Source: http://www.science.gov/topicpages/a/administration+msha+informational.html
Timestamp: 2016-10-22 19:51:24
Document Index: 241746731

Matched Legal Cases: ['§ 47', '§ 47', '§ 1', '§ 1', '§ 1', '§ 1', '§ 1', '§ 22', '§ 22', '§ 22', '§ 23', '§ 19', '§ 19', '§ 23', '§ 19', '§ 50', '§ 50', '§ 50', '§ 250']

administration msha informational: Topics by Science.gov
Sample records for administration msha informational
30 CFR 47.82 - Disclosure of information to MSHA.
... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Disclosure of information to MSHA. 47.82 Section 47.82 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND TRAINING HAZARD COMMUNICATION (HazCom) Making HazCom Information Available § 47.82 Disclosure...
... TRAINING HAZARD COMMUNICATION (HazCom) Trade Secret Hazardous Chemical § 47.82 Disclosure of information to MSHA. (a) Even if the operator has a trade secret claim, the operator must disclose to MSHA, upon... make a trade secret claim, no later than at the time the information is provided to MSHA, so that...
Chirdon, D.C.
The hazardous nature of the underground mining environment necessitates the use of equipment and mining products designed to ensure safe usage in this hostile environment. Title 30, code of federal regulations (30 CFR) includes requirements that all equipment and products intended for use in potentially gassy areas of underground mines be approved by the mine safety and health administration (MSHA). Design and performance requirements for many of the products intended for use in the underground environment are also part of 30 CFR. This paper describes the processes available to potential applicants for obtaining MSHA approval. Emphasis is placed on ventilation-related products. A program available to operators for modifying approved equipment is described. A proposed regulation that would broaden the scope of design standards accepted by MSHA is discussed.
MSHA streamlines equipment approval and certification
The author attempts to define the role of the Mine Safety and Health Administration (MSHA) as the ever-present watchdog of American miners' health and safety in two major ways: federal (MSHA) inspectors visit US mines several times a year to monitor compliance with regulations, including permissibility requirements and procedures; and MSHA conducts approval and certification activities on all hazardous instrumentation and equipment to be used in underground coal mining. Now that MSHA has achieved the latest in test apparatus and procedures, the author believes there is a challenge to improve the approval and certification process even more in the years ahead.
75 FR 79029 - Proposed Extension of Existing Information Collection; Request for MSHA Individual Identification...
...The Department of Labor, as part of its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies with an opportunity to comment on proposed and/or continuing collections of information in accordance with the Paperwork Reduction Act of 1995 [44 U.S.C. 3506(c)(2)(A)]. This program helps to assure......
30 CFR 1.3 - Use of letters and acronym MSHA.
... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...
... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Material required for MSHA records. 22.8 Section 22.8 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.8 Material required for...
76 FR 28094 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Escape and...
... Federal Register on December 17, 2011 (75 FR 79034). Interested parties are encouraged to send comments to... Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Escape... Officer for the Department of Labor, Mine Safety and Health Administration (MSHA), Office of...
76 FR 4132 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Slope and...
... in the Federal Register on September 16, 2010 (Vol. 75 FR 56562). Interested parties are encouraged... submission of the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR... Safety and Health Administration (MSHA), Office of Management and Budget, Room 10235, Washington,...
76 FR 52015 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Permissible...
..., see the related notice published in the Federal Register on April 29, 2011 (76 FR 24060). Interested... Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled... Officer for the U.S. Department of Labor, Mine Safety and Health Administration (MSHA), Office...
76 FR 54257 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Hazard...
... Federal Register on April 15, 2011 (76 FR 21410). Interested parties are encouraged to send comments to... and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Hazard.... Department of Labor, Mine Safety and Health Administration (MSHA), Office of Management and Budget,...
76 FR 20711 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Application...
... (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored information collection... Safety and Health Administration (MSHA), Office of Management and Budget, Room 10235, Washington, DC... sanitary flush toilet facilities in a location that is convenient for use of the miners. See CFR...
MSHA releases data on CM crushing accidents
Zhu, Hechen; Wang, Shiqiang; Shen, Lei; Wang, Wei; Zhao, Feng; Cao, Tongwa
To evaluate the effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) injection on the survival rate of rats post cecal ligation and puncture (CLP), Sprague-Dawley (SD) rats were subcutaneously injected with 0.125 ml, 0.25 ml or 0.5 ml PA-MSHA for 8 days or 16 days before CLP. The survival rate and physiological appearance of rats in each group were monitored daily post CLP. The expression of Toll-like receptor 4 (TLR4) and cytokines related to inflammation was evaluated. We found that the 0.5 ml-8d (0.5 ml PA-MSHA injected for 8 days) group had the highest 7-day survival rate (91.7%), which was significantly improved compared with the CLP-only group (33.3%). Furthermore, our results showed that PA-MSHA effectively increased serum pro-inflammatory mediators (TNF-α, IL-1β and IL-6) at the early stage (8 days) but increased anti-inflammatory mediators (IL-4 and IL-10) at the late stage (16 days). PA-MSHA significantly up-regulated the mRNA expression of TLR4 at 8 and 16 days. After PA-MSHA pretreatment, CLP had no marked effect on the levels of most inflammatory factors. To explore potential protective mechanisms of PA-MSHA against CLP, we examined the effect of PA-MSHA on murine macrophage-like RAW264.7 cells and found that PA-MSHA induced endotoxin tolerance. In conclusion, this study suggested that precisely controlling the dosage and time of PA-MSHA administration can effectively increase the rat survival rate post CLP, which may be mediated through regulating inflammatory mediators and inducing endotoxin tolerance. PMID:24055021
76 FR 28096 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Training...
... safety training at the mine; a list of MSHA-approved instructors with whom the operator proposes to make... information, see the related notice published in the Federal Register on December 17, 2011 (75 FR 79030...) is submitting the Mine Safety and Health Administration (MSHA) sponsored information...
78 FR 79008 - Proposed Information Collection; Application for Waiver of Surface Sanitary Facilities...
... [MSHA- 2013-0038]. Regular Mail: Send comments to MSHA, Office of Standards, Regulations, and Variances... Standards, Regulations, and Variances, MSHA, at MSHA.information.collections@dol.gov (email);...
MSHA review of silicosis and dust control in mining
Thaxton, R.
Silicosis has become a forgotten disease. Many miners, when told of the risks of silicosis, indicate that they have never heard of the disease. A 1992 National Institute for Occupational Safety and Health (NIOSH) ALERT, however, pointed out that drilling in rock is hazardous to miners due to exposure to excessive amounts of silica-containing dust. Recent Mine Safety and Health Administration (MSHA) and NIOSH surveys also indicate that silicosis continues to be a significant health risk faced by miners. A joint field study conducted by NIOSH and MSHA in the Johnstown, Pennsylvania area found 8 cases of silicosis among 150 surveyed surface coal miners. Additional x-ray surveillance studies found 6 cases of disease among 234 current and former surface coal miners in the Poteau, Oklahoma area and 3 cases among 66 surface coal miners in the northern West Virginia area. These studies cannot be used to determine quantitative risk, or prevalence of the disease. They do, however, indicate the unacceptable reality that coal miners continue to develop silicosis. Surface miners are not the only miners potentially exposed to levels of silica-containing dust that may lead to development of silicosis. NIOSH and MSHA have received reports of disease among underground coal miners. Several of these cases involve coal miners under age 50. The focus of this presentation is to highlight the specific initiatives undertaken by MSHA`s Coal Mine Safety and Health to address this health hazard.
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Material required for MSHA records. 23.10... MSHA records. In order that MSHA may know exactly what it has tested and approved, it keeps detailed... the manufacturer must submit to MSHA before the approval is granted, to show the details of the...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Material required for MSHA records. 20.11... Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved... drawings which the manufacturer must submit to MSHA before approval is granted, to show the details of...
78 FR 9940 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Surface...
...; Surface Coal Mine--Daily Inspection, Certified Person, Inspection Report ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Surface Coal Mine--Daily Inspection, Certified...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Material required for MSHA records. 22.8..., EVALUATION, AND APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.8 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, it keeps detailed...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Material required for MSHA records. 22.8..., EVALUATION, AND APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.8 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, it keeps detailed...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Material required for MSHA records. 23.10..., EVALUATION, AND APPROVAL OF MINING PRODUCTS TELEPHONES AND SIGNALING DEVICES § 23.10 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, it keeps...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Material required for MSHA records. 19.10..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.10 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, detailed records are kept...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Material required for MSHA records. 19.10..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.10 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, detailed records are kept...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Material required for MSHA records. 23.10..., EVALUATION, AND APPROVAL OF MINING PRODUCTS TELEPHONES AND SIGNALING DEVICES § 23.10 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, it keeps...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Material required for MSHA records. 19.10..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.10 Material required for MSHA records. In order that MSHA may know exactly what it has tested and approved, detailed records are kept...
30 CFR 15.9 - Disclosure of information.
... performance submitted to MSHA by the applicant shall be considered proprietary information. (b) MSHA will... explosive units and shall give the applicant an opportunity to provide MSHA with a statement of its...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Criteria-MSHA Form 7000-1, Section B. 50.20-5 Section 50.20-5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR ACCIDENTS... extinguished within 30 minutes of discovery; Code 07—An unplanned ignition of a blasting agent or an...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Criteria-MSHA Form 7000-1, Section B. 50.20-5 Section 50.20-5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR ACCIDENTS... extinguished within 30 minutes of discovery; Code 07—An unplanned ignition of a blasting agent or an...
... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Criteria-MSHA Form 7000-1, Section B. 50.20-5 Section 50.20-5 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES,...
... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Proposed quality control plans; approval by MSHA. 28.32 Section 28.32 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...
... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Proposed quality control plans; approval by MSHA. 28.32 Section 28.32 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...
The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.
Wang, Changming; Hu, Zunqi; Zhu, Zhenxin; Zhang, Xin; Wei, Ziran; Zhang, Yu; Hu, Dali; Cai, Qingping
Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice. PMID:26662800
A critique of MSHA procedures for determination of permissible respirable coal mine dust containing free silica.
Corn, M; Breysse, P; Hall, T; Chen, G; Risby, T; Swift, D L
The literature in selected technical subject areas related to the Mine Safety and Health Administration's (MSHA) respirable mine dust control policy was critically reviewed. Specific topics included: (1) the technical aspects of respirable dust sampling, (2) the development of a sampling strategy and (3) currently used analytical techniques for free silica content of respirable coal mine dust. The 2.0 Lpm MSHA respirable dust sampling flow rate does not conform with published results which indicate that to simulate existing pulmonary particle deposition models, the sampling flow rate should range from 1.4 to 1.7 Lpm. MSHA's sampling strategy focuses on controlling respirable coal mine dust with both area and personal samples of workers in selected occupations or activities. Many uncertainties are encountered as area samples are used to estimate personal exposures. Although all of the analytical methods for crystalline free silica are sufficiently sensitive to be able to detect and quantitate free silica at environmentally significant concentrations, they are all plagued with similar difficulties. Analytical standards representing the various forms of silica are not available. Available analytical methods do not differentiate among polymorphs of silica. Recommendations are presented to resolve identified problem areas. PMID:2992262
76 FR 11282 - Agency Information Collection Activities; Submission for OMB Review; Comment Request...
...; Qualification/Certification Program Request for Mine Safety and Health Administration Individual Identification... Health Administration (MSHA), Office of Management and Budget, Room 10235, Washington, DC 20503... information, see the related notice published in the Federal Register on December 17, 2010 (75 FR...
Critique of MSHA procedures for determination of permissible respirable coal mine dust containing free silica
Selected subject areas related to the US Mine Safety and Health Administration respirable mine dust control policy are reviewed. These are: respirable dust sampling; sampling strategy; analytical techniques for free silica content. MSHA's sampling strategy focusses on controlling respirable coal mine dust with both area and personal samples of workers in selected activities. Many uncertainties are encountered as area samples are used to estimate personal exposures. Although all of the analytical methods for crystalline free silica are sufficiently sensitive to detect and quantify free silica at environmentally significant concentrations, all have similar difficulties. Recommendations are made for the resolution of identified problem areas.
76 FR 27355 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Mine...
... Register on January 5, 2011 (76 FR 589). Interested parties are encouraged to send comments to the OMB...; Mine Accident, Injury & Illness Report and Quarterly Mine Employment and Coal Production Report ACTION... Administration (MSHA) sponsored information collection request (ICR) titled, ``Mine Accident, Injury &...
75 FR 79417 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Diesel...
...The Department of Labor (DOL) hereby announces the submission of the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Diesel Particulate Matter Exposure of Underground Coal Miners,'' to the Office of Management and Budget (OMB) for review and approval for continued use in accordance with the Paperwork Reduction Act of 1995 (Pub. L. 104-13,......
76 FR 35473 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Sealing of...
... Register on February 17, 2011 (76 FR 9375). Interested parties are encouraged to send comments to the OMB...; Sealing of Abandoned Areas ACTION: Notice. SUMMARY: The Department of Labor (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled,...
77 FR 47438 - Agency Information Collection Activities; Submission for OMB Review; Comment Request...
...The Department of Labor (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Notification of Methane Detected in Underground Metal and Nonmetal Mine Atmospheres,'' to the Office of Management and Budget (OMB) for review and approval for continued use in accordance with the Paperwork Reduction Act (PRA) of 1995 (44 U.S.C.......
77 FR 35058 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Pilot...
...The Department of Labor (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored new information collection request (ICR) titled, ``Pilot Surveys of Employee Voice in the Coal Mining Industry,'' to the Office of Management and Budget (OMB) for review and approval for use in accordance with the Paperwork Reduction Act (PRA) of 1995 (44 U.S.C. 3501 et...
78 FR 70578 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Ventilation...
...The Department of Labor (DOL) is submitting the Mine Safety and Health Administration (MSHA) sponsored information collection request (ICR) titled, ``Ventilation Plan and Main Fan Maintenance Record,'' to the Office of Management and Budget (OMB) for review and approval for continued use, without change, in accordance with the Paperwork Reduction Act of 1995 (PRA), 44 U.S.C. 3501 et...
Yorio, Patrick L; Willmer, Dana R; Haight, Joel M
Since the late 1980s, the U.S. Department of Labor has considered regulating a systems approach to occupational health and safety management. Recently, a health and safety management systems (HSMS) standard has returned to the regulatory agenda of both the Occupational Safety and Health Administration (OSHA) and the Mine Safety and Health Administration (MSHA). Because a mandated standard has implications for both industry and regulating bodies alike, it is imperative to gain a greater understanding of the potential effects that an HSMS regulatory approach can have on establishment-level injuries and illnesses. Through the lens of MSHA's regulatory framework, we first explore how current enforcement activities align with HSMS elements. Using MSHA data for the years 2003-2010, we then analyze the relationship between various types of enforcement activities (e.g., total number of citations, total penalty amount, and HSMS-aligned citations) and mine reportable injuries. Our findings show that the reduction in mine reportable injuries predicted by increases in MSHA enforcement ranges from negligible to 18%. The results suggest that the type and focus of the enforcement activity may be more important for accident reduction than the total number of citations issued and the associated penalty amount. PMID:24471699
30 CFR 50.20-4 - Criteria-MSHA Form 7000-1, Section A.
..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-4 Criteria—MSHA Form 7000-1, Section A. (a) MSHA I.D. number. Enter...
An Information System for an Educational Administrator.
The Management Systems Series consists of documents of interest to persons concerned with the management of public resources. Operation PEP (Prepare Educational Planners), which called for a three-day session of instruction on Executive (Management Information Systems) was documented in detail as part of this series. This portion attempts to…
The MSHA pilus of Vibrio parahaemolyticus has lectin functionality and enables TTSS-mediated pathogenicity.
O'Boyle, Nicky; Houeix, Benoit; Kilcoyne, Michelle; Joshi, Lokesh; Boyd, Aoife
Vibrio parahaemolyticus is a seafood-borne pathogen which causes acute inflammatory gastroenteritis--a process which is mediated by the translocation of type three secretion system effector proteins. The molecular interactions governing colonization of the intestinal epithelium by this pathogen remain poorly understood. The mannose-sensitive haemagglutinin (MSHA) pilus was identified in this study as a significant factor in bacterial-host cell adherence and subsequent pathogenesis towards Caco-2 human intestinal epithelial cells. Deletion of essential components of the MSHA pilus resulted in a 60% decrease in adherence and a similar reduction in bacterial uptake by human intestinal cells. The diminished adherence of MSHA mutants correlated with significant decreases in V. parahaemolyticus-induced Caco-2 cell lysis, cell rounding and IL-8 secretion. Glycan array comparison between the V. parahaemolyticus wild type and MSHA deficient mutants identified lectin functionality for the MSHA pilus with specificity towards the fucosylated blood group oligosaccharide antigens Lewis A and X and blood groups A and B. The MSHA pilus also exhibited high affinity for the structurally related asialo-GM1 ganglioside, lacto-N-fucopentaose I and lacto-N-difucohexaose I. We hypothesize that these glycans act as receptors for the MSHA pilus in the gastrointestinal tract, thereby facilitating efficient colonization of the intestinal epithelium by V. parahaemolyticus. PMID:23981476
Energy Information Administration New Releases, July--August 1990
Jacobus, P.; Springer, I.
... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT... protection provided by the fuse for which an approval is sought. (b) If MSHA determines that the...
Hou, Jue; Liu, Yong; Liu, Ying; Shao, Yiming
The mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) has been shown to trigger naïve immune responses through the activation of monocytes, macrophages, natural killer cells (NK cells) and antigen presenting cells (APCs). Based on the hypothesis that PA-MSHA activates natural immunity through the Toll-like receptor (TLR) pathway, we scanned several critical TLR pathway molecules in mouse splenocytes using high-throughput real-time QRT-PCR and co-stimulatory molecule in bone marrow-derived dendritic cells (BMDCs) following in vitro stimulation by PA-MSHA. PA-MSHA enabled activation of the TLR pathway mediated by NF-κB and JNK signaling in splenocytes, and the co-stimulatory molecule CD86 was up-regulated in BMDCs. We then assessed the adjuvant effect of PA-MSHA for HIV-1 DNA vaccines. In comparison to DNA inoculation alone, co-inoculation with low dosage of PA-MSHA enhanced specific immunoreactivity against HIV-1 Env in both cellular and humoral responses, and promoted antibody avidity maturation. However, high doses of adjuvant resulted in an immunosuppressive effect; a two- or three-inoculation regimen yielded low antibody responses and the two-inoculation regimen exhibited only a slight cellular immunity response. To our knowledge, this is the first report demonstrating the utility of PA-MSHA as an adjuvant to a DNA vaccine. Further research is needed to investigate the exact mechanisms through which PA-MSHA achieves its adjuvant effects on innate immune responses, especially on dendritic cells. PMID:23077664
Liu, Xiang-Feng; Wang, Li; Qu, Yi; Zhong, De-Wu; Miao, Xiong-Ying; Yao, Hong-Liang
Sepsis is defined as a complex clinical syndrome caused by a serious infection followed by an amplified and deregulated inflammatory response. The complex syndrome is associated with a high rate of morbidity and mortality, despite substantial clinical advances. A vaccine derived from the outer membrane proteins of the Gram-negative bacteria Pseudomonas aeruginosa (PA-MSHA) has been demonstrated to exhibit immune modulatory properties. In the present study, the effect of the PA-MSHA vaccine on the inflammatory response induced by serum from septic patients in peripheral blood mononuclear cells was determined. It was observed that PA-MSHA pretreatment inhibits the production of septic serum-induced tumor necrosis factor-α. In addition, PA-MSHA treatment increases interleukin-10 levels and promotes the generation of CD4+CD25+Foxp3+ T cells. Thus, the results of the current study provide mechanistic insight relevant to the potential application of PA-MSHA in the treatment of sepsis. PMID:23440442
Energy Information Administration (EIA) new releases, January--February 1994
This report is the Jan-Feb 1994 issue of the Energy Information Administration (EIA) New Releases publication. Highlighted articles include: efficiency gains slow growth in U.S. energy demand, dependency on oil imports continues to climb; new EIA report details status of U.S. coal industry; EIA assesses residential vehicle fuel consumption in the U.S.; EIA plans new survey on alternative-fuel vehicles.
Calibration and maintenance procedures for coal mine respirable dust samplers. Informational report
Tomb, T.F.; Parobeck, P.S.
The Federal Mine Safety and Health Act of 1977 requires that the average concentration of respirable coal mine dust be measured with a device approved by the Secretary of Labor and the Secretary of Health and Human Services. The information report describes the standard procedures used by the Mine Safety and Health Administration (MSHA) for calibration of current approved personal samplers and associated equipment and for maintenance of this equipment.
Saville, Renée M; Dieckmann, Nele; Spormann, Alfred M
Type IV pili and a putative EPS biosynthetic gene cluster (mxdABCD) have been implicated previously in biofilm formation in Shewanella oneidensis MR-1. Here, we report that the mannose-sensitive hemagglutinin (MSHA) pilus mediates a reversible, d-mannose-sensitive association of cells to the substratum surface or to other cells that is critical within the first 5 microm of the biofilm from the substratum. The presence of the MSHA pilus alone is insufficient to confer biofilm-forming capacity; its activity, as mediated by the putative pilus retraction motor protein, PilT, is also required. Deletion of pilD, encoding the type IV pili prepilin peptidase, revealed that additional PilD substrate(s) may be involved in biofilm formation beyond the major structural pilin of the MSHA pilus. We also present data showing that the MSHA pilus and mxd genes encode for a complementary set of molecular machineries that constitute the dominant mechanisms enabling biofilm formation in this microorganism under hydrodynamic conditions. PMID:20487019
30 CFR 50.20-7 - Criteria-MSHA Form 7000-1, Section D.
..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-7 Criteria—MSHA Form 7000-1, Section D. This section requires...
..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-5 Criteria—MSHA Form 7000-1, Section B. (a) This section shall be...
Implementation of an advanced clinical and administrative hospital information system.
Vegoda, P R; Dyro, J F
Over the last six years since University Hospital opened, the University Hospital Information System (UHIS) has continued to evolve to what is today an advanced administrative and clinical information system. At University Hospital UHIS is the way of conducting business. A wide range of patient care applications are operational including Patient Registration, ADT for Inpatient/Outpatient/Emergency Room visits, Advanced Order Entry/Result Reporting, Medical Records, Lab Automated Data Acquisition/Quality Control, Pharmacy, Radiology, Dietary, Respiratory Therapy, ECG, EEG, Cardiology, Physical/Occupational Therapy and Nursing. These systems and numerous financial systems have been installed in a highly tuned, efficient computer system. All applications are real-time, on-line, and data base oriented. Each system is provided with multiple data security levels, forward file recovery, and dynamic transaction backout of in-flight tasks. Sensitive medical information is safeguarded by job function passwords, identification codes, need-to-know master screens and terminal keylocks. University Hospital has an IBM 3083 CPU with five 3380 disk drives, four dual density tape drives, and a 3705 network controller. The network of 300 terminals and 100 printers is connected to the computer center by an RF broadband cable. The software is configured around the IBM/MVS operating system using CICS as the telecommunication monitor, IMS as the data base management system and PCS/ADS as the application enabling tool. The most extensive clinical system added to UHIS is the Physiological Monitoring/Patient Data Management System with serves 92 critical care beds. In keeping with the Hospital's philosophy of integrated computing, the PMS/PDMS with its network of minicomputers was linked to the UHIS system. In a pilot program, remote access to UHIS through the IBM personal computer has been implemented in several physician offices in the local community, further extending the communications
Noda, Yasuha; Sakata, Yoshifumi; Kubota, Masakazu; Uemura, Kengo; Kihara, Takeshi; Kimura, Toru; Ino, Masashi; Tsuji, Teruyuki; Hayashi, Michiyuki; Kinoshita, Ayae
Drug adherence is central to the treatment of dementia, which might reduce compliance due to memory loss, particularly among home-based patients with dementia. In order to improve drug adherence, we suggest the efficient and effective supervised administration by use of information communication technology(ICT). ICT makes face-to-face real-time communication possible, and it also enables picture sharing. Therefore, it might be useful to apply ICT to controlling and supervising medication for patients with dementia to improve drug adherence. Accordingly, we enrolled patients who were supposed to take a newly prescribed anti-dementia patch containing the choline esterase inhibitor rivastigmine(Rivastach®)and investigated the effect of ICT-based intervention for drug adherence, emotional change, and cognitive change, utilizing Skype, a free communication software program. Scheduled Skype interventions increased drug adherence ratio, levels of subjective satisfaction, and instrumental activities of daily living(IADL). Furthermore, we can provide patients and their caregivers with a feeling of safety through regular bidirectional communication, as patients can easily consult medical staff regarding the adverse effects of newly prescribed drugs. Instead of frequent visits to their primary physicians, ICT-based communications can be used as a substitute for supervision of medication, given the availability of the telecommunication system. By directly connecting the medical institution to the home, we expect that this ICT-based system will expand into the geriatric care field, including the care of elderly individuals living alone. PMID:25595075
Vetting,M.; Frantom, P.; Blanchard, J.
The glycosyltransferase termed MshA catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to 1-l-myo-inositol-1-phosphate in the first committed step of mycothiol biosynthesis. The structure of MshA from Corynebacterium glutamicum was determined both in the absence of substrates and in a complex with UDP and 1-l-myo-inositol-1-phosphate. MshA belongs to the GT-B structural family whose members have a two-domain structure with both domains exhibiting a Rossman-type fold. Binding of the donor sugar to the C-terminal domain produces a 97 rotational reorientation of the N-terminal domain relative to the C-terminal domain, clamping down on UDP and generating the binding site for 1-l-myo-inositol-1-phosphate. The structure highlights the residues important in binding of UDP-N-acetylglucosamine and 1-l-myo-inositol-1-phosphate. Molecular models of the ternary complex suggest a mechanism in which the {beta}-phosphate of the substrate, UDP-N-acetylglucosamine, promotes the nucleophilic attack of the 3-hydroxyl group of 1-l-myo-inositol-1-phosphate while at the same time promoting the cleavage of the sugar nucleotide bond.
Multiparadigm Perspectives of Administration: Informing Theory and Practice.
A multiparadigm perspective of educational administration is offered in this paper, which offers a conceptualization of administration as a heuristic device for considering multiple views of education. The first section describes the work of Sirotnik and Oakes (1986) whose "critical inquiry" multipardigm approach comprises three paradigms:…
Liu, Z-B; Hou, Y-F; Zhu, J; Hu, D-L; Jin, W; Ou, Z-L; Di, G-H; Wu, J; Shen, Z-Z; Shao, Z-M
To identify more therapeutic targets and clarify the detailed mechanisms of Pseudomonas aeruginosa-mannose-sensitive hemagglutinin (PA-MSHA) on breast cancer cells both in vitro and in vivo. PA-MSHA was administered to epidermal growth factor receptor (EGFR)-positive human breast cancer cell lines MDA-MB-231HM and MDA-MB-468 in vitro and to mice bearing tumor xenografts. The mannose cocultured test was used to detect the effect of mannose on PA-MSHA-induced cell proliferation, cell cycle arrest, apoptosis, and EGFR pathway signaling. We found that cells stimulated with PA-MSHA exhibited a downregulation of EGFR signaling. The addition of mannose partially inhibited the PA-MSHA-stimulated cell anti-proliferative effect, cell apoptosis, cell cycle arrest, activation of apoptosis-associated caspases, and even downregulation of the EGFR signaling pathway. In vivo, PA-MSHA treatment significantly suppressed mammary tumorigenesis in xenografts in mice and decreased lung metastasis in MDA-MB-231HM cell-transplanted mice. Tumor sample analyses confirmed inhibition of the EGFR pathway in the PA-MSHA-treated mice. In conclusion, this study showed that the involvement of the mannose-mediated EGFR pathway has a critical function in the preclinical rationale for the development of PA-MSHA for the treatment of human breast cancer. It also suggests the potentially beneficial use of PA-MSHA in adjuvant therapy for breast tumors with EGFR overexpression. PMID:20228837
30 CFR 250.228 - What administrative information must accompany the EP?
... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of Exploration Plans (ep) § 250.228 What administrative information must accompany the EP?...
Reinventing MSHA
Nichols, M.W. Jr.
Much has been accomplished in the area of mine safety and health since the enactment of the Federal Coal Mine Health and Safety Act of 1969 and its sister legislation, the Federal Mine Safety and Health Act of 1977. Since the enactment of these two pieces of landmark legislation, the mining community has experienced a continual downward trend in fatalities and serious lost time injuries. Mining technology has developed equipment which permits the safer extraction of coal and other minerals. Mine personnel have developed and implemented innovative mining methodologies which have resulted in safer and more efficient mining cycles. Today, the industry mines approximately one billion tons of coal and has achieved a health and safety record which is the envy of the industrialized nations. In looking back over the years, one can readily determine that the mining community has much to be proud about. However, not withstanding these success stories, this mining community, including labor, management, academia and the regulatory agencies, must guard against becoming complacent and satisfied with these accomplishments.
Liu, Ying-Bao; Chen, Can; Chaudhry, Muhammad Tausif; Si, Mei-Ru; Zhang, Lei; Wang, Yao; Shen, Xi-Hui
Over-expression of the gene, mshA, coding for mycothiol glycosyl transferase improved the robustness of Corynebacterium glutamicum to various stresses. Intracellular mycothiol (MSH) content was increased by 114 % in WT(pXMJ19-mshA) compared to WT(pXMJ19). Survival rates increased by 44, 39, 90, 77, 131, 87, 52, 47, 57, 85 and 33 % as compared to WT(pXMJ19) under stress by H2O2 (40 mM), methylglyoxal (5.8 mM), erythromycin (0.08 mg ml(-1)), streptomycin (0.005 mg ml(-1)), Cd(2+) (0.01 mM), Mn(2+) (2 mM), formic acid (0.05 %), acetic acid (0.15 %), levulinic acid (0.25 %), furfural (7.2 mM), and ethanol (10 % v/v), respectively. Increased MSH content also decreased the concentration of reactive oxygen species in the presence of the above stresses. Our results may open a new avenue for enhancing robustness of industrial bacteria for production of commodity chemicals. PMID:24737070
Zhang, Yunyan; Wang, Hongtao; Li, Youqiang; Chen, Ke; Ye, Jinmei; Liao, Xin; Chen, Yiyang; Ran, Wei
Pseudomonas aeruginosa mannose sensitive hamemagglutination strain (PA-MSHA) is a kind of peritrichous P. aeruginosa strain with MSHA fimbriae and has been shown to activate kinds of immunocytes. Dendritic cells (DCs) are specialized antigen-presenting cells required for the stimulating and priming CD4(+) T cells toward the T helper cell type 1 (Th1), Th2 and other different phenotypes. PA-MSHA effecting on Th1 remains an important missing link. Here we demonstrated that PA-MSHA augmented monocytes derived-dendritic cells (Mo-DCs) expression of HLA-DR, co-stimulatory and adhesion molecules, and induced Th1-promoting interleukin-12 and tumor necrosis factor α secretion, in addition, PA-MSHA treated Mo-DCs displayed lesser endocytic capacity. Furthermore, in mixed lymphocyte reactions, allostimulatory capacity of Mo-DCs was enhanced by PA-MSHA, CD4(+) T cells stimulated by PA-MSHA -activated Mo-DCs showed a Th1-polarized cytokine production, increasing secretion of IFN-γ and decreasing secretion of IL-10 and IL-4. Our findings identified PA-MSHA as an important exogenous factor that induced DCs maturation toward a Th1-promoting phenotype. PMID:25320417
Administrative Information Systems: The 1985 Profile and Five-Year Trends. CAUSE Monograph Series.
Thomas, Charles R.; van Hoesen, Dana S.
Information is presented about the administrative computing activities of colleges and universities belonging to CAUSE (the professional association for computing and information technology in higher education). Profiles and trends are provided based on 1985 Member Institution Profile Surveys conducted in 1980, 1983, and 1985. A total of 350…
Administrative Aspects of Third World Library Development: The Five "Pillars" of Sustainable Information Transfer.
Emerson, Susan Vince; And Others
Third World libraries, as a rule, receive information technology, technical assistance, and training as part of international development projects. Library improvements and their intended objective, information transfer, are more effective and lasting if key administrative and policy issues are addressed by the projects. Critical success factors…
U.S. Government Information Policy: The Coming of a New Administration.
Discussion of possible information policy initiatives of the Clinton administration focuses on the issues addressed by a 1992 draft document which revises the Office of Management and Budget's Circular A-130, "The Management of Federal Information Resources." Recommended revisions for the circular are listed. (seven references) (EA)
Debugging the Conversion Process: Lessons from an Administrative Information System Conversion.
Hibbler, Fritz; Mitchell, Linda
The process of reengineering the administrative information system at the University of Idaho required careful planning, development of a set of philosophies, and several strategies for ensuring success. The latter included a humorous symbol (a jitter bug) to express concern, improved institutional communications, and a focus on logistical issues.…
The study surveyed 96 Bruneian primary schools administrators (principals) in using the Information and Communication Technologies (ICT). Out of the five subscales used to assess the ICT usage, only two: curriculum integration and need assessment were found to be significant towards the use of the ICT. The results further indicate that majority of…