Source: http://www.google.ca/patents/US20030135267
Timestamp: 2017-06-24 19:12:49
Document Index: 544909030

Matched Legal Cases: ['art 33', 'art 33', 'art 33', 'art 33', 'art 33', 'art 33', 'art 33']

Patent US20030135267 - Delayed memory device - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA medical device and a method for providing a change of shape in a part of the body of an organism. The device is insertable into the body of the organism and comprises a member having a preferred state of shape and having a tendency to transfer its shape towards said preferred state of shape when being...http://www.google.ca/patents/US20030135267?utm_source=gb-gplus-sharePatent US20030135267 - Delayed memory deviceAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20030135267 A1Publication typeApplicationApplication numberUS 10/141,348Publication date17 Jul 2003Filing date9 May 2002Priority date11 Jan 2002Also published asUS7192443Publication number10141348, 141348, US 2003/0135267 A1, US 2003/135267 A1, US 20030135267 A1, US 20030135267A1, US 2003135267 A1, US 2003135267A1, US-A1-20030135267, US-A1-2003135267, US2003/0135267A1, US2003/135267A1, US20030135267 A1, US20030135267A1, US2003135267 A1, US2003135267A1InventorsJan Solem, Per KimbladOriginal AssigneeSolem Jan Otto, Kimblad Per OlaExport CitationBiBTeX, EndNote, RefManPatent Citations (99), Referenced by (162), Classifications (20), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetDelayed memory device
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS [0106] FIGS. 1 to 4 show the principle of delayed shortening according to the invention. [0107] In FIG. 1, a shape-changing member 1, here in the form of a thread 1, made of or at least in part including a shape memory material is shown having a curved shape. This shape is the original shape that the shape-changing member 1 “remembers” and will assume when the temperature thereof passes a certain threshold, e.g. exceeds 30° C. [0108] [0108]FIG. 2 shows the shape-changing member 1 of FIG. 1 having been straightened by stretching to a substantially straight shape. [0109] [0109]FIG. 3 illustrates an embodiment of a device according to the invention, where the device is in its non-activated state of shape A. More specifically, by covering the stretched and straight shape-changing member 1 in FIG. 2 with a delay means 2, here in the form of a tube 2 having a sufficiently small inner cross-section, the stretched shape of the shape-changing member 1 can be maintained even when the device is implanted into a human body and the temperature of the shape-changing member 1 thus exceeds the threshold, e.g. 30° C. [0110] The delay means 2 may be flexible enough to follow the curves in e.g. vessels, but has a stiffness, here especially in its radial direction, which withstands the shape-changing force of the shape-changing member 1. Thus, having been implanted into the human body, the shape-changing member 1 of the device will strive towards its original, here curved, shape according to FIG. 1, but is restrained by the delay means 2. [0111] However, by manufacturing the delay means 2 from a resorbable material, the delay means 2 will be resorbed by time and the shape-changing member 1 will resume its original shape when the delay means 2 has been resorbed to such a degree or extent that it cannot restrain the shape-changing member 1 any longer, as schematically illustrated in FIG. 4. Thus, the device has now “been transformed” from its non-activated long state of shape A (FIG. 3), to an activated, shortened state of shape A′ (FIG. 4), where the device consists essentially of the shape-changing member 1 only. [0112] The device in FIG. 3 may be manufactured in the following way. The thread 1 of a shape memory material, e.g. with the shape illustrated in FIG. 2, is programmed to remember the shape illustrated in FIG. 1 by being held in that shape while at the same time being heated to a temperature above said threshold. Upon cooling, beneath the threshold temperature, e.g. down to room temperature, the thread 1 will become more flexible and may more easily be deformed into its previous shape shown in FIG. 2. In this cooled state, the thread 1 is covered by the resorbable tube 2, e.g. by threading the tube 2 onto the thread 1 or by forming the tube 2 around the thread 1. Other embodiments of a device according to the invention may operate and may be manufactured in a corresponding manner. Thus, a shape-changing member of a memory material is first held in a “preferred” state of shape while being heated above a threshold temperature, and then cooled beneath the threshold temperature so that it can easily be deformed into its previous “non-preferred” state of shape. Thereafter, the now “programmed” shape-changing member is “locked” in said non-preferred state of shape by a delay means in such a way that the delay means will obstruct the shape-changing member from resuming its preferred state of shape when being heated again, e.g. in a human body. Referring again to FIG. 3, the inner radius of the tube 2 must not necessarily be so small that the shape-changing member in the form of the thread 1 cannot move at all in the radial direction. Hence, there may be a small radial play in which the shape-changing member 1 can move without consequently being able to change the length of the device to any larger extent. However, the device in FIG. 3 may also be manufactured with essentially no play between the shape-changing member 1 and the inner side of the delay means 2, possibly also with a pretension or bias force from the delay means 2 acting on the shape-changing member 1. [0113] In order to clearly illustrate the shortening of the device, the curved thread 1 is located to the left in FIG. 4, but, after its transformation, the thread 1 may just as well be located anywhere along the remaining parts of the tube 2. [0114] FIGS. 5 to 8 show the principle of delayed elongation according to the invention. [0115] In FIG. 5, a shape-changing member 3, here in the form of a thread 3 of a shape-memory material, is shown having a straight original shape. [0116] [0116]FIG. 6 shows the shape-changing thread member 3 of FIG. 5 when having been folded to a curved shape. [0117] [0117]FIG. 7 illustrates an embodiment of a device according to the invention comprising a thread as illustrated in FIG. 6, where the device is in its non-activated state of shape B. By covering the curved shape-changing member 3 with a delay means 4 in the form of a tube 4 of a resorbable material, the curved shape B can be maintained even when the device is implanted into a human body and strives towards its original straight shape. [0118] As schematically illustrated in FIG. 8, after implantation into the human body, the delay means 4 is resorbed by time and consequently the shape-changing member 3 will be released to resume its original straight shape B′. Thus, the device has now been transformed from its non-activated short state of shape B (FIG. 7) to an activated, elongated state of shape B′ (FIG. 8). [0119] In the illustrated embodiments, the length of the shape-changing member 1;3 is substantially unchanged by the transformation, whereas the shape of the shape-changing member 1;3 is changed so that the length of the device is changed. [0120] According to the invention, the material from which the shape-changing member is made may consist of or at least include Nitinol, which is an alloy composed of nickel (54-60%) and titanium. Small traces of chromium, cobalt, magnesium and iron may also be present in Nitinol. Alternatively, other materials such as Shape Memory Polymers (SMP) could be used as the shape memory material. [0121] Actually, as far as the present invention concerns, the shape-changing material does not have to be a shape memory material. Any superelastic material would function in most applications. For example stainless steel (and other metals) may also be forced into a non-preferred state of shape by means of a resorbable restraining means. [0122] Examples of usable resorbable materials from which the delay means may be made, or that are at least included, are PDS (polydioxanon), Pronova (polyhexaflouropropylen-VDF), Maxon (polyglyconat), Dexon (PGA, polyglycolic acid), Vicryl (polyglactin), PLA (polylactic acid), PDLLA (polydexolactic acid), PLLA (pololevolactic acid), starch, different kinds of sugar, butyric acid, collagen, and collatamp. [0123] Depending on the choice of material, the release of the shape-changing forces may be delayed for a desired period of time. Also design parameters such as the thickness of the resorbable material may be set so that the shape-changing forces are delayed as long as desired. The delay time may vary from e.g. a few days up to several years depending on the application. [0124] The thickness of the delay means may vary along the device, so that the order in which different parts of the device are released by the delay means may be controlled. [0125] FIGS. 9 to 20 show some different embodiments of a device according to the invention. [0126] [0126]FIG. 9 shows an embodiment of a device according to the invention being an alternative arrangement of a device for delayed elongation as compared to the device shown in FIG. 7. Instead of a resorbable tube 4 as in FIG. 7, the resorbable means comprises resorbable crosslinks 6 which hold the shape-changing member 5 in its curved state of shape and thus the device in its non-activated short state of shape C. [0127] Resorbable crosslinks 6 (FIG. 9) may also be combined with a tube 4 (FIG. 7). [0128] [0128]FIG. 10 shows an embodiment of a device according to the invention in its non-activated elongate state of shape D. Here, the shape-changing member 7 is scissors-shaped. A delay means 8 in the form of a tube 8 of resorbable material holds the shape-changing member 7 in a stretched, elongated state of shape and, thus, also the device in its elongate state of shape D. When the delay means 8 has been sufficiently resorbed, the scissors-shaped shape-changing member 7 will resume its original non-stretched shape and the device is transformed to its activated short state of shape D′ (FIG. 11). [0129] [0129]FIG. 10a shows an alternative embodiment of a device according to the invention, where the tube 8 in FIG. 10 is replaced by a delay means in the form of resorbable threads 8 a. The delay means 8 a holds the scissors-shaped shape-changing member 7 a in a stretched, elongate state of shape and, thus, the device in a state of shape corresponding to D in FIG. 10. Referring to FIG. 11a, when the delay means 8 a is cut off by means of resorption, the shape-changing member 7 a will resume its original non-stretched shape and the device is transformed to its activated short state of shape corresponding to D′ in FIG. 11. [0130] [0130]FIG. 12 shows an embodiment of a device according to the invention in its non-activated short state of shape E. A scissors-shaped shape-changing member 9 of the device is held in a short state of shape by means of a delay means in the form of a resorbable thread 10, and, thereby, the whole device is held in its short state of shape E. When the delay means 10 is cut off by means of resorption, the shape-changing member 9 will resume its original elongate shape so that the device is transformed to its activated state of shape E′ (FIG. 13). [0131] [0131]FIG. 14 shows an embodiment of a device according to the invention comprising a shape-changing member in the form of a coil 11 of a shape-memory material having been stretched and arranged in a delay means in the form of a tube 12 of resorbable material. The device is then in its non-activated state of shape F. When the delay means 12 has been sufficiently resorbed, the shape-changing member 11 will resume its original shorter and wider shape as shown in FIG. 16, and the device is transformed to its activated state of shape F′. [0132] In an alternative embodiment shown in FIGS. 15a and 15 b of a device according to the invention, the tube 12 in FIG. 14 is replaced by a resorbable rod 13 provided with grooves 13 a in which a coil 11 is initially wound. The winding of the coil 11 in the grooves 13 a obstructs the coil 11 from resuming its original shape (FIG. 16) and, hence, the device is held in its non-activated state of shape G by the rod 13, as illustrated in FIG. 15a. By resorption of the rod 13 in e.g. a human body, the shape-changing force of the coil 11 is released and the device is transformed to its activated state of shape G′ as shown in FIG. 16. [0133] In another embodiment shown in FIG. 17 of a device according to the invention, a coil 14 is wound around a resorbable rod 15. When the rod 15 is resorbed, the shape-changing forces of the coil 14 will be released so that the coil 14 resumes an original elongate shape, as shown in FIG. 18, whereby the device is transformed from its non-activated state of shape H to its activated state of shape H′. [0134] [0134]FIG. 19 shows an embodiment of a device according to the invention in the form of a patch for closing or obstructing openings, e.g. in the heart of a human or animal body. The patch has a shape-changing member 16 comprising a grid matrix formed by threads made of memory material such as Nitinol or SMP. The threads may be covered individually by biocompatible material such as PTFE or dacron to fill in the gaps between the threads, e.g. in the way shown in FIG. 26 with threads 28 and biocompatible material 29. [0135] The patch in FIG. 19 further comprises a frame 17 for anchoring the patch in the body, e.g. by means of sutures. The frame may be made of any biocompatible material, such as PTFE or dacron. By the use of a cone (not shown), the threads may be spread apart, creating a central opening 16 a in the patch. The cone is advanced until a delay means 18 in the form of a separate ring 18 of a resorbable material, initially positioned on the cone, is positioned in the opening 16 a. The cone is then drawn back and the ring 18 is left in the opening 16 a, restraining the elastic threads in such a way that the central opening 16 a in the patch is maintained. FIG. 19 shows the patch in its non-activated state of shape I with the ring 18 positioned centrally. After implant and sufficient resorption of the restraining ring 18 and after a specified period of time, the central opening in the patch is closed and the patch is activated. [0136] [0136]FIG. 20 shows an alternative embodiment of a device according to the invention in the form of a patch for closing openings. The patch may be constructed by attaching delay means 19 in the form of resorbable threads or bands 19 to the top of a sharp cone and down along the sides of the cone, advancing the cone through the middle of the patch so that the elastic threads 16 are spread out and thus an opening 16 a in the patch is created, and fastening one end of each band to the frame 17 on one side of the patch and the other end of each band 19 to the frame 17 on the other side of the patch, so that each band 19 encircles the opening. The bands 19 could be placed at regular intervals along the circumference of the opening so that they expand a substantially circular hole in the middle of the patch. By means of the resorbable bands 19, the patch is held in its non-activated state of shape J. [0137] It is to be noted that the above-described different embodiments are examples only. There are many possible different forms of a device according to the present invention. For example, the single shape-changing thread in FIGS. 1 to 9 may be replaced by several threads or by one or more bands. The scissors-shaped members 7 and 9 in FIGS. 10 to 13 may be multiplied so as to form a scissor-shaped area, which in turn may be shaped into different forms. The single tube in FIGS. 3, 7, 10 and 14 may be slotted or may be divided into several tube segments. A delay means may also be provided in the form of resorbable glue, which holds parts of the shape-changing member together and in that way delay the change of shape of the device. The number of possible designs of a device according to the invention is, in fact, infinitely great. [0138] Next, an embodiment according to the invention of a device for treatment of mitral annulus dilatation will be described. [0139] The device shown in FIG. 21, being in an elongate and non-activated state of shape K, comprises a shapechanging member 20 in the form of a shape memory metal thread 20, a delay means 21 in the form of a resorbable sheath 21 enclosing the shape memory metal thread 20 for holding it in a straightened state of shape, and preferably self-expandable stents 22 and 23 located at the opposite ends of the device. [0140] The device may include one or more additional shape memory metal threads, e.g. if a stronger shortening force is desired. [0141] The shape memory metal thread 20 may be made of Nitinol, or other similar material which has a memory of an original shape as illustrated in FIG. 22, and can be temporarily forced into another shape, e.g. as illustrated in FIG. 21. [0142] The resorbable sheath 21 is made of PDS, but it may also be made of any other material which is resorbable by the surrounding blood and tissue when applied in a human body and has the required stability and bending properties. The thickness of the resorbable sheath 21 is chosen so that the time needed for the surrounding blood and tissue in the coronary sinus 24 to resorb the resorbable sheath 21 enough for the device to enter its second shorter state of shape K′ is adapted to the time needed for the ends of the device to be fixed within the coronary sinus 24. [0143] The self-expandable stents 22 and 23 may be of conventional type with an elastic cylindrical unit, made of e.g. Nitinol, in an opened zigzag configuration. FIG. 21a shows an alternative embodiment according to the invention of a device for treatment of mitral annulus dilatation. Here, the shape memory metal thread 20 is replaced by a scissors-shaped shape-changing member 20 a. The resorbable sheath 21 may then be replaced by resorbable threads 21 a, like in FIG. 10a. Preferably, self-expandable stents 22 a and 23 a are located at the opposite ends of the device. The state of shape corresponding to K′ in FIG. 22 of the device shown in FIG. 21a is shown in FIG. 22a. [0144] The above-described device as seen in FIG. 21 (or the device as seen in FIG. 21a), is positioned in the coronary sinus 24, shown in FIGS. 23 to 25, in the following way: [0145] An introduction sheath (not shown) of synthetic material may be used to get access to the venous system. Having reached the venous system, a long guiding metal wire (not shown) is advanced through the introduction sheath and via the venous system to the coronary sinus 24. This guiding wire and/or a delivery catheter is provided with X-ray distance markers so that the position of the device in the coronary sinus 24 may be monitored. [0146] The elongate device in FIG. 21 (or the one in FIG. 21a) is locked onto a stent insertion device (not shown) so that the self-expandable stents 22 and 23 (or 22 a and 23 a) are held in a crimped, non-expanded state. Thereafter, the stent insertion device with the elongate device locked thereon is pushed through the introduction sheath and the venous system to the coronary sinus 24 riding on the guiding wire. After having obtained an exact positioning of the elongate device in the coronary sinus 24, as illustrated in FIG. 23 where the mitral valve annulus 25 and the mitral valve 26 having a central gap 27 are shown, the stent insertion device is removed. This will release the self-expandable stents 22 and 23 (or 22 a and 23 a) so that they expand and contact the inner wall of the coronary sinus 24 and thereby provide for a temporary fixation of the elongate device in the coronary sinus 24. Then, the guiding wire and the introduction sheath are removed. [0147] After the insertion, the self-expandable stents 22 and 23 (or 22 a and 23 a) will grow into the wall of the coronary sinus 24 while at the same time the resorbable sheath 21 (or restraining threads 21 a) will be resorbed by the surrounding blood and tissue in the coronary sinus 24, as schematically illustrated in FIG. 24. When the resorbable sheath 21 (or resorbable threads 21 a) has been resorbed to such a degree that it cannot hold the shape memory metal thread 20 (or the scissors-shaped member 20 a) in its straightened state of shape any longer, the self-expandable stents 22 and 23 (or 22 a and 23 a) will be properly fixed into the wall of the coronary sinus 24 as a result of the normal healing process which always occurs after positioning a stent in a blood vessel. Then the shape memory metal thread 20 (or the scissors-shaped member 20 a) retracts and the device is transformed to its activated shorter state of shape K′, as illustrated in FIGS. 22 and 25 (corresponding to FIG. 22a). This shortening of the device makes it bend towards the mitral valve annulus 25, moving the posterior part thereof forward. This movement reduces the circumference of the mitral valve annulus 25 and thereby closes the central gap 27. [0148] The device may be positioned by catheter technique or by any other adequate technique. It may be heparin-coated so as to avoid thrombosis in the coronary sinus 24, thus reducing the need for aspirin, ticlopedine or anticoagulant therapy. At least parts of the device may contain or be covered with drugs like Tacrolimus, Rappamycin or Taxiferol to be delivered into the tissue to prohibit excessive reaction from surrounding tissue. At least parts of the device may be covered with or contain VEGF (Vascular Endothelial Growth Factor) to ensure smooth coverage with endothelial cells. [0149] [0149]FIG. 26 shows one possible arrangement of a part of a contractable area according to the invention. The contractable area comprises a shape-changing member in the form of a grid matrix of shape memory metal threads 28 covered by a delay means in the form of a fabric of a resorbable material (it should be noted that FIG. 26 was previously used to illustrate how the threads of the patches of FIGS. 19 and 20 may be covered with biocompatible material). The fabric comprises resorbable bands 29 which have been weaved together to form an area. Each of the resorbable bands 29 is solid except for a cylindrical hollow space in which a thread 28 is located, just like the thread 1 is located inside the tube 2 in FIG. 3. [0150] The bands 29 restrain the threads 28 from being folded to their original curved shapes as long as the fabric 29 is not resorbed. [0151] Analogously to the device in FIG. 3, there may be a radial play between the inner wall of each band 29 and the thread 28 being located inside it, in which play the thread 28 can move without consequently being able to change the size of the area of the device to any larger extent. [0152] Further, the hollow space in each band 29 must not necessarily be cylindrical. In fact, if the width of each band 29 is small enough as compared to the curves that the threads 28 will assume when being “activated” as a result of the bands 29 being resorbed, the bands 29 may be hollow. [0153] The contractable area in FIG. 26 may be manufactured by threading a thread 28 of a memory material into each resorbable band 29 and then weaving the bands 29 with threads 28 together to form the fabric as illustrated in FIG. 26. [0154] Another possible way of making a contractable area according to the invention would be to arrange threads or bands of a memory material in a grid matrix and to fix the threads or bands together with resorbable crosslinks. The resorbable crosslinks would then restrain the threads or bands from being folded as long as enough resorbable material in the crosslinks is left unresorbed. [0155] A contractable area according to the invention, as the one previously mentioned or as the one shown in FIG. 26, may be formed into a contractable sac as shown in FIGS. 27 to 30, which sac may be used to support a body organ or to restrain a pathologically growing body organ. [0156] FIGS. 27 to 30 illustrate the use of a contractable sac 30 for treatment of pathological heart growth, according to another embodiment of the invention. [0157] Referring to FIG. 27, the sac 30 in its non-activated state of shape L is threaded inside out on a catheter 31 with an anchoring means 32, here in the form of a suction cup 32, and the catheter 31 with the sac 30 is introduced to the apex cordis 33 a of the heart 33 in known manner. [0158] Now referring to FIG. 28, the suction cup 32 is put on the apex cordis 33 a and the sac 30 is pushed off the catheter 31, by means of a catheter instrument (not shown), over the suction cup 32 and up over the heart 33. [0159] Now referring to FIG. 29, when the sac 30 is positioned round the heart 33, the suction cup 32 is pulled out through the bottom of the sac 30 and the catheter 31 is removed from the body. [0160] After a period of time, the resorbable material of the sac 30 will be resorbed and a restraining force by the shape memory metal threads against the heart 33 is released, and hence, the sac 30 is transformed to its activated state of shape L′, as illustrated in FIG. 30. The sac 30 will then press itself tight round the heart 33 and apply a continuous restraining force on the heart 33, thus decreasing the heart size, or at least preventing the heart 33 from growing further. [0161] A contractable area according to the invention can also be used as a contractable sheet for treatment of alveolar sac growth, e.g. in emphysematic pulmonary diseases. [0162] [0162]FIGS. 31 and 32 show the use of an embodiment of a device according to the invention for treatment of alveolar sac growth. [0163] Referring to FIG. 31 a contractable sheet 34 in its non-activated state of shape M is rolled up on a catheter 35, introduced between ribs 36 into the pleural cavity (the space between the pleura of the lung and the pleura of the chest wall), and placed upon the lung 38 surface to be treated. [0164] The contractable sheet 34 may also be inserted into the body by means of open surgery or by means of endoscopic surgery and positioned on an organ surface. [0165] Now referring to FIG. 32, the sheet 34 is then rolled out over the lung 38 and the catheter 35 is removed. [0166] The sheet 34 is arranged to grow fixed to the lung surface so that subsequent contraction of the sheet 34, as a result of the resorbable material of the sheet 34 being resorbed, causes the sheet 34 to compress the lung 38 by means of a force of the shape memory metal threads in the sheet 34. Hence, bullae and areas of enlarged alveolar sacs may be shrunk or eliminated and further pathological growth of alveolar sacs may be prevented. [0167] In this embodiment the contractable sheet 34 contracts in two directions, one approximately vertical and one approximately horizontal. The sheet 34 could also be designed to contract in one direction only, e.g. the most horizontal one, or contract in a circular mode, and still be able to shrink bullous areas and prevent alveolar sacs from growing. [0168] It is to be understood that modifications of the above described devices and methods can be made by people skilled in the art without departing from the spirit and scope of the invention. Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4164046 *16 May 197714 Aug 1979Cooley DentonValve prosthesisUS4655771 *11 Apr 19837 Apr 1987Shepherd Patents S.A.Prosthesis comprising an expansible or contractile tubular bodyUS4954126 *28 Mar 19894 Sep 1990Shepherd Patents S.A.Prosthesis comprising an expansible or contractile tubular bodyUS5006106 *9 Oct 19909 Apr 1991Angelchik Jean PApparatus and method for laparoscopic implantation of anti-reflux prosthesisUS5061275 *29 Dec 198929 Oct 1991Medinvent S.A.Self-expanding prosthesisUS5064435 *28 Jun 199012 Nov 1991Schneider (Usa) Inc.Self-expanding prosthesis having stable axial lengthUS5071407 *12 Apr 199010 Dec 1991Schneider (U.S.A.) Inc.Radially expandable fixation memberUS5104404 *20 Jun 199114 Apr 1992Medtronic, Inc.Articulated stentUS5163955 *24 Jan 199117 Nov 1992AutogenicsRapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignmentUS5170802 *7 Jan 199115 Dec 1992Medtronic, Inc.Implantable electrode for location within a blood vesselUS5209730 *19 Dec 198911 May 1993Scimed Life Systems, Inc.Method for placement of a balloon dilatation catheter across a stenosis and apparatus thereforUS5244491 *5 Oct 199214 Sep 1993Cyprus Power CompanyMethod of extracting zinc lead and silver from brinesUS5304131 *11 Feb 199219 Apr 1994Paskar Larry DCatheterUS5382259 *26 Oct 199217 Jan 1995Target Therapeutics, Inc.Vasoocclusion coil with attached tubular woven or braided fibrous coveringUS5383892 *6 Nov 199224 Jan 1995Meadox FranceStent for transluminal implantationUS5390661 *3 Feb 199321 Feb 1995W. L. Gore & Associates, Inc.Introducer for esophageal probesUS5441515 *23 Apr 199315 Aug 1995Advanced Cardiovascular Systems, Inc.Ratcheting stentUS5449373 *17 Mar 199412 Sep 1995Medinol Ltd.Articulated stentUS5476471 *15 Apr 199419 Dec 1995Mind - E.M.S.G. LtdDevice and method for external correction of insufficient valves in venous junctionsUS5496275 *4 Feb 19945 Mar 1996Advanced Cardiovascular Systems, Inc.Low profile dilatation catheterUS5531779 *24 Jan 19952 Jul 1996Cardiac Pacemakers, Inc.Stent-type defibrillation electrode structuresUS5534007 *18 May 19959 Jul 1996Scimed Life Systems, Inc.Stent deployment catheter with collapsible sheathUS5545209 *30 Jun 199413 Aug 1996Texas Petrodet, Inc.Controlled deployment of a medical deviceUS5571135 *22 Oct 19935 Nov 1996Scimed Life Systems Inc.Stent delivery apparatus and methodUS5584879 *27 Jul 199517 Dec 1996Brigham & Women's HospitalAortic valve supporting deviceUS5591197 *14 Mar 19957 Jan 1997Advanced Cardiovascular Systems, Inc.Expandable stent forming projecting barbs and method for deployingUS5593442 *5 Jun 199514 Jan 1997Localmed, Inc.Radially expansible and articulated vessel scaffoldUS5607444 *9 Jul 19964 Mar 1997Advanced Cardiovascular Systems, Inc.Ostial stent for bifurcationsUS5674280 *12 Oct 19957 Oct 1997Smith & Nephew, Inc.Valvular annuloplasty rings of a biocompatible low elastic modulus titanium-niobium-zirconium alloyUS5713949 *6 Aug 19963 Feb 1998Jayaraman; SwaminathanMicroporous covered stents and method of coatingUS5741274 *22 Dec 199521 Apr 1998Cardio Vascular Concepts, Inc.Method and apparatus for laparoscopically reinforcing vascular stent-graftsUS5817126 *17 Mar 19976 Oct 1998Surface Genesis, Inc.Compound stentUS5824071 *12 Feb 199720 Oct 1998Circulation, Inc.Apparatus for treatment of ischemic heart disease by providing transvenous myocardial perfusionUS5876419 *15 Oct 19972 Mar 1999Navius CorporationStent and method for making a stentUS5876433 *29 May 19962 Mar 1999Ethicon, Inc.Stent and method of varying amounts of heparin coated thereon to control treatmentUS5891108 *12 Sep 19946 Apr 1999Cordis CorporationDrug delivery stentUS5911732 *10 Mar 199715 Jun 1999Johnson & Johnson Interventional Systems, Co.Articulated expandable intraluminal stentUS5919233 *25 Jun 19976 Jul 1999Ethicon, Inc.Flexible implantUS5935081 *20 Jan 199810 Aug 1999Cardiac Pacemakers, Inc.Long term monitoring of acceleration signals for optimization of pacing therapyUS5954761 *25 Mar 199721 Sep 1999Intermedics Inc.Implantable endocardial lead assembly having a stentUS5961545 *17 Jan 19975 Oct 1999Meadox Medicals, Inc.EPTFE graft-stent composite deviceUS5980552 *4 Dec 19969 Nov 1999Medinol Ltd.Articulated stentUS6006122 *25 Sep 199721 Dec 1999Medtronic, Inc.Medical electrical leadUS6013854 *16 Jun 199511 Jan 2000Terumo Kabushiki KaishaIndwelling stent and the method for manufacturing the sameUS6019739 *18 Jun 19981 Feb 2000Baxter International Inc.Minimally invasive valve annulus sizerUS6027525 *23 May 199722 Feb 2000Samsung Electronics., Ltd.Flexible self-expandable stent and method for making the sameUS6051020 *29 Oct 199718 Apr 2000Boston Scientific Technology, Inc.Bifurcated endoluminal prosthesisUS6071292 *28 Jun 19976 Jun 2000Transvascular, Inc.Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structuresUS6077296 *4 Mar 199820 Jun 2000Endologix, Inc.Endoluminal vascular prosthesisUS6093203 *13 May 199825 Jul 2000Uflacker; RenanStent or graft support structure for treating bifurcated vessels having different diameter portions and methods of use and implantationUS6110100 *22 Apr 199829 Aug 2000Scimed Life Systems, Inc.System for stress relieving the heart muscle and for controlling heart functionUS6123699 *5 Sep 199726 Sep 2000Cordis Webster, Inc.Omni-directional steerable catheterUS6161029 *8 Mar 199912 Dec 2000Medtronic, Inc.Apparatus and method for fixing electrodes in a blood vesselUS6161543 *15 Oct 199719 Dec 2000Epicor, Inc.Methods of epicardial ablation for creating a lesion around the pulmonary veinsUS6165169 *15 Apr 199926 Dec 2000Ep Technologies, Inc.Systems and methods for identifying the physical, mechanical, and functional attributes of multiple electrode arraysUS6171329 *28 Aug 19989 Jan 2001Gore Enterprise Holdings, Inc.Self-expanding defect closure device and method of making and usingUS6183411 *21 Sep 19986 Feb 2001Myocor, Inc.External stress reduction device and methodUS6203556 *5 Aug 199920 Mar 2001Kensey Nash CorporationTransmyocardial revascularization system and method of useUS6210432 *30 Jun 19993 Apr 2001Jan Otto SolemDevice and method for treatment of mitral insufficiencyUS6221103 *30 Sep 199824 Apr 2001The University Of CincinnatiDevice and method for restructuring heart chamber geometryUS6248119 *22 Jun 200019 Jun 2001Jan Otto SolemDevice and method for endoscopic vascular surgeryUS6250308 *17 Sep 199926 Jun 2001Cardiac Concepts, Inc.Mitral valve annuloplasty ring and method of implantingUS6264602 *9 Mar 200024 Jul 2001Myocor, Inc.Stress reduction apparatus and methodUS6264691 *23 Apr 199924 Jul 2001Shlomo GabbayApparatus and method for supporting a heart valveUS6325826 *4 Jun 19994 Dec 2001Advanced Stent Technologies, Inc.Extendible stent apparatusUS6343605 *8 Aug 20005 Feb 2002Scimed Life Systems, Inc.Percutaneous transluminal myocardial implantation device and methodUS6350277 *15 Jan 199926 Feb 2002Scimed Life Systems, Inc.Stents with temporary retaining bandsUS6368348 *15 May 20009 Apr 2002Shlomo GabbayAnnuloplasty prosthesis for supporting an annulus of a heart valveUS6402679 *14 Nov 200011 Jun 2002Myocor, Inc.External stress reduction device and methodUS6402680 *27 Apr 200111 Jun 2002Myocor, Inc.Stress reduction apparatus and methodUS6402781 *31 Jan 200011 Jun 2002MitralifePercutaneous mitral annuloplasty and cardiac reinforcementUS6629534 *7 Apr 20007 Oct 2003Evalve, Inc.Methods and apparatus for cardiac valve repairUS6890353 *22 Mar 200210 May 2005Viacor, Inc.Method and apparatus for reducing mitral regurgitationUS6908478 *5 Dec 200121 Jun 2005Cardiac Dimensions, Inc.Anchor and pull mitral valve device and methodUS6989028 *30 Jan 200224 Jan 2006Edwards Lifesciences AgMedical system and method for remodeling an extravascular tissue structureUS6997951 *24 Dec 200214 Feb 2006Edwards Lifesciences AgMethod and device for treatment of mitral insufficiencyUS7011682 *5 Aug 200314 Mar 2006Edwards Lifesciences AgMethods and apparatus for remodeling an extravascular tissue structureUS7090695 *26 Nov 200215 Aug 2006Edwards Lifesciences AgMethod for treatment of mitral insufficiencyUS20010018611 *5 Feb 200130 Aug 2001Solem Jan OttoMethod and device for treatment of mitral insufficiencyUS20010044568 *19 Jul 200122 Nov 2001Langberg Jonathan J.Endoluminal ventricular retentionUS20020016628 *1 Oct 20017 Feb 2002Langberg Jonathan J.Percutaneous mitral annuloplasty with hemodynamic monitoringUS20020019660 *26 Jul 200114 Feb 2002Marc GianottiMethods and apparatus for a curved stentUS20020022880 *13 Apr 200121 Feb 2002Melvin David B.Device and method for restructuring heart chamber geometryUS20020111647 *19 Oct 200115 Aug 2002Khairkhahan Alexander K.Adjustable left atrial appendage occlusion deviceUS20020188170 *25 Apr 200212 Dec 2002Santamore William P.Prevention of myocardial infarction induced ventricular expansion and remodelingUS20030120341 *21 Dec 200126 Jun 2003Hani ShennibDevices and methods of repairing cardiac valvesUS20030171806 *11 Mar 200211 Sep 2003Cardiac Dimensions, Inc.Device, assembly and method for mitral valve repairUS20030204138 *25 Apr 200230 Oct 2003Choi Steven B.Dual balloon telescoping guiding catheterUS20040073302 *27 May 200315 Apr 2004Jonathan RourkeMethod and apparatus for improving mitral valve functionUS20040102840 *13 Nov 200327 May 2004Solem Jan OttoMethod and device for treatment of mitral insufficiencyUS20040102841 *17 Nov 200327 May 2004Langberg Jonathan J.Percutaneous mitral annuloplasty with cardiac rhythm managementUS20040176840 *23 Mar 20049 Sep 2004Langberg Jonathan J.Percutaneous mitral annuloplasty with hemodynamic monitoringUS20050043792 *29 Sep 200424 Feb 2005Edwards Lifesciences AgDevice and method for treatment of mitral insufficiencyUS20050060030 *19 Jul 200417 Mar 2005Lashinski Randall T.Remotely activated mitral annuloplasty system and methodsUS20050080483 *20 Dec 200214 Apr 2005Solem Jan OttoDelayed memory deviceUS20050096740 *1 Nov 20045 May 2005Edwards Lifesciences AgTransluminal mitral annuloplastyUS20060116756 *4 Jan 20061 Jun 2006Solem Jan OMethod and device for treatment of mitral insufficiencyUS20060116757 *13 Jan 20061 Jun 2006Randall LashinskiMethods and apparatus for remodeling an extravascular tissue structureUS20060184230 *30 Jan 200617 Aug 2006Solem Jan ODelayed memory device* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6793673 *26 Dec 200221 Sep 2004Cardiac Dimensions, Inc.System and method to effect mitral valve annulus of a heartUS679700111 Mar 200228 Sep 2004Cardiac Dimensions, Inc.Device, assembly and method for mitral valve repairUS68245628 May 200230 Nov 2004Cardiac Dimensions, Inc.Body lumen device anchor, device and assemblyUS69084785 Dec 200121 Jun 2005Cardiac Dimensions, Inc.Anchor and pull mitral valve device and methodUS69491221 Nov 200127 Sep 2005Cardiac Dimensions, Inc.Focused compression mitral valve device and methodUS69602292 May 20031 Nov 2005Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS696692610 Sep 200322 Nov 2005Cardiac Dimensions, Inc.Mitral valve therapy assembly and methodUS697699530 Jan 200220 Dec 2005Cardiac Dimensions, Inc.Fixed length anchor and pull mitral valve device and methodUS699795124 Dec 200214 Feb 2006Edwards Lifesciences AgMethod and device for treatment of mitral insufficiencyUS700417617 Oct 200328 Feb 2006Edwards Lifesciences AgHeart valve leaflet locatorUS70049586 Mar 200228 Feb 2006Cardiac Dimensions, Inc.Transvenous staples, assembly and method for mitral valve repairUS727067624 Aug 200418 Sep 2007Cardiac Dimensions, Inc.Mitral valve therapy device, system and methodUS73144853 Feb 20031 Jan 2008Cardiac Dimensions, Inc.Mitral valve device using conditioned shape memory alloyUS73578156 May 200515 Apr 2008Micardia CorporationDynamically adjustable implants and methods for reshaping tissueUS73611906 May 200522 Apr 2008Micardia CorporationAdjustable cardiac valve implant with coupling mechanismUS73779416 May 200527 May 2008Micardia CorporationAdjustable cardiac valve implant with selective dimensional adjustmentUS73963646 May 20058 Jul 2008Micardia CorporationCardiac valve implant with energy absorbing materialUS75009893 Jun 200510 Mar 2009Edwards Lifesciences Corp.Devices and methods for percutaneous repair of the mitral valve via the coronary sinusUS75105776 May 200531 Mar 2009Micardia CorporationAdjustable cardiac valve implant with ferromagnetic materialUS753622822 Mar 200719 May 2009Micardia CorporationActivation device for dynamic ring manipulationUS7591826 *28 Dec 200022 Sep 2009Cardiac Dimensions, Inc.Device implantable in the coronary sinus to provide mitral valve therapyUS7637946 *1 Feb 200729 Dec 2009Edwards Lifesciences CorporationCoiled implant for mitral valve repairUS76662247 Jul 200523 Feb 2010Edwards Lifesciences LlcDevices and methods for heart valve treatmentUS767428724 Aug 20069 Mar 2010Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS76781451 Jul 200516 Mar 2010Edwards Lifesciences LlcDevices and methods for heart valve treatmentUS769551219 Jul 200413 Apr 2010Edwards Lifesciences AgRemotely activated mitral annuloplasty system and methodsUS77132986 May 200511 May 2010Micardia CorporationMethods for treating cardiac valves with adjustable implantsUS771795420 Aug 200718 May 2010Edwards Lifesciences AgDevice and method for treatment of mitral insufficiencyUS772266815 Feb 200825 May 2010Micardia CorporationCardiac valve implant with energy absorbing materialUS775863918 Jan 200720 Jul 2010Cardiac Dimensions, Inc.Mitral valve device using conditioned shape memory alloyUS779449619 Dec 200314 Sep 2010Cardiac Dimensions, Inc.Tissue shaping device with integral connector and crimpUS780692821 Mar 20075 Oct 2010Edwards Lifesciences CorporationDiagnostic kit to assist with heart valve annulus adjustmentUS781463512 May 200619 Oct 2010Cardiac Dimensions, Inc.Method of making a tissue shaping deviceUS782884324 Aug 20049 Nov 2010Cardiac Dimensions, Inc.Mitral valve therapy device, system and methodUS783772819 Dec 200323 Nov 2010Cardiac Dimensions, Inc.Reduced length tissue shaping deviceUS783772920 Sep 200423 Nov 2010Cardiac Dimensions, Inc.Percutaneous mitral valve annuloplasty delivery systemUS78578462 May 200328 Dec 2010Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS788353923 Apr 20028 Feb 2011Edwards Lifesciences LlcHeart wall tension reduction apparatus and methodUS7887582 *5 May 200415 Feb 2011Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS79933975 Apr 20049 Aug 2011Edwards Lifesciences AgRemotely adjustable coronary sinus implantUS800659411 Aug 200830 Aug 2011Cardiac Dimensions, Inc.Catheter cutting toolUS806235819 Nov 200422 Nov 2011Cardiac Dimensions, Inc.Body lumen device anchor, device and assemblyUS807080525 Jan 20106 Dec 2011Edwards Lifesciences LlcDevices and methods for heart valve treatmentUS80756088 Jan 200813 Dec 2011Cardiac Dimensions, Inc.Medical device delivery systemUS807561620 Dec 200213 Dec 2011Edwards Lifesciences AgApparatus for applying a compressive load on body tissueUS810082022 Aug 200724 Jan 2012Edwards Lifesciences CorporationImplantable device for treatment of ventricular dilationUS81099844 Jan 20067 Feb 2012Edwards Lifesciences AgMethod and device for treatment of mitral insufficiencyUS81728988 Mar 20108 May 2012Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS818252920 Sep 200422 May 2012Cardiac Dimensions, Inc.Percutaneous mitral valve annuloplasty device delivery methodUS825737617 Jun 20094 Sep 2012Syntach AgDevice, a kit and a method for treatment of disorders in the heart rhythm regulation systemUS82678528 Jul 201018 Sep 2012Edwards Lifesciences, LlcHeart wall tension reduction apparatus and methodUS8394128 *27 Apr 201112 Mar 2013Simpirica Spine, Inc.Modulated constraining apparatus and methods of useUS84092683 Feb 20102 Apr 2013Syntach AgElectrical conduction block implant deviceUS843997118 Dec 200914 May 2013Cardiac Dimensions, Inc.Adjustable height focal tissue deflectorUS846017311 Sep 201211 Jun 2013Edwards Lifesciences, LlcHeart wall tension reduction apparatus and methodUS85066242 Dec 201113 Aug 2013Edwards Lifesciences, LlcDevices and methods for heart valve treatmentUS87090746 Feb 201229 Apr 2014Edwards Lifesciences AgMethod and device for treatment of mitral insufficiencyUS876462624 Jan 20121 Jul 2014Edwards Lifesciences CorporationMethod of treating a dilated ventricleUS88406582 Mar 200923 Sep 2014Syntach AgElectrical conduction block implant deviceUS8870909 *24 Jul 201228 Oct 2014Microvention, Inc.Aneurysm treatment device and method of useUS897452519 Oct 201010 Mar 2015Cardiac Dimensions Pty. Ltd.Tissue shaping deviceUS902309425 Jun 20085 May 2015Microvention, Inc.Self-expanding prosthesisUS91013383 May 200711 Aug 2015Mayo Foundation For Medical Education And ResearchSoft body tissue remodeling methods and apparatusUS9138336 *4 Oct 201122 Sep 2015The Regents Of The University Of CaliforniaExpandable distension device for hollow organ growthUS9271734 *14 May 20131 Mar 2016Covidien LpMethods and devices for sheath compressionUS929548417 Jun 200929 Mar 2016Syntach AgDevice, a kit and a method for treatment of disorders in the heart rhythm regulation systemUS93206009 Mar 201526 Apr 2016Cardiac Dimensions Pty. Ltd.Tissue shaping deviceUS939896717 Jan 200626 Jul 2016Syntach AgElectrical conduction block implant deviceUS947460819 Nov 200425 Oct 2016Cardiac Dimensions Pty. Ltd.Body lumen device anchor, device and assemblyUS949227730 Aug 200515 Nov 2016Mayo Foundation For Medical Education And ResearchSoft body tissue remodeling methods and apparatusUS952661617 Jul 200627 Dec 2016Cardiac Dimensions Pty. Ltd.Mitral valve annuloplasty device with twisted anchorUS959718622 Apr 201621 Mar 2017Cardiac Dimensions Pty. Ltd.Tissue shaping deviceUS9622753 *25 Sep 201418 Apr 2017Microvention, Inc.Aneurysm treatment device and method of useUS20020087173 *28 Dec 20004 Jul 2002Alferness Clifton A.Mitral valve constricting device, system and methodUS20020151961 *30 Jan 200217 Oct 2002Lashinski Randall T.Medical system and method for remodeling an extravascular tissue structureUS20030083538 *1 Nov 20011 May 2003Cardiac Dimensions, Inc.Focused compression mitral valve device and methodUS20030171776 *6 Mar 200211 Sep 2003Cardiac Dimensions, Inc.Transvenous staples, assembly and method for mitral valve repairUS20030212453 *8 May 200213 Nov 2003Cardiac Dimensions, Inc.Body lumen device anchor, device and assemblyUS20030225454 *2 May 20034 Dec 2003Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS20030236569 *2 May 200325 Dec 2003Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS20040010305 *2 May 200315 Jan 2004Cardiac Dimensions, Inc.Device and method for modifying the shape of a body organUS20040039443 *24 Dec 200226 Feb 2004Solem Jan OttoMethod and device for treatment of mitral insufficiencyUS20040111095 *5 Dec 200210 Jun 2004Cardiac Dimensions, Inc.Medical device delivery systemUS20040127980 *26 Dec 20021 Jul 2004Cardiac Dimensions, Inc.System and method to effect the mitral valve annulus of a heartUS20040138744 *5 Aug 200315 Jul 2004Randall LashinskiTransluminal mitral annuloplasty with active anchoringUS20040153052 *10 Sep 20035 Aug 2004Cardiac Dimensions, Inc.Mitral valve therapy assembly and methodUS20040153147 *3 Feb 20035 Aug 2004Cardiac Dimensions, Inc.Mitral valve device using conditioned shape memory alloyUS20040158321 *12 Feb 200312 Aug 2004Cardiac Dimensions, Inc.Method of implanting a mitral valve therapy deviceUS20040186566 *17 Mar 200423 Sep 2004Hindrichs Paul J.Body tissue remodeling methods and apparatusUS20040254600 *25 Feb 200416 Dec 2004David ZarbatanyMethods and devices for endovascular mitral valve correction from the left coronary sinusUS20050004667 *10 May 20046 Jan 2005Cardiac Dimensions, Inc. A Delaware CorporationDevice, system and method to affect the mitral valve annulus of a heartUS20050027351 *19 Dec 20033 Feb 2005Cardiac Dimensions, Inc. A Washington CorporationMitral valve regurgitation treatment device and methodUS20050038507 *24 Aug 200417 Feb 2005Alferness Clifton A.Mitral valve therapy device, system and methodUS20050065598 *4 Aug 200424 Mar 2005Mathis Mark L.Device, assembly and method for mitral valve repairUS20050080483 *20 Dec 200214 Apr 2005Solem Jan OttoDelayed memory deviceUS20050085903 *17 Oct 200321 Apr 2005Jan LauHeart valve leaflet locatorUS20050096666 *20 Sep 20045 May 2005Gordon Lucas S.Percutaneous mitral valve annuloplasty delivery systemUS20050096740 *1 Nov 20045 May 2005Edwards Lifesciences AgTransluminal mitral annuloplastyUS20050119673 *20 Sep 20042 Jun 2005Gordon Lucas S.Percutaneous mitral valve annuloplasty device delivery methodUS20050137449 *19 Dec 200323 Jun 2005Cardiac Dimensions, Inc.Tissue shaping device with self-expanding anchorsUS20050137685 *19 Dec 200323 Jun 2005Cardiac Dimensions, Inc., A Washington CorporationReduced length tissue shaping deviceUS20050149179 *19 Nov 20047 Jul 2005Mathis Mark L.Body lumen device anchor, device and assemblyUS20050149180 *19 Nov 20047 Jul 2005Mathis Mark L.Body lumen device anchor, device and assemblyUS20050209690 *18 May 200522 Sep 2005Mathis Mark LBody lumen shaping device with cardiac leadsUS20050222678 *5 Apr 20046 Oct 2005Lashinski Randall TRemotely adjustable coronary sinus implantUS20050267570 *27 May 20051 Dec 2005Shadduck John HEndovascular occlusion devices and methods of useUS20050288776 *6 May 200529 Dec 2005Emanuel ShaoulianAdjustable cardiac valve implant with coupling mechanismUS20050288777 *6 May 200529 Dec 2005Rhee Richard SThermal conductor for adjustable cardiac valve implantUS20050288778 *6 May 200529 Dec 2005Emanuel ShaoulianSelectively adjustable cardiac valve implantsUS20050288779 *6 May 200529 Dec 2005Emanuel ShaoulianMethods for treating cardiac valves with adjustable implantsUS20050288781 *6 May 200529 Dec 2005Shahram MoaddebAdjustable cardiac valve implant with ferromagnetic materialUS20050288782 *6 May 200529 Dec 2005Shahram MoaddebCardiac valve implant with energy absorbing materialUS20050288783 *6 May 200529 Dec 2005Emanuel ShaoulianMethods for treating cardiac valves using magnetic fieldsUS20060015178 *14 Jul 200519 Jan 2006Shahram MoaddebImplants and methods for reshaping heart valvesUS20060020335 *23 Sep 200526 Jan 2006Leonard KowalskySystem and method to effect the mitral valve annulus of a heartUS20060030882 *7 Oct 20059 Feb 2006Adams John MTransvenous staples, assembly and method for mitral valve repairUS20060116756 *4 Jan 20061 Jun 2006Solem Jan OMethod and device for treatment of mitral insufficiencyUS20060116757 *13 Jan 20061 Jun 2006Randall LashinskiMethods and apparatus for remodeling an extravascular tissue structureUS20060116758 *13 Feb 20061 Jun 2006Gary SwinfordDevice, System and Method to Affect the Mitral Valve Annulus of a HeartUS20060129051 *9 Dec 200415 Jun 2006Rowe Stanton JDiagnostic kit to assist with heart valve annulus adjustmentUS20060167544 *19 Jan 200627 Jul 2006Cardiac Dimensions, Inc.Tissue Shaping DeviceUS20060178725 *17 Jan 200610 Aug 2006Sinus Rhythm Technologies, Inc.Electrical conduction block implant deviceUS20060184230 *30 Jan 200617 Aug 2006Solem Jan ODelayed memory deviceUS20060206140 *23 Feb 200614 Sep 2006Samuel ShaolianAdjustable embolic aneurysm coilUS20060212113 *23 Feb 200621 Sep 2006Shaolian Samuel MExternally adjustable endovascular graft implantUS20060238019 *21 Apr 200526 Oct 2006Mark YuBrakable wheel hub deviceUS20060241747 *6 May 200526 Oct 2006Emanuel ShaoulianDynamically adjustable implants and methods for reshaping tissueUS20060252983 *10 Feb 20069 Nov 2006Lembo Nicholas JDynamically adjustable gastric implants and methods of treating obesity using dynamically adjustable gastric implantsUS20060276812 *3 Apr 20067 Dec 2006Hill James WDynamic reinforcement of the lower esophageal sphincterUS20060276890 *3 Jun 20057 Dec 2006Solem Jan ODevices and methods for percutaneous repair of the mitral valve via the coronary sinusUS20070038297 *11 Aug 200615 Feb 2007Bobo Donald E JrMedical implant with reinforcement mechanismUS20070055368 *31 Aug 20068 Mar 2007Richard RheeSlotted annuloplasty ringUS20070073391 *28 Sep 200529 Mar 2007Henry BourangSystem and method for delivering a mitral valve repair deviceUS20070168023 *21 Mar 200719 Jul 2007Rowe Stanton JDiagnostic kit to assist with heart valve annulus adjustmentUS20070173926 *11 Dec 200626 Jul 2007Bobo Donald E JrAnchoring system for medical implantUS20070185572 *1 Feb 20079 Aug 2007Jan Otto SolemCoiled implant for mitral valve repairUS20070282375 *3 May 20076 Dec 2007St. Jude Medical, Inc.Soft body tissue remodeling methods and apparatusUS20070288090 *20 Aug 200713 Dec 2007Solem Jan ODevice and method for treatment of mitral insufficiencyUS20080065205 *11 Sep 200613 Mar 2008Duy NguyenRetrievable implant and method for treatment of mitral regurgitationUS20080087608 *10 Oct 200617 Apr 2008Multiphase Systems IntegrationCompact multiphase inline bulk water separation method and system for hydrocarbon productionUS20080183285 *14 Feb 200831 Jul 2008Micardia CorporationAdjustable cardiac valve implant with selective dimensional adjustmentUS20080200981 *14 Mar 200821 Aug 2008Micardia CorporationAdjustable cardiac valve implant with coupling mechanismUS20080215145 *15 Feb 20084 Sep 2008Micardia CorporationCardiac valve implant with energy absorbing materialUS20080221673 *15 Feb 200811 Sep 2008Donald BoboMedical implant with reinforcement mechanismUS20080255447 *16 Apr 200716 Oct 2008Henry BourangDiagnostic catheterUS20090163941 *17 May 200625 Jun 2009Syntach AgBistable Device, A Kit And A Method For Treatment Of Disorders In The Heart Rhythm Regulation SystemUS20090182418 *31 Dec 200816 Jul 2009Jan Otto SolemTreatment of mitral insufficiencyUS20100016877 *17 May 200621 Jan 2010Syntach AgControllable Device, A Kit And A Method For Treatment Of Disorders In The Heart Rhythm Regulation SystemUS20100185273 *30 Mar 201022 Jul 2010Edwards Lifesciences AgDevice and method for treatment of mitral insufficiencyUS20100211155 *3 Feb 201019 Aug 2010William SwansonElectrical Conduction Block Implant DeviceUS20110230962 *8 Nov 201022 Sep 2011Micardia CorporationDynamically adjustable suture and chordae tendinaeUS20120083820 *4 Oct 20115 Apr 2012The Regents Of The University Of CaliforniaExpandable distension device for hollow organ growthUS20120109199 *27 Apr 20113 May 2012Simpirica Spine, Inc.Modulated constraining apparatus and methods of useUS20120289993 *24 Jul 201215 Nov 2012Cox Brian JAneurysm Treatment Device And Method Of UseUS20130211317 *24 Jan 201315 Aug 2013Syntach AgDevice, A Kit And A Method For Treatment Of Disorders In The Heart Rhythm Regulation SystemUS20130253549 *14 May 201326 Sep 2013Covidien LpMethods and devices for sheath compressionUS20140052186 *6 Feb 201320 Feb 2014Simpirica Spine, Inc.Modulated constraining apparatus and methods of useUS20150142042 *25 Sep 201421 May 2015Microvention, Inc.Aneurysm Treatment Device And Method Of UseEP1691738B1 †23 Sep 200413 Nov 2013Medtronic Xomed, Inc.Airway implantEP1691738B2 †23 Sep 20045 Apr 2017Medtronic Xomed, Inc.Airway implantWO2002053206A2 *27 Dec 200111 Jul 2002Cardiac Dimensions, Inc.Mitral valve constricting device, system and methodWO2002053206A3 *27 Dec 200124 Dec 2003Cardiac Dimensions IncMitral valve constricting device, system and method* Cited by examiner, † Cited by third partyClassifications U.S. Classification623/1.18International ClassificationA61F2/82, A61F2/04, A61F2/07, A61F2/848, A61F2/26, A61F2/24, A61F2/02Cooperative ClassificationA61F2/26, A61F2/2481, A61F2002/826, A61F2210/0004, A61F2/07, A61F2002/8483, A61F2002/043, A61F2/2451, A61F2002/828, A61F2002/072European ClassificationA61F2/24W2, A61F2/24R4Legal EventsDateCodeEventDescription24 Dec 2002ASAssignmentOwner name: SYNDEON AB, SWEDENFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SOLEM, JAN OTTO;REEL/FRAME:013611/0429Effective date: 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