Source: http://www.google.com/patents/US4743251?dq=4,923,986
Timestamp: 2017-10-22 23:47:10
Document Index: 355595338

Matched Legal Cases: ['art 18', 'art 20', 'art 20', 'art 20', 'art 20', 'art 20', 'art 20']

Patent US4743251 - Vein prothesis and method for producing same - Google Patents
The prothesis is intended to be implanted in a human patient for forming an aorto-coronary by-pass or another by-pass on other arteries. The prosthesis comprises a normal, unaltered living vein which is taken from the patient himself/herself and which is surrounded by a multiperforated flexible sheath....http://www.google.com/patents/US4743251?utm_source=gb-gplus-sharePatent US4743251 - Vein prothesis and method for producing same
Publication number US4743251 A
Application number US 06/708,425
Publication number 06708425, 708425, US 4743251 A, US 4743251A, US-A-4743251, US4743251 A, US4743251A
Inventors Jean-Aubert Barra
Original Assignee Henry Bocquee, Jacques Gardette
Patent Citations (6), Referenced by (156), Classifications (5), Legal Events (5)
Vein prothesis and method for producing same
US 4743251 A
The prothesis is intended to be implanted in a human patient for forming an aorto-coronary by-pass or another by-pass on other arteries. The prosthesis comprises a normal, unaltered living vein which is taken from the patient himself/herself and which is surrounded by a multiperforated flexible sheath. The inside diameter of the sheath is so chosen that, after implantation, the outside diameter of the vein is maintained by the sheath at a value less than the maximum possible diameter of the vein and that the inside diameter of the vein is suitable for the diameter of the receiver artery.
1. A method for producing a prothesis for implanting in a human patient so as to form a bypass or arteries such as aorto-coronary bypass, said prothesis comprising a living vein which is taken from the patient and a multi-perforated flexible sheath surrounding the vein, said method comprising taking a vein from the patient, surrounding said vein with a multi-perforated flexible sheath, said sheath having an inside diameter which is so chosen that, after implantation, said vein is constrained by said sheath so that its outside diameter is maintained by said sheath at a value less than the maximum possible diameter of said vein and that its inside diameter is substantially or very close to the receiver artery diameter.
(1) USE OF AN INTERNAL SUPPORT (FIG. 2A)
As shown in FIG. 2A, the sheath 7 formed by a cylindrical mesh is placed on a tube 8 having a very thin wall.
However it has been found that the mesh becomes distorted when it stays on the internal support more than 24 hours. Thus, its caliber increases and its length decreases, affecting the mesh efficiency. Therefore it is preferable that the mesh is not set on its internal support by the manufacturer. The surgeon should carry out this operation just before the vein is taken, so that the mesh stay on the internal support will be very short. For this purpose it is advantageous to use an internal support tube 31 as shown in FIG. 6A. The support tube 31 is cylindrical and has a conical tip 32 which is then cut. The thickness of the tube 31 should be as thin as possible order to introduce veins of various calibers. This thickness is preferably not over 0.20 mm. Such a tube may be obtained from rigid plastic materials such as rigid PVC, rigid polyurethane, polycarbonate or Teflon ®for example by injection moulding.
(2) USE OF A SUPPORT INCORPORATED IN THE SHEATH
(a) The perivascular sheath may be impregnated with a non-toxic, biodegradable, non-irritating substance which hardens upon drying. This substance must be soluble in a solvent satisfying the same criteria as the substance. The simplest example of a solvent is the physiological saline solution. Among the possible products may be mentioned glucose, saccharose, starch, macro-molecules, etc . . . The contact of the solvent or of the impregnation product must not alter the endothelium of the vein. The sheath impregnated with its stiffening product is dried in the shape of a tube so as to permit the insertion of the vein in the tubular sheath thus formed and allow it to slide along the longitudinal axis of the sheath. Several calibers of sheath are available to the surgeon. The stiffened sheath must be sterile and preserved under sterile conditions.
(3) EXTERNAL SUPPORT FOR THE SHEATH
In this case, the sheath is inside the support which may be a tube, three rods, two strips, a series of rings or a spiral. The sheath is secured to its support by a device which may be eliminated (for example overstitching). The sheath therefore remains open and the vein can be axially and longitudinally inserted therein.
(4) INTERNAL AND EXTERNAL SUPPORTS (FIG. 5)
As shown in FIG. 5 a first part 18 of the mesh is supported by an internal support tube 19 having a thin wall. A second part 20 is supported by two external supports 21. Each external support 21 comprises a ring which is connected to the second part 20 of the mesh by threads 22. The diameter of the second part 20 is the final diameter of the graft. Secured to the end of the vein 10 is a thread 23 which is inserted in the tube 19 and then in the second part 20 of the mesh. This thread 23 Is used for pulling the vein (in the direction of the arrow F). When the vein 10 is pulled through the second part 20 of the mesh, the diameter of this part tends to diminish, thus blocking the vein. By pulling the rings 21 in the opposite direction, the diameter of the part 20 is enlarged and the vein may be pulled again. When there is a new blocking of the vein, the rings 21 are again pulled in the opposite direction. In this way, the whole of the vein is inserted into the mesh step by step.
The animal experiment was carried out on four sheep.
In a new experiment on sheep, two groups of sheep were used. The group 1 (control group) included 6 jugular grafts according to the prior art. The group 2 included 8 jugular grafts surrounded by a mesh in accordance with the present invention. In group 1 the graft diameter was 15 mm±1 mm and in group 2 the graft diameter was 7 mm±0.5 mm. The veinous wall thickness in group 1 was twice greater than in group 2.
Right humero-radial bridging with a saphenous vein graft sheathed in a net or mesh having a diameter of 3.5 mm and a mesh size of 1 mm in a patient aged 25 years having a post-traumatic obliteration of the right cubito-radial arteries.
4 patients were given a saphenous graft surrounded by mesh system as on aorto-coronary by-pass. Previous saphenous diameters were 5 mm, 4.5, 3.5 and 3.5 mm. The meshes resulted in a graft diameter of 4, 3, 3.5, 2.8 and 2.5 mm respectively. Angiographic checking after 2 months show grafts of 4, 3 and 2.5 and 2.2 mm diameters, with a very regular caliber.
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Cooperative Classification A61F2/06, A61F2/064
Owner name: BOCQUEE, HENRY, 5, RUE WATER GROPIUS, 94523 RUNGIS
Free format text: ASSIGN TO EACH ASSIGNEE 1/3 INTEREST.;ASSIGNOR:BARRA, JEAN-AUBERT;REEL/FRAME:004383/0567
Owner name: GARDETTE, JACQUES, 5 RUE WALTER GROPIUS, 94523 RUN