Source: http://www.google.com/patents/US6026319?dq=5,598,374
Timestamp: 2014-03-13 11:11:46
Document Index: 761615133

Matched Legal Cases: ['art 10', 'art 11', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10', 'art 10']

Patent US6026319 - Fluorescence detecting system - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA fluorescence detecting system detects auto fluorescence emitted from an intrinsic pigment in a part of an organism. An excitation light projector intermittently projects onto the part excitation light in the wavelength range which can excite the intrinsic pigment of the organism to emit auto fluorescence....http://www.google.com/patents/US6026319?utm_source=gb-gplus-sharePatent US6026319 - Fluorescence detecting systemAdvanced Patent SearchPublication numberUS6026319 APublication typeGrantApplication numberUS 09/023,203Publication dateFeb 15, 2000Filing dateFeb 13, 1998Priority dateFeb 13, 1997Fee statusPaidPublication number023203, 09023203, US 6026319 A, US 6026319A, US-A-6026319, US6026319 A, US6026319AInventorsKatsumi HayashiOriginal AssigneeFuji Photo Film Co., Ltd.Export CitationBiBTeX, EndNote, RefManPatent Citations (12), Referenced by (13), Classifications (12), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetFluorescence detecting systemUS 6026319 AAbstract A fluorescence detecting system detects auto fluorescence emitted from an intrinsic pigment in a part of an organism. An excitation light projector intermittently projects onto the part excitation light in the wavelength range which can excite the intrinsic pigment of the organism to emit auto fluorescence. A fluorescence detector extracts an auto fluorescence component in a desired wavelength range from auto fluorescence emitted from the pigment. A net auto fluorescence component in the desired wavelength range is obtained by subtracting a base line component in the desired wavelength range the fluorescence detector detects when the part of the organism is not exposed to the excitation light from a gross auto fluorescence component in the desired wavelength range the fluorescence detector detects when the part of the organism is exposed to the excitation light. A divider carries out a division between a first part of the net auto fluorescence component in the desired wavelength range and a second part of the same.
The excitation light L1 of a wavelength λ.sub.ex is continuously emitted from the excitation light source 1a and intermittently projected onto the diagnostic part 10 including a diseased part 11 by the excitation light intermitting means 1a. Though the excitation light source 1a itself may be turned on and off without use of the excitation light intermitting means 1a, it is preferred from the viewpoint of the service life of the light source 1a and the like that the excitation light source 1a be kept on and the excitation light L1 be intermitted by the excitation light intermitting means 1a.
λ.sub.ex :the wavelength of the excitation light L1,
Iλ.sub.ex : the intensity of the excitation light L1 at the diagnostic part 10 which depends upon the distance L between the excitation light source 1a and the diagnostic part 10, the power P of the excitation light source 1a and the angle a at which the light bundle of the excitation light L1 impinges upon the diagnostic part 10, Iλ.sub.ex =Iλ.sub.ex (L, P, θ),
kλ.sub.3 : a constant which depends upon the wavelength λ.sub.ex of the excitation light L1 and the apparent density M of the auto fluorescence molecules which contribute to the whole visible auto fluorescence component,
ηFλ.sub.3 : the fluorescence quantum yield to the wavelength λ.sub.ex of the excitation light L1 of the auto fluorescence molecules which contribute to the whole visible auto fluorescence component,
I.sub.B1 : the base line component superimposed on the short wavelength component,
I.sub.B2 : the base line component superimposed on the long wavelength component,
I.sub.B3 : the base line component superimposed on the whole visible auto fluorescence component.
The short wavelength component Ifλ.sub.1 ' detected by the second fluorescence detecting means 4 when the diagnostic part 10 is exposed to the excitation light L1 is stored in the memory 6a and the long wavelength component Ifλ.sub.2 ' detected by the first fluorescence detecting means 3 when the diagnostic part 10 is exposed to the excitation light L1 is stored in the memory 5a. The short wavelength component Ifλ.sub.1 " detected by the second fluorescence detecting means 4 when the diagnostic part 10 is not exposed to the excitation light L1 is stored in the memory 6b and the long wavelength component Ifλ.sub.2 " detected by the first fluorescence detecting means 3 when the diagnostic part 10 is not exposed to the excitation light L1 is stored in the memory 5b.
The apparent short wavelength component Ifλ.sub.1 ' when the diagnostic part 10 is exposed to the excitation light L1:
If&#955;.sub.1 '=k&#955;.sub.1  The apparent long wavelength range component Ifλ.sub.2 ' when the diagnostic part 10 is exposed to the excitation light L1:
If&#955;.sub.2 ' =k&#955;.sub.2  The apparent short wavelength component Ifλ.sub.1 " when the diagnostic part 10 is not exposed to the excitation light Li:
If&#955;.sub.1 "=I.sub.B1.
The apparent long wavelength range component Ifλ.sub.2 " when the diagnostic part 10 is not exposed to the excitation light L1: Ifλ.sub.2 "=I.sub.B2.
The subtracter 6c subtracts the apparent short wavelength component Ifλ.sub.1 " when the diagnostic part 10 is not exposed to the excitation light L1 from the apparent short wavelength component Ifλ.sub.1 ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net short wavelength component Ifλ.sub.1. The net short wavelength component ifλ.sub.1 is represented as follows.
If&#955;.sub.1 =k&#955;.sub.1  The subtracter Sc subtracts the apparent long wavelength component Ifλ.sub.2 " when the diagnostic part 10 is not exposed to the excitation light L1 from the apparent long wavelength component Ifλ.sub.2 ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net long wavelength component Ifλ.sub.2. The net short wavelength component Ifλ.sub.2 is represented as follows.
If&#955;.sub.2 =k&#955;.sub.2  Then the divider means 7 divides the net short wavelength component Ifλ.sub.1 by the net long wavelength component Ifλ.sub.2. That is,
If&#955;.sub.2 /If&#955;.sub.1 =(k&#955;.sub.2  By this division, the term depending on the distance between the excitation light source 1a and the diagnostic part 10 is cancelled. In the manner described above, the intensity of fluorescence can be effectively corrected even there is a base line component.
If&#955;.sub.2 ' =k&#955;.sub.2  Accordingly, the sum fluorescence component Ifλ' of the short wavelength component and the long wavelength component when the diagnostic part 10 is exposed to the excitation light L1 is represented as follows.
If&#955;'=(k&#955;.sub.1     +I.sub.B2.
The apparent short wavelength component Ifλ.sub.1 " when the diagnostic part 10 is not exposed to the excitation light L1:
If&#955;.sub.1 "=I.sub.B1 +I.sub.B2.
The subtracter 6c subtracts the apparent short wavelength component Ifλ.sub.1 ' when the diagnostic part 10 is not exposed to the excitation light L1 from the apparent short wavelength component Ifλ.sub.1 ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net short wavelength component Ifλ.sub.1. The net short wavelength component Ifλ.sub.1 is represented as follows.
If&#955;.sub.1 =k&#955;.sub.1  The subtracter 5c subtracts the sum fluorescence component Ifλ" when the diagnostic part 10 is not exposed to the excitation light L1 from the sum fluorescence component Ifλ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net sum fluorescence component Ifλ. The net sum fluorescence component Ifλ is represented as follows.
If&#955;=(k&#955;.sub.1    Then the divider means 7 divides the net short wavelength component Ifλ.sub.1 by the net sum fluorescence component Ifλ/(Ifλ.sub.1 +Ifλ.sub.2) That is,
If&#955;/(If&#955;.sub.1 +If&#955;.sub.2)=(k&#955;.sub.1    By this division, the term depending on the distance between the excitation light source 1a and the diagnostic part 10 is cancelled. In the manner described above, the intensity of fluorescence can be effectively corrected even there is a base line component.
If&#955;.sub.1 '=k&#955;.sub.1  The apparent whole visible auto fluorescence component Ifλ.sub.3 ' when the diagnostic part 10 is exposed to the excitation light L1:
If&#955;.sub.3 '=k&#955;.sub.3  The apparent short wavelength component Ifλ.sub.1 " when the diagnostic part 10 is not exposed to the excitation light L1:
The apparent whole visible auto fluorescence component Ifλ.sub.3 " when the diagnostic part 10 is not exposed to the excitation light L1:
If&#955;.sub.3 "=I.sub.B3.
The subtracter 5c subtracts the apparent short wavelength component Ifλ.sub.1 " when the diagnostic part 10 is not exposed to the excitation light L1 from the apparent short wavelength component Ifλ.sub.1 ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net short wavelength component Ifλ.sub.1. The net short wavelength component Ifλ.sub.1 is represented as follows.
If&#955;.sub.1 =k&#955;.sub.1  The subtracter 6c subtracts the whole visible auto fluorescence component Ifλ.sub.3 " when the diagnostic part 10 is not exposed to the excitation light L1 from the whole visible auto fluorescence component Ifλ.sub.3 ' when the diagnostic part 10 is exposed to the excitation light L1 and obtains a net whole visible auto fluorescence component Ifλ.sub.3. The net whole visible auto fluorescence component Ifλ.sub.3 is represented as follows.
If&#955;.sub.3 =k&#955;.sub.3  Then the divider means 7 divides the net short wavelength component Ifλ.sub.1 by the net whole visible auto fluorescence component Ifλ.sub.1 /Ifλ.sub.3. That is,
If&#955;.sub.1 /If&#955;.sub.3 =(k&#955;.sub.1  By this division, the term depending on the distance between the excitation light source 1a and the diagnostic part 10 is cancelled. In the manner described above, the intensity of fluorescence can be effectively corrected even there is a base line component.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4768513 *Mar 30, 1987Sep 6, 1988Agency Of Industrial Science And TechnologyMethod and device for measuring and processing lightUS5042494 *Dec 4, 1989Aug 27, 1991Alfano Robert RMethod and apparatus for detecting cancerous tissue using luminescence excitation spectraUS5348018 *Nov 25, 1991Sep 20, 1994Alfano Robert RMethod for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopyUS5456252 *Sep 30, 1993Oct 10, 1995Cedars-Sinai Medical CenterInduced fluorescence spectroscopy blood perfusion and pH monitor and methodUS5467767 *Aug 27, 1993Nov 21, 1995Alfano; Robert R.Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopyUS5507287 *Apr 27, 1995Apr 16, 1996Xillix Technologies CorporationEndoscopic imaging system for diseased tissueUS5590660 *Mar 28, 1994Jan 7, 1997Xillix Technologies Corp.Apparatus and method for imaging diseased tissue using integrated autofluorescenceUS5647368 *Feb 28, 1996Jul 15, 1997Xillix Technologies Corp.Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tractUS5769792 *Apr 15, 1996Jun 23, 1998Xillix Technologies Corp.Endoscopic imaging system for diseased tissueUS5827190 *Aug 19, 1996Oct 27, 1998Xillix Technologies Corp.Endoscope having an integrated CCD sensorUS5833617 *Mar 6, 1997Nov 10, 1998Fuji Photo Film Co., Ltd.Fluorescence detecting apparatusUS5849595 *Oct 2, 1995Dec 15, 1998Alfano; Robert R.Method for monitoring the effects of chemotherapeutic agents on neoplasmic media* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6256530 *Sep 15, 1998Jul 3, 2001Denvu, L.L.C.Optical instrument and technique for cancer diagnosis using in-vivo fluorescence emission of test tissueUS6571118 *May 4, 1999May 27, 2003Board Of Regents, The University Of Texas SystemCombined fluorescence and reflectance spectroscopyUS6615063 *Nov 27, 2000Sep 2, 2003The General Hospital CorporationFluorescence-mediated molecular tomographyUS6970246Apr 11, 2001Nov 29, 2005Chemometec A/SMethod and apparatus for detecting fluorescence of a sampleUS7383076May 22, 2003Jun 3, 2008The General Hospital CorporationFluorescence-mediated molecular tomographyUS7647091Feb 5, 2004Jan 12, 2010The General Hospital CorporationMethod and system for free space optical tomography of diffuse mediaUS7684056 *Jul 23, 2007Mar 23, 2010Nissan Motor Co., Ltd.Light detecting method and light detecting apparatusUS7962200Dec 7, 2009Jun 14, 2011The General Hospital CorporationMethod and system for free space optical tomography of diffuse mediaUS8170651Jan 15, 2010May 1, 2012Visen Medical, Inc.Imaging volumes with arbitrary geometries in non-contact tomographyUS8190241May 23, 2008May 29, 2012The General Hospital CorporationFluorescence-mediated molecular tomographyUS8326406May 3, 2011Dec 4, 2012The General Hospital CorporationMethod and system for free space optical tomography of diffuse mediaUS8486373Nov 1, 2004Jul 16, 2013The General Hospital CorporationIntramolecularly-quenched near infrared fluorescent probesUS8617057 *May 16, 2007Dec 31, 2013Olympus CorporationEndoscope system* Cited by examinerClassifications U.S. Classification600/476, 600/478International ClassificationA61B1/00, A61B1/04, A61B5/00Cooperative ClassificationA61B1/0638, A61B1/043, A61B1/00009, A61B5/0071, A61B5/0084European ClassificationA61B5/00P12B, A61B5/00P5Legal EventsDateCodeEventDescriptionJul 13, 2011FPAYFee paymentYear of fee payment: 12Jul 20, 2007FPAYFee paymentYear of fee payment: 8Feb 15, 2007ASAssignmentOwner name: FUJIFILM CORPORATION, JAPANFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FUJIFILM HOLDINGS CORPORATION (FORMERLY FUJI PHOTO FILM CO., LTD.);REEL/FRAME:018904/0001Effective date: 20070130Owner name: FUJIFILM CORPORATION,JAPANFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FUJIFILM HOLDINGS CORPORATION (FORMERLY FUJI PHOTO FILM CO., LTD.);US-ASSIGNMENT DATABASE UPDATED:20100525;REEL/FRAME:18904/1Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FUJIFILM HOLDINGS CORPORATION (FORMERLY FUJI PHOTO FILM CO., LTD.);REEL/FRAME:18904/1Jul 21, 2003FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google