Source: http://www.science.gov/topicpages/a/act+tsca+exist.html
Timestamp: 2016-10-25 17:38:10
Document Index: 117579057

Matched Legal Cases: ['§ 799', '§ 799', 'arts 704', 'art 792', '§ 799', 'art 792', '§ 799', 'art 792', '§ 799', 'art 792', '§ 799', 'art 792', 'art 792', 'art 792', 'art 792', 'art 792', 'art 792', 'ART 710', '§ 799', 'art 792', 'art 792', 'art 792', 'arts 704', '§ 11', '§ 2640', '§ 220', '§ 301', '§ 301', '§ 11', '§ 301', '§ 200', '§ 200', '§ 200', 'art 1212', 'art 1212', '§ 1955', '§ 17', '§ 17', '§ 17', '§ 17']

act tsca exist: Topics by Science.gov
Sample records for act tsca exist
8(E) TRIAGE CHEMICAL STUDIES DATABASE (TSCA)
The Toxic Substances Control Act (TSCA) gives the Environmental Protection Agency (EPA) the authority and responsibility to identify and control chemical hazards to human health or the environment. TSCA gives the EPA authority to gather certain kinds of basic information on chemi...
78 FR 64936 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Rescheduled...
... AGENCY Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Rescheduled... regarding EPA's draft Toxic Substances Control Act (TSCA) chemical risk assessment, ``TSCA Workplan Chemical Risk Assessment for Dichloromethane and N-Methylpyrrolidone.'' The first meeting was held as...
78 FR 67141 - Antimony Trioxide (ATO) TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity...
... AGENCY Antimony Trioxide (ATO) TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity... Substances Control Act (TSCA) chemical risk assessment, ``TSCA Workplan Chemical Risk Assessment for ATO... CONTACT: For technical information contact: Stan Barone, Jr., Risk Assessment Division (7403M), Office...
Reauthorization of Toxic Substances Control Act for fiscal year 1984. Hearing before the Subcommittee on Commerce, Transportation, and Tourism of the Committee on Energy and Commerce, House of Representatives, Ninety-Eighth Congress, First Session, April 21, 1983
A hearing to reauthorize the Toxic Substances Control Act (TSCA) reviewed evidence that few new chemicals introduced into the consumer market are tested for toxicity and that no testing rules have been issued in the seven years of TSCA's existence in contrast to the testing record of some European countries. The 13 witnesses represented the Chamber of Commerce, conservation and environmental groups and agencies, and manufacturers of potentially toxic materials. The latter cited the economic burden on small businesses and the constraints on innovation that TSCA has had. Others stressed potential health hazards from untested materials and the poor record of TSCA implementation. (DCK)
... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA bacterial reverse mutation test. 799.9510 Section 799.9510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines...
Rosenthal, I; Jayjock, M A; Keener, R L; Plamondon, J E
The Toxic Substances Control Act (TSCA) authorizes the EPA to take appropriate actions to ensure that new and existing chemicals do not pose "unreasonable risk" to health or the environment. Section 2(b)(3) of the Act directs the Agency to accomplish this objective in a manner that does "not impede unduly or create unnecessary economic barriers to technological innovation." In recent years, critics have felt that the EPA has failed to achieve these primary goals of TSCA. This paper considers some of the reasons for this criticism and advocates an alternate approach of exposure limits and operationally sufficient controls to assist in achieving these goals. An illustration of how this alternate approach might work under practical conditions is presented, using as an example a new chemical substance from the class of acrylate monomers. These concepts and risk assessments provide data for a better design of future studies according to good laboratory practice and quality assurance. PMID:1669965
40 CFR 799.9530 - TSCA in vitro mammalian cell gene mutation test.
... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA in vitro mammalian cell gene mutation test. 799.9530 Section 799.9530 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS Health Effects...
40 CFR 799.9135 - TSCA acute inhalation toxicity with histopathology.
... Substances Control Act (TSCA). In the assessment and evaluation of the potential human health effects of..., brain, and gonads shall be weighed wet, as soon as possible after dissection to avoid drying. (iii) The... possible future histopathological examination: All gross lesions; brain-including sections of...
...In accordance with the requirements of the Privacy Act of 1974, HRSA is deleting an existing system of records titled Record of Patient's Personal Valuables and Monies, HRSA SOR 09-15-0002, established at Vol. 59, No. 61 Federal Register pp 6854-6, December 28,...
76 FR 32997 - Privacy Act of 1974: Update Existing System of Records
...The U.S. Office of Personnel Management (OPM) proposes to update OPM/GOVT-1, General Personnel Records, System of Records. This action is necessary to meet the requirements of the Privacy Act to publish in the Federal Register notice of the existence and character of records maintained by the agency (5 U.S.C. 552a(e)(4) and...
... 40 Protection of Environment 33 2012-07-01 2012-07-01 false TSCA neurotoxicity screening battery... REQUIREMENTS Health Effects Test Guidelines § 799.9620 TSCA neurotoxicity screening battery. (a) Scope. This... battery consists of a functional observational battery, motor activity, and neuropathology. The...
... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA neurotoxicity screening battery... REQUIREMENTS Health Effects Test Guidelines § 799.9620 TSCA neurotoxicity screening battery. (a) Scope. This... battery consists of a functional observational battery, motor activity, and neuropathology. The...
75 FR 49655 - TSCA Inventory Update Reporting Modifications
... Protection Agency 40 CFR Parts 704, 710, and 711 TSCA Inventory Update Reporting Modifications; Proposed Rule... Modifications AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: The Toxic... Business Information (CBI) reporting procedures. These modifications would provide information to...
77 FR 30855 - Sixty-Ninth Report of the TSCA Interagency Testing Committee to the Administrator of the...
...The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 69th Report to the EPA Administrator on April 5, 2012. In the 69th ITC Report, which is included with this notice, the ITC is adding a category of cadmium compounds including any chemical that contains cadmium as part of that chemical's structure, 6 non-phthalate plasticizers, 25 phosphate ester flame......
78 FR 52525 - Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Public Meetings...
... notice in the Federal Register (78 FR 1856) (FRL-9375-1) on the availability of five draft TSCA chemical... AGENCY Dichloromethane and N-Methylpyrrolidone TSCA Chemical Risk Assessment; Notice of Public Meetings... assessment, ``TSCA Workplan Chemical Risk Assessment for Dichloromethane and N-Methylpyrrolidone.'' EPA...
...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards... 40 Protection of Environment 32 2011-07-01 2011-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA...
...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA...
...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards... 40 Protection of Environment 31 2010-07-01 2010-07-01 true TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA...
...) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA reproduction/developmental... AND MIXTURE TESTING REQUIREMENTS Health Effects Test Guidelines § 799.9355 TSCA...
40 CFR 799.9410 - TSCA chronic toxicity.
... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... aminotransferase, alkaline phosphatase, sorbitol dehydrogenase, or gamma glutamyl transpeptidase) should also be... requirements specified under EPA Good Laboratory Practice Standards at 40 CFR part 792, subpart J,...
40 CFR 799.9130 - TSCA acute inhalation toxicity.
...) Definitions. The definitions in section 3 of TSCA and the definitions in 40 CFR Part 792—Good Laboratory... 40 CFR part 792, subpart f. (3) Test procedures—(i) Preparation. Healthy young adult animals are... at 40 CFR part 792, subpart J, the following specific information must be reported. The test...
... morphological (pathological) effects. (c) Definitions. The definitions in section 3 of TSCA and in 40 CFR Part... requirements specified under EPA Good Laboratory Practice Standards at 40 CFR part 792, subpart J, the... equipment. The study must be conducted in compliance with 40 CFR Part 792—Good Laboratory Practice...
77 FR 62059 - Privacy Act of 1974, as Amended; Revisions to Existing Systems of Records
... Affairs Phone Log NTSB-21 Respiratory Protection Program Records NTSB-22 Occupational Health and Safety... between NTSB-5 and OGE/GOVT-2. OGE/GOVT-2 is available at 68 FR 3098 (Jan. 22, 2003), as updated at 68 FR... Existing Systems of Records; Notice #0;#0;Federal Register / Vol. 77 , No. 197 / Thursday, October 11,...
Design of a computerized chemical information file in response to the initial inventory requirements of TSCA.
Vogt, H C; Kerfoot, E J; Ford, G J
A computerized file of chemical information, "CHEMFO", was developed at BASF Wyandotte Corporation to help comply with the initial reporting requirements of the Toxic Substances Control Act. This organization and approach allowed collecting the required information on all the manufactured and imported chemicals, editing and entry of the data, structuring of the computer file and interactive capabilities, and selecting the final program and subsequent printout. Besides using this system to meet the TSCA initial inventory reporting requirements, the file also has the capacity to be updated and revised as needed, which further expands its potential benefits. Some of the other information that can be derived from this system are: identification of chemical substances, quantities, and each site; tie-in to the medical/occupational health data bank; foundation for recording the industrial hygiene monitoring data; supplement for toxicology and environmental data base; and index for generating compilation of site specific material on health and environmental information. PMID:7457385
76 FR 54932 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting
...; Chemical Data Reporting Correction In rule document 2011-19922, appearing on pages 50816-50879 in the issue...)(ii) of the definition importer. ] PART 710--COMPILATION OF THE TSCA CHEMICAL SUBSTANCE INVENTORY 0 3.... * * * * * (b) This part applies to the activities associated with the compilation of the TSCA...
... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA water solubility: Column elution... AND MIXTURE TESTING REQUIREMENTS Product Properties Test Guidelines § 799.6784 TSCA water solubility... here may not yet be optimal. This method is intended for material with solubilities below...
Stabilization/solidification of TSCA incinerator ash
Spence, R.D.; Trotter, D.R.; Francis, C.L.; Morgan, I.L.
Stabilization/solidification is a well-known waste treatment technique that utilizes different additives and processes. The Phoenix Ash Technology of the Technical Innovation Development Engineering Company is such a technique that uses Cass C fly ash and mechanical pressure to make brick waste forms out of solid wastes, such as the bottom ash from the Toxic Substances Control Act incinerator at the Oak Ridge K-25 Site. One advantage of this technique is that no volume increase over the bulk volume of the bottom ash occurs. This technique should have the same high pH stabilization for Resource Conservation and Recovery Act metals as similar techniques. Also, consolidation of the bottom ash minimizes the potential problems of material dispersion and container corrosion. The bottom ash was spiked with {sup 99}{Tc} to test the effectiveness of the bricks as a physical barrier. The {sup 99}{Tc} leachability index measured for these bricks was 6.8, typical for the pertechnetate anion in cementitious waste forms, indicating that these bricks have accessible porosity as high as that of other cementitious waste forms, despite the mechanical compression, higher waste form density, and water resistant polymer coating.
... section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, and...
40 CFR 799.9537 - TSCA in vitro mammalian chromosome aberration test.
.... The definitions in section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply... after an S period of DNA replication, the nucleus does not go into mitosis but starts another S...
24 CFR 1000.210 - What happens to existing 1937 Act units in those jurisdictions for which Indian tribes do not or...
... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false What happens to existing 1937 Act units in those jurisdictions for which Indian tribes do not or cannot submit an IHP? 1000.210 Section 1000.210 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC...
77 FR 1728 - Privacy Act of 1974; Publication of Five New Systems of Records; Amendments to Five Existing...
... February 6, 2003, at 68 FR 6185, a new system of records was published on behalf of the Office of the 21st... Workforce. On September 15, 2003, at volume 68 FR 54012, the Department amended two existing systems of... before a court or adjudicative body, when: (a) The agency or any component thereof; or (b) any...
... section 3 of TSCA and in 40 CFR Part 792—Good Laboratory Practice Standards apply to this section. The... concentration, erythrocyte count, total and differential leukocyte count, platelet count and a measure of blood clotting time/potential. (ii) Blood samples should be taken from a named site just prior to or as part...
76 FR 50815 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting
... Update Reporting Modifications; Chemical Data Reporting; Final Rule #0;#0;Federal Register / Vol. 76 , No... Parts 704, 710, and 711 RIN 2070-AJ43 TSCA Inventory Update Reporting Modifications; Chemical Data... definitional modifications and additions. 3. EPA is amending 40 CFR 710.53, which appears in the new 40...
75 FR 58377 - Lead in Ammunition and Fishing Sinkers; Disposition of TSCA Section 21 Petition
... AGENCY Lead in Ammunition and Fishing Sinkers; Disposition of TSCA Section 21 Petition AGENCY... section 6(a) the manufacture, processing, and distribution in commerce of (1) lead bullets and shot; and (2) lead fishing sinkers. On August 27, 2010, EPA denied the first request due to a lack of...
75 FR 70246 - Lead Fishing Sinkers; Disposition of TSCA Section 21 Petition
... Lead in Bullets and Shot As discussed in the Federal Register of September 24, 2010 (75 FR 58377) (FRL... one the Agency, as reflected in its proposal, found to be appropriate even then. (59 FR 11122, March 9... AGENCY Lead Fishing Sinkers; Disposition of TSCA Section 21 Petition AGENCY: Environmental...
78 FR 34377 - Trichloroethylene TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity to...
... Risk Assessment for Trichloroethylene: Degreaser and Arts/Crafts Uses.'' EPA will hold three peer..., including one entitled, ``TSCA Workplan Chemical Risk Assessment for Trichloroethylene: Degreaser and Arts/Crafts Uses.'' Trichloroethylene (TCE) (CASRN 79-01-6) is one of 83 chemicals identified for review...
75 FR 8266 - Final Clarification for Chemical Identification Describing Activated Phosphors for TSCA Inventory...
... in the Federal Register issue of January 16, 2008 (73 FR 2854) (FRL-8131-8) and a reopening of comments on the proposed clarification was announced in the Federal Register issue of May 2, 2008 (73 FR... Federal Register issue of December 23, 1977 (42 FR 64572) under TSCA section 8(a), 15 U.S.C. 2607(a),...
... 40 Protection of Environment 33 2013-07-01 2013-07-01 false TSCA water solubility: Generator...: Generator column method. (a) Scope—(1) Applicability. This section is intended to meet the testing... the saturated solutions produced by the generator column. After extraction onto a...
... 40 Protection of Environment 32 2014-07-01 2014-07-01 false TSCA water solubility: Generator...: Generator column method. (a) Scope—(1) Applicability. This section is intended to meet the testing... the saturated solutions produced by the generator column. After extraction onto a...
THOMAS, 113th Congress Rep. Rangel, Charles B. [D-NY-13
... Regulatory Review'' (76 FR 3821, January 21, 2011). EPA has prepared an economic analysis of this action.... EPA. Electronic Toxic Control Act (eTSCA)/e-PMN Reporting Tool User's Guide. 7. EPA. Economic Analysis... submitters would ultimately exceed the transition costs (see Economic Analysis referenced in Unit IV.)....
[Calculating personnel allocation at 100 % implementation of the Psychiatry Personnel Act. Can it be done on the basis of existing routine data?].
Godemann, F; Wolff-Menzler, C; Löhr, M; Nitschke, R; Salize, H J; Seemüller, F; Laengle, G; Wolff, J; Hauth, I
From 1 January 2019, after completion of the convergence phase, the Psychiatry Personnel Act (Psych-PV) will no longer be the basis of budget negotiations of psychiatric hospitals and departments with the health insurance funds in Germany. Instead, the new compounding remuneration system for psychiatric and psychosomatic inpatient institutions (PEPP) will provide a new framework. The Federal Joint Committee (Gemeinsamer Bundesausschuss, G-BA) has been given the task of elaborating a directive on the basis of the expiring Psych-PV in order to redefine standards for personnel allocation within this new framework. This task presupposes the existence of reliable data in the psychiatric hospitals and departments for categorizing patients following the Psych-PV. It presupposes further that these data allow an exact calculation of the personnel to which the clinics are entitled. This article shows that the so-called §-21 dataset from the database of the VIPP project (indicators of patient care in psychiatric and psychosomatic facilities) allows this calculation. The VIPP dataset was used as a basis to calculate the personnel requirements. Exemplary analyses illustrate that the information available regarding the Psych-PV can be transformed in minutes per day, minutes per month and full time positions. Therefore, this information would also be available to the Institute for the Hospital Remuneration System (InEK). PMID:26099500
75 FR 42441 - Sixty-Sixth Report of the TSCA Interagency Testing Committee to the Administrator of the...
... Federal Register issue of February 25, 2010 (75 FR 8575) (FRL-8805-8) available on-line at http://www.gpoaccess.gov/fr . III. The TSCA Interagency Testing Committee Statutory Organizations and Their... Recommended (mixed isomers) 41 November 1997 Phenol, 4-(1,1,3,3- Recommended tetramethylbutyl)- 55...
Indian Child Welfare Act: Existing Information on Implementation Issues Could Be Used to Target Guidance and Assistance to States. GAO-05-290
US Government Accountability Office, 2005
The Indian Child Welfare Act (ICWA ) created important protections to prevent state child welfare agencies and courts from inappropriately separating American Indian children from their families. This report describes (1) the factors that influence placement decisions for children subject to ICWA; (2) the extent to which, if any, placements for…
Mode of action and the assessment of chemical hazards in the presence of limited data: use of structure-activity relationships (SAR) under TSCA, Section 5.
Auer, C M; Nabholz, J V; Baetcke, K P
Section 5 of the Toxic Substances Control Act (TSCA) requires that manufacturers and importers of new chemicals must submit a Premanufacture Notification (PMN) to the U.S. Environmental Protection Agency 90 days before they intend to commence manufacture or import. Certain information such as chemical identity, uses, etc., must be included in the notification. The submission of test data on the new substance, however, is not required, although any available health and environmental information must be provided. Nonetheless, over half of all PMNs submitted to the agency do not contain any test data; because PMN chemicals are new, no test data is generally available in the scientific literature. Given this situation, EPA has had to develop techniques for hazard assessment that can be used in the presence of limited test data. EPA's approach has been termed "structure-activity relationships" (SAR) and involves three major components: the first is critical evaluation and interpretation of available toxicity data on the chemical; the second component involves evaluation of test data available on analogous substances and/or potential metabolites; and the third component involves the use of mathematical expressions for biological activity known as "quantitative structure-activity relationships" (QSARs). At present, the use of QSARs is limited to estimating physical chemical properties, environmental toxicity, and bioconcentration factors. An important overarching element in EPA's approach is the experience and judgment of scientific assessors in interpreting and integrating the available data and information. Examples are provided that illustrate EPA's approach to hazard assessment for PMN chemicals. PMID:2269224
Chayama, Kazuaki; Hayes, C. Nelson
Sustained virological response (SVR) rates have increased dramatically following the approval of direct acting antiviral (DAA) therapies. While individual DAAs have a low barrier to resistance, most patients can be successfully treated using DAA combination therapy. However, DAAs are vulnerable to drug resistance, and resistance-associated variants (RAVs) may occur naturally prior to DAA therapy or may emerge following drug exposure. While most RAVs are quickly lost in the absence of DAAs, compensatory mutations may reinforce fitness. However, the presence of RAVs does not necessarily preclude successful treatment. Although developments in hepatitis C virus (HCV) therapy in Asia have largely paralleled those in the United States, Japan’s July 2014 approval of asunaprevir plus daclatasvir combination therapy as the first all-oral interferon-free therapy was not repeated in the United States. Instead, two different combination therapies were approved: sofosbuvir/ledipasvir and paritaprevir/ritonavir/ombitasvir/dasabuvir. This divergence in treatment approaches may lead to differences in resistance challenges faced by Japan and the US. However, the recent approval of sofosbuvir plus ledipasvir in Japan and the recent submissions of petitions for approval of paritaprevir/ritonavir plus ombitasvir suggest a trend towards a new consensus on emerging DAA regimens. PMID:26473914
Chen, Zhi-Wei; Li, Hu; Ren, Hong; Hu, Peng
Direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) proteins open a whole new era for anti-HCV therapy, but DAA resistance associated variants (RAVs) could jeopardize the effectiveness of DAAs. We reported the global prevalence of DAA RAVs using published GenBank data. 58.7% of sequences (854/1455) harbored at least one dominant resistance variant and the highest RAV frequency occurred in Asia (74.1%), followed by Africa (71.9%), America (53.5%) and Europe (51.4%). The highest RAV frequency was observed in genotype (GT) 6 sequences (99%), followed by GT2 (87.9%), GT4 (85.5%), GT1a (56%), GT3 (50.0%) and GT1b (34.3%). Furthermore, 40.0% and 29.6% of sequences were detected RAVs of non-structural (NS) 5A inhibitors and NS3 protease inhibitors, respectively. However, RAVs to NS5B nucleo(t)ide inhibitor (NI) and NI-based combinations were uncommon (<4% of sequences). As expected, combinations of multiple RAVs to the IFN-free regimens recommended by current guidelines were rarely detected (0.2%-2.0%). Our results showed that the overall global prevalence of DAA RAVs was high irrespective of geography or genotype. However, the NI-based multi-DAA regimens had a low RAV prevalence, suggesting that these regimens are the most promising strategies for cure of the long-term HCV infection. PMID:26842909
Direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) proteins open a whole new era for anti-HCV therapy, but DAA resistance associated variants (RAVs) could jeopardize the effectiveness of DAAs. We reported the global prevalence of DAA RAVs using published GenBank data. 58.7% of sequences (854/1455) harbored at least one dominant resistance variant and the highest RAV frequency occurred in Asia (74.1%), followed by Africa (71.9%), America (53.5%) and Europe (51.4%). The highest RAV frequency was observed in genotype (GT) 6 sequences (99%), followed by GT2 (87.9%), GT4 (85.5%), GT1a (56%), GT3 (50.0%) and GT1b (34.3%). Furthermore, 40.0% and 29.6% of sequences were detected RAVs of non-structural (NS) 5A inhibitors and NS3 protease inhibitors, respectively. However, RAVs to NS5B nucleo(t)ide inhibitor (NI) and NI-based combinations were uncommon (<4% of sequences). As expected, combinations of multiple RAVs to the IFN-free regimens recommended by current guidelines were rarely detected (0.2%–2.0%). Our results showed that the overall global prevalence of DAA RAVs was high irrespective of geography or genotype. However, the NI-based multi-DAA regimens had a low RAV prevalence, suggesting that these regimens are the most promising strategies for cure of the long-term HCV infection. PMID:26842909
Existence of Large Turbulent Eddies in the Early-Morning Boundary Layer Acting as an Effective Mountain to Force Mountain Waves
Numerical modelling suggests that the turbulent boundary layer can act as an effective mountain forcing mountain waves. In the daytime, convective rolls can cover the mountains, raising the mountain-wave launching height. In non-convective conditions, the nature of the effective mountain is unknown. Here, we investigate if the early-morning boundary layer, moving rapidly across mountains, also contains large eddies of size comparable with convective cells. Temperature profiles from thousands of high-resolution radiosondes show superadiabatic gradients of vertical scale a few hundred metres in the boundary layer, appearing as the boundary-layer wind speed increases. These are explained by the overturning of potential temperature surfaces in large eddies advected with the wind and/or longitudinal rolls. An early-morning satellite image shows longitudinal rolls over mountains up to 1 km height. It is suggested that early-morning fast-moving airflow over mountains, producing mountain waves, also creates a turbulent boundary layer underneath them containing large eddies of scale a few hundred metres, in addition to classic turbulence. These are part of the effective mountain, higher than the actual mountain, which explains the formation of mountain waves.
Chayama, Kazuaki; Hayes, C Nelson
Sustained virological response (SVR) rates have increased dramatically following the approval of direct acting antiviral (DAA) therapies. While individual DAAs have a low barrier to resistance, most patients can be successfully treated using DAA combination therapy. However, DAAs are vulnerable to drug resistance, and resistance-associated variants (RAVs) may occur naturally prior to DAA therapy or may emerge following drug exposure. While most RAVs are quickly lost in the absence of DAAs, compensatory mutations may reinforce fitness. However, the presence of RAVs does not necessarily preclude successful treatment. Although developments in hepatitis C virus (HCV) therapy in Asia have largely paralleled those in the United States, Japan's July 2014 approval of asunaprevir plus daclatasvir combination therapy as the first all-oral interferon-free therapy was not repeated in the United States. Instead, two different combination therapies were approved: sofosbuvir/ledipasvir and paritaprevir/ritonavir/ombitasvir/dasabuvir. This divergence in treatment approaches may lead to differences in resistance challenges faced by Japan and the US. However, the recent approval of sofosbuvir plus ledipasvir in Japan and the recent submissions of petitions for approval of paritaprevir/ritonavir plus ombitasvir suggest a trend towards a new consensus on emerging DAA regimens. PMID:26473914
78 FR 67142 - HHCB (1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8,-hexamethylcyclopenta[γ]-2-benzopyran) TSCA Risk...
...) chemical risk assessment, ``TSCA Workplan Chemical Risk Assessment for HHCB.'' EPA will hold three peer... technical information contact: Stan Barone, Jr., Risk Assessment Division (7403M), Office of Pollution.... Background On January 9, 2013, EPA published a document in the Federal Register (78 FR 1856) (FRL-9375-1)...
Exploring Existence Value
Madariaga, Bruce; McConnell, Kenneth E.
The notion that individuals value the preservation of water resources independent of their own use of these resources is discussed. Issues in defining this value, termed "existence value," are explored. Economic models are employed to assess the role of existence value in benefit-cost analysis. The motives underlying existence value are shown to matter to contingent valuation measurement of existence benefits. A stylized contingent valuation experiment is used to study nonusers' attitudes regarding projects to improve water quality in the Chesapeake Bay. Survey results indicate that altruism is one of the motives underlying existence value and that goods other than environmental and natural resources may provide existence benefits.
Robotic tele-existence
Tachi, Susumu; Arai, Hirohiko; Maeda, Taro
Tele-existence is an advanced type of teleoperation system that enables a human operator at the controls to perform remote manipulation tasks dexterously with the feeling that he or she exists in the remote anthropomorphic robot in the remote environment. The concept of a tele-existence is presented, the principle of the tele-existence display method is explained, some of the prototype systems are described, and its space application is discussed.
Uranium effluent testing for the Oak Ridge Toxic Substances Control Act mixed waste incinerator
Shor, J.T.; Bostick, W.D.; Hoffmann, D.P.; Gibson, L.V. Jr.; Ho, T.C.
The Oak Ridge K-25 Site Toxic Substances Control Act (TSCA) Incinerator has been undergoing a series of routine tests to determine uranium partitioning to the stack, scrubber waters, and bottom ash. This paper discusses the results of the most recent experiment in which relatively high rates of uranium stack gas emissions were identified: 6.11 g/h or 8 wt % based on the uranium feed. These data are compared with earlier data, and an empirical correlation is suggested between the stack emissions of uranium and the product of the uranium and chlorine concentration of the feed. This is consistent with certain findings with other metals, in which increasing chlorine feed contents led to increasing emissions.
This essay argues for the existence of a form of unconscious racism. Research on implicit prejudice provides good evidence that most persons have deeply held negative associations with minority groups that can lead to subtle discrimination without conscious awareness. The evidence for implicit attitudes is briefly reviewed. Criticisms of the…
International Commission on Radiological Protection (ICRP) Publication 103 removed the distinction between practices and interventions, and introduced three types of exposure situation: existing, planned, and emergency. It also emphasised the optimisation principle in connection with individual dose restrictions for all controllable exposure situations. Existing exposure situations are those resulting from sources, natural or man-made, that already exist when a decision on control has to be taken. They have common features to be taken into account when implementing general recommendations, such as: the source may be difficult to control; all exposures cannot be anticipated; protective actions can only be implemented after characterisation of the exposure situation; time may be needed to reduce exposure below the reference level; levels of exposure are highly dependent on individual behaviour and present a wide spread of individual dose distribution; exposures at work may be adventitious and not considered as occupational exposure; there is generally no potential for accident; many stakeholders have to be involved; and many factors need to be considered. ICRP is currently developing a series of reports related to the practical implementation of Publication 103 to various existing exposure situations, including exposure from radon, exposure from cosmic radiation in aviation, exposure from processes using naturally occurring radioactive material, and exposure from contaminated sites due to past activities. PMID:26975365
Sibner, Lesley; Sibner, Robert; Yang, Yisong
EXIST Perspective for SFXTs
Ubertini, Pietro; Sidoli, L.; Sguera, V.; Bazzano, A.
Supergiant Fast X-ray Transients (SFXTs) are one of the most interesting (and unexpected) results of the INTEGRAL mission. They are a new class of HMXBs displaying short hard X-ray outbursts (duration less tha a day) characterized by fast flares (few hours timescale) and large dinamic range (10E3-10E4). The physical mechanism driving their peculiar behaviour is still unclear and highly debated: some models involve the structure of the supergiant companion donor wind (likely clumpy, in a spherical or non spherical geometry) and the orbital properties (wide separation with eccentric or circular orbit), while others involve the properties of the neutron star compact object and invoke very low magnetic field values (B < 1E10 G) or alternatively very high (B>1E14 G, magnetars). The picture is still highly unclear from the observational point of view as well: no cyclotron lines have been detected in the spectra, thus the strength of the neutron star magnetic field is unknown. Orbital periods have been measured in only 4 systems, spanning from 3.3 days to 165 days. Even the duty cycle seems to be quite different from source to source. The Energetic X-ray Imaging Survey Telescope (EXIST), with its hard X-ray all-sky survey and large improved limiting sensitivity, will allow us to get a clearer picture of SFXTs. A complete census of their number is essential to enlarge the sample. A long term and continuous as possible X-ray monitoring is crucial to -(1) obtain the duty cycle, -(2 )investigate their unknown orbital properties (separation, orbital period, eccentricity),- (3) to completely cover the whole outburst activity, (4)-to search for cyclotron lines in the high energy spectra. EXIST observations will provide crucial informations to test the different models and shed light on the peculiar behaviour of SFXTs.
... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Compliance with existing laws. 11.3... for Debt Collection § 11.3 Compliance with existing laws. The procurement of the services of private... procedures mandated by Federal law, and set forth in the Federal Property and Administrative Services Act...
5 CFR 2640.206 - Existing agency exemptions.
... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Existing agency exemptions. 2640.206..., EXEMPTIONS AND WAIVER GUIDANCE CONCERNING 18 U.S.C. 208 (ACTS AFFECTING A PERSONAL FINANCIAL INTEREST) Exemptions Pursuant to 18 U.S.C. 208(b)(2) § 2640.206 Existing agency exemptions. An employee who, prior...
Effluent testing for the Oak Ridge Toxic Substances Control Act mixed waste incinerator emissions tests of January 16 and 18, 1991
Shor, J.T. ); Bostick, W.D.; Coroneos, A.C.; Bunch, D.H.; Gibson, L.V.; Hoffmann, D.P.; Shoemaker, J.L. )
On January 16 and 18, 1991, special emissions tests were conducted at the Oak Ridge, K-25 Site Toxic Substances Control Act (TSCA) Incinerator. Both tests were approximately 6 h long and were performed at TSCA temperatures (1200{degrees}C, secondary combustion chamber (SSC)). Liquid feed and effluent samples were collected every 30 min. A filter was used to collect particles from stack gases to study morphology and composition during the first test. Isokinetic air samples were also taken during the second test. Metals emissions from the second test were evaluated using the Environmental Protection Agency (EPA) Method 5 sampling train. The aqueous waste was collected and fed in batches to the Central Neutralization Facility (CNF), where it was treated by iron coprecipitation and polymer flocculation and data were collected. In the first test (1-16-91), the aqueous and organic wastes were fed directly to the kiln or primary combustion chamber (PCC). In the second test (1-18-91), the remaining organic waste from the first test was fed into the SSC, and other organic waste was fed into the PCC. One objective of the two tests was to determine if feeding the same organic waste into the two combustion chambers made a difference in a partitioning of uranium and other metals. No evaluation of radionuclides other than uranium was made. The partition coefficient of uranium to the quench water was 0.3 on January 16 and 0.35 on January 18; so directing Tank 306A to the feed to the primary vs the secondary combustion chamber appears to have made little difference. The partition coefficient of uranium to the stack on January 18 was 0.0039. 5 refs., 15 figs., 26 tabs.
Shor, J.T.; Bostick, W.D.; Coroneos, A.C.; Bunch, D.H.; Gibson, L.V.; Hoffmann, D.P.; Shoemaker, J.L.
On January 16 and 18, 1991, special emissions tests were conducted at the Oak Ridge, K-25 Site Toxic Substances Control Act (TSCA) Incinerator. Both tests were approximately 6 h long and were performed at TSCA temperatures [1200{degrees}C, secondary combustion chamber (SSC)]. Liquid feed and effluent samples were collected every 30 min. A filter was used to collect particles from stack gases to study morphology and composition during the first test. Isokinetic air samples were also taken during the second test. Metals emissions from the second test were evaluated using the Environmental Protection Agency (EPA) Method 5 sampling train. The aqueous waste was collected and fed in batches to the Central Neutralization Facility (CNF), where it was treated by iron coprecipitation and polymer flocculation and data were collected. In the first test (1-16-91), the aqueous and organic wastes were fed directly to the kiln or primary combustion chamber (PCC). In the second test (1-18-91), the remaining organic waste from the first test was fed into the SSC, and other organic waste was fed into the PCC. One objective of the two tests was to determine if feeding the same organic waste into the two combustion chambers made a difference in a partitioning of uranium and other metals. No evaluation of radionuclides other than uranium was made. The partition coefficient of uranium to the quench water was 0.3 on January 16 and 0.35 on January 18; so directing Tank 306A to the feed to the primary vs the secondary combustion chamber appears to have made little difference. The partition coefficient of uranium to the stack on January 18 was 0.0039. 5 refs., 15 figs., 26 tabs.
BASIC ENGINEERING RESEARCH FOR D&D OF R.REACTOR STORAGE POND SLUDGE: ELECTROKINETICS, CARBON DIOXIDE EXTRACTION, AND SUPERCRITICAL WATER OXIDATION
Large quantities of mixed low level waste (MLLW) that fall under the Toxic Substances Control Act (TSCA) exist and continue to be generated at DOE sites across the country. Currently, the volume of these wastes is 23,500 m3, and the majority of these wastes (i.e., almost 19,000 m...
76 FR 49471 - Agency Information Collection Activities; Proposed Collection; Comment Request
...In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request to renew an existing approved Information Collection Request (ICR) to the Office of Management and Budget (OMB). This ICR, entitled: ``TSCA Section 4 Test Rules, Consent Orders, Test Rule Exemptions, and Voluntary Data Submission'' and identified by......
On the Possible Existence of Wormholes Without Gravitational Forces
Krechet, V. G.; Oshurko, V. B.; Sinil'shchikova, I. V.
A study of the existence of "wormholes" and pathways of their formation, which is a problem of current interest, is continued. Of especial interest is the possible existence of traversable "wormholes," in particular those in which gravitational forces do not act on test particles. It is shown that in the presence of a vortex gravitational field interacting with self-gravitating physical fields, such conditions can be met.
20 CFR 220.131 - Work which exists in the national economy.
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Work which exists in the national economy... RETIREMENT ACT DETERMINING DISABILITY Vocational Considerations § 220.131 Work which exists in the national economy. (a) General. The Board considers that work exists in the national economy when it exists...
Nikoskelainen, E; Nummelin, K; Savontaus, M L
This study gives some illustrative case reports of the difficulties in the diagnosis of Leber's hereditary optic neuroretinopathy. It underlies the importance of careful family history and search for peripapillary microangiopathy in the maternal relatives of patients suspected to suffer from Leber's disease. The article casts doubt on the existence of so-called sporadic Leber's disease. PMID:2977137
16 CFR 301.11 - Fictitious or non-existing animal designations prohibited.
... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Fictitious or non-existing animal designations prohibited. 301.11 Section 301.11 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.11 Fictitious or non-existing animal...
... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Fictitious or non-existing animal designations prohibited. 301.11 Section 301.11 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.11 Fictitious or non-existing animal...
... Section 11.3 Judicial Administration DEPARTMENT OF JUSTICE DEBT COLLECTION Retention of Private Counsel for Debt Collection § 11.3 Compliance with existing laws. The procurement of the services of private... procedures mandated by Federal law, and set forth in the Federal Property and Administrative Services Act...
... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Existing rights and remedies. 292.314 Section 292.314 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... cogeneration facility or qualifying small power production facility under this Act (including the right...
... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Existing rights and remedies. 292.314 Section 292.314 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... cogeneration facility or qualifying small power production facility under this Act (including the right...
... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Existing rights and remedies. 292.314 Section 292.314 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... cogeneration facility or qualifying small power production facility under this Act (including the right...
... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Existing rights and remedies. 292.314 Section 292.314 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... cogeneration facility or qualifying small power production facility under this Act (including the right...
Purpose of review The purpose is to review the arguments for increasing use of existing data in health research. Recent Findings The reuse of data in observational, exploratory and outcome studies, as well as in confirming other findings, is being justified on epistemological grounds as the major path to new knowledge and to the generalizing of findings to “real world” populations. It is also justified on grounds of cost, power and efficiency, even though data reuse comes with real informatics, scientific culture, societal and regulatory issues. Summary Data reuse is becoming more compelling. When contemplating new research for any purpose other than RCTs for efficacy, it is prudent to consider whether partnership with existing data holders should be part of the optimal research plan. PMID:24625777
The EXIST Mission Concept Study
Fishman, Gerald J.; Grindlay, J.; Hong, J.
EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in
Existence of undiscovered Uranian satellites
Structure in the Uranian ring system as observed in recent occultations may contain indirect evidence for the existence of undiscovered satellites. Using the Alfven and Arrhenius (1975, 1976) scenario for the formation of planetary systems, the orbital radii of up to nine hypothetical satellites interior to Miranda are computed. These calculations should provide interesting comparisons when the results from the Voyager 2 encounter with Uranus are made public. 15 refs., 1 fig., 1 tab.
Cogeneration for existing alfalfa processing
This study is designed to look at the application of gas-turbine generator cogeneration to a typical Nebraska alfalfa processing mill. The practicality is examined of installing a combustion turbine generator at a plant site and modifying existing facilities for generating electricity, utilizing the electricity generated, selling excess electricity to the power company and incorporating the turbine exhaust flow as a drying medium for the alfalfa. The results of this study are not conclusive but the findings are summarized.
Amendments to the asbestos in schools provisions of TSCA: report to accompany H. R. 3893. Introduced in the House of Representatives, One Hundredth Congress, Second Session, June 27, 1988
H.R. 3893 amends the Asbestos Hazard Emergency Response Act (AHERA), Title II of the Toxic Substances Control Act, to allow local education agencies to obtain a deferral to May 9, 1989, of the October 12, 1988, statutory deadline for submission of asbestos management plans to State Governors. To obtain the deferral, a local education agency must submit a request for one or all of the school buildings in its district to the State Governor no later than October 12, 1988. The request will be deemed approved upon a finding by the Governor that the deferred request is complete. H.R. 3893 also codifies existing regulations which protect employees of school buildings from being exposed to asbestos-containing material without proper training or inspections to determine whether the building material contains asbestos. The Committee on Energy and Commerce reports favorably on H.R. 3893, as amended, and recommends its passage.
Heddle, J A; Cosentino, L; Dawod, G; Swiger, R R; Paashuis-Lew, Y
Self-renewing tissues have a differentiation hierarchy such that the stem cells are the only permanent residents of the tissue, and it is in these cells that most cancerous mutations arise. The progeny of the stem cells either remain stem cells or enter a transient proliferating cell population that differentiates to produce the functional cells of the tissue. The reason that this differentiation hierarchy exists has not been established. We show here that alternative hierarchies, in which there would be no stem cells, are feasible and biologically plausible. We show that current evidence from somatic mutation frequencies at both transgenic and endogenous loci implicates cell division in the origin of most somatic mutations. We suggest, therefore, that the existence of stem cells is an evolutionary consequence of a selective pressure to avoid cancer by reducing the number of somatic mutations. The stem cell hierarchy reduces the number of cell divisions of those cells that reside permanently in the tissue, which reduces the number of somatic mutations and thus minimizes the cancer rate. In the small intestine, the existence of stem cells reduces the mutant frequency in the stem cells by about one order of magnitude. Since two or more mutations are required to transform a cell, the protective effect may be 100-fold or more. Similar factors may be expected in other tissues. PMID:8991061
Existing technology transfer reports. Summary
From 1974 to 1980, Air Products and Chemicals, Inc. (APCI) conducted a broad spectrum of internal research projects on coal, coal liquefaction processing, and coal liquids analysis. The sum of all of these projects is reported to the United States Department of Energy (DOE) by a set of five Existing Technology Transfer Reports under the following titles: (1) Liquefaction Process and Product Studies, DOE/OR/03054-109; (2) Filtration and Deashing Technology, DOE/OR/03054-118; (3) Dissolver Cold-Flow Modelling, DOE/OR/03054-108; (4) Second-Stage Support, DOE/OR/03054-117; and (5) Analytical Capabilities, DOE/OR/03054-116. This summary report provides an overview of the five Existing Technology Transfer Reports by highlighting the program objectives/results and listing the documents in which the original experimental data are contained. These documents are presented as either an attached appendix or as a file of raw data maintained by the US DOE and the International Coal Refining Company (ICRC).
One of the least studied universal deformations of incompressible nonlinear elasticity, namely the straightening of a sector of a circular cylinder into a rectangular block, is revisited here and, in particular, issues of existence and stability are addressed. Particular attention is paid to the system of forces required to sustain the large static deformation, including by the application of end couples. The influence of geometric parameters and constitutive models on the appearance of wrinkles on the compressed face of the block is also studied. Different numerical methods for solving the incremental stability problem are compared and it is found that the impedance matrix method, based on the resolution of a matrix Riccati differential equation, is the more precise. PMID:24711723
77 FR 45600 - Certain New Chemicals; Receipt and Status Information
...Section 5 of the Toxic Substances Control Act (TSCA) requires any person who intends to manufacture (defined by statute to include import) a new chemical (i.e., a chemical not on the TSCA Chemical Substances Inventory (TSCA Inventory)) to notify EPA and comply with the statutory provisions pertaining to the manufacture of new chemicals. Under TSCA sections 5(d)(2) and 5(d)(3), EPA is required......
76 FR 43327 - Certain New Chemicals; Receipt and Status Information
76 FR 57734 - Certain New Chemicals; Receipt and Status Information
77 FR 48514 - Certain New Chemicals; Receipt and Status Information
76 FR 69723 - Certain New Chemicals; Receipt and Status Information
77 FR 10512 - Certain New Chemicals; Receipt and Status Information
76 FR 76963 - Certain New Chemicals; Receipt and Status Information
76 FR 58498 - Certain New Chemicals; Receipt and Status Information
76 FR 36109 - Certain New Chemicals; Receipt and Status Information
77 FR 33761 - Privacy Act of 1974; Notification to Update an Existing Privacy Act System of Records, “Grievance...
... supersedes notice previously published on September 11, 1980 at 45 FR 27973. DATES: Effective Date: This... Agencies Responsibilities for Maintaining Records About Individuals,'' dated July 25, 1993 (58 FR 36075... records of internal grievance and arbitration systems that HUD may establish through negotiations...
75 FR 25904 - Privacy Act of 1974; as Amended; Proposed Alteration to an Existing Privacy Act System of Records...
... to a data breach. (See 72 FR 69723 (December 10, 2007).) Accordingly, we are establishing routine... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY..., Housekeeping Changes, and New Routine Uses AGENCY: Social Security Administration (SSA). ACTION: Altered...
Muñoz-Garach, Araceli; Cornejo-Pareja, Isabel; Tinahones, Francisco J.
The relationship between obesity and other metabolic diseases have been deeply studied. However, there are clinical inconsistencies, exceptions to the paradigm of “more fat means more metabolic disease”, and the subjects in this condition are referred to as metabolically healthy obese (MHO).They have long-standing obesity and morbid obesity but can be considered healthy despite their high degree of obesity. We describe the variable definitions of MHO, the underlying mechanisms that can explain the existence of this phenotype caused by greater adipose tissue inflammation or the different capacity for adipose tissue expansion and functionality apart from other unknown mechanisms. We analyze whether these subjects improve after an intervention (traditional lifestyle recommendations or bariatric surgery) or if they stay healthy as the years pass. MHO is common among the obese population and constitutes a unique subset of characteristics that reduce metabolic and cardiovascular risk factors despite the presence of excessive fat mass. The protective factors that grant a healthier profile to individuals with MHO are being elucidated. PMID:27258304
Muñoz-Garach, Araceli; Cornejo-Pareja, Isabel; Tinahones, Francisco J
The relationship between obesity and other metabolic diseases have been deeply studied. However, there are clinical inconsistencies, exceptions to the paradigm of "more fat means more metabolic disease", and the subjects in this condition are referred to as metabolically healthy obese (MHO).They have long-standing obesity and morbid obesity but can be considered healthy despite their high degree of obesity. We describe the variable definitions of MHO, the underlying mechanisms that can explain the existence of this phenotype caused by greater adipose tissue inflammation or the different capacity for adipose tissue expansion and functionality apart from other unknown mechanisms. We analyze whether these subjects improve after an intervention (traditional lifestyle recommendations or bariatric surgery) or if they stay healthy as the years pass. MHO is common among the obese population and constitutes a unique subset of characteristics that reduce metabolic and cardiovascular risk factors despite the presence of excessive fat mass. The protective factors that grant a healthier profile to individuals with MHO are being elucidated. PMID:27258304
40 CFR 717.1 - Scope and compliance.
... ACT RECORDS AND REPORTS OF ALLEGATIONS THAT CHEMICAL SUBSTANCES CAUSE SIGNIFICANT ADVERSE REACTIONS TO... Substances Control Act (TSCA) requires manufacturers, processors, and distributors of chemical substances...
Aspects of the new Employee Polygraph Protection Act are discussed, including exemptions, prohibited devices, limitations, exceptions, injury and access requirements, reasonable suspicion, drug industry investigations, procedural requirements, disclosure, basis for discharge, enforcement and remedies, and preemption and existing state laws. (MSE)
... designations prohibited. 301.11 Section 301.11 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER FUR PRODUCTS LABELING ACT Regulations § 301.11 Fictitious or non-existing animal designations prohibited. No trade names, coined names, nor other names...
... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...
... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...
... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Existing projects. 200.24 Section... Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.24 Existing projects. A mortgage financing the purchase or refinance of an existing rental housing project...
75 FR 34755 - Privacy Act; Proposed Alteration to Existing Systems of Records, Single Family Mortgage Asset...
..., this notice supersedes previous notice published at 73 FR 41105 on July 17, 2008. DATES: Effective Date... Responsibilities for Maintaining Records About Individuals,'' July 25, 1994; 59 FR 37914. Authority: 5 U.S.C. 552a... Citrix Server). CATEGORIES OF INDIVIDUALS COVERED BY THE SYSTEM: Mortgagors (Secretary-Held First,...
77 FR 60620 - Update of Existing Privacy Act-NASA Regulations
..., as amended, 88 Stat. 1896, 5 U.S.C. 552a. Sec. 1212.100 0 2. Section 1212.100 is amended by removing... ``related'' and adding in its place the word ``relates''; and 0 c. By removing paragraph (i). Subpart 1212.2--Requests for Access to Records 0 4. The heading for subpart 1212.2 is revised to read as set forth above....
75 FR 17938 - Privacy Act of 1974; Deletion of an Existing System of Records
... consolidate it with ``Public Health Service (PHS) and National Health Service Corps~NHSC) Scholarship/Loan... National Health Service Corps~NHSC) Scholarship/Loan Repayment Participants Records System, HHS/HRSA/...
75 FR 17937 - Privacy Act of 1974; Deletion of an Existing System of Records
... the ``Physician Shortage Area Scholarship Program, HHS, HRSA, ] BPHC'' HRSA System No. 09-15-0042...) and National Health Service Corps~NHSC) Scholarship/Loan Repayment Participants Records System, HHS.... SUPPLEMENTARY INFORMATION: The Physician Shortage Area Scholarship Program (PSASP) system of records...
76 FR 66917 - Privacy Act of 1974; Notice To Amend an Existing System of Records
..., Office of Departmental Personnel Security (HS-53), Office of Health, Safety and Security, U.S. Department...), Office of Health, Safety and Security, U.S. Department of Energy, 1000 Independence Ave., SW., Washington..., Principal Deputy Chief for Mission Support Operations, Office of Health, Safety and Security. DOE-43...
75 FR 8731 - Privacy Act of 1974, as Amended; Revisions to the Existing System of Records
...: The Department of the Interior (DOI) is issuing public notice of its intent to amend a Department-wide... 1974 (5 U.S.C. 552a). DOI-71, ``Electronic FOIA Tracking System and FOIA Case Files--Interior,'' is... Department of the Interior (DOI), Washington, DC 20240. SYSTEM MANAGER AND ADDRESS: The additional...
[Existence of an anabolically acting principle in an extract of E. coli].
Schole, J; Sallmann, H P; Sonnenschein, B
Colibiogen, extracted from E. coli (in the following called coli extract) was examined for factors with anabolic efficiency, especially for anabolically efficient bases of nucleic acids and for peptides. The results obtained are the following: Tests for nucleotides, nucleosides and bases of nucleic acids by thin-layer chromatography technique turned out negative. To test anabolically efficient substances the so-called glutathione state test in the rat liver was used. In this test intraportal dosages of 200 micrograms coli extract and also 200 micrograms of the enzymatically decomposed muscle proteins (Pepton resp. Lab Lemco) gave rise to positive effects within 2 min. Contrary to peptides from the culture medium the efficiency of coli extract was considerably increased by previous tryptic fission (efficient concentration 6 micrograms). The quantities applied were related on microgram peptide. A coli extract preparation the phase of growth of which had been shortened to 12 h was separated into 4 fractions. The fourth fraction (lowest molecular weight) showed anabolic efficiency with 6 micrograms peptide in the state test. Before the denaturative extraction took place, the coli extract was separated by centrifugation in a third test series into coli extract bacteria mass and coli extract supernatant. Nothing but the supernatant showed anabolic properties. Two fractions, obtained by the separation of the bacteria mass, did not show any activity in the glutathione state test. It is discussed that E. coli-specific peptides with anabolic efficiency are candidates for the coli extract effects. PMID:3535812
77 FR 73694 - Privacy Act of 1974: Update Existing System of Records
... published in the Federal Register of February 7, 1980 (45 FR 8399). hh. To disclose relevant information... enforcement action. nn. To disclose records on former Panama Canal Commission employees to the Republic of Panama for use in employment matters. oo. To disclose to appropriate Federal officials...
Understanding the Safeguarding Vulnerable Groups Act 2006.
The Safeguarding Vulnerable Groups Act 2006 was enacted as a result of the Government adopting the recommendations of the Bichard Inquiry (2004), that looked into the circumstances surrounding the death of two children in Soham in 2002. The 2006 Act provides a new vetting and barring scheme to replace the existing arrangements for safeguarding children and vulnerable adults from harm, or the risk of harm, by employees and volunteers whose work gives them significant access to these vulnerable groups. The Act extends statutory vetting and barring schemes to the health service as well as the social care sector. It is therefore important that district nurses are aware of the provisions of the Act and the timetable for implementation. This will enable them to better understand their legal duties, in order to protect themselves from liability and to protect their patients from abuse. PMID:19597384
7 CFR 1955.134 - Loss, damage, or existing defects in inventory real property.
... 7 Agriculture 14 2010-01-01 2009-01-01 true Loss, damage, or existing defects in inventory real... Disposal of Inventory Property General § 1955.134 Loss, damage, or existing defects in inventory real... a result of fire, vandalism, or an act of God between the time of acceptance of the bid or offer...
Andreis, Luisa; Barbato, David; Collet, Francesca; Formentin, Marco; Provenzano, Luigi
We consider an inviscid stochastically forced dyadic model, where the additive noise acts only on the first component. We prove that a strong solution for this problem exists and is unique by means of uniform energy estimates. Moreover, we exploit these results to establish strong existence and uniqueness of the stationary distribution.
76 FR 43230 - National Pollutant Discharge Elimination System-Cooling Water Intake Structures at Existing...
... published April 20, 2011, at 76 FR 22174, must be received on or before August 18, 2011. ADDRESSES: Submit... Water Intake Structures at Existing Facilities and Phase I Facilities AGENCY: Environmental Protection... proposed requirements under section 316(b) of the Clean Water Act for all existing power...
Ashley, W. R., III
The sharing of information between law enforcement agencies is a premise for the success of all jurisdictions. A wealth of information resides in both the databases and infrastructures of local, state, and regional agencies. However, this information is often not available to the law enforcement professionals who require it. When the information is, available, individual investigators must not only know that it exists, but where it resides, and how to retrieve it. In many cases, these types of cross-jurisdictional communications are limited to personal relationships that result from telephone calls, faxes, and in some cases, e-mail. As criminal elements become more sophisticated and distributed, law enforcement agencies must begin to develop infrastructures and common sharing mechanisms that address a constantly evolving criminal threat. Historically, criminals have taken advantage of the lack of communication between law enforcement agencies. Examples of this are evident in the search for stolen property and monetary dealings. Pawned property, cash transactions, and failure to supply child support are three common cross- jurisdictional crimes that could be better enforced by strengthening the lines of communication. Criminal behavior demonstrates that it is easier to profit from their actions by dealing in separate jurisdictions. For example, stolen property is sold outside of the jurisdiction of its origin. In most cases, simply traveling a short distance to the adjoining county or municipality is sufficient to ensure that apprehension of the criminal or seizure of the stolen property is highly unlikely. In addition to the traditional burglar, fugitives often sell or pawn property to finance their continued evasion from the law. Sharing of information in a rapid manner would increase the ability of law enforcement personnel to track and capture fugitives, as well as criminals. In an example to combat this threat, the State of Florida recently acted on the need to
76 FR 38170 - Toxic Substances Control Act Chemical Testing; Receipt of Test Data
... issue of March 16, 2006 (71 FR 13708) (FRL-7335-2). Section 4(d) of TSCA (15 U.S.C. 2603(d)) requires... Toxicity to Fish. 9. Acute Toxicity to Aquatic Invertebrates. 10. Toxicity to Aquatic Plants, e.g.,...
Existence of equilibria in articulated bearings
Buscaglia, G.; Ciuperca, I.; Hafidi, I.; Jai, M.
The existence of equilibrium solutions for a lubricated system consisting of an articulated body sliding over a flat plate is considered. Though this configuration is very common (it corresponds to the popular tilting-pad thrust bearings), the existence problem has only been addressed in extremely simplified cases, such as planar sliders of infinite width. Our results show the existence of at least one equilibrium for a quite general class of (nonplanar) slider shapes. We also extend previous results concerning planar sliders.
... 47 Telecommunication 1 2014-10-01 2014-10-01 false Existing structures. 17.17 Section 17.17... STRUCTURES Federal Aviation Administration Notification Criteria § 17.17 Existing structures. Link to an... painting and lighting of antenna structures shall not apply to those structures authorized prior to July...
... 47 Telecommunication 1 2013-10-01 2013-10-01 false Existing structures. 17.17 Section 17.17... STRUCTURES Federal Aviation Administration Notification Criteria § 17.17 Existing structures. (a) The requirements found in § 17.23 relating to painting and lighting of antenna structures shall not apply to...
47 CFR 17.24 - Existing structures.
... 47 Telecommunication 1 2014-10-01 2014-10-01 false Existing structures. 17.24 Section 17.24... STRUCTURES Specifications for Obstruction Marking and Lighting of Antenna Structures § 17.24 Existing structures. No change to painting or lighting criteria or relocation of airports shall at any time impose...