Source: http://www.google.se/patents/US8080702?hl=sv
Timestamp: 2013-06-18 20:42:39
Document Index: 220927665

Matched Legal Cases: ['Application No. 2739605', 'Application No. 200480032101', 'Application No. 2006', 'Application No. 2006', 'Application No. 2006', 'Application No. 04']

Patent US8080702 - Wound cleansing apparatus in-situ - Google PatentS�k Bilder Kartor Play YouTube Nyheter Gmail Drive Mer » Avancerad patents�kning | Webbhistorik | Logga in Avancerad patents�kning PatentAn apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing,...http://www.google.se/patents/US8080702?utm_source=gb-gplus-sharePatent US8080702 - Wound cleansing apparatus in-situ PublikationsnummerUS8080702 B2Typ av kung�relseBeviljande Ans�kningsnummer12/848,817 Publiceringsdatum20 dec 2011 Registreringsdatum2 aug 2010 Prioritetsdatum28 okt 2003�ven publicerat somCA2540878A1, CA2739605A1, CA2739605C, CN1874806A, CN1874806B, EP1684826A1, EP2298381A1, EP2311509A1, US7964766, US20070167926, US20100298793, US20110054423, US20110087179, US20120041399, US20120053538, US20120109084, WO2005051461A1 Publikationsnummer12848817, 848817, US 8080702 B2, US 8080702B2, US-B2-8080702, US8080702 B2, US8080702B2 UppfinnarePatrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Julian Lee-Webb, Derek Nicolini, Tina Michelle Walker Ursprunglig innehavareSmith & Nephew PlcCitat fr�n patent (103), Citat fr�n andra k�llor (62), H�nvisningar finns i f�ljande patent (2), Klassificeringar (27) Externa l�nkar: USPTO, �verl�telse av �gander�tt till patent som har registrerats av USPTO, EspacenetWound cleansing apparatus in-situUS 8080702 B2 Sammanfattning An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.
CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser. No. 10/575,871, published as US 2007/0167926 and filed on Jan. 29, 2007 now U.S. Pat. No. 7,964,766, which is a U.S. National Phase of the PCT International Application No. PCT/GB04/04549, filed on Oct. 28, 2004, which claims priority to application GB 0325129.5, filed on Oct. 28, 2003.
FIELD OF THE INVENTION The present invention relates to apparatus and a medical wound dressing for cleansing wounds, and a method of treating wounds using such apparatus.
BACKGROUND OF THE INVENTION Before the present invention, aspirating and/or irrigating apparatus were known, and tended to be used to remove wound exudate during wound therapy. In known forms of such wound therapy, the offtake from the wound, especially when in a highly exuding state, is voided to waste, e.g. to a collection bag.
a) can remove materials deleterious to wound healing from wound exudate, whilst a) retaining materials that are beneficial in promoting wound healing in contact with the wound bed. Dialysis is a known method of treating bodily fluids such as blood ex vivo, to cleanse them of materials that are deleterious to the body systemically. Removal of such materials by contact with the dialysate is the prime purpose of dialysis, whilst also retaining materials such as blood, cells and proteins. Other materials that may have an additional positive therapeutic action are potentially lost to the system through the dialysis membrane, which is also permeable to them. The balance of such materials in the bodily fluid in recirculation may thus be further depleted.
SUMMARY OF THE INVENTION It would be desirable to provide a system of therapy that can remove materials deleterious to wound healing from wound exudate, without substantially diluting materials that are beneficial in promoting wound healing in contact with the wound bed, and which can continuously supply and recirculate such materials to the wound simultaneously.
a) to obviate at least some of the abovementioned disadvantages of known aspiration and/or irrigation therapy systems, and b) to provide a system of therapy which can
i) remove materials deleterious to wound healing from wound exudate, whilst ii) retaining materials that are beneficial in promoting wound healing in contact with the wound bed. It is a further object of the present invention
a) to obviate at least some of the abovementioned disadvantages of known dialysis systems, and b) to provide a system of therapy which can remove materials deleterious to wound healing from wound exudate, whilst retaining materials that are beneficial in promoting wound healing in contact with the wound bed, c) without affecting the body systemically. It is a yet further object of the present invention
a) to obviate at least some of the abovementioned disadvantages of known dialysis systems, and b) to provide a system of therapy which can remove materials deleterious to wound healing from wound exudate, whilst retaining materials that are beneficial in promoting wound healing in contact with the wound bed, and c) is portable. Vascular supply to, and circulation in, tissue underlying and surrounding the wound is often compromised. It is a further object of the present invention to provide a system of therapy that retains and supplies therapeutically active amounts of materials that are beneficial in reversing this effect whilst removing deleterious materials, thereby promoting wound healing.
a conformable wound dressing, having a backing layer which is capable of forming a relatively fluid-tight seal or closure over a wound and characterised in that it also comprises a) a cleansing means for selectively removing materials that are deleterious to wound healing from wound exudate, which means is under the backing layer and sits in the underlying wound in use and b) a moving device for moving fluid through the cleansing means, and c) optionally bleed means for bleeding the cleansing means. The term �bleed means for bleeding the cleansing means� includes any bleed means that is in fluidic communication with the cleansing means.
1. A �Single-Phase System�
2. A �Multiple-Phase System�
In both single- and multiple-phase systems, it may be appropriate to design and run the device to move fluid through the wound or the cleansing means to operate the system as a �circulating system�.
Alternatively, where appropriate it may be provided in the form of a �reversing system�. That is, the relevant fluid passes through the cleansing means at least once in opposing directions.
The cleansing means may as desired be operated as a �single-pass system�, i.e. the relevant fluid passes through the cleansing means only once.
Alternatively, where appropriate it may be provided in the form of a �multiple-pass system�, in which the relevant fluid passes through the cleansing means and/or over the wound bed several times.
a) as a �circulating system�, in which the wound exudate and optionally irrigant passes through the cleansing means one or more times in only one direction (Examples of such a system are shown in FIGS. 2, 4, 8, 9, 11 and 15 hereinafter.), or
b) as a �reversing system�, i.e. the wound exudate and optionally irrigant passes through the cleansing means at least once in opposing directions. (Examples of such a system are shown in FIGS. 1, 2, 3, 6, 7, 10 and 14 hereinafter.)
i) �single-pass system�, i.e. the relevant fluid passes through the cleansing means only once, or
ii) as �multiple-pass system�, in which the relevant fluid passes through the cleansing means and/or over the wound bed several times.
a) as a �circulating system�, in which
(i) the wound exudate and optionally irrigant and/or (ii) a cleansing fluid each passes through the cleansing means one or more times in only one direction (Examples of such a system are shown in FIGS. 12 and 13 hereinafter.), or b) as a �reversing system�, i.e.
(i) the wound exudate and optionally irrigant and/or (ii) a cleansing fluid each passes through the cleansing means at least once in opposing directions. This type of cleansing may be operated as a
In such a �multiple-phase system�, where both the cleansing fluid and/or the wound exudate optionally mixed with irrigant are moving, the flows may be cocurrent or countercurrent, preferably countercurrent
The term �relatively fluid-tight seal or closure� is used herein to indicate one which is fluid- and microbe-impermeable and permits a positive or negative pressure of up to 50% atm., more usually up to 15% atm. to be applied to the wound. The term �fluid� is used herein to include gels, e.g. thick exudate, liquids, e.g. water, and gases, such as air, nitrogen, etc.
polyolefins, such as polyethylene e.g. high-density polyethylene, polypropylene, copolymers thereof, for example with vinyl acetate and polyvinyl alcohol, and mixtures thereof; polysiloxanes; polyesters, such as polycarbonates; polyamides, e.g. 6-6 and 6-10, and hydrophobic polyurethanes. They may be hydrophilic, and thus also include hydrophilic polyurethanes.
However, in particular around the periphery of the wound dressing, outside the relatively fluid-tight seal, it is preferably of a material that has a high moisture vapour permeability, to prevent maceration of the skin around the wound. It may also be a switchable material that has a higher moisture vapour permeability when in contact with liquids, e.g. water, blood or wound exudate. This may, e.g. be a material that is used in Smith & Nephew's Allevyn�, IV3000� and OpSite� dressings.
If the periphery of the wound dressing, outside the relatively fluid-tight seal, that bears an adhesive film to attach it to the skin around the wound, is of a material that has a high moisture vapour permeability or is a switchable material, then the adhesive film, if continuous, should also have a high or switchable moisture vapour permeability, e.g. be an adhesive such as used in Smith & Nephew's Allevyn�, IV3000� and OpSite� dressings.
Alternatively, it may be permanently attached or releasably attached to the dressing, in particular the backing layer, with an adhesive film, for example, or these components may be a Velcro�, push snap or twist-lock fit with each other.
In single-phase systems, the device to move fluid moves wound exudate in and out of the cleansing means through the permeable integer, either as a �circulating system� or a reversing system.
However, when used herein the term �chamber� includes any hollow body or bodies defined by a film, sheet or membrane, and is not limited to a bag, pouch or other like structure.
Examples also include gels, such as silicone gels, e.g. CaviCare� gel, or preferably cellulosic gels, for example hydrophilic cross-linked cellulosic gels, such as Intrasite� cross-linked materials. Examples also include aerosol foams, where the gaseous phase of the aerosol system is air or an inert gas, such as nitrogen or argon, more usually air, at a small positive pressure above atmospheric; and solid particulates, such as plastics crumbs.
a) a single-phase system, such as an ultrafiltration unit, or a chemical adsorption unit; or b) a two-phase system, such as a dialysis unit. In the former, fluid from the wound passes through a single flow path in which materials deleterious to wound healing are removed and the cleansed fluid, still containing materials that are beneficial in promoting wound healing is returned to the wound.
It will be appropriate to design and run the apparatus with this type of cleansing means as a �circulating system�, in which the relevant fluid passes through the cleansing means one or more times in only one direction, since this is necessary for retaining the filter residue out of the wound exudate.
(it would be inappropriate to run the system in the form of a �reversing system�, since the fluid passing through the cleansing means at least once in the reverse direction would return these materials into the wound.)
proteases, such as serine proteases, e.g. elastase, and thrombin; cysteine proteases, matrix metalloproteases, e.g. collagenase; and carboxyl (acid) proteases; endotoxins, such as lipopolysaccharides; inhibitors of angiogenesis such as thrombospondin-1 (TSP-1), plasminogen activator inhibitor, or angiostatin (plasminogen fragment); pro-inflammatory cytokines such as tumour necrosis factor alpha (TNFα) and interleukin 1 beta (IL-1β), oxidants, such as free radicals, e.g., e.g. peroxide and superoxide; and metal ions, e.g. iron II and iron III; all involved in oxidative stress on the wound bed, or basic or acidic species which adversely affect the pH in the wound exudate, such as protons, the cleansing chamber may contain, behind the permeable integer at least one of the following antagonists as appropriate that is captive in a part of the chamber where it can be in contact with the irrigant and/or wound exudate: protease inhibitors, such as serine protease inhibitors, such as 4-(2-aminoethyl)-benzene sulphonyl fluoride (AEBSF, PefaBloc) and Nα-p-tosyl-L-lysine chloromethyl ketone (TLCK) and ε-aminocaproyl-p-chlorobenzylamide; cysteine protease inhibitors; matrix metalloprotease inhibitors; and carboxyl (acid) protease inhibitors; binders and/or degraders, such as anti-inflammatory materials to bind or destroy lipopolysaccharides, e.g. peptidomimetics; anti-oxidants, such as 3-hydroxytyramine (dopamine), ascorbic acid (vitamin C), vitamin E and glutathione, and stable derivatives thereof, and mixtures thereof; to relieve oxidative stress on the wound bed: metal ion chelators and/or ion exchangers, such as transition metal ion chelators, such as iron III chelators (Fe III is involved in oxidative stress on the wound bed.), such as desferrioxamine (DFO), 3-hydroxytyramine (dopamine); iron III reductants; or agents for the adjustment of pH in the wound exudate, such as base or acid scavengers and/or ion exchangers, or other species, which may be non-labile, insoluble and/or immobilised) species, such as ScavengePore� phenethyl morpholine (Aldrich). It will be appropriate to design and run the apparatus with this type of cleansing means either as a �circulating system�, or in the form of a �reversing system�, since the fluid passing through the cleansing means at least once in the reverse direction would not return these materials into the wound.)
a) the cleansing fluid or b) the wound exudate optionally mixed with irrigant, or c) both. Examples of such systems are shown in FIGS. 12 and 13 hereinafter, in which
oxidants, such as free radicals, e.g. peroxide and superoxide; iron II and iron III; all involved in oxidative stress on the wound bed; proteases, such as serine proteases, e.g. elastase and thrombin; cysteine proteases, matrix metalloproteases, e.g. collagenase; and carboxyl (acid) proteases; endotoxins, such as lipopolysaccharides; autoinducer signalling molecules, such as homoserine lactone derivatives, e.g. oxo-alkyl derivatives; inhibitors of angiogenesis such as thrombospondin-1 (TSP-1), plasminogen activator inhibitor, or angiostatin (plasminogen fragment) pro-inflammatory cytokines such as tumour necrosis factor alpha (TNFα) and interleukin 1 beta (IL-1β); and inflammatories, such as lipopolysaccharides, and e.g. histamine; and basic or acidic species which adversely affect the pH in the wound exudate, such as protons. Examples of suitable materials for the film, sheet or membrane (typically in the form of conformable hollow bodies defined by the film, sheet or membrane, such as the structures described hereinbefore) include natural and synthetic polymeric materials.
proteases, such as serine proteases, e.g. elastase, and thrombin; cysteine proteases; matrix metalloproteases, e.g. collagenase; and carboxyl (acid) proteases; endotoxins, such as lipopolysaccharides; inhibitors of angiogenesis such as thrombospondin-1 (TSP-1), plasminogen activator inhibitor, or angiostatin (plasminogen fragment) pro-inflammatory cytokines such as tumour necrosis factor alpha (TNFα) and interleukin 1 beta (IL-1β); oxidants, such as free radicals, e.g., e.g. peroxide and superoxide; and metal ions, e.g. iron II and iron III; all involved in oxidative stress on the wound bed; and basic or acidic species which adversely affect the pH in the wound exudate, such as protons. It will however also permit components of the exudate from a wound and/or irrigant fluid that may be larger or smaller molecules, but are beneficially involved in wound healing to pass into and through it.
antagonists to such species, for example enzymes or others, such as protease inhibitors, such as serine protease inhibitors, such as 4-(2-aminoethyl)-benzene sulphonyl fluoride (AEBSF, PefaBloc) and Nα-p-tosyl-L-lysine chloromethyl ketone (TLCK) and ε-aminocaproyl-p-chlorobenzylamide; cysteine protease inhibitors; matrix metalloprotease inhibitors; and carboxyl (acid) protease inhibitors; binders and/or degraders, such as anti-inflammatory materials to bind or destroy lipopolysaccharides, e.g. peptidomimetics; anti-oxidants, such as 3-hydroxytyramine (dopamine), ascorbic acid (vitamin C), vitamin E and glutathione, and stable derivatives thereof, and mixtures thereof; to relieve oxidative stress on the wound bed; metal ion chelators and/or ion exchangers, such as transition metal ion chelators, such as iron III chelators (Fe III is involved in oxidative stress on the wound bed.), such as desferrioxamine (DFO), 3-hydroxytyramine (dopamine); iron III reductants; and agents for the adjustment of pH in the wound exudate, such as base or acid scavengers and/or ion exchangers, or other species, which may be non-labile, insoluble and/or immobilised) species, such as ScavengePore� phenethyl morpholine (Aldrich). They further include peptides (including cytokines, e.g. bacterial cytokines, such as α-amino-γ-butyrolactone and L-homocarnosine); and
A steady state concentration equilibrium is eventually set up between the dialysate and the irrigant and/or wound exudate, which is �topped up� from the wound dressing.
Unlike the other components of the exudate from a wound and/or irrigant fluid the target materials are constantly removed from the dialysate, very little of these species will pass from the dialysate into the irrigant and/or wound exudate, and a steady state concentration equilibrium is not set up, even if the species are constantly �topped up� from the wound dressing.
at least one inlet pipe for connection to a fluid return tube, which passes through the wound-facing face of the backing layer, and at least one outlet pipe for connection to a fluid offtake tube, which passes through the wound-facing face of the backing layer, the point at which the or each inlet pipe and the or each outlet pipe passes through or under the wound-facing face forming a relatively fluid-tight seal or closure over the wound. Where any pipe is described in connection with the operation of the apparatus as being connected or for connection to a (mating end of a) tube, the pipe and the tube may form a single integer.
Where the mode of running the present apparatus is in the form of a �reversing system�, the at least one inlet pipe and the at least one outlet pipe, and the at least one fluid supply tube and the at least one outlet pipe, may respectively be the same integer.
This is often in a �multiple-pass system� for irrigant and/or wound exudate where this fluid passes from the wound dressing and is returned to the wound, in both cases via the cleansing means, e.g. under the action of the movement of a reciprocating pump, such as a syringe or piston pump.
diaphragm pumps�where pulsations of one or two flexible diaphragms displace liquid while check valves control the direction of the fluid flow.
pumps�where pistons pump fluids optionally through check valves, in particular for variable and/or reversible positive and/or negative pressure on the wound bed and for closed single-phase reversing system, in which the wound exudate and/or irrigant passes to and fro through the cleansing means.
rotary vane pumps�with rotating vaned disk attached to a drive shaft moving fluid without pulsation as it spins. The outlet can be restricted without damaging the pump.
peristaltic pumps�with peripheral rollers on rotor arms acting on a flexible fluid circulation tube to urge fluid current flow in the tube in the direction of the rotor, in particular for a dialysate phase in a multiple-phase circulating system, in which it passes in only one direction.
They may be separate structures, capable of interacting as appropriate for the purpose of moving cleansing fluid along a desired flow path across the selectively permeable integer, effectively in a �multiple-pass system� within the interior of the chamber.
The chamber may thus, e.g. be provided in a form with at least one magnetic follower enclosed within it and acted upon by a magnetic stirrer to impel the cleansing fluid. The magnetic stirrer to impel the cleansing fluid may be mounted on, e.g. releasably attached to the other components of the dressing, in particular the backing layer, e.g. with a Velcro� attachment, an adhesive film (e.g. of pressure-sensitive adhesive) or elastic or non-elastic straps, bands, ties, bandages, e.g. compression bandages, sheets or covers, or be a push, snap or twist-lock fit with it/tem.
These components may be releasably attached, e.g. by a Velcro� attachment, with an adhesive film (e.g. with pressure-sensitive adhesive) or with elastic and non-elastic straps, bands, ties, bandages, e.g. compression bandages, sheets or covers.
anticoagulants, such as heparin, and high surface tension materials, such as PTFE, and polyamides, which are useful for growth factors, enzymes and other proteins and derivatives. In all embodiments of the apparatus the type and material of any tubes throughout the apparatus of the invention for irrigating and/or cleansing wounds will be largely determined by their function.
antioxidants and free radical scavengers, such as 3-hydroxytyramine (dopamine), ascorbic acid (vitamin C), vitamin E and glutathione, and stable derivatives thereof, and mixtures thereof; to relieve oxidative stress on the wound bed; metal ion chelators and/or ion exchangers, such as transition metal ion chelators, such as iron III chelators (Fe III is involved in oxidative stress on the wound bed.), such as desferrioxamine (DFO), 3-hydroxytyramine (dopamine); iron III reductants; protease inhibitors, such as TIMPs and alpha 1-antitrypsin (AAT); serine protease inhibitors, such as 4-(2-aminoethyl)-benzene sulphonyl fluoride (AEBSF, PefaBloc) and N-α-p-tosyl-L-lysine chloro-methyl ketone (TLCK) and ε-aminocaproyl-p-chlorobenzylamide; cysteine protease inhibitors; matrix metalloprotease inhibitors; and carboxyl (acid) protease inhibitors; sacrificial redox materials that are potentially or actually beneficial in promoting wound healing, by the removal of materials that trigger the expression into wound exudate of redox-sensitive genes that are deleterious to wound healing; autoinducer signalling molecule degraders, which may be enzymes; and anti-inflammatory materials to bind or destroy lipopolysaccharides, e.g. peptidomimetics; agents for the adjustment of pH in the wound exudate, such as base or acid scavengers and/or ion exchangers, or other species, which may be non-labile, insoluble and/or immobilised) species, such as ScavengePore� phenethyl morpholine (Aldrich). Other physiologically active components of the exudate that are deleterious to wound healing may be removed in this way.
heterogeneous resins, for example silica-supported reagents such as: metal scavengers, 3-(diethylenetriamino)propyl-functionalised silica gel 2-(4-(ethylenediamino)benzene)ethyl-functionalised silica gel 3-(mercapto)propyl-functionalised silica gel 3-(1-thioureido)propyl-functionalised silica gel triamine tetraacetate-functionalised silica gel or electrophilic scavengers, 4-carboxybutyl-functionalised silica gel 4-ethyl benzenesulfonyl chloride-functionalised silica gel propionyl chloride functionalised silica gel 3-(isocyano)propyl-functionalised silica gel 3-(thiocyano)propyl-functionalised silica gel 3-(2-succinic anhydride)propyl-functionalised silica gel 3-(maleimido)propyl-functionalised silica gel or nucleophilic scavengers, 3-aminopropyl-functionalised silica gel 3-(ethylenediamino)-functionalised silica gel 2-(4-(ethylenediamino)propyl-functionalised silica gel 3-(diethylenetriamino)propyl-functionalised silica gel 4-ethyl-benzenesulfonamide-functionalised silica gel 2-(4-toluenesulfonyl hydrazino)ethyl-functionalised silica gel 3-(mercapto)propyl-functionalised silica gel dimethylsiloxy-functionalised silica gel or base or acid scavengers, 3-(dimethylamino)propyl-functionalised silica gel 3-(1,3,4,6,7,8-hexahydro-2H-pyrimido-[1,2-a]pyrimidino)propyl-functionalised silica gel 3-(1-imidazol-1-yl)propyl-functionalised silica gel 3-(1-morpholino)propyl-functionalised silica gel 3-(1-piperazino)propyl-functionalised silica gel 3-(1-piperidino)propyl-functionalised silica gel 3-(4,4′-trimethyldipiperidino)propyl-functionalised silica gel 2-(2-pyridyl)ethyl-functionalised silica gel 3-(trimethylammonium)propyl-functionalised silica gel or the reagents, 3-(1-cyclohexylcarbodiimido)propyl-functionalised silica gel TEMPO-functionalised silica gel 2-(diphenylphosphino)ethyl-functionalised silica gel 2-(3,4-cyclohexyldiol)propyl-functionalised silica gel 3-(glycidoxy)propyl-functionalised silica gel 2-(3,4-epoxycyclohexyl)propyl-functionalised silica gel 1-(allyl)methyl-functionalised silica gel 4-bromopropyl-functionalised silica gel 4-bromophenyl-functionalised silica gel 3-chloropropyl-functionalised silica gel 4-benzyl chloride-functionalised silica gel 2-(carbomethoxy)propyl-functionalised silica gel 3-(4-nitrobenzamido)propyl-functionalised silica gel 3-(ureido)propyl-functionalised silica gel or any combinations of the above. The use of such captive (non-labile, insoluble and/or immobilised) species, such as the foregoing, bound to an insoluble and immobilised) substrate over and/or through which the irrigant and/or wound exudate from, the wound dressing passes has been described hereinbefore as suitable for the means for fluid cleansing.
BRIEF DESCRIPTION OF DRAWINGS The present invention will now be described by way of example only with reference to the accompanying drawings in which:
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Referring to FIGS. 1 to 10 and 14, the apparatus (1) for cleansing wounds comprises
a conformable wound dressing (2), having a backing layer (3) which is capable of forming a relatively fluid-tight seal or closure over a wound and bears an adhesive film, to attach it to the skin sufficiently to hold the wound dressing (2) in place; a cleansing means (4) for selectively removing materials that are deleterious to wound healing from wound exudate, which means is under the backing layer (3) and sits in the underlying wound in use; and a moving device (7) for moving fluid through the cleansing means. Optional means for bleeding or supplying fluid to the cleansing means (4) or to exudate under the backing layer, e.g. a regulator, such as a valve are omitted in most of the Figures.
EXAMPLE 1 Cleansing Fe(II) from Aqueous Solution with the Apparatus of FIG. 1: Single-Phase Hand-Syringe Pumped Dressing Containing Solid Sequestrant (Cadexomer-Desferrioxamine) A hand-syringe pumped dressing as shown in FIG. 14 was made up. The cleansing chamber (15) contains a solid particulate (not shown) desferrioxamine supported on Cadexomer (50 mg) to sequester and remove deleterious Fe(II) ions from surrogate exudate.
EXAMPLE 2 Neutralising the pH of an Acidic Solution with the Apparatus of FIG. 15: Single-Phase Recirculating Pumped Dressing Containing Solid Acid Scavenger, ScavengePore� Phenethyl Morpholine A recirculating pumped dressing as shown in FIG. 15 was made up. The cleansing chamber (15) contains a solid particulate (not shown) of ScavengePore� phenethyl morpholine (Aldrich) (50 mg), which is a low-swelling macroporous highly crosslinked polystyrene/divinylbenzene ion-exchanger resin matrix, with 200-400 micron particle size, to scavenge and remove protons, which are acidic species which adversely affect the pH in the wound exudate, from surrogate exudate.
EXAMPLE 3 Cleansing Elastase from Aqueous Solution by Diffusion Across a Dialysis Membrane with the Apparatus of FIG. 12: Two-Phase Recirculating Pumped Dressing Containing No Reagent A recirculating pumped dressing as shown in FIG. 12 was made up. The cleansing chamber (5) is in the form of tubules made from a polymer membrane that is selectively permeable to a deleterious materials in wound exudate (elastase). These in an array under the backing layer (3) within the wound space between a first boss (71) and a second boss (72) both mounted in the backing layer (3). The tubules contain a dialysate fluid and are in a circuit with a pump (7).
EXAMPLE 4 Cleansing Fe(II) from Aqueous Solution with the Apparatus of FIG. 13: Two-Phase Recirculating Pumped Dressing Containing Liquid Phase Sequestrant (Starch-Desferrioxamine (DFO) Conjugate) An analogue of the apparatus (1) in FIG. 13 was made up, i.e. with a circulating system (wound exudate passes through the cleansing means one or more times in only one direction) with a two-phase means for wound exudate cleansing in which the cleansing phase moves.
The lower chamber, through which cleansing fluid passes, has diagonally opposed inlet and outlet ports, which are opened with needles, connected to a circuit of 5 ml capacity containing a dialysate reservoir and a battery-driven miniature portable diaphragm or peristaltic pump. The circuit contains an aqueous high molecular weight starch�DFO conjugate (5 ml, 4 mg/ml).
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H�nvisningar finns i f�ljande patent citeras i Registreringsdatum Publiceringsdatum S�kande TitelUS8317774 *6 maj 200827 nov 2012Carmeli AdahanSuction systemUS20100063483 *6 maj 200811 mar 2010Carmeli AdahanSuction system* Patentet har citerats av granskarenKlassificeringar USA-klassificering602/41, 604/313, 604/317 Internationell klassificeringA61M35/00, A61F13/00, A61M1/00, A61M3/02, A61M27/00 Kooperativ klassningA61M2205/106, A61M2205/075, A61M2001/0072, A61M27/00, A61M1/0058, A61M2001/009, A61M2205/7518, A61M1/0084, A61M1/0062, A61M3/0229, A61M35/00, A61M1/0088, A61M2205/8206, A61M2001/0068, A61M1/0037 Europeisk klassificeringA61M1/00T2, A61M3/02C, A61M1/00K, A61M1/00T6RoteraOriginalbildGoogles startsida - Webbplatskarta - Massh�mtningar av USPTO - Sekretesspolicy - Anv�ndarvillkor - Om Google Patent - Skicka feedbackDessa data tillhandah�lls av IFI CLAIMS Patent Services©2012 Google