Source: https://patents.google.com/patent/DE4235506A1/en
Timestamp: 2020-08-07 22:17:54
Document Index: 195437873

Matched Legal Cases: ['arts 34', 'art 34', 'art 34', 'art 35', 'art 34', 'art 35', 'art 34', 'art 35', 'arts 34', 'art 35', 'art 34', 'arts 34', 'art 34', 'art 35']

DE4235506A1 - Drug injection catheter - Google Patents
Drug injection catheter
DE4235506A1
DE4235506A1 DE19924235506 DE4235506A DE4235506A1 DE 4235506 A1 DE4235506 A1 DE 4235506A1 DE 19924235506 DE19924235506 DE 19924235506 DE 4235506 A DE4235506 A DE 4235506A DE 4235506 A1 DE4235506 A1 DE 4235506A1
DE19924235506
1992-10-21 Application filed by Bavaria Med Tech filed Critical Bavaria Med Tech
1994-04-28 Publication of DE4235506A1 publication Critical patent/DE4235506A1/en
239000003814 drug Substances 0.000 title claims abstract description 33
239000011797 cavity materials Substances 0.000 claims abstract description 5
210000000056 organs Anatomy 0.000 abstract description 4
An injection catheter (10; 50; 100; 210) has needles (26) which can be caused to project laterally from apertures (28) in the catheter head. The needles (26) are hollow and medicaments can be injected through them into body cavities, blood vessels and tubular organs and their environnment. In an injection balloon catheter, a prior art balloon (211) is fitted on the injection section (214) and can be inflated and deflated through the inner lumen (216) of the multi-lumen tube (220).
The invention relates to catheters according to the preamble of claim 1.
For the medical treatment of patients, systems are useful with which Medicines can be administered directly to the affected area in the body can. For treatment within hollow organs, body cavities or blood various catheters have been proposed, with which drugs ge near the area of the tissue to be treated can be brought. The simplest catheters of this type are infusion catheters ter which contain one or more holes in the vicinity of the catheter tip or are even perforated. These are expanded so that they have good contact with the Get the wall of the artery so that the medicine is directly attached to the tissue can be supplied. This is how you can make an anoplastic balloon place that contains a number of small holes and when feeding the medicine is inflated under pressure, lies against the wall of the artery and with which the drugs are then introduced into the tissue under pressure.
A disadvantage of such concepts is that the drug is only for a short time Time, and the amount of drug supplied is uncertain. If simple infusion catheters are used, the drug can also be very be washed away quickly. This can result in an infusion for the duration of several days is necessary to take a fictitious drug to achieve concentration at the area to be treated. That means one long hospital stays and a high risk of infection or other complications. In addition, the balloon shown catheters penetrate medicine deeper than desired into the wall, as with relatively high pressure is worked. This allows inner Layers, especially the endothelium of the artery, are damaged.
The object of the invention is to provide a catheter that allows under Avoiding the disadvantages outlined above, medicines simple and safe Places inside the body preferably body cavities, hollow organs or veins to apply where the drug is needed.
The object is achieved by a catheter according to the main claim. Further developments of the invention are in the dependent subclaims featured.
According to the invention, a catheter has needles or cannulas. These needles are held in a retracted position within the outer shaft. In The catheter can enter this position into a hollow organ or into the bloodstream, in particular an artery is introduced. Furthermore, the catheter is equipped with a device device with which the needles are pushed out of the catheter can. This movement is initiated and carried out when the catheter is in the desired position. The needles lay against the species wall or tissue wall and penetrate into it. The needles are hollow needles with a needle channel through which the drug is introduced into the tissue that can.
To move the needles in the catheter in the longitudinal axis opposite the outer shaft slidable inner tube on which the Na deln are attached so that the inner tube this on the fabric wall or in the tissue pushes. Another option is to attach the needles to a balloon-like envelope that expands under pressure. The postponement the needles in this version are applied by applying pressure in the sheath causes. Finally, it is also intended to ver the needles with extensions turn and move this whole in the catheter.
The drug or fluid is delivered from the catheter end that is outside the human body. So that the medicine doesn't get too deep in penetrates the tissue wall, it is expedient to design the needle tips in such a way that the ground end faces, which on the fabric wall, for. An artery, contact, only penetrate them slightly or as parallel to the wall as possible come to lie. This is achieved in that the end faces on the extend the needle tips as parallel as possible to the catheter axis. Around To ensure a preferred mode of application, it is provided that the needles also penetrate something into the fabric wall. Therefore, the normal should be on the Face not exactly parallel to the needle axis, but at least around deviate a small angle so that the needles are not only flat on the fabric wall, but slightly pressed into the tissue with the tip can be. The force applied during handling and the angle then determine how deep the needle tips penetrate into the tissue so that a targeted deep injection z. B. a vessel wall is possible. Of course Lich the needle tip of the desired type of application is appropriate grind and can e.g. B. blunt, rounded or provided with a facet be educated.
According to a development in the invention, the posi tion used in the longitudinal direction of the catheter, which is a mechanical Have outward bias so that the needles when attached to a Actuator to be moved outward toward the Move wall. Are the needles made more flexible so that the pretension not sufficient to guide the needles completely towards the wall One must also provide needle guides on the catheter tip with which the needles to be bent and pushed towards the wall.
In one embodiment, the movement mechanism is an in catheter Longitudinally movable multi-lumen tube that has several channels that extend from the catheter tip to the opposite end of the catheter extend. These channels are under tension at the tip of the catheter bent needles attached. By moving the multi-lumen tube in the Catheter outer shaft, the needles are moved in the longitudinal direction and be because of their pre-tension on the fabric wall. For actuation is a device at the end opposite the catheter tip Stigt, which consists essentially of two parts. Here is the first part attached to the catheter outer shaft and to the second part of the multi-lumen tube. Both parts are held apart with a spring, so that in Rest position the needles are inside the outer shaft of the catheter. When the two parts are pressed together, the multi-lumen tube becomes in the Au The shaft is moved forward so that the needles come out of the catheter tip move out.
A similar device can also be used for actuation when the needles go through a pressurized balloon-like sheath should be pressed outside, the compression of the two parts of the Actuator then builds up the appropriate pressure.
It is also contemplated that the tubular attached to the needles Extensions in their entire length through the catheter to the Actuating device run and longitudinally displaceable with this in the catheter in order to be able to push the needles out of the catheter tip. The Drug is applied to the actuator under pressure in initiated the needle extensions.
Further advantages and features of the invention also result from the following description of exemplary embodiments in connection with the Claims and the drawing. It shows
Figure 1 is a schematic representation of a catheter according to the invention with needles in a retracted position.
FIG. 2 shows the catheter according to the invention of Figure 1 with outwardly ver inserted needles.
Figure 3 shows an actuator for moving a multi-lumen tube in the catheter.
Fig. 4 is a radial section through another embodiment of the invention;
Fig. 5 shows another embodiment of the catheter according to the invention;
Fig. 6 shows an actuator for moving the needles in the catheter. Fig. 5;
Fig. 7 is an enlarged scale section along the line VII-VII of Fig. 5.
Fig. 1 shows a catheter 10 which may be inserted on a guide wire 5 in a known way in the body. The catheter 10 has an outer shaft 12 , at the end of which a catheter tip 14 is attached. The catheter tip 14 can be firmly connected to the outer shaft 12 by welding or gluing. The catheter tip 14 has a channel running in the longitudinal direction, through which a guide wire 5 is passed. Furthermore, an inner tube 20 is located within the outer shaft 12 , which is displaceable in the longitudinal direction. This tube has a channel 22 in the center, through which the guide wire 5 is guided. Furthermore, channels 24 (lumens) are provided in the inner tube, at the catheter tip end of which hollow nails 26 are fastened. The catheter tip 14 is provided with grooves or depressions of suitable shape which run in the longitudinal direction and which end in openings 28 . These openings can emerge laterally as well as in a rounded or conical catheter tip.
The hollow needles 26 are under a mechanical pretension, which they press radially on the outer shaft 12 , and they are held laterally by the groove walls against pivoting. When the inner tube 20 is pushed forward in the outer shaft 12 , the needles are pushed forward and can move outwards through openings 28 due to the pretension, where they lie against the tissue wall. Thereafter, a drug can be supplied to the tissue through the channels 24 and not shown channels in the hollow needles 26 . The drug then emerges from the end face 30 of the needles 26 . The end face 30 of the extended needles is preferably arranged so that it is parallel to the catheter axis in the longitudinal direction. This means that surface 30 also lies flat against the fabric wall and can only be inserted deeper into the wall with greater effort. If you want to penetrate deeper into the wall area, it is advisable to arrange the normal of the surfaces 30 differently from the vertical on the catheter axis so that the needle cuts into the wall somewhat. Of course, other needle cuts adapted to the application can also be used. In the Ausführungsbei game of FIG. 1 and FIG. 2 several needles 26 are provided, which emerge at several ren sides of the catheter 10 due to the displacement of the inner tube 20 so that the catheter is all sides supported on the tissue wall and is thereby held in the center. As a result, the surfaces 30 lie against the wall in a defined manner and inadvertent washing away of the medicament or poor contact of an end surface 30 on the tissue wall is avoided.
At least 3 needles should be used for good support. It is ever however any number of needles are possible, both uniform and can be distributed unevenly across the cross section. With more needles the flow of the drug can also be increased. With very thin veins or fabric, however, there may not be enough space for a larger one Catheter is present; then you will be content with a single needle.
If several needles 26 are necessary because of the better stability or the higher drug flow, the inner tube 20 is preferably a multi-lumen tube.
Fig. 3 shows the actuating device 30, as it can be used to determine the displacement of the needles in a catheter according to FIGS. 1 and Fig. 2 to effect. This actuator essentially consists of two parts 34 and 35 . The part 34 remains fixed relative to the catheter and will be referred to below as the static part 34 . A movable part 35 is arranged opposite this. The outer shaft 12 is fastened in the static part 34 and the inner tube 20 in the movable part 35 . A guide 36 on the static part 34 and a guide 38 on the movable part 35 interlock so that the inner tube 20 can only move axially to the outer shaft 12 . An Fe of 40 pushes apart parts 34 and 35 . The distance between the end of the Füh tion 38 from the opposite stop is chosen so that the needles 26 are safely in the retracted position shown in FIG. 1. If the movable part 35 and the static part 34 are pressed together, the inner tube moves axially in the direction of the catheter tip, so that a position according to FIG. 2 is reached in which the needles are guided to the vessel wall due to their pretension.
From Fig. 3 it can be seen that the inner tube 20 has a region 42 on which the guide wire 5 is guided out of the catheter 10 . Through an opening 44 the drug can now be inserted and guided in the inner tube up to the needles.
In FIG. 4 is a cross section through another embodiment of the catheter. This catheter 50 again has an outer shaft 12 . A guide wire 5 is again drawn in the center of the catheter. The outer shaft 12 has holes 52 can be led out through the needles 54 from the catheter outer shaft 12 again here. The needles 54 are attached to an inner tube 56 . Another hose 58 is arranged between the inner hose 56 and the guide wire 5 . The inner tube 56 is so ela tical that it inflates like a balloon between hose 56 and hose 58 and presses against the outer shell 12 . As a result, the needles 54 are pushed out through the holes 52 and can rest against the vessel wall. In this example, a different shape of the needles is shown, in particular the contact surface 60 is designed differently than the contact surface of the needles according to FIG. 1 and FIG. 2. With these needle surfaces 60 , the surface normal is not perpendicular to the catheter axis, which makes it suitable for Needle tips is possible to penetrate deeper into the vessel wall. The advantages have already been described above. However, it is also possible to equip the needles 56 with end faces 60 which, like the end faces 30 in the first embodiment, lie flat against the fabric wall.
In the example shown in Fig. 4, the needles are supplied with drug through separate channels and the cavity between tubes 56 and 58 is pressurized independently. This avoids a major disadvantage according to the prior art with the balloon-like inflatable catheters, since a lower application pressure can also be used for the medicament.
The device for operating the catheter 50 can be constructed similarly to that according to FIG. 3 for the previous exemplary embodiment. By compressing the two parts 34 and 35 , the pressure for inflating the inner tube 56 can be generated. Both exemplary embodiments of the invention have the advantage that a targeted injection into a vessel wall is possible through the use of the needles 26 or 54 . By appropriate design of the surfaces 30 and 60 can also influence the depth of penetration of the Na del and thus the drug.
In FIG. 5 another embodiment of the catheter 110 is shown, in which the resiliently biased outwardly needles are provided with tubular extensions 126 26th These extensions may be integrally formed with the needles and pass through the channels of a multi-lumen tubing catheter, the diameter of the channels being large enough to allow the extensions 126 of the needles 26 to slide easily therein.
At the front end of the multi-lumen tube, an outer shaft 112 is fastened, in which the needles are guided and in which the needles can be withdrawn. As already explained, the catheter tip 14 cooperating with the outer shaft 112 is designed such that it guides the elastically pre-tensioned needles 26 in the desired manner when ejecting it. In this case, also as shown in FIGS. 5 and 7 is provided that the outer shaft 112 is provided at the front inner region with a compression 113, the recesses in addition to the groove-off in the catheter tip, the needle leads and secures against pivoting upon exiting. The guide wire 5 runs through the catheter tip in a known manner. The catheter tip and the outer sleeve are preferably made of metal or a hard, well sliding plastic material.
Actuating device 132 according to FIG. 6 serves to move the needles 26 with their extensions 126. It is constructed essentially like the actuating device 30 according to FIG. 3. On the fixed part 34 , the rear end of the multi-lumen tube 120 is fastened, while the needle extensions 126 extend to the movable part 35 and are held there in such a way that the fluid or medicament from the connection volume 139 through the free channel openings, preferably under predetermined pressure, can be supplied. The handling of the actuating device corresponds to that of FIG. 3, wherein the device can be designed to be handy so that it can be operated with one hand.
It is envisaged to have an even number and an odd number of Na deln to use, which both uniformly and unevenly over the catheter cross section can be distributed.
When using z. B. two needles can also be provided that the Guide wire is guided off-center, for example through a third channel of the multi-lumen tube. Then the guide wire can also be off-center emerge from the tip of the catheter.
A catheter of the type described above preferably has a diameter between about 0.5 mm and 5 mm, with a length of the catheter tip of about 1 mm up to 10 mm.
1. Catheter ( 10 , 50 ) for injecting a fluid or a medicament, with a catheter tip ( 14 ) that can be inserted into a hollow organ or a body cavity or a vein and a catheter outer shaft ( 12 ), characterized in that
that at least one needle ( 26 , 54 ) is displaceably arranged in the vicinity of the catheter tip ( 14 ) such that the needle tip lies in a retracted position within the outer catheter shaft ( 12 ) and projects in a pushed-out position over the outer catheter shaft ( 12 ),
that an actuating device can be attached to the catheter ( 10 , 50 ), with which the needle tip can be displaced through the catheter outer shaft, and
that the at least one needle ( 26 , 54 ) is a hollow needle with a needle channel through which the fluid or the medicament can be applied through the needle tip.
2. Catheter according to claim 1, characterized in that the at least one needle is attached to a tube ( 20 , 56 ) which is displaceable in the longitudinal axis in the catheter ( 10 , 50 ).
3. Catheter according to claim 1, characterized in that the at least one needle is attached to an inner tube ( 56 ) which is outside of an inner tube ( 58 ), the gap being pressurizable to the inner tube ( 56 ) expand and move the needles through the catheter outer shaft ( 12 ).
4. Catheter according to claim 1, characterized in that at least one needle with a tubular extension ( 126 ) in the catheter ( 120 ) is longitudinally displaceable.
5. Catheter according to any one of claims 1-3, characterized in that the fluid or the drug via the inner tube ( 20 ) or through the inner tube ( 58 ) of the at least one needle ( 54 ) can be supplied.
6. Catheter according to claim 4, characterized in that the fluid or the drug via the tubular extension ( 126 ) of the at least one needle ( 26 ) can be fed.
7. Catheter according to one or more of claims 1 to 6, characterized in that an even or odd number of needles ( 26 , 54 ) over the cross section of the catheter is used evenly or unevenly distributed.
8. Catheter according to one or more of claims 1 to 7, characterized, that three needles arranged at an angular distance of 120 ° use Find.
9. Catheter according to one of claims 1 to 8, characterized in that the needle tips have an end face ( 30 ) which, in the pushed-out position, run approximately parallel to the catheter axis.
10. Catheter according to claim 3, characterized in that the needle tips have an end face ( 60 ), the normal of which in the pushed-out position extend at a flat angle to the radial direction of the catheter ( 50 ).
11. Catheter according to one or more of claims 1 to 7, characterized in that the longitudinally displaceable needles ( 26 ) are pretensioned in such a way that they move in the longitudinal direction into the projecting position through the outer catheter shaft ( 12 ).
12. Catheter according to one or more of claims 1 to 11, characterized in that needle guides ( 28 ) are arranged on the catheter tip ( 14 ), these allowing both a laterally and forwardly directed exit of the needles ( 26 ).
13. Catheter according to claims 1 and 2, characterized in that the inner tube ( 20 ) which is displaceable in the longitudinal direction of the catheter has a plurality of channels which extend from an area in the vicinity of the catheter tip ( 14 ) to the opposite end of the catheter ( 10 ). and in the channels ( 24 ) of the catheter tip side, bent needles ( 26 ) are fastened, the channels ( 24 ) being suitable for supplying fluids or medicaments from one end of the catheter to the needle tips.
14. Catheter according to claims 4 and 6, characterized in that the catheter ( 120 ) is formed as a multi-lumen tube with a plurality of channels which extend from the catheter tip ( 14 ) to the opposite end of the catheter and through which the displaceable extensions ( 126 ) of the needles ( 26 ) extend to the catheter tip.
15. Catheter according to one or more of claims 1 to 14, characterized in that an actuating device ( 32 ) is arranged on the opposite end of the catheter tip ( 14 ), by pressing two parts ( 34 , 35 ) the needles by the Catheter outer shaft ( 12 ) moves outwards.
In that the inner hose 16. A catheter according to claim 13, characterized in that a displaceable in the catheter outer shaft (12) multi-lumen tube (20),
that the catheter outer shaft ( 12 ) on one part ( 34 ) and the multi-lumen tube ( 20 ) on the other part ( 35 ) of the actuating device ( 32 ) is attached,
that the two parts ( 34 , 35 ) are held apart by spring force,
and that when the two parts are pressed together against the spring force, one or more needles ( 26 ) fastened in the multi-lumen tube ( 20 ) are moved from the retracted position to the outwardly projecting position.
17. Catheter according to claims 14 and 15, characterized in that the actuating device ( 132 ) is designed such that on one part ( 34 ) of the multi-lumen tube and on the other part ( 35 ) the extensions of the needles are attached, that the two parts ( 34 , 35 ) are held apart by spring force, and that when the two parts are pressed together against the spring force, the extensions ( 126 ) in the multi-lumen tube are moved longitudinally and the needles ( 26 ) are moved from the retracted position to the outwardly projecting position.
DE19924235506 1992-10-21 1992-10-21 Drug injection catheter Withdrawn DE4235506A1 (en)
DE19924235506 DE4235506A1 (en) 1992-10-21 1992-10-21 Drug injection catheter
US08/132,876 US5354279A (en) 1992-10-21 1993-10-07 Plural needle injection catheter
JP50962994A JP3330944B2 (en) 1992-10-21 1993-10-13 Drug infusion catheter
DE1993501654 DE59301654D1 (en) 1992-10-21 1993-10-13 Catheter for injection of medicinal products
EP19930924039 EP0689467B1 (en) 1992-10-21 1993-10-13 Catheter for injecting medicaments
RU95113485A RU2129888C1 (en) 1992-10-21 1993-10-13 Drug injection catheter
SK50995A SK50995A3 (en) 1992-10-21 1993-10-13 Catheter for injecting medicaments
CA 2146989 CA2146989C (en) 1992-10-21 1993-10-13 Catheter for the injection of medicines
DK93924039T DK0689467T3 (en) 1992-10-21 1993-10-13 Catheter for injection of medication
HU9500980A HU217867B (en) 1992-10-21 1993-10-13 Catheter
PL30846393A PL172768B1 (en) 1992-10-21 1993-10-13 Drug injection catheter
AT93924039T AT134137T (en) 1992-10-21 1993-10-13 Catheter for injection of medicinal products
PCT/EP1993/002829 WO1994008653A1 (en) 1992-10-21 1993-10-13 Catheter for injecting medicaments
ES93924039T ES2083876T3 (en) 1992-10-21 1993-10-13 Catheter for injecting medicines.
CZ95973A CZ285764B6 (en) 1992-10-21 1993-10-13 Catheter for injection of liquids
AU53696/94A AU693078B2 (en) 1992-10-21 1993-10-13 Catheter for injecting medicaments
TW82108603A TW242118B (en) 1992-10-21 1993-10-16
NO951490A NO951490D0 (en) 1992-10-21 1995-04-20 Catheters
FI951879A FI951879A (en) 1992-10-21 1995-04-20 Drug injection catheter
GR960400895T GR3019507T3 (en) 1992-10-21 1996-04-02 Catheter for injecting medicaments
HK213396A HK213396A (en) 1992-10-21 1996-12-05 Catheter for injecting medicaments
DE4235506A1 true DE4235506A1 (en) 1994-04-28
DE19924235506 Withdrawn DE4235506A1 (en) 1992-10-21 1992-10-21 Drug injection catheter
DE1993501654 Expired - Lifetime DE59301654D1 (en) 1992-10-21 1993-10-13 Catheter for injection of medicinal products
NO (1) NO951490D0 (en)
AT411328B (en) * 2000-07-12 2003-12-29 Universitaetsklinikum Freiburg Tube system for the reconstruction of a urine tube
EP3257547A1 (en) * 2011-06-06 2017-12-20 The Cleveland Clinic Foundation Catheter apparatus
JPH11514269A (en) 1995-10-13 1999-12-07 トランスバスキュラー インコーポレイテッド Methods and apparatus for bypassing arterial occlusion and / or performing other transvascular approaches
JPH11513577A (en) * 1995-10-13 1999-11-24 トランスバスキュラー インコーポレイテッド Apparatus, system and method for inter-tissue transluminal intervention
AU768005B2 (en) * 1998-03-31 2003-11-27 Transvascular, Inc. Tissue penetrating catheters having integral imaging transducers
DE60021330T2 (en) * 1999-01-06 2006-04-20 United States Surgical Corp., Norwalk Injection device for contrasting agents for tissue presentation
AU9654901A (en) * 2000-10-03 2002-04-15 Sutura Inc Fluid delivery and extraction device and method
ES2173042B1 (en) * 2001-02-28 2003-06-16 Lucas Victor Grifols Device and procedure for flow control for medicinal products.
ES2302827T5 (en) 2001-06-29 2016-03-16 Coloplast A/S Catheter and catheter manufacturing procedure
JP4229621B2 (en) * 2002-03-05 2009-02-25 修 加藤 Chemical injection catheter
JP4272905B2 (en) * 2003-03-06 2009-06-03 修 加藤 Chemical injection device
DE112004001398T5 (en) * 2003-07-29 2006-06-29 National Cancer Center Apparatus for the internal treatment of a patient and system for the internal treatment of a patient
EP1588731B1 (en) * 2004-04-20 2007-06-13 Bandula Wijay Local drug delivery catheter
CA2602662A1 (en) * 2005-03-30 2006-10-05 Lumend, Inc. Catheter systems for crossing total occlusions in vasculature
AU2006305967B2 (en) * 2005-10-27 2013-02-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Systems and methods for electrode contact assessment
JP2010500103A (en) * 2006-08-08 2010-01-07 ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド Catheters and arrays for anti-cancer treatment
AU2009208930A1 (en) * 2008-01-31 2009-08-06 Proteon Therapeutics, Inc. Medical device
NZ592912A (en) 2008-11-06 2013-08-30 Nxthera Inc Systems and methods for treatment of prostatic tissue
JP5800801B2 (en) * 2009-04-22 2015-10-28 マーケイター メドシステムズ， インコーポレイテッド Use of guanethidine to treat hypertension by local vascular delivery
CN105640501A (en) 2010-01-26 2016-06-08 迈克尔·A·埃文斯 denervation method, apparatus and medicine
US9237925B2 (en) * 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
CN103917200B (en) 2011-09-13 2016-03-30 恩克斯特拉公司 For the system and method for prostate treatment
WO2013123309A1 (en) 2012-02-15 2013-08-22 The Cleveland Clinic Foundation Catheter assembly and method of treating a vascular disease
JP5966709B2 (en) * 2012-07-17 2016-08-10 ニプロ株式会社 Trocar catheter, outer catheter used therefor, and inner needle
EP2877231A1 (en) * 2012-07-26 2015-06-03 Muffin Incorporated Multi-barrel syringe injection system
CN107243114A (en) 2012-11-21 2017-10-13 电路治疗公司 System and method for light genetic therapies
US20170216561A1 (en) * 2014-10-13 2017-08-03 Emory University Delivery Devices, Systems and Methods for Delivering Therapeutic Materials
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
BR112017019272A2 (en) 2015-03-10 2018-05-02 Allergan Pharmaceuticals Holdings Ireland Unlimited Company multiple needle injector
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
WO2017066262A1 (en) 2015-10-12 2017-04-20 Swaminathan Jayaraman System and method for delivery of a therapeutic agent through a catheter
EP3439716A1 (en) 2016-04-08 2019-02-13 Allergan, Inc. Aspiration and injection device
EP3515452A4 (en) 2016-09-22 2020-06-17 Mercator Medsystems, Inc. Treatment of restenosis using temsirolimus
RU177189U1 (en) * 2016-10-26 2018-02-12 Федеральное государственное автономное научное учреждение "Центральный научно-исследовательский и опытно-конструкторский институт робототехники и технической кибернетики" (ЦНИИ РТК) Device for entering and moving needles in soft tissues
CN110996687A (en) 2017-05-26 2020-04-10 墨卡托医疗系统公司 Combination therapy for the treatment of restenosis
EP3630006A1 (en) * 2017-06-01 2020-04-08 Biomedix SA Medical device and method of implanting gastroesophageal anti-reflux and obesity devices in an esophagus
US10500331B2 (en) * 2017-08-18 2019-12-10 Ayman H. Al-Jazaeri Drainage catheter with retractable internal drains
DE3344924A1 (en) * 1982-08-30 1985-06-13 James William Baumbach Catheter advance and placing unit
EP0323018A2 (en) * 1987-12-31 1989-07-05 United States Surgical Corporation Self-seating flapper valve for an insufflation cannula assembly
WO1991007196A1 (en) * 1989-11-17 1991-05-30 Masataka Saito Medical needle
DE3363716D1 (en) * 1982-04-14 1986-07-03 Dirk Alfons Augus Wildemeersch Device for the suprapubic drainage of the bladder introduced through the urethra
FR2609885B1 (en) * 1987-01-22 1989-04-14 Cassou Robert Instrument for artificial insemination, transfer of embryos or collection of follicular liquids from mammals
ES2075676T3 (en) * 1990-12-10 1995-10-01 Howmedica Device and procedure for the intersticial application of laser energy.
1995-04-20 NO NO951490A patent/NO951490D0/en not_active Application Discontinuation
AU2006255043B2 (en) * 2005-06-07 2013-01-17 David R. Staskin Injection guidance system and method
JP6054916B2 (en) 2016-12-27 Apparatus and method for treating an obstruction in a body lumen
US20150141952A1 (en) 2015-05-21 Needleless delivery systems
US20160206849A1 (en) 2016-07-21 Needleless injection device components, systems, and methods
AU738205B2 (en) 2001-09-13 Device for injecting fluid into a wall of a blood vessel
US20150112261A1 (en) 2015-04-23 Methods and devices for sensing tissues and tissue compartments
JP4988628B2 (en) 2012-08-01 Device for injecting liquid into the walls of blood vessels, body cavities, etc.
1994-04-28 OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law