Source: https://patents.google.com/patent/JP3992617B2/en
Timestamp: 2019-12-08 12:08:34
Document Index: 771142931

Matched Legal Cases: ['art 23', 'art 23', 'art 23', 'art 23', 'art 23', 'art 63', 'art 63', 'art 75', 'art 77']

JP3992617B2 - Device for use in eye surgery - Google Patents
JP3992617B2
JP3992617B2 JP2002545611A JP2002545611A JP3992617B2 JP 3992617 B2 JP3992617 B2 JP 3992617B2 JP 2002545611 A JP2002545611 A JP 2002545611A JP 2002545611 A JP2002545611 A JP 2002545611A JP 3992617 B2 JP3992617 B2 JP 3992617B2
JP2002545611A
JP2004514501A (en
コープマンス，ステフアン
テルウエー，トーマス
エイ・エム・オー・フローニンゲン・ベー・ベー
2001-11-23 Application filed by エイ・エム・オー・フローニンゲン・ベー・ベー filed Critical エイ・エム・オー・フローニンゲン・ベー・ベー
2001-11-23 Priority to PCT/EP2001/013746 priority patent/WO2002043630A2/en
2004-05-20 Publication of JP2004514501A publication Critical patent/JP2004514501A/en
2007-10-17 Publication of JP3992617B2 publication Critical patent/JP3992617B2/en
The present invention relates to a sealing device having a plug portion adapted to seal a capsular rupture portion of a capsular bag, in which an intraocular lens implant is inserted by inserting a lens forming material in order to replace the natural crystalline lens. The present invention relates to a sealing device used in a surgical procedure including forming. The invention also relates to a method for providing vision correction comprising forming an intraocular lens inside a lens capsule after the native lens has been removed.
A technique is under development that removes the natural lens of the cataract and / or presbyopia from the lens capsule of the eye and replaces the natural lens with a lens-forming liquid material that is injected directly into the lens capsule. This is described, for example, in patent application SE0001934-9. The liquid material is a partially polymerized material that is cured in the eye to form a solid lens implant. The lens implant functions as a substitute for the natural lens and aims to substantially restore the function of the natural lens of the young eye. Materials and methods suitable for implantation and subsequent IOL (Intra Ocular Lens) formation are described in patent applications PCT / EP99 / 077781, PCT / EP99 / 07780, PCT / EP99 / 01766, SE0001934-9. Is disclosed. Defective native lens substrates can be removed by conventional surgical methods involving ultrasound probes, for example, phacoemulsification including suction. A capsulotomy is performed to facilitate removal of the lens substrate and refilling of the lens-forming liquid material. That is, a cut sever breakage portion is prepared on the front wall of the lens capsule. The capsular rupture is formed by cutting the lens capsule into a circular or essentially circular shape and generally has a diameter of about 0.5 mm to about 2.5 mm. An injection needle is inserted into the capsular bag through the eye incision and capsular break, thereby allowing the lens-forming liquid material to be injected into the capsular bag.
One problem with the capsular bag filling procedure has been found that liquid material may leak through the capsular rupture during injection and before the final lens is formed. For this reason, a plug is proposed in Japanese Patent Application JP97-308946. This plug is attached to the injection needle and inserted into the eye, and is positioned at the correct position within the break when the injection needle is inserted. The problem with this plug is that the plug is clamped and / or glued in the break. Because the plug is relatively large and is intended to be placed in the break, permanent optical problems can occur. Furthermore, the plug requires a relatively large opening in the eye to be implanted. The plug is also provided with a filling tube, which must be cut after filling. The tube can leak. Also, the size of the plug can affect the free movement of the sac necessary for uniform deformation of the sac during adjustment. International patent application WO 00/49976 (University of Miami) proposes a very simple plug arrangement intended to function as a valve during a surgical procedure. Nevertheless, this plug has the disadvantage that after the operation is finished, part of its structure is permanently placed outside the lens capsule. A curved flexible member permanently projects from the lens capsule through a hub-like attachment to a flexible disc-shaped flap valve member. As a result, this protrusion may endanger the surrounding delicate eye tissue including the iris. Also, the protrusion may cause undesirable optical side effects. It is therefore clear that there is a need to improve the plug or sealing means for the incision rupture introduced in the sac filling process.
An object of the present invention is to provide a sealing device for a capsular rupture portion of an eye capsular bag that effectively prevents liquid inserted into the capsular bag from leaking through the capsular rupture portion.
It is also an object of the present invention to provide a sealing device for a capsular rupture that does not leave a permanent portion outside the lens capsule after the lens implantation procedure is completed.
Another object is to provide a sealing device having means by which its position can be controlled after insertion of the sealing device throughout the capsular bag filling and lens forming procedures.
Yet another object of the present invention is to provide a sealing device for a capsular bag that can compensate for wavefront aberrations and / or refractive index errors in the optical part of the eye.
These objects are achieved by a sealing device having a plug part made of a deformable polymer. The plug part allows entry of the injection device that injects the lens-forming liquid material through the notch rupture part, while having a slightly larger area than the notch rupture part, whereby the injected liquid material The sealing action is obtained by being pressed against the inner capsular bag at the sealing position without a gap by the pressure exerted by. The sealing device further includes removable adjustment means connected to the plug portion and projecting forward. By this adjusting means, the plug portion can be accurately moved to a desired place by the doctor. An important feature of the sealing device of the present invention is that there is no portion protruding from the lens capsule after the surgical procedure. This is because the adjustment means can be easily removed by a surgical incision of the eye, as determined by the physician. As can be seen from the fluid lens forming material, sufficient pressure can be exerted on the deformable seal device, so that the seal device does not leave a permanent part protruding in the posterior chamber of the eye outside the capsular bag. Due to the simple construction, a sufficient seal can be formed with the capsular wall without the need for separate fixing means.
It is preferable that the plug portion is essentially circular, and it is preferable that the plug portion is disposed inside the capsular bag so as to cover the entire notch rupture portion. The plug portion preferably has a slightly larger diameter than the ruptured rupture portion so that reliable sealing can be performed. Accordingly, suitable plug diameters range from about 0.5 mm to about 2.5 mm. However, in certain embodiments described below, the plug portion may extend over a fairly wide range. The plug part of the sealing device is permanently placed in the eye, but instead it may be removed after the lens-forming procedure is completed in the lens capsule and the lens-forming material is completely cured. good. In such a case, the adjustment means is not removed and is used to carefully loosen the plug part and remove it from the eye.
The plug portion is formed of a suitably soft and flexible biocompatible material that is thin enough to follow the adjustment action of the lens capsule. This usually means that the plug portion has a thickness in the range of about 5 micrometers to 250 micrometers. In order to avoid any problems related to material incompatibility, or ultimately to avoid optical side effects, the plug portion may be formed from a material similar to the lens forming material. preferable. The plug portion is preferably formed of a silicon material that is compatible with the injectable lens-forming silicon material. More preferably, the plug portion is formed of a material having essentially the same refractive index as the material inserted into the capsular bag when the notch rupture portion is disposed within the field of view. This is particularly important when the plug portion is left in the lens capsule after the lens formation procedure is completed. Thus, the sealing device does not adversely affect the visual acuity. Suitable silicone materials that are optionally free of UV absorbers and other additives that would be considered unsuitable for application in this technology are mentioned in PCT / EP99 / 077781 and PCT / EP99 / 07780. Silicone materials that can be found in certain terpolymers or that have a high refractive index are disclosed, for example, in US Pat. No. 5,236,970 and US Pat. No. 5,444,106. Also, in certain embodiments of the present invention, a variety of medical grade conventional polydimethylsiloxanes (PDMS) are suitable. The plug portion may be formed using a conventional molding process in silicone, well known to those skilled in the art, along with other suitable silicones other than the silicone described above.
Generally, the adjustment means is one or more thin flexible wires that are not permanently attached to the plug. In a suitable embodiment, the thin wire penetrates the plug part from the front side to the rear side and then penetrates the plug part from the rear side to the front side. The distance between the two penetrating locations and their location on the plug is chosen so that they can be manipulated as desired from outside the eye using micro forceps or other suitable means. It goes without saying that the thin wire may have a length protruding from the eye through the keratotomy. The wire is preferably formed of a material that is less flexible than the material of the plug and the lens capsule, and can be easily removed when the lens-forming material is introduced or after the lens-forming procedure is completed. It is attached. In general, suitable materials for the wire are various brands of nylon well known in surgical procedures and will not be described in further detail.
In one aspect of the present invention, the plug portion of the sealing device includes a plug due to a force acting on the capsular bag wall during the adjustment procedure by increasing contact between the surface of the plug portion and the inner wall (rear wall) of the capsular bag. Contact means are provided to prevent any displacement of the part. In addition, if the cut rupture portion to be sealed extends so widely as to exceed several millimeters, considerable problems arise in order to perform an accurate adjustment procedure. In order to perform an accurate adjustment procedure, it is necessary to accurately transmit the force acting on the lens capsule without forming any dead zone that cannot be involved in the procedure. When forming an adjustment lens using a very soft lens material with a sufficiently low modulus of elasticity, this kind of dead zone and / or large displacement of the plug during adjustment will result in the lens material being adjusted. It is not precisely involved, and in the worst case it bulges forward and becomes uncontrollable. In order to accommodate all such undesirable consequences, the plug portion is preferably provided with contact means for enhancing the contact between the plug portion and the lens capsule wall. Suitable contact means can be achieved by providing the plug part with a front face that can at least partially increase the frictional force against the inner wall of the capsular bag. As an example, this can be achieved by providing a rough front surface in the form of a peripheral ring adapted to enhance contact with the inner wall of the capsular bag. This enhances contact between the sealing device and the inner wall of the lens capsule. Friction enhancing and roughening processes are well known to silicon specialists and will not be discussed in detail here. It is preferred that all areas designated to contact the inner wall of the capsular bag are modified or treated, so that generally about 5% to 50% of the total surface is modified or It is processed.
In another form of the invention, the plug portion of the sealing device has a ring extending forward in the central portion, and the ring has a diameter that fits into the fracture portion from below. The ring is adapted to stabilize the exact position of the sealing device.
In certain embodiments, the plug portion has a cut that allows the lens forming material to pass therethrough. Thereby, the sealing device can hold the position more easily during the injection of the lens forming material. Suitably, the cut is provided with an overlap that is adapted to seal the cut when the injection is complete to prevent undesirable leakage through the cut of the injected lens-forming material.
The sealing device of the present invention can be appropriately positioned within a notch rupture having a diameter of about 1 mm located outside the optical axis of the eye, that is, outside the normal visual field. Alternatively, the notch sever includes the optical axis. In such a case, it is important that the plug portion is optically completely transparent and that the plug portion does not contribute to any optical side effects. In this case, the plug portion is preferably formed of a material having the same or substantially the same refractive index as that of the lens forming material.
In other embodiments of the present invention, the sealing device is formed to have certain predetermined optical properties and to be used within the visual field of the eye. In this case, the sealing device has an extending portion that extends over the entire or substantially entire visual field of the eye, and corrects optical defects including aberrations and refractive errors that typically arise from individual irregularities on the corneal surface. Therefore, it can be formed individually for each patient. In surgical correction procedures aimed at using the optical properties of the sealing device, most anterior lens capsules can be surgically removed, for example, the approximately 2-6 mm lens capsule surrounding the optical axis. . A sealing device having an appropriate extension that fits into the capsular bag thus extracted can be used to correct the visual acuity with respect to optical errors that also occur from other parts of the eye, such as the corneal surface. Can be used in processing. In this case, an optical surface or refractive power capable of correcting aberrations such as astigmatism and / or spherical aberration may be applied to the plug portion of the sealing device. In general, such a sealing device having a lens magnification may be formed of a material having a different refractive index than the injectable lens forming material, and at least one surface deviating from a perfect sphere, i.e., aberration. An aspheric surface may be provided to reduce or eliminate.
The present invention also relates to a method for performing vision correction that includes forming an intraocular lens inside the lens capsule of the eye. This method includes the step of inserting a sealing device into the capsular rupture portion, the plug portion covering the capsular rupture portion from the inside of the capsular bag, and operable from the outside of the capsular bag. Adjusting the location of the sealing device with adjusting means, using the supply means and displacing and / or deforming the plug part to allow the passage of material, through the incision rupture Supplying the lens-forming material into the lens capsule; removing the supply means from the eye and holding the plug portion in a sealed position, thereby preventing the lens-forming liquid material from escaping from the lens capsule and leaking; It is equipped with.
In one embodiment, the method removes the sealing device through the capsular break when the lens forming procedure is complete. Alternatively, when the plug portion is positioned so as to seal the notch rupture portion by the lens forming material inserted into the lens capsule, only the adjusting means is removed. In this method, it is appropriate that the plug portion is deformed into a shape that can be inserted through the notch rupture portion. It is preferable to control the position of the plug portion by adjusting means.
In one embodiment, the method inserts the lens-forming material into the capsular bag through the plug cut and the capsular break.
In addition, the method may include a step of introducing a substance that prevents secondary cataract into the lens capsule before introducing the lens forming material. Such a substance is generally introduced using a syringe, and the plug portion can be displaced or deformed so that the injection needle can be sufficiently inserted into the lens capsule. This plug provides a well-sealed environment that prevents the injected material during the subsequent cataract treatment from coming into contact with other ocular tissues other than the inner wall of the lens capsule. Suitable substances are cytotoxic or antiproliferative substances that prevent the growth of epithelial tissue that can compromise the transparency of the capsular bag after surgery. An example of such a substance is 5-fluorouracil, but many other substances are also conceivable for those skilled in the art. In addition, substances that may inhibit the adhesion of epithelial tissues, such as calcium channel blockers, are useful.
In certain embodiments, the method further measures a refractive error of the eye to form a plug portion that compensates for the refractive error. Also in this embodiment, the method is based on a corneal anatomical method, i.e. by performing wavefront analysis of the aphakic eye using, for example, a Hartmann-Schahck sensor device during a surgical procedure. One or more aberrations are measured. The method may also include an evaluation of aberrations that occur in the wavefront reaching from the lens formed in the lens capsule. The results obtained from these optical measurements can be used to form a plug surface that compensates for eye aberrations, or alternatively from a set of multiple sealing devices with various refractive values and / or aberrations It is preferable to select a sealing device having a plug that provides the individual with the best optical results.
The present invention provides a very advantageous ophthalmic surgical sealing device that is very versatile and easily adaptable to a number of different surgical conditions due to its adaptability to visual circumstances and simplified construction. Obviously it will be done. The following sections are intended to illustrate some specific embodiments of the sealing device, but do not limit the scope of the present invention.
FIG. 1a is a schematic top view of a sealing device 21 according to the first embodiment of the present invention. The sealing device 21 essentially includes a disk-shaped plug portion 23 and an adjusting means 25. The plug portion 23 is formed of a deformable polymer such as a silicon material. In this embodiment, the adjusting means 25 is a nylon thread having a central portion attached to the central portion of the plug portion 23. For example, the two thread ends 26a and 26b of the adjusting means 25 can be directed to the same side from the plug part 23 by passing the thread through the two holes of the plug part 23. Of course, the thread 25 may be attached to the plug portion 23 by other methods, and the thread may be formed of a material other than nylon. Alternatively, only one end of the yarn may be attached to the plug portion 23 and only one end may be oriented away from the plug portion 23. The nylon thread used in this embodiment has a suitable rigidity that can operate the plug portion. The material may have a refractive index compatible with the lens material and must follow the deformation of the capsular bag if the sealing means is to be left in the break.
FIG. 1 b is a side view of the sealing device 21 shown in FIG. 1 a inserted into the capsular bag 28. The plug portion 23 of the sealing device 21 is inserted inside the lens capsule, and covers the fracture portion 30 of the lens capsule from below. The nylon threads 26a and 26b extend forward from the sealing device 21 and preferably have a sufficient length protruding from the eyes. Therefore, the sealing device 21 can be controlled from the outside of the eye and maintained at a desired position. The sealing device 21 is adapted to be inserted into the eye before the lens forming liquid material is injected and after the natural lens is removed.
In injecting the lens-forming material, a supply means, here a syringe, is used. The needle of the syringe is inserted into the incision rupture portion of the capsular sac by piercing the eye and sufficiently displacing and / or deforming the sealing device so that the needle can enter the capsular sac. The After injection, the injection needle is removed from the capsular bag and eye, and the pressure exerted by the fluid lens forming material holds the sealing device in its original position and shape in front of the break. This prevents the lens forming material from leaking out. Here, the lens-forming material can be cured into a final lens implant, and the wire can be removed from the eye using forceps, for example. In practice, it is not necessary to insert the syringe into the lens capsule. It is sufficient if the lens-forming material can be injected toward the broken portion outside the broken portion. In this case, the lens forming material passes through the sealing device and into the lens capsule. If a small amount of lens forming material remains in the anterior chamber of the eye, it is simply washed away with the rinsing solution used during the surgical procedure.
The liquid material may be via other curing mechanisms by a silicon material that cures at ambient body temperature, or a photosensitizer that is activated by light having a selected wavelength as further described in PCT / EP99 / 077781. It may be a silicon material that hardens. When the lens forming fluid fills the lens capsule, the sealing device 21 is pressed against the inner wall around the rupture of the lens capsule by the lens implant. If the sealing device 21 is left in the break, only the adjusting means 25 is removed. Alternatively, the entire sealing device 21 is removed. The plug portion 23 can be deformed by an instrument operated from the outside of the eye, and thus the plug portion can be removed through the fracture portion. The position and size of the break portion may be the same as described with respect to the first embodiment, but when the plug portion is left in the break portion, the break portion is included so as to include the optical axis. It is preferable to position. Moreover, it is preferable that a fracture | rupture part has a diameter larger than 1 mm. Therefore, in order to cover the whole fracture | rupture part, a plug part must also be larger than 1st Embodiment. In practice, the plug portion preferably covers the entire optical path of light that can enter the pupil. If the plug part 23 is left in the eye, the material of the plug part 23 must also have essentially the same refractive index as the lens forming material. When the sealing device 1 is left in the fracture portion 9, the plug portion 2 is preferably formed of a material that can follow the deformation of the lens capsule and has a size as described above. The plug portion 23 in this embodiment is preferably formed so as to further correct the refractive error of the eye. Further, the plug portion may be formed so as to correct a defect in aberration on the optical surface of the eye such as spherical aberration. The measurement required for ocular aberrations and the surface design that needs to be provided on the plug part 23 to compensate for the aberrations are disclosed in detail in patent application SE0001925-7, the contents of which are referred to Are incorporated herein by reference. It is also possible to extract a larger portion of the capsular bag portion than shown in FIG. 1b, so that a larger opening can be formed in the capsular bag and further spread over the entire field of view. Large sealing devices can be used. This creates a notable possibility of providing vision correction that complements what can be done with the injected lens.
FIG. 2 is a top view of a sealing device 41 according to the second embodiment of the present invention. The seal device 41 of the second embodiment mainly follows the sealing device of the first embodiment. The sealing device 41 includes a plug portion 43 and an adjusting means 45. The materials and dimensions are the same, and the application of the sealing device is the same. The difference is that the plug portion 43 is provided with a rough surface 47 at a portion in contact with the inner wall of the lens capsule. The purpose of this rough surface 47 is to maintain the sealing device 41 in the desired location covering the break. The plug portion 43 also has a cut 49 along the radial direction of the disk-shaped plug portion 43. The purpose of this cut 49 is to facilitate the injection needle easily passing through the break during injection and to minimize leakage of injected material through the break during injection. The plug portion 43 is preferably provided with an overlapping portion 51 below the cut 49. The purpose of this overlap 51 is to prevent material from leaking through the break 49 after the needle has been removed. As described above, in order to insert the lens forming material, it is not necessary to bother inserting the injection needle through the broken portion. In this case, however, the cut 49 simplifies the injection.
FIG. 3 is a top view of a sealing device 61 according to the third embodiment of the present invention. The sealing device 61 of the third embodiment also mainly follows the sealing device of the first embodiment. The sealing device 61 includes a plug part 63 and an adjusting means 65. The materials and dimensions are the same, and the application of the sealing device is the same. The difference is that the plug part 63 is provided with a forward projecting ring 67 having a diameter slightly smaller than the diameter of the fractured part on the surface from which the adjusting means 65 projects. The ring 67 is adapted to fit into the break when the plug portion 63 is disposed in the lens capsule, thereby maintaining the sealing device 61 in an accurate position and allowing the break to be inside the lens capsule. Seal from.
FIG. 4 is a side view of the above-described arbitrary type of sealing device 71 inserted into the lens capsule 73 through the breaking portion 75. In this case, the fracture portion 75 is located at a location deviating from the optical axis A of the eye. Here, the breaking part 75 has a diameter of only about 1 mm, and therefore the plug part 77 of the sealing device 71 has a slightly larger diameter. In this case, the sealing device 71 may be left in the lens capsule 73 because it is off the optical axis and does not disturb the visual acuity, and may be removed from the eye. In this case, if the sealing device is small, the sealing device 71 is easily removed.
Of course, the various features described in all these embodiments can be combined in all possible ways.
FIG. 1a is a schematic top view of a sealing device according to a first embodiment of the present invention.
1b is a side view of the sealing device of FIG. 1a inserted into the capsular bag.
FIG. 2 is a top view of a sealing device according to a second embodiment of the present invention.
FIG. 3 is a top view of a sealing device according to a third embodiment of the present invention.
FIG. 4 is a side view of a sealing device according to the present invention inserted into a capsular bag.
A sealing device (1; 21; 41; 61; 71) used in ophthalmic surgery to replace the natural lens of cataracts and / or presbyopia, wherein the capsular rupture of the lens capsule (28; 73) ( 30; 75) a flexible plug portion (23; 43; 63; adapted to seal the incision rupture portion (30; 75) while allowing the injection device to inject the lens-forming liquid material through 30; 75). 77), and the plug portion (23; 43; 63; 77) has a slightly larger area than the capsular rupture portion (30; 75) and is formed of a deformable polymer, Removable adjustment means (25; protruding forward) connected to the plug part (23; 43; 63; 77) and capable of positioning the plug part (23; 43; 63; 77) in a desired location. 45; 5) further comprising a sealing device.
The sealing device according to claim 1, wherein there is no portion protruding from the lens capsule after a surgical procedure.
The sealing device according to claim 1, wherein the plug part (23; 43; 63; 77) is essentially circular.
The said plug part (23; 43; 63; 77) is arrange | positioned inside a lens capsule (28; 73), and covers the said notch | capsular fracture | rupture part (30; 75) whole from Claim 1 4. The sealing device according to any one of 3.
5. The plug part (32; 43; 63; 77) is formed from a suitable soft material and is thin enough to follow the adjustment action of the capsular bag. Sealing device.
The sealing device according to any one of claims 1 to 5, wherein the plug portion (23; 43; 63; 77) is formed of a silicon material.
The plug part (23; 43; 63) is formed from a material having essentially the same refractive index as the material inserted into the lens capsule (7; 28). The sealing device according to item.
The sealing device according to claim 1, wherein the plug portion is provided with contact means capable of performing an accurate adjustment treatment by contacting the lens capsule.
The sealing device according to claim 8, wherein the contact means includes a front surface portion having a higher friction than a rear surface of the plug portion.
10. The sealing device according to claim 9, wherein the sealing device has a rough surface (47) on at least a surface in contact with the inner wall of the lens capsule (7; 28).
A ring (67) extending forward is provided in the middle, and this ring (67) has a diameter that fits the broken portion from below, and stabilizes the position of the sealing device (61) at the broken portion. The sealing device according to claim 1, wherein
The sealing device according to claim 1, wherein the removable adjustment means (25; 45; 65) is at least one flexible thread (25; 45) attached to the plug part (23; 43; 63). .
13. The sealing device according to claim 12, wherein at least one thread (25; 45; 65) projects forward from the plug part (23; 43; 63).
14. The sealing device according to claim 13, wherein at least one thread (25; 45; 65) has a length that protrudes outside the eye and is operable from outside the eye.
The sealing device according to any one of claims 1 to 14, wherein the plug portion (43) has a cut (49) that allows the lens-forming material to pass therethrough.
16. A sealing device according to claim 15, wherein the cut (49) is provided with an overlap (51) adapted to seal the cut (49) when injection is complete.
17. A sealing device according to any one of the preceding claims, wherein the sealing device is arranged at a break (9; 75) having a diameter of about 1 mm located off the optical axis of the eye.
18. A sealing device according to any one of the preceding claims, wherein the sealing device is arranged at a break (30) having a diameter of more than 1 mm positioned to include the optical axis of the eye.
19. A sealing device according to any one of the preceding claims, adapted to remain in the capsular bag (28; 75) after completion of the intraocular lens forming procedure.
20. The sealing device according to claim 18 or 19, wherein the plug part (32; 43) is optically transparent.
19. The sealing device according to claim 18, wherein the plug portion (32; 43) covers the entire optical path of light that can enter the pupil.
The sealing device according to claim 21, wherein the sealing device is configured to compensate for aberrations.
The sealing device according to claim 21 or 22, wherein the sealing device is configured to correct a refraction error in the eye.
24. The sealing device according to any one of claims 1 to 23, wherein the sealing device is adapted to be removed after completion of the intraocular lens forming procedure.
JP2002545611A 2000-11-29 2001-11-23 Device for use in eye surgery Active JP3992617B2 (en)
PCT/EP2001/013746 WO2002043630A2 (en) 2000-11-29 2001-11-23 A device for use in eye surgery
JP2004514501A JP2004514501A (en) 2004-05-20
JP3992617B2 true JP3992617B2 (en) 2007-10-17
JP2002545611A Active JP3992617B2 (en) 2000-11-29 2001-11-23 Device for use in eye surgery
FR2913435B1 (en) 2007-03-07 2009-12-04 Schonherr Textilmaschb Gmbh A weaving comb, a weaving work comprising such a comb and method of manufacturing such a comb.
NZ510807A (en) 1998-10-13 2003-10-31 Pharmacia Groningen Bv Injectable intraocular lens
SE9900632D0 (en) 1999-02-19 1999-02-19 Juerg Schiffmann Rotary piston machine
US8945213B2 (en) 2015-02-03
JP2015507946A (en) 2015-03-16 Modular intraocular lens design and method