Source: http://www.google.com/patents/US7008368?dq=6377161
Timestamp: 2016-07-25 17:59:33
Document Index: 717099242

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 30822']

Patent US7008368 - Method for making treatment strands - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of tubular shaped, hollow radioactive seeds with a bore. The seed strand as assembled with a material provided in the bore and between the spaced seeds is axially stiff and radially flexible and...http://www.google.com/patents/US7008368?utm_source=gb-gplus-sharePatent US7008368 - Method for making treatment strandsAdvanced Patent SearchPublication numberUS7008368 B2Publication typeGrantApplication numberUS 10/716,328Publication dateMar 7, 2006Filing dateNov 18, 2003Priority dateNov 2, 2001Fee statusLapsedAlso published asUS6786858, US7252630, US20030088144, US20040102672, US20070135674, WO2003039463A2, WO2003039463A3Publication number10716328, 716328, US 7008368 B2, US 7008368B2, US-B2-7008368, US7008368 B2, US7008368B2InventorsRichard A. Terwilliger, Gary A. LamoureuxOriginal AssigneeIdeamatrix, Inc., Worldwide Medical Technologies, LlcExport CitationBiBTeX, EndNote, RefManPatent Citations (76), Non-Patent Citations (10), Referenced by (5), Classifications (19), Legal Events (8) External Links: USPTO, USPTO Assignment, EspacenetMethod for making treatment strands
US 7008368 B2Abstract
A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of tubular shaped, hollow radioactive seeds with a bore. The seed strand as assembled with a material provided in the bore and between the spaced seeds is axially stiff and radially flexible and is bioabsorbable in living tissue.
This application is a divisional application of, and claims priority to U.S. patent application Ser. No. 10/132,930, filed Apr. 26, 2002, now a Pat. No. 6,786,858 B2, which claims priority to U.S. Provisional Patent Application No. 60/336,329, filed Nov. 2, 2001; and U.S. Provisional Patent Application No. 60/360,260 filed Feb. 26, 2002, all of which are incorporated herein by reference.
U.S. patent application Ser. No. 10/035,083 entitled “Delivery System and Method for Interstitial Radiation Therapy,” by Terwilliger, et al., filed Dec. 28, 2001.
U.S. Patent Application No. 60/360,241 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Strands Constructed With Preformed Strand Housing,” by Terwilliger et al., filed Feb. 26, 2002.
U.S. Patent Application No. 60/360,237 entitled “System for Manufacturing Interstitial Radiation Therapy Seed Strands,” by Terwilliger et al., filed Feb. 26, 2002.
U.S. Patent Application No. 60/360,272 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Strands Constructed With Extruded Strand Housing,” by Terwilliger et al., filed Feb. 26, 2002.
U.S. patent application Ser. No. 10/162,548 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Strand Constructed with Preformed Strand Housing” by Terwilliger et al., filed Jun. 4, 2002.
U.S. patent application Ser. No. 10/162,546 entitled “System for Manufacturing Interstitial Radiation Therapy Seed Strand” by Terwillier et al., filed Jun. 4, 2002.
U.S. patent application Ser. No. 10/162,006 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Strands Constructed with Extruded Strand Housings” by Terwillier et al., filed Jun. 4, 2002.
U.S. patent application Ser. No. 10/397,940 entitled “Delivery System and Method for Interstitial Radiation Therapy” by Terwillier et al., filed Mar. 26, 2003.
U.S. Patent Application No. 60/469,940 entitled “Delivery System and Method for Interstitial Radiation Therapy using Seed Strands with Custom End Spacing” by Terwilliger et al., filed May 13, 2003.
U.S. patent application Ser. No. 10/619,928 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Strands with Custom End Spacings” by Terwilliger et al., filed Jul. 15, 2003.
U.S. patent application Ser. No. 10/705,133 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Strands Constructed with Preformed Strand Housing” By Terwilliger et al., filed Nov. 10, 2003
U.S. Patent Application No. 60/360,299 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Elements With Ends Having One of Projections and Indentations,” by Terwilliger et al., filed Feb. 26, 2002.
U.S. patent application Ser. No. 10/162,547 entitled “Delivery System and Method for Interstitial Radiation Therapy Using Seed Elements with Ends having One of Projections and Indentations” by Terwillier et al., filed Jun. 4, 2002.
While assemblies with bio-absorbable materials and spaced radioactive seeds are known for use as interstitial implants, such assemblies are not entirely satisfactory. In one instance, the elongated implant is made using a bio-absorbable material consisting of an Ethicon Vicryl.RTM. This material is commonly known as PGA. Radioactive seeds and teflon spacers are inserted into the material. Needles loaded with the seeds in the carrier bio-absorbable material are sterilized or autoclaved causing contraction of the carrier material and resulting in a rigid column of seeds and spacers. This technique was reported in “Ultrasonically Guided Transperineal Seed Implantation of the Prostate: Modification of the Technique and Qualitative Assessment of Implants” by Van't Riet, et al., International Journal of Radiation Oncology, Biology and Physics, Vol. 24, No. 3, pp. 555–558, 1992, which is incorporated herein by reference. Such rigid implants have many drawbacks, including not having the ability to flex with the tissue over the time that the bio-absorbable material dissolves.
U.S. Patent Documents: U.S. Pat. No. 1,578,945 issued January 1923 to Withers; U.S. Pat. No. 2,067,589 issued January 1937 to Antrim; and U.S. Pat. No. 3,351,049 issued November 1967 to Lawrence. Publications: Medi-Physics brochure entitled “I-125 Seeds.RTM. In Carrier”, Model No. 6720; Medi-Physics brochure entitled “I-125 Seed.RTM. Source Model 671”; and Martinez et al., Int. J. Radiation Oncology Biol. Phys., Vol. 5, No. 3, March 1979, pp. 411–413. SUMMARY OF SOME OF THE ASPECTS OF THE INVENTION
FIG. 1 is an enlarged side view of a tubular shaped, hollow radioactive seed element with a central bore.
Unlike prior brachytherapy devices, the present invention utilizes a polymer-based suture inserted through the bore of a tubular shaped seed. This device provides for improved brachytherapy because radioactive seeds can be conveniently threaded on to suture material that is readily available in any treatment setting. Suture material, rigid rods or other biocompatible connecting members can be passed through the center of the device and then the position of the seed elements can be fixed as needed for treatment. Heating the polymer strands with the seeds in position will cause the polymer to expand and fix the seeds in position. The polymer can be bioabsorbable. Examples of polymers are shown in Table 1. The hollow tube design of the device permits tissue to grow into the hollow space, particularly after the polymer suture material has been absorbed, further minimizing migration of the seed. The tube shaped substrate can be made of a material that is essentially transparent to radiation, such as titanium. In addition to the radioisotopes listed in Table 1, the seed can be coated with a isotope that will convert to radioactive emissions. The precursor isotope can be activated to varying degrees which would allow customization of the emission given off by a single seed because the amount of irradiation and subsequent activation can be varied for different treatment strategies. The hollow tube-shaped substrate can be formed from a material transparent to radiation emitted by the therapeutic isotope. Covering the radioactive layer with a sealing layer prevents direct contact between the radioactive isotope and health care workers, or its escape into the surrounding environment or tissues.
Additionally, seeds can be manufactured using iridium 192, cesium 131, gold 198, yttrium 90 and phosphorus 32. Further radioactive isotopes used to manufacture seeds are not limited to these examples, but can include other sources of different types of radiation. In addition, it is to be understood that other types of seeds can be used. In particular, seeds such as those described in U.S. Pat. No. 6,248,057, which patent is incorporated herein by reference, and which is entitled “Absorbable Brachytherapy and Chemotherapy Delivery Devices and Methods”, can be used with the present invention. These seeds include radiation delivery devices, drug delivery devices, and combinations of radiation and drug delivery devices in the form of beads, seeds, particles, rods, gels, and the like. These particular seeds are absorbable. In such seeds, the bio-absorbable structure can have a predefined persistence which is substantially longer than a half-life of the radioactive element contained in the bio-absorbable structure. These above bio-absorbable seeds can be used in the same manner as the seeds described herein with respect to the invention.
The substantially axially, semi-rigid, and radially or laterally flexible elongated member may be made of any of the natural and/or synthetic bio-compatible and bio-absorbable materials. Natural and synthetic polymers and copolymers can be used. Examples of synthetic bio-absorbable polymer materials are the polymers and copolymers of glycolide and lactide, polydioxanone and the like. Such polymeric materials are more fully described in U.S. Pat. Nos. 3,565,869, 3,636,956, 4,052,988, and European Patent Application No. 30822, all of which are incorporated herein by reference. Specific examples of bio-absorbable polymeric materials that can be used to produce the substantially axially stiff and radially flexible elongated member of embodiment of the present invention are polymers made by ETHICON, Inc., Somerville, N.J., under the trademarks “MONOCRYL”™ and “MAXON”,™ which material is incorporated herein by reference.
Table 2 below, provides examples of polymers (and manufacturers) suitable for use in producing embodiments of the therapeutic member of the invention. A further discussion of such biodegradable polymers can be found in an article by John C. Middleton and Arthur J. Tipton entitled “Synthetic Biodegradable Polymers as Medical Devices,” published March 1998 in Medical Plastics and Bio-materials, which article is incorporated herein by reference.
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1. The substantially axially stiff and radially flexible elongated member allows controlled placement of the plurality of radioactive seeds that are encapsulated and positioned in a predetermined array along the member without migration of the individual radioactive seeds during the time the seeds are treating the tumor. 2. The fixed linear positioning of the seeds minimizes “hot” and “cold” radiation spots due to undesirable movement of the seeds. 3. The axial stiffness of the elongated member allows the elongated member to be urged out of the needle as the needle is withdrawn, without the member jamming in the needle, by collapsing or expanding as the needle is withdrawn from the tumor site. 4. The radial flexibility of the elongated member allows locational accuracy to be maintained as the gland shrinks to pre-procedural size, as the swelling that occurs during tissue disruption and needle manipulation recedes. 5. Increased speed of implant resulting in reduced surgical time and health care provider radiation exposure. Method of Delivering Customized Strands and/or Members Per A Therapeutic Prescription
As is known in the industry, there is software which can be used to provide branchytherapy treatment planning guides which are customized for each individual patent. Such software is provided by Rossmed which is located at Ross Medical, 7100 Columbia Gateway Drive, Suite 160, Columbia, Md. 21046. This particular software, which is incorporated herein by reference, is known as the Strata suite, which software helps physicians to develop and visualize low dose rate brachytherapy treatment plans for treating malignant tumors in human tissue. The treatments entail the use of radioactive seed sources which are implanted adjacent to the malignant tissue. The Strata software uses imaging to create a three dimensional reconstruction of the patient's anatomy. The software is able to plan the placement of the seeds within the target. The radiation dose that is delivered to the target can be computerized and visualized using the software. The software can then specify an optimal number of strands or members along with optimal seed dosages and spaces between seeds. At times, the loading plans so specified cannot be optimized by the physician in preparing the seed and spacer loads for the needles, as the spacers come in only predefined lengths.
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Bard, Inc.Multi-lumen catheter including a lumen having a variable cross sectional areaUS20100280367 *Apr 21, 2010Nov 4, 2010Ducharme Richard WSystem and method for fiducial deploymentUS20100292682 *May 12, 2010Nov 18, 2010Novian Health, Inc.Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy* Cited by examinerClassifications U.S. Classification600/8International ClassificationA61N5/10, A61M36/00, G21G4/08, A61M36/12, A61N5/00, B29C47/02Cooperative ClassificationY10T29/49, B29C47/021, A61N2005/1023, B29C47/028, A61N5/1007, A61N5/1027, G21G4/08, B29C47/0016European ClassificationA61N5/10B7, B29C47/02E, G21G4/08, A61N5/10B2Legal EventsDateCodeEventDescriptionDec 31, 2003ASAssignmentOwner name: IDEAMATRIX, INC., COLORADOFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TERWILLIGER, RICHARD A.;REEL/FRAME:014227/0296Effective date: 20031209Dec 1, 2005ASAssignmentOwner name: WORLDWIDE MEDICAL TECHNOLOGIES, L.L.C., CONNECTICUFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LAMOUREUX, GARY;REEL/FRAME:017073/0913Effective date: 20051028Aug 8, 2008ASAssignmentOwner name: BIOCOMPATIBLES UK LIMITED, UNITED KINGDOMFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:WORLD WIDE MEDICAL TECHNOLOGIES, LLC;REEL/FRAME:021354/0292Effective date: 20080801Owner name: BIOCOMPATIBLES UK LIMITED,UNITED KINGDOMFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:WORLD WIDE MEDICAL TECHNOLOGIES, LLC;REEL/FRAME:021354/0292Effective date: 20080801Jul 15, 2009ASAssignmentOwner name: WORLD WIDE MEDICAL OF FLORIDA, LLC, CONNECTICUTFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:IDEAMATRIX, INC.;REEL/FRAME:022960/0112Effective date: 20090610Owner name: WORLD WIDE MEDICAL OF FLORIDA, LLC,CONNECTICUTFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:IDEAMATRIX, INC.;REEL/FRAME:022960/0112Effective date: 20090610Jul 17, 2009ASAssignmentOwner name: BIOCOMPATIBLES UK LIMITED, UNITED KINGDOMFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:WORLD WIDE MEDICAL OF FLORIDA, LLC;REEL/FRAME:022960/0970Effective date: 20090709Owner name: BIOCOMPATIBLES UK LIMITED,UNITED KINGDOMFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:WORLD WIDE MEDICAL OF FLORIDA, LLC;REEL/FRAME:022960/0970Effective date: 20090709Oct 12, 2009REMIMaintenance fee reminder mailedMar 7, 2010LAPSLapse for failure to pay maintenance feesApr 27, 2010FPExpired due to failure to pay maintenance feeEffective date: 20100307RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services