Source: http://www.google.fr/patents/US8150508
Timestamp: 2013-06-19 18:25:31
Document Index: 578250592

Matched Legal Cases: ['Application No. 2007233205', 'Application No. 07759710', 'Application No. 07759710', 'Application No. 07759722', 'Application No. 07759722', 'Application No. 07759728', 'Application No. 07759728', 'Application No. 2007233135', 'Application No. 194406', 'Application No. 194407']

Brevet US8150508 - Vagus nerve stimulation method - Google�BrevetsRecherche Images Maps Play YouTube Actualit�s Gmail Drive Plus » Recherche avanc�e dans les brevets | Historique Web | Connexion Recherche avanc�e dans les brevets BrevetsAn implanted electrical signal generator delivers a novel exogenous electrical signal to a vagus nerve of a patient. The vagus nerve conducts action potentials originating in the heart and lungs to various structures of the brain, thereby eliciting a vagal evoked potential in those structures. The exogenous...http://www.google.fr/patents/US8150508?utm_source=gb-gplus-shareBrevet US8150508 - Vagus nerve stimulation method Num�ro de publicationUS8150508 B2Type de publicationOctroi Num�ro de demande11/693,421 Date de publication3 avr. 2012 Date de d�p�t29 mars 2007 Date de priorit�29 mars 2006Autre r�f�rence de publicationCA2653110A1, CA2653112A1, EP2004283A1, EP2007477A1, EP2026874A1, US8219188, US8280505, US20070233192, US20070233193, US20070233194, US20090171405, US20090177252, US20100063563, US20120191158, WO2007115103A1, WO2007115113A1, WO2007115118A1 Num�ro de publication11693421, 693421, US 8150508 B2, US 8150508B2, US-B2-8150508, US8150508 B2, US8150508B2 InventeursArthur D. Craig Cessionnaire d'origineCatholic Healthcare WestCitations de brevets (100), Citations hors brevets (64), Classifications (17) Liens externes: USPTO, Cession USPTO, EspacenetVagus nerve stimulation methodUS 8150508 B2 R�sum� An implanted electrical signal generator delivers a novel exogenous electrical signal to a vagus nerve of a patient. The vagus nerve conducts action potentials originating in the heart and lungs to various structures of the brain, thereby eliciting a vagal evoked potential in those structures. The exogenous electrical signal simulates and/or augments the endogenous afferent activity originating from the heart and/or lungs of the patient, thereby enhancing the vagal evoked potential in the various structures of the brain. The exogenous electrical signal includes a series of electrical pulses organized or patterned into a series of microbursts including 2 to 20 pulses each. No pulses are sent between the microbursts. Each of the microbursts may be synchronized with the QRS wave portion of an ECG. The enhanced vagal evoked potential in the various structures of the brain may be used to treat various medical conditions including epilepsy and depression.
Citations de brevets Brevet cit� Date de d�p�t Date de publication D�posant TitreUS376081219 mars 197125 sept. 1973Regents University Minnesota,UsImplantable spiral wound stimulation electrodesUS37962217 juil. 197112 mars 1974N Us HagforsApparatus for delivering electrical stimulation energy to body-implanted apparatus with signal-receiving meansUS410746917 f�vr. 197715 ao�t 1978Rockwell International CorporationMultiplex/demultiplex apparatusUS430540229 juin 197915 d�c. 1981Katims; Jefferson J.Method for transcutaneous electrical stimulationUS43389452 mars 197913 juil. 1982Clinical Engineering Laboratory LimitedMethod and randomized electrical stimulation system for pain reliefUS44248129 oct. 198010 janv. 1984Cordis CorporationImplantable externally programmable microprocessor-controlled tissue stimulatorUS443100023 mai 198014 f�vr. 1984Gatron CorporationTranscutaneous nerve stimulator with pseusorandom pulse generatorUS445998930 juin 198117 juil. 1984Neuromed, Inc.Non-invasive multiprogrammable tissue stimulator and methods for useUS450386315 sept. 198112 mars 1985Katims; Jefferson J.Method and apparatus for transcutaneous electrical stimulationUS454143217 d�c. 198217 sept. 1985Neurotronic LteeElectric nerve stimulator deviceUS457348125 juin 19844 mars 1986Huntington Institute Of Applied ResearchImplantable electrode arrayUS457731613 f�vr. 198418 mars 1986Rca CorporationSynchronization system for a regenerative subtransponder satellite communication systemUS459094614 juin 198427 mai 1986Biomed Concepts, Inc.Surgically implantable electrode for nerve bundlesUS459233912 juin 19853 juin 1986Mentor CorporationGastric banding deviceUS460634910 juil. 198519 ao�t 1986Cordis CorporationImplantable cardiac pacer having dual frequency programming and bipolar/unipolar lead programmabilityUS460898511 oct. 19842 sept. 1986Case Western Reserve UniversityAntidromic pulse generating wave form for collision blockingUS461293416 juil. 198423 sept. 1986Borkan; William N.Non-invasive multiprogrammable tissue stimulatorUS462530830 nov. 198225 nov. 1986American Satellite CompanyAll digital IDMA dynamic channel allocated satellite communications system and methodUS462894211 oct. 198416 d�c. 1986Case Western Reserve UniversityAsymmetric shielded two electrode cuffUS464993611 oct. 198417 mars 1987Case Western Reserve UniversityAsymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blockingUS470225430 d�c. 198527 oct. 1987Zabara; JacobNeurocybernetic prosthesisUS47933537 mai 198627 d�c. 1988Borkan; William N.Non-invasive multiprogrammable tissue stimulator and methodUS486716426 oct. 198719 sept. 1989Zabara; JacobNeurocybernetic prosthesisUS492097912 oct. 19881 mai 1990Huntington Medical Research InstituteBidirectional helical electrode for nerve stimulationUS49497214 ao�t 198921 ao�t 1990Ito Co., Ltd.Transcutaneous electric nerve stimulaterUS497789522 mai 198918 d�c. 1990Ely Shavit PasternakElectrical apparatus for medical treatmentUS502580725 janv. 198925 juin 1991Zabara; JacobNeurocybernetic prosthesisUS508198713 mars 199021 janv. 1992Siemens AktiengesellschaftImplantable medical device for stimulating a physiological event of a living being with stimulation intensity adaptable to physical activity of the living beingUS515417213 nov. 198913 oct. 1992Cyberonics, Inc.Constant current sources with programmable voltage sourceUS51799505 d�c. 199119 janv. 1993Cyberonics, Inc.Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulationUS51861705 d�c. 199116 f�vr. 1993Cyberonics, Inc.Simultaneous radio frequency and magnetic field microprocessor reset circuitUS51881041 f�vr. 199123 f�vr. 1993Cyberonics, Inc.Treatment of eating disorders by nerve stimulationUS520528514 juin 199127 avr. 1993Cyberonics, Inc.Voice suppression of vagal stimulationUS52150863 mai 19911 juin 1993Cyberonics, Inc.Therapeutic treatment of migraine symptoms by stimulationUS522249431 juil. 199129 juin 1993Cyberonics, Inc.Implantable tissue stimulator output stabilization systemUS52319889 ao�t 19913 ao�t 1993Cyberonics, Inc.Treatment of endocrine disorders by nerve stimulationUS52359805 d�c. 199117 ao�t 1993Cyberonics, Inc.Implanted apparatus disabling switching regulator operation to allow radio frequency signal receptionUS52634807 ao�t 199223 nov. 1993Cyberonics, Inc.Treatment of eating disorders by nerve stimulationUS526930322 f�vr. 199114 d�c. 1993Cyberonics, Inc.Treatment of dementia by nerve stimulationUS52995693 mai 19915 avr. 1994Cyberonics, Inc.Treatment of neuropsychiatric disorders by nerve stimulationUS530420618 nov. 199119 avr. 1994Cyberonics, Inc.Activation techniques for implantable medical deviceUS533050724 avr. 199219 juil. 1994Medtronic, Inc.Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmiasUS533051517 juin 199219 juil. 1994Cyberonics, Inc.Treatment of pain by vagal afferent stimulationUS533422130 juin 19932 ao�t 1994Medtronic, Inc.Method and apparatus for treatment of angina sameUS53356573 mai 19919 ao�t 1994Cyberonics, Inc.Therapeutic treatment of sleep disorder by nerve stimulationUS535432014 sept. 199211 oct. 1994Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo BerlinNeurostimulator for production of periodic stimulation pulsesUS541153123 sept. 19932 mai 1995Medtronic, Inc.Method and apparatus for control of A-V intervalUS54115403 juin 19932 mai 1995Massachusetts Institute Of TechnologyMethod and apparatus for preferential neuron stimulationUS542387226 mai 199313 juin 1995Cigaina; ValerioProcess and device for treating obesity and syndromes related to motor disorders of the stomach of a patientUS55077846 avr. 199516 avr. 1996Medtronic, Inc.Method and apparatus for control of A-V intervalUS552286221 sept. 19944 juin 1996Medtronic, Inc.Method and apparatus for treating obstructive sleep apneaUS552286512 oct. 19944 juin 1996Alfred E. Mann Foundation For Scientific ResearchVoltage/current control system for a human tissue stimulatorUS55407306 juin 199530 juil. 1996Cyberonics, Inc.Treatment of motility disorders by nerve stimulationUS554073428 sept. 199430 juil. 1996Zabara; JacobCranial nerve stimulation treatments using neurocybernetic prosthesisUS557115019 d�c. 19945 nov. 1996Cyberonics, Inc.Treatment of patients in coma by nerve stimulationUS560161726 avr. 199511 f�vr. 1997Advanced Bionics CorporationMultichannel cochlear prosthesis with flexible control of stimulus waveformsUS56113508 f�vr. 199618 mars 1997John; Michael S.Method and apparatus for facilitating recovery of patients in deep comaUS564557017 juin 19948 juil. 1997Sorin Biomedica S.P.A.Method and device for monitoring and detecting sympatho-vagal activity and for providing therapy in response theretoUS565137820 f�vr. 199629 juil. 1997Cardiothoracic Systems, Inc.Method of using vagal nerve stimulation in surgeryUS565831828 sept. 199519 ao�t 1997Pacesetter AbMethod and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonomic nerve system to the heart, and for administrating anti-arrhythmia therapy in response theretoUS569068129 mars 199625 nov. 1997Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillationUS569068812 nov. 199625 nov. 1997Pacesetter AbMedical therapy apparatus which administers therapy adjusted to follow natural variability of the physiological function being controlledUS56906918 mai 199625 nov. 1997The Center For Innovative TechnologyGastro-intestinal pacemaker having phased multi-point stimulationUS570028213 oct. 199523 d�c. 1997Zabara; JacobHeart rhythm stabilization using a neurocybernetic prosthesisUS57024281 ao�t 199630 d�c. 1997Axelgaard Manufacturing Company, Ltd.Electrical stimulation for treatment of incontinence and other neuro-muscular disordersUS57024294 avr. 199630 d�c. 1997Medtronic, Inc.Neural stimulation techniques with feedbackUS570740019 sept. 199513 janv. 1998Cyberonics, Inc.Treating refractory hypertension by nerve stimulationUS57557508 nov. 199626 mai 1998University Of FloridaMethod and apparatus for selectively inhibiting activity in nerve fibersUS57922127 mars 199711 ao�t 1998Medtronic, Inc.Nerve evoked potential measurement system using chaotic sequences for noise rejectionUS58004741 nov. 19961 sept. 1998Medtronic, Inc.Method of controlling epilepsy by brain stimulationUS58140928 mai 199729 sept. 1998Medtronic Inc.Neural stimulation techniques with feedbackUS583699430 avr. 199717 nov. 1998Medtronic, Inc.Method and apparatus for electrical stimulation of the gastrointestinal tractUS586101430 avr. 199719 janv. 1999Medtronic, Inc.Method and apparatus for sensing a stimulating gastrointestinal tract on-demandUS59138825 juin 199822 juin 1999Medtronic Inc.Neural stimulation techniques with feedbackUS591623924 nov. 199729 juin 1999Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillationUS59282722 mai 199827 juil. 1999Cyberonics, Inc.Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activityUS594190615 oct. 199724 ao�t 1999Medtronic, Inc.Implantable, modular tissue stimulatorUS59958686 janv. 199730 nov. 1999University Of KansasSystem for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subjectUS600296623 avr. 199614 d�c. 1999Advanced Bionics CorporationMultichannel cochlear prosthesis with flexible control of stimulus waveformsUS601644927 oct. 199718 janv. 2000Neuropace, Inc.System for treatment of neurological disordersUS604125827 juil. 199821 mars 2000Transneuronix, Inc.Medical stimulationUS607304817 nov. 19956 juin 2000Medtronic, Inc.Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failureUS608324924 sept. 19984 juil. 2000Medtronic, Inc.Apparatus for sensing and stimulating gastrointestinal tract on-demandUS610141221 d�c. 19998 ao�t 2000Duke UniversityCompositions, apparatus and methods for facilitating surgical proceduresUS610495515 d�c. 199715 ao�t 2000Medtronic, Inc.Method and apparatus for electrical stimulation of the gastrointestinal tractUS610495630 mai 199715 ao�t 2000Board Of Trustees Of Southern Illinois UniversityMethods of treating traumatic brain injury by vagus nerve stimulationUS611562829 mars 19995 sept. 2000Medtronic, Inc.Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signalsUS613236115 ao�t 199717 oct. 2000Emory UniversityTranscranial brain stimulationUS614159025 sept. 199731 oct. 2000Medtronic, Inc.System and method for respiration-modulated pacingUS616104423 nov. 199812 d�c. 2000Synaptic CorporationMethod and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulationUS616731114 juin 199926 d�c. 2000Electro Core Techniques, LlcMethod of treating psychological disorders by brain stimulation within the thalamusUS617576425 janv. 200016 janv. 2001Advanced Bionics CorporationImplantable microstimulator system for producing repeatable patterns of electrical stimulationUS618892915 juil. 199913 f�vr. 2001Joseph GiordanoSequentially generated multi-parameter bio-electric delivery system and methodUS621958028 mai 199917 avr. 2001Advanced Bionics CorporationMultichannel cochlear prosthesis with flexible control of stimulus waveformsUS622190831 d�c. 199824 avr. 2001Scientific Learning CorporationSystem for stimulating brain plasticityUS623842330 sept. 199929 mai 2001Medtronic, Inc.Apparatus and method for treating chronic constipationUS624970410 ao�t 199919 juin 2001Advanced Bionics CorporationLow voltage stimulation to elicit stochastic response patterns that enhance the effectiveness of a cochlear implantUS62531095 nov. 199826 juin 2001Medtronic Inc.System for optimized brain stimulationUS62665643 nov. 199924 juil. 2001Medtronic, Inc.Method and device for electronically controlling the beating of a heartUS20040254616 *5 avr. 200416 d�c. 2004Cvrx, Inc.Stimulus regimens for cardiovascular reflex control* Cit� par l'examinateurCitations hors brevetsR�f�rence1Bachman, D.,S. et al.; "Effects of Vagal Volleys and Serotonin on Units of Cingulate Cortex in Monkeys;" Brain Research , vol. 130 (1977). pp. 253-269.2Bohning, D.E., et al.; "Feasibility of Vagus Nerve Stimulation-Synchronized Blood Oxygenation Level-Dependent Functional MRI;" A Journal of Clinical and Laboratory Research: Investigative Radiology; vol. 36, No. 8 (Aug. 2001); pp. 470-479.3Bohning, D.E., et al.; "Feasibility of Vagus Nerve Stimulation�Synchronized Blood Oxygenation Level-Dependent Functional MRI;" A Journal of Clinical and Laboratory Research: Investigative Radiology; vol. 36, No. 8 (Aug. 2001); pp. 470-479.4Boon, Paul, et al.; "Programmed and Magnet-Induced Vagus Nerve Stimulation for Refractory Epilepsy;" Journal of Clinical Neurophysiology vol. 18 No. 5; (2001); pp. 402-407.5Clark, K.B., et al.; "Enhanced Recognition Memory Following Vagus Nerve Stimulation in Human Subjects;" Nature Neuroscience, vol. 2, No. 1, (Jan. 1999) pp. 93-98.6Clark, K.B., et al.; "Posttraining Electrical Stimulation of Vagal Afferents with Concomitant Vagal Efferent Inactivation Enhances Memory Storage Processes in the Rat;" Neurobiology of Learning and Memory, vol. 70, 364-373 (1998) Art. No. NL983863.7Craig, A.D. (Bud), Mechanisms of Thalamic Pain; Central Neuropathic Pain; Focus on Poststroke Pain, 2007, IASP Press, Seattle, Washington.8Craig, A.D. (Bud), Vagal Input to Lateral Area 3a in Cat Cortex; J. Neurophysiol 90, Jan. 15, 2003, 143-154; USA.9Craig, A.D. (Bud); "Distribution of Trigeminothalamic and Spinothalamic Lamina I Terminations in the Macaque Monkey; " The Journal of Comparative Neurology, vol. 477, pp. 119-148 (2004).10DeGiorgo, Christopher M., et al.; "Vagus Nerve Stimulation: Analysis of Device Parameters in 154 Patients During the Long-Term XE5 Study;" Epilepsia, vol. 42, No. 8; pp. 1017-1020 (2001).11Devous, Michael D., et al.; "Effects of Vagus Nerve Stimulation on Regional Cerebral Blood Flow in Treatment-Resistant Depression;" National Institute of Mental Health-42nd Annual NCDEU Meeting: Poster Session II; Poster Abstracts, Jun. 10-13, 2002, 1 page; http://www.nimh.nih.gov/ncdeu/abstracts2002/ncdeu2019.cfm.12Devous, Michael D., et al.; "Effects of Vagus Nerve Stimulation on Regional Cerebral Blood Flow in Treatment-Resistant Depression;" National Institute of Mental Health�42nd Annual NCDEU Meeting: Poster Session II; Poster Abstracts, Jun. 10-13, 2002, 1 page; http://www.nimh.nih.gov/ncdeu/abstracts2002/ncdeu2019.cfm.13Dodrill, Ph.D., et al.; "Effects of Vagal Nerve Stimulation on Cognition and Quality of Life in Epilepsy;" Epilepsy and Behavior, vol. 2 (2001); pp. 46-53.14Examination Report in Australian Patent Application No. 2007233205, Mailing Date: Aug. 9, 2010.15Examination Report in European Patent Application No. 07759710.2, Mailing Date: Apr. 13, 2010.16Examination Report in European Patent Application No. 07759710.2, Mailing Date: Jun. 10, 2009.17Examination Report in European Patent Application No. 07759722.7, Mailing Date: Apr. 27, 2010.18Examination Report in European Patent Application No. 07759722.7, Mailing Date: Jun. 16, 2009.19Examination Report in European Patent Application No. 07759728.4, Mailing Date: Apr. 27, 2010.20Examination Report in European Patent Application No. 07759728.4, Mailing Date: Aug. 8, 2009.21Examiner's First Report in Australian Patent Application No. 2007233135, Mailing Date: Aug. 9, 2010.22Fanselow, E. E., et al.; "Reduction of Pentylenetetrazole-Induced Seizure Activity in Awake Rats by Seizure-Triggered Trigeminal Nerve Stimulation;" The Journal of Neuroscience, vol. 20, No. 21; (Nov. 2000); pp. 8160-8168.23Final Office Action in U.S. Appl. No. 11/693,451, Mailing Date: Oct. 22, 2010.24Final Office Action in U.S. Appl. No. 12/401,206, Mailing Date: Nov. 15, 2010.25First Office Action in U.S. Appl. No. 11/693,451, Apr. 21, 2010.26First Office Action in U.S. Appl. No. 12/401,026, Apr. 19, 2010.27George, M.S., et al.; "Open Trial of VNS Therapy in Severe Anxiety Disorders;" 156th American Psychiatric Association Annual Meeting; May 17-22, 2003.28George, M.S., et al.; "Vagus Nerve Stimulation: A New Tool for Brain Research and Therapy;" Society of Biological Psychiatry vol. 47 (2000) pp. 287-295.29Hallowitz, R.A., et al.; "Effects of Vagal Tolleys on Units of Intralaminar and Juxtalaminar Thalamic Nuclei in Monkeys; " Brain Research, vol. 130 (1977), pp. 271-286.30Harry, J.D., et al.; "Balancing Act: Noise is the Key to Restoring the Body's Sense of Equilibrium;" IEEE Spectrum (Apr. 2005)pp. 37-41.31Henry, MD, T.R.; "Therapeutic Mechanisms of Vagus Nerve Stimulation" Neurology, vol. 59 Suppl. 4 (Sep. 2002); pp. S3-S14.32Henry, T.R., et al.; "Brain Blood-Flow Alterations Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy: I. Acute Effects at High and Low Levels of Stimulation; " Epilepsia vol. 39, No. 9; pp. 984-990 (1998).33Israeli Patent Application No. 194406: Official Action issued by the State of Israel Department of Justice on Oct. 20, 2010, 4 pages.34Israeli Patent Application No. 194407: Official Action issued by the State of Israel Department of Justice on Oct. 21, 2010, 4 pages.35Ito, S.; Craig, A.D., Forebrain Projections from Different Portions of the Vagal Responsive Region in the Thalamic Parafascicular Nucleus in Monkeys; Oct. 15, 2006; Program 166.9/AA28, USA.36Ito, S.; Craig, A.D., Forebrain Projections of the Vagal Responsive Site in the Thalamic Parafascicular Nucleus in Monkeys; Nov. 13, 2005; Presentation 305.2, Washington D.C.37Ito, S.; Craig, A.D., Vagal-Evoked Activity in the Parafascicular Nucleus of the Primate Thalamus; J. Neurophysiol 94, May 31, 2005, 2976-2982; USA.38King, M.D., "Effects of Short-Term Vagus Nerve Stimulation (VNS) on FOS Expression in Rat Brain Nuclei" 58th Annual Scientific Convention of the Society of Biological Psychiatry, (May 2003).39Klapper, M.D., et al., "VNS Therapy Shows Potential Benefit in Patients with Migraine and Chronic Daily Headache After 3 to 6 Months of Treatment (Preliminary Results)" 45th Annual Scientific Meeting of the American Headache Society (Jun. 2003).40Koo, B., "EEG Changes With Vagus Nerve Stimulation" Journal of Clinical Neurophysiology, vol. 18 No. 5 (Sep. 2001); pp. 434-441.41Labar, D., "Vagus Nerve Stimulation for 1 Year in 269 patients on Unchanged Antiepilectic Drugs" Seizure vol. 13, (2004) pp. 392-398.42Liebman, K.M. et al.; "Improvement in Cognitive Function After Vagal Nerve Stimulator Implantation;" Epilepsia, vol. 39, Suppl. 6 (1998) 1 page.43Lockard et al., "Feasibility and Safety of Vagal Stimulation in Monkey Model; " Epilepsia, vol. 31 (Supp. 2) (1990), pp. S20-S26.44Malow, B.A., et al.; "Vagus Nerve Stimulation Reduces Daytime Sleepiness in Epilepsy Patients" Neurology 57 (2001) pp. 879-884.45McClintock, P., "Can Noise Actually Boost Brain Power" Physics World Jul. 2002; pp. 20-21.46Mori, T., et al.; "Noise-Induced Entrainment and Stochastic Resonance in Human Brain Waves" Physical Review Letters vol. 88, No. 21 (2002); pp. 218101-1-218101-4.47Non-final U.S. Office Action, notification date Mar. 16, 2010 U.S. Appl. No. 11/693,499.48Non-final U.S. Office Action, notification date Mar. 17, 2010, U.S. Appl. No. 12/400,893.49Office Action in U.S. Appl. No. 11/693,499, Mailing Date: Sep. 28, 2010.50Office Action in U.S. Appl. No. 12/400,893, Mailing Date: Aug. 10, 2010.51Rugg-Gunn, F.J., et al.; "Cardiac Arrhythmias in Focal Epilepsy: a Prospective Long-Term Study" www.thelancet.com vol. 364 (2004) pp. 2212-2219.52Rutecki, P.; "Anatomical, Physiological, and Theoretical Basis for the Antiepileptic Effect of Vagus Nerve Stimulation" Epilepsia, vol. 31 Suppl. 2; S1-S6 (1990).53Sahin, M.; et al.; "Improved Nerve Cuff Electrode Recordings with Subthreshold Anodic Currents;" IEEE Transactions on Biomedical Engineering, vol. 45, No. 8 (Aug. 1998) pp. 1044-1050.54Schachter, S.C., et al.; "Progress in Epilepsy Research: Vagus Nerve Stimulation;" Epilepsia, vol. 39, No. 7 (1998) pp. 677-686.55Tatum, W.O., et al.; "Vagus Nerve Stimulation and Drug Reduction" Neurology, vol. 56, No. 4 (Feb. 2001) pp. 561-563.56Tatum, W.O., et al.; "Ventricular Asystole During Vagus Nerve Stimulation for Epilepsy in Humans" American Academy of Neurologgy (1999) p. 1267 (See also pp. 1117, 1166, and 1265).57Terry et al.; "The Implantable Neurocybernetic Prosthesis System", Pacing and Clinical Electrophysiology, vol. 14, No. 1 (Jan. 1991), pp. 86-93.58Tubbs, R.S., et al.; "Left-Sided Vagus Nerve Stimulation Decreases Intracranial Pressure Without Resultant Bradycardia in the Pig: A Potential Therapeutic Modality for Humans" Child's Nervous System Original Paper; Springer-Verlag 2004.59Valdez-Cruz, A., et al.; "Chronic Stimulation of the Cat Vagus Nerve Effect on Sleep and Behavior" Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 26 (2002) pp. 113-118.60Vonck, K., et al. "The Mechanism of Action of Vagus Nerve Stimulation for Refractory Epilepsy-The Current Status", Journal of Neurophysiology, vol. 18 No. 5 (2001), pp. 394-401.61Vonck, K., et al. "The Mechanism of Action of Vagus Nerve Stimulation for Refractory Epilepsy�The Current Status", Journal of Neurophysiology, vol. 18 No. 5 (2001), pp. 394-401.62Ward, H., M.D., et al.; "Treatment-Refractory Obsessive-Compulsive Disorder: Potential Benefit of VNS Therapy" 23rd Annual Conference of the Anxiety Disorders Association of America (2007).63Woodbury, et al., "Vagal Stimulation Reduces the Severity of Maximal Electroshock Seizures in Intact Rats. Use of a Cuff Electrode for Stimulating and Recording"; Pacing and Clinical Electrophysiology, vol. 14 (Jan. 1991), pp. 94-107.64Zabara, J. "Inhibition of Experimental Seizures in Canines by Repetivie Vagal Stimulation" Epilepsia vol. 33, No. 6 (1992); pp. 1005-1012.Classifications Classification aux �tats-Unis607/2, 607/1, 607/45, 607/9, 607/6, 607/115, 607/119, 607/7, 607/118 Classification internationaleA61N1/36 Classification coop�rativeA61B5/0476, A61N1/36114, A61N1/36082 Classification europ�enneA61N1/36Z3J, A61N1/36, A61N1/36Z, A61N1/36Z3EFaire pivoterImage d'origineAccueil Google - Plan du site - T�l�chargements par lot sur l'USPTO - R�gles de confidentialit� - Conditions d'utilisation - � propos de Google�Brevets - Envoyer des commentairesDonn�es fournies par IFI CLAIMS Patent Services©2012 Google