end 153 a. Anchor connector 150 a has a stop 152 a which is passed over by second center feature 139 a of the second set of anchor members 132 a as second center feature 139 a is pushed towards first center feature 138 a. Anchor connector 150 a can be used to selectively expand or collapse left atrial anchor 130 a. FIG. 12C provides a perspective view of left atrial anchor 130 a as compressed in a left atrium and right atrial anchor 170″ as positioned in the right atrium by right atrial anchor (LAA) advancer 270″. Right atrial anchor 170″ has an opening 184 through which anchor connector 150 a passes. Right atrial anchor 170″ also has a right atrial anchor (RAA) retainer 190″ also referred to as a locking arm. Locking arm 190″ permits right atrial anchor 170″ to advance on anchor connector 150 a toward left atrial anchor 130 a. While other embodiments permit right atrial anchor 170″ to be retracted on anchor connector, locking arm 190″ does not permit right atrial anchor 170″ to be moved away from left atrial anchor 130 a. Note that coupler 290″ of right atrial anchor (LAA) advancer 270″ has a torque feature 294″ for engaging torque groove 168 of right atrial anchor 170″. Other configurations of left atrial anchor 130 a having two sets of linked anchor members are shown in FIGS. 13B-13D and are identified as 130 b-130 d. FIGS. 14B-C provide enlarged cross-sectional views of joints 135 b-c. FIG. 14D is a side view of left atrial anchor 130 d being pulled slightly at its center. FIGS. 13E-13F depict additional embodiments of left atrial anchors as identified at 130 e-130 f. Left atrial anchor 130 e depicts an embodiment having six anchor members 132 e. FIG. 15A and FIG. 15B depict embodiments of webs respectively at 122 and 122′. Another embodiment of a web, web 122 f is shown in FIG. 13F and FIG. 15C as used in combination with left atrial anchor 130 e to provide left atrial anchor 130 f. Web 122 f comprises arm links 123 f, a perimeter link 124 f and an inset link 125 f. Perimeter link 124 f comprises link components which are either integral or separate and are attached to each end or tip 134 of each anchor member 132 e. Arm links 123 f and inset link 125 f may also comprise link components which are either integral or separate. Web 122 shown in FIG. 15A differs from web 122 f in that it does not have an inset link. Web 122′ shown in FIG. 15B differs from web 122 f as web 122′ has a plurality of inset links. The inset links extending around a perimeter at certain lengths of each anchor member. FIG. 15C depicts a plan view of left atrial anchor 130 f shown in FIG. 13F with anchor connector 150 f in the center of anchor 130 f. The combination of webbed links on anchor members as shown in FIG. 13F permits left atrial anchors 130 f to have a triangulated configuration as shown in FIG. 15C. The links may be flexible and have some tensile strength but limited compressive strength much like a string. When flexible links are used in combination with arms which are relatively rigid, the combination permits compression within a catheter in a delivery configuration and a deployed configuration which resists collapsing and being pulled into tunnel 58. Triangulation anchors such as anchor 130 f may have various configurations. For example, the links do not need to by symmetrical, integral or linked continuously on the anchor members. The webs may be formed from the same or different materials as the anchor members. For example, the anchor members may be formed from nitinol while the links are formed from resorbable polymers. Webs 122 and mesh 120 shown with reference to FIG. 9 and FIG. 7D may be used with either a left atrial anchor or a right atrial anchor. Materials may also be used as a mesh or links which have a fuzzy appearance. Triangulation atrial anchors are not shown with a web material, however, it should be understood that such an embodiment acts much like an umbrella. Since the embodiments disclosed herein have right and left atrial anchors that are coupled to one another�i.e., they are integral, attached, or otherwise connected with one another�once the anchors have each been deployed, they will remain in place on either side of the PFO opening. Right atrial anchor and left atrial anchor can be coupled together by any available structure or in any available manner. For example, the respective anchors may be considered �coupled� if they are integral, attached, or otherwise connected with one another. The atrial anchor may be shaped to provide a torsion-spring-like flexural pivot that minimizes strain in the anchor material as it is deformed between the delivery configuration and the deployed configuration and vice versa. Note that while anchor connectors 150, 150′ and 150 a are shown as the structure for coupling the right and left atrial anchors, some embodiments of the invention don't have a connector at all. For example, portions of the anchors may extend into or through tunnel 58 to join the anchors together. Also, the anchors could be welded, glued, or integrally connected. Moreover, a variety of other suitable structures or other arrangements could be used to connect the anchors, such as a cable, filament, chain, clip, clamp, band, or any other manner of connection available to those of skill in the art. The left atrial anchors disclosed herein are examples of left atrial anchor means for anchoring a closure device in the left atrium of a heart. The right anchor disclosed herein are examples of right atrial anchor means for anchoring a closure device in the right atrium of a heart. Mesh disclosed herein is an example of means for increasing the surface area of the atrial anchor. Webs disclosed herein are means for preventing an atrial anchor from extending beyond the deployed configuration. The anchor connectors disclosed herein are examples of means for connecting the right atrial anchor means and the left atrial anchor means. Coatings and components of a closure device formed from a bioresorbable polymer, a drug eluting composition, a protein, a growth factor or a combination thereof, etc. are examples of means for enhancing mechanical closure of a PFO. Left atrial anchor retainers disclosed herein are examples of left atrial anchor retainer means for retaining the left atrial anchor on the anchor connector. Right atrial anchor retainers herein are examples of right atrial anchor retainer means for retaining the right atrial anchor on the anchor connector. Left atrial anchor (LAA) advancers disclosed herein are examples of means for controlling the position of the left atrial anchor. Right atrial anchor (LAA) advancers disclosed herein are examples of means for controlling the position of the right atrial anchor. The catheters disclosed herein are examples of means for positioning the closure device. The closure devices disclosed herein are examples of means for closing a PFO. FIG. 16A illustrates another configuration of a closure device in accordance with the present invention, where the closure device includes a right anchor having three or more anchor members. In particular, FIG. 16A illustrates a closure device 300 a that includes a left anchor 304 (also referred to as a �left atrial anchor�) having multiple anchor members 305 a-305 d, an anchor connector/separator 306, and a right anchor 308 a (also referred to herein as a �right atrial anchor�) having at least three (or more) anchor members 307 a-307 c. The three (or more) right anchor members 307 a-307 c can be formed from a similar or substantially identical material to that of left anchor members 305 a-305 d, such as for example, Nitinol wire, and/or other memory materials or similarly-performing metals, alloys, polymers, or the like. As previously mentioned, the closure devices shown and/or described herein as devices 300 a-b (or other) can be used in heart atria, hence the references in some of the description herein to the left �atrial anchor� and/or the right �atrial anchor�. It can be understood, however, that the structures and general function of the closure device can have applicability to other medical devices, and so can also be properly referred to generically as �right anchors� or �left anchors�. In particular, specific application to heart tissue is not required by the disclosed apparatus and methods. FIG. 16B shows a close up perspective view of the right atrial anchor 308 a shown in FIG. 16A, when in a stretched conformation (e.g., inside a catheter). In particular, FIG. 16B shows that the right atrial anchor 308 a includes two axially-positioned central hubs, one of which is a top central hub 314 a that is generally fixed on a longitudinal axis, such as being fixed to connector 306. The right atrial anchor 308 a also includes a lower central hub 310 a that is generally free to move away from or closer to top central hub 314 a. This also means that the lower central hub 310 a can move with respect to the left atrial anchor 304 (FIG. 16A). Anchor members 307 a-307 c can be formed by separate looped elements extending from corresponding perforations in the top central hub 314 a and lower central hub 310 a, and by joining the separate looped elements with a joining element 334, such as a metallic or polymeric fiber wrapped around the loop ends of each element. For example, FIG. 16C shows that the top central hub 314 a includes extensions 315 a-315 c, and that the lower central hub 310 a includes extensions 311 a-311 c. On top central hub 314 a, a top set of loops (i.e., portions of anchor members 307 a-307 c) 330 a-330 c include a filament, such as Nitinol wire, or similarly-performing material, which has been threaded through eyelets (not shown) in the extensions 315 a-315 c. Similarly, on lower central hub 310 a, a lower set of loops (i.e., corresponding other portions of anchor members 307 a-307 c) 332 a-332 c include similarly composed filament that has also been threaded through corresponding eyelets (not shown) in the extensions 311 a-311 c. It can be understood that multiple filaments can be used to create anchor members 307 a-307 c, at loops 330 a-330 c, and loops 332 a-332 c. In general, the size of the eyelets (not shown) in each top or lower central hub extension, and the size (i.e., diameter) of the filaments forming loops 330 a-330 c, and 332 a-332 c can be configured such that each resulting anchor members 307 a-307 c has a certain amount of independent flexibility, conformity, and/or curvature. In particular, each resulting anchor member 307 a-307 c of right atrial anchor 308 a is able to move at least somewhat independently of the next anchor member, allowing a variable degree of curvature and/or conformable fit against the corresponding atrial tissue at, for example, a tissue opening (e.g., a PFO opening) or the like. Furthermore, independent conformance against tissue can be particularly helpful with curved and/or trabeculated tissues, such as ventricles, which are irregular, complex architectures. In addition, the shape(s) of the three or more right anchor members in the top central hub 314 a and the lower central hub 310 a can be varied to also provide a variably conforming, or curved, independent fit against the heart tissue. One will also appreciate that this variably conforming, or curved, independent fitting can also be aided at least in part by the use of flexible memory materials in the right atrial anchor 308. For example, FIGS. 17A-17E illustrate a wide variety of conformations that can be achieved using different widths, heights, shapes, and curvatures of the loops in hubs 310 (e.g., lower hubs 310 a-310 e) and 314 (e.g., top hubs 314 a-314 e). These different overlays and conformations can each provide unique advantages for fitting against, or curving about, and hence closing a tissue opening, such as the PFO opening described previously. For instance, one configuration can have an increased density of loops at its center and lesser coverage at its periphery, while another configuration can have a generally uniform loop density. In still another configuration, there can be an increased density of loops at the periphery when compared to the center of the anchor. Each configuration provides different surface area coverage and different properties to aid with tissue growth and closure of the PFO. Of course, other sorts of tissue openings that can be aided by these and the other foregoing apparatus configurations include ASDs, VSDs, and PDA septal defects, and/or other defects, openings, or holes of internal tissue. FIG. 16D illustrates an alternative embodiment of a closure device 300 a, where an alternative right atrial anchor 308 b comprises solid anchor members 307 a-307 c, which collapse or expand based on spring forces. For example, FIG. 16E shows a close up perspective view of the right atrial anchor 308 b show in FIG. 16D, where the anchor includes a top hub 342, which is generally fixed to the connector 306. The right atrial anchor 308 b also includes a lower central hub 340 that is free to move toward or away from the top central hub 342. As shown, the filaments forming anchor members 307 a-307 c comprise single filaments, such as Nitinol wire, or other similarly performing metals, alloys or polymers, which directly connect the top central hub 342 with the lower central hub 340. In operation, these filaments can be configured to be stretched apart for placement inside catheter 312, and to naturally compress into the configuration illustrated in FIG. 16D when pushed out of the catheter 312. In addition, FIGS. 16A and 16D (also FIGS. 18A-18C) also show that the left atrial anchor 304 can include three or more anchor members 305 a-305 d. FIGS. 16A, 16D, and 18A-C specifically show four anchor members. These are simply another embodiment of a left anchor, which is shown for purposes of breadth. In particular, the left anchor 304 shown in FIGS. 16A and 16C can comprise three or more anchor, members 305 a-d, which fold along the longitudinal axis defined by connector 306 and/or stem 316 when inside the catheter. The illustrated left anchor members 305 a-d of left anchor 304 can then expand into the conformation shown in FIGS. 16A and 16D when released from the catheter. Of course, left anchor 304 can be substituted with any of the left anchors (or �left atrial anchors�) shown or described herein. FIGS. 16A and 16D further show that the left atrial anchor 304 can include one or more growth stimulating filaments or structures 302 placed about the anchor members 305 a-d. The one or more growth stimulating fibers or substances 302 can also be placed about the anchor members of the right anchors 308 a-c (e.g., FIGS. 16A-E and 18A-C). In one implementation, the one or more growth stimulating filaments or structures 302 can be an organic fiber which include any materials suitable for initiating or encouraging the growth of cellular tissue. For example, the organic fiber(s) 302 can include a DACRON fiber in one implementation, although other materials including bioresorbable polymers, drug eluting compositions, proteins, growth factors, or combinations thereof are also suitable. FIGS. 16A and 16D, and FIGS. 18A-18C further illustrate that the closure device 300 a can include an insertion device 316 referred to generally as a �stem�. In some implementations, the stem 316 is alternately referred to as an advancer 308, such as similar to advancer 280, which can be used to at least partially position and release the closure device 300 a into a preferred position about the septum primum 52 and the septum secundum 54 (FIG. 1B). For example, a user can force the exit of a given left and/or right atrial anchor by forcing the stem 316 along the catheter 312 pathway, and ultimately out of the catheter 312 opening, as previously described herein for other or similar cases. When the given left or right atrial anchor, such as left atrial anchor 304 in FIG. 18, is forced out of the catheter 312, the memory materials of the given atrial anchor cause the atrial anchor to naturally relax, and ultimately conform about the oz relevant tissue opening. Since the closure device 300 a includes essentially two three-or-more-membered anchors of essentially the same flexible material, the action for positioning, and relaxing of the left atrial anchor 304 is substantially similar to the positioning, and relaxing of the right atrial anchor 308. This contrasts somewhat with the different actions of the left and right atrial anchor shown in FIGS. 12A and 12B, and therefore represents an alternative mechanism for positioning atrial anchors. As such, the right atrial anchor 308 of closure device 300 a may have a more fitted conformation about the septum secundum 54 than otherwise available in some situations. FIGS. 18A-18C also show how the stem 316 can be configured with partial detachment means, or one or more components configured to at least reversibly, and/or partially, release the right atrial anchor in stages. In some cases, this ability for partial detachment may be helpful, for example, when viewing the progress of positioning the closure device. Thus, FIG. 18A shows that when left atrial anchor 304 and right atrial anchor 308 c have exited the catheter 312, and have been appropriately positioned, the user can use partial detachment means to release the right anchor 308 c from the stem 316, while maintaining control of the right anchor 308 c via flexible filament 320. To accomplish this, FIG. 18B shows that right atrial anchor 308 c includes a distal hub 322 and a proximal hub 324. A flexible filament 320, such as a memory material, extends through stem 316, and screws into a threaded portion of the distal hub 322. By contrast, stem 316 is also threaded, and screws together with corresponding threads of proximal hub 324. In one exemplary operation, the user can insert the closure device 300 b into the appropriate portions about the relevant tissue opening, such as the PFO opening. The user then uses the partial detachment means to release the stem 316 from the proximal hub 324 by unscrewing the stem 316 from the threads of the proximal hub 324. At least in part since the filament 320 is flexible, the right atrial anchor is free to relax into a natural, fitted conformation about relevant tissue (e.g., PFO opening), even though the filament 320 is still connected to distal hub 322. As such, at least some control is still maintained of the distal hub 322 at least in part due to the connection of the filament 320. The user can then withdraw the stem 316 at least partially, and view the positioning of the left and right atrial anchors through, for example, X-ray. If the user is satisfied with the placement of the right atrial anchor 308 c, the user can then remove the remainder of the partial detachment means by unscrewing the filament 320 from the threads of the distal hub 322. Alternatively, if the user decides that a different placement of the right atrial anchor 308 c is preferred, the user can use the flexible filament 320 as a guide to reposition the stem 316 against proximal hub 324, and reattach the stem 316 with the proximal hub (e.g., screwing together). The user can then reposition the right atrial anchor 308 c as appropriate about the septum secundum 54, and/or other proximate tissues. FIG. 19 illustrates still a further implementation of a closure device (closure device 300 c), which is substantially similar in most respects to the closure devices 300 a-b disclosed above, except further showing another embodiment of a right anchor�right anchor 308 d. In particular, FIG. 19 shows that the closure device 300 c can include a right anchor 308 d that is based primarily on a single hub that is similar in respects to lower central hub 310 a. As shown, flexible filaments, such as Nitinol, or other similarly performing metals, alloys, or polymers, are threaded through extensions 311 a-c to form independent-action anchor members 307 d-f. In this embodiment, the anchor members 307 d-f are curved somewhat toward the direction of left anchor 304, which can enhance the fit against the relevant internal tissue. As with previous embodiments, the design of the right atrial anchor 308 d also provides for independently conforming anchor members 307 d-f, which also can enhance the fit against the relevant internal tissue. FIGS. 20A-20B depict two different orientations of the right atrial anchor 308 a, wherein the right atrial anchor is positioned about a septum secundum 54 in anatomical conformance with the septum secundum. These FIGS. 20A-20B are similar in most respects to that depicted in FIGS. 8A-8D, except showing a three-anchor-membered right atrial anchor 308 a. As shown, the right atrial anchor 308 a is preferably curved (e.g., FIG. 19) with an arch that is similar to that of the septum secundum 54. Right atrial anchor 308 a has an arched top surface that is similar in shape to superior aspect 53 (e.g., FIG. 1C), which is the attachment location of septum secundum 54 to septum primum. Right atrial anchor 308 a also has a length which permits it to be tucked under the overhang of septum secundum 54. For example, FIG. 20A shows anchor members 307 a-b tucked into pocket 59 a (see also FIG. 8A), while FIG. 20B shows only anchor member 307 b tucked into pocket 59 a. FIG. 8B shows anchor member 307 b positioned within pocket 59 p and the other end positioned on top of anterior portion 57 a instead of in pocket 59 a. As described above, relying on the anatomy of the posterior portion 57 p of septum secundum 54 to position at least one end of right atrial anchor is an effective methodology for effectively closing a tissue opening, such as PFO. The ends of right atrial anchor 308 a are configured to conform with the anatomy of a portion of the septum secundum. These embodiments of the right atrial anchor 308 a, as with those described in FIGS. 8A-8D, facilitate closure of the tissue opening by allowing the right atrial anchor 308 a to be tucked under at least a portion of the septum secundum 54, and against the septum primum 52, such that the right atrial anchor 308 a can be drawn taughtly against both the septum primum 52 and septum secundum 54. Healing is thereby facilitated along a greater portion of PFO tunnel 58. Accordingly, the present invention provides a number of implementations with differing advantages for closing tissue openings that are otherwise difficult to access or close efficiently, such as a PFO opening. The entirety of all publications cited in this specification, including but not limited to patents and patent applications, are incorporated by reference herein. The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore, indicated by the appended claims rather than by the foregoing description. All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope. 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Gore & Associates, Inc.Sealing device and delivery system* Cited by examinerClassifications U.S. Classification606/213International ClassificationA61B17/08, A61D1/00, A61B, A61B17/00Cooperative ClassificationA61B2017/00575, A61B2017/00867, A61B2017/00606, A61B2017/00619, A61B2017/00615, A61B17/0057, A61B2017/00592, A61B2017/00623, A61B2017/00893European ClassificationA61B17/00PLegal EventsDateCodeEventDescriptionJan 20, 2010ASAssignmentOwner name: ZIONS FIRST NATIONAL BANK, UTAHFree format text: SECURITY AGREEMENT;ASSIGNOR:COHEREX MEDICAL, INC.;REEL/FRAME:023820/0552Effective date: 20100119May 16, 2005ASAssignmentOwner name: PROXIMARE, INC., UTAHFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WHISENANT, BRIAN K.;DAVIS, CLARK C.;EDMISTON, DARYL R.;REEL/FRAME:016218/0704Effective date: 20050418RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services