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Patent US5904717 - Method and device for reconstruction of articular cartilage - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsA biodegradable device for facilitating healing of structural voids in bone, cartilage as well as soft tissue is disclosed in the most preferred form including a porous macrostructure made from a biodegradable polymer and a chemotactic ground substance in the form of an RGD attachment moiety of fibronectin...http://www.google.com/patents/US5904717?utm_source=gb-gplus-sharePatent US5904717 - Method and device for reconstruction of articular cartilageAdvanced Patent SearchPublication numberUS5904717 APublication typeGrantApplication numberUS 08/370,161Publication dateMay 18, 1999Filing dateJan 9, 1995Priority dateJan 28, 1986Fee statusPaidPublication number08370161, 370161, US 5904717 A, US 5904717A, US-A-5904717, US5904717 A, US5904717AInventorsJohn H. Brekke, Richard D. CouttsOriginal AssigneeThm Biomedical, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (54), Non-Patent Citations (74), Referenced by (40), Classifications (43), Legal Events (8) External Links: USPTO, USPTO Assignment, EspacenetMethod and device for reconstruction of articular cartilageUS 5904717 AAbstract A biodegradable device for facilitating healing of structural voids in bone, cartilage as well as soft tissue is disclosed in the most preferred form including a porous macrostructure made from a biodegradable polymer and a chemotactic ground substance in the form of an RGD attachment moiety of fibronectin formed as a porous microstructure. For repair of articular cartilage, harvested precursor cells are secured to the biodegradable carrier which is shaped for press fitting into the articular cartilage lesion. In the most preferred form, the chemotactic ground substance enhances the attractiveness of the biodegradable device for cellular attachment at the site of repair and also facilitates the attachment of free, precursor cells such as chondrocytes and bone marrow to the biodegradable device. In the most preferred form, biological modifiers such as transforming growth factor B and basic fibroblastic growth factor is incorporated in the biodegradable device to mediate cellular activity and regulate cellular functions.
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