Source: http://www.google.com/patents/US20030229372?dq=2040248
Timestamp: 2016-10-26 23:13:38
Document Index: 136818615

Matched Legal Cases: ['arts 12', 'arts 12', 'arts 12', 'arts 12', 'arts 12', 'arts 12', 'arts 12', 'arts 12', 'art 62', 'art 68', 'art 68', 'arts 62', 'arts 62', 'art 84', 'art 85', 'arts 84']

Patent US20030229372 - Inflatable device for use in surgical protocols relating to treatment of ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA balloon for use in compressing cancellous bone and marrow (also known as medullary bone or trabecular bone) against the inner cortex of bones whether the bones are fractured or not. The balloon comprises an inflatable, non-expandable balloon body for insertion into said bone. The body has a shape and...http://www.google.com/patents/US20030229372?utm_source=gb-gplus-sharePatent US20030229372 - Inflatable device for use in surgical protocols relating to treatment of fractured or diseased boneAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20030229372 A1Publication typeApplicationApplication numberUS 10/458,235Publication dateDec 11, 2003Filing dateJun 10, 2003Priority dateJan 26, 1994Also published asUS20060235460Publication number10458235, 458235, US 2003/0229372 A1, US 2003/229372 A1, US 20030229372 A1, US 20030229372A1, US 2003229372 A1, US 2003229372A1, US-A1-20030229372, US-A1-2003229372, US2003/0229372A1, US2003/229372A1, US20030229372 A1, US20030229372A1, US2003229372 A1, US2003229372A1InventorsMark Reiley, Arie Scholten, Karen TalmadgeOriginal AssigneeKyphon Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (99), Referenced by (94), Classifications (59), Legal Events (6) External Links: USPTO, USPTO Assignment, EspacenetInflatable device for use in surgical protocols relating to treatment of fractured or diseased bone
DESCRIPTION OF THE PREFERRED EMBODIMENT [0089] Balloons for Vertebral Bodies [0090] A first embodiment of the balloon (FIG. 1) of the present invention is broadly denoted by the numeral 10 and includes a balloon body 11 having a pair of hollow, inflatable, non-expandable parts 12 and 14 of flexible material, such as PET or Kevlar. Parts 12 and 14 have a suction tube 16 therebetween for drawing fats and other debris by suction into tube 16 for transfer to a remote disposal location. Catheter 16 has one or more suction holes so that suction may be applied to the open end of tube 16 from a suction source (not shown) The parts 12 and 14 are connected together by an adhesive which can be of any suitable type. Parts 12 and 14 are doughnut-shaped as shown in FIG. 1 and have tubes 18 and 20 which communicate with and extend away from the parts 12 and 14, respectively, to a source of inflating liquid under pressure (not shown). The liquid can be any sterile biocompatible solution. The liquid inflates the balloon 10, particularly parts 12 and 14 thereof after the balloon has been inserted in a collapsed condition (FIG. 8) into a bone to be treated, such as a vertebral bone 22 in FIG. 2. The above-mentioned U.S. Pat. Nos. 4,969,888 and 5,108,404 disclose the use of a guide pin and cannula for inserting the balloon into bone to be treated when the balloon is deflated and has been inserted into a tube and driven by the catheter into the cortical bone where the balloon is inflated. [0091] [0091]FIG. 8 shows a deflated balloon 10 being inserted through a cannula 26 into bone. The balloon in cannula 26 is deflated and is forced through the cannula by exerting manual force on the catheter 21 which extends into a passage 28 extending into the interior of the bone. The catheter is slightly flexible but is sufficiently rigid to allow the balloon to be forced into the interior of the bone where the balloon is then inflated by directing fluid into tube 88 whose outlet ends are coupled to respective parts 12 and 14. [0092] In use, balloon 10 is initially deflated and, after the bone to be filled with the balloon has been prepared to receive the balloon with drilling, the deflated balloon is forced into the bone in a collapsed condition through cannula 26. The bone is shown in FIG. 2. The balloon is oriented preferably in the bone such that it allows minimum pressure to be exerted on the bane marrow and/or cancellous bone if there is no fracture or collapse of the bone. Such pressure will compress the bone marrow and/or cancellous bone against the inner wall of the cortical bone, thereby compacting the bone marrow of the bone to be treated and to further enlarge the cavity in which the bone marrow is to be replaced by a biocompatible, flowable bone material. [0093] The balloon is then inflated to compact the bone marrow and/or cancellous bone in the cavity and, after compaction of the bone marrow and/or cancellous bone, the balloon is deflated and removed from the cavity. While inflation of the balloon and compaction occurs, fats and other debris are sucked out of the space between and around parts 12 and 14 by applying a suction force to catheter tube 16. Following this, and following the compaction of the bone marrow, the balloon is deflated and pulled out of the cavity by applying a manual pulling force to the catheter tube 21. [0094] The second embodiment of the inflatable device of the present invention is broadly denoted by the numeral 60 and is shown in FIGS. 4 and 5. Balloon 60 includes a central spherical part 62 which is hollow and which receives an inflating liquid under pressure through a tube 64. The spherical part is provided with a spherical outer surface 66 and has an outer periphery which is surrounded substantially by a ring shaped part 68 having tube segments 70 for inflation of part 68. A pair of passages 69 interconnect parts 62 and 68. A suction tube segment 72 draws liquid and debris from the bone cavity being formed by the balloon 60. [0095] Provision can be made for a balloon sleeve 71 for balloon 60 and for all balloons disclosed herein. A balloon sleeve 71 (FIG. 9) is shiftably mounted in an outer tube 71 a and can be used to insert the balloon 60 when deflated into a cortical bone. The sleeve 71 has resilient fingers 71 b which bear against the interior of the entrance opening 71 c of the vertebral bone 22 (FIG. 9A) to prevent tearing of the balloon. Upon removal of the balloon sleeve, liquid under pressure will be directed into tube 64 which will inflate parts 62 and 68 so as to compact the bone marrow within the cortical bone. Following this, balloon 60 is deflated and removed from the bone cavity. [0096] [0096]FIGS. 6 and 6A show several views of a modified doughnut shape balloon 80 of the type shown in FIGS. 1 and 2, except the doughnut shapes of balloon 80 are not stitched onto one another. In FIG. 6, balloon 80 has a pear-shaped outer convex surface 82 which is made up of a first hollow part 84 and a second hollow part 85. A tube 88 is provided for directing liquid into the two parts along branches 90 and 92 to inflate the parts after the parts have been inserted into the medullary cavity of a bone. A catheter tube 16 is inserted into the space 96 between two parts of the balloon 80. An adhesive bonds the two parts 84 and 85 together at the interface thereof. [0097] [0097]FIG. 6A shows the way in which the catheter tube 16 is inserted into the space or opening 96 between the two parts of the balloon 80. [0098] [0098]FIG. 7 shows tube 88 of which, after directing inflating liquid into the balloon 80, can inject contrast material into the balloon 80 so that x-rays can be taken of the balloon with the inflating material therewithin to determine the proper placement of the balloon. Tube 16 is also shown in FIG. 6, it being attached in some suitable manner to the outer side wall surface of tube 88. [0099] Still another embodiment of the invention is shown in FIG. 3 which is similar to FIG. 1 except that it is round and not a doughnut and includes an inflatable device 109 having three balloon units 110, 112 and 114 which are inflatable and which have string-like restraints 117 which limit the expansion of the balloon units in a direction transverse to the longitudinal axes of the balloon units. The restraints are made of the same or similar material as that of the balloon so that they have some resilience but substantially no expansion capability. [0100] A tube system 115 is provided to direct liquid under pressure into balloon units 110, 112 and 114 so that liquid can be used to inflate the balloon units when placed inside the bone in a deflated state. Following the proper inflation and compaction of the bone marrow, the balloon can be removed by deflating it and pulling it outwardly of the bone being treated. The restraints keep the opposed sides 77 and 79 substantially flat and parallel with each other. [0101] In FIG. 10, another embodiment of the inflatable balloon is shown. The device is a kidney shaped balloon body 130 having a pair of opposed kidney shaped side walls 132 which are adapted to be collapsed and to cooperate with a continuous end wall 134 so that the balloon 130 can be forced into a bone 136 shown in FIG. 11. A tube 138 is used to direct inflating liquid into the balloon to inflate the balloon and cause it to assume the dimensions and location shown vertebral body 136 in FIG. 11. Device 130 will compress the cancellous bone if there is no fracture or collapse of the cancellous bone. The restraints for this action are due to the side and end walls of the balloon. [0102] [0102]FIG. 12 shows a balloon 140 which is also kidney shaped and has a tube 142 for directing an inflatable liquid into the tube for inflating the balloon. The balloon is initially a single chamber bladder but the bladder can be branded along curved lines or strips 141 to form attachment lines 144 which take the shape of side-by-side compartments 146 which are kidney shaped as shown in FIG. 13. A similar pattern of strips as in 140 but in straight lines would be applied to a balloon that is square or rectangular. The branding causes a welding of the two sides of the bladder to occur since the material is standard medical balloon material, which is similar to plastic and can be formed by heat. [0103] [0103]FIG. 14 is a perspective view of a vertebral body 147 containing the balloon of FIG. 12, showing a double stacked balloon 140 when it is inserted in vertebral bone 147. [0104] [0104]FIG. 15 is a view similar to FIG. 10 except that tufts 155, which are string-like restraints, extend between and are connected to the side walls 152 of inflatable device 150 and limit the expansion of the side walls with respect to each other, thus rendering the side walls generally parallel with each other. Tube 88 is used to fill the kidney shaped balloon with an inflating liquid in the manner described above. [0105] The dimensions for the vertebral body balloon will vary across a broad range. The heights (H, FIG. 11) of the vertebral body balloon for both lumbar and thoracic vertebral bodies typically range from 0.5 cm to 3.5 cm. The anterior to posterior (A, FIG. 11) vertebral body balloon dimensions for both lumbar and thoracic vertebral bodies range from 0.5 cm to 3.5 cm. The side to side (L, FIG. 11) vertebral body dimensions for thoracic vertebral bodies will range from 0.5 cm to 3.5 cm. The side to side vertebral body dimensions for lumbar vertebral bodies will range from 0.5 cm to 5.0 cm. An optimal vertebral body balloon is stacked with two or more members of unequal height where each member can be separately inflated through independent tube systems. The total height of the stack when fully inflated should be within the height ranges specified above. Such a design allows the fractured vertebral body to be returned to its original height in steps, which can be easier on the surrounding tissue, and it also allows the same balloon to be used in a wider range of vertebral body sizes. [0106] The eventual selection of the appropriate balloon for, for instance, a given vertebral body is based upon several factors. The anterior-posterior (A-P) balloon dimension for a given vertebral body is selected from the CT scan or plain film x-ray views of the vertebral body. The A-P dimension is measured from the internal cortical wall of the anterior cortex to the internal cortical wall of the posterior cortex of the vertebral body. In general, the appropriate A-P balloon dimension is 5 to 7 millimeters less than this measurement. [0107] The appropriate side to side balloon dimensions for a given vertebral body is selected from the CT scan or from a plain film x-ray view of the vertebral body to be treated. The side to side distance is measured from the internal cortical walls of the side of the vertebral bone. In general, the appropriate side to side balloon dimension is 5 to 7 millimeters less than this measurement by the addition of the lumbar vertebral body tends to be much wider than side to side dimension then their A-P dimension. In thoracic vertebral bodies, the side to side dimension and their A-P dimensions are almost equal. [0108] The height dimensions of the appropriate vertebral body balloon for a given vertebral body is chosen by the CT scan or x-ray views of the vertebral bodies above and below the vertebral body to be treated. The height of the vertebral bodies above and below the vertebral body to be treated are measured and averaged. This average is used to determine the appropriate height dimension of the chosen vertebral body balloon. [0109] Balloons for Long Bones [0110] Long bones which can be treated with the use of balloons of the present invention include distal radius (larger arm bone at the wrist), proximal tibial plateau (leg bone just below the knee), proximal humerus (upper end of the arm at the shoulder), and proximal femoral head (leg bone in the hip). [0111] Distal Radius Balloon [0112] For the distal radius, a balloon 160 is shown in the distal radius 152 and the balloon has a shape which approximates a pyramid but more closely can be considered the shape of a humpbacked banana in that it substantially fills the interior of the space of the distal radius to force cancellous bone 154 lightly against the inner surface 156 of cortical bone 158. [0113] The balloon 160 has a lower, conical portion 159 which extends downwardly into the hollow space of the distal radius 152, and this conical portion 159 increases in cross section as a central distal portion 161 is approached. The cross section of the balloon 160 is shown at a central location (FIG. 17B) and this location is near the widest location of the balloon. The upper end of the balloon, denoted by the numeral 162, converges to the catheter 88 for directing a liquid into the balloon for inflating the same to force the cancellous bone against the inner surface of the cortical bone. The shape of the balloon 160 is determined and restrained by tufts formed by string restraints 165. These restraints are optional and provide additional strength to the balloon body 160, but are not required to achieve the desired configuration. The balloon is placed into and taken out of the distal radius in the same manner as that described above with respect to the vertebral bone. [0114] The dimensions of the distal radius balloon vary as follows: [0115] The proximal end of the balloon (i.e. the part nearest the elbow) is cylindrical in shape and will vary from 0.5�0.5 cm to 1.8�1.8 cm. [0116] The length of the distal radius balloon will vary from 1.0 cm to 12.0 cm. [0117] The widest medial to lateral dimension of the distal radius balloon, which occurs at or near the distal radio-ulnar joint, will measure from 1.0 cm to 2.5 cm. [0118] The distal anterior-posterior dimension of the distal radius balloon will vary from 0.5 to 3.0 cm. [0119] Proximal Humerus Fracture Balloon [0120] The selection of the appropriate balloon size to treat a given fracture of the distal radius will depend on the radiological size of the distal radius and the location of the fracture. [0121] In the case of the proximal humerus 169, a balloon 166 shown in FIG. 18 is spherical and has a base design. It compacts the cancellous bone 168 in a proximal humerus 169. A mesh 170, embedded or laminated and/or winding, may be used to form a neck 172 on the balloon 166, and second mesh 170 a may be used to conform the bottom of the base 172 a to the shape of the inner cortical wall at the start of the shaft. These restraints provide additional strength to the balloon body, but the configuration can be achieved through molding of the balloon body. This is so that the cancellous bone will be as shown in the compacted region surrounding the balloon 166 as shown in FIG. 18. The cortical bone 173 is relatively wide at the base 174 and is thin-walled at the upper end 175. The balloon 166 has a feed tube 177 into which liquid under pressure is forced into the balloon to inflate it to lightly compact the cancellous bone in the proximal humerus. The balloon is inserted into and taken out of the proximal humerus in the same manner as that described above with respect to the vertebral bone. [0122] The dimensions of the proximal humerus fracture balloon vary as follows: [0123] The spherical end of the balloon will vary from 1.0�1.0 cm to 3.0�3.0 cm. [0124] The neck of the proximal humeral fracture balloon will vary from 0.8�0.8 cm to 3.0�3.0 cm. [0125] The width of the base portion or distal portion of the proximal numeral fracture balloon will vary from 0.5�0.5 cm to 2.5�2.5 cm. [0126] The length of the balloon will vary from 4.0 cm to 14.0 cm. [0127] The selection of the appropriate balloon to treat a given proximal humeral fracture depends on the radiologic size of the proximal humerus and the location of the fracture. [0128] Proximal Tibial Plateau Fracture Balloon [0129] The tibial fracture is shown in FIG. 19A in which a balloon 180 is placed in one side 182 of a tibia 183. [0130] The balloon, when inflated, compacts the cancellous bone in the layer 184 surrounding the balloon 180. A cross section of the balloon is shown in FIG. 19C wherein the balloon has a pair of opposed sides 185 and 187 which are interconnected by restraints 188 which can be in the form of strings or flexible members of any suitable construction. The main purpose of the restraints is to make the sides 185 and 187 substantially parallel with each other and non-spherical. A tube 190 is coupled to the balloon 180 to direct liquid into and out of the balloon. The ends of the restraints are shown in FIGS. 19B and 19D and denoted by the numeral 191. The balloon is inserted into and taken out of the tibia in the same manner as that described above with respect to the vertebral bone. FIG. 19B shows a substantially circular configuration for the balloon; whereas, FIG. 19D shows a substantially elliptical version of the balloon. [0131] The dimensions of the proximal tibial plateau fracture balloon vary as follows: [0132] The thickness or height of the balloon will vary from 0.5 cm to 5.0 cm. [0133] The anterior/posterior (front to back) dimension will vary from 1.0 cm to 6.0 cm. [0134] The side to side (medial to lateral) dimension will vary from 1.0 cm to 6.0 cm. [0135] The selection of the appropriate balloon to treat a given tibial plateau fracture will depend on the radiological size of the proximal tibial and the location of the fracture. [0136] Femoral Head Balloon [0137] In the case of the femoral head, a balloon 200 is shown as having been inserted inside the cortical bone 202 of the femoral head which is thin at the outer end 204 of the femur and which can increase in thickness at the lower end 206 of the femur. The cortical bone surrounds the cancellous bone 207 and this bone is compacted by the inflation of balloon 200. The tube for directing liquid for inflation purposes into the balloon is denoted by the numeral 209. It extends along the femoral neck and is directed into the femoral head which is generally spherical in configuration. FIG. 20A shows that the balloon, denoted by the numeral 200 a, can be hemispherical as well as spherical, as shown in FIG. 20. The balloon 200 is inserted into and taken out of the femoral head in the same manner as that described with respect to the vertebral bone. The hemispherical shape is maintained in this example by bonding overlapping portions of the bottom, creating pleats 200 b as shown in FIG. 20A. [0138] The dimensions of the femoral head balloon vary as follows: [0139] The diameter of the femoral head balloon will vary from 1.0 cm to up to 4.5 cm. The appropriate size of the femoral head balloon to be chosen depends on the radiological or CT scan size of the head of the femur and the location and size of the avascular necrotic bone. The dimensions of the hemispherical balloon are the same as the those of the spherical balloon, except that approximately one half is provided. [0140] Other Uses, Methods and Balloons [0141] To deliver therapeutic substances, balloons can be dipped in a medical formulation (often a dry powder, liquid or gel) containing a medically effective amount of any desired antibiotic, bone growth factor or other therapeutic agent to coat the balloon with the above-mentioned substance before it is inserted into a bone being treated. Optionally, the balloon can be wholly or partially inflated with air or liquid before the coating is performed. Optionally, the coated balloon can be dried with air or by other means when the applied formulation is wet, such as a liquid or a gel. The balloon is refolded as required and either used immediately or stored, if appropriate and desired. Coated on the balloon, therapeutic substances can be delivered while cancellous bone is being compressed, or with an additional balloon once the cavity is made. [0142] The methods described above can also be used to coat Gelfoam or other agents onto the balloon before use. Inflating the Gelfoam-coated balloon inside bone will further fill any cracks in fractured bone not already filled by the compressed cancellous bone. [0143] Medically effective amounts of therapeutic substances are defined by their manufacturers or sponsors and are generally in the range of 10 nanograms to 50 milligrams per site, although more or less may be required in a specific case. Typical antibiotics include gentamicin and tobramycin. Typical bone growth factors are members of the Bone Morphogenetic Factor, Osteogenic Protein, Fibroblast Growth Factor, Insulin-Like Growth Factor and Transforming Growth Factor alpha and beta families. [0144] The balloons described in this invention can be used in open surgical procedures at the sites discussed above to provide an improved space for inserting orthopedic implants, bone graft, bone substitutes, bone fillers or therapeutic substances. The size and shape of balloon chosen would be determined by the site being treated and then by the size, shape or amount of material that the surgeon wants to insert into the remaining bone. Square and rectangular balloons can be used at any site for the placement of bone substitutes like hydroxyapatites which are available in those shapes. Balloons would be made to match those predetermined sizes, and the surgeon would chose the balloon to fit the size of material chosen. [0145] Different sizes and/or shapes of balloons may be used at sites not specified above, such as the jaw bones or the midshaft of the arm and leg bones. However, useful balloons can be designed by the principles of the inventions herein. The shape of the cancellous bone to be compressed, and the local structures that could be harmed if bone were moved inappropriately, are generally understood by medical professionals using textbooks of human skeletal anatomy along with their knowledge of the site and its disease or injury. Ranges of shapes and dimensions are defined by the site to be treated. Precise dimensions for a given patient are determined by X-ray of the site to be treated, the therapeutic goal and safety constraints at the site. For diseased bone, replacement of the most of the cancellous bone is usually desired, so a balloon whose shape and size will compress around 70-90% of the volume of the cancellous bone in the treated region will be chosen. However, balloons that are smaller or larger may be appropriate, particularly where delivery of a therapeutic substance is the main goal. There, the balloon size could be chosen by the desired amount of therapeutic substance, keeping in mind local structures and safety when the balloon is fully inflated. 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A61F2/389, A61M25/10, A61F2002/30686, A61F2002/2871, A61F2230/0015, A61F2/3601, A61F2/4601, A61F2002/30133, A61F2002/2828, A61F2002/30581, A61F2002/30677, A61F2002/2832, A61M2210/1003, A61F2002/30586, A61F2002/30242, A61B2017/0256, A61F2230/0071, A61F2002/30599, A61F2250/0063, A61F2230/0013, A61B17/7258, A61F2230/0069, A61F2002/30228, A61M25/1011, A61F2002/4602, A61F2002/2853, A61B2017/00557, A61F2002/30225, A61F2002/4062, A61F2002/2892, A61M2025/1072, A61F2002/30131, A61M25/1002European ClassificationA61B17/88C2B, A61B17/72E6, A61M25/10A, A61M25/10, A61F2/46ALegal EventsDateCodeEventDescriptionFeb 5, 2007ASAssignmentOwner name: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT, WAFree format text: SECURITY AGREEMENT;ASSIGNOR:KYPHON INC.;REEL/FRAME:018875/0574Effective date: 20070118Owner name: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT,WASFree format text: SECURITY AGREEMENT;ASSIGNOR:KYPHON INC.;REEL/FRAME:018875/0574Effective date: 20070118Apr 27, 2007ASAssignmentOwner name: KYPHON 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MEDTRONIC SPINE LLC,CALIFORNIAFree format text: CHANGE OF NAME;ASSIGNOR:KYPHON INC;REEL/FRAME:020993/0042Effective date: 20080118Jun 9, 2008ASAssignmentOwner name: KYPHON SARL, SWITZERLANDFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MEDTRONIC SPINE LLC;REEL/FRAME:021070/0278Effective date: 20080325Owner name: KYPHON SARL,SWITZERLANDFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MEDTRONIC SPINE LLC;REEL/FRAME:021070/0278Effective date: 20080325Mar 26, 2015ASAssignmentOwner name: ORTHOPHOENIX, LLC, TEXASFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KYPHON SARL;REEL/FRAME:035307/0018Effective date: 20130425RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services