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Patent US6295514 - Method, system, and computer program product for representing similarity ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA system method, and computer program product for visualizing and interactively analyzing data relating to chemical compounds. A user selects a plurality of compounds to map, and also selects a method for evaluating similarity/dissimilarity between the selected compounds. A non-linear map is generated...http://www.google.com/patents/US6295514?utm_source=gb-gplus-sharePatent US6295514 - Method, system, and computer program product for representing similarity/dissimilarity between chemical compoundsAdvanced Patent SearchPublication numberUS6295514 B1Publication typeGrantApplication numberUS 08/963,872Publication dateSep 25, 2001Filing dateNov 4, 1997Priority dateNov 4, 1996Fee statusPaidAlso published asCA2269669A1, CA2270527A1, EP0935784A2, EP0935789A1, US6421612, US7188055, US20020069043, US20030014191, WO1998020437A2, WO1998020437A3, WO1998020459A1Publication number08963872, 963872, US 6295514 B1, US 6295514B1, US-B1-6295514, US6295514 B1, US6295514B1InventorsDimitris K. Agrafiotis, Victor S. Lobanov, Francis R. SalemmeOriginal Assignee3-Dimensional Pharmaceuticals, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (72), Non-Patent Citations (150), Referenced by (47), Classifications (40), Legal Events (5) External Links: USPTO, USPTO Assignment, EspacenetMethod, system, and computer program product for representing similarity/dissimilarity between chemical compoundsUS 6295514 B1Abstract A system method, and computer program product for visualizing and interactively analyzing data relating to chemical compounds. A user selects a plurality of compounds to map, and also selects a method for evaluating similarity/dissimilarity between the selected compounds. A non-linear map is generated in accordance with the selected compounds and the selected method. The non-linear map has a point for each of the selected compounds, wherein a distance between any two points is representative of similarity/dissimilarity between the corresponding compounds. A portion of the non-linear map is then displayed. Users are enabled to interactively analyze compounds represented in the non-linear map.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4773099Oct 10, 1985Sep 20, 1988The Palantir CorporationPattern classification means for use in a pattern recognition systemUS4811217Mar 25, 1986Mar 7, 1989Japan Association For International Chemical InformationMethod of storing and searching chemical structure dataUS4859736Mar 21, 1988Aug 22, 1989Ciba-Geigy CorporationSynthetic polystyrene resin and its use in solid phase peptide synthesisUS4908773Apr 6, 1987Mar 13, 1990Genex CorporationComputer designed stabilized proteins and method for producing sameUS4935875Feb 13, 1989Jun 19, 1990Data Chem, Inc.Chemical analyzerUS4939666Sep 2, 1987Jul 3, 1990Genex CorporationIncremental macromolecule construction methodsUS5010175May 2, 1988Apr 23, 1991The Regents Of The University Of CaliforniaReacting activated amino acids with an acceptor amino acid or peptide in relative concentrations based on relative coupling constants so that the resulting mixture of peptides contains each peptide in predictable amountsUS5025388Aug 26, 1988Jun 18, 1991Cramer Richard D IiiComparative molecular field analysis (CoMFA)US5155801Oct 9, 1990Oct 13, 1992Hughes Aircraft CompanyClustered neural networksUS5167009Aug 3, 1990Nov 24, 1992E. I. Du Pont De Nemours & Co. (Inc.)On-line process control neural network using data pointersUS5181259Sep 25, 1990Jan 19, 1993The United States Of America As Represented By The Administrator Of The National Aeronautics And Space AdministrationGeneral method of pattern classification using the two domain theoryUS5240680Dec 19, 1991Aug 31, 1993Chiron CorporationAutomated apparatus for use in peptide synthesisUS5260882Jan 2, 1991Nov 9, 1993Rohm And Haas CompanyProcess for the estimation of physical and chemical properties of a proposed polymeric or copolymeric substance or materialUS5265030Aug 19, 1992Nov 23, 1993Scripps Clinic And Research FoundationSystem and method for determining three-dimensional structures of proteinsUS5270170Oct 16, 1991Dec 14, 1993Affymax Technologies N.V.Peptide library and screening methodUS5288514Sep 14, 1992Feb 22, 1994The Regents Of The University Of CaliforniaLinking a protected 2-aminobenzophenone to a substrate; deprotecting and reacting with an amino acid; cyclization; removal from substrate; screeningUS5307287Jun 17, 1991Apr 26, 1994Tripos Associates, Inc.Comparative molecular field analysis (COMFA)US5323471Mar 30, 1992Jun 21, 1994Atr Auditory And Visual Perception Research LaboratoriesPattern recognition apparatus and pattern learning apparatus employing neural net including excitatory element-inhibitory element pair couplingsUS5331573Dec 14, 1990Jul 19, 1994Balaji Vitukudi NMethod of design of compounds that mimic conformational features of selected peptidesUS5434796Jun 30, 1993Jul 18, 1995Daylight Chemical Information Systems, Inc.Method and apparatus for designing molecules with desired properties by evolving successive populationsUS5436850Mar 28, 1994Jul 25, 1995The Regents Of The University Of CaliforniaMethod to identify protein sequences that fold into a known three-dimensional structureUS5442122Nov 3, 1993Aug 15, 1995Shimadzu CorporationDibenzosuberyl and dibenzosuberenyl derivativesUS5463564Sep 16, 1994Oct 31, 19953-Dimensional Pharmaceuticals, Inc.System and method of automatically generating chemical compounds with desired propertiesUS5499193Jun 21, 1993Mar 12, 1996Takeda Chemical Industries, Ltd.Automated synthesis apparatus and method of controlling the apparatusUS5519635Sep 6, 1994May 21, 1996Hitachi Ltd.Apparatus for chemical analysis with detachable analytical unitsUS5524065Jul 25, 1994Jun 4, 1996Canon Kabushiki KaishaMethod and apparatus for pattern recognitionUS5526281Oct 28, 1994Jun 11, 1996Arris Pharmaceutical CorporationMachine-learning approach to modeling biological activity for molecular design and to modeling other characteristicsUS5545568Dec 2, 1993Aug 13, 1996The Regents Of The University Of CaliforniaSolid phase and combinatorial synthesis of compounds on a solid supportUS5549974Jun 23, 1994Aug 27, 1996Affymax Technologies NvImmobilizationUS5553225Oct 25, 1994Sep 3, 1996International Business Machines CorporationMethod and apparatus for combining a zoom function in scroll bar slidersUS5565325Jun 1, 1995Oct 15, 1996Bristol-Myers Squibb CompanyIterative methods for screening peptide librariesUS5574656Sep 28, 1995Nov 12, 19963-Dimensional Pharmaceuticals, Inc.System and method of automatically generating chemical compounds with desired propertiesUS5585277Mar 21, 1995Dec 17, 1996Scriptgen Pharmaceuticals, Inc.Determining ability of test ligands to increase the ratio of folded target protein to unfolded target protein; testing for possible pharmaceutical effectivenessUS5602755Jun 23, 1995Feb 11, 1997Exxon Research And Engineering CompanyMethod for predicting chemical or physical properties of complex mixturesUS5602938May 20, 1994Feb 11, 1997Nippon Telegraph And Telephone CorporationMethod of generating dictionary for pattern recognition and pattern recognition method using the sameUS5612895Apr 21, 1995Mar 18, 1997Balaji; Vitukudi N.Method of rational drug design based on ab initio computer simulation of conformational features of peptidesUS5634017Jun 21, 1996May 27, 1997International Business Machines CorporationComputer system and method for processing atomic data to calculate and exhibit the properties and structure of matter based on relativistic modelsUS5635598Jun 21, 1994Jun 3, 1997Selectide CorporationSelectively cleavabe linners based on iminodiacetic acid esters for solid phase peptide synthesisUS5670326Jun 7, 1995Sep 23, 1997Pharmagenics, Inc.Reiterative method for screening combinatorial librariesUS5679582Jun 21, 1994Oct 21, 1997Scriptgen Pharmaceuticals, Inc.Screening method for identifying ligands for target proteinsUS5684711Aug 15, 1996Nov 4, 19973-Dimensional Pharmaceuticals, Inc.System, method, and computer program for at least partially automatically generating chemical compounds having desired propertiesUS5703792Dec 13, 1994Dec 30, 1997Arris Pharmaceutical CorporationThree dimensional measurement of molecular diversityUS5712171Jan 20, 1995Jan 27, 1998Arqule, Inc.Method of generating a plurality of chemical compounds in a spatially arranged arrayUS5712564Dec 29, 1995Jan 27, 1998Unisys CorporationMagnetic ink recorder calibration apparatus and methodUS5736412May 17, 1996Apr 7, 1998Arqule, Inc.Method of generating a plurality of chemical compounds in a spatially arranged arrayUS5740326Jun 7, 1995Apr 14, 1998International Business Machines CorporationCircuit for searching/sorting data in neural networksUS5789160Jun 5, 1995Aug 4, 1998Nexstar Pharmaceuticals, Inc.Parallel selexUS5807754May 11, 1995Sep 15, 1998Arqule, Inc.Combinatorial synthesis and high-throughput screening of a Rev-inhibiting arylidenediamide arrayUS5811241Sep 13, 1995Sep 22, 1998Cortech, Inc.Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinedionesUS5832494 *May 17, 1996Nov 3, 1998Libertech, Inc.Method and apparatus for indexing, searching and displaying dataUS5858660Mar 20, 1996Jan 12, 1999Nexstar Pharmaceuticlas, Inc.Parallel selexUS5861532Mar 4, 1997Jan 19, 1999Chiron CorporationSolid-phase synthesis of N-alkyl amidesUS5866334Jul 16, 1996Feb 2, 1999Genzyme CorporationDetermination and identification of active compounds in a compound libraryUS5901069Aug 1, 1997May 4, 19993-Dimensional Pharmaceuticals, Inc.System, method, and computer program product for at least partially automatically generating chemical compounds with desired properties from a list of potential chemical compounds to synthesizeUS5908960Apr 27, 1998Jun 1, 1999Smithkline Beecham CorporationLibraries of compounds based upon a n-benzyl-n-alkyl-4-alkoxybenzamide, n-benzyl-n-alkyl-4-alkoxyphenylacetamide and n-benzyl-n-alkyl-3-(4-alkoxyphenyl)propionamide template toUS5933819May 23, 1997Aug 3, 1999The Scripps Research InstituteComputer-implemented methodUS6014661May 2, 1997Jan 11, 2000Ivee Development AbSystem and method for automatic analysis of data bases and for user-controlled dynamic queryingUS6037135Nov 29, 1993Mar 14, 2000Epimmune Inc.Methods for making HLA binding peptides and their usesUS6049797Apr 7, 1998Apr 11, 2000Lucent Technologies, Inc.Method, apparatus and programmed medium for clustering databases with categorical attributesEP0355266B1Apr 27, 1989Jun 9, 1993Millipore CorporationApparatus for performing repetitive chemical reactionsEP0355628B1Aug 11, 1989Nov 10, 1993Siemens AktiengesellschaftProcess for chemically decontaminating the surface of a metallic construction element of a nuclear power plantEP0770876A1Oct 17, 1996May 2, 1997Scriptgen Pharmaceuticals, Inc.A screening method for identifying ligands for target proteinsEP0818744A2Jun 24, 1997Jan 14, 1998Proteus Molecular Design LimitedProcess for selecting candidate drug compoundsWO1991019735A1Jun 14, 1991Dec 15, 1991Paul A BartlettLibraries of modified peptides with protease resistanceWO1992000091A1Jul 1, 1991Jan 9, 1992Bioligand IncRandom bio-oligomer library, a method of synthesis thereof, and a method of use thereofWO1993020242A1Mar 30, 1993Oct 14, 1993Sydney BrennerEncoded combinatorial chemical librariesWO1994028504A1May 20, 1994Dec 8, 1994Arris PharmaceuticalA machine-learning approach to modeling biological activity for molecular design and to modeling other characteristicsWO1995001606A1Jun 29, 1994Jan 12, 1995Daylight Chem Inf Syst IncMethod and apparatus for designing molecules with desired properties by evolving successive populationsWO1997009342A1Sep 6, 1996Mar 13, 1997Scriptgen Pharm IncScreen for compounds with affinity for rnaWO1997020952A1Dec 6, 1996Jun 12, 1997Scriptgen Pharm IncA fluorescence-based screening method for identifying ligandsWO1997027559A1Jan 27, 1997Jul 31, 1997David E PattersonMethod of creating and searching a molecular virtual library using validated molecular structure descriptorsWO1998020459A1Nov 4, 1997May 14, 1998Dimensional Pharm IncSystem, method, and computer program product for the visualization and interactive processing and analysis of chemical data* Cited by examinerNon-Patent CitationsReference1"3DP gains drug research patent", Source of publication unclear, vol. 32, No. 1, Jan. 1996, 2 pages.2"Accelerate the Discovery Cycle with Chem-X!", Source and date of publicaton nuclear, 2 pages.3"ArQule Inc", from http://www.bioportfolio.com/arqule/products.htm, 5 pages, (Mar. 18, 1998).4Agrafiotis, D. K., et al., "Stochastic Algorithms for Maximizing Molecular Diversity", Journal of Chemical Information and Computer Sciences, vol. 37, pp. 841-851, (1997).5Agrafiotis, D., "Theoretical Aspects of the Complex: Arts and New Technologies," Applications and Impacts Information Processing '94, vol. II, 1994, pp. 714-719.6Agrafiotis, D.K. and Jaeger, E.P., "Directed Diversity(R): An Operating System For Combinatorial Chemistry," Abstracts of Papers Part 1: 211th ACS National Meeting, Mar. 24-28, 1996, p. 46-COMP.7Agrafiotis, D.K. and Jaeger, E.P., "Stochastic Algorithms for Exploring Molecular Diversity," Abstracts of Papers Part 1: 213th ACS National Meeting, Apr. 13-17, 1997, p. 16-CINF.8Agrafiotis, D.K. and Jaeger, E.P., "Directed Diversity�: An Operating System For Combinatorial Chemistry," Abstracts of Papers Part 1: 211th ACS National Meeting, Mar. 24-28, 1996, p. 46-COMP.9Agrafiotis, D.K. and Lobanov, V.S., "An Efficient Implementation of Distance-Based Diveristy Measure based on k-d Trees," J. Chem. Inf. Comput. Sci., vol. 39, No. 1, Jan./Feb. 1999, pp. 51-58.10Agrafiotis, D.K. and Lobanov, V.S., "Bridging The Gap Between Diversity and QSAR," Abstracts of Papers Part 1: 215th ACS National Meeting, Mar. 29-Apr. 2, 1998, p. 181-COMP.11Agrafiotis, D.K. et al., "Advances in diversity profiling and combinatorial series design," Molecular Diversity, vol. 4, 1999, pp. 1-22.12Agrafiotis, D.K. et al., "Parallel QSAR," Abstracts of Papers Part 1: 217th ACS National Meeting, Mar. 21-25, 1999, p. 50-COMP.13Agrafiotis, D.K. et al., "PRODEN: A New Program for Calculating Integrated Projected Populations," Journal of Computational Chemistry, vol. 11, No. 9, Oct. 1990, pp. 1101-1110.14Agrafiotis, D.K., "A New Method For Analyzing Protein Sequence Relationships Based On Sammon Maps," Protein Science, vol. 6, No. 2, Feb. 1997, pp. 287-293.15Agrafiotis, D.K., "Diversity of Chemical Libraries," Encyclopedia of Computational Chemistry, vol. 1:A-D, 1998, pp. 742-761.16Agrafiotis, D.K., "On the Use of Information Theory for Assessing Molecular Diversity," J. Chem. Inf. Comput. Sci., vol. 37, No. 3, May/Jun. 1997, pp. 576-580.17Alsberg, B.K. et al., "Classification of pyrolysis mass spectra by fuzzy multivariate rule induction-comparison with regression, K-nearest neighbour, neural and decision-tree methods", Analytica Chimica Acta, vol. 348, No. 1-3, pp. 389-407, (Aug. 20, 1997).18Amzel, L.M., "Structure-based drug design," Current Opinion in Biotechnology, vol. 9, No. 4, Aug. 1998, pp. 366-369.19Andrea, T.A. et al., "Applications of Neural Networks in Quantitative Structure-Activity Relationships of Dihydrofolate Reductase Inhibitors", Journal of Medicinal Chemistry, vol. 34, No. 9, pp. 2824-2836, (1991).20Aoyama, T. and Hiroshi Ichikawa, "Obtaining the Correlation Indices between Drug Activity and Structural Parameters Using a Neural Network", Chemical & Pharmaceutical Bulletin, vol. 39, No. 2, pp. 372-378, (1991).21Aoyama, T. et al., "Neural Networks Applied to Quantitative Structure-Activity Relationship Analysis", Journal of Medicinal Chemistry, vol. 33, No. 9, pp. 2583-2590, (1990).22Appl. No. 08/963,870 Agrafiotis et al. Nov. 4, 1997.23Appl. No. 09/073,845 Agrafiotis et al. May, 7, 1998.24Appl. No. 09/303,671 Agrafiotis et al. May 3, 1999.25Barnard, John M. and Downs, Geoff M., "Computer representation and manipulation of combinatorial libraries," Perspectives in Drug Discovery and Design, 1997, pp. 13-30.26Baum, R.M., "Combinatorial Approaches Provide Fresh Leads for Medicinal Chemistry", Chemical & Engineering News, Feb. 7, 1994, (pp. 20-26).27Bentley, J. L., "Multidimensional Binary Search Trees Used for Associative Searching" Communications of the ACM, vol. 18, No. 9, pp. 509-517, (Sep. 1975).28Biswas, G. et al., "Evaluation of Projection Algorithms," IEEE Transactions On Pattern Analysis And Machine Intellignece, vol. PAMI-3, No. 6, Nov. 1981, pp. 701-708.29Blaney, J.M. and Martin, E.J., "Computational approaches for combinatorial library design and molecular diversity analysis," Current Opinion in Chemical Biology, vol. 1, No. 1, Jun. 1997. pp. 54-59.30Bonchev, D. and Trinajsti&cacute;, N., "Information theory, distance matrix, and molecular branching," The Journal of Chemical Physics, vol. 67, No. 10, Nov. 15, 1977, pp. 4517-4533.31Bonchev, D. and Trinajstić, N., "Information theory, distance matrix, and molecular branching," The Journal of Chemical Physics, vol. 67, No. 10, Nov. 15, 1977, pp. 4517-4533.32Borg, Inger and Groenen, Patrick, Modern Multidimensional Scaling Theory and Applications, Springer Series in Statistics, 1997, entire book submitted.33Bottou, L. and Vladimir Vapnik, "Local Learning Algorithm", Neural Computation, vol. 4, No. 6, pp. 888-900, (Nov. 1992).34Boulu, L.G. and Gordon M. Crippen, "Voronoi Binding Site Models: Calculation of Binding Modes and Influence of Drug Binding Data Accuracy", Journal of Computational Chemistry, vol. 10, No. 5, pp. 673-682, (1989).35Boulu, L.G. et al., "Voronoi Binding Site Model of a Polycyclic Aromatic Hydrocarbon Binding Protein", Journal of Medicinal Chemistry, vol. 33, No. 2, pp. 771-775, (1990).36Brint, Andrew T. and Willett, Peter, "Upperbound procedures for the identification of similar three-dimensional chemical structures," Journal of Computer-Aided Molecular Design, vol. 2, No. 4, 1988, pp. 311-320.37Brown, R. D. and Yvonne C. Martin, "Use of Structure-Activitity Data To Compare Structure-Based Clustering Methods and Descriptors for Use in Compound Selection", Journal of Chemical Information and Computer Sciences, vol. 36, No. 3, pp. 572-584, (1996).38Brown, R.D. and Clark, D.E., "Genetic diversity: applications of evolutionary algorithms to combinatorial library design," Expert Opinion on Therapeutic Patents, vol. 8, No. 11, Nov. 1998, pp. 1447-1459.39Brown, Robert D. and Martin, Yvonne C., "Designing Combinatorial Library Mixtures Using a Genetic Algorithm" Journal of Medicinal Chemistry, vol. 40, No. 15, 1997, pp. 2304-2313.40Cacoullos, T., "Estimation of a Multivariate Density", Annals of The Institute of Statistical Mathematics, vol. 18, No. 2, pp. 179-189, (1966).41Caflisch, A. and Karplus, M., "Computational combinatorial chemistry for de novo ligand design: Review and assessment," Perspectives in Drug Discovery and Design, vol. 3, 1995, pp. 51-84.42Chang, C.L. and Lee, R.C.T., "A Heuristic Relaxation Method for Nonlinear Mapping in Cluster Analysis," IEEE Transactions on Systems, Man, and Cybernetics, vol. SMC-3, Mar. 1973, pp. 197-200.43Clark, D. E., and David R. Westhead, "Evolutionary algorithms in computer-aided molecular design", Journal of Computer-Aided Molecular Design, vol. 10, No. 4, pp. 337-358, (Aug. 1996).44Clark, R.D., "OptiSim: An Extended Dissimilarity Selection Method for Finding Diverse Representative Subsets", Journal of Chemical Information and Computer Sciences. vol. 37, No. 6, pp. 1181-1188 (12 Page Internet printout), 1997.45Copy of International Search Report issued Apr. 21, 1998 for PCT/US97/20919.46Copy of International Search Report issued May 13, 1998 for PCT/US97/20918.47Cramer, R. D. III et al., "Comparative Molecular Field Analyisis (CoMFA). 1. Effect of Shape on Binding of Steroids to Carrier Proteins", Journal of The American Chemical Society, vol. 110, No. 18, pp. 5959-5967, (Aug. 31, 1988).48Cramer, R. D. III et al., "Substructural Analysis. A Novel Approach to the Problem of Drug Design", Journal of Medicinal Chemistry, vol. 17, No. 5, pp. 533-535, (May 1974).49Cramer, R.D. et al., "Virtual Compound Libraries: A New Approach to Decision Making in Molecular Discovery Research," J. Chem. Inf. Comput. Sci., vol. 38, No. 6, Nov./Dec. 1998, pp. 1010-1023.50Crippen, G. M., "Voronoi binding Site Models", Journal of Computational Chemistry, vol. 8, No. 7, pp. 943-955, (Oct./Nov. 1987).51Danheiser, S.L., "Current Trends in Synthetic Peptide and Chemical Diversity Library Design," Genetic Engineering News, May 1, 1994, pp. 10 and 31.52DeMers, D. and Cottrell, G., "Non-Linear Dimensionality Reduction," Advances in Neural Information Processing Systems, vol. 5, 1993, pp. 580-587.53Eichler, U. et al., "Addressing the problem of molecular diversity," Drugs of the Future, vol. 24, No. 2, 1999, pp. 177-190.54Felder, E.R. and Poppinger, D., "Combinatorial Compound Libraries for Enhanced Drug Discovery Approaches," Advances in Drug Research, vol. 30, 1997, pp. 112-199.55Frey, P.W. and Slate, D.J., "Letter Recognition Using Holland-Style Adaptive Classifiers," Machine Learning, vol. 6, 1991, pp. 161-182.56Friedman, J. H. et al., "An Algorithm for Finding Best Matches in Logarithmic Expected Time", ACM Transactions on Mathematical Software, vol. 3, No. 3, pp. 209-226, (Sep. 1977).57Friedman, J.H. and Tukey, J.W., "A Projection Pursuit Algorithm for Exploratory Data Analysis," IEEE Transcations on Computers, vol. C-23, No. 9, Sep. 1974, pp. 881-889.58Friedman, J.H., "Exploratory Projection Pursuit," Journal of the American Statistical Association, vol. 82, No. 397, Mar. 1987, pp. 249-266.59Friedman, J.H., "Fitting Functions To Noisy Data In High Dimensions", Department of Statistics-Stanford University Technical Report No. 101, (Aug., 1988).60Gallop, M. A. et al., "Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries", Journal of Medicinal Chemistry, vol. 37, No. 9, pp. 1233-1251, (Apr. 29, 1994).61Garrido, L. et al., "Use of Multilayer Feedforward Neural Nets As A Display Method for Multidimensional Distributions," International Journal of Neural Systems, vol. 6, No. 3, Sep. 1995, pp. 273-282.62Gasteiger et al, "Assessment of the Diversity of Combinatorial Libraries by an Encoding of Molecular Surface Properties", Abstracts of Papers, American Chemical Society, 211th ACS National Meeting, Item 070, Mar. 1996.*63Gasteiger, J. et al., "Analysis of the Reactivity of Single Bonds in Aliphatic Molecules by Statistical and Pattern Recognition Methods," Journal of Chemical Information Computer Science, vol. 33, No. 3, 1993, pp. 385-394.64Geysen, H.M. and Mason, T.J., "Screening Chemically Synthesized Peptide Libraries for Biologically-Relevant Molecules," Biorganic & Medicinal Chemistry Letters, vol. 3, No. 3, 1993, pp. 397-404.65Ghose, A. K. and Gordon M. Crippen, "Use of Physicochemical Parameters in Distance Geometry and Related Three-Dimensional Qantitative Structure-Activity Relationships: A Demonstration Using Escherichia coli Dihydrofolate Reductase Inhibitors", Journal of Medicinal Chemistry, vol. 28, No. 3, pp. 333-346, (1985).66Ghose, A.K. et al., "Prediction of Hydrophobic (Liphophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods," J. Phys. Chem. A, vol. 102, No. 21, May 21, 1998, pp. 3762-3772.67Gillet, Valerie J. et al., "Selecting Combinatorial Libraries to Optimize Diversity and Physical Properties," Journal of Chemical Information Computer Sciences, vol. 39, No. 1, 1999, pp. 169-177.68Gillet, Valerie J. et al., "The Effectiveness of Reactant Pools for Generating Structurally-Diverse Combinatorial Libraries," Journal of Chemical Information Computer Sciences, vol. 37, No. 4, 1997, pp. 731-740.69Gobbi, A. et al., "New Leads By Selective Screening of Compounds From Large Databases," Abstracts for CINF sponsored symposia, Apr. 17, 1997, p. 22.70Good, A. C. et al., "Structure-Activity Relationships from Molecular Similarity Matrices", Journal of Medicinal Chemistry, vol. 36, No. 4, pp. 433-438, (Feb. 19, 1993).71Gordon, E. M., "Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions", Journal of Medicinal Chemistry, vol. 37, No. 10, (May 13, 1994).72Grayhill, T.L. et al., "Enhancing the Drug Discovery Process by Integration of High-Throughput Chemistry and Structure-Based Drug Design," from Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery, Chaiken and Janda (eds.), American Chemical Society, 1996, pp. 16-27.73Guez, Allon and Nevo, Igal, "Neural networks and fuzzy logic in clinical laboratory computing with application to integrated monitoring," Clinica Chimica Acta, 248, 1996, pp. 73-90.74Hall, L.H. and Kier, L.B., "The Molecular Connectivity Chi Indexes and Kappa Shape Indexes in Structure-Property Modeling," Reviews in Computational Chemistry: Advances, 1991, pp. 367-422.75Hartigan, J. A., "Representation of Similarity Matrices By Trees", Journal of the American Statistical Association, vol. 62, No. 320, pp. 1140-1158, (Dec., 1967).76Hecht-Nielsen, R., "Replicator Neural Networks for Universal Optimal Source Coding," Science, vol. 269, Sep. 29, 1995, pp. 1860-1863.77Hopfinger, A. J., "A QSAR Investigation of Dihydrofolate Reductase Inhibition by Baker Triazines based upon Molecular Shape Analysis", Journal of the American Chemical Society, vol. 102, No. 24, pp. 7196-7206, (Nov. 19, 1980).78Hotelling, H., "Analysis of a Complex of Statistical Variables into Principal Components," The Journal of Educational Psychology, vol. XXIV, No. 6, Sep. 1933, pp. 417-441.79Hotelling, H., "Analysis of a Complex of Statistical Variables into Principal Components," The Journal of Educational Psychology, vol. XXIV, No. 7, Oct. 1933, pp. 498-520.80Houghten, R.A. et al., "The Use of Synthetic Peptide Combinatorial Libraries for the Identification of Bioactive Peptides," Peptide Research, vol. 5, No. 6, 1992, pp. 351-358.81International Search Report for Appl. No. PCT/US99/09963, 7 pages.82Jackson, R. C., "Update on computer-aided drug design", Current Opinion in Biotechnology, vol. 6, No. 6, pp. 646-651, (Dec., 1995).83Kearsley, Simon K. et al., "Chemical Similarity Using Physiochemical Property Descriptors," Journal of Chemical Information Computer Science, 36, 1996, pp. 118-127.84Kim, K. H., "Comparative molecular field analysis (CoFMA)", Molecular Similarity in Drug Design, ed. P. M. Dean, Blackie Academic & Professional, 1995, Ch. 12 (pp. 291-324).85Klopman, G., "Artificial Intelligence Approach to Structure-Activity Studies. Computer Automated Structure Evaluation of Biological Activity of Organic Molecules," J. Am. Chem. Soc., vol. 106, No. 24, Nov. 28, 1984, pp. 7315-7321.86Kohonen. T., "Self-Organized Formation of Topologically Correct Feature Maps", Biological Cybernetics, vol. 43, pp. 59-69, (1982).87Koile, K. and Richard Shapiro, "Building A Collaborative Drug Design System", Proceedings of the 25h Hawaii International Conference on System Sciences, pp. 706-716, (1992).88Kowalski, B. R. and C. F. Bender, "Pattern Recognition. II. Linear and Nonlinear Methods for Dsiplaying Chemical Data", Journal of the American Chemical Society, pp. 686-693, (Feb. 7, 1973).89Kruskal, J.B., "Nonmetric Multidimensional Scaling: A Numerical Method", Psychometrika, vol. 29, No. 2, pp. 115-129, (Jun., 1964).90Lajiness, M.S. et al., "Implementing Drug Screening Programs Using Molecular Similarity Methods," QSAR: Quantitative Structure-Activity Relationships in Drug Design, 1989, pp. 173-176.91Lee, R.C.T. et al., "A Triangulation Method for the Sequential Mapping of Points from N-Space to Two-Space," IEEE Transactions on Computers, Mar. 1977, pp. 288-292.92Leland, Burton A. et al., "Managing the Combinatorial Explosion," Journal of Chemical Information Computer Science, 37, 1997, pp. 62-70.93Lengauer, T. and Matthias Rarey, "Computational methods for biomolecular docking", Current Opinion in Structural Biology, vol. 6, No. 3, pp. 402-406, (Jun., 1996).94Lewis, Richard A. et al., "Similarity Measures for Rational Set Selection and Analysis of Combinatorial Libraries: The Diverse Property-Derived (DPD) Approach," Journal of Chemical Information Computer Science, 37, 1997, pp. 599-614.95Lipinski, C.A. et al., "Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings," Advanced Drug Delivery Reviews, vol. 23, 1997, pp. 3-25.96Lobanov, V.S. and Agrafiotis, D.K., "Intelligent Database Mining Techniques," Abstracts of Papers Part 1: 215th ACS National Meeting, Mar. 29-Apr. 2, 1998, p. 19-COMP.97Lobanov, V.S. et al., "Rational Selections from Virtual Libraries," Abstracts of Papers Part 1: 217th ACS National Meeting, Mar. 21-25, 1999, p. 181-COMP.98Loew, G.H. et al., "Strategies for Indirect Computer-Aided Drug Design," Pharmaceutical Research, vol. 10, No. 4, 1993, pp. 475-486.99Luke, B. T., "Evolutionary Programming Applied to the Development of Quantitative Structure-Activity Relationships and Quantitative Structure-Property Relationships", Journal of Chemical Information and Computer Sciences, vol. 34, pp. 1279-1287, (Nov./Dec., 1994).100Lynch, M.F. et al., "Generic Structure Storage and Retrieval," J. Chem. Inf. Comput. Sci., vol. 25, No. 3, Aug. 1985, pp. 264-270.101Mao, J. and Jain, A.K., "Artificial Neural Networks for Feature Extraction and Multivariate Data Projection," IEEE transactions on Neural Networks, vol. 6, No. 2, Mar. 1995, pp. 296-317.102Martin, E. J. et al., "Does Combinatorial Chemistry Obviate Computer-Aided Drug Design?", Reviews, in Computational Chemistry, vol. 10, pp. 75-99, (1997).103Martin, E. J. et al., "Measuring Diversity: Experimetnal Design of Combinatorial Libraries for Drug Discovery", Journal of Medicinal Chemistry, vol. 38, No. 9, pp. 1431-1436, (Apr. 28, 1995).104Martin, Eric J. and Critchlow, Roger E., "Beyond Mere Diversity: Tailoring Combinatorial Libraries for Drug Discovery," Journal of Combinatorial Chemistry, vol. 1, No. 1, 1999, pp. 32-45.105McMartin, C. and Regine S. Bohacek, "QXP: Powerful, rapid computer algorithms for structure-based drug design", Journal of Computer-Aided Molecular Design, vol. 11, pp. 333-344, (1997).106Mezey, P. G. and P. Duane Walker, "Fuzzy molecular fragments in drug research", Drug Discovery Today, vol. 2, No. 4, (Apr., 1997).107M�ller, K., "On the paradigm shift from rational to random design", Journal of Molecular Structure (Theochem)398-399, Special Issue, pp. 467-471, (1997).108Myers, P., "The Design Of a Universal, Informer � Library", COMBICHEM, Inc., 10 Pages, Date unknown.109Myers, P.L. et al., "Rapid, Reliable Drug Discovery," Today's Chemist At Work, Jul./Aug. 1997, pp. 46-48, 51 & 53.110Oinuma, H. et al., "Neural Networks Applied to Structure-Activity Relationships" Journal of Medicinal Chemistry, vol. 33, No. 3, pp. 905-908, (1990).111Oja, E., "Principal Components, Minor Components, and Linear Neural Networks," Neural Networks, vol. 5, 1992, pp. 927-935.112Omohundro, S. M., "Bumptrees for Efficient Function, Constraint, and Classification Learning", International Computer Science Institute, pp. 693-699, Source and Date unknown.113Pabo et al., "Computer-Aided Model Building Strategies for Protein Design," Biochemistry, vol. 25, No. 20, 1986, pp. 5987-5991.114Parrill, A. L., "Evolutionary and genetic methods in drug design", Drug Discovery Today, vol. 1, No. 12, pp. 514-521, (Dec., 1996).115Patterson, D.E. et al., "Neighborhood Behavior: A Useful Concept for Validation of "Molecular Diversity' Descriptors," Journal of Medicinal Chemistry, vol. 39, No. 16, 1996, pp. 3049-3059.116Patterson, D.E. et al., "Neighborhood Behavior: A Useful Concept for Validation of �Molecular Diversity� Descriptors," Journal of Medicinal Chemistry, vol. 39, No. 16, 1996, pp. 3049-3059.117Polanski, J., "A neural network for the simulation of biological systems", Journal of Molecular Structure (Theochem)398-399, Special Issue, pp. 565-571, (1997).118Pykett, C.E., "Improving the Efficiency of Sammon's Nonlinear Mapping by Using Clustering Archetypes," Electronics Letters, vol. 14, No. 25, Dec. 7, 1978, pp. 799-800.119Ramos-Nino, M. E. et al., "A comparison of quantitative structure-activity relationships for the effect of benzoic and cinnamic acids on Listeria monocytogenes using multiple linear regression, artificial neural network and fuzzy systems", Journal of Applied Microbiology, vol. 82, No. 2, pp. 168-175, (Feb., 1997).120Rogers, D. and A. J. Hopfinger, "Application of Genetic Function Approximation to Quantitative Structure-Activity Relationships and Quantitative Structure-Property Relationships", Journal of Chemical Information and Computer Sciences, vol. 34, No. 4, pp. 854-866, (Jul./Aug., 1994).121Rubner, J. and Tavan, P., "A Self-Organizing Network for Principal-Component Analysis," Europhysics Letters, vol. 10, No. 7, Dec. 1, 1989, pp. 693-698.122Sadowski, J. et al., "Assessing Similarity and Diversity of Combinatorial Libraries by Spatial Autocorrelation Functions and Neural Networks," Angewandte Cheme, vol. 34, No. 23/24, Jan. 5, 1996, pp. 2674-2677.123Sammon, J. W., Jr., "A Nonlinear Mapping for Data Structure Analysis", IEEE Transactions on Computers, vol. C-18, No. 5, pp. 401-409, (May, 1969).124Saudek et al., "Solution Conformation of Endothelin-1 by H NMR, CD, and Molecular Modeling," International Journal of Peptide Protein Res., vol. 37, No. 3, 1991, pp. 174-179.125Saund, E., "Dimensionality-Reduction Using Connectionist Networks," IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 11, No. 3, Mar. 1989, pp. 304-314.126Sen, K. (ed.), Molecular Similarity I, Springer-Verlag, 1995, pp. 1-30.127Sheridan, Robert P. et al., "Chemical Similarity Using Geometric Atom Pair Descriptors," Journal of Chemical Information Computer Science, 36, 1996, pp. 128-136.128Simon, Z. et al., "Mapping of dihydrofolate-reductase Receptor Site by Correlation with Minimal Topological (Steric) Differences", Journal of Theoretical Biology, vol. 66, No. 3, pp. 485-495, (Jun. 7, 1997).129Singh, J. et al., "Application of Genetic Algorithms to Combinatorial Synthesis: A Computational Approach to Lead Identification and Lead Optimization," J. Am. Chem. Soc., vol. 118, No. 7, Feb. 21, 1996, pp. 1669-1676.130Smellie, A. S. et al., "Fast Drug-Receptor Mapping by Site-Directed Distances: A Novel Method of Predicting New Pharmacological Leads", Journal of Chemical Information and Computer Sciences, vol. 31, No. 3, pp. 386-392, (Aug., 1991)131Specht, D. F., "A General Regression Neural Network", IEEE Transactions on Neural Networks, vol. 2, No. 6, pp. 568-576, (Nov., 1991).132Svozil, D. et al., "Neural Network Prediction of the Solvatochromic Polarity/Polarizability Parameter IIH2", Journal of Chemical Information and Computer Sciences, vol. 37, No. 2, (1997).133Thompson, L.A. and Ellman, J.A., "Synthesis and Applications of Small Molecule Libraries," Chemical Reviews, vol. 96, No. 1, Jan./Feb. 1996, pp. 555-600.134Todorov, N. P. and P. M. Dean, "Evaluation of method for controlling molecular scaffold diversity in de novo ligand design", Journal of Computer-Aided Molecular Design, vol. 11, pp. 175-192, (1997).135Torgerson, W. S., "Multidimensional Scaling: I. Theory and Method", Psychometrika, vol. 17, No. 4, pp. 401-419, (Dec., 1952).136Van Drie, J.H. and Lajiness, M.S., "Approaches to virtual library design," Drug Discovery today, vol. 3, No. 6, Jun. 1998, pp. 274-283.137Vapnik, V. and L. Bottou, "Local Algorithms for Pattern Recognition and Dependencies Estimation",Neural Computation, vol. 5, No. 6, pp. 893-909, (Nov., 1993).138Vapnik, V., "Principles of Risk Minimization for Learning Theory", Advances in Neural Information Processing Systems 4, pp. 831-838, Date unknown.139Viswanadhan, V. N. et al., "Mapping the binding site of the nucleoside transporter protein: a 3D-QSAR study", Biochimica et Biophysica Acta, vol. 1039, No. 3, pp. 356-366, (1990).140Walters, W.P. et al., "Virtual screening-an overview," Drug Discovery today, vol. 3, No. 4, Apr. 1998, pp. 160-178.141Walters, W.P. et al., "Virtual screening�an overview," Drug Discovery today, vol. 3, No. 4, Apr. 1998, pp. 160-178.142Warr, W. A., "Exploiting Molecular Diversity: Small Molecule Libraries for Drug Discovery", Report of Conference held in La Jolla, California, Jan. 23-25, 1995.143Weber, L. et al., "Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm," Angewandte Chemie International Edition in English, vol. 34, No. 20, 1995, pp. 2280-2282.144Weber, L., "Evolutionary combinatorial chemistry: application of genetic algorithms," Drug Discovery today, vol. 3, No. 8, Aug. 1998, pp. 379-385.145Westhead, D. R. et al., "A comparison of heuristic search algorithms for molecular docking", Journal of Computer-Aided Design, vol. 11, pp. 209-228, (1997).146Willett, P. and Vivienne Winterman, "A Comparison of Some Measures for the Determination of Inter-Molecular Structural Similarity Measures of Inter-Molecular Structural Similarity",Quantitative Structure-Activity Relationships, vol. 5, No. 1, pp. 18-25, (Mar., 1986).147Willett, P., "Genetic algorithms in molecular recognition and design" Trends in Biotechnology, vol., 13, No. 12, pp. 516-521, (Dec., 1995).148Willett, Peter et al., "Chemical Similarity Searching," Journal of Chemical Information Computer Science, 38, 1998, pp. 983-996.149Zadeh, L. A., "Communication Fuzzy Algorithms", Information and Control, vol. 12, No. 2, pp. 94-102, (Feb., 1968).150Zadeh, L. A., "Fuzzy Sets", Information and Control, vol. 8, No. 3, pp. 338-353, (Jun., 1965).Referenced byCiting PatentFiling datePublication dateApplicantTitleUS6584413 *Jun 1, 2001Jun 24, 2003Sandia CorporationApparatus and system for multivariate spectral analysisUS6587845 *Feb 15, 2000Jul 1, 2003Benjamin B. BraunheimMethod and apparatus for identification and optimization of bioactive compounds using a neural networkUS6594673 *Sep 9, 1999Jul 15, 2003Microsoft CorporationVisualizations for collaborative informationUS6615211 *Mar 19, 2001Sep 2, 2003International Business Machines CorporationSystem and methods for using continuous optimization for ordering categorical data setsUS6647341 *Apr 6, 2000Nov 11, 2003Whitehead Institute For Biomedical ResearchBased on gene expression; sorting genes by degree to which their expression in the samples correlate with a class distinctionUS6665685 *Nov 1, 1999Dec 16, 2003Cambridge Soft CorporationDeriving database interaction softwareUS6757618 *May 9, 2001Jun 29, 2004Pharmacia & Upjohn CompanyChemical structure identificationUS6925389Jul 18, 2001Aug 2, 2005Correlogic Systems, Inc.,Process for discriminating between biological states based on hidden patterns from biological dataUS6968342 *Jun 19, 2001Nov 22, 2005Abel WolmanEnergy minimization for data merging and fusionUS7046247 *May 15, 2002May 16, 2006Hewlett-Packard Development Company, L.P.Method for visualizing graphical data sets having a non-uniform graphical density for displayUS7054757Jan 29, 2002May 30, 2006Johnson & Johnson Pharmaceutical Research & Development, L.L.C.for generating mapping coordinates of combinatorial library products from features of library building blocks; pattern analysis, information representation, information cartography and data miningUS7096206Jun 19, 2001Aug 22, 2006Correlogic Systems, Inc.Heuristic method of classificationUS7106903 *Sep 24, 2002Sep 12, 2006Vima Technologies, Inc.Dynamic partial function in measurement of similarity of objectsUS7117187May 2, 2003Oct 3, 2006Johnson & Johnson Pharmaceutical Reseach & Develpment, L.L.C.Method, system and computer program product for non-linear mapping of multi-dimensional dataUS7139739Apr 3, 2001Nov 21, 2006Johnson & Johnson Pharmaceutical Research & Development, L.L.C.Method, system, and computer program product for representing object relationships in a multidimensional spaceUS7167851 *Jan 31, 2001Jan 23, 2007Accelrys Software Inc.One dimensional molecular representationsUS7188055 *Mar 12, 2001Mar 6, 2007Johnson & Johnson Pharmaceutical Research, & Development, L.L.C.Method, system, and computer program for displaying chemical dataUS7199809 *Oct 18, 1999Apr 3, 2007Symyx Technologies, Inc.Graphic design of combinatorial material librariesUS7225172 *Nov 26, 2002May 29, 2007Yeda Research And Development Co. Ltd.Method and apparatus for multivariable analysis of biological measurementsUS7240038Nov 15, 2005Jul 3, 2007Correlogic Systems, Inc.Heuristic method of classificationUS7246329 *Jul 17, 2001Jul 17, 2007Autodesk, Inc.Multiple menus for use with a graphical user interfaceUS7272509May 5, 2000Sep 18, 2007Cambridgesoft CorporationManaging product informationUS7295931Feb 18, 2000Nov 13, 2007Cambridgesoft CorporationDeriving fixed bond informationUS7324926Oct 1, 2001Jan 29, 2008Whitehead Institute For Biomedical ResearchMethods for predicting chemosensitivity or chemoresistanceUS7333895Jul 28, 2003Feb 19, 2008Correlogic Systems, Inc.Quality assurance for high-throughput bioassay methodsUS7333896Jul 28, 2003Feb 19, 2008Correlogic Systems, Inc.Quality assurance/quality control for high throughput bioassay processUS7356419May 5, 2000Apr 8, 2008Cambridgesoft CorporationDeriving product informationUS7395160Jul 28, 2003Jul 1, 2008Correlogic Systems, Inc.Quality assurance/quality control for electrospray ionization processesUS7401056 *May 29, 2007Jul 15, 2008Yeda Research And Development Co. Ltd.Method and apparatus for multivariable analysis of biological measurementsUS7499891Apr 13, 2007Mar 3, 2009Correlogic Systems, Inc.Heuristic method of classificationUS7761239Dec 10, 2004Jul 20, 2010Correlogic Systems, Inc.Method of diagnosing biological states through the use of a centralized, adaptive model, and remote sample processingUS7805255Nov 13, 2007Sep 28, 2010Cambridgesoft CorporationDeriving fixed bond informationUS7805437 *May 15, 2003Sep 28, 2010Spotfire AbInteractive SAR tableUS7912689Feb 11, 2000Mar 22, 2011Cambridgesoft CorporationEnhancing structure diagram generation through use of symmetryUS8032469 *May 6, 2008Oct 4, 2011Microsoft CorporationRecommending similar content identified with a neural networkUS8136045 *Jul 3, 2007Mar 13, 2012Autodesk, Inc.Multiple menus for use with a graphical user interfaceUS8230364 *Jun 30, 2004Jul 24, 2012Sony United Kingdom LimitedInformation retrievalUS8373660 *Jul 14, 2004Feb 12, 2013Matt PallakoffSystem and method for a portable multimedia clientUS8530838Dec 21, 2010Sep 10, 2013Saint-Gobain Ceramics & Plastics, Inc.Radiation detection system and method of indicating presence of radiationUS8594435 *Jan 3, 2011Nov 26, 2013Sony CorporationImage processing device and method, and program thereforUS8664358Jun 30, 2008Mar 4, 2014Vermillion, Inc.Predictive markers for ovarian cancerUS20050004910 *Jun 30, 2004Jan 6, 2005Trepess David WilliamInformation retrievalUS20110113385 *Nov 6, 2009May 12, 2011Craig Peter SayersVisually representing a hierarchy of category nodesUS20110188758 *Jan 3, 2011Aug 4, 2011Sony CorporationImage processing device and method, and program thereforUS20120271835 *Oct 18, 2010Oct 25, 2012Nicolas GaudeUser request based content rankingWO2002061419A1 *Jan 29, 2002Aug 8, 2002Dimensional Pharm IncMethod, system, and computer program product for analyzing combinatorial librariesWO2006114479A1 *Apr 26, 2006Nov 2, 2006Erno LindforsVisualization technique for biological information* Cited by examinerClassifications U.S. Classification703/12, 702/30, 702/181, 702/32, 702/27, 702/179, 702/31, 703/2, 702/180, 702/28International ClassificationG06F17/30, G06T11/20, C07B61/00, G06F17/50, G01N33/15, G06N3/00, G06F19/00, G06T17/40, G06F19/26, B01J19/00, G06F15/18, G01N33/00, G06F19/16Cooperative ClassificationB01J2219/007, B01J2219/00695, C40B40/00, G06K9/6253, G06K9/6251, B01J2219/00702, B01J19/0046, G06F19/708, B01J2219/00691, G06T11/206, G06F19/707, B01J2219/00689European ClassificationG06F19/70, B01J19/00C, G06T11/20T, G06K9/62B5, G06K9/62B4TLegal EventsDateCodeEventDescriptionFeb 27, 2013FPAYFee paymentYear of fee payment: 12Feb 25, 2009FPAYFee paymentYear of fee payment: 8Feb 28, 2005FPAYFee paymentYear of fee payment: 4Aug 4, 1998ASAssignmentOwner name: 3-DIMENSIONAL PHARMACEUTICALS, INC., PENNSYLVANIAFree format text: CORRECTION TO CORRECT THE EXECUTION DATE, PREVIOUSLY RECORDED AT REEL 9182 FRAME 0404.;ASSIGNORS:AGRAFIOTIS, DIMITRIS K.;LOBANOV, VICTOR S.;SALEMME, FRANCIS R.;REEL/FRAME:009343/0202;SIGNING DATES FROM 19980408 TO 19980409May 19, 1998ASAssignmentOwner name: 3-DIMENSIONAL PHARMACEUTICALS, INC., PENNSYLVANIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:AGRAFIOTIS, DIMITRIS K.;LOBANOV, VICTOR S.;SALEMME, FRANCIS R.;REEL/FRAME:009182/0404Effective date: 19980408RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google