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Patent US5580543 - Method of magnetic resonance image enhancement - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsTexaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals...http://www.google.com/patents/US5580543?utm_source=gb-gplus-sharePatent US5580543 - Method of magnetic resonance image enhancementAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS5580543 APublication typeGrantApplication numberUS 08/458,267Publication dateDec 3, 1996Filing dateJun 2, 1995Priority dateJan 21, 1992Fee statusPaidAlso published asCA2173319A1, CA2173319C, DE69432221D1, DE69432221T2, EP0724457A1, EP0724457B1, US5457183, US5583220, US5587371, US5622946, US5632970, US5801229, US6069140, WO1995010307A1Publication number08458267, 458267, US 5580543 A, US 5580543A, US-A-5580543, US5580543 A, US5580543AInventorsJonathan L. Sessler, Tarak D. Mody, Gregory W. Hemmi, Vladimir A. Kr al, Darren MagdaOriginal AssigneePharmacyclics, Inc., Board Of Regents, Univ. Of Texas Sys.Export CitationBiBTeX, EndNote, RefManPatent Citations (38), Non-Patent Citations (243), Referenced by (23), Classifications (80), Legal Events (7) External Links: USPTO, USPTO Assignment, EspacenetMethod of magnetic resonance image enhancement
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A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging, Investigative Radiology, 29(3):330 338, 1994.* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS6022959 *Nov 20, 1997Feb 8, 2000Pharmacyclics, Inc.Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereofUS6495118Sep 24, 1998Dec 17, 2002Schering AktiengesellschaftLipophilic metal complexes for necrosis and infarction imagingUS6638924Aug 28, 2001Oct 28, 2003Pharmacyclics, Inc.Metallotexaphyrin derivativesUS6723750Mar 15, 2002Apr 20, 2004Allergan, Inc.Photodynamic therapy for pre-melanomasUS7067618 *Dec 24, 1999Jun 27, 2006Kyowa Hakko Kogyo Co., Ltd.Medicinal preparationsUS7112671Aug 28, 2001Sep 26, 2006Pharmacyclics, Inc.Non-symmetric tripyrranes in the synthesis of novel macrocyclesUS7449454Sep 10, 2003Nov 11, 2008Pharmacyclics, Inc.Metallotexaphyrin derivativesUS7735544Mar 16, 2009Jun 15, 2010Anastasia KolesnichenkoMethod and system of electromagnetic stirring for continuous casting of medium and high carbon steelsUS8133474Sep 14, 2007Mar 13, 2012Massachusetts Institute Of TechnologySensors for fluorescence and magnetic resonance imagingUS8410263Nov 3, 2009Apr 2, 2013Pharmacyclics, Inc.High-purity texaphyrin metal complexesUS20030064026 *Oct 7, 2002Apr 3, 2003Schering AgLipophilic metal complexes for necrosis and infarction imagingUS20030138432 *Dec 15, 2000Jul 24, 2003Drug Innovation & Design, Inc.Selective cellular targeting: multifunctional delivery vehicles, multifunctional prodrugs, use as antineoplastic drugsUS20030232800 *Aug 28, 2001Dec 18, 2003Mody Tarak DNon-symmetric tripyrranes in the synthesis of novel macrocyclesUS20040171602 *Sep 10, 2003Sep 2, 2004Pharmacyclics, Inc.Novel metallotexaphyrin derivativesUS20060099712 *Nov 8, 2004May 11, 2006Eastman Kodak CompanyCorrelation of anti-cancer activity of dyes with redox potentialsUS20060181579 *Feb 14, 2006Aug 17, 2006Brother Kogyo Kabushiki KaishaInkjet Recording ApparatusUS20070072838 *Sep 26, 2005Mar 29, 2007Pharmacyclics, Inc.High-purity texaphyrin metal complexesUS20070078119 *Sep 30, 2005Apr 5, 2007Pharmacyclics, Inc.Storage system for texaphyrin pharmaceutical formulationsUS20080063605 *May 19, 2005Mar 13, 2008Wai-Fung CheongMethod of Enhancing Visualization of Atherosclerotic PlaqueUS20080138292 *Sep 14, 2007Jun 12, 2008Massachusetts Institute Of TechnologySensors for fluorescence and magnetic resonance imagingUS20090229783 *Mar 16, 2009Sep 17, 2009Anastasia KolesnichenkoMethod and system of electromagnetic stirring for continuous casting of medium and high carbon steelsDE19641197A1 *Sep 24, 1996May 14, 1998Schering AgIonenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als KontrastmittelDE19641197C2 *Sep 24, 1996Feb 18, 1999Schering AgIonenpaare und ihre Verwendung als Kontrastmittel* Cited by examinerClassifications U.S. Classification424/9.34, 534/13, 424/9.362, 514/185, 424/9.361, 424/9.363, 534/11, 424/9.35, 424/9.351, 424/9.341, 540/472, 534/16, 540/465, 534/15, 540/145International ClassificationA61P43/00, A61P35/02, A61K51/00, A61K31/407, B01J31/06, A61K31/40, B01J31/16, A61K41/00, A61K49/08, A61K49/00, A61K51/04, C07H21/00, B01J31/18, C07D487/22, A61K47/48, A61K49/06, A61L2/00Cooperative ClassificationA61K49/10, A61K49/085, B01J2531/96, B01J2531/025, B01J31/1658, B01J2531/842, B01J2531/37, A61K49/0054, B01J2531/845, B01J2531/28, C07H21/00, B01J2531/72, B01J31/061, A61K41/0057, B01J31/1805, B01J2531/38, A61K47/48069, A61K41/0076, A61L2/0011, A61K51/0485, A61K49/126, C07D487/22, B01J2531/26, A61K49/106, B01J2531/36, B01J2531/23, A61K41/0038, B01J31/1815, B01J2531/847, B01J2531/27, A61K49/0021European ClassificationA61K49/10C8, A61K41/00W10, A61K49/00P4F8K, C07H21/00, A61K49/12P, A61K49/10, B01J31/16D2, B01J31/18B, A61K41/00W, A61L2/00P2, A61K41/00P, A61K47/48H4H4, A61K49/08Z, B01J31/18B2B, A61K51/04L16, A61K49/00P4F4C, C07D487/22Legal EventsDateCodeEventDescriptionOct 13, 1998CCCertificate of correctionJun 2, 2000FPAYFee paymentYear of fee payment: 4Jun 3, 2004FPAYFee paymentYear of fee payment: 8Jun 3, 2008FPAYFee paymentYear of fee payment: 12Jun 9, 2008REMIMaintenance fee reminder mailedJul 18, 2015ASAssignmentOwner name: PHARMACYCLICS, INC., CALIFORNIAFree format text: MERGER;ASSIGNOR:OXFORD AMHERST CORPORATION;REEL/FRAME:036130/0254Effective date: 20150526Owner name: PHARMACYCLICS LLC, CALIFORNIAFree format text: MERGER AND CHANGE OF NAME;ASSIGNORS:PHARMACYCLICS, INC.;OXFORD AMHERST LLC;REEL/FRAME:036130/0285Effective date: 20150526May 18, 2016ASAssignmentOwner name: PHARMACYCLICS, INC., CALIFORNIAFree format text: CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036130 FRAME 0254. 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