Source: http://www.google.com/patents/US7897733?dq=6011510
Timestamp: 2015-08-02 05:09:45
Document Index: 521969782

Matched Legal Cases: ['Application No. 2003', 'Application No. 524408', 'Application No. 524408', 'Application No. 2003', 'Application No. 2003', 'Application No. 524408']

Patent US7897733 - Rapamycin conjugates and antibodies - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsProvided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof....http://www.google.com/patents/US7897733?utm_source=gb-gplus-sharePatent US7897733 - Rapamycin conjugates and antibodiesAdvanced Patent SearchPublication numberUS7897733 B2Publication typeGrantApplication numberUS 11/272,070Publication dateMar 1, 2011Filing dateNov 14, 2005Priority dateApr 23, 1993Fee statusLapsedAlso published asUS7279561, US7279562, US20020151088, US20060121545Publication number11272070, 272070, US 7897733 B2, US 7897733B2, US-B2-7897733, US7897733 B2, US7897733B2InventorsKatherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. OcainOriginal AssigneePfizer, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (58), Non-Patent Citations (33), Classifications (30), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetRapamycin conjugates and antibodies
To a solution of 15.9 mg of rapamycin 31,42-diester with glutaric acid in 160 μL of dimethyl formamide was added 3.65 mg of N,N-dimethylaminopropyl-ethylcarbodiimide and 1.8 mg of N-hydroxysuccinimide. The reaction mixture was allowed to stir until reaction was complete, poured into water, and extracted with ethyl 35 acetate. The organic layers were combined, dried over sodium sulfate, filtered, and concentrated in vacuo to give the title compound, which was stored at 4� C. at 0.1 N sodium phosphate buffer and used without further purification.
To 20 mg of keyhole limpet hemocyanin in 2 mL of 0.1 M NaHCO3 was added 55 μL of rapamycin 31,42-diester with (N-hydroxysuccinimide(hemiglutarate)) at 0� C. in 10 μL increments over a 30 min period. The solution was gently shaken until reaction was complete, centrifuged at 6000 rpm for 20 min, and unconjugated starting material was separated from the title compound on a G-25 column with phosphate buffer solution. The conjugate was mixed with glycerol at 50% and stored at −70� C. The number of rapamycin 31,42-diester with glutaric acid moieties per keyhole limpet hemocyanin ranged from 17-45:1
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS3929992Apr 12, 1974Dec 30, 1975Ayerst Mckenna & HarrisonRapamycin and process of preparationUS3993749 *Sep 25, 1975Nov 23, 1976Ayerst Mckenna And Harrison Ltd.Rapamycin and process of preparationUS4208479 *Jul 14, 1977Jun 17, 1980Syva CompanyLabel modified immunoassaysUS4316885Aug 25, 1980Feb 23, 1982Ayerst, Mckenna And Harrison, Inc.Acyl derivatives of rapamycinUS4401653Mar 9, 1981Aug 30, 1983Ayerst, Mckenna & Harrison Inc.Combination of rapamycin and picibanil for the treatment of tumorsUS4650803Dec 6, 1985Mar 17, 1987University Of KansasProdrugs of rapamycinUS4885171Mar 22, 1984Dec 5, 1989American Home Products CorporationUse of rapamycin in treatment of certain tumorsUS5023264Jul 16, 1990Jun 11, 1991American Home Products CorporationRapamycin oximesUS5078999Feb 22, 1991Jan 7, 1992American Home Products CorporationMethod of treating systemic lupus erythematosusUS5080899Feb 22, 1991Jan 14, 1992American Home Products CorporationMethod of treating pulmonary inflammationUS5089390Sep 4, 1987Feb 18, 1992Syntex (U.S.A.) Inc.2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivativesUS5091389Apr 23, 1991Feb 25, 1992Merck & Co., Inc.Lipophilic macrolide useful as an immunosuppressantUS5100883Apr 8, 1991Mar 31, 1992American Home Products CorporationFluorinated esters of rapamycinUS5100899Jun 6, 1989Mar 31, 1992Roy CalneMethods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereofUS5102876May 7, 1991Apr 7, 1992American Home Products CorporationReduction products of rapamycinUS5118677May 20, 1991Jun 2, 1992American Home Products CorporationAmide esters of rapamycinUS5118678Apr 17, 1991Jun 2, 1992American Home Products CorporationCarbamates of rapamycinUS5120842Apr 1, 1991Jun 9, 1992American Home Products CorporationSilyl ethers of rapamycinUS5122511Feb 27, 1990Jun 16, 1992Merck & Co., Inc.Immunosuppressive cyclosporin analogs with modified amino acids at position-8US5130307Feb 19, 1991Jul 14, 1992American Home Products CorporationAminoesters of rapamycinUS5138051Aug 7, 1991Aug 11, 1992American Home Products CorporationRapamycin analogs as immunosuppressants and antifungalsUS5151413Nov 6, 1991Sep 29, 1992American Home Products CorporationRapamycin acetals as immunosuppressant and antifungal agentsUS5164495Sep 18, 1991Nov 17, 1992Abbott LaboratoriesMethod for preparing a dicarboxylic acid half-acid ester of FK506US5169773Oct 31, 1988Dec 8, 1992Sandoz Ltd.Monoclonal antibodies to cyclosporinsUS5169851Apr 29, 1992Dec 8, 1992American Home Products CorporationRapamycin analog as immunosuppressants and antifungalsUS5177203Mar 5, 1992Jan 5, 1993American Home Products CorporationRapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agentsUS5194447Feb 18, 1992Mar 16, 1993American Home Products CorporationSulfonylcarbamates of rapamycinUS5233036Feb 20, 1992Aug 3, 1993American Home Products CorporationRapamycin alkoxyestersUS5252579Feb 16, 1993Oct 12, 1993American Home Products CorporationMacrocyclic immunomodulatorsUS5504091Apr 14, 1994Apr 2, 1996American Home Products CorporationBiotin esters of rapamycinUS5532137Jun 6, 1995Jul 2, 1996Fujisawa Pharmaceutical Co., Ltd.Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay methodUS5665772Sep 24, 1993Sep 9, 1997Sandoz Ltd.O-alkylated rapamycin derivatives and their use, particularly as immunosuppressantsUS5912253Dec 16, 1994Jun 15, 1999Novartis AgRapamycin derivativesUS5985890Jun 5, 1996Nov 16, 1999Novartis AgRapamycin derivativesUS6187547Aug 6, 1998Feb 13, 2001Novartis AgAssay kitUS6328970May 24, 2000Dec 11, 2001American Home Products CorporationRapamycin position 27 conjugatesUS6541612 *Feb 2, 2001Apr 1, 2003WyethMonoclonal antibodies obtained using rapamycin position 27 conjugates as an immunogenUS6635745Jan 9, 2001Oct 21, 2003Novartis AgRapamycin assayUS7279561 *May 24, 2000Oct 9, 2007WyethAnti-rapamycin monoclonal antibodiesUS20020002273Aug 20, 2001Jan 3, 2002Richard SedraniRapamycin assayUS20020022717Jan 9, 2001Feb 21, 2002Richard SedraniRapamycin assayEP0201751A2Apr 17, 1986Nov 20, 1986Abbott Laboratories4'-aminomethyfluorescein derivatives for use in fluorescence polarization immunoassysEP0283801A2Mar 4, 1988Sep 28, 1988Abbott LaboratoriesFluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodiesEP0467606A1Jul 15, 1991Jan 22, 1992American Home Products CorporationRapamycin derivativesEP0473961A2Aug 8, 1991Mar 11, 1992Abbott LaboratoriesImmunoassay reagents and method for determining cyclosporineEP0487289A2Nov 19, 1991May 27, 1992BEHRINGWERKE AktiengesellschaftCyclosporin immunoassayEP0506032A1Mar 25, 1992Sep 30, 1992American Cyanamid CompanyReceptor purification methodEP0507555A1Mar 31, 1992Oct 7, 1992American Home Products CorporationUse of rapamycin for treating diabetesEP0525960A1Jun 9, 1992Feb 3, 1993American Home Products CorporationUse of rapamycin for the treatment of adult T-cell leukemia/lymphomaEP0693132B1Mar 30, 1994Dec 17, 1997Novartis AGRapamycin assayJPS63219394A Title not availableWO1990006763A1Dec 5, 1989Jun 28, 1990Univ ColumbiaNovel derivatives of cyclosporine a, antibodies directed thereto and uses thereofWO1990008957A1Jan 25, 1990Aug 9, 1990Epitope IncAvidin-biotin assisted immunoassayWO1992005179A1Sep 19, 1991Apr 2, 1992American Home ProdCarboxylic acid esters of rapamycinWO1992022332A2Jun 17, 1992Dec 23, 1992Univ CaliforniaDrug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technologyWO1993019752A1Mar 19, 1993Oct 14, 1993Dana Farber Cancer Inst IncInhibition of p70 s6 kinaseWO1993025533A1Jun 1, 1993Dec 23, 1993Abbott LabMethods and reagents for the determination of immunosuppressive agentsWO1994024304A1Mar 30, 1994Oct 27, 1994Sandoz AgRapamycin assay* Cited by examinerNon-Patent CitationsReference1Baeder, Fifth Int. Conf. Inflamm. Res. Assoc., Abstract, p. 121 (1990).2Baker, Antibiot., 31:539 (1978).3Cadoff, Transplantation Proceedings, 22(1):50-51 (1990).4Caine, Lancet, p. 1183 (1978).5Campbell et al, Monoclonal Antibody and Immunosensor Technology, Elsevier, Chapter 1 (1991).6Chen et al, Journal of the American Chemical Society, 116:2683-2684 (1994).7Dumont, FASEB, 3:5256 (1989).8English-language translation of Abstract of JP-63-219394 (Cite No. 3 herein).9English-language translation of Dec. 13, 2005 Official Action in Japanese Patent Application No. 2003-412071.10English-language translation of Jun. 10, 2003 Official Action in Japanese Patent Application No. 524408/94.11English-language translation of May 11, 2004 Official Action in Japanese Patent Application No. 524408/94.12English-language translation of Sep. 28, 2004 Official Action in Japanese Patent Application No. 2003-412071.13English-language translation of Sep. 29, 2009 Official Action on Appeal in Japanese Patent Application No. 2003-412071 (Appeal No. 2006-4633).14English-language translation of Sep. 29, 2009 Official Action on Appeal in Japanese Patent Application No. 524408/94 (Appeal No. 2006-5134).15Gregory, J. Heart Lung Transplant.,11(pt 2):197 (1992).16Holt et al, Chemical Abstracts, vol. 120, No. 25 (1994).17Hultsch et al, Proceedings of the National Academy of Sciences of USA, 88:6229-6233 (1991).18Linskins et al, Immunology in Plant Sciences, pp. 86-141 (1986).19Martel, Can. J. Physiol. Pharmacol., 55:48 (1997).20Meiser, J. Heart Lung Transplant., 9:55 (1992).21Morris, Med. Sci. Res., 17:877 (1989).22 *Nolli et al. Antibodies against the antibiotics: an overview. Ann Ist Super Sanita 1991, vol. 27, Issue 1, pp. 149-154.23Propper, et al, FK506-Its Influence on Anti-Class 1 MHC Alloantibody Responses to Blood Transfusions, Transplantation, Aug. 1990, pp. 267-271, vol. 50, No. 2.24Sehgal, J. Antibiot., 28:727 (1975).25Sevier et al, Clin. Chem., 27(11):1797-1806 (1981).26Staruch, FASEB, 3:3411 (1989).27Stepkowski, Transplantation Proceedings, 21(1):507-508 (1991).28Tamura, Transplantation Proceedings, 19(6):23-29 (1987).29Tsuji, et al, Selective Immunosuppression of Prodigiosin 25-C and FK506 in the Murine Immune System, Oct. 1990, pp. 1293-1301, vol. 43, No. 10.30Van Duyne, et al, Atomic Structure of the Rapamycin Human Immunophilin FKBP-12 Complex, 1991, pp. 7433-7434, vol. 113.31Venzina et al, J. Antibiot., 28:721 (1975).32Woo, et al, Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506, 1988, pp. 153-155, vol. 65.33Yelton et al, American Scientist, 68:510-516 (1980).* Cited by examinerClassifications U.S. Classification530/388.9, 530/403, 435/70.21, 435/345, 435/346International ClassificationC12P21/08, C07K1/04, C12N5/00, C07K16/00, A61K31/435, G01N33/533, A61K47/48, C07K16/12Cooperative ClassificationY10S530/809, A61K31/435, C12N9/0065, G01N33/9446, G01N33/533, A61K47/48284, C07K16/1292, A61K47/48507, C07K16/14European ClassificationG01N33/94D, C07K16/14, C12N9/00P24, G01N33/533, A61K47/48T4, A61K47/48R2L, C07K16/12B28, A61K31/435Legal EventsDateCodeEventDescriptionJul 12, 2011CCCertificate of correctionOct 10, 2014REMIMaintenance fee reminder mailedMar 1, 2015LAPSLapse for failure to pay maintenance feesApr 21, 2015FPExpired due to failure to pay maintenance feeEffective date: 20150301RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services