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Patent US5871719 - Perfume-free two phase compositions for reducing body odor - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe present invention relates to a perfume-free odor absorbing composition, which is safe for use on skin comprising from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; from about 0.1% to about 36%, by weight of the composition, of an oil...http://www.google.com/patents/US5871719?utm_source=gb-gplus-sharePatent US5871719 - Perfume-free two phase compositions for reducing body odorAdvanced Patent SearchPublication numberUS5871719 APublication typeGrantApplication numberUS 08/871,857Publication dateFeb 16, 1999Filing dateJun 9, 1997Priority dateJun 9, 1997Fee statusLapsedPublication number08871857, 871857, US 5871719 A, US 5871719A, US-A-5871719, US5871719 A, US5871719AInventorsJuliet Marie Lucas, Toan Trinh, Robert Gregory Bartolo, Michael Thomas Dodd, Robin Yager Buckner, Theresa Marie KajsOriginal AssigneeThe Procter & Gamble CompanyExport CitationBiBTeX, EndNote, RefManPatent Citations (31), Non-Patent Citations (30), Referenced by (11), Classifications (44), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetPerfume-free two phase compositions for reducing body odor
US 5871719 AAbstract
The present invention relates to a perfume-free odor absorbing composition, which is safe for use on skin comprising from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, skin protectants, and mixtures thereof; one or more surfactants each having a hydrophilic/lipophilic balance of about 8-18, and wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 25% a level of odor capture as an aqueous cyclodextrin solution; and an aqueous carrier. The odor absorbing compositions of the present invention may also contain an effective amount of hydrophobic antimicrobials.
1. An odor absorbing composition comprising:a. from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; b. from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; c. one or more surfactants each having a hydrophilic/lipophilic balance of about 8-18 and wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 25% a level of odor capture as an aqueous cyclodextrin solution; and d. an aqueous carrier;wherein the composition is safe for use on the skin. 2. The composition according to claim 1 wherein the surfactant is selected from the group consisting of block copolymers of polyoxyethylene-polyoxypropylene, polyalkyleneoxide polysiloxanes, and mixtures thereof.
3. The composition according to claim 2 wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 75% of odor capture as an aqueous cyclodextrin solution.
4. The composition according to claim 1 wherein the composition further comprises one or more antimicrobials selected from the group consisting of hydrophobic antimicrobials, water soluble antimicrobials, and mixtures thereof.
5. The composition according to claim 1 wherein the composition further comprises one or more adjunct odor controlling materials selected from the group consisting of zinc salts, zeolites, activated carbon, water-soluble carbonates, water-soluble bicarbonates, and mixtures thereof.
6. The composition according to claim 1 wherein the cyclodextrin is selected from the group consisting of beta-cyclodextrins, derivatives of beta-cyclodextrins, alpha-cyclodextrins, derivatives of alpha-cyclodextrins, gamma-cyclodextrins, derivatives of gamma-cyclodextrins, and mixtures thereof.
7. The composition according to claim 1 wherein the cyclodextrin is selected from the group consisting of methylated cyclodextrin, hydroxypropyl beta-cyclodextrin, and mixtures thereof.
8. A composition comprising the composition according to claim 1 deposited on a flexible dispensing means.
9. An odor absorbing composition comprising:a. from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; b. from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; c. one or more surfactants each having a hydrophilic/lipophilic balance of about 8-18 and wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 25% a level of odor capture as an aqueous cyclodextrin solution; d. a hydrophobic antimicrobial; and e. an aqueous carrier;wherein the composition is safe for use on the skin. 10. The composition according to claim 9 wherein the hydrophobic antimicrobial is selected from the group consisting of triclosan, triclocarbon, eucalyptol, methylsalicylate, and thymol; and is present at a level of from about 0.1% to about 1.5% by weight of the composition.
11. The composition according to claim 9 wherein the surfactant is selected from the group consisting of block copolymers of polyoxyethylene-polyoxypropylene, polyalkyleneoxide polysiloxanes, and mixtures thereof.
12. The composition according to claim 11 wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 75% of odor capture as an aqueous cyclodextrin solution.
13. The composition according to claim 9 wherein the composition further comprises one or more antimicrobials selected from the group consisting of hydrophobic antimicrobials, water soluble antimicrobials, and mixtures thereof.
14. The composition according to claim 9 wherein the composition further comprises one or more adjunct odor controlling materials selected from the group consisting of zinc salts, zeolites, activated carbon, water-soluble carbonates, water-soluble bicarbonates, and mixtures thereof.
15. The composition according to claim 9 wherein the cyclodextrin is selected from the group consisting of beta-cyclodextrins, derivatives of beta-cyclodextrins, alpha-cyclodextrins, derivatives of alpha-cyclodextrins, gamma-cyclodextrins, derivatives of gamma-cyclodextrins, and mixtures thereof.
16. The composition according to claim 9 wherein the cyclodextrin is selected from the group consisting of methylated cyclodextrin, hydroxypropyl beta-cyclodextrin, and mixtures thereof.
17. A composition comprising the composition according to claim 9 deposited on a flexible dispensing means.
18. A process for making an odor absorbing composition comprising the steps of:a. making a mixture by mixing one or more surfactants, an oil phase, and an aqueous phase until the mixture is homogenous; b. making a second mixture by adding cyclodextrin to the mixture of step a with mixing until the cyclodextrin dissolves and the second mixture is homogenous. 19. The process according to claim 18 further comprising making a premix by mixing a hydrophobic antimicrobial and a second aqueous phase until the premix is homogenous; and adding the premix to the mixture in step 18(a) and mixing until the mixture is homogenous.
20. An odor absorbing composition comprising:a. from about 0.1% to about 5%, by weight of the composition, of solubilized, water-soluble, uncomplexed cyclodextrin; b. from about 0.1% to about 36%, by weight of the composition, of an oil phase selected from the group consisting of emollients, moisturizers, and skin protectants; c. one or more surfactants each having a hydrophilic/lipophilic balance of about 8-18 and wherein each surfactant, when combined with an aqueous cyclodextrin solution, provides no less than about 25% a level of odor capture as an aqueous cyclodextrin solution; d. an effective amount of solubilized sodium hydroxymethylglycinate; and e. an aqueous carrier;wherein the composition is safe for use on the skin. Description
Thus, there remains a need for a perfume-free odor absorbing composition, which is essentially free of astringent antiperspirants and which is safe and effective for use on the entire body. More particularly, there is a need for a convenient, leave on composition which is capable of absorbing a broad spectrum of body odors that are not fully suppressed by the aforementioned means.
It has been discovered that such enhanced body odor control can be safely provided to the entire body by application of a composition, which is left on the skin, which incorporates odor absorbing, uncomplexed cyclodextrins into a two phase solution. It has also been discovered that the aforementioned benefits may be delivered in a two phase solution which also optionally delivers skin aid benefits to the user such as protection and/or moisturization.
The present invention relates to a perfume-free odor-absorbing composition which is useful in reducing body odor and/or vaginal odor on skin. The present invention also relates to the odor absorbing compositions deposited on a flexible dispensing means. The present invention also relates also relates to use of an article of manufacture comprising the odor-absorbing composition deposited on a flexible dispensing means.
Concentrated compositions can also be used. When a concentrated product is used, i.e., when the level of cyclodextrin used is from about 3% to about 5%, it is preferable to dilute the composition before applying to the skin in order to avoid tacky skin feel and/or an undesirable amount of residue. Preferably the cyclodextrin is diluted with about 50% to about 2000%, more preferably with about 60% to about 1000%, most preferably with about 75% to about 500%, by weight of the composition, of water.
OIL PHASE: The present invention also includes an oil phase. The oil phase is chosen from the following ingredients: skin protectants, emollients, and/or moisturizers. Saturated or hydrogenated oils are preferred. These ingredients enhance the skin feel characteristics and/or skin care benefits of the present invention. Additionally, the oil phase provides a medium in which hydrophobic antibacterials, if present, may be dissolved.
Skin protectant ingredients can prevent or reduce chafing, skin irritation and/or skin friction that may occur between skin-to-skin contact sites. Preferred skin protectants useful in the present invention include, but are not limited to: vitamin A, cod liver oil, cocoa butter, shark liver oil, dimethicone, petrolatum, white petrolatum, mineral oil, jojoba oil, and lanolin. More preferred are dimethicone, petrolatum, white petrolatum, mineral oil, jojoba oil, and lanolin. Most preferred are the dimethicones.
Moisturizers which aid in adding moisture to the skin may be included in the oil carrier of the present invention. Preferred moisturizers include, but are not limited to vegetable oils and mineral oil. More preferred are hydrogenated or saturated vegetable or mineral oils. Other moisturizers can be chosen from the oily moisturizers in Cosmetic Bench Ref. 1994, pages 46-48, incorporated herein by reference.
Emollients for softening and soothing of skin are also useful in the present invention. Emollients useful herein include tocopherol or tocopherol acetate, triglycerides, vegetable oils, or mineral oil. Other emollients can be chosen from the oily emollients in Cosmetic Bench Ref. 1994, pages 27-31, incorporated herein by reference.
The oil phase or carrier is present at an "effective level", a level which provides the desired skin benefits of the particular ingredients. Typically, the oil phase is present at a level of from about 0.1% to about 26%, preferably from about 0.2% to about 6%, by weight of the composition.
SURFACTANT: A surfactant must be used in the present invention. Surfactants are known in the art of forming oil-in-water emulsions. Preferably, a combination of surfactants are used for improved stability.
Surfactants suitable for use herein are surfactants which do not have a high level of interaction with the cyclodextrin, thus optimizing the odor absorbing capability of cyclodextrin. Extensive interaction is not desirable as it may diminish the ability of the cyclodextrin to complex with odor causing compounds and the ability of the surfactant to blend the oil and water phases.
The surfactants optimize both the odor absorbing characteristic of cyclodextrin and the blending ability of the surfactant. Such surfactants, when added to an aqueous cyclodextrin solution, provide a surfactant/cyclodextrin solution which demonstrate odor absorption similar to the same cyclodextrin solution without the surfactant. Not desirable are surfactants which, when added to an aqueous cyclodextrin solution, provide a surfactant/cyclodextrin solution which demonstrate odor absorption similar to pure water.
The surfactants can be identified using the procedure which follows. First, within an equilibrium chamber, a paper membrane is sealed to a test cell and wetted with a test sample mixture; or, for purposes of establishing a water control and a cyclodextrin control, the membrane is wetted with water or aqueous cyclodextrin. Test sample mixtures comprise mixtures of a solution of aqueous cyclodextrin and a surfactant or a combination of surfactants. Second, an odor causing challenge compound is injected into the equilibrium chamber and allowed to equilibrate through the paper membrane. The odor causing challenge compounds selected should be those which uncomplexed cyclodextrin is capable of absorbing such as isovaleric acid. Third, after a finite time air in the equilibrium chamber enveloping the test cell is pulled through a Drager tube, which results in a color change within the Drager tube. (Drager tubes are commercially available from Lab Safety, Danesville, Wis.). The distance of color movement up the Drager tube corresponds to the remaining (or uncomplexed) concentration of odorous material within the Drager tube. Replicates of this entire procedure are performed and averages are taken. Any similar procedure such as Gas Chromatograph Head Space Analysis may also be used.
The results from each test sample mixture are then compared to the results of the water control and the cyclodextrin control. As used herein, the phrase "odor capture" refers to the amount of cyclodextrin which complexes with the challenge compound. Thus, a high level of odor capture results in a low level of remaining challenge compound. The surfactant should provide a surfactant/cyclodextrin solution which demonstrates more odor capture than the water control. Preferred surfactants provide a surfactant/cyclodextrin solution which demonstrates no less than about 25%, more preferred no less than about 50%, and even more preferred no less than about 75%, of the level of odor capture as the cyclodextrin control. Most preferred surfactants provide the same level of odor capture as the cyclodextrin control.
Additionally, it is preferable for formation of oil-in-water emulsions that the selected surfactant have a hydrophilic/lipophilic balance ("HLB") of about 8-18. The term HLB is known in the art, for example in U.S. Pat. No. 2,677,700 to Jackson et al., issued May 4, 1954, and incorporated herein by reference. Because of the uniqueness of many of the surfactants mentioned below, they will demonstrate lipophilic behavior different from hydrocarbon lipophiles. Consequently, the HLB values may not correlate exactly with the HLB values for ethylene oxide/hydrocarbon surfactants. Overall, the preferred surfactants for use herein include block copolymers of ethylene oxide and/or propylene oxide and polyalkyleneoxide polysiloxanes. Most preferred are mixtures of at least one of each of block copolymers of ethylene oxide and/or propylene oxide and polyalkyleneoxide polysiloxanes.
Block polyoxyethylene-polyoxypropylene polymeric compounds which are compatible with most cyclodextrins include those based on ethylene glycol, propylene glycol, glycerol, trimethylolpropane and ethylenediamine as the initial reactive hydrogen compound. Polymeric compounds made from a sequential ethoxylation and propoxylation of initial compounds with a single reactive hydrogen atom, such as C12-18 aliphatic alcohols, are not generally compatible with the cyclodextrin. Block polymer surfactant compounds designated Pluronic� and Tetronic� are commercially available from the BASF-Wyandotte Corp.
Typical block copolymers of ethylene oxide and/or propylene surfactants include:
Pluronic� surfactants: H(EO)n (PO)m (EO)n H;
Reverse Pluronic� surfactants: H(PO)n (EO)m (PO)n H;
Tetronic� surfactants: ##STR1## and/or Reverse Tetronic� surfactants: ##STR2## wherein EO is an ethylene oxide group, PO is a propylene oxide group, and n and m are numbers that indicate the average number of the groups in the surfactants. The average molecular weight of the polyoxypropylene polymers in the mixture is between about 900 to about 25,000 and the oxyethylene groups constitute between about 10 to about 90 weight percent of the oxyethylene/oxypropylene mixture. Non-limiting examples of surfactants useful herein having an HLB of about 8 to 18 include: Pluronic� surfactants L10, L43, L44, L63, L64, L65, P75, P84, P85, P103, P104, P105, P123, and mixtures thereof; Reverse Pluronic� surfactants 10R5, 17R4,17R8, 22R4,25R4, 25R5, 25R8, and mixtures thereof; Tetronic� surfactants: 304, 504, 704, 707, 904, 1104, 1304, 1504, and mixtures thereof; and Reverse Tetronic� surfactants 50R4, 50R8, 70R4, 90R8, 110R7150R8, and mixtures thereof; and mixtures thereof.
More detailed examples of the aforementioned surfactants and methods of making them are described in U.S. Pat. No. 2,674,619, Lundsted et al., issued Apr. 6, 1954; U.S. Pat. No. 3,036,118, Jackson et al., issued May 22, 1962; and U.S. Pat. No. 2,979,528, Lundsted et al., issued Apr. 11, 1961; all incorporated herein by reference in their entireties.
Polyalkyleneoxide polysiloxanes are defined by the general formula: ##STR3## wherein a+b are from about 1 to about 50, preferably from about 3 to about 30, more preferably from about 10 to about 25, and R1 is mainly one or more random or block poly(ethyleneoxide/propyleneoxide) copolymer groups having the general formula:
--(CH2)n O(C2 H4 O)c (C3 H6 O)d R2 wherein n is 3 or 4, preferably 3; total c (for all polyalkyleneoxy side groups) has a value of from 1 to about 100, preferably from about 6 to about 100; d is from 0 to about 14, preferably from 0 to about 3; and more preferably d is 0; c+d has a value of from about 5 to about 150, preferably from about 9 to about 100 and each R2 is the same or different and is selected from the group consisting of hydrogen, an alkyl having 1 to 4 carbon atoms, and an acetyl group, preferably hydrogen and methyl group. Examples of such compounds suitable herein include: Silwet� L-7600, L-7602, L-7604, L-7605, L-7657, and mixtures thereof; all commercially available from OSi Specialties, Endicott, N.Y.
The molecular weight of the oxyalkylene group (R1) is less than or equal to 10000. Preferably, the molecular weight of the oxyalkylene group is less than or equal to about 8000, and most preferably ranges from about 300 to 5000. Thus, the values of c and d can be those numbers which provide molecular weights within these ranges. However, the number of oxyethylene units (--C2 H4 O) in the polyoxyalkylene groups (R1) must be sufficient to render the polyalkyleneoxide polysiloxane water dispersible or water soluble. It is understood that when c is a positive number, the oxyethylene and oxypropylene units (--C3 H6 O) can be distributed randomly throughout the polysiloxane chain or in respective blocks of oxyethylene and oxypropylene units or a combination of random and block distributions. The preparation of polyalkyleneoxide polysiloxanes is well known in the art. Such compounds can be prepared according to the procedure set forth in U.S. Pat. No. 3,299,112, incorporated herein by reference.
The total surfactant level used in the present compositions is from about 0.05% to about 15%, more preferably from about 0.1 % to about 12%, by weight of the composition. If a hydrophobic antimicrobial agent is included, more surfactant(s) should be included, typically from about 0.5% to about 10%, by weight of the composition.
HYDROPHOBIC ANTIBACTERIAL AGENTS: Optionally, the present invention may include hydrophobic antibacterial compounds to help destroy and/or control the amount of bacteria present on the skin, which aids in body odor control. However, hydrophobic antibacterial agents can form inclusion complexes with the cyclodextrin molecules and compete with the malodorous molecules for the cyclodextrin cavities, thus rendering the cyclodextrins ineffective as odor controlling actives. To account for this, the level of cyclodextrin may be adjusted as desired. Hydrophobic antibacterials useful in the present invention include triclosan, triclocarbon, eucalyptol, menthol, methylsalicylate, thymol, and mixtures thereof. Preferred are triclosan and triclocarbon. When included in the composition of the present invention, the hydrophobic antibacterials may be at a level of from about 0.1% to about 1.5% and preferably from about 0.1% to about 0.3%, by weight of the composition.
pH: Aqueous compositions of the present invention should have a pH of from about 3 to about 10, preferably from about 3.5 to about 8, more preferably from about 3.5 to about 6. Some conventional buffering agents are known in the prior art which may be used to adjust the pH to the desired level if necessary. For example, combinations of salts and acids, such as the following examples: sodium lactate, sodium citrate, potassium phosphate, lactic acid, citric acid, phosphoric acid, sodium hydroxide, and hydrochloric acid are useful. Some of the effectiveness of these ingredients may be lost as they complex with the cyclodextrin, so care is taking in formulating to adjust for that. Other optional buffers appear in The Theory and Practice of Industrial Pharmacy, Lachman, Lieberman and Kanig, Third Edition, incorporated herein by reference.
Optionally, but highly preferred, the present invention can include zinc salts for added odor absorption and/or antimicrobial benefit for the cyclodextrin solution. Zinc compounds have been used to ameliorate malodor, e.g., in mouth wash products, as disclosed in U.S. Pat. Nos. 4,325,939, issued Apr. 20, 1982 and 4,469,674, issued Sept. 4, 1983, to N. B. Shah, et al., both of which are incorporated herein by reference in their entireties. Highly-ionized and water soluble zinc salts, such as zinc chloride, provide the best source of zinc ions. Zinc phenolsulfonate is preferred for use in the skin composition of the present invention; although others may also fall within the scope of the present invention. However, care must be taken in selecting zinc salts as well as their levels, since some may be irritants to the skin and therefore are not preferred for use in the present invention.
Aminocarboxylic acid chelating agents such as ethylenediaminetetraacetic acid (EDTA) can optionally be added to the composition of the present invention (preferably in the absence of any added metal ions) in order to enhance the activity of the water-soluble, antimicrobial preservative. When a chelating agent is added to the composition of the present invention, it is typically present at a level of from about 0.001% to about 0.3%, preferably from about 0.01% to about 0.2% by weight of the composition.
The compositions may be prepared by oil-in-water emulsion techniques such as are commonly known in the art. Examples of such techniques are described in Remington's Pharmaceutical Science, Eighteenth Edition, pp. 304-306, 1990, incorporated herein by reference. The compositions of the present invention also may be prepared by a process comprising the steps of: Making a first mixture by mixing surfactant(s) and an oil phase until homogenous and adding an aqueous phase with mixing until the mixture is homogenous. Making a solution by adding cyclodextrin to an aqueous phase with mixing until the cyclodextrin dissolves. Making a second mixture by mixing the solution with the first mixture until the second mixture is homogenous. Where desired, the second mixture may be diluted by adding an aqueous phase with mixing until homogenous. Where hydrophobic antimicrobials also comprise the compositions, the process of making the mixture in the first step additionally comprises adding a premix with mixing to the surfactant(s) and the oil phase until homogenous, wherein the premix is prepared by mixing a hydrophobic antimicrobial with surfactant(s) until the premix is homogenous. The term "homogenous", as used herein, means a uniformly dispersed solution. Homogeneity is indicated by a substantially smooth, lump-free and uniform appearing composition. A stable emulsion remains homogeneous over a given period which is determined by the required shelf life of the composition.
As an alternative to making the mixture by mixing surfactant(s), an oil phase, optional hydrophobic antimicrobials, and an aqueous phase; an emulsion concentrate comprising surfactant(s), an oil phase, and a minimal amount of aqueous carrier may be used. Emulsion concentrates useful in the present invention will be from about a 3-fold to about a 20-fold concentrate. The concentrated emulsion may then be diluted by adding aqueous carrier followed by addition of the remaining ingredients as discussed above.
Other variations of processes of making the compositions of the present invention should be readily apparent to those having ordinary skill in the art. For instance, the mixture could be made in one step by addition and mixing of each of the ingredients. Alternatively, less than all of the ingredients may be pre-combined for subsequent combination with other ingredients or with other pre-combined ingredients to form the composition.
Equipment suitable for forming the mixtures and emulsion may be selected from those which are known or become known in the art. For example, suitable apparatii include dual propeller blade mixers. A turbine mixer and an in-line homogenizer using tandem rotor-stators, as described in the above-referenced U.S. Pat. No. 5,043,155, may also be used.
The resultant emulsion containing the ingredients in their total amounts has a preferred viscosity at room temperature (i.e., 20�-25� C.) in the range of from about 10 to about 200 centipoise more preferably from about 15 to about 150 centipoise; most preferably from about 20 to about 100 centipoise.
Techniques for combining the wipe substrates with the compositions herein are well known in the art. Examples of common techniques include coating, immersing, dipping, or spraying the wipe substrates with the compositions herein. The compositions herein are added to the wipe substrate at level sufficient to provide the desired odor control and/or other desired skin benefits. A convenient method of combining the composition with the chosen substrate is to place the substrate inside an open package which will ultimately house the finished product until use. The composition is poured onto the substrate and allowed to distribute throughout. It is preferred that the homogenous composition is poured onto each wipe individually rather than onto a stack of wipes. The package is then closed and the wipes ready for use.
The compositions can also be delivered as a liquids via a spray dispenser or a bottle.
Preferred is a manually activated spray dispenser to avoid the use of aerosols which may be irritating to sensitive areas of the body. Spray dispensers are described more fully in U.S. Pat. No. 5,534,165 which is incorporated herein by reference in its entirety.
The following non-limiting examples illustrate perfume compositions and odor absorbing compositions of the present invention.
______________________________________          Example                 Example  Example          I      II       III______________________________________Pluronic � L-44       0.15     0.30Pluronic � L-43            0.207657et L �                     0.307605et L �            0.157600et L �   0.20Dimethicone      2.00     1.00     2.00Triclosan                          0.15Hydroxy Propyl Beta Cyclodextrin            1.00     5.00     2.00Zinc Phenolsulfonate            1.01     1.01Ascorbic Acid    0.40     1.75     2.00Glydant � Plus            0.30     0.30     0.30Suttocide � A         0.25Propylene Glycol 1.00     1.00     1.00Water            Balance  Balance  Balance______________________________________
Alternatively, the hydroxy propyl beta cyclodextrin in the above examples could be substituted with other beta cyclodextrins, alpha-cyclodextrins, gamma-cyclodextrins, or mixtures of these cyclodextrins and/or their derivatives. Similarly, the examples could comprise other hydrophobic antimicrobials.
Prepare Examples I-III as follows: Prepare a premix by mixing triclosan with about 1/6, by weight, of total Pluronic� L and Silwet� L (Example III only). Prepare a first mixture by mixing about 1% of water, by total formula weight, with surfactant. For Example III, preparing the first mixture also includes a final step of adding the premix with mixing. Using a sonifier, prepare a second mixture by adding dimethicone to the first mixture, then slowly adding about 1%-2% of water, by total formula weight. Prepare premix (a) by mixing hydroxypropyl beta cyclodextrin and about 1.5%-3% of water, by total formula weight; premix (b) by mixing zinc phenolsulfonate and about 2% of water, by total formula weight; premix (c) by mixing the ascorbic acid and about 2% of water by total formula weight; and premix (d) by mixing Glydant� Plus and propylene glycol. Using a homogenizer, add remaining water to the second mixture to create a third mixture. Add premixes (a), (b), (c), and (d) to the third mixture using the homogenizer.
Preparation for Application to Skin: The solutions of the present invention may be loaded onto a wipe or poured into a spray device or poured directly onto the skin or flexible dispensing means of the user's choosing for convenient application to the skin. To prepare wipes, place dry fabric or wipe substance inside an open package which will ultimately contain the finished product. Pour the composition onto the fabric to distribute throughout. Close the package for storage until consumer use. To prepare spray, pour the composition into the selected spray package. Close the package for storage until consumer use.
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odor absorbentsUS6702951Jul 13, 2001Mar 9, 2004Robinson Laboratories, Inc.Applied to apparel to be worn during hunting or observation to avoid being sensed by animals; suppressing odorsUS6767553Dec 18, 2001Jul 27, 2004Kimberly-Clark Worldwide, Inc.Carboxylic acid-based odor control agent, especially citric, malic or tartaric acid; and an organosilicone polymer binder.US6852904Dec 18, 2001Feb 8, 2005Kimberly-Clark Worldwide, Inc.Neutralized with carboxylic acid odor control agent, suppressing ammonia odor; for use as absorbent diaper, underpants, incontinence product, sanitary napkins, medical clothingsUS7820873Oct 24, 2002Oct 26, 2010Kimberly-Clark Worldwide, Inc.Absorbent structure comprising synergistic components for superabsorbent polymer* Cited by examinerClassifications U.S. Classification424/65, 424/76.4, 422/5, 424/717, 424/78.03, 424/76.21, 424/67, 424/642, 424/76.2, 424/76.1, 424/76.8, 424/69, 424/715, 424/405International ClassificationA61K8/49, A61K8/891, A61Q15/00, A61K8/73, A61K8/34, A61K8/27, A61K8/44, A61K8/37, A61K8/90, A61K8/19Cooperative ClassificationA61K8/37, A61K8/347, A61K8/738, A61K8/27, A61K8/4973, A61Q15/00, A61K8/19, A61K8/44, A61K8/90, A61K8/891European ClassificationA61K8/34F, A61K8/44, A61K8/37, A61K8/891, A61K8/49H, A61K8/19, A61K8/27, A61K8/90, A61K8/73T, A61Q15/00Legal EventsDateCodeEventDescriptionApr 15, 2003FPExpired due to failure to pay maintenance feeEffective date: 20030216Feb 18, 2003LAPSLapse for failure to pay maintenance feesSep 3, 2002REMIMaintenance fee reminder mailedJan 8, 1998ASAssignmentOwner name: PROCTER & GAMBLE COMPANY, THE, OHIOFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LUCAS, JULIET MARIE;TRINH, TOAN;BARTOLO, ROBERT GREGORY;AND OTHERS;REEL/FRAME:008894/0705Effective date: 19971211RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services