Source: http://www.google.com/patents/US20070244546?dq=6,967,448
Timestamp: 2016-09-29 02:07:28
Document Index: 496428961

Matched Legal Cases: ['art 100', 'art 100', 'art 100', 'art 100', 'art 100', 'art 100']

Patent US20070244546 - Stent Foundation for Placement of a Stented Valve - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA valve replacement system that can be used for treating abnormalities of the right ventricular outflow tract in a nonsymmetrical region of a vessel or conduit that includes a prosthetic valve device and a foundation structure. The foundation structure contacts a portion of the inner wall of a vessel...http://www.google.com/patents/US20070244546?utm_source=gb-gplus-sharePatent US20070244546 - Stent Foundation for Placement of a Stented ValveAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20070244546 A1Publication typeApplicationApplication numberUS 11/379,105Publication dateOct 18, 2007Filing dateApr 18, 2006Priority dateApr 18, 2006Publication number11379105, 379105, US 2007/0244546 A1, US 2007/244546 A1, US 20070244546 A1, US 20070244546A1, US 2007244546 A1, US 2007244546A1, US-A1-20070244546, US-A1-2007244546, US2007/0244546A1, US2007/244546A1, US20070244546 A1, US20070244546A1, US2007244546 A1, US2007244546A1InventorsRichard FrancisOriginal AssigneeMedtronic Vascular, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (99), Referenced by (130), Classifications (12), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetStent Foundation for Placement of a Stented Valve
TECHNICAL FIELD [0001] This invention relates generally to medical devices for treating cardiac valve abnormalities, and particularly to a pulmonary valve replacement system and method of employing the same. BACKGROUND OF THE INVENTION [0002] Heart valves, such as the mitral, tricuspid, aortic and pulmonary valves, are sometimes damaged by disease or by aging, resulting in problems with the proper functioning of the valve. Heart valve problems generally take one of two forms: stenosis, in which a valve does not open completely or the opening is too small, resulting in restricted blood flow; or insufficiency, in which blood leaks backward across a valve when it should be closed. [0003] The pulmonary valve regulates blood flow between the right ventricle and the pulmonary artery, controlling blood flow between the heart and the lungs. Pulmonary valve stenosis is frequently due to a narrowing of the pulmonary valve or the pulmonary artery distal to the valve. This narrowing causes the right side of the heart to exert more pressure to provide sufficient flow to the lungs. Over time, the right ventricle enlarges, which leads to congestive heart failure (CHF). In severe cases, the CHF results in clinical symptoms including shortness of breath, fatigue, chest pain, fainting, heart murmur, and in babies, poor weight gain. Pulmonary valve stenosis most commonly results from a congenital defect, and is present at birth, but is also associated with rheumatic fever, endocarditis, and other conditions that cause damage to or scarring of the pulmonary valve. Valve replacement may be required in severe cases to restore cardiac function. [0004] Previously, valve repair or replacement required open-heart surgery with its attendant risks, expense, and extended recovery time. Open-heart surgery also requires cardiopulmonary bypass with risk of thrombosis, stroke, and infarction. More recently, flexible valve prostheses and various delivery devices have been developed so that replacement valves can be implanted transvenously using minimally invasive techniques. As a consequence, replacement of the pulmonary valve has become a treatment option for pulmonary valve stenosis. [0005] The most severe consequences of pulmonary valve stenosis occur in infants and young children when the condition results from a congenital defect. Frequently, the pulmonary valve must be replaced with a prosthetic valve when the child is young, usually less than five years of age. However, as the child grows, the valve can become too small to accommodate the blood flow to the lungs that is needed to meet the increasing energy demands of the growing child, and it may then need to be replaced with a larger valve. Alternatively, in a patient of any age, the implanted valve may fail to function properly due to calcium buildup and have to be replaced. In either case, repeated surgical or transvenous procedures are required. [0006] To address the need for pulmonary valve replacement, various implantable pulmonary valve prostheses, delivery devices and surgical techniques have been developed and are presently in use. One such prosthesis is a bioprosthetic, valved conduit comprising a glutaraldehyde treated bovine jugular vein containing a natural, trileaflet venous valve, and sinus. A similar device is composed of a porcine aortic valve sutured into the center of a woven fabric conduit. A common conduit used in valve replacement procedures is a homograft, which is a vessel harvested from a cadaver. Valve replacement using either of these devices requires thoracotomy and cardiopulmonary bypass. [0007] When the valve in the prostheses must be replaced, for the reasons described above or other reasons, an additional surgery is required. Because many patients undergo their first procedure at a very young age, they often undergo numerous procedures by the time they reach adulthood. These surgical replacement procedures are physically and emotionally taxing, and a number of patients choose to forgo further procedures after they are old enough to make their own medical decisions. [0008] Recently, implantable stented valves have been developed that can be delivered transvenously using a catheter-based delivery system. These stented valves comprise a collapsible valve attached to the interior of a tubular frame or stent. The valve can be any of the valve prostheses described above, or it can be any other suitable valve. In the case of valves in harvested vessels, the vessel can be of sufficient length to extend beyond both sides of the valve such that it extends to both ends of the valve support stent. [0009] The stented valves can also comprise a tubular portion or “stent graft” that can be attached to the interior or exterior of the stent to provide a generally tubular internal passage for the flow of blood when the leaflets are open. The graft can be separate from the valve and it can be made from any suitable biocompatible material including, but not limited to, fabric, a homograft, porcine vessels, bovine vessels, and equine vessels. [0010] The stent portion of the device can be reduced in diameter, mounted on a catheter, and advanced through the circulatory system of the patient. The stent portion can be either self-expanding or balloon expandable. In either case, the stented valve can be positioned at the delivery site, where the stent portion is expanded against the wall of a previously implanted prostheses or a native vessel to hold the valve firmly in place. [0011] One embodiment of a stented valve is disclosed in U.S. Pat. No. 5,957,949 titled “Percutaneous Placement Valve Stent” to Leonhardt, et al, the contents of which are incorporated herein by reference. [0012] Over time, implanted prosthetic conduits and valves are frequently subject to calcification, causing the affected conduit or valve to lose flexibility, become misshapen, and fail to function effectively. Furthermore, because they are long term implants, synthetic conduits sometimes undergo longitudinal stretching or fibrotic ingrowth of the tissue surrounding the conduit. In either case, the conduit can become so distorted that blood flow is impeded or the valve is misaligned and fails to function optimally because it is no longer perpendicular to the flow of blood through the conduit. [0013] An additional drawback of using a stented valve is that the stents are often difficult to properly position within a conduit resulting in a misplaced valve. Additionally, stented valves may migrate along the conduit after implantation due to forces applied by the blood flow through the vessel. [0014] It would be desirable, therefore, to provide an implantable pulmonary valve that can readily be replaced, and that would overcome the limitations and disadvantages inherent in the devices described above. SUMMARY OF THE INVENTION [0015] It is an object of the present invention to provide a vascular valve replacement system for replacing valves in previously implanted valved conduits, where at least a portion of the conduit has become non-symmetrical after the conduit was implanted. The valve replacement system of the current invention has at least a delivery catheter and a replacement valve device disposed on the delivery catheter. The replacement valve device includes a prosthetic valve connected to a valve support region of an expandable support structure. The valve support region includes a plurality of protective struts disposed between a first stent region and a second stent region. [0016] The system and the prosthetic valve will be described herein as being used for replacing a pulmonary valve. The pulmonary valve is also known to those having skill in the art as the “pulmonic valve” and as used herein, those terms shall be considered to mean the same thing. [0017] Thus, one aspect of the present invention provides a system for treating abnormalities of the right ventricular outflow tract comprising a conduit having a nonsymmetrical lumen, a delivery catheter, a foundation structure, and a prosthetic valve device. The prosthetic valve device comprises a valve connected to a stent. When the foundation structure and the valve device are deployed from the catheter and positioned within the lumen of the conduit, the support structure provides a symmetrical region within the lumen of the conduit that is complementary to the exterior surface of the prosthetic valve device and thereby improves the functioning of the valve. [0018] Another aspect of the invention provides a pulmonary valve replacement system for use in a conduit with a nonsymmetrical lumen. The system includes a foundation structure and a prosthetic valve device. When the foundation structure is positioned within a nonsymmetrical region of the conduit, the foundation structure expands causing a region of the lumen of the conduit to undergo a corresponding shape change. As a result, the affected region of the lumen of the conduit becomes round and symmetrical, and is complementary to the exterior surface of the prosthetic valve device. [0019] Another aspect of the invention provides a method for replacing a pulmonary valve. The method comprises using a catheter to deliver a foundation structure and a pulmonary valve device to a treatment site within the lumen of a conduit. The method further comprises deploying the foundation structure from the catheter within a nonsymmetrical region of the lumen of the conduit. The foundation structure expands and causes a symmetrical region to be formed within the lumen of the conduit. The method further comprises deploying the valve device from the catheter, positioning the valve device within the symmetrical region of the lumen of the conduit. [0020] The present invention is illustrated by the accompanying drawings of various embodiments and the detailed description given below. The drawings should not be taken to limit the invention to the specific embodiments, but are for explanation and understanding. The detailed description and drawings are merely illustrative of the invention rather than limiting, the scope of the invention being defined by the appended claims and equivalents thereof. The drawings are not to scale. The foregoing aspects and other attendant advantages of the present invention will become more readily appreciated by the detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS [0021] FIG. 1 is a schematic interior view of a human heart showing the functioning of the four heart valves; [0022] FIG. 2A is a schematic view showing the placement of a pulmonary conduit, as is known in the prior art; [0023] FIG. 2B is a schematic view showing attachment of a pulmonary conduit to the pulmonary artery, as is known in the prior art; [0024] FIG. 2C is a schematic view showing attachment of a pulmonary conduit to the heart, as is known in the prior art; [0025] FIG. 3 is a schematic view of a delivery catheter with foundation structure and a stented valve device positioned in a nonsymmetrical region of a conduit, in accordance with the present invention; [0026] FIG. 4 is a schematic view of a foundation structure forming a symmetrical fluid passageway complementary to the exterior surface of the stented valve at the treatment site within the lumen of a conduit, in accordance with the present invention; [0027] FIG. 5A is a schematic diagram of a foundation structure having a bracket for holding the valve device in a fixed position, in accordance with the present invention; [0028] FIG. 6A is a schematic diagram of a foundation structure having a holding member on the inner surface of the foundation structure; [0029] FIG. 6B is a cross sectional end view of the foundation structure having a holding member shown in FIG. 6A; [0030] FIG. 7 is a schematic view of a valve support structure in a portion of a conduit that has been restored to a symmetric shape by implanting a tubular scaffold, in accordance with the present invention; and [0031] FIG. 8 is a flow diagram of a method of treating right ventricular outflow tract abnormalities by replacing a pulmonary valve in the lumen of a nonsymmetrical conduit, in accordance with the present invention.
DETAILED DESCRIPTION [0032] The invention will now be described by reference to the drawings wherein like numbers refer to like structures. [0033] Referring to the drawings, FIG. 1 is a schematic representation of the interior of human heart 100. Human heart 100 includes four valves that work in synchrony to control the flow of blood through the heart. Tricuspid valve 104, situated between right atrium 118 and right ventricle 116, and mitral valve 106, between left atrium 120 and left ventricle 114 facilitate filling of ventricles 116 and 114 on the right and left sides, respectively, of heart 100. Aortic valve 108 is situated at the junction between aorta 112 and left ventricle 114 and facilitates blood flow from heart 100, through aorta 112 to the peripheral circulation. [0034] Pulmonary valve 102 is situated at the junction of right ventricle 116 and pulmonary artery 110 and facilitates blood flow from heart 100 through the pulmonary artery 110 to the lungs for oxygenation. The four valves work by opening and closing in harmony with each other. During diastole, tricuspid valve 104 and mitral valve 106 open and allow blood flow into ventricles 114 and 116, and the pulmonic valve and aortic valve are closed. During systole, shown in FIG. 1, aortic valve 108 and pulmonary valve 102 open and allow blood flow from left ventricle 114, and right ventricle 116 into aorta 112 and pulmonary 110, respectively. [0035] The right ventricular outflow tract is the segment of pulmonary artery 110 that includes pulmonary valve 102 and extends to branch point 122, where pulmonary artery 110 forms left and right branches that carry blood to the left and right lungs respectively. A defective pulmonary valve or other abnormalities of the pulmonary artery that impede blood flow from the heart to the lungs sometimes require surgical repair or replacement of the right ventricular outflow tract with prosthetic conduit 202, as shown in FIG. 2A-C. [0036] Such conduits comprise tubular structures of biocompatible materials, with a hemocompatible interior surface. Examples of appropriate biocompatible materials include polytetrafluoroethylene (PTFE), woven polyester fibers such as Dacron� fibers (E.I. Du Pont De Nemours & Co., Inc.), and bovine vein cross-linked with glutaraldehyde. One common conduit is a homograft, which is a vessel harvested from a cadaver and treated for implantation into a recipient's body. These conduits may contain a valve at a fixed position within the interior lumen of the conduit that functions as a replacement pulmonary valve. One such conduit 202 comprises a bovine jugular vein with a trileaflet venous valve preserved in buffered glutaraldehyde. Other valves are made of synthetic materials and are attached to the wall of the lumen of the conduit. The conduits may also include materials having a high X-ray attenuation coefficient (radiopaque materials) that are woven into or otherwise attached to the conduit, so that it can be easily located and identified. [0037] As shown in FIGS. 2A and 2B, conduit 202, which houses valve 204 within its inner lumen, is installed within a patient by sewing the distal end of conduit 202 to pulmonary artery 110, and, as shown in FIG. 2C, attaching the proximal end of conduit 202 to heart 100 so that the lumen of conduit 202 connects to right ventricle 116. [0038] Over time, implanted prosthetic conduits and valves are frequently subject to calcification, causing the affected conduit or valve to lose flexibility, become misshapen, and lose the ability to function effectively. Additional problems are encountered when prosthetic valves are implanted in young children. As the child grows, the valve will ultimately be too small to handle the increased volume of blood flowing from the heart to the lungs. In either case, the valve needs to be replaced. [0039] The current invention discloses devices and methods for percutaneous catheter based placement of stented valves for regulating blood flow through a pulmonary artery. In a preferred embodiment, the valves are attached to an expandable support structure and they are placed in a valved conduit that is been attached to the pulmonary artery, and that is in fluid communication with the right ventricle of a heart. The support structure can be expanded such that any pre-existing valve in the conduit is not disturbed, or it can be expanded such that any pre-existing valve is pinned between the support structure and the interior wall of the conduit. [0040] The delivery catheter carrying the stented valve is passed through the venous system and into a patient's right ventricle. This may be accomplished by inserting the delivery catheter into either the jugular vein or the subclavian vein and passing it through superior vena cava into right atrium. The catheter is then passed through the tricuspid valve, into right ventricle, and out of the ventricle into the conduit. Alternatively, the catheter may be inserted into the femoral vein and passed through the common iliac vein and the inferior vena cava into the right atrium, then through the tricuspid valve, into the right ventricle and out into the conduit. The catheters used for the procedures described herein may include radiopaque markers as are known in the art, and the procedure may be visualized using fluoroscopy, echocardiography, ultrasound, or other suitable means of visualization. [0041] FIG. 3 is a cross-sectional side view of pulmonary valve replacement system 300, having a catheter delivered support structure in accordance with the present invention. Conduit 308 comprises an elongate tubular structure that includes an inner wall that defines lumen 312. Lumen 312 allows fluid communication between right ventricle 116 and pulmonary artery 122. Conduit 308 includes a first end 314 for attaching to ventricle 116 and a second end 316 for attaching to pulmonary artery 122. Stented valve 302 comprises a collapsible valve attached to the interior of a tubular stent. [0042] The stent portion is reduced in diameter and stented valve 302 is mounted on catheter 304. Support structure 306 comprises a flexible material and is also capable of assuming a reduced diameter, being mounted on delivery catheter 304, advanced through the circulatory system of the patient and delivered to treatment site 310, within lumen 312 of conduit 308 as shown in FIG. 3. [0043] In one preferred embodiment, the stented valve 302 and support structure 306 are balloon expandable. In another embodiment, the stented valve and support structure can be self-expanding or a combination of balloon expandable and self-expanding. In the embodiment depicted in FIG. 3, support structure 306 is a tubular scaffold comprising a metallic material or alloy. Examples of suitable metali materials and alloys include, but are not limited to, stainless steel, titanium, platinum, a nickel-titanium alloy, nitinol, iridium, platinum-iridium alloy, gold, tantalum, niobium, and other medically acceptable metals, alone or in combination. In one embodiment of the invention, the body of tubular scaffold 306 comprises a shape memory material such as nitinol, and is self-expanding. [0044] After a conduit 308 has been implanted, it may become calcified or stretch over time. This stretching or calcification can result in a treatment site 310 that is not round and symmetrical. As a result, it may be difficult or impossible to position stented valve 302 in a fixed position, perpendicular to the direction of blood flow within vascular conduit 308, as required for the optimal functioning of stented valve 302. In one embodiment of the invention, the distal portion of catheter 304 is positioned so that support structure 306 is adjacent to treatment site 310, as shown in FIG. 3. When deployed from catheter 304, tubular scaffold 306 expands in diameter and presses against the interior wall of conduit 308 adjacent treatment site 310. [0045] In this embodiment, tubular scaffold 306 has sufficient mechanical strength to reshape the region of the interior lumen of conduit 308 contacted by tubular scaffold 306, as shown in FIG.4. A cylindrical fluid passageway 412, having a constant diameter is formed through the lumen 312 of conduit 308, including treatment site 310. In one embodiment of the invention, the exterior surface of stented valve 302 is cylindrical and is complementary to the cylindrical fluid passageway 412 formed by tubular scaffold 306. Consequently, when stented valve 302 is deployed from catheter 304, within the cylindrical passageway 412 formed by tubular scaffold 306, as shown in FIG.4, the exterior surface of stented valve 302 contacts the inner surface of support structure 306 in close proximity to the wall of the lumen of conduit 308, and is aligned perpendicularly to the flow of blood through conduit 308, and thus improves the functioning of stented valve 302. [0046] In one embodiment of the invention, the exterior surface of the metallic body of support structure 306 is coated with a biostable polymeric material that is nonthrombogenic such as polypropylene, polyethylene, polyurethane, nylon, polytetrafluroethylene (PTFE), and polyester. [0047] To facilitate visualization using fluoroscopy during delivery and accurate placement of support structure 306 within conduit 308, in one embodiment of the invention, at least a portion of support structure 306 comprises a radiopaque material such as, for example, gold, tantalum, and iridium. [0048] In one embodiment, support structure 306 is capable of delivering one or more drugs. In this embodiment, the metallic body of support structure 306 is coated with at least one drug substance such as an anticoagulant drug, antiplatelet drug, anti-inflammatory drug or other drug substance. In one embodiment, the drug substance is mixed with one or more bioabsorbable polymers such polyphosphate ester, polyhydroxybutyrate valerate, and poly (L-lactic acid) to form a uniform coating on the exterior surface of support structure 306 that erodes over a defined period of time and releases the drug substance. [0049] One embodiment of the invention includes a holding means on the interior surface of the support structure. The purpose of the holding means is to prevent migration of stented valve 302 along conduit 308 after implantation due to forces applied by the blood flow through conduit 308. FIG. 5 is a schematic representation of support structure 500 with a bracket. In this embodiment, the tubular body of support structure 506 is substantially the same as support structure 306, but additionally, includes two ring members 502 and 504 located on the inner surface of support structure 506. Ring members 502 and 504 are either molded in the inner surface of support structure 506 or are securely attached to the inner surface of support structure 506. Ring members 502 and 504 are spaced apart so that the distance between ring members 502 and 504 is substantially the same as the length of stented valve 302. When stented valve 302 is delivered between ring members 502 and 504 and expanded against the inner surface of support structure 506, stented valve 302 is held in place and prevented from migrating along the length of the conduit. [0050] FIGS. 6A and 6B portray another embodiment of the invention. Device 600 includes a holding means that comprises at least one mating portion 604 attached to the interior surface 606 of support structure 602. The embodiment portrayed in FIG. 6A includes two mating portions 604. FIG. 6B provides a cross sectional view of support structure 600 taken at 608-608 in FIG. 6A. In this embodiment, there are two complementary receiving portions in the stent portion of stented valve 302. When stented valve 302 is expanded in the interior lumen of support structure 600, the mating portions 604 pass through the complementary receiving portions of stented valve 302 and maintain stented valve 302 in a fixed position within the interior lumen of support structure 602. In one embodiment of the invention, mating portions 604 are cleats and the complementary receiving portions in stented valve 302 are slots that engage the cleats and maintain the stented valve in a fixed position. In one embodiment, the complementary fit between mating portions 604 and the receiving portions comprises a snap fit. In another embodiment of the invention, stented valve 302 is sutured to the interior wall of support structure 602. [0051] FIG. 7 illustrates that, in some preferred embodiments of the current invention, a stented valve device 702 does not have to be implanted directly into the interior of the foundation structure. Instead, the valve is implanted in any symmetrical portion of the conduit whether that is completely inside of, partially inside of, or completely outside of the tubular scaffold or other foundation structure. In the depicted embodiment, the valve support structure 702 is implanted in an area of the conduit 708 that was restored to a symmetric shape after the tubular scaffold 706 was deployed. For the embodiment depicted, the stented valve is shown deployed on the proximal side (relative to the deploying clinician) of the scaffold. In other embodiments, the valve may be implanted on the distal side of the scaffold, or it may be implanted such that the valve support structure is partially in the scaffold. In another embodiment (not depicted), two or more scaffolds are used to restore the conduit to symmetry and the valve can be implanted in any symmetrical portion of the conduit as described above. [0052] FIG. 8 is a flowchart illustrating method 800 for treating right ventricular outflow tract abnormalities by replacing a pulmonary valve in a nonsymmetrical region of a conduit, in accordance with the present invention. Beginning at Block 802, a foundation structure (such as foundation structure 306 or 506) and a stented valve (such as stented valve 302) are mounted on a catheter such as catheter 304. The distal portion of delivery catheter 304 is then passed through the venous system and into a patient's right ventricle 116. This may be accomplished by inserting delivery catheter 304 into either the jugular vein or the subclavian vein, and passing it through the superior vena cava into right atrium 118. The catheter is then passed through tricuspid valve 104, into right ventricle 116, and out of the ventricle into conduit 308. Alternatively, delivery catheter 304 may be inserted into the femoral vein and passed through the common iliac vein and the inferior vena cava into right atrium 118, then through tricuspid valve 104, into right ventricle 116, and out into conduit 308. The catheters used for the procedures described herein may include radiopaque markers as is known in the art, and the procedure may be visualized using fluoroscopy, echocardiography, ultrasound, or other suitable means of visualization. [0053] Next, a foundation structure is deployed from the catheter at the treatment site within a non-symmetric region of either a prosthetic lumen such as lumen 312 or a deformed blood vessel, as indicated in Block 804. A foundation structure such as foundation structure 306 or 506 may be used. The foundation structure is expanded in diameter so that the exterior surface of the foundation structure presses against the interior wall of conduit 308 and reshapes a region of the inner lumen of conduit 308. In this embodiment, tubular scaffold 306 has sufficient mechanical strength to reshape the region the interior lumen of conduit 308 contacted by the support structure. As a consequence, the inner lumen of conduit 308 forms a symmetrical region of uniform diameter surrounding the support structure, as indicated in Block 806. [0054] Next, a stented valve such as stented valve 302 is deployed from the delivery catheter into symmetrical region within the lumen of conduit 308, as indicated in Block 808. The stented valve is expanded, and if a foundation structure such as foundation structure 506 is used, stented valve 302 is positioned so that a mating portion of a holding means on the foundation structure engages a receiving portion on the exterior surface of the stented valve (Block 810). In one embodiment, stented valve 302 is positioned between first and second ring members and expanded. In either case, stented valve 302 is maintained in a fixed position by the holding means within the symmetrical region of conduit 308, and aligned perpendicular with the flow of blood, which allows the valve to function optimally (Block 812). [0055] While the invention has been described with reference to particular embodiments, it will be understood by one skilled in the art that variations and modifications may be made in form and detail without departing from the spirit and scope of the invention. Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3642004 *Jan 5, 1970Feb 15, 1972Life Support Equipment CorpUrethral valveUS3657744 *May 8, 1970Apr 25, 1972Univ MinnesotaMethod for fixing prosthetic implants in a living bodyUS3795246 *Jan 26, 1973Mar 5, 1974Bard Inc C RVenocclusion deviceUS3868956 *Jun 5, 1972Mar 4, 1975Ralph J AlfidiVessel implantable appliance and method of implanting itUS3874388 *Feb 12, 1973Apr 1, 1975Ochsner Med Found AltonShunt defect closure systemUS4425908 *Oct 22, 1981Jan 17, 1984Beth Israel HospitalBlood clot filterUS4501030 *Aug 17, 1981Feb 26, 1985American Hospital Supply CorporationMethod of leaflet attachment for prosthetic heart valvesUS4580568 *Oct 1, 1984Apr 8, 1986Cook, IncorporatedPercutaneous endovascular stent and method for insertion thereofUS4647283 *Nov 13, 1984Mar 3, 1987American Hospital Supply CorporationImplantable biological tissue and process for preparation thereofUS4648881 *Nov 29, 1982Mar 10, 1987American Hospital Supply CorporationImplantable biological tissue and process for preparation thereofUS4655771 *Apr 11, 1983Apr 7, 1987Shepherd Patents S.A.Prosthesis comprising an expansible or contractile tubular bodyUS4662885 *Sep 3, 1985May 5, 1987Becton, Dickinson And CompanyPercutaneously deliverable intravascular filter prosthesisUS4665906 *May 21, 1986May 19, 1987Raychem CorporationMedical devices incorporating sim alloy elementsUS4733665 *Nov 7, 1985Mar 29, 1988Expandable Grafts PartnershipExpandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graftUS4817751 *Feb 29, 1988Apr 4, 1989Toyoda Koki Kabushiki KaishaA driving force distribution transmission for vehicles with four-wheel driveUS4834755 *Mar 4, 1985May 30, 1989Pfizer Hospital Products Group, Inc.Triaxially-braided fabric prosthesisUS4909252 *May 26, 1988Mar 20, 1990The Regents Of The Univ. Of CaliforniaPerfusion balloon catheterUS4917102 *Sep 14, 1988Apr 17, 1990Advanced Cardiovascular Systems, Inc.Guidewire assembly with steerable adjustable tipUS4994077 *Apr 21, 1989Feb 19, 1991Dobben Richard LArtificial heart valve for implantation in a blood vesselUS5002559 *Nov 30, 1989Mar 26, 1991NumedPTCA catheterUS5197979 *Sep 7, 1990Mar 30, 1993Baxter International Inc.Stentless heart valve and holderUS5389106 *Oct 29, 1993Feb 14, 1995Numed, Inc.Impermeable expandable intravascular stentUS5397351 *May 13, 1991Mar 14, 1995Pavcnik; DusanProsthetic valve for percutaneous insertionUS5411552 *Jun 14, 1994May 2, 1995Andersen; Henning R.Valve prothesis for implantation in the body and a catheter for implanting such valve prothesisUS5507767 *Jan 15, 1992Apr 16, 1996Cook IncorporatedSpiral stentUS5713953 *Feb 15, 1996Feb 3, 1998Sorin Biomedica Cardio S.P.A.Cardiac valve prosthesis particularly for replacement of the aortic valveUS5855597 *May 7, 1997Jan 5, 1999Iowa-India Investments Co. LimitedStent valve and stent graft for percutaneous surgeryUS5855601 *Jun 21, 1996Jan 5, 1999The Trustees Of Columbia University In The City Of New YorkArtificial heart valve and method and device for implanting the sameUS5860996 *Apr 29, 1997Jan 19, 1999United States Surgical CorporationOptical trocarUS5861028 *Sep 9, 1996Jan 19, 1999Shelhigh IncNatural tissue heart valve and stent prosthesis and method for making the sameUS5868783 *Apr 16, 1997Feb 9, 1999Numed, Inc.Intravascular stent with limited axial shrinkageUS5876448 *Mar 13, 1996Mar 2, 1999Schneider (Usa) Inc.Esophageal stentUS5888201 *Jun 13, 1997Mar 30, 1999Schneider (Usa) IncTitanium alloy self-expanding stentUS5891191 *Apr 30, 1996Apr 6, 1999Schneider (Usa) IncCobalt-chromium-molybdenum alloy stent and stent-graftUS6027525 *May 23, 1997Feb 22, 2000Samsung Electronics., Ltd.Flexible self-expandable stent and method for making the sameUS6042598 *Apr 5, 1999Mar 28, 2000Embol-X Inc.Method of protecting a patient from embolization during cardiac surgeryUS6051104 *Aug 13, 1997Apr 18, 2000Fort James CorporationSoft single-ply tissue having very low sidenessUS6168614 *Feb 20, 1998Jan 2, 2001Heartport, Inc.Valve prosthesis for implantation in the bodyUS6200336 *Jun 2, 1999Mar 13, 2001Cook IncorporatedMultiple-sided intraluminal medical deviceUS6221006 *Feb 9, 1999Apr 24, 2001Artemis Medical Inc.Entrapping apparatus and method for useUS6221091 *May 25, 1999Apr 24, 2001Incept LlcCoiled sheet valve, filter or occlusive device and methods of useUS6338735 *Mar 15, 1996Jan 15, 2002John H. StevensMethods for removing embolic material in blood flowing through a patient's ascending aortaUS6342070 *Dec 14, 1999Jan 29, 2002Edwards Lifesciences Corp.Stentless bioprosthetic heart valve with patent coronary protuberances and method of surgical use thereofUS6348063 *Jan 18, 2000Feb 19, 2002Mindguard Ltd.Implantable stroke treating deviceUS6350282 *Dec 11, 1995Feb 26, 2002Medtronic, Inc.Stented bioprosthetic heart valveUS6352708 *Oct 14, 1999Mar 5, 2002The International Heart Institute Of Montana FoundationSolution and method for treating autologous tissue for implant operationUS6364905 *Jul 23, 1999Apr 2, 2002Sulzer Carbomedics Inc.Tri-composite, full root, stentless valveUS6370970 *Sep 7, 1999Apr 16, 2002Satoshi HosokawaCargo handling machine including force controlUS6371983 *Oct 3, 2000Apr 16, 2002Ernest LaneBioprosthetic heart valveUS6379383 *Nov 19, 1999Apr 30, 2002Advanced Bio Prosthetic Surfaces, Ltd.Endoluminal device exhibiting improved endothelialization and method of manufacture thereofUS6503272 *Mar 21, 2001Jan 7, 2003Cordis CorporationStent-based venous valvesUS6508833 *Mar 12, 2001Jan 21, 2003Cook IncorporatedMultiple-sided intraluminal medical deviceUS6509930 *Jun 19, 2000Jan 21, 2003Hitachi, Ltd.Circuit for scan conversion of picture signal using motion compensationUS6527800 *Jun 8, 2001Mar 4, 2003Rex Medical, L.P.Vascular device and method for valve leaflet appositionUS6530949 *Jul 10, 2001Mar 11, 2003Board Of Regents, The University Of Texas SystemHoop stentUS6530952 *Dec 21, 2000Mar 11, 2003The Cleveland Clinic FoundationBioprosthetic cardiovascular valve systemUS6558417 *Jul 2, 2001May 6, 2003St. Jude Medical, Inc.Single suture biological tissue aortic stentless valveUS6562058 *Mar 2, 2001May 13, 2003Jacques SeguinIntravascular filter systemUS6569196 *Jun 19, 2000May 27, 2003The Cleveland Clinic FoundationSystem for minimally invasive insertion of a bioprosthetic heart valveUS6673089 *Aug 11, 2000Jan 6, 2004Mindguard Ltd.Implantable stroke treating deviceUS6673109 *Aug 7, 2001Jan 6, 20043F Therapeutics, Inc.Replacement atrioventricular heart valveUS6682558 *May 10, 2001Jan 27, 20043F Therapeutics, Inc.Delivery system for a stentless valve bioprosthesisUS6682559 *Jan 29, 2001Jan 27, 20043F Therapeutics, Inc.Prosthetic heart valveUS6685739 *Jul 9, 2002Feb 3, 2004Scimed Life Systems, Inc.Implantable prosthetic valveUS6689144 *Feb 8, 2002Feb 10, 2004Scimed Life Systems, Inc.Rapid exchange catheter and methods for delivery of vaso-occlusive devicesUS6689164 *Oct 10, 2000Feb 10, 2004Jacques SeguinAnnuloplasty device for use in minimally invasive procedureUS6692512 *Jun 25, 2001Feb 17, 2004Edwards Lifesciences CorporationPercutaneous filtration catheter for valve repair surgery and methods of useUS6702851 *Mar 18, 1998Mar 9, 2004Joseph A. ChinnProsthetic heart valve with surface modificationUS6712842 *Mar 9, 2000Mar 30, 2004Allan WillMethods and devices for lining a blood vessel and opening a narrowed region of a blood vesselUS6719789 *May 21, 2002Apr 13, 20043F Therapeutics, Inc.Replacement heart valveUS6730118 *Oct 11, 2002May 4, 2004Percutaneous Valve Technologies, Inc.Implantable prosthetic valveUS6730377 *Jan 23, 2002May 4, 2004Scimed Life Systems, Inc.Balloons made from liquid crystal polymer blendsUS6733525 *Mar 23, 2001May 11, 2004Edwards Lifesciences CorporationRolled minimally-invasive heart valves and methods of useUS20020032480 *Sep 13, 2001Mar 14, 2002Paul SpenceHeart valve and apparatus for replacement thereofUS20020032481 *Oct 9, 2001Mar 14, 2002Shlomo GabbayHeart valve prosthesis and sutureless implantation of a heart valve prosthesisUS20020052651 *Jan 29, 2001May 2, 2002Keith MyersProsthetic heart valveUS20020058995 *Oct 23, 2001May 16, 2002Stevens John H.Endovascular aortic valve replacementUS20030014104 *May 2, 2002Jan 16, 2003Alain CribierValue prosthesis for implantation in body channelsUS20030023303 *Apr 11, 2002Jan 30, 2003Palmaz Julio C.Valvular prostheses having metal or pseudometallic construction and methods of manufactureUS20030028247 *Jul 26, 2002Feb 6, 2003Cali Douglas S.Method of cutting material for use in implantable medical deviceUS20030036791 *Aug 2, 2002Feb 20, 2003Bonhoeffer PhilippImplant implantation unit and procedure for implanting the unitUS20030040771 *Sep 16, 2002Feb 27, 2003Hideki HyodohMethods for creating woven devicesUS20030040772 *Sep 16, 2002Feb 27, 2003Hideki HyodohDelivery devicesUS20030055495 *Nov 1, 2002Mar 20, 2003Pease Matthew L.Rolled minimally-invasive heart valves and methods of manufactureUS20030069635 *May 28, 2002Apr 10, 2003Cartledge Richard G.Prosthetic heart valveUS20040034411 *Aug 16, 2002Feb 19, 2004Quijano Rodolfo C.Percutaneously delivered heart valve and delivery means thereofUS20040039436 *Aug 8, 2003Feb 26, 2004Benjamin SpenserImplantable prosthetic valveUS20040049224 *Aug 5, 2002Mar 11, 2004Buehlmann Eric L.Target tissue localization assembly and methodUS20040049262 *Jun 9, 2003Mar 11, 2004Obermiller Joseph F.Stent valves and uses of sameUS20040049266 *Sep 11, 2002Mar 11, 2004Anduiza James PeterPercutaneously deliverable heart valveUS20040082904 *Oct 23, 2002Apr 29, 2004Eric HoudeRotary manifold syringeUS20040088045 *Oct 28, 2003May 6, 20043F Therapeutics, Inc.Replacement heart valveUS20040098112 *Nov 14, 2003May 20, 2004Scimed Life Systems, Inc.Implantable prosthetic valveUS20050085841 *Sep 2, 2004Apr 21, 2005Eversull Christian S.Expandable sheath for delivering instruments and agents into a body lumen and methods for useUS20050085842 *Sep 2, 2004Apr 21, 2005Eversull Christian S.Expandable guide sheath and apparatus with distal protection and methods for useUS20050085843 *Sep 17, 2004Apr 21, 2005Nmt Medical, Inc.Quick release knot attachment systemUS20050085890 *Oct 12, 2004Apr 21, 2005Cook IncorporatedProsthesis deployment system retention deviceUS20060052867 *Sep 7, 2004Mar 9, 2006Medtronic, IncReplacement prosthetic heart valve, system and method of implantUS20070055299 *May 21, 2004Mar 8, 2007Shin IshimaruTemporary stents and stent-grafts* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS7682390Jul 30, 2002Mar 23, 2010Medtronic, Inc.Assembly for setting a valve prosthesis in a corporeal ductUS7740655 *Apr 6, 2006Jun 22, 2010Medtronic Vascular, Inc.Reinforced surgical conduit for implantation of a stented valve thereinUS7758606Feb 5, 2004Jul 20, 2010Medtronic, Inc.Intravascular filter with debris entrapment mechanismUS7780726Aug 24, 2010Medtronic, Inc.Assembly for placing a prosthetic valve in a duct in the bodyUS7871436Jan 18, 2011Medtronic, Inc.Replacement prosthetic heart valves and methods of implantationUS7892281Feb 22, 2011Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS7914569May 13, 2005Mar 29, 2011Medtronics Corevalve LlcHeart valve prosthesis and methods of manufacture and useUS7921847Apr 12, 2011Intubix, LlcDevice and method for placing within a patient an enteral tube after endotracheal intubationUS7931684 *Apr 26, 2011Edwards Lifesciences CorporationMinimally-invasive annuloplasty repair segment delivery systemUS7972378Jul 5, 2011Medtronic, Inc.Stents for prosthetic heart valvesUS8002826Oct 14, 2009Aug 23, 2011Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the bodyUS8016877Jun 29, 2009Sep 13, 2011Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8052750Nov 8, 2011Medtronic Ventor Technologies LtdValve prosthesis fixation techniques using sandwichingUS8070801Dec 6, 2011Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valveUS8075615Dec 13, 2011Medtronic, Inc.Prosthetic cardiac valve formed from pericardium material and methods of making sameUS8092487Jan 10, 2012Medtronic, Inc.Intravascular filter with debris entrapment mechanismUS8137398Oct 13, 2008Mar 20, 2012Medtronic Ventor Technologies LtdProsthetic valve having tapered tip when compressed for deliveryUS8157852Jan 22, 2009Apr 17, 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8157853Apr 17, 2012Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8163005 *Apr 24, 2012William A. Cook Australia Pty. Ltd.Vascular bandUS8226710Mar 25, 2011Jul 24, 2012Medtronic Corevalve, Inc.Heart valve prosthesis and methods of manufacture and useUS8241274Aug 14, 2012Medtronic, Inc.Method for guiding a medical deviceUS8312825Nov 20, 2012Medtronic, Inc.Methods and apparatuses for assembly of a pericardial prosthetic heart valveUS8313525Nov 20, 2012Medtronic Ventor Technologies, Ltd.Valve suturing and implantation proceduresUS8348995Jan 8, 2013Medtronic Ventor Technologies, Ltd.Axial-force fixation member for valveUS8348996Mar 23, 2007Jan 8, 2013Medtronic Ventor Technologies Ltd.Valve prosthesis implantation techniquesUS8414643Apr 9, 2013Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation memberUS8430927Feb 2, 2009Apr 30, 2013Medtronic, Inc.Multiple orifice implantable heart valve and methods of implantationUS8506620Nov 13, 2009Aug 13, 2013Medtronic, Inc.Prosthetic cardiac and venous valvesUS8511244Oct 19, 2012Aug 20, 2013Medtronic, Inc.Methods and apparatuses for assembly of a pericardial prosthetic heart valveUS8512397Apr 27, 2009Aug 20, 2013Sorin Group Italia S.R.L.Prosthetic vascular conduitUS8535373Jun 16, 2008Sep 17, 2013Sorin Group Italia S.R.L.Minimally-invasive cardiac-valve prosthesisUS8539662Jun 16, 2008Sep 24, 2013Sorin Group Italia S.R.L.Cardiac-valve prosthesisUS8540768Dec 30, 2011Sep 24, 2013Sorin Group Italia S.R.L.Cardiac valve prosthesisUS8562672Nov 18, 2005Oct 22, 2013Medtronic, Inc.Apparatus for treatment of cardiac valves and method of its manufactureUS8579966Feb 4, 2004Nov 12, 2013Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8591570Mar 14, 2008Nov 26, 2013Medtronic, Inc.Prosthetic heart valve for replacing previously implanted heart valveUS8603159Dec 11, 2009Dec 10, 2013Medtronic Corevalve, LlcProsthetic valve for transluminal deliveryUS8613765Jul 7, 2011Dec 24, 2013Medtronic, Inc.Prosthetic heart valve systemsUS8623077Dec 5, 2011Jan 7, 2014Medtronic, Inc.Apparatus for replacing a cardiac valveUS8628566Jan 23, 2009Jan 14, 2014Medtronic, Inc.Stents for prosthetic heart valvesUS8628570Aug 18, 2011Jan 14, 2014Medtronic Corevalve LlcAssembly for placing a prosthetic valve in a duct in the bodyUS8652204Jul 30, 2010Feb 18, 2014Medtronic, Inc.Transcatheter valve with torsion spring fixation and related systems and methodsUS8673000May 20, 2011Mar 18, 2014Medtronic, Inc.Stents for prosthetic heart valvesUS8685077Mar 14, 2012Apr 1, 2014Medtronics, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS8685084Dec 28, 2012Apr 1, 2014Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly methodUS8696689Mar 18, 2008Apr 15, 2014Medtronic Ventor Technologies Ltd.Medical suturing device and method for use thereofUS8696743Apr 16, 2009Apr 15, 2014Medtronic, Inc.Tissue attachment devices and methods for prosthetic heart valvesUS8715337Nov 4, 2008May 6, 2014Cook Medical Technologies LlcAortic valve stent graftUS8721708Sep 23, 2011May 13, 2014Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8721714Sep 17, 2008May 13, 2014Medtronic Corevalve LlcDelivery system for deployment of medical devicesUS8747458Aug 20, 2007Jun 10, 2014Medtronic Ventor Technologies Ltd.Stent loading tool and method for use thereofUS8747459Dec 6, 2007Jun 10, 2014Medtronic Corevalve LlcSystem and method for transapical delivery of an annulus anchored self-expanding valveUS8747460Dec 23, 2011Jun 10, 2014Medtronic Ventor Technologies Ltd.Methods for implanting a valve prothesisUS8758430 *Jan 23, 2009Jun 24, 2014Jenavalve Technology, Inc.Medical apparatus for the therapeutic treatment of an insufficient cardiac valveUS8771302Apr 6, 2007Jul 8, 2014Medtronic, Inc.Method and apparatus for resecting and replacing an aortic valveUS8771345Oct 31, 2011Jul 8, 2014Medtronic Ventor Technologies Ltd.Valve prosthesis fixation techniques using sandwichingUS8771346Jul 25, 2011Jul 8, 2014Medtronic Ventor Technologies Ltd.Valve prosthetic fixation techniques using sandwichingUS8777980Dec 23, 2011Jul 15, 2014Medtronic, Inc.Intravascular filter with debris entrapment mechanismUS8784478Oct 16, 2007Jul 22, 2014Medtronic Corevalve, Inc.Transapical delivery system with ventruculo-arterial overlfow bypassUS8795354 *Mar 4, 2011Aug 5, 2014Edwards Lifesciences CorporationLow-profile heart valve and delivery systemUS8801776Feb 24, 2009Aug 12, 2014Medtronic Vascular, Inc.Infundibular reducer devicesUS8801779May 10, 2011Aug 12, 2014Medtronic Corevalve, LlcProsthetic valve for transluminal deliveryUS8808369Oct 5, 2010Aug 19, 2014Mayo Foundation For Medical Education And ResearchMinimally invasive aortic valve replacementUS8834563Dec 16, 2009Sep 16, 2014Sorin Group Italia S.R.L.Expandable prosthetic valve having anchoring appendagesUS8834564Mar 11, 2010Sep 16, 2014Medtronic, Inc.Sinus-engaging valve fixation memberUS8840661May 13, 2009Sep 23, 2014Sorin Group Italia S.R.L.Atraumatic prosthetic heart valve prosthesisUS8845720 *Sep 20, 2011Sep 30, 2014Edwards Lifesciences CorporationProsthetic heart valve frame with flexible commissuresUS8863746Jan 12, 2009Oct 21, 2014Kim Technology Partners, LPDevice and method for placing within a patient an enteral tube after endotracheal intubationUS8876894Mar 23, 2007Nov 4, 2014Medtronic Ventor Technologies Ltd.Leaflet-sensitive valve fixation memberUS8876895Mar 23, 2007Nov 4, 2014Medtronic Ventor Technologies Ltd.Valve fixation member having engagement armsUS8876896Dec 7, 2011Nov 4, 2014Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS8920492Aug 21, 2013Dec 30, 2014Sorin Group Italia S.R.L.Cardiac valve prosthesisUS8951280Jun 9, 2010Feb 10, 2015Medtronic, Inc.Cardiac valve procedure methods and devicesUS8956402Sep 14, 2012Feb 17, 2015Medtronic, Inc.Apparatus for replacing a cardiac valveUS8961593Dec 5, 2013Feb 24, 2015Medtronic, Inc.Prosthetic heart valve systemsUS8986329Oct 28, 2013Mar 24, 2015Medtronic Corevalve LlcMethods for transluminal delivery of prosthetic valvesUS8986361Oct 17, 2008Mar 24, 2015Medtronic Corevalve, Inc.Delivery system for deployment of medical devicesUS8998979Feb 11, 2014Apr 7, 2015Medtronic Corevalve LlcTranscatheter heart valvesUS8998981Sep 15, 2009Apr 7, 2015Medtronic, Inc.Prosthetic heart valve having identifiers for aiding in radiographic positioningUS9060856Feb 11, 2014Jun 23, 2015Medtronic Corevalve LlcTranscatheter heart valvesUS9060857Jun 19, 2012Jun 23, 2015Medtronic Corevalve LlcHeart valve prosthesis and methods of manufacture and useUS9061119 *Oct 8, 2008Jun 23, 2015Edwards Lifesciences CorporationLow profile delivery system for transcatheter heart valveUS9066799Jan 20, 2011Jun 30, 2015Medtronic Corevalve LlcProsthetic valve for transluminal deliveryUS9089422Jan 23, 2009Jul 28, 2015Medtronic, Inc.Markers for prosthetic heart valvesUS9095434 *Jan 7, 2011Aug 4, 2015Edwards Lifesciences CorporationMethod and apparatus for replacing a prosthetic valveUS9138312Jun 6, 2014Sep 22, 2015Medtronic Ventor Technologies Ltd.Valve prosthesesUS9138314Feb 10, 2014Sep 22, 2015Sorin Group Italia S.R.L.Prosthetic vascular conduit and assembly methodUS9149357Dec 23, 2013Oct 6, 2015Medtronic CV Luxembourg S.a.r.l.Heart valve assembliesUS9149358Jan 23, 2009Oct 6, 2015Medtronic, Inc.Delivery systems for prosthetic heart valvesUS9161836Feb 10, 2012Oct 20, 2015Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prosthesesUS9216082Mar 10, 2009Dec 22, 2015Symetis SaStent-valves for valve replacement and associated methods and systems for surgeryUS9226826Feb 24, 2010Jan 5, 2016Medtronic, Inc.Transcatheter valve structure and methods for valve deliveryUS9237886Apr 14, 2008Jan 19, 2016Medtronic, Inc.Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereofUS9248017May 20, 2011Feb 2, 2016Sorin Group Italia S.R.L.Support device for valve prostheses and corresponding kitUS9289289Feb 10, 2012Mar 22, 2016Sorin Group Italia S.R.L.Sutureless anchoring device for cardiac valve prosthesesUS9295550Mar 28, 2014Mar 29, 2016Medtronic CV Luxembourg S.a.r.l.Methods for delivering a self-expanding valveUS9301834Oct 16, 2009Apr 5, 2016Medtronic Ventor Technologies Ltd.Sinus-engaging valve fixation memberUS9314334Nov 25, 2013Apr 19, 2016Edwards Lifesciences CorporationConformal expansion of prosthetic devices to anatomical shapesUS9314335Sep 19, 2008Apr 19, 2016Edwards Lifesciences CorporationProsthetic heart valve configured to receive a percutaneous prosthetic heart valve implantationUS9331328Dec 12, 2011May 3, 2016Medtronic, Inc.Prosthetic cardiac valve from pericardium material and methods of making sameUS9333100Nov 22, 2013May 10, 2016Medtronic, Inc.Stents for prosthetic heart valvesUS9339382Jan 24, 2014May 17, 2016Medtronic, Inc.Stents for prosthetic heart valvesUS9364322Dec 20, 2013Jun 14, 2016Edwards Lifesciences CorporationPost-implant expandable surgical heart valve configurationsUS9375310Dec 20, 2013Jun 28, 2016Edwards Lifesciences CorporationSurgical heart valves adapted for post-implant expansionUS9387071Sep 12, 2014Jul 12, 2016Medtronic, Inc.Sinus-engaging valve fixation memberUS9393112Feb 27, 2014Jul 19, 2016Medtronic Ventor Technologies Ltd.Stent loading tool and method for use thereofUS9393115Jan 23, 2009Jul 19, 2016Medtronic, Inc.Delivery systems and methods of implantation for prosthetic heart valvesUS20050171601 *Mar 30, 2005Aug 4, 2005Cosgrove Delos M.Minimally-invasive annuloplasty repair segment delivery systemUS20050203605 *Mar 15, 2005Sep 15, 2005Medtronic Vascular, Inc.Radially crush-resistant stentUS20070017527 *Jul 25, 2005Jan 25, 2007Totz Kenneth ADevice and method for placing within a patient an enteral tube after endotracheal intubationUS20080167705 *Jan 7, 2008Jul 10, 2008Cook IncorporatedShort wire stent delivery system with splittable outer sheathUS20080208327 *Feb 27, 2007Aug 28, 2008Rowe Stanton JMethod and apparatus for replacing a prosthetic valveUS20080215134 *Mar 3, 2008Sep 4, 2008William Cook Australia Pty. Ltd.Vascular bandUS20090125002 *Jan 12, 2009May 14, 2009Km TechnologiesDevice and method for placing within a patient an enteral tube after endotracheal intubationUS20090125098 *Nov 4, 2008May 14, 2009Cook IncorporatedAortic valve stent graftUS20100049306 *Feb 24, 2009Feb 25, 2010Medtronic Vascular, Inc.Infundibular Reducer DevicesUS20100076548 *Mar 25, 2010Edwards Lifesciences CorporationProsthetic Heart Valve Configured to Receive a Percutaneous Prosthetic Heart Valve ImplantationUS20100100167 *Oct 17, 2008Apr 22, 2010Georg BortleinDelivery system for deployment of medical devicesUS20110004148 *Feb 6, 2009Jan 6, 2011Terumo Kabushiki KaishaDevice for local intraluminal transport of a biologically and physiologically active agentUS20110106244 *Jan 23, 2009May 5, 2011Markus FerrariMedical apparatus for the therapeutic treatment of an insufficient cardiac valveUS20110166636 *Jul 7, 2011Edwards Lifesciences CorporationMethod and Apparatus for Replacing a Prosthetic ValveUS20110218619 *Sep 8, 2011Edwards Lifesciences CorporationLow-profile heart valve and delivery systemUS20120078357 *Sep 20, 2011Mar 29, 2012Edwards Lifesciences CorporationProsthetic Heart Valve Frame With Flexible CommissuresUS20120271398 *Sep 10, 2010Oct 25, 2012Symetis SaAortic bioprosthesis and systems for delivery thereofUSD732666Aug 9, 2011Jun 23, 2015Medtronic Corevalve, Inc.Heart valve prosthesisWO2009061419A1 *Nov 6, 2008May 14, 2009Cook IncorporatedAortic valve stent graftWO2009108615A1 *Feb 24, 2009Sep 3, 2009Medtronic Vascular Inc.Infundibular reducer devicesWO2010080746A2 *Jan 5, 2010Jul 15, 2010Intubix, LlcImproved device and method for placing within a patient an enteral tube after endotracheal intubationWO2010080746A3 *Jan 5, 2010Oct 21, 2010Intubix, LlcImproved device and method for placing within a patient an enteral tube after endotracheal intubation* Cited by examinerClassifications U.S. Classification623/1.26, 623/2.11, 623/2.18International ClassificationA61F2/24, A61F2/90Cooperative ClassificationA61F2/2436, A61F2/2475, A61F2/2418, A61F2/2412, A61F2/2433, A61F2250/0063European ClassificationA61F2/24DLegal EventsDateCodeEventDescriptionApr 18, 2006ASAssignmentOwner name: MEDTRONIC VASCULAR, INC., CALIFORNIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FRANCIS, RICHARD WILLIAM ALAN;REEL/FRAME:017487/0058Effective date: 20060418RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services