Source: https://patents.google.com/patent/US9056201B1/en
Timestamp: 2018-03-22 15:50:07
Document Index: 163689280

Matched Legal Cases: ['Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No, 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'Application No. 61', 'art 2013']

US9056201B1 - Methods and devices for minimally-invasive delivery of radiation to the eye - Google Patents
Methods and devices for minimally-invasive delivery of radiation to the eye Download PDF
US9056201B1
US9056201B1 US14011516 US201314011516A US9056201B1 US 9056201 B1 US9056201 B1 US 9056201B1 US 14011516 US14011516 US 14011516 US 201314011516 A US201314011516 A US 201314011516A US 9056201 B1 US9056201 B1 US 9056201B1
US14011516
Michael Voevodsky
Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannulas with afterloading systems for introducing radionuclide brachytherapy sources to the cannulas, for example following insertion and positioning of the cannulas. The afterloaders may house the radionuclide brachytherapy source in a vault and connect to the cannula via a guide tube. The afterloaders can advance and retract the source and ensure accurate placement of the source within the cannula.
This application claims priority to U.S. patent application Ser. No. 13/872/941, filed Apr. 29, 2013, which is a division of U.S. patent application Ser. No. 12/350,079, filed Jan. 7, 2009, which is a non-provisional of U.S. Provisional Application No. 61/010,322, filed Jan. 7, 2008, U.S. Provisional Application No. 61/033,238, filed Mar. 3, 2008, U.S. Provisional Application No. 61/035,371, filed Mar. 10, 2008, and U.S. Provisional Application No. 61/047,693, filed Apr. 24, 2008, the specification(s) of which is/are incorporated herein in their entirety by reference.
This application also claims priority to U.S. patent application Ser. No. 13/742,823, filed Jan. 16, 2013, which is a continuation of U.S. patent application Ser. No. 12/497,644, filed Jul. 3, 2009, which is a continuation-in-part of U.S. patent application Ser. No. 12/350,079, filed Jan. 7, 2009, which is a non-provisional of U.S. Provisional Application No. 61/010,322, filed Jan. 7, 2008, U.S. Provisional Application No. 61/033,238, filed Mar. 3, 2008, U.S. Provisional Application No, 61/035,371, filed Mar. 10, 2008, and U.S. Provisional Application No. 61/047,693, filed Apr. 24, 2008, the specification(s) of which is/are incorporated herein in their entirety by reference.
This application also claims priority to U.S. patent application Ser. No. 13/111,780, filed May 19, 2011, which is a non-provisional of U.S. Provisional Application No. 61/347,226, filed May 21, 2010; and a continuation-in-part of U.S. patent application Ser. No. 12/497,644, filed Jul. 3, 2009, which is a continuation-in-part of U.S. patent application Ser. No. 12/350,079, filed Jan. 7, 2009, which is a non-provisional of U.S. Provisional Application No. 61/010,322, filed Jan. 7, 2008, U.S. Provisional Application No. 61/033,238, filed Mar. 3, 2008, U.S. Provisional Application No. 61/035,371, filed Mar. 10, 2008, and U.S. Provisional Application No. 61/047,693, filed Apr. 24, 2008, the specification(s) of which is/are incorporated herein in their entirety by reference.
This application also claims priority to U.S. patent application Ser. No. 12/917,044, filed Nov. 1, 2010, which is a non-provisional of U.S. Provisional Application No. 61/257,232, filed Nov. 2, 2009 and U.S. Provisional Application No. 61/376,115, filed Aug. 23, 2010, the specification(s) of which is/are incorporated herein in their entirety by reference.
This application also claims priority to U.S. patent application Ser. No. 13/111,765, filed May 19, 2011, which is a non-provisional of U.S. Provisional Application No. 61/347,233, filed May 21, 2010, the specification(s) of which is/are incorporated herein in their entirety by reference.
This application also claims priority to U.S. patent application Ser. No. 13/953,528, filed Jul. 29, 2013, which is a non-provisional of U.S. Provisional Application No. 61/676,783, filed Jul. 27, 2012, the specification(s) of which is/are incorporated herein in their entirety by reference.
The present invention relates to methods and devices for introducing radiation to the eye, e.g., the posterior portion of the eye, for treating and/or managing eye conditions including but not limited to macular degeneration.
The present invention features methods and devices for minimally-invasive delivery of radiation to the eye, e.g., the posterior portion of the eye. For example, the present invention features cannulas and afterloading systems (e.g., remote afterloading systems) for introducing radionuclide brachytherapy sources (RBS) to the cannulas for irradiating targets (e.g., targets of the eye). The RBS may be, for example, introduced into the cannula via an afterloading system following cannula insertion and positioning.
The present invention features methods of irradiating a target of an eye in a patient. In some embodiments, the method comprises (a) inserting a cannula into a potential space between a sclera and a Tenon's capsule of the eye of the patient, wherein the cannula is operatively connected to an afterloading system having a radionuclide brachytherapy source (RBS); (b) positioning the RBS over the target; (c) irradiating the target with the RBS; and (d) removing the cannula.
In some embodiments, the method comprises (a) inserting a cannula into a potential space between a sclera and a Tenon's capsule of the eye of the patient, wherein the cannula is operatively connected to an afterloading system having a radionuclide brachytherapy source (RBS); (b) placing a distal portion of the cannula on or near the sclera and positioning a treatment position(s) of the cannula (e.g., of the distal portion of the cannula) near the target; (c) advancing the RBS from the afterloading system through the cannula (100) to the treatment position(s) in the distal portion of the cannula; (d) exposing the target to the RBS; (e) retracting the RBS; and (f) removing the cannula.
In some embodiments, the method comprises (a) inserting a cannula into a potential space between a sclera and a Tenon's capsule of the eye of the patient; (b) placing a distal portion of the cannula on or near the sclera and positioning a treatment position(s) of the distal portion of the cannula near the target; (c) operatively connecting an afterloading system having a radionuclide brachytherapy source (RBS) to the cannula; (d) advancing the RBS from the afterloading system through the cannula to the treatment position(s) in the distal portion of the cannula; (e) exposing the target to the RBS; and (f) retracting the RBS; and (g) removing the cannula.
In some embodiments, the afterloading system comprises (a) a vault for storage of the RBS, wherein the RBS is attached to an advancing means; (b) a guide tube extending from the vault, wherein the guide tube is removably attachable to the cannula; and (c) a source-drive mechanism operatively connected to the advancing means, wherein the source-drive mechanism advances the RBS through the guide tube to the treatment position(s) in the cannula. In some embodiments, the source-drive mechanism retracts the RBS from the treatment position(s).
In some embodiments, the source-drive mechanism comprises a motor. In some embodiments, the motor comprises drive rollers or belts. In some embodiments, the source-drive mechanism is operatively connected to a computer or other controller. In some embodiments, the computer or other controller is operatively connected to a control console, the control console allows for manipulation of the computer or other controller. In some embodiments, the afterloading system measures dwell time of the RBS in the treatment position(s).
In some embodiments, the afterloading system moves the RBS from the vault to the treatment position(s) at a rate of between about 0.01 m/s to about 4 m/s. In some embodiments, the afterloading system moves the RBS from the vault to the treatment position(s) at a rate of between about 2 m/s. In some embodiments, the RBS is a high-dose-rate (HDR) source. In some embodiments, the RBS provides a dose rate of between about 2 to 10 Gy/min to the target. In some embodiments, the RBS provides a dose rate of between about 1 to 10 Gy/min to the target. In some embodiments, the RBS provides a dose rate of between about 2 to 6 Gy/min to the target. In some embodiments, the RBS provides a dose rate of about 4.4 Gy/min to the target.
In some embodiments, the cannula comprises a distal portion and a proximal portion connected by an inflection point, the distal portion has a radius of curvature between about 9 to 15 mm and an arc length between about 25 to 35 mm and the proximal portion has a radius of curvature between about an inner cross-sectional radius of the cannula and about 1 meter. In some embodiments, the cannula is flexible. In some embodiments, the cannula has a fixed shape.
In some embodiments, the afterloader system is operatively connected to the cannula after the cannula is positioned in between the Tenon's capsule and sclera. In some embodiments, the afterloader system is operatively connected to the cannula before the cannula is positioned in between the Tenon's capsule and sclera. In some embodiments, both (a) the afterloader system is operatively connected to the cannula and (b) the RBS is advanced before the cannula is positioned in between the Tenon's capsule and sclera.
The present invention also features brachytherapy systems. In some embodiments, the brachytherapy system comprises (a) a cannula for insertion into a potential space between a sclera and a Tenon's capsule of an eye of a patient; and (b) an afterloading system operatively connected to the cannula. In some embodiments, the afterloading system comprises: a vault for storage of a radionuclide brachytherapy source (RBS), wherein the RBS is attached to an advancing means; a guide tube extending from the vault, wherein the guide tube is removably attachable to the cannula; and a source-drive mechanism operatively connected to the advancing means, wherein the source-drive mechanism advances the RBS through the guide tube to the treatment position(s) in the cannula. In some embodiments, the afterloader system is attached to the cannula via a connector.
FIG. 1 shows an in-use view of a cannula of the present invention.
FIG. 2 shows a schematic view of an afterloading system attachable to a cannula.
FIG. 3 shows a schematic view of an afterloading system of the present invention. Afterloading systems are well known to one of ordinary skill in the art. The present invention is not limited to the afterloading systems described herein.
FIG. 4A shows the advancing means and RBS within the guide tube.
FIG. 4B shows the guide tube connecting to the cannula.
100 cannula
110 distal portion of cannula
118 treatment position
120 proximal portion of cannula
130 inflection point of cannula
150 connector (optional)
400 radionuclide brachytherapy source (RBS)
700 afterloading system
710 vault
720 guide tube
722 advancing means (e.g., guide wire)
730 source-drive mechanism
732 motor
740 computer (e.g., microprocessor)
744 control console
Referring now to FIG. 1-4, the present invention features methods and devices for minimally-invasive delivery of radiation to the eye, e.g., the posterior portion of the eye. For example, the present invention features afterloading systems (700) (e.g., remote afterloading systems) for introducing a radionuclide brachytherapy source (RBS) (400) to a cannula (100). The cannula (100) may be adapted for insertion into a potential space between the sclera and the Tenon's capsule of the eye of a patient.
The present methods and devices may be effective for treating and/or managing a condition (e.g., an eye condition). For example, the present methods and devices may be used to treat and/or manage wet (neovascular) age-related macular degeneration. The present methods are not limited to treating and/or managing wet (neovascular) age-related macular degeneration. For example, the present methods may also be used to treat and/or manage conditions including macular degeneration, abnormal cell proliferation, choroidal neovascularization, retinopathy (e.g., diabetic retinopathy, vitreoretinopathy), macular edema, and tumors (e.g., intra ocular melanoma, choroidal melanoma, retinoblastoma).
As shown in FIG. 1, the cannula (100) comprises a distal portion (110) and a proximal portion (120) connected by an inflection point (130). The distal portion (110) is generally for placement around a portion of the globe of the eye. In some embodiments, the distal portion (110) has a radius of curvature between about 9 to 15 mm and an arc length between about 25 to 35 mm. In some embodiments, the proximal portion (120) has a radius of curvature between about an inner cross-sectional radius of the cannula (100) and about 1 meter. The cannula (100), or a portion thereof, may be flexible, fixed-shape, or a combination thereof. The cannula (100) is not limited to the aforementioned dimensions and configurations.
The cannula (100) may be operatively connected to an afterloading system (700) having a radionuclide brachytherapy source (RBS) (400). The afterloading system (700) can deliver the RBS (400) to the cannula (100) (e.g., to a treatment position (118) of the cannula (100), to at least one treatment position, to one or more treatment positions, etc.). For example, the afterloading system (700) can direct the RBS (400) to a position within the cannula (100) (e.g., a treatment position (118), at least one treatment position, one or more treatment positions, etc.) such that the RBS (400) is over a target. The RBS (400) can then irradiate the target for a length of time desired. The afterloading system (700) may also function to remove the RBS (400) from the position within the cannula (e.g., the treatment position(s) (118)) and from the cannula (100) altogether. For example, the afterloading system (700) may retract the RBS (400) to its starting position outside of the cannula (100).
The cannula (100) may comprise one or more treatment positions (118). The afterloading system (700) may function to deliver one or more RBSs (400) to one or more treatment positions (118).
In some embodiments, the cannula (100) is inserted, e.g., into the potential space between the sclera and the Tenon's capsule, and is positioned appropriately prior to attachment of the afterloading system (700). For example, the distal portion (110) of the cannula is placed on or near the sclera and the treatment position(s) (118) of the cannula (100) (e.g., in the distal portion (110)) or treatment position(s), is positioned near the target. Following placement and positioning of the cannula, the afterloading system (700) may be connected to the cannula. In some embodiments, the cannula (100) and the afterloading system (700) are connected prior to insertion of the cannula (100), e.g., into the potential space between the sclera and the Tenon's capsule.
Afterloading System
The afterloading system (700) may allow for accurate placement of the RBS (400), e.g., at the treatment position(s) (118) within the cannula (100). Afterloading systems (700) are well known to one of ordinary skill in the art and any appropriate afterloading system (700) may be utilized. For example, in some embodiments, the afterloading system (700) comprises a vault (710) for temporary housing of the RBS (400). The RBS (400) may be attached to an advancing means (722) (e.g., a guide wire). In some embodiments, the RBS (400) may be incorporated into the advancing mean (722) (e.g., guide wire). The advancing means (722) (e.g., guide wire) may be constructed from any appropriate material including but not limited to nitinol and stainless steel. A guide tube (720) extends from the vault (710) and is connected to the cannula (100). In some embodiments, the guide tube (720) connects, e.g., removably connects, to the cannula (100) via a connector (150). In some embodiments, the connector (150) is disposed on the cannula (100), e.g., on the proximal portion (120) of the cannula (100). The advancing means (722) directs the RBS (400) through the guide tube (720), e.g., the advancing means (722) may be disposed in at least a portion of the guide tube (720).
The afterloading system (700) comprises a source-drive mechanism (730) operatively connected to the advancing means (722) (e.g., guide wire). The source-drive mechanism (730) functions to advance the advancing means (722) (e.g., guide wire) and RBS (400) through the guide tube (720) to the treatment position(s) (118) in the cannula (100). In some embodiments, the source-drive mechanism (730) comprises a motor (732). In some embodiments, the motor (732) comprises drive rollers or belts.
In some embodiments, the afterloading system (700) comprises a computer (740) (e.g., a microprocessor) or other controller (e.g., an analog or a mechanical control system). The motor (7320) and/or source-drive mechanism (730) may be operatively connected to the computer (740) or other controller. In some embodiments, the computer (740) or other controller is operatively connected to a control console (744). The control console (744) allows for manipulation of the computer (740) or other controller. For example, the control console (744) may allow for programming of the afterloading system (700), e.g., dwell time of the RBS (400) in the treatment position(s) (118), speed of delivery of the RBS (400), etc. In some embodiments, the afterloading system (700) moves the RBS (400) from the vault (710) to the treatment position(s) (118) at a rate of between about 0.01 m/s (1 cm/s) to about 4 m/s. In some embodiments, the afterloading system (700) moves the RBS (400) from the vault (710) to the treatment position(s) (118) at a rate of about 2 m/s.
The afterloading system (700) may measure various parameters of the treatment. For example, in some embodiments, the afterloading system (700) measures dwell time of the RBS (400) in the treatment position(s) (118).
In some embodiments, the guide tube (720) is constructed from a material that provides some shielding from the radiation emitted from the RBS (400) as it travels through the guide tube (720)
In some embodiments, the afterloader system (700) further comprises a selector, for example for treatments that require multiple applicators or cannulas (100). The selector may provide multiple channels, e.g., between 1 to 10 channels, between 2 to 10 channels, between 2 to 20 channels, between 16 to 24 channels, between 18 to 24 channels, more than 24 channels, etc. The selector may facilitate the movement (e.g., entry, transfer) of the RBS (400) through multiple applicators (e.g., cannulas (100)), if necessary.
Radionuclide Brachytherapy Source
The methods and devices of the present invention may feature any appropriate RBS (400). In some embodiments, the RBS (400) is a high-dose-rate (HDR) source. In some embodiments, the RBS (400) is a low-dose-rate (LDR) source. In some embodiments, the RBS (400) is a pulsed-dose-rate (PDR) source. In some embodiments, the RBS (400), e.g., HDR source, delivers a dose rate greater than 100 cGy per minute for a length of time. However the present invention is not limited to a HDR source that delivers a dose rate greater than 100 cGy per minute. In some embodiments, the RBS (400) provides a dose rate of between about 2 to 10 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of between about 1 to 10 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of between about 2 to 6 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of about 4.4 Gy/min to the target. In some embodiments, a LDR source provides a dose rate of less than about 2 Gy/hour. In some embodiments, a medium-dose-rate (MDR) source provides a dose rate of between about 2 to 12 Gy/hour. In some embodiments, a HDR source provides a dose rate of greater than about 12 Gy/hour.
In some embodiments, the RBS (400) provides a dose rate of greater than about 10 Gy/min. In some embodiments, the RBS (400) provides a dose rate of greater than about 11 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of greater than about 12 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of greater than about 13 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of greater than about 14 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate of greater than about 15 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 10 to 15 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 15 to 20 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 20 to 30 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 30 to 40 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 40 to 50 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 50 to 60 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 60 to 70 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 70 to 80 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 80 to 90 Gy/min. In some embodiments, the RBS (400) provides a dose rate between about 90 to 100 Gy/min. In some embodiments, the RBS (400) provides a dose rate of greater than 100 Gy/min.
In some embodiments, the RBS (400) provides a dose rate between about 15 to 20 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 20 to 25 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 25 to 30 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 30 to 35 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 35 to 40 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 40 to 50 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 50 to 60 Gy/min to the target. In some embodiments, the RBS provides a dose rate between about 60 to 70 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 70 to 80 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 80 to 90 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate between about 90 to 100 Gy/min to the target. In some embodiments, the RBS (400) provides a dose rate greater than about 100 Gy/min to the target,
1. A method of irradiating a target of an eye in a patient, said method comprising:
(a) inserting a cannula (100) into a potential space between a sclera and a Tenon's capsule of the eye of the patient, the cannula (100) is operatively connected to an afterloading system (700) having a radionuclide brachytherapy source (RBS) (400);
(b) placing a distal portion (110) of the cannula (100) on or near the sclera and positioning a treatment position (118) of the distal portion (110) of the cannula (100) near the target;
(c) advancing the RBS (400) from the afterloading system (700) through the cannula (100) to the treatment position (118) in the distal portion (110) of the cannula (110);
(d) exposing the target to the RBS (400);
(e) retracting the RBS (400); and
(f) removing the cannula (100).
2. The method of claim 1, wherein the afterloading system (700) comprises:
(a) a vault (710) for storage of the RBS (400), wherein the RBS (400) is attached to an advancing means (722);
(b) a guide tube (720) extending from the vault (710), the guide tube (720) is removably attachable to the cannula (100); and
(c) a source-drive mechanism (730) operatively connected to the advancing means (722), wherein the source-drive mechanism (730) advances the RBS (400) through the guide tube (720) to the treatment position (118) in the cannula (100) and retracts the RBS (400) from the treatment position (118).
3. The method of claim 2, wherein the source-drive mechanism (730) is operatively connected to a computer (740) or other control system.
4. The method of claim 3, wherein the computer (740) or other control system is operatively connected to a control console (744), the control console (744) allows for manipulation of the computer (740) or other control system.
5. The method of claim 1, wherein the afterloading system (700) measures dwell time of the RBS (400) in the treatment position (118).
6. The method of claim 1, wherein the RBS (400) provides a dose rate of between about 1 to 10 Gy/min to the target.
7. The method of claim 1, wherein the cannula (100) comprises a distal portion (110) and a proximal portion (120) connected by an inflection point (130), the distal portion (110) has a radius of curvature between about 9 to 15 mm and an arc length between about 25 to 35 mm and the proximal portion (120) has a radius of curvature between about an inner cross-sectional radius of the cannula (100) and about 1 meter.
8. The method of claim 1, wherein the afterloader system (700) is operatively connected to the cannula (100) after the cannula (100) is positioned in between the Tenon's capsule and sclera.
9. The method of claim 1, wherein the afterloader system (700) is operatively connected to the cannula (100) before the cannula is positioned in between the Tenon's capsule and sclera.
10. The method of claim 1, wherein both (a) the afterloader system (700) is operatively connected to the cannula (100) and (b) the RBS (400) is advanced before the cannula (100) is positioned in between the Tenon's capsule and sclera.
11. A method of irradiating a target of an eye in a patient, said method comprising:
(a) inserting a cannula (100) into a potential space between a sclera and a Tenon's capsule of the eye of the patient;
(c) operatively connecting an afterloading system (700) having a radionuclide brachytherapy source (RBS) (400) to the cannula (100);
(d) advancing the RBS (400) from the afterloading system (700) through the cannula (100) to the treatment position (118) in the distal portion (110) of the cannula (110);
(e) exposing the target to the RBS (400); and
(f) retracting the RBS (400); and
(g) removing cannula (100).
12. The method of claim 11, wherein the afterloading system (700) comprises:
13. The method of claim 12, wherein the source-drive mechanism (730) is operatively connected to a computer (740) or other control system.
14. The method of claim 13, wherein the computer (740) or other control system is operatively connected to a control console (744), the control console (744) allows for manipulation of the computer (740) or other control system.
15. The method of claim 11, wherein the afterloading system (700) measures dwell time of the RBS (400) in the treatment position (118).
16. The method of claim 11, wherein the RBS (400) provides a dose rate of between about 1 to 10 Gy/min to the target.
17. The method of claim 11, wherein the cannula (100) comprises a distal portion (110) and a proximal portion (120) connected by an inflection point (130), the distal portion (110) has a radius of curvature between about 9 to 15 mm and an arc length between about 25 to 35 mm and the proximal portion (120) has a radius of curvature between about an inner cross-sectional radius of the cannula (100) and about 1 meter.
18. A method of irradiating a target of an eye in a patient, said method comprising:
(b) positioning the RBS (400) over the target;
(c) irradiating the target with the RBS (400); and
(d) removing the cannula (100).
19. The method of claim 18, wherein the afterloading system (700) comprises:
(c) a source-drive mechanism (730) operatively connected to the advancing means (722), wherein the source-drive mechanism (730) advances the RBS (400) through the guide tube (720) to a treatment position (118) in the cannula (100).
20. The method of claim 19, wherein the source-drive mechanism (730) is operatively connected to a computer (740) or other control system.
US14011516 2008-01-07 2013-08-27 Methods and devices for minimally-invasive delivery of radiation to the eye Active 2029-03-18 US9056201B1 (en)
US1032208 true 2008-01-07 2008-01-07
US3323808 true 2008-03-03 2008-03-03
US3537108 true 2008-03-10 2008-03-10
US4769308 true 2008-04-24 2008-04-24
US12350079 US8430804B2 (en) 2008-01-07 2009-01-07 Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US12497644 US20100004499A1 (en) 2008-01-07 2009-07-03 Methods And Devices For Minimally-Invasive Extraocular Delivery of Radiation To The Posterior Portion Of The Eye
US25723209 true 2009-11-02 2009-11-02
US34722610 true 2010-05-21 2010-05-21
US34723310 true 2010-05-21 2010-05-21
US37611510 true 2010-08-23 2010-08-23
US12917044 US20110207987A1 (en) 2009-11-02 2010-11-01 Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
US13111765 US8602959B1 (en) 2010-05-21 2011-05-19 Methods and devices for delivery of radiation to the posterior portion of the eye
US13111780 US8608632B1 (en) 2009-07-03 2011-05-19 Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
US201261676783 true 2012-07-27 2012-07-27
US13742823 US8597169B2 (en) 2008-01-07 2013-01-16 Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US13872941 US20130267758A1 (en) 2008-01-07 2013-04-29 Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US201313953528 true 2013-07-29 2013-07-29
US14011516 US9056201B1 (en) 2008-01-07 2013-08-27 Methods and devices for minimally-invasive delivery of radiation to the eye
US14486401 US9873001B2 (en) 2008-01-07 2014-09-15 Methods and devices for minimally-invasive delivery of radiation to the eye
US12917044 Continuation-In-Part US20110207987A1 (en) 2009-11-02 2010-11-01 Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
US13111780 Continuation-In-Part US8608632B1 (en) 2008-01-07 2011-05-19 Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
US13111765 Continuation-In-Part US8602959B1 (en) 2010-05-21 2011-05-19 Methods and devices for delivery of radiation to the posterior portion of the eye
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US14011516 Continuation-In-Part US9056201B1 (en) 2008-01-07 2013-08-27 Methods and devices for minimally-invasive delivery of radiation to the eye
US12497644 Continuation-In-Part US20100004499A1 (en) 2008-01-07 2009-07-03 Methods And Devices For Minimally-Invasive Extraocular Delivery of Radiation To The Posterior Portion Of The Eye
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US20050085415A1 (en) * 2002-02-14 2005-04-21 Matthias Wiesner Methods and compositions for the treatment of eye diseases
Au et al.; Localised abscess following an injection of subtenon triamcinolone acitonide; Correspondence; Eye (2007) 21, 627-674, doi:10.1038/sj.eye.6702671; published online Dec. 15, 2006.
Baum, M.D. et al.; The Evolution of Antibiotic Therapy for Facterial Conjunctivitis and Keratitis: 1970-2000; pp. 659-672; Cornea, vol. 19, No. 5, 2000; Lippincott Williams & Wilkins, Inc., Philadelphia.
Canavan et al.; Sub-Tenon's administration of local anaesthetic: a review of the technique; 2003; pp. 787-793; British Journal of Anaesthesia.
COMS Coordinating Center; Collaborative Ocular Melanoma Study; Manual of Procedures; Jan. 1995; pp. 1-330; The Wilmer Ophthalmological Institute; The Johns Hopkins School of Medicine (*reduced to cover and Table of Contents due to excessive data [330 pages]).
Dafflon et al.; Posterior sub-Tenon's steriod injections for the treatment of posterior ocular inflammation: indications, efficacy and side effects, Graefe's Arch Clin Exp Ophthalmos, 1999, pp. 289-295; Springer-Verlag 1999.
Golden; SubTenon Injection of Gentamicin for Bacterial Infections of the Eye; pp. S271-S277; The Journal of Infectious Diseases; vol. 124, Supplement; Dec. 1971; University of Chicago.
Hubbard et al.; A New Ocular Brachytherapy System for the Treatment of Exudative AMD; 2005; Invest Ophthalmo Vis Sci 2005; 46; E-Abstract 2425.
Hubbard et al.; Cadaver Evaluation of a New Ocular Brachytherapy System; Invest Ophthalmol Vis Sci 2004; 45: E-Abstract 5139.
Hubbard, III et al.; A Progress Report on the TheraSight Ocular Brachytherapy Safety and Feasibility Study; 2006; Invest Ophthalmol Vis Sci 2006; 47: E-Abstract 2101.
Ikewaki et al.; Peribulbar fungal abscess and endophthalmitis following posterior subtenon injection of triamcinolone acetonide; Diagnolis/Therapy in Ophthalmology; 2008; pp. 102-104; Acta Ophthalmologica; The Authors, Journal compilation, Acta Ophthalmol.
J. M. Capping; Radiation scleral necrosis simulating early scleromalacia perforans; Brit. J. Ophthal.; 1973; 57; pp. 425-428.
Jaakkola, Aino; Heikkonen, Jorma; Tarkkanen, Ahti and Immonen, Ilkka; Visual function after strontium-90 plaque irradiation in patients with age-related subfoveal choroidal neovascularization; Acta Opthalmologica Scandinavica 1999; 77; pp. 57-61.
JC Wen et al; Ocular complications following I-125 brachytherapy for choroidal melanoma; Eye; 2009; 23; 1254-1268.
Kusaka et al.; Orbital infection following posterior subtenon triamcinolone injection; 2207; pp. 692-693; Acta Ophthalmologica Scandinavica.
Messmer E et al.; Histopathologic findings in eyes treated with a ruthenium plaque for uveal melanoma; Graefes Arch Clin Exp Opthalmol.; 1992; 230 (4): 391-6.
Nath, Ravinder, Ph.D. et al.; Brachytherapy Physics Second Edition; Medical Physics Monograph No. 31; 1013 pages; Medical Physics Publishing; Madison, Wisconsin, USA; 2005.
Nayak et al.; Acute orbital abscess complicating deep posterior subtenon triamcinolone injection; Indian Journal of Ophthalmology; vol. 56, No. 3; May-Jun. 2008; downloaded from http://www.ijo.in on Monday, Nov. 2, 2009.
Raghava et al.; Periocular routes for retinal drug delivery, 2004, pp. 99-114, Ashley Publications.
Scoper; Review of Third- and Fourth-Generation Fluoroquinolones in Ophthalmology: In-Vitro and In-Vivo Efficacy; Adv Ther. 2008; 25(10): 979-994; Springer Healthcare Communications.
Snyder, MD, PhD et al.; Antibiotic Therapy for Ocular Infection; Conferences and Reviews; pp. 579-584; WJM, Dec. 1994; vol. 161, No. 6; Therapy for Ocular Infection-Snyder and Glasser.
Tenon's Capsule; Fundamentals and Principles; p. 39.
Thach, MD et al.; A Comparison of Retrobulbar versus Sub-Tenon's Corticosteroid Therapy for Cystoid Macular Edema Refractory to Topical Medications; pp. 2003-2008; Ophthalmology Volue 104, No. 12, Dec. 1997.
The Collaborative Ocular Melanoma Study Group; Design and Methods of a Clinical Trial for a Rare Condition: The Collaborative Ocular Melanoma Study; COMS Report No. 3; 1993; Controlled Clinical Trials 14: 362-391; Elsevier Science Publishing Co., Inc.
Venkatesh et al.; Comparison of the Efficacy and Safety of Different Methods of Posterior Subtenon Injection; Ocular Immunology and Inflammation; Oct. 1, 2007; pp. 217-223; Infoma Healthcare USA, Inc.
Venkatesh MD, et al.; Posterior subtenon injection of corticosteroids using polytetrafluoroethylene (PEFE) intravenous cannula; Clinical and Experimental Ophthalmology (2002) 30, 55-57; All India Institute of Medical Sciences Campus, India.
Walker et al.; Conservative management of refractory steroid-induced glaucoma following anterior subtenon steroid injection; 2007; Letters to the Editor; pp. 197-198; The Authors, Journal compilation, Royal Australian and New Zealand College of Ophthalmologists.
Yilmaz, MD et al.; Severe Fungal Keratitis Treated With Subconjunctival Fluconazole; 2003; pp. 454.e1-454.e7; vol. 140, No. 3; Elsevier Inc.
Yilmaz, MD et al.; Severe Fungal Keratitis Treated With Subconjunctival Fluconazole; Apr. 2006; pp. 783-784; vol. 141, No. 4, Correspondence; American Journal of Ophthalmology.
HENSCHKE et al. 1966 Intracavitary radiation therapy of cancer of the uterine cervix by remote afterloading with cycling sources
Merrick et al. 2000 Modiﬁed Uniform Seed Loading for Prostate Brachytherapy: Rationale, Design, and Evaluation
US20060111605A1 (en) 2006-05-25 Methods and apparatus for intraocular brachytherapy
US5084001A (en) 1992-01-28 Method and apparatus for effecting radioactive therapy in an animal body
US20050027156A1 (en) 2005-02-03 Intraocular brachytherapy device and method
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