Source: https://patents.google.com/patent/ES2658360T3/en
Timestamp: 2020-05-28 23:18:13
Document Index: 419268642

Matched Legal Cases: ['art 610', 'art 608', 'art 610', 'art 610', 'art 608', 'art 808', 'art 808', 'art 908', 'art 908']

ES2658360T3 - System for the ablation of a lens - Google Patents
System for the ablation of a lens Download PDF
ES2658360T3
ES2658360T3 ES12838722.2T ES12838722T ES2658360T3 ES 2658360 T3 ES2658360 T3 ES 2658360T3 ES 12838722 T ES12838722 T ES 12838722T ES 2658360 T3 ES2658360 T3 ES 2658360T3
ES12838722.2T
Jr. William E. Brown
2011-10-03 Priority to US201161542702P priority Critical
2011-10-03 Priority to US201161542702P priority
2011-10-26 Priority to US201161551826P priority
2012-10-02 Application filed by Biolase Inc filed Critical Biolase Inc
2012-10-02 Priority to PCT/US2012/058455 priority patent/WO2013052481A1/en
2018-03-09 Publication of ES2658360T3 publication Critical patent/ES2658360T3/en
238000002679 ablation Methods 0 title claims abstract description 39
238000003973 irrigation Methods 0 claims abstract description 13
230000002262 irrigation Effects 0 claims abstract description 13
210000000795 Conjunctiva Anatomy 0 claims description 22
A system for removing a lens from one eye, comprising: a visible light pattern projector (602; 802; 902) configured to project an ablation pattern (608, 610; 808, 810; 909, 910) on the lens (606; 704; 804; 1010; 1106) of the eye; a laser tool (414; 1102) configured to be inserted through an access incision in the eye, in which the laser tool includes: an irrigation port (1008; 1110) configured to introduce water (1104) into the lens ( 606; 704; 804; 1010; 1106) through a sprayer; a flexible tip (1004; 1304) configured to focus electromagnetic energy according to the visible light pattern (608, 610; 808, 810; 909, 910) such that electromagnetic energy reacts with water (1104) to remove the lens (606; 704; 804; 1010; 1106) as a plurality of pieces; and a suction port (1012; 1114) configured to suction the plurality of pieces of the lens after ablation of the lens (606; 704; 804; 1010; 1106).
System for the ablation of a crystalline field
The technology described in this document generally refers to ocular treatment and, more particularly, to ablation of ocular tissue.
A cataract is a cloudiness that develops in the lens of the lens of the eye or in its envelope (capsule of the lens), which varies in degree of opacity from mild to complete and that obstructs the passage of light. Cataracts can be partial or complete, stationary or progressive, or hard or soft. Generally, as cataracts progress, the hardness or toughness of the cataract increases. Cataracts are sometimes treated by cutting the affected lens with a scalpel and removing it from the eye before replacing the lens. Such treatment may require large incisions in the eye and may put at risk sensitive, non-crystalline tissue, especially as the cataract hardens and becomes more difficult to cut.
US Patent 6,623,477 B1 discloses a system for removing a lens from an eye that comprises means for focusing laser energy using an inserted laser tool to remove a portion of the lens, in which said ablation breaks the lens, with the lens being provided. fluid irrigation system and aspiration means to facilitate the removal of the broken lens.
Examples of systems and methods for removing a lens from one eye are provided. An access incision is made through external eye tissue to access the lens. A laser tool is inserted through the access incision. Electromagnetic energy is focused using the inserted laser tool to remove a portion of the lens, where said ablation breaks the lens into a plurality of pieces for removal from the eye.
In another example, a system for removing a lens from one eye includes a visible light pattern projector configured to project an ablation pattern onto the lens of the eye. A laser tool is configured to be inserted through an access incision in the eye. The laser tool includes an irrigation port configured to introduce water into the lens through a sprayer, a flexible tip that is configured to focus electromagnetic energy according to the visible light pattern, where electromagnetic energy reacts with water to remove the lens as a plurality of pieces, and a suction port configured to suction out the plurality of pieces of the lens after ablation of the lens.
Figure 1 is a diagram representing the ablation of a lens of an eye.
Figure 2 is a side view of an eye representing access to inner tissue of the eye through an access incision.
Figure 3 represents a top view of an access incision made from the front or above the lens.
Figure 4 is a diagram depicting access to the lens through an incision through external eye tissue outside the radius of the lens.
Figure 5 represents a benefit of an incision from outside the lens radius that can be achieved by rotating the conjunctiva.
Figure 6 is a diagram depicting a visible light pattern projector that projects an ablation pattern on the lens of an eye.
Figure 7 is a diagram depicting an example of ablation of portions of a projected pattern using a flexible laser tip laser tool.
Figure 8 is a diagram depicting a visible light pattern projector projecting a pattern of thin sheets on an eye lens.
Fig. 9 is a diagram depicting a visible light pattern projector projecting a concentric circle pattern on an eye lens.
Figure 10 is a diagram depicting an example laser tool.
Figure 11 is a diagram representing a potential benefit of water from the irrigation port.
Figure 12 is a diagram depicting the removal of certain pieces of an excised lens.
Figure 13 depicts an example laser tool that includes a flexible tip.
Figure 14 is a diagram depicting an eye with a removed lens that has germination cells present.
Figure 15 is a diagram depicting the insertion of a replacement lens using a folded lens technique.
Figure 16 is a diagram depicting an eye that has a replacement lens placed after removal of a previous lens.
Figure 17 represents examples of laser tips.
Figure 1 is a diagram representing the ablation of a lens of an eye. An eye 102 is depicted, where the eye 102 includes a lens 104 placed within the eye 102. At least a portion of the lens 104 is visible from the outside of the eye through a pupil 106. A portion of the lens 104 may be hidden from sight by an iris 108. During an ocular intervention, the pupil may dilate to provide better access to, and vision of, the lens 104.
In certain interventions, it is desirable to remove, destroy or separate certain tissues within the eye 102. For example, in a cataract treatment intervention, it may be desirable to remove a lens affected by cataracts and replace the removed lens 104 with a replacement lens ( for example, a synthetic replacement lens). Removal of the lens 104 may be desirable for the treatment of other conditions, such as presbyopia, in which the lens 104 is unable to change its curvature for near vision.
Large incisions in the eye can affect vision as well as being painful, slow healing and susceptible to infection. Therefore, when an eye treatment is performed that requires the removal of the lens 104, the making of an incision that spans the entire width of the lens 104 may not be optimal. Figure 1 depicts a method of ablating a lens of an eye for removal that can be performed through a smaller access incision. An access incision 110, identified by an "x" in Figure 1, is made through external ocular tissue to access the lens 104. A laser tool 112, or a part thereof, is inserted through the incision 110. The electromagnetic energy is focused using the inserted laser tool 112 to remove a portion of the lens 104, where that ablation breaks the lens into a plurality of pieces for removal from the eye 102. In the example of Figure 1, The electromagnetic energy is focused along the dotted lines to break the lens into a plurality of pie-shaped pieces 114. These pie-shaped pieces 114 are smaller than the entire crystalline 104 and can be extracted through the access incision 110. The plurality of pieces 114 can be removed in various ways, such as by tweezers or suction.
Figure 2 is a side view of an eye representing access to inner tissue of the eye through an access incision. An access incision 202 is made through certain layers of external ocular tissue, such as the conjunctiva 204 and the sclera 206. The access incision 202 can also pass through certain internal structure of the eye, such as trabecular mesh 208, when searching access to the internal structure, such as the lens 210. In a lens removal intervention, the lens 210, or the tissue surrounding the lens 210, is accessed through the access incision 202 for removal. Electromagnetic energy is focused through the access incision 202 on the lens 210, or tissue surrounding the lens 210, to separate the lens 210 from the eye and break the lens for extraction through the access incision 202. In a For example, a laser tool (e.g., a flexible laser tip) is inserted through the access incision 202 and maneuvered to focus the electromagnetic energy on the lens 210 in order to remove the lens 210 as a plurality of pieces for its extraction according to a predetermined pattern.
Although Figure 2 depicts access to the lens through an access incision 202 made from outside the radius of the lens 210, the lens 210 and other internal structures can be accessed through other types of access incisions, such as a access incision made from the front or above the lens, as indicated in 212, as well as other types of incisions. Figure 3 shows a top view of an access incision of this type from the front or above the lens. In Fig. 3, a lens 302 is represented in the center of an eye 304, where lens 302 is visible through a pupil 306 in the center of an iris 308. During an intervention, the pupil 306 may be dilated, and the access incision 310 can be made in front of or above the lens 302 to access the lens 302 through the pupil 306.
Figure 4 is a diagram showing access to the lens through an incision through external eye tissue outside the radius of the lens. In Figure 4, a lens 402 is depicted in the center of an eye 404. The lens 402 is visible through the pupil of the eye 406 that is surrounded by the iris 408. The iris 408 is surrounded by
certain outer layers of eye tissue, such as the sclera and conjunctiva, the white portion of the eye. In the example of Figure 4, the lens is accessed through an access incision 412 (for example, a 3 mm incision) made through the external eye tissue 410 near, but outside, the radius of the lens 402 (by example, through the corneoesclerotic edge). The incision 412 can be made using a cutting tool, such as a scalpel or a laser. The same cutting tool 414 or another cutting tool of the same or different type is inserted through the access incision 412 to access the internal eye tissue, such as lens 402. For example, a laser tool can be used, such as a flexible or inflexible tip, to make the access incision 412, wherein the laser tool is inserted through the access incision 412 to focus the electromagnetic energy on the lens 402 in order to remove the lens as a plurality of parts in order to facilitate the extraction of the lens of the eye 404. The laser tool (for example, a mid-infrared laser with a wavelength between 2,750 and 3,000 nm) can be operated in different configurations depending on the type of tissue being cut or removing (for example, energy levels from 0.05 to 3 watts at 5-100 Hz). For example, a setting of 1.25 watts at 20 Hz and a short pulse duration can be used to cut through the conjunctiva, while a setting of 0.25 watts at 30 Hz can be used for lens ablation , using higher settings for harder cataracts (for example 0.75 watts).
Ablations can be done using several mechanisms. For example, ablations can be done using a manual laser tool maneuvered by a surgeon or other technician who performs an ablation treatment. In another example, ablations can be done using a computer-controlled scanner that is configured to perform ablations at one or more points at the same time within the process of making an ablation pattern according to a predefined or preprogrammed pattern. Such ablation interventions may allow the lens to be divided into a plurality of pieces for removal without the use of ultrasonic interventions or other shaking interventions, which can damage the eye tissue.
Making the access incision outside the radius can have several advantages. For example, an access incision made outside the lens radius can prevent unintentional damage to certain sensitive eye structures when treatments are performed. For example, when a lens is accessed from the front or above the lens through the pupil, the integrity of the pupil is compromised by the potential damage to the iris. By accessing the lens from the side, such risks can be mitigated.
Figure 5 represents another potential benefit of an incision from outside the lens radius that can be achieved by rotating the conjunctiva. The conjunctiva and the sclera 502 are outer layers of ocular tissue that form the white part of an eye, where the conjunctiva sits at the top of the sclera and can slide or rotate with respect to the sclera. In the example of Fig. 5, the conjunctiva layer is rotated from a resting position 504 to a rotated position 506 with respect to the sclera and other underlying eye tissue, such as crystalline 508. The conjunctiva can be held in the rotated position. 506 using a finger or a clamp. The access incision in 506 is made near the outside of the lens in 506 with the conjunctiva in the rotated position 506. The access incision crosses the conjunctiva and the sclera to access the internal ocular tissue, such as the lens 508. The conjunctiva is it remains in the rotated position 506 and the treatments are applied to the internal ocular tissue through the access incision that breaks the conjunctiva in the rotated position indicated in 506 and other ocular tissue below that point.
When the treatment is completed and the access incision treatment tools are removed, the conjunctiva is allowed to return to its resting position 504. As the conjunctiva relaxes to its resting position 504, the part of the access incision crosses the conjunctiva moves to the restful position 504, while the part of the access incision that crosses the lower layers of eye tissue, such as the sclera, remains close to the lens 508. In this way, the damaged portions of the conjunctiva and sclera, and other internal eye tissues are staggered. This staggering provides an undamaged portion of conjunctiva to cover the damaged sclera and lower level tissue, which can help prevent infection. In addition, the staggering of damaged layers of eye tissue improves blood flow to the damaged layers individually, improving healing times.
In certain implementations, it may be desirable to remove the target eye tissue according to a predetermined or predefined pattern. For example, during an intervention to remove a lens from one eye, the lens can be removed as a plurality of pieces according to a pattern for removal through an incision that is smaller than the full diameter of the lens. Figure 6 is a diagram depicting a visible light pattern projector that projects an ablation pattern on the lens of an eye. A visible light pattern projector 602 projects a visible light pattern onto a portion of an eye 604. In the example of Figure 6, the visible light pattern projector 602 transmits a pattern on the lens 606 of the eye 604, identifying a pattern to follow to cut the lens 606 using a scalpel, laser or other cutting tool to extract the lens 606 from the eye 604. The pattern in Figure 6 is a pie-shaped pattern consisting of a first substantially circular portion 608 and a second part 610 consisting of a plurality of cross sections within the first substantially circular portion 608. The visible light pattern can be projected using a variety of mechanisms, such as a low power laser or visible light projected through a mask. The visible light pattern can be projected in a variety of ways, even in three dimensions (3D). For example, a 3D pattern can be used to help guide the depth of certain ablations or cuts.
Access to the lens 606 is achieved through an access incision that can be made from the front or above the lens 606, as indicated in 612, or from outside the radius of the lens 606, as indicated in 614. After accessing to lens 606, lens 606 is divided into a plurality of pieces by making cuts or ablations along, or through, the lines of pattern 608, 610 projected onto lens 606 by the visible light pattern projector 602. For example , electromagnetic energy can be focused through a flexible laser tip inserted in the access incision 614 to remove the lens 606 along the first substantially circular part 608 of the projected pattern and then along the internal cross sections of the second part 610 of the visible light pattern 608, 610. In another example, the internal cross sections of the second part 610 can be made before the substance cuts are made Circularly of the first part 608 of the pattern. The individual pieces of the lens 606 that remain after the laser ablation can then be removed from the eye 604 through the access incision 614, which allows the minimization of the size of the access incision 614 necessary for the removal of the lens 606 .
Figure 7 is a diagram showing an example ablation of portions of a projected pattern using a flexible laser tip laser tool. In Figure 7a, the flexible tip is inserted through an access incision near the 9:00 position of the lens. In Fig. 7b, electromagnetic energy is focused along the periphery of the lens from position 9:00 to position 6:00, removing the outer edge of the lens, such as according to a substantially circular portion of a projected ablation pattern on the lens. In some implementations, electromagnetic energy can be focused all the way to the 3:00 position by maneuvering the flexible laser tip. In Figure 7c, the flexible tip retracts to the 9:00 position and, in Figure 7d, electromagnetic energy is focused in the other direction along the edge of the lens through the 12:00 position and continues until 3:00 position to complete the ablation of the outer edge of the lens. In Figure 7e, the flexible laser tip retracts to the 9:00 position and is removed through the access incision.
The patterns projected by a visible light pattern projector can take a variety of forms. Figure 8 is a diagram depicting a visible light pattern projector projecting a pattern of thin sheets on an eye lens. The visible light pattern projector 802 projects a visible light pattern onto a lens 804 of an eye 806, such as to guide the cutting or ablation of the eye lens tissue 804. The pattern projected in Figure 8 consists of a first substantially circular part 808 and a plurality of parallel transverse cuts 810. In practice, a cutting tool can be inserted through an access incision, such as one of the incisions depicted in 812, 814. The cutting tool can be used for cutting or removing the lens 804 along the plurality of parallel cross-cutting lines 810 that are projected onto the lens 804 by the visible light pattern projector 802. The cutting tool can then be used to cut or remove the lens 804 along the substantially circular part 808 of the projected pattern. It is noted that the order of the cuts can be changed along, or through, the projected pattern. The plurality of strips resulting from the lens can then be extracted through the access incision used 812, 814.
Fig. 9 is a diagram depicting a visible light pattern projector projecting a concentric circle pattern on an eye lens. The visible light pattern projector 902 projects a visible light pattern on a lens 904 of an eye 906, such as to guide the cutting or ablation of the eye lens tissue 904. The pattern projected in Figure 9 consists of a substantially circular first part 908 and a plurality of concentric circular internal cuts 910. In practice, a cutting tool can be inserted through an access incision, such as one of the incisions shown in 912, 914. The cutting tool can be used to cut, remove or break the lens 904 along the plurality of concentric circular lines 910 that are projected onto the lens 904 by the visible light pattern projector 902, or using a computer scanner with an optical system such as LensX. The cutting tool can then be used to cut or remove the lens 904 along the substantially circular part 908 of the projected pattern. The plurality of strips resulting from the lens can then be extracted through the access incision used 912, 914 (for example, an arcuit excimer incision), such as by folding the circular portions of the lens before extraction, where it is not possible such folding of an uncut solid lens.
Figure 10 is a diagram depicting an example laser tool. Electromagnetic energy, such as laser energy, is provided to the laser tool at a first end 1002. The electromagnetic energy is propagated along the length of the laser tool, through a laser tip 1004, where the electromagnetic energy is it radiates from at least the end 1006 of the laser tip 1004. The laser tool shown in Figure 10 may further include an irrigation port 1008 that is configured to introduce water into a treatment site, such as a lens 1010 of an eye, spraying water from the irrigation port 1008 to the treatment site near the end 1006 of the laser tip 1004. The water provided by the irrigation port 1008 can serve a variety of purposes. For example, the irrigation port may provide water to a crystalline treatment site 1010 to release fragments of the lens 1010 in order to facilitate suction extraction of the fragments from a suction port 1012.
Figure 11 is a diagram representing an additional potential benefit of the water coming from the irrigation port. In the example of Figure 11, the electromagnetic energy is provided by an Er: YSGG laser of 2.78 nm. The effectiveness of such laser 1102 in performing ablation and cutting treatments is enhanced when that laser 1102 interacts with water 1104 present at the treatment site, such as treatment site 1106.
crystalline. In fact, such laser 1102 cannot perform any cutting or ablation when its electromagnetic energy 1108 is focused outside the presence of water 1104. However, when such laser 1102 is focused on a treatment site 1106 where water 1104 is present, such as water 1104 sprayed from the irrigation port 1110, tissue is cut or removed at the treatment site, such as lens 1106, (for example, by microexpansion and microablation of water), as indicated in 1112. A laser of this type is described in U.S. Patent No. 8,033,825. After ablation using water from the irrigation port 1110, the plurality of pieces of the lens 1106 can be extracted through the suction port 1114 with or without additional water 1104 from the irrigation port 1110 as an aid.
After ablation of portions of the lens to divide the lens into a plurality of pieces, the pieces of the lens are removed from the eye, such as through the suction port shown in Figures 10 and 11, using surgical tweezers, or another way. Figure 12 is a diagram depicting the removal of certain pieces of an excised lens. The depicted eye 1202 includes a lens 1204, which has been removed according to a cake-shaped pattern 1206. The dotted lines represent the lens tissue that has been removed and is no longer present as part of the lens pieces. After the ablation, the crystalline 1204 is divided into six pie-shaped pieces. Each of these pieces is smaller than the lens 1204 as a whole and, therefore, can be removed by a smaller incision, such as the incision depicted in 1208. Each of the pieces is removed separately. In the example of Figure 12, two of the pieces 1210 have been removed, while four of the pie-shaped pieces 1212 have not yet been removed through the access incision 1206.
As indicated above, ablation of the lens and other eye tissue can be performed using a variety of different laser tips of different types and sizes. Figure 13 depicts an example laser tool that includes a flexible tip. The laser tool can use a LensSx® laser from Alcon Laboratories, Inc., an excimer laser or other type laser. A flexible tip 1304 allows the ablation of portions of a lens or other tissue in one eye. The flexible tip 1304 can take a variety of forms, such as an extreme, flat, sharp or curved trigger tip or a lateral trigger tip or radial trigger tip. The laser tip 1304 can take a variety of forms. For example, the laser tip 1304 may be a lateral firing laser tip, such as that described in United States Patent No. 8,221,117 or United States Patent No. 7,702,196. Certain examples of laser tips are depicted in Figure 17. Examples of laser tips 1304 may further include the Perio 300 tip of BioLase, Inc., part number 740020. This tip has the convenience of Twist-on and eliminates the time consumption of detachment and excision. This tip is flexible to access all areas of the eye and can be used as a single use tip. The Perio 300 tip has a diameter of 1.1 mm and a fiber length of 7 mm or 9 mm with an outer tubular length of 15 mm.
After removal of all or most of the lens of an eye, certain undesirable remnants of the lens or other unwanted tissue may remain in the eye. For example, during a cataract removal intervention, germination cells may remain in the eye after lens ablation. Over time, these germination cells can be a starting point for the generation of a new cataract in a replacement lens, which limits the benefit of cataract intervention. Therefore, it may be desirable to locate and remove any germination cell after lens extraction and before the end of an intervention. Germination cells can be seen using a microscope or the naked eye after removing the lens. Figure 14 is a diagram depicting an eye with a removed lens that has germination cells present. Figure 14 depicts an eye 1402 having a lens 1404 that has been removed, such as using one of the interventions described above. After removal of lens 1404, germination cells 1406 reside at or near the site of the removed lens. To prevent the regrowth of cataracts, these germination cells 1406 are located, and electromagnetic energy is focused on germination cells 1406 to remove germination cells 1406.
After removal of the lens from an eye, a replacement intraocular lens can be placed inside the capsular bag that previously occupied the natural lens. Figure 15 is a diagram depicting the insertion of a replacement lens using a folded lens technique. A crystalline lens is displayed in an unfolded form in 1502. That unfolded lens 1502 can be folded one or more times as indicated, to reduce the width of the folded lens 1504 to a width that can be adjusted through an access incision 1506. During an intervention, the folded lens 1504 is inserted into the membrane cavity that previously occupied the natural lens. Once inside the eye, the lens unfolds and is placed correctly. Figure 16 is a diagram depicting an eye having a replacement lens positioned after removal of an anterior lens. Eye 1602 includes a replacement lens 1604, indicated by the thick line, which has been placed in the place of a natural lens or previously positioned. After the end of the intervention, if the conjunctiva was rotated before making the access incision, that rotation can be released, moving the conjunctiva incision away from the intervention site, as indicated in 1606, which provides a potential improvement. of the healing of both the conjunctiva and the underlying intervention site.
1. A system for removing a lens from one eye, which comprises:
a visible light pattern projector (602; 802; 902) configured to project an ablation pattern (608, 610; 808, 810; 909, 910) on the lens (606; 704; 804; 1010; 1106) of the eye ;
a laser tool (414; 1102) configured to be inserted through an access incision in the eye, in which the laser tool includes:
an irrigation port (1008; 1110) configured to introduce water (1104) into the lens (606; 704; 804; 1010; 1106) through a sprayer;
a flexible tip (1004; 1304) configured to focus electromagnetic energy according to the visible light pattern (608, 610; 808, 810; 909, 910) such that electromagnetic energy reacts with water (1104) to remove the lens (606; 704; 804; 1010; 1106) as a plurality of pieces; Y
a suction port (1012; 1114) configured to suction the plurality of pieces of the lens after ablation of the lens (606; 704; 804; 1010; 1106).
means (414) for making the access incision through external eye tissue access to the lens (606; 704; 804; 1010; 1106).
3. The system according to claim 1 or 2, wherein a first part (608; 808; 908) of the ablation pattern has a substantially circular shape, and in which the first part is projected onto or near an outer edge of the lens (606; 704; 804; 1010; 1106).
4. The system according to claim 3, wherein the electromagnetic energy is focused through the first part (608; 808; 908) of the ablation pattern to separate the lens (606; 704; 804; 1010; 1106) from the eye tissue surrounding the lens, preferably in which a second part (610; 810; 910) of the ablation pattern is within the first substantially circular part, and in which the electromagnetic energy is focused through the second part of the ablation pattern to remove the lens as a plurality of pieces.
5. The system according to any one of claims 1 to 4, wherein the plurality of pieces is removable through the access incision.
6. The system according to any one of claims 1 to 5, wherein the lens is too large to be removed through the access incision before the ablation in the form of the plurality of pieces, or in which the incision of access is an incision made through external ocular tissue in front of or above the lens, or in which the access incision is an incision made through a conjunctiva of the eye outside a radius of the lens.
7. The system according to any one of claims 1 to 6, wherein the flexible laser tip (1004; 1304) is a lateral firing laser tip or a radial firing laser tip.
8. The system according to any one of claims 1 to 7, wherein the electromagnetic energy is focused using a computer-implemented scanner.
9. The system according to any one of claims 1 to 8, wherein the focused electromagnetic energy reacts with the water to remove the lens (606; 704; 804; 1010; 1106), preferably in which the focused electromagnetic energy does not Remove the lens before the introduction of water into the lens.
ES12838722.2T 2011-10-03 2012-10-02 System for the ablation of a lens Active ES2658360T3 (en)
US201161542702P true 2011-10-03 2011-10-03
US201161542702P 2011-10-03
US201161551826P true 2011-10-26 2011-10-26
US201161551826P 2011-10-26
PCT/US2012/058455 WO2013052481A1 (en) 2011-10-03 2012-10-02 Systems and methods for disruption of an eye lens
ES2658360T3 true ES2658360T3 (en) 2018-03-09
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ES12838722.2T Active ES2658360T3 (en) 2011-10-03 2012-10-02 System for the ablation of a lens
US (2) US9060845B2 (en)
EP (1) EP2763636B1 (en)
JP (2) JP6357418B2 (en)
CA (1) CA2850494C (en)
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WO (1) WO2013052481A1 (en)
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2012-10-02 CA CA2850494A patent/CA2850494C/en active Active
2012-10-02 WO PCT/US2012/058455 patent/WO2013052481A1/en active Application Filing
2012-10-02 JP JP2014534637A patent/JP6357418B2/en active Active
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2012-10-02 EP EP12838722.2A patent/EP2763636B1/en active Active
2012-10-02 ES ES12838722.2T patent/ES2658360T3/en active Active
2015-06-22 US US14/746,794 patent/US20150359672A1/en not_active Abandoned
2018-06-18 JP JP2018115506A patent/JP2018187402A/en active Pending
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