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Patent US6264701 - Device and methods for in vivo culturing of diverse tissue cells - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsAn anatomically specific, bioresorbable, implant device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment of using the implant device for facilitating the healing of a human joint lesion includes a cartilage region invested with an alginate...http://www.google.com/patents/US6264701?utm_source=gb-gplus-sharePatent US6264701 - Device and methods for in vivo culturing of diverse tissue cellsAdvanced Patent SearchPublication numberUS6264701 B1Publication typeGrantApplication numberUS 09/206,604Publication dateJul 24, 2001Filing dateDec 7, 1998Priority dateMay 13, 1994Fee statusPaidAlso published asDE69536051D1, US5981825Publication number09206604, 206604, US 6264701 B1, US 6264701B1, US-B1-6264701, US6264701 B1, US6264701B1InventorsJohn H. BrekkeOriginal AssigneeKensey Nash CorporationExport CitationBiBTeX, EndNote, RefManPatent Citations (81), Non-Patent Citations (73), Referenced by (53), Classifications (16), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetDevice and methods for in vivo culturing of diverse tissue cells
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS2465357Aug 14, 1944Mar 29, 1949Upjohn CoTherapeutic sponge and method of makingUS2610625Oct 14, 1947Sep 16, 1952Armour & CoSurgical sponge and the preparation thereofUS2621145Aug 17, 1949Dec 9, 1952Sano Machteld EBone mat compositionsUS2703316Jun 5, 1951Mar 1, 1955Du PontPolymers of high melting lactideUS2758987Jun 5, 1952Aug 14, 1956Du PontOptically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acidUS3463158Jan 9, 1967Aug 26, 1969American Cyanamid CoPolyglycolic acid prosthetic devicesUS3491760Jul 6, 1966Jan 27, 1970Braun Intern Gmbh BWound coveringsUS3636956May 13, 1970Jan 25, 1972Ethicon IncPolylactide suturesUS3688317Aug 25, 1970Sep 5, 1972Sutures IncVascular prostheticUS3739773Jun 28, 1971Jun 19, 1973American Cyanamid CoPolyglycolic acid prosthetic devicesUS3902497Mar 25, 1974Sep 2, 1975American Cyanamid CoBody absorbable sponge and method of makingUS3937223Apr 19, 1974Feb 10, 1976American Cyanamid CompanyCompacted surgical hemostatic feltUS4164560Jan 5, 1977Aug 14, 1979Folkman Moses JSystems for the controlled release of macromoleculesUS4181983Aug 29, 1977Jan 8, 1980Kulkarni R KAssimilable hydrophilic prosthesisUS4186448Nov 21, 1977Feb 5, 1980Brekke John HDevice and method for treating and healing a newly created bone voidUS4279249Oct 17, 1979Jul 21, 1981Agence Nationale De Valorisation De La Recherche (Anvar)New prosthesis parts, their preparation and their applicationUS4357312Jul 16, 1981Nov 2, 1982The Children's Hospital Medical CenterMethod of making prolonged release bodyUS4419340Nov 20, 1980Dec 6, 1983University Of DelawareControlled release of anticancer agents from biodegradable polymersUS4442655Jun 25, 1982Apr 17, 1984Serapharm Michael StroetmannFibrinogen-containing dry preparation, manufacture and use thereofUS4505266Apr 17, 1984Mar 19, 1985Massachusetts Institute Of TechnologyMethod of using a fibrous latticeUS4553272Feb 26, 1981Nov 19, 1985University Of PittsburghRegeneration of living tissues by growth of isolated cells in porous implant and product thereofUS4563350Oct 24, 1984Jan 7, 1986Collagen CorporationInductive collagen based bone repair preparationsUS4563489Feb 10, 1984Jan 7, 1986University Of CaliforniaBiodegradable organic polymer delivery system for bone morphogenetic proteinUS4578384Feb 15, 1984Mar 25, 1986The United States Of America As Represented By The Secretary Of The ArmyPolylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissueUS4596574May 14, 1984Jun 24, 1986The Regents Of The University Of CaliforniaBiodegradable porous ceramic delivery system for bone morphogenetic proteinUS4608199Mar 20, 1984Aug 26, 1986Arnold CaplanBone protein purification processUS4609551Mar 20, 1984Sep 2, 1986Arnold CaplanProcess of and material for stimulating growth of cartilage and bony tissue at anatomical sitesUS4620327Jul 5, 1984Nov 4, 1986Caplan Arnold IProcess of adapting soluble bone protein for use in stimulating osteoinductionUS4636526Feb 19, 1985Jan 13, 1987The Dow Chemical CompanyComposites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prostheticsUS4642120Mar 21, 1984Feb 10, 1987Ramot University Authority For Applied Research And Industrial Development Ltd.Repair of cartilage and bonesUS4713076Apr 17, 1985Dec 15, 1987Klaus DraenertCoating composition and anchorage component for surgical implantsUS4749585Apr 11, 1986Jun 7, 1988University Of Medicine And Dentistry Of New JerseyAntibiotic bonded prosthesis and process for producing sameUS4752294Feb 26, 1985Jun 21, 1988Dan LundgrenElement for controlled growth into surgically intervened areasUS4846835Jun 15, 1987Jul 11, 1989Grande Daniel ATechnique for healing lesions in cartilageUS4938763Oct 3, 1988Jul 3, 1990Dunn Richard LBiodegradable in-situ forming implants and methods of producing the sameUS4962091May 23, 1986Oct 9, 1990Syntex (U.S.A.) Inc.Controlled release of macromolecular polypeptidesUS4964868Aug 27, 1987Oct 23, 1990Harrington Arthritis Research CenterKnee prosthesisUS5041138Apr 17, 1989Aug 20, 1991Massachusetts Institute Of TechnologyNeomorphogenesis of cartilage in vivo from cell cultureUS5061281Dec 17, 1986Oct 29, 1991Allied-Signal Inc.Bioresorbable polymers and implantation devices thereofUS5077049Jul 24, 1989Dec 31, 1991Vipont Pharmaceutical, Inc.Biodegradable system for regenerating the periodontiumUS5078744Sep 22, 1989Jan 7, 1992Bio-Products, Inc.Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibersUS5133755Jun 21, 1990Jul 28, 1992Thm Biomedical, Inc.Method and apparatus for diodegradable, osteogenic, bone graft substitute deviceUS5152791Feb 18, 1992Oct 6, 1992Olympus Optical Co., Ltd.Prosthetic artificial bone having ceramic layers of different porosityUS5288496May 15, 1990Feb 22, 1994Stolle Research & Development CorporationGrowth promoters for animalsUS5294446Jan 2, 1992Mar 15, 1994Southwest Research InstituteComposition and method of promoting hard tissue healingUS5324519Oct 28, 1991Jun 28, 1994Atrix Laboratories, Inc.Biodegradable polymer compositionUS5326357Mar 18, 1992Jul 5, 1994Mount Sinai Hospital CorporationReconstituted cartridge tissueUS5356429 *Oct 13, 1992Oct 18, 1994Seare William J JrBody pocket maintenance prosthesisUS5366508Jul 7, 1992Nov 22, 1994Thm Biomedical, IncApparatus for biodegradable, osteogenic, bone graft substitute deviceUS5372821Dec 15, 1993Dec 13, 1994Purdue Research FoundationGraft for promoting autogenous tissue growthUS5376118Mar 26, 1993Dec 27, 1994United States Surgical CorporationSupport material for cell impregnationUS5425639May 3, 1994Jun 20, 1995Anders; IrvingDental implant with shock absorbent cushioned interfaceUS5447725 *Jun 11, 1993Sep 5, 1995The Procter & Gamble CompanyMethods for aiding periodontal tissue regenerationUS5478739Oct 23, 1992Dec 26, 1995Advanced Tissue Sciences, Inc.Three-dimensional stromal cell and tissue culture systemUS5512475Apr 6, 1995Apr 30, 1996Advanced Tissue Sciences, Inc.Three-dimensional skin cell and tissue culture systemUS5520923Sep 19, 1994May 28, 1996Genetics Institute, Inc.Formulations for delivery of osteogenic proteinsUS5569463Jun 7, 1995Oct 29, 1996Harbor Medical Devices, Inc.Medical device polymerUS5607474Sep 20, 1993Mar 4, 1997Board Of Regents, University Of Texas SystemMulti-phase bioerodible implant/carrier and method of manufacturing and using sameUS5616338Apr 19, 1991Apr 1, 1997Trustees Of Columbia University In The City Of New YorkInfection-resistant compositions, medical devices and surfaces and methods for preparing and using sameUS5645084Jun 7, 1995Jul 8, 1997Danek Medical, Inc.Method for spinal fusion without decorticationUS5665114Aug 12, 1994Sep 9, 1997Meadox Medicals, Inc.Tubular expanded polytetrafluoroethylene implantable prosthesesUS5736160Oct 28, 1994Apr 7, 1998Thm Biomedical, Inc.Process and device for treating and healing a bone voidUS5830493Sep 28, 1995Nov 3, 1998Yamanouchi Pharmaceutical Co., Ltd.Bone-forming graftCA1274179AApr 30, 1986Sep 18, 1990Massachusetts Inst TechnologyBioerodible articles useful as implants and prostheses having predictable degradation ratesDE3841397A1Dec 8, 1988Jun 21, 1990Melzer WolfgangPorous absorbable medicinal substance carrierEP0277678A1Jan 18, 1988Aug 10, 1988Stichting Science Park GroningenA graft suitable for treatment by reconstructive surgery and having tissue-specific porosity, and a process for making such graftEP0369034A1May 29, 1989May 23, 1990Sumitomo Cement Co. Ltd.Artificial bone structure for transplantation of boneEP0505634A1Apr 26, 1991Sep 30, 1992Kyocera CorporationA prosthesisEP0567391A1Apr 20, 1993Oct 27, 1993Bristol-Myers Squibb CompanyA biodegradable tgf-beta delivery system for bone regenerationGB2164024A Title not availableGB2175506A Title not availableJP63238867A Title not availableJPH0323864A Title not availableJPS63238867A Title not availableWO1986000533A1Jul 10, 1985Jan 30, 1986Rijksuniversiteit Te GroningenBone implantWO1988003785A1Nov 20, 1987Jun 2, 1988Vacanti Joseph PChimeric neomorphogenesis of organs by controlled cellular implantation using artificial matricesWO1990009783A1Feb 22, 1990Sep 7, 1990Massachusetts Institute Of TechnologyDelivery system for controlled release of bioactive factorsWO1990015586A2Jun 1, 1990Dec 27, 1990Massachusetts Institute Of TechnologyBioerodible polymers for drug delivery in boneWO1993015694A1Feb 12, 1993Aug 19, 1993Board Of Regents, The University Of Texas SystemMulti-phase bioerodible implant/carrier and method of manufacturing and using sameWO1993020859A1Apr 16, 1993Oct 28, 1993Board Of Regents Of The University Of WashingtonSustained release compositions for delivery of growth factorsWO1994009722A1Oct 20, 1993May 11, 1994Thm Biomedical, Inc.Method and device for reconstruction of articular cartilage* Cited by examinerNon-Patent CitationsReference1An evaluation of two configurations of tricalcium phosphate for treating craniotomies, J. Biomedical Materials Research, vol. 23, No. 1, Jan. 1989, pp 17-29.2Application of Porous Ceramics for the Attachment of Load Bearing Internal Orthopedic Applications, J.J. Klawitter et al., Bioceramics-Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 161-129 (1972).3Application of Porous Ceramics for the Attachment of Load Bearing Internal Orthopedic Applications, J.J. Klawitter et al., Bioceramics—Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 161-129 (1972).4Attachment and survival of perichondrocytes in a porous polylactic acid (PLA) matrix: an in vitro study, by C.R. Chu, A.Z. Monosov, R.D. Coutts, and D. Amiel, Thirteenth Southern Biomedical Engineering Conference, Apr. 16-17, 1994, University of the District of Columbia, Washington, D.C.5Beta-tricalcium Phosphate Delivery System for Bone Morphogenetic Protein, Marshall R. Urist et al., Clinical Orthopaedics and Related Research, No. 187, pp. 277-280 (1984).6Bioceramics-Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, R. Topazian et al., No. 2 (Part 2), pp. 311-332 (1972).7Bioceramics—Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, R. Topazian et al., No. 2 (Part 2), pp. 311-332 (1972).8Bioresorbability and Biocompatibility of Aliphatic Polyesters, M. Vert et al., Journal of Materials Science: Materials in Medicine 3, (C)1992 Chapman & Hall, pp. 432-446.9Bioresorbability and Biocompatibility of Aliphatic Polyesters, M. Vert et al., Journal of Materials Science: Materials in Medicine 3, �1992 Chapman & Hall, pp. 432-446.10Calcium Phosphate Ceramics as Hard Tissue Prosthetics, Michael Jarcho, PH.D., Clinical Orthopaedics and Related Research, No. 157, pp. 259-278 (1981).11Calvaria Repair in Monkeys Using Alloplastic-Alloimplants, The 13th Annual Meeting of the Society for Biomaterials, Jun. 2-6, 1987, New York, New York.12Cartilage resurfacing of the rabbit knee, E. Billings, Jr. et al., Acta Orthop Scand 1990; 61(3), pp. 201-206.13Compatibility of Porous Ceramics with Soft Tissue; Application to Tracheal Prosthesis, S.F. Hulbert et al., Bioceramics-Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, vol. 2, (Part 1), pp. 269-279 (1972).14Compatibility of Porous Ceramics with Soft Tissue; Application to Tracheal Prosthesis, S.F. Hulbert et al., Bioceramics—Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, vol. 2, (Part 1), pp. 269-279 (1972).15Compressive Characteristics of Freeze-Dried Agar and Alginate Gel, A. Nussinovitch et al., Biotechnol Prog, pp. 101-104 (1993).16Controlled Release of TGF-B, From a Biodegradable Matrix for Bone Regeneration, J.Biomater, Sci. Polymer Edn., vol. 5 No. 1/2, pp 49-63, 1993.17Culture and differentiation of chondrocytes entrapped in alginate gels, by M. Grandolfo, P. D'Andrea, S. Paoletti, M. Martina, G. Silvestrini, E. Bonucci, and F. Vittur, Calcif. Tissue Int., 52, pp 42-48, (1993).18Culture-Expanded Human Priosteal-Derived Cells Exhibit Osteochondral Potential In Vivo, H. Nakahara et al., and Journal of Orthopaedic Research, vol. 9, No. 4, 1991, pp. 465-476.19David H. Cormach, "Ham's Histology", Nineth Edition, (C) 1987, J.B. Lippincutt Company, pp. 325-326.20David H. Cormach, "Ham's Histology", Nineth Edition, � 1987, J.B. Lippincutt Company, pp. 325-326.21Development of Ceramic and Ceramic Composite Devices for Maxillofacial Applications, T.D. Driskell et al., Bioceramics-Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, No. 2 (Part 2), pp. 345-361 (1972).22Development of Ceramic and Ceramic Composite Devices for Maxillofacial Applications, T.D. Driskell et al., Bioceramics—Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, No. 2 (Part 2), pp. 345-361 (1972).23Developmental Role of Hyaluronate, Bryan P. Toole, Connective Tissue Research, vol. 10, pp. 93-100 (1982).24Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial, T.L. Seitz et al., Journal of Biomedical Materials Research, vol. 16, pp. 195-207 (1982).25Effect of freeze-dried poly-L-lactic acid discs mixed with bone morphogenetic protein on the healing of rat skull defects by T. Miki, K. Harada, Y. Imai, and S. Enomoto, J. Oral Maxillofac. Surg., 52, pp 387-391, (1994).26Effect of Surgical Trauma and Polylactate Cubes and Granules on the Incidence of Alveolar Osteitis in Madibular Third Molar Extraction Wounds, John Brekke et al, J. Canad Dent Assn, No. 4, pp. 315-319 (1986).27Effect of the Structure of Poly(Glycol Monomethacrylate) Gel on the Calcification of Implants, L. Sprinel et al., Calc. Tiss., Res. 13, pp. 63-72 (1973).28Evidence for the existence of hyaluronectin-binding proteins in the plasma membranes, Sanjay Gupta et al., FEBS 13470, vol. 336, pp. 511-515 (1993).29Expression and modulation of CD44 variant isoforms in humans, by C.R. Mackay, H-J. Terpe, R. Stauder, W.L. Marston, H. Stark and U. G�nthert, J. Cell Bio., 124 (1&2), pp 71-82, (Jan. 1994).30Growth factor responsiveness of perichondrial cells in monolayer and attached to polylactic acid carriers, M. Lotz et al., American College of Rheumatology, Nov. 17-21, 1991.31Guidor, The Bioresorbable Matrix Barrier, pp. 1-33 (1993).32Healing of Hyaluronic Acid-Enriched Wounds: Histological Observations, G. Abatangelo et al., Journal of Surgical Research 35, pp. 410-416 (1983).33Human Biochemistry, The C.V. Mosby Company, St. Louis, pp 440, 1982.34Human Bone Morphongenetic Protein, Marshall R. Urist et al., Proceedings of the Society for Experimental Biology and Medicine 173, pp. 194-199 (1983).35Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition, by K. Miyake, C.B. Underhill, J. Lesley, and P.W. Kincade, J. Exp. Med., 172, pp 69-75, (1990).36Identification of hyaluronic acid binding sites in the extracellular domain of CD44, by R.J. Peach, D. Hollenbaugh, I. Stamenkovic, and A. Aruffo, J. Cell Bio., 122 (1), pp 257-264 (Jul. 1993).37In vivo degradation of massive poly (a-hydroxy acids): validation of in vitro findings, M. Therin et al., Biomaterials vol. 13, No. 9, (C)1992 pp. 594-600.38In vivo degradation of massive poly (a-hydroxy acids): validation of in vitro findings, M. Therin et al., Biomaterials vol. 13, No. 9, �1992 pp. 594-600.39In Vivo Osteochondrogenic Potential of Cultured Cells Derived From the Periosteum, H. Nakahara et al., Clinical Orthopaedics, Oct. 1990, vol. 259, pp. 223-232.40Influence of matricial molecules on growth and differentiation of entrapped chondrocytes, by H. Ramdi, C. Legar, and M. Lievremont, Experi. Cell Res., 207, pp 449-454, (1993).41Influence of polylactic acid mesh on the incidence of localized osteitis, John H. Brekke et al., Oral Surg., vol. 56, No. 3, pp. 240-245 (1983).42Laminated three-dimensional biodegradable foams for use in tissue engineering, by A.G. Mikos, G. Sarakinos, S.M. Leite, J.P. Vacanti, and R. Langer, Biomat., 14 (5), pp 323-330, (1993).43Mechanisms of polymer degradation in implantable devices. 2. Poly(DL-lactic acid), S.A.M. Ali et al., Journal of Biomedical Materials Research, vol. 27, (C)1993 pp. 1409-1418.44Mechanisms of polymer degradation in implantable devices. 2. Poly(DL-lactic acid), S.A.M. Ali et al., Journal of Biomedical Materials Research, vol. 27, �1993 pp. 1409-1418.45Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers, by L.E. Freed, J.C. Marquis, A. Nohria, J. Emmanual, A.G. Mikos, and R. Langer, J. Biomed. Mat. Res., 27, pp 11-23, (1993).46New Insights on the Degradation of Bioresorbable Polymeric Devices Based on Lactic and Glycolic Acids, Vert et al., Clinical Materials 10, 1992 pp. 3-8.47Polylactic Acid Surgical Dressing Material Postoperative Therapy for Dental Extraction Wounds, J Canad. Dent. Assn. No. 7, 1986, pp 599-602.48Polymers, R. Langer, Bone Symposium '91, Oregon Health Sciences University, Portland, Oregon, Jul. 17-20, 1991, pp. 367-373.49Porous polymer implants for repair of full-thickness defects of articular cartilage: an experimental study in rabbit and dog, by J. Klompmaker, H.W.B. Jansen, R.P.H. Veth, H.K.L. Nielsen, J.H. de Groot, and A.J. Pennings, Biomat., 13 (9), pp 625-634, (1992).50Potential of Adult Human Perichondrium to Form Hyalin Cartilage In Vitro, S.K. Bulstra et al., Journal of Orthopaedic Research, vol. 8, No. 3, 1990, pp. 328-335.51Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation, by A.G. Mikos, Y. Bao, L.G. Cima, D.E. Ingber, J.P. Vacanti, and R. Langer, J. Biomed. Mat. Res., 27, pp 183-189, (1993).52Rabbit articular chondrocytes in alginate gel: characterisation of immobilized preparations and potential applications, by C. Tamponnet, H. Ramdi, J-B. Guyot, and M. Lievremont, Appl. Microbiol. Biotechnol., 37, pp 311-315, (1992).53Reconstruction of rabbit knee articular defects with a polylactic acid matrix and periosteal grafts, R.D. Coutts et al., Combined Meeting/Orthopaedic Research Societies, Oct. 21-23, 1991.54Reconstruction of rabbit knee articular defects with a polylactic acid matrix, R.D. Coutts et al., Orthopaedic Research Society, Feb. 5-8, 1990.55Repair of Articular Surfaces by Allografts of Articular and Growth-Plate Cartilage, by J.E. Aston et al., The Journal of Bone and Joint Surgery, vol. 68-B, No. 1, Jan. 1986.56Repair of Rabbit Articular Surfaces with Allograft Chondrocytes Embedded in Collagen Gel, by S. Wakitani et al., The Journal of Bone and Joint Surgery, vol. 71-B, No. 1, Jan. 1989, pp. 74-86.57Resorbable Ceramic Implants, G.A. Graves et al., Bioceramics-Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 91-115 (1972).58Resorbable Ceramic Implants, G.A. Graves et al., Bioceramics—Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 91-115 (1972).59Rib Periocondrial Autografts in Full-Thickness Articular Cartilage Defects in Rabbits, R.D. Coutts et al., Clinical Orthopaedics, Feb. 1992, vol. 275, pp. 263-273.60Sato et al., Pharm. Res., 5 (1), 21-30, 1988, Porous biodegradable microspheres for controlled drug delivery.61Scientific American, Aug. 1992, Science and Business, pp. 114-116, Material Help, Bioengineers produce versions of body tissues, by Deborah Erickson.62Spence, Basic Human Anatomy, 1986, p. 63-65.63Structure and Function of Plasma Proteins, vol. 1, Plenum Press, London and New York, pp. 136-137.64Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads, by H.J. Hauselmann, M.B. Aydelotte, B.L. Schumacher, K.E. Kuettner, S.H. Gitelis, and E.J.-M.A. Thonar, Matrix, 12, pp 116-129, (1992).65The Effect of a TCP-Collagen Implant on the Healing of Articular Cartilage Defects in the Rabbit Knee Joint, T. Hogervorst et al., Journal of Applied Biomaterials, vol. 3, pp. 251-258, (1992).66The Effect of the Addition of Low Molecule Weight Poly(DL-lactide) on Drug Release from Biodegradable Poly(DL-lactide) Drug delivery Systems, R. Bodmeier et al., International Journal of Pharmaceutics, 51, pp. 1-9 (1989).67The Repair of Experimentally Produced Defects in Rabbit Articular Cartilage by Autologous Chondrocyte Transplantation, D.A. Grande et al., Journal of Orthopaedic Research, vol. 7, No. 2, 1989.68The Repair of Full-Thickness Articular Cartilage Defects, N. Kawabe et al., Clinical Orthopaedics and Related Research, No. 268, Jul., 1991, pp. 279-293.69The use of demineralized bone and rib perichondrium composite grafts for the repair of full thickness articular defects, H.P. von Schroeder et al., 36th Annual Mtg, Orthopaedic Research Society, Feb. 5-8, 1990, New Orleans.70The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects, H.P. von Schroeder et al., Journal of Biomedical Materials Research, vol. 25, pp. 329-339 (1991).71The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects, H.P. von Schroeder et al., Society For Biomaterials, May 20-23, 1990.72Towards a synthetic articular cartilage, by P.H. Corkhill, J.H. Fitton, and B.J. Tighe, J. Biomater. Sci. Polymer Edn., 4 (6), pp 615-630, (1993).73Urist et al., Proc. Natl. Acad. Sci. USA, vol. 81, Jan. 1984 pp. 371-375, Purification of Bovine Bone Morphogenetic Protein by Hydroxyapatite Chromatograph.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS7122057Apr 12, 2002Oct 17, 2006Therics, LlcMethod and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applicationsUS7326421Oct 21, 2003Feb 5, 2008Kensey Nash CorporationDevice and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissuesUS7494664 *Sep 27, 2002Feb 24, 2009Japan Science And Technology AgencyComposite biomaterialsUS7708740Jun 30, 2005May 4, 2010Marctec, LlcMethod for total knee arthroplasty and resecting bone in situUS7708741Jun 30, 2005May 4, 2010Marctec, LlcMethod of preparing bones for knee replacement surgeryUS7749229Jul 6, 2010Marctec, LlcTotal knee arthroplasty through shortened incisionUS7806896Nov 25, 2003Oct 5, 2010Marctec, LlcKnee arthroplasty methodUS7806897Jun 30, 2005Oct 5, 2010Marctec, LlcKnee arthroplasty and preservation of the quadriceps mechanismUS7828852 *Mar 9, 2007Nov 9, 2010Marctec, Llc.Inlaid articular implantUS7837736Oct 30, 2007Nov 23, 2010Marctec, LlcMinimally invasive surgical systems and methodsUS7931690Apr 26, 2011Marctec, LlcMethod of resurfacing an articular surface of a boneUS7951394May 31, 2011Kensey Nash CorporationDevice and methods of sequential, regional delivery of multiple cyctotoxic agents and directed assembly of wound repair tissuesUS7959635Jun 14, 2011Marctec, Llc.Limited incision total joint replacement methodsUS7993365Jun 8, 2004Aug 9, 2011Morris Innovative, Inc.Method and apparatus for sealing accessUS8118832Jun 15, 2009Feb 21, 2012Morris Innovative, Inc.Method and apparatus for sealing accessUS8133229Oct 14, 2003Mar 13, 2012Marctec, Llc.Knee arthroplasty methodUS8314084Nov 20, 2012Kensey Nash CorporationDevice and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissuesUS8425522Apr 23, 2013Bonutti Skeletal Innovations LlcJoint replacement methodUS8551525Dec 23, 2010Oct 8, 2013Biostructures, LlcBone graft materials and methodsUS8613938Nov 15, 2011Dec 24, 2013Zimmer Orthobiologics, Inc.Bone void fillersUS8623030Mar 14, 2013Jan 7, 2014Bonutti Skeletal Innovations LlcRobotic arthroplasty system including navigationUS8632552Mar 14, 2013Jan 21, 2014Bonutti Skeletal Innovations LlcMethod of preparing a femur and tibia in knee arthroplastyUS8641726Mar 14, 2013Feb 4, 2014Bonutti Skeletal Innovations LlcMethod for robotic arthroplasty using navigationUS8690874Aug 3, 2010Apr 8, 2014Zimmer Orthobiologics, Inc.Composition and process for bone growth and repairUS8697139Sep 21, 2004Apr 15, 2014Frank M. PhillipsMethod of intervertebral disc treatment using articular chondrocyte cellsUS8742072Mar 29, 2010Jun 3, 2014Zimmer Orthobiologics, Inc.Bone growth particles and osteoinductive composition thereofUS8784495Jun 8, 2010Jul 22, 2014Bonutti Skeletal Innovations LlcSegmental knee arthroplastyUS8834490Oct 29, 2013Sep 16, 2014Bonutti Skeletal Innovations LlcMethod for robotic arthroplasty using navigationUS8840629Oct 29, 2013Sep 23, 2014Bonutti Skeletal Innovations LlcRobotic arthroplasty system including navigationUS8858557Oct 29, 2013Oct 14, 2014Bonutti Skeletal Innovations LlcMethod of preparing a femur and tibia in knee arthroplastyUS8974493Feb 21, 2012Mar 10, 2015Morris Innovative, Inc.Method and apparatus for sealing accessUS9060797Aug 5, 2014Jun 23, 2015Bonutti Skeletal Innovations LlcMethod of preparing a femur and tibia in knee arthroplastyUS9101443Feb 29, 2012Aug 11, 2015Bonutti Skeletal Innovations LlcMethods for robotic arthroplastyUS9192459Apr 22, 2014Nov 24, 2015Bonutti Skeletal Innovations LlcMethod of performing total knee arthroplastyUS9220596Oct 7, 2013Dec 29, 2015Biostructures, LlcBone graft materials and methodsUS20030065400 *Apr 12, 2002Apr 3, 2003Beam Heather AnnMethod and apparatus for engineered regenrative biostructures such as hydroxyapatite substrates for bone healing applicationsUS20030114936 *Jul 29, 2002Jun 19, 2003Therics, Inc.Complex three-dimensional composite scaffold resistant to deliminationUS20040126426 *Oct 21, 2003Jul 1, 2004Brekke John H.Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissuesUS20050049637 *Jun 8, 2004Mar 3, 2005Morris Edward J.Method and apparatus for sealing accessUS20050085922 *Oct 18, 2004Apr 21, 2005Shappley Ben R.Shaped filler for implantation into a bone void and methods of manufacture and use thereofUS20050177237 *Oct 18, 2004Aug 11, 2005Ben ShappleySpinal cage insert, filler piece and method of manufacturingUS20060004408 *Jul 13, 2005Jan 5, 2006Morris Edward JMethod and apparatus for sealing accessUS20060111778 *Oct 27, 2005May 25, 2006Michalow Alexander EMethods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathwayUS20060172918 *Sep 27, 2002Aug 3, 2006Shinichi SotomeComposite biomaterialsUS20060246150 *May 15, 2006Nov 2, 2006Thorne Kevin JComposition and Process for Bone Growth and RepairUS20070038244 *Oct 11, 2006Feb 15, 2007Morris Edward JMethod and apparatus for sealing accessUS20070038245 *Oct 11, 2006Feb 15, 2007Morris Edward JDilatorUS20070041950 *Feb 1, 2006Feb 22, 2007Osteobiologics, Inc.Method and device for selective addition of a bioactive agent to a multi-phase implantUS20090024106 *Jul 17, 2007Jan 22, 2009Morris Edward JMethod and apparatus for maintaining accessUS20090208586 *Mar 20, 2007Aug 20, 2009Jms. Co., Ltd.porous bioabsorbable material and method of producing the sameUS20110206648 *Aug 25, 2011Mason James MGene-enhanced tissue engineeringUS20110237858 *Sep 29, 2011Kensey Nash CorporationDevice and Methods for Sequential, Regional Delivery of Multiple Cytotoxic Agents and Directed Assembly of Wound Repair TissuesWO2004037311A2Oct 21, 2003May 6, 2004Kensey Nash CorporationDevice and methods for sequential, regional delivery of multiple cytotoxic agents* Cited by examinerClassifications U.S. Classification623/23.72, 623/23.76International ClassificationA61F2/30, A61F2/02, A61F2/00, A61L27/20, A61F2/28Cooperative ClassificationA61F2002/30062, A61F2/30756, A61L27/20, A61F2250/0067, A61F2002/30677, A61F2/28, A61F2210/0004European ClassificationA61L27/20, A61F2/28Legal EventsDateCodeEventDescriptionFeb 6, 2001ASAssignmentOwner name: KENSEY NASH CORPORATION, PENNSYLVANIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THM BIOMEDICAL, INC.;REEL/FRAME:011511/0218Effective date: 20010130Sep 30, 2004FPAYFee paymentYear of fee payment: 4Aug 8, 2008FPAYFee paymentYear of fee payment: 8Dec 27, 2012FPAYFee paymentYear of fee payment: 12RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services