Source: http://www.google.fr/patents/US6264924
Timestamp: 2013-06-19 13:30:03
Document Index: 64815367

Matched Legal Cases: ['in Fine', 'Application No. 0', 'application No. 09', 'application No. 09', 'application No. 09', 'application No. 09']

Brevet US6264924 - Oral care compositions comprising chlorite and methods - Google�BrevetsRecherche Images Maps Play YouTube Actualit�s Gmail Drive Plus » Recherche avanc�e dans les brevets | Historique Web | Connexion Recherche avanc�e dans les brevets BrevetsThe present invention relates to oral care chewing gum composition comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition in use is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially...http://www.google.fr/patents/US6264924?utm_source=gb-gplus-shareBrevet US6264924 - Oral care compositions comprising chlorite and methods Num�ro de publicationUS6264924 B1Type de publicationOctroi Num�ro de demande09/481,624 Date de publication24 juil. 2001 Date de d�p�t12 janv. 2000 Date de priorit�27 f�vr. 1998Autre r�f�rence de publicationCA2321232A1, CA2321232C, DE69904301D1, DE69904301T2, EP1056438A1, EP1056438B1, US6077502, WO1999043294A1 Num�ro de publication09481624, 481624, US 6264924 B1, US 6264924B1, US-B1-6264924, US6264924 B1, US6264924B1 InventeursJonathan James Witt, Rohan Lalith Wimalasena, Andrew Lee Wong, Altman Goulbourne Eric Jr. Cessionnaire d'origineThe Procter & Gamble CompanyCitations de brevets (68), Citations hors brevets (7), R�f�renc� par (4), Classifications (14) Liens externes: USPTO, Cession USPTO, EspacenetOral care compositions comprising chlorite and methodsUS 6264924 B1 R�sum� The present invention relates to oral care chewing gum composition comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition in use is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating breath malodor in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
What is claimed is: 1. An oral care chewing gum composition comprising:
(a) a safe and effective amount of chlorite ion; and (b) a pharmaceutically-acceptable chewing gum oral carrier; wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 50 ppm and the pH of the composition in use is greater than 7. 2. The composition of claim 1 comprising from about 0.1 mg to about 12 mg of chlorite ion.
3. The composition of claim 1 wherein the composition comprises from about 1 mg to about 6 mg of chlorite ion.
4. The composition of claim 1 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 25 ppm.
5. The composition of claim 1 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 15 ppm.
6. The composition of claim 1 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 10 ppm.
7. The composition of claim 1 wherein the final composition is essentially free of chlorine dioxide or chlorous acid.
8. A method for the treatment or prevention of periodontal disease, plaque, gingivitis, and breath malodor, by mastication of an oral care chewing gum composition comprising:
(a) a safe and effective amount of chlorite ion; and (b) a pharmaceutically-acceptable chewing gum oral carrier; wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 50 ppm and the pH of the composition in use is greater than 7.
9. The method of claim 8 wherein the composition comprises from about 0.1 mg to about 12 mg of chlorite ion.
10. The method of claim 8 wherein the composition comprises from about 1 mg to about 6 mg of chlorite ion.
11. The method of claim 8 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 25 ppm.
12. The method of claim 8 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 15 ppm.
13. The method of claim 8 wherein the final composition is essentially free of chlorine dioxide or chlorous acid.
14. An oral care chewing gum composition consisting essentially of
(a) a safe and effective amount of chlorite ion; and (b) a pharmaceutically-acceptable chewing gum oral carrier; (c) from about 0.05% to about 0.3% fluoride ion; wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 50 ppm and the pH of the final composition in use is greater than 7.
15. The method of claim 14 wherein the composition comprises from about 0.1 mg to about 12 mg of chlorite ion.
16. The method of claim 14 wherein the composition comprises from about 1 mg to about 6 mg of chlorite ion.
17. The method of claim 14 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 25 ppm.
18. The composition of claim 14 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 15 ppm.
19. The composition of claim 14 wherein the level of chlorine dioxide or chlorous acid in the final composition is less than about 10 ppm.
20. The composition of claim 14 wherein the final composition is essentially free of chlorine dioxide or chlorous acid.
This application is a division of Ser. No. 09/032238 filed Feb. 27, 1998, U.S. Pat. No. 6,077,502.
TECHNICAL FIELD The present invention relates to oral care chewing gum compositions, comprising an effective amount of chlorite ion. This invention further relates to a method for treating or preventing conditions of the oral cavity, such as gingivitis, plaque, periodontal disease, and/or breath malodor, as well as to a method for whitening teeth, in humans or other animals.
BACKGROUND ART Oral malodor, plaque, gingivitis, periodontal disease, and discoloration of the teeth, are all undesirable conditions that affect many people. First malodor of the oral cavity is also known as halitosis or bad breath. It is broadly estimated in the U.S. that 20-90 million individuals have oral malodor. It is generally believed that the cause of this condition is due to the presence of anaerobic bacteria, especially gram-negative anaerobic bacteria, in the mouth. These bacteria will generate volatile sulfur compounds (VSC) which are known to cause breath malodor.
It is recognized in the art that some breath malodor is caused by three chemical compounds. Specifically, these compounds are hydrogen sulfide (H�S�H), methyl mercaptan (CH3�S�H) and dimethyl sulfide (CH2�S�CH3). These compounds result from the degradation of epithelial cells and bacteria in the oral cavity. Specifically, the polypeptide chains of the epithelial cell walls, are composed of a series of amino acids including cysteine and methionine which contain sulfur side chains. The death of microorganisms or epithelial cells results in degradation of the polypeptide chains into their amino acid components, especially cysteine and methionine. Cysteine and methionine are precursors to the formation of VSC.
The prior art teaches a variety of ways to deliver chlorine dioxide, in oral care compositions, to the oral cavity. For example, U.S. Pat. No. 4,689,215 issued Aug. 25, 1987; U.S. Pat. No. 4,837,009 issued Jun. 6, 1989; U.S. Pat. No. 4,696,811, issued Sep. 29, 1987; U.S. Pat. No. 4,808,389 issued Feb. 28, 1989; U.S. Pat. No. 4,786,492 issued Nov. 22, 1988; U.S. Pat. No. 4,788,053 issued Nov. 29, 1988; U.S. Pat. No. 4,792,442 issued Dec. 20, 1988; U.S. Pat. No. 4,818,519 issued Apr. 4, 1989; U.S. Pat. No. 4,851,21 issued Jul. 25, 1989; U.S. Pat. No. 4,855,135 issued Aug. 8, 1989; U.S. Pat. No. 4,793,989 issued Dec. 27, 1988; U.S. Pat. No. 4,886,657 issued Dec. 12, 1989; U.S. Pat. No. 4,889,714 issued Dec. 26, 1989; U.S. Pat. No. 4,925,656 issued May 15, 1990; U.S. Pat. No. 4,975,285 issued Dec. 4, 1990; U.S. Pat. No. 4,978,535 issued Dec. 18, 1990; U.S. Pat. No. 5,200,171 issued Apr. 6, 1993; U.S. Pat. No. 5,348,734 issued Sep. 20, 1994; U.S. Pat. No. 5,618,550 issued Apr. 8, 1997, and U.S. Pat. No. 5,489,435 issued Feb. 6, 1996, all to Perry A. Ratcliffe, teach oral care compositions and methods of treatment using stabilized chlorine dioxide.
The above prior art references have not recognized that the delivery of chlorite ion, itself, to the oral cavity will provide efficacy in various oral care conditions. Because prior art references have focused on the delivery of chlorine dioxide for efficacy, prior art compositions and methods of treatment may have various drawbacks. For example, compositions comprising chlorine dioxide can exhibit aesthetic disadvantages such as �chlorine� (e.g. swimming pool) taste and smell. In addition due to the strong oxidizing capability of chlorine dioxide, compositions comprising chlorine dioxide may have certain stability disadvantages, especially in oral care formulations.
SUMMARY OF THE INVENTION The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, tooth gels, tooth powders, non-abrasive gels, chewing gums, mouth sprays, and lozenges (including breath mints), comprising:
DETAILED DESCRIPTION OF THE INVENTION The present invention relates to compositions and methods of treating or preventing diseases of the oral cavity (e.g. plaque, gingivitis, periodontal disease), breath malodor, and for whitening teeth, in humans or other animals, by topically applying to the oral cavity, a safe and effective amount of chlorite ion.
By �diseases or conditions of the oral cavity,� as used herein, is meant diseases of the oral cavity including periodontal disease, gingivitis, periodontitis, periodontosis, adult and juvenile periodontitis, and other inflammatory conditions of the tissues within the oral cavity, plus caries, necrotizing ulcerative gingivitis, and other conditions such as oral or breath malodor. Also specifically included are dentoalveolar infections, dental abscesses (e.g., cellulitis of the jaw; osteomyelitis of the jaw), acute necrotizing ulcerative gingivitis (i.e., Vincent's infection), infectious stomatitis (i.e., acute inflammation of the buccal mucosa), and Noma (i.e., gangrenous stomatitis or cancrum oris). Oral and dental infections are more fully disclosed in Finegold, Anaerobic Bacteria in Human Diseases, chapter 4, pp 78-104, and chapter 6, pp 115-154 (Academic Press, Inc., NY, 1977), the disclosures of which are incorporated herein by reference in their entirety. The compositions and methods of treatment of the present invention are particularly effective for treating or preventing periodontal disease (gingivitis and/or periodontitis) and breath malodor.
By �safe and effective amount� as used herein is meant an amount of a chlorite ion, high enough to significantly (positively) modify the condition to be treated or to effect the desired whitening result, but low enough to avoid serious side effects (at a reasonable benefit/risk ratio), within the scope of sound medical/dental judgment. The safe and effective amount of a chlorite ion, will vary with the particular condition (e.g., to effect whitening, to treat disease of the oral cavity or malodor) being treated, the age and physical condition of the patient being treated, the severity of the condition, the duration of treatment, the nature of concurrent therapy, the specific form (i.e., salt) of the chlorite source employed, and the particular vehicle from which the chlorite ion is applied.
By �toothpaste� as used herein is meant paste, powder, and tooth gel formulations unless otherwise specified.
By �oral care composition� or �oral composition� as used herein is meant a product which is not intentionally swallowed for purposes of systemic administration of therapeutic agents, but is retained in the oral cavity for a sufficient time to contact substantially all of the dental surfaces and/or oral mucosal tissues for purposes of oral activity.
By �essentially free of chlorous acid or chlorine dioxide� as used herein is meant a composition which comprises very low levels, e.g. less than about 5 ppm, preferably less than about 1 ppm of chlorine dioxide or chlorous acid, using known analytical methods for measuring chlorine dioxide or chlorous acid as disclosed hereinafter.
Analytical methods to measure the levels of chlorine dioxide or chlorous acid in the compositions of the present invention are known in the art. For example, L. S. Clesceri, A. E. Greenberg, and R. R. Trussel, Standard Methods for the Examination of Water and Wastewater, 17th ed., American Public Health Association, Washington, D.C., 1989, pp. 4-75 through 4-83; E. M. Aieta, P. V. Roberts, and M. Hernandez, J. Am. Water Works Assoc. 76(1), pp. 64-70 (1984); J. D. Pfaff and C. A. Brockhoff, J Am. Water Works Assoc. 82(4), pp. 192-195 (1990); G. Gordon, W. J. Cooper, R. G. Rice, and G. E. Pacey, J. Am. Water Works Assoc. 80(9), pp. 94-108 (1988); D. L. Harp, R. L. Klein, and D. J. Schoonover, J. Am. Water Works Assoc. 73(7), pp. 387-389 (1981); G. Gordon, W. J. Cooper, R. G. Rice, and G. E. Pacey, Am. Water Works Assoc. Res. Foundation, Denver, Colo., 1987, pp. 815. All of these references are herein incorporated by reference in their entirety.
The choice of a carrier to be used is basically determined by the way the composition is to be introduced into the oral cavity. If a toothpaste (including tooth gels, etc.) is to be used, then a �toothpaste carrier� is chosen as disclosed in, e.g., U.S. Pat. No. 3,988,433, to Benedict, the disclosure of which is incorporated herein by reference (e.g., abrasive materials, sudsing agents, binders, humectants, flavoring and sweetening agents, etc.). If a mouth rinse is to be used, then a �mouth rinse carrier� is chosen, as disclosed in, e.g., U.S. Pat. No. 3,988,433 to Benedict (e.g., water, flavoring and sweetening agents, etc.). Similarly, if a mouth spray is to be used, then a �mouth spray carrier� is chosen or if a lozenge is to be used, then a �lozenge carrier� is chosen (e.g., a candy base), candy bases being disclosed in, e.g., U.S. Pat. No. 4,083,955, to Grabenstetter et al., which is incorporated herein by reference; if a chewing gum is to be used, then a �chewing gum carrier� is chosen, as disclosed in, e.g., U.S. Pat. No. 4,083,955, to Grabenstetter et al., which is incorporated herein by reference (e.g., gum base, flavoring and sweetening agents). If a sachet is to be used, then a �sachet carrier� is chosen (e.g., sachet bag, flavoring and sweetening agents). If a subgingival gel is to be used (for delivery of actives into the periodontal pockets or around the periodontal pockets), then a �subgingival gel carrier� is chosen as disclosed in, e.g. U.S. Pat. No. 5,198,220, Damani, issued Mar. 30, 1993, P&G, U.S. Pat. No. 5,242,910, Damani, issued Sept. 7, 1993, P&G, all of which are incorporated herein by reference. Carriers suitable for the preparation of compositions of the present invention are well known in the art. Their selection will depend on secondary considerations like taste, cost, and shelf stability, etc.
The term �lozenge� as used herein includes: breath mints, troches, pastilles, microcapsules, and fast-dissolving solid forms including freeze dried forms (cakes, wafers, thin films, tablets) and fast-dissolving solid forms including compressed tablets. The term �fast-dissolving solid form� as used herein means that the solid dosage form dissolves in less than about 60 seconds, preferably less than about 15 seconds, more preferably less than about 5 seconds, after placing the solid dosage form in the oral cavity. Fast-dissolving solid forms are disclosed in copending U.S. patent application Ser. No. 08/253,890, filed Jun. 3, 1994, Brideau; U.S. Pat. Nos. 4,642,903; 4,946,684; 4,305,502; 4,371,516; 5,188,825; 5,215,756; 5,298,261; 3,882, 228; 4,687,662; 4,642,903. All of these patents are incorporated herein by reference in their entirety.
Abrasives Dental abrasives useful in the topical, oral carriers of the compositions of the subject invention include many different materials. The material selected must be one which is compatible within the composition of interest and does not excessively abrade dentin. Suitable abrasives include, for example, silicas including gels and precipitates, insoluble sodium polymetaphosphate, hydrated alumina, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, and resinous abrasive materials such as particulate condensation products of urea and formaldehyde.
Sudsing Agents (Surfactants) Suitable sudsing agents are those which are reasonably stable and form foam throughout a wide pH range. Sudsing agents include nonionic, anionic, amphoteric, cationic, zwitterionic, synthetic detergents, and mixtures thereof. Many suitable nonionic and amphoteric surfactants are disclosed by U.S. Pat. No. 3,988,433 to Benedict; U.S. Pat. No. 4,051,234, issued Sep. 27, 1977, and many suitable nonionic surfactants are disclosed by Agricola et al., U.S. Pat. No. 3,959,458, issued May 25, 1976, both incorporated herein in their entirety by reference.
Fluoride Ions The present invention may also incorporate free fluoride ions. Preferred free fluoride ions can be provided by sodium fluoride, stannous fluoride, indium fluoride, and sodium monofluorophosphate. Sodium fluoride is the most preferred free fluoride ion. Norris et al., U.S. Pat. No. 2,946,725, issued Jul. 26, 1960, and Widder et al., U.S. Pat. No. 3,678,154 issued Jul. 18, 1972, disclose such salts as well as others. These patents are incorporated herein by reference in their entirety.
Thickening Agents In preparing toothpaste or gels, it is necessary to add some thickening material to provide a desirable consistency of the composition, to provide desirable chlorite release characteristics upon use, to provide shelf stability, and to provide stability of the composition, etc. Preferred thickening agents are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose, laponite and water soluble salts of cellulose ethers such as sodium carboxymethylcellulose and sodium carboxymethyl hydroxyethyl cellulose. Natural gums such as gum karaya, xanthan gum, gum arabic, and gum tragacanth can also be used. Colloidal magnesium aluminum silicate or finely divided silica can be used as part of the thickening agent to further improve texture.
Humectants Another optional component of the topical, oral carriers of the compositions of the subject invention is a humectant. The humectant serves to keep toothpaste compositions from hardening upon exposure to air, to give compositions a moist feel to the mouth, and, for particular humectants, to impart desirable sweetness of flavor to toothpaste compositions. The humectant, on a pure humectant basis, generally comprises from about 0% to about 70%, preferably from about 5% to about 25%, by weight of the compositions herein. Suitable humectants for use in compositions of the subject invention include edible polyhydric alcohols such as glycerin, sorbitol, xylitol, butylene glycol, polyethylene glycol, and propylene glycol, especially sorbitol and glycerin.
Flavoring and Sweetening Agents Flavoring agents can also be added to the compositions. Suitable flavoring agents include oil of wintergreen, oil of peppermint, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, thymol, linalool, cinnamaldehyde glycerol acetal known as CGA, and mixtures thereof. Flavoring agents are generally used in the compositions at levels of from about 0.001% to about 5%, by weight of the composition.
Anticalculus Agent The present invention also includes an anticalculus agent, preferably a pyrophosphate ion source which is from a pyrophosphate salt. The pyrophosphate salts useful in the present compositions include the dialkali metal pyrophosphate salts, tetraalkali metal pyrophosphate salts, and mixtures thereof Disodium dihydrogen pyrophosphate (Na2H2P2O7), tetrasodium pyrophosphate (Na4P2O7), and tetrapotassium pyrophosphate (K4P2O7) in their unhydrated as well as hydrated forms are the preferred species. In compositions of the present invention, the pyrophosphate salt may be present in one of three ways: predominately dissolved, predominately undissolved, or a mixture of dissolved and undissolved pyrophosphate.
Optional agents to be used in place of or in combination with the 4. pyrophosphate salt include such known materials as synthetic anionic polymers, including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described, for example, in U.S. Pat. No. 4,627,977, to Gaffar et al., the disclosure of which is incorporated herein by reference in its entirety; as well as, e.g., polyamino propoane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (e.g., tripolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
Alkali Metal Bicarbonate Salt The present invention may also include an alkali metal bicarbonate salt. Alkali metal bicarbonate salts are soluble in water and unless stabilized, tend to release carbon dioxide in an aqueous system. Sodium bicarbonate, also known as baking soda, is the preferred alkali metal bicarbonate salt. The present composition may contain from about 0.5% to about 30%, preferably from about 0.5% to about 15%, and most preferably from about 0.5% to about 5% of an alkali metal bicarbonate salt.
Miscellaneous Carriers Water employed in the preparation of commercially suitable oral compositions should preferably be of low ion content and free of organic impurities. Water generally comprises from about 5% to about 70%, and preferably from about 20% to about 50%, by weight of the composition herein. These amounts of water include the free water which is added plus that which is introduced with other materials, such as with sorbitol.
Antimicrobial antiplaque agents can also by optionally present in oral compositions. Such agents may include, but are not limited to, triclosan, 5-chloro-2-(2,4-dichlorophenoxy)-phenol, as described in The Merck Index, 11th ed. (1989), pp. 1529 (entry no. 9573) in U.S. Pat. No. 3,506,720, and in European Patent Application No. 0,251,591 of Beecham Group, PLC, published Jan. 7, 1988; chlorhexidine (Merck Index, no. 2090), alexidine (Merck Index, no. 222; hexetidine (Merck Index, no. 4624); sanguinarine (Merck Index, no. 8320); benzalkonium chloride (Merck Index, no. 1066); salicylanilide (Merck Index, no. 8299); domiphen bromide (Merck Index, no. 3411); cetylpyridinium chloride (CPC) (Merck Index, no. 2024; tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol, octapinol, and other piperidino derivatives; nicin preparations; zinc/stannous ion agents; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole; and analogs and salts of the above antimicrobial antiplaque agents. If present, the antimicrobial antiplaque agents generally comprise from about 0.1 % to about 5% by weight of the compositions of the present invention.
For the method of treating diseases or conditions of the oral cavity, including breath malodor (as well as long lasting breath protection), of the present invention, a safe and effective amount of chlorite ion is preferably applied to the gingival/mucosal tissue and/or the teeth (for example, by rinsing with a mouthrinse, directly applying a non-abrasive gel with or without a device, applying a dentifrice or a tooth gel with a toothbrush, sucking or chewing a lozenge or breathmint, etc.) preferably for at least about 10 seconds, preferably from about 20 seconds to about 10 minutes, more preferably from about 30 seconds to about 60 seconds. The method often involves expectoration of most of the composition following such contact. The frequency of such contact is preferably from about once per week to about four times per day, more preferably from about thrice per week to about three times per day, even more preferably from about once per day to about twice per day. The period of such treatment typically ranges from about one day to a lifetime. For particular oral care diseases or conditions the duration of treatment depends on the severity of the oral disease or condition being treated, the particular delivery form utilized and the patient's response to treatment. If delivery to the periodontal pockets is desirable, such as with the treatment of periodontal disease, a mouthrinse can be delivered to the periodontal pocket using a syringe or water injection device. These devices are known to one skilled in the art. Devices of this type include �Water Pik� by Teledyne Corporation. After irrigating, the subject can swish the rinse in the mouth to also cover the dorsal tongue and other gingival and mucosal surfaces. In addition a toothpaste, non-abrasive gel, toothgel, etc. can be brushed onto the tongue surface and other gingival and mucosal tissues of the oral cavity.
EXAMPLES The following examples are made by conventional processes by mixing the following:
Example 1�Dual Phase Dentifrice Dentifrice Phase
20.680 Sodium
18.534 Chlorite (80%)
83.14 Sodium Carbonate
30.00 Xanthan Gum
100.00 Total
100.00 After phases mixed in a 1:1 vol./vol. Ratio, pH approximately 8.5 to 9. 1Grade 7M85F from Aqualon. 2Available from B. F. Goodrich. Example 2�Dual Phase Dentifrice Dentifrice Phase
22.180 Sodium
13.534 Chlorite (80%)
91.07 Disodium Phosphate
Chloride phase
100.00 After phases mixed in a 1:1 vol./vol. Ratio, pH approximately 7.5. 1Grade 7M8SF from Aqualon. 2Available from B. F. Goodrich. Example 3�Single Phase Dentifrice Ingredient
62.277 Sodium Chlorite
25.000 Xanthan Gum
100.00 1Available from B. F. Goodrich. pH approximately 10. Example 4�Dual Phase Mouthwash Mouthwash Phase
45.00 Sodium
19.24 Chlorite (80%)
98.80 Poloxamer 407
33.00 pH = 10
100.00 Example 5�Single Phase Mouthwash Ingredient
98.80 Sodium Chlorite
100.00 Example 6�Chlorite Lozenge Ingredient
mg. Per lozenge
Spray Dried Ethanol1 85.38 Sodium Bicarbonate
100.00 130% load, available from Takasago. Example 8 Dry Powder Mouthrinse for Reconstitution
Spray Dried Ethanol1 75.00 Sodium Bicarbonate
15.72 Sodium Chlorite (80%)
100.00 130% load, available from Takasago. Add dry ingredients, listed above, in any order, and mix until achieving a homogeneous mixture. Colorants, to provide color after adding water to the dry mixture, are optional.
(approx. sufficient
to get pH 10)
1Available from B. F. Goodrich. Example 10 Non-Abrasive Gel
1Available from B. F. Goodrich. For Examples 9 and 10, disperse the Carbopol in water. Thereafter, add the sodium hydroxide and mix. Then add the sodium bicarbonate and mix. Check the pH and adjust to pH of 10 with sodium hydroxide, if needed. Finally, add the sodium chlorite and mix.
Citations de brevets Brevet cit� Date de d�p�t Date de publication D�posant TitreUS327124229 mars 19636 sept. 1966Alexander C. PolitisStable chlorine dioxide composition and method of making sameUS32784472 d�c. 196311 oct. 1966Cloro-Bac Products, Inc.Process for stabilizing chlorine dioxide solutionUS406060026 oct. 197229 nov. 1977National Patent Development CorporationTreating teethUS408474726 mars 197618 avr. 1978Alliger; HowardGerm killing composition and methodUS433053120 juin 198018 mai 1982Alliger; HowardGerm-killing materialsUS45740842 f�vr. 19844 mars 1986Berger; PeterProcess for the preparation of a modified aqueous chlorite solution, the solution prepared by this process and the use thereofUS458548225 mai 198429 avr. 1986Southern Research InstituteLong-acting biocidal compositions and method thereforUS45924873 juil. 19853 juin 1986Simon; Gilbert I.DentifricesUS468921529 d�c. 198625 ao�t 1987Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS469681129 d�c. 198629 sept. 1987Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS478649222 juil. 198722 nov. 1988Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS478805322 juil. 198729 nov. 1988Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS479244222 juil. 198720 d�c. 1988Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS479398922 juil. 198727 d�c. 1988Ratcliff; Perry A.Method and composition for prevention and treatment of oral diseaseUS480838922 juil. 198728 f�vr. 1989Ratcliffe; Perry A.Method and composition for prevention and treatment of oral diseaseUS481851924 ao�t 19874 avr. 1989Ratcliff; Perry A.Method and composition for prevention of plaque formation and plaque dependent diseasesUS482912929 mai 19879 mai 1989International Dioxcide, Inc.Reaction product of polymer with chlorine dioxideUS483700910 mars 19876 juin 1989Ractliff; Perry A.Method and composition for prevention of plaque formation and plaque dependent diseasesUS485121314 sept. 198825 juil. 1989Ratcliff; Perry A.Method and composition for prevention and treatment of oral disease due to S. SanguisUS48551358 d�c. 19888 ao�t 1989Ratcliff; Perry A.Method for debridingUS488063823 ao�t 198814 nov. 1989Bioxy International, Ltd.Biocidal composition and method for disinfecting articlesUS48866572 d�c. 198812 d�c. 1989Ratcliff; Perry A.Method for preventing periodontitisUS48897142 d�c. 198826 d�c. 1989Ratcliff; Perry A.Method for retarding dental plaque by killing streptococcus sanguisUS489121614 avr. 19872 janv. 1990Alcide CorporationDisinfecting compositions and methods thereforUS4902498 *1 juin 198820 f�vr. 1990The Procter & Gamble CompanyOral compositionsUS49256562 d�c. 198815 mai 1990Ratcliff; Perry A.Method for retarding formation of dental plaqueUS49752852 juin 19894 d�c. 1990Ratcliff; Perry A.Method for cleaning dental prosthetic devicesUS49785354 oct. 198818 d�c. 1990Ratcliff; Perry A.Method for cleaning contact lensesUS498699011 oct. 198922 janv. 1991Alcide CorporationDisinfection method and composition thereforUS501940220 f�vr. 199028 mai 1991Alcide CorporationComposition and procedure for disinfecting blood and blood componentsUS50525909 mai 19901 oct. 1991Ratcliff; Perry A.Resealable dual compartment containerUS5100652 *28 f�vr. 199031 mars 1992Alcide CorporationDisinfecting oral hygiene compositions and process for using the sameUS518516127 nov. 19909 f�vr. 1993Alcide CorporationDisinfection method and composition thereforUS520017120 nov. 19906 avr. 1993Micropure, Inc.Oral health preparation and methodUS5281412 *12 mars 199325 janv. 1994The Procter & Gamble CompanyOral compositionsUS534873428 janv. 199320 sept. 1994Micropure Inc.Oral health preparation and methodUS54894356 juil. 19936 f�vr. 1996Ratcliff; Perry A.Composition for treatment of abnormal conditions of the epithelium of bodily orificesUS561855019 mai 19958 avr. 1997Rbr HoldingsMethod for treatment of abnormal conditions of the epithelium of bodily orificesUS56313005 juin 199520 mai 1997Southwest Research InstituteMethod of making a sustained release biocidal compositionUS56504465 juin 199522 juil. 1997Southwest Research InstituteSustained release biocidal compositionUS5738840 *14 f�vr. 199714 avr. 1998Profresh Properties, Inc.Oral rinse and method of treating halitosisUS5753217 *14 ao�t 199619 mai 1998William C. ChristopfelMethod of reducing oral malodorUS57729868 avr. 199630 juin 1998Kross; Robert D.Compositions and methods for reducing oral malodorUS582082225 oct. 199613 oct. 1998Kross; Robert D.Antimicrobial composition and method of useUS5944528 *28 juil. 199731 ao�t 1999Idex Dental Sciences, Inc.Chlorine dioxide tooth whitening compositionsUS6077502 *27 f�vr. 199820 juin 2000The Procter & Gamble CompanyOral care compositions comprising chlorite and methodsUS6132702 *27 f�vr. 199817 oct. 2000The Procter & Gamble CompanyOral care compositions comprising chlorite and methodsDE2329753A112 juin 197313 d�c. 1973National Patent Development Corp., New York, N.Y. (V.St.A.)Mittel zur mund- und zahnpflegeEP0287074A213 avr. 198819 oct. 1988Alcide CorporationDisinfecting compositionsEP0344701B1 *30 mai 198914 d�c. 1994THE PROCTER &amp; GAMBLE COMPANYOral compositionsEP0565134A113 avr. 198813 oct. 1993Alcide CorporationDisinfecting compositions and methods thereforGB2289841A Titre non disponibleGB2290233A Titre non disponibleJP2104509A Titre non disponibleJP9183706A Titre non disponibleJP60054311A Titre non disponibleJP60105610A Titre non disponibleWO1989003179A111 oct. 198820 avr. 1989New Generation Products, Inc.Chlorine dioxide germicidal compositionWO1993018781A119 mars 199330 sept. 1993Alcide CorporationChlorine dioxide containing composition for prevention and treatment of bacterial infectionsWO1995027472A13 avr. 199519 oct. 1995Jon L. RichterOral rinse and method of treating halitosisWO1996025916A123 f�vr. 199629 ao�t 1996Diamond White A.V.V.Method for preparing a preparation for bleaching teeth or for treating skin complaints and mucous membrane disordersWO1997007777A1 *15 ao�t 19966 mars 1997Robert Eric MontgomeryPeroxidase-activating oral compositionsWO1998004235A128 juil. 19975 f�vr. 1998Robert Eric MontgomeryChlorine dioxide tooth whitening compositionsWO1998017195A1 *23 oct. 199730 avr. 1998Milroy CodipillyCOMPOSITIONS TO CONTROL ORAL MICROBIAL OXIDATION-REDUCTION (Eh) LEVELSWO1999034773A1 *5 janv. 199915 juil. 1999Satyanarayana MajetiAntimicrobial peroxy acid oral care compositions and methodsWO1999043290A1 *26 f�vr. 19992 sept. 1999The Procter & Gamble CompanyOral care compositions comprising chlorite and methodsWO1999043294A1 *26 f�vr. 19992 sept. 1999Procter & GambleOral care compositions comprising chlorite and methodsWO1999043295A1 *26 f�vr. 19992 sept. 1999The Procter & Gamble CompanyOral care compositions comprising chlorite* Cit� par l'examinateurCitations hors brevetsR�f�rence1Richter, "Diagnosis and Treatment of Halitosis", Compendium, vol. 17, No. 4, pp. 370-384 (1996).2U. S. application No. 09/032,234, Witt et al., Feb. 27, 1998.3U. S. application No. 09/032,237, Witt et al., Feb. 27, 1998.4U. S. application No. 09/032,238, Witt et al., Feb. 27, 1998.5U. S. application No. 09/487,692, Witt et al., Jan. 19, 2000.6White et al., "Chemistry of Chlorites", Industrial and Engineering Chemistry, vol. 34, No. 7, pp. 782-792 (1942).7Yates et al., "The Comparative Effect of Acidified Sodium Chlorite and Chlorhexidine Mouthrinses on Plaque Regrowth and Salivary Bacterial Counts", J. Clin. Periodontol, vol. 24, pp. 603-609 (1997). R�f�renc� par Brevet citant Date de d�p�t Date de publication D�posant TitreUS6350438 *30 juin 200026 f�vr. 2002The Procter & Gamble CompanyOral care compositions comprising chlorite and methodsUS6696047 *14 ao�t 200224 f�vr. 2004The Procter & Gamble CompanyStable oral care compositions comprising chloriteUS6846478 *30 juin 200025 janv. 2005The Procter & Gamble CompanyPromoting whole body healthUS754420425 f�vr. 20059 juin 2009Valam CorporationControl of halitosis-generating and other microorganisms in the non-dental upper respiratory tract* Cit� par l'examinateurClassifications Classification aux �tats-Unis424/48, 424/440, 424/53 Classification internationaleA61K33/20, A61K8/20, A61K9/20, A61K8/19, A61Q11/00 Classification coop�rativeA61K33/20, A61K8/20, A61Q11/00 Classification europ�enneA61K8/20, A61Q11/00, A61K33/20Faire pivoterImage d'origineAccueil Google - Plan du site - T�l�chargements par lot sur l'USPTO - R�gles de confidentialit� - Conditions d'utilisation - � propos de Google�Brevets - Envoyer des commentairesDonn�es fournies par IFI CLAIMS Patent Services©2012 Google