Source: http://www.google.com/patents/US7628851?dq=7125605
Timestamp: 2015-07-05 18:25:52
Document Index: 317423583

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 2004273794', 'Application No. 200480032523', 'Application No. 200480032523', 'Application No. 04750971', 'Application No. 04809690', 'Application No. 04809690', 'Application No. 2002', 'Application No. 2002']

Patent US7628851 - Bone cement compositions having fiber-reinforcement and/or increased flowability - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsThe present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized...http://www.google.com/patents/US7628851?utm_source=gb-gplus-sharePatent US7628851 - Bone cement compositions having fiber-reinforcement and/or increased flowabilityAdvanced Patent SearchPublication numberUS7628851 B2Publication typeGrantApplication numberUS 12/130,287Publication dateDec 8, 2009Filing dateMay 30, 2008Priority dateSep 5, 2003Fee statusPaidAlso published asCA2539751A1, EP1663333A2, US7494950, US8057595, US20050208094, US20080226691, US20100048763, WO2005027988A2, WO2005027988A3Publication number12130287, 130287, US 7628851 B2, US 7628851B2, US-B2-7628851, US7628851 B2, US7628851B2InventorsBryan Monro Armitage, Ira C Ison, Mark Thomas Fulmer, Sean Hamilton Kerr, Michael Lehmicke, Patrick Leamy, William SchifferOriginal AssigneeSynthes Usa, LlcExport CitationBiBTeX, EndNote, RefManPatent Citations (55), Non-Patent Citations (23), Referenced by (6), Classifications (41), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetBone cement compositions having fiber-reinforcement and/or increased flowability
US 7628851 B2Abstract
This application is a Continuation of U.S. patent application Ser. No. 10/936,188 filed on Sep. 7, 2004, and titled “BONE CEMENT COMPOSITIONS HAVING FIBER-REINFORCEMENT AND/OR INCREASED FLOWABILITY” which claims the benefit of U.S. Provisional Application No. 60/500,346, filed Sep. 5, 2003 and U.S. Provisional Application No. 60/574,532, filed May 25, 2004, the entire disclosure of each of the aforementioned applications being incorporated by reference herein in their entirety.
One aspect of the invention relates to an implantable composition comprising: (a) a calcium salt-containing component, preferably a calcium phosphate containing component, including amorphous calcium phosphate, crystalline calcium phosphate, CaHPO4, CaHPO4.H2O, α-Ca3(PO4)2, α-bar-Ca3(PO4)2, β-Ca3(PO4)2, γ-Ca3(PO4)2, Ca5(PO4)3OH, Ca10(PO4)6(OH)2, Ca4O(PO4)2, CaP4O11, α-Ca2P2O7, β-Ca2P2O7, γ-Ca2P2O7, Ca(H2PO4)2.nH2O, where n is a real number from 0 to 5, Ca8H2(PO4)6.5H2O or calcium pyrophosphate; calcium sulfates including Ca(SO4)2, α-Ca(SO4)2.1/2H2O, β-Ca(SO4)2 .1/2H2O; or any combination thereof; and (b) discrete fibers that are resorbable homopolymers or copolymers (particularly from about 1% to about 5% by weight) that have an aspect ratio from about 50:1 to about 1000:1 and that have a fiber length of about 15 mm or less. In one embodiment, the implantable composition further comprises demineralized bone. In another embodiment, the composition may include continuous reinforcing fibers. Advantageously, the composition according to the invention can further comprise a flow additive including, but not limited to, hyaluronic acid, a hyaluronate salt, a sodium phosphate salt, or a combination thereof (optionally also including continuous reinforcing fibers).
The geometry of the ends of the fibers can also have an important impact on the properties of the composite material. Typically, because fibers are often fabricated by a continuous process, it can be necessary to cut continuous fibers in order to get fibers of a desired length (e.g., tailored to the diameter thereof, based on the aspect ratio constraints described herein). In such a case, the fiber ends are typically sliced, broken, etc., and can be thought of as essentially flat and/or featureless. However, fibers having features on the ends can have advantageous effects on the properties of the fibers in the composition according to the invention. For example, beads or balls can be formed on the ends of fibers or groups of fibers, e.g., by heating one or more of the ends of the fiber(s) such that the end(s) melt or burn and thus (each) form a hemispherical end bead. For instance, about seven cylindrical poly(L-lactide-co-glycolide) copolymers (specifically, 18/82 L/G), having fiber diameters of about 15 to about 20 microns and grouped in a 2-3-2 array (i.e., a hexagonal arrangement with one fiber in the middle) most closely approximating a multifibrillar cylinder, were heated to a temperature of at least about 55� C., for example at least about 75� C., or at least about 100� C., on each end to form a ball or bead, thus joining the seven-fiber construct to form a multifibrillar fiber having an effective diameter of about 45 to about 60 microns, while maintaining a similar length. Other types of alterations to the fiber ends can also be accomplished, e.g., to form dogbone-shaped short fibers, such as described in the article of Zhu et al., “Bone-Shaped Short Fiber Composites—An Overview,” Mat. Sci. & Eng., 2002, A326, 208-227, the entire disclosure of which is hereby incorporated by express reference hereto.
In one preferred embodiment, the flow additive includes an aqueous solution containing a sodium phosphate, preferably Na2HPO4, for example consisting essentially of a solution of distilled water and Na2HPO4. In another preferred embodiment, the flow additive includes an aqueous solution containing Na2HPO4 and NaH2PO4, for example consisting essentially of a solution of distilled water, Na2HPO4 and NaH2PO4. In another embodiment, the flow additive includes an aqueous solution containing sodium chloride, and preferably consists essentially of saline. When the aqueous solution contains a salt or buffer component, the concentration of such component in solution can typically be from about 0.005 m to about 0.5 m, preferably from about 0.01 m to about 0.25 m. for example from about 0.01 m to about 0.1 m, from about 0.05 m to about 0.2 m, from about 0.075 m to about 0.25 m, or from about 0.15 m to about 0.25 m, with “m” connoting molality expressed in moles per kilogram of solution.
Comparative Example 1A is adapted from a cement commercially available from Norian Corp. of Chester, Pa. under the tradename NORIAN SRS�. Comparative Example 1B is a radiopaque cement commercially available from Norian Corp. of West Chester, Pa. under the tradename NORIAN XR™. Comparative Example 1C is adapted from a fast set cement commercially available from Norian Corp. of Chester, Pa. under the tradename NORIAN CRS�, by changing the Na2HPO4 content from about 0.15 m to about 0.075 m and by changing the L/S ratio from about 0.56 to about 0.52.
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T., et al., "Bone-Shaped Short Fiber Composites-An Overview", Materials Science and Engineering: A, 326(2), (2002), 208-227.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS8057595Nov 3, 2009Nov 15, 2011Synthes Usa, LlcBone cement compositions having fiber-reinforcement and/or increased flowabilityUS8114427Oct 18, 2005Feb 14, 2012Gerhard SchmidmaierBiologically active implantsUS8232327Nov 12, 2009Jul 31, 2012Howmedia Osteonics CorpTetra calcium phosphate based organophosphorus compositions and methodsUS8273803Dec 8, 2011Sep 25, 2012Howmedica Osteonics Corp.Tetra calcium phosphate based organophosphorus compositions and methodsUS20120277882 *Apr 27, 2012Nov 1, 2012Far Eastern New Century CorporationImplant composite particle, method for making the same, and uses thereofWO2012027711A2 *Aug 26, 2011Mar 1, 2012University Of Louisville Research Foundation, Inc.Compositions and methods for treating bone defects* Cited by examinerClassifications U.S. Classification106/691, 623/23.61, 106/775, 106/780, 623/23.58, 424/603, 106/774, 106/772, 106/776, 623/23.51, 106/35, 623/23.56, 424/602, 424/696, 106/778International ClassificationA61L27/46, A61L24/00, A61L27/50, A61L27/42, A61F2/28, A61K33/06, A61K31/74, A61K33/42Cooperative ClassificationA61L27/425, A61L27/50, A61L24/001, A61L27/46, A61L24/0084, A61L24/0063, A61K31/74, A61K33/06, A61K33/42European ClassificationA61K31/74, A61K33/06, A61L27/50, A61L27/42E, A61L24/00R2E, A61L24/00R4E, A61L24/00H, A61L27/46, A61K33/42Legal EventsDateCodeEventDescriptionFeb 23, 2009ASAssignmentOwner name: SYNTHES USA, LLC, PENNSYLVANIAFree format text: CHANGE OF NAME;ASSIGNOR:SYNTHES (U.S.A.);REEL/FRAME:022288/0928Effective date: 20081223Jun 8, 2010CCCertificate of correctionMar 12, 2013FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services