Source: http://www.google.com/patents/US8158427?dq=5631832
Timestamp: 2017-08-17 18:02:57
Document Index: 330679299

Matched Legal Cases: ['Application No. 2', 'Application No. 2', 'Application No. 2', 'Application No. 200480032684', 'Application No. 2006', 'Application No. 11158157', 'Application No. 2011200410', 'Application No. 2006', 'Application No. 2006', 'Application No. 2006']

Patent US8158427 - Cell culture methods and devices utilizing gas permeable materials - Google Patents
Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency...http://www.google.com/patents/US8158427?utm_source=gb-gplus-sharePatent US8158427 - Cell culture methods and devices utilizing gas permeable materials
Publication number US8158427 B2
Application number US 13/194,363
Also published as CA2542116A1, CA2542116C, CN101120083A, CN101120083B, CN103173354A, CN103173354B, EP1687400A2, EP1687400A4, EP2336293A2, EP2336293A3, EP2336293B1, US8158426, US8168432, US8415144, US8697443, US9255243, US9410114, US9441192, US20050106717, US20070254356, US20100255576, US20110129923, US20110287542, US20110287543, US20150329815, US20160024465, WO2005035728A2, WO2005035728A3
Publication number 13194363, 194363, US 8158427 B2, US 8158427B2, US-B2-8158427, US8158427 B2, US8158427B2
Original Assignee Wilson Wolf Manufacturing Corporation
Patent Citations (126), Non-Patent Citations (58), Referenced by (10), Classifications (25), Legal Events (4)
US 8158427 B2
Height of Gas Maximum Maximum Mab Time to Mab
medium permeable live live cells per produced maximum per
Volume above gas surface area cells cm2 of gas per amount of ml of
of permeable to medium per permeable test mab medium
medium material volume ratio device material fixture produced consumed
Normalized Normalized Normalized by Normalized Normalized Normalized Normalized
by height of by gas permeable by by Mab per by time to by
medium maximum surface area to Mab ml attain footprint
above gas live cells medium volume produced of maximum of
permeable per ratio relative to per test medium Mab space
membrane device Si-Culture ™ bag fixture consumed amount occupied
Volume of medium in 8.1 16.2 25.8 51.7 77.6 103.4
Test fixture footprint (cm2) 5.1 5.1 5.1 5.1 5.1 5.1
Ratio of test fixture 100% 50% 32% 16% 11% 8%
Maximum Normalized:
Membrane viable cells Normalized: Maximum
Thickness per cm2 Membrane viable cells
(in) (×106) Thickness per cm2
0.0045 15.2  1.00 1.00
0.016  15.5  3.56 1.02
0.024  13.49 5.33 0.89
0.033  12.0  7.33 0.79
Maximum amount Time to reach
of antibody maximum
Test Fixture Style produced (mg) production (days)
Unrolled Novel Device 289 16
Rolled Novel Device 302 13
Traditional Roller Bottle 33 13
Volume of Devices to produce Volume of
space occupied 221 × 106 space needed
Device per device (cm3) cells in 3 days (cm3)
One novel gas 760 1  760
Surface Number Volume Volume of
area for cell of of medium space
attachment devices needed occupied per
Device (cm2) needed (cm3) device (cm3)
One novel gas 2432 1 420 760
JP2002335946A Title not available
7 Application and File History for U.S. Appl. No. 13/029,762, filed Feb. 17, 2011, inventor Wilson.
8 Babblefish Translation of FR 2666094.
9 * Budhiono et al. "Kinetic aspects of bacterial cellulose formation in nata-de-coco culture system." Carbohydrate Polymers. vol. 40 (1999), pp. 137-143.
10 Canadian Office Action dated Feb. 28, 2011 for Canadian Application No. 2,671,812 filed Dec. 7, 2007, 3 pages.
11 Canadian Office Action dated Mar. 1, 2011 for Canadian Application No. 2,671,967 filed Dec. 7, 2007, 4 pages.
12 Canadian Office Action for Canadian Application No. 2,542,116 dated Aug. 30, 2011.
13 Chinese Office Action for Chinese Application No. 200480032684.8 dated Jul. 1, 2010.
14 CLINIcell® 250 commercial product and related User Instructions V-2, date unknown.
15 English Translation of Japanese Office Action (Notice of Reasons for Rejection) dated Nov. 9, 2010 for Japanese Application No. 2006-534398, 3 pages.
16 European Search Report for European Application No. 11158157 dated Dec. 15, 2011.
17 Examiner's first report on Australian Patent Application No. 2011200410 dated Aug. 30, 2011.
18 File Wrapper for EP Publication No. 1687400 published Aug. 9, 2006, 225 pages.
19 Final Office Action from U.S. Appl. No. 13/029,762 dated Sep. 8, 2011 and respective Response filed Nov. 8, 2011.
20 Genetic Engineering News, "OptiCell Concept for Cell Culture Operations", vol. 20, No. 21, Dec. 2000, 4 pages.
21 Giarratana et al., Cell culture bags allow a large extent of ex vivo expansion of LTC-IC and functional mature cells which can subsequently be frozen: interest for large-scale clinical applications. Bone Marrow Transplantation, Oct. 1998, vol. 22, No. 7, pp. 707-715.
22 International Search Report for International Application No. PCT/US07/25108 dated May 28, 2008.
23 International Search Report for International Application No. PCT/US07/25110 dated May 20, 2008.
24 International Search Report for International Application No. PCT/US2009/049944 dated Jan. 8, 2010.
25 Japanese Office Action for Japanese Application No. 2006-534398 dated May 25, 2010.
26 Japanese Office Action-Final Decision of Rejection dated Aug. 2, 2011 for Japanese Application No. 2006-534398.
27 Japanese Office Action—Final Decision of Rejection dated Aug. 2, 2011 for Japanese Application No. 2006-534398.
28 Jensen Mona D., et al., "Diffusion in Tissue Cultures on Gas-permeable and Impermeable Supports", J. Theor,. Biol. 56, 443-458 (1976).
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30 Jensen, Mona D., "Production of Anchorage-Dependent Cells-Problems and their Possible Solutions," Biotechnology and Bioengineering, vol. XXIII, pp. 2703-2716 (1981).
31 Jensen, Mona D., "Production of Anchorage-Dependent Cells—Problems and their Possible Solutions," Biotechnology and Bioengineering, vol. XXIII, pp. 2703-2716 (1981).
32 LifeCell® X-Fold(TM) Culture Bag commercial product and related literature, © 2000.
33 LifeCell® X-Fold™ Culture Bag commercial product and related literature, © 2000.
34 * Machine Translation of JP-05123182 (May 12, 1993).
35 Mathiot et al, "Increase of hybridoma productivity using an original dialysis culture system." Cytotechnology, vol. 11 (1993) pp. 41-48.
36 Nagel et al., Membrane-based cell culture systems-an alternative to in vivo production of monoclonal antibodies. Dev Biol Stand, 1999, vol. 101, pp. 57-64.
37 Nagel et al., Membrane-based cell culture systems—an alternative to in vivo production of monoclonal antibodies. Dev Biol Stand, 1999, vol. 101, pp. 57-64.
38 Non-Final Office Action from U.S. Appl. No. 13/194,298 dated Sep. 15, 2011 and respective response filed Oct. 17, 2011.
39 Opticell® commercial product and related literature, © 2000.
40 OriGen PermaLife(TM) commercial product and related literature, at least as of Sep. 17, 2004.
41 OriGen PermaLife™ commercial product and related literature, at least as of Sep. 17, 2004.
42 * Papas et al. "High-Density Culture of Human Islets on Top of Silicone Rubber Membranes", Transplantation Proceedings, vol. 37 (2005), pp. 3412-3414.
43 Papas et al., "High-Density Culture of Human Islets on Top of Silicon Rubber Membranes," Transplantation Proceedings, vol. 37 (2005), pp. 3412-3414.
44 petriPERM commercial product and related literature, © 2003.
45 Publication re VueLife(TM) Culture Bags distributed by CellGenix, known to applicant at least as early as Sep. 17, 2004, 4 pages.
46 Publication re VueLife™ Culture Bags distributed by CellGenix, known to applicant at least as early as Sep. 17, 2004, 4 pages.
47 * Pulvertaft et al. "Activation of Lymphocytes." J. Clin. Path., vol. 20 (1967), pp. 795-805.
48 Secker et al., Gas-permeable lifecell tissue culture flasks give improved growth of Helicobacter pylori in a liquid medium. J Clin Microbial, May 1991, vol. 29, No. 5, pp. 1060-1061.
49 Techno Plastics. Web Catalog. Jan 2003. http://web.archive.org/web/20031209110901/http://www/tpp.ch/tis.
50 US 6,465,252, 10/2002, Toner et al. (withdrawn)
51 VectraCell(TM) commercial product and related literature, at least as of Sep. 18, 2004.
52 VectraCell™ commercial product and related literature, at least as of Sep. 18, 2004.
53 Vogler, E. A., "A Compartmentalized Device for the Culture of Animal Cells", Biomat., Art. Cells, Art. Org., 17(5), 597-610 (1989).
54 VueLife(TM) Culture Bag commercial product and related literature, at least as of Oct. 28, 2003.
55 VueLife™ Culture Bag commercial product and related literature, at least as of Oct. 28, 2003.
56 Written Opinion dated Jan. 20, 2011 for International Application No. PCT/US2009/049944 filed Jul. 8, 2009, 2 pages.
57 Written Opinion of the International Searching Authority for International Application No. PCT/US07/25110 dated May 20, 2008.
58 Written Opinion of the International Searching Authority for International Application No. PCT/US2007/025108 dated May 28, 2008.
U.S. Classification 435/401, 435/297.1, 435/402, 435/297.5, 435/304.1, 435/305.1, 435/383, 435/304.3
International Classification C12N5/07, C12M1/18, C12M3/04, C12N, C12M1/12, C12M1/04, C12M3/06
Cooperative Classification C12M23/08, C12N5/0602, C12N2500/02, C12M25/06, C12N5/00, C12M25/14, C12M23/24
European Classification C12M23/24, C12M25/14, C12M23/08
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WILSON, JOHN R.;PAGE, DOUGLAS A.;WELCH, DAN;AND OTHERS;REEL/FRAME:026686/0408