Source: http://www.google.fr/patents/US9383331
Timestamp: 2017-10-19 12:54:15
Document Index: 455109013

Matched Legal Cases: ['Application No. 60', 'Application No. 2010', 'Application No. 2013', 'Application No. 08755661', 'Application No. 2014', 'Application No. 2', 'Application No. 2', 'Application No. 08755661', 'Application No. 08755661', 'Application No. 2014']

Brevet US9383331 - Measurement and uses of oxidative status - Google Brevets
The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients...http://www.google.fr/patents/US9383331?utm_source=gb-gplus-shareBrevet US9383331 - Measurement and uses of oxidative status
Numéro de publication US9383331 B2
Numéro de demande US 14/016,889
Date de dépôt 3 sept. 2013
Autre référence de publication CA2684144A1, CA2931413A1, EP2147303A1, EP2147303A4, EP2147303B1, US9063070, US20090004686, US20140004551, WO2008144481A1
Numéro de publication 016889, 14016889, US 9383331 B2, US 9383331B2, US-B2-9383331, US9383331 B2, US9383331B2
Inventeurs David Bar-Or, Raphael Bar-Or
Cessionnaire d'origine Aytu Bioscience, Inc.
Citations de brevets (76), Citations hors brevets (111), Classifications (4), Événements juridiques (2)
US 9383331 B2
1. A method of determining when to begin treatment of a patient having a broken bone, the method comprising:
a) at the time of first examination of the patient, measuring the oxidation-reduction potential (ORP) of a body fluid from the patient by contacting the body fluid with an electrode connected to a machine that provides a read out of the ORP; and,
b) comparing the ORP of the body fluid with a normal ORP value;
c) immediately beginning treatment of the patient if the ORP value of the body fluid is statistically greater than the normal ORP value.
2. The method of claim 1, wherein the treatment is antioxidant therapy.
3. The method of claim 1 wherein the ORP is measured in plasma from the patient.
This application is a continuation of U.S. application Ser. No. 12/121,945, filed May 16, 2008, which claims the benefit of U.S. Provisional Application No. 60/938,925, filed May 18, 2007, the complete disclosures of which are incorporated herein by reference.
oxidant+ne−
The method of the present invention has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma. As used herein, “trauma” refers to physical injury to any part of a patient's body or to multiple parts of a patient's body. Trauma injuries include head injuries, internal injuries, blunt trauma, multiple trauma, broken bones and burns.
Oxidation-reduction potential (ORP) measurements were recorded using a micro Pt/AgCl combination MI-800/410 cm Redox Electrode (Microelectrodes, Inc., Bedford, N.H., USA) connected to an HI4222 pH/mV/Temperature bench meter (Hanna Instruments, Woonsocket, R.I., USA). The electrode was immersed in a plasma sample, and a steady-state ORP reading in millivolts (mV) was recorded.
Oxidation-reduction potential (ORP) measurements were recorded at room temperature using a micro Pt/AgCl combination MI-800/410 cm Redox Electrode (Microelectrodes, Inc., Bedford, N.H., USA) connected to an HI4222 pH/mV/Temperature bench meter (Hanna Instruments, Woonsocket, R.I., USA). Plasma samples were thawed, and the ORP electrode was immersed in the plasma. A reading was recorded in millivolts (mV) after the ORP value was stable for 5 seconds.
The ORP, PON-AE and total protein data were analyzed using Matlab R14 (Mathworks, Natick, Mass.). A one-way ANOVA was used to compare all patient data versus normal data to test for significant differences with a Tukey-Kramer correction for multiple comparisons with a significance level of 0.05. All data are reported as ±standard error of the mean (SEM).
The plasma samples were thawed at room temperature. ORP measurements were recorded using an MI-800/410 cm Redox Electrode (Microelectrodes, Inc., Bedford, N.H., USA) connected to an HI4222 pH/mV/Temperature bench meter (Hanna Instruments, Woonsocket, R.I., USA). The electrode was immersed in a plasma sample, and a steady-state ORP reading in millivolts (mV) was recorded.
Average change −3.2
Oxidation-reduction potential (ORP) was measured at room temperature in both the day 1 and day 42 sample supernatants. ORP measurements were recorded using a micro Pt/AgCl MI-800/410 cm Redox Electrode (Microelectrodes, Inc., Bedford, N.H., USA) connected to an HI4222 pH/mV/Temperature bench meter (Hanna Instruments, Woonsocket, R.I., USA). The electrode was immersed in a sample supernatant, and a steady-state ORP reading in millivolts (mV) was recorded.
057A 105.2  124.6
ORP measurements were recorded at room temperature using a micro Pt/AgCl combination MI-800/410 cm Redox Electrode (Microelectrodes, Inc., Bedford, N.H., USA) connected to an HI4222 pH/mV/Temperature bench meter (Hanna Instruments, Woonsocket, R.I., USA). Plasma samples were thawed, and the ORP electrode was immersed in the plasma. A reading was recorded in millivolts (mV) after the ORP value was stable for 5 seconds.
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Classification internationale G01N33/50, G01N27/26
Classification coopérative G01N33/50, G01N27/26
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BAR-OR, DAVID;BAR-OR, RAPHAEL;REEL/FRAME:035425/0924