Source: https://patents.google.com/patent/CN103338816B/en
Timestamp: 2019-10-23 19:48:45
Document Index: 195740919

Matched Legal Cases: ['Application No. 13', 'arts 101', 'arts 101', 'arts 101', 'arts 101', 'art 101', 'arts 101', 'art 101', 'arts 101', 'art 101', 'art 101', 'arts 314']

CN103338816B - Forming an energized ophthalmic device and method for a light therapy device - Google Patents
Forming an energized ophthalmic device and method for a light therapy device Download PDF
CN103338816B
CN103338816B CN201280007438.1A CN201280007438A CN103338816B CN 103338816 B CN103338816 B CN 103338816B CN 201280007438 A CN201280007438 A CN 201280007438A CN 103338816 B CN103338816 B CN 103338816B
CN201280007438.1A
CN103338816A (en
W.C.尼莱伊
R.托瓦特
M.皮特斯
W.德林肯伯格
A.米勒蒂
2011-02-04 Priority to US201161439535P priority Critical
2011-02-04 Priority to US61/439535 priority
2012-01-31 Priority to US13/362,275 priority patent/US9446262B2/en
2012-01-31 Priority to US13/362275 priority
2012-02-02 Application filed by 庄臣及庄臣视力保护公司 filed Critical 庄臣及庄臣视力保护公司
2012-02-02 Priority to PCT/US2012/023663 priority patent/WO2012106535A1/en
2013-10-02 Publication of CN103338816A publication Critical patent/CN103338816A/en
2016-10-26 Publication of CN103338816B publication Critical patent/CN103338816B/en
本发明公开了提供眼科镜片(201)的方法和设备，所述眼科镜片具有能够为佩戴者眼睛提供特定带宽的光的光源(202a)。 The present invention discloses a method and apparatus for providing an ophthalmic lens (201), said ophthalmic lens having a light source capable of providing a specific bandwidth for the wearer's eye (202a). 在一些实施例中，眼科镜片(201)由有机硅水凝胶浇铸成型，并且将能量源(202)和光源(202a)封装在所述眼科镜片(201)中。 In some embodiments, an ophthalmic lens (201) cast molding a silicone hydrogel, and the energy source (202) and a light source (202a) of the ophthalmic lens package (201).
形成用于光疗法的通电眼科装置的设备和方法 Forming an energized ophthalmic device and method for a light therapy device
本专利申请要求提交于2011年2月4日的美国临时专利申请61/439,535和提交于2012年1月31日的美国专利申请13/362,275的优先权，所述专利申请的内容是可信的并且以引用方式并入。 This patent application claims priority to U.S. Provisional Patent 2011 February 4 Application 61 / 439,535 and U.S. Patent No. filed on January 31, 2012, Application No. 13 / 362,275, the contents of said patent application is authentic and incorporated by reference.
本发明描述了制造通电的生物医学装置(在一些实施例中更具体地指制造用于光疗法的通电眼科镜片)的方法和设备。 The present invention describes an energized biomedical device fabrication (more specifically refers to the manufacture of a light therapy energized ophthalmic lens in some embodiments) methods and apparatus.
季节性情绪失调(SAD)是一种得到确认的情绪疾病，其中患者在一年中的某个季节经历抑郁症状，最常发生在冬季月份。 Seasonal Affective Disorder (SAD) is a confirmation of mood disorders, in which patients experience depressive symptoms in certain seasons of the year, most often during the winter months. 那些受到SAD影响的患者通常在一年中的大部分时间都有正常的心理健康状态。 Those patients usually have most of the year in a normal state of mental health affected by SAD. SAD的症状可包括但不限于嗜睡、乏力、嗜糖、难以集中注意力和排斥社会活动。 Symptoms of SAD may include, but are not limited to, drowsiness, fatigue, addicted to sugar, difficulty concentrating and exclusive social events. 这些症状导致心情抑郁、绝望、悲观和缺乏愉快感。 These symptoms lead to feelings of depression, hopelessness, pessimism and lack of sense of pleasure.
据信季节性情绪变化与暴露于光的变化有关。 It is believed that the seasonal mood changes and changes related to exposure to light. 白天时间较短、光照强度较弱或长时间阴天的地理区域，诸如北极地区，具有较高的SAD的发生率。 Shorter time of day, light intensity is weak or prolonged cloudy geographic area, such as the Arctic region, having a higher incidence of SAD. 美国内的成年人群中SAD的患病率变化很明显，范围从佛罗里达州和其它阳光明媚的州的较低患病率，到阿拉斯加州、新罕布什尔州和其它北部或阴雨地区的特别高的患病率。 Adult population in the United States in the prevalence of SAD is obvious change, range from a low prevalence is particularly high in Florida and other sunny states, to Alaska, New Hampshire and other northern areas of rain or illness rate.
人们已经对光疗法进行了研究，并将其确立为典型的或冬季相关的季节性情绪失调突出有效的治疗。 Light therapy have been studied, and establish its relevance as a typical seasonal affective disorder, or winter highlight effective treatment. 光疗法采用发出比标准白炽灯明显更多流明的装置。 Emitted using light therapy device significantly more than a standard incandescent lamp lumens. 通常的实施方式包括优选的10,000勒的高亮白全波段光，或任选的2,500勒波长为480nm的蓝光，或350勒波长为500nm的绿光。 2,500 Le Bon length generally preferred embodiments include highlighted segments Bai Quanbo light of 10,000 lux, or optionally to 480nm blue light, or green light 350 Le Bon length of 500nm. 光疗法通常要求患者睁眼坐在离光源规定距离处，时间为每天30至60分钟。 Light therapy typically require the patient to sit eyes predetermined distance from the light source, time 30 to 60 minutes a day. 这种季节性治疗将会持续几个星期直到患者经常暴露在自然光中。 This seasonal treatment will continue for a few weeks until the patient is often exposed to natural light. 大多数患者认为该疗法不方便，并且相当大比例(在某些研究中高达19％)的患者因此停止治疗。 Most patients believe that the therapy is not convenient, and substantial proportion of patients (up to 19% in some studies) thus stopping treatment. 因此需要新的方法和途径以更方便、连续和智能的方式进行光疗法。 Hence the need for new methods and approaches in a more convenient, continuous and intelligent approach to light therapy.
因此，本发明包括用于形成具有进行光疗法的通电部分和光源的生物医学装置(如眼科镜片)的方法和设备。 Accordingly, the present invention comprises a method and apparatus for forming a biomedical device (e.g., ophthalmic lens) is energized and the light source portion of the light therapy. 包括具有光源的通电眼科镜片，形成具有光源的通电眼科镜片的设备及其方法的公开。 It includes a power ophthalmic lens having a light source, a light source having a energization forming the disclosed apparatus and method of the ophthalmic lens. 能量源、光源和其它所需元件可被沉积在第一模具部件和第二模具部件中的一者或二者上，也可将其放入插入物内，而该插入物被沉积在第一模具部件和第二模具部件中的一者或二者上。 An energy source, the light source and other required elements may be deposited on one or both of the first mold part and a second mold part, may be placed in the insert, and the insert is deposited on the first mold part and a second mold part of one or both. 反应性单体混合物被放置在第一模具部件和第二模具部件之间。 Reactive monomer mix is ​​placed between the first mold part and a second mold part. 第一模具部件邻近第二模具部件设置，从而形成镜片腔体，该镜片腔体内具有能量源和光源以及至少一些反应性单体混合物；并且该反应性单体混合物暴露于光化辐射。 A first mold part proximate to the second mold part thereby forming a lens cavity with the lens cavity and a light source having an energy source, and at least some of the reactive monomer mixture; and the reactive monomer mixture is exposed to actinic radiation. 通过控制反应性单体混合物所接触的光化辐射来形成镜片。 A lens formed by controlling the actinic radiation reactive monomer mixture is in contact.
图1示出了根据本发明的一些实施例的模具组件设备。 FIG 1 shows a mold assembly apparatus according to some embodiments of the present invention.
图2示出了包含能量源和元件的眼科镜片。 FIG 2 illustrates an ophthalmic lens comprising an energy source and element.
图3示出了用于将能量源邻近模具部件设置以形成眼科镜片的设备。 FIG 3 shows an energy source disposed adjacent the mold part for an ophthalmic lens to form an apparatus.
图4示出了根据本发明的一些实施例的方法步骤。 Figure 4 illustrates method steps according to some embodiments of the present invention.
图5示出了根据本发明一些其它方面的方法步骤。 FIG. 5 shows some steps of a method according to other aspects of the present invention.
图6示出了可用于实施本发明的一些实施例的处理器。 FIG 6 shows some embodiments of the present invention can be used in the processor of the embodiment.
图7示出了能量源的一些示例性类型，按它们可提供的能量与其体积之比的估计值依次排列。 Figure 7 illustrates some exemplary types of energy source than the estimated value of the energy they provide to its volume sequentially arranged.
图8a-8d示出了能量源的示例性设计形状。 FIGS 8a-8d illustrate an exemplary design of the shape of the energy source.
图9示出了通电眼科镜片的实例，其具有用于再加电的装置和通电元件。 FIG 9 shows an example of an energized ophthalmic lens having a plus electric apparatus and power elements.
图10示出了根据本发明的一些实施例包含光源的通电眼科镜片的横截面视图。 FIG 10 shows a cross-sectional view including a light source in accordance with some embodiments of the present invention in an energized ophthalmic lens.
本发明包括用于形成诸如眼科镜片的生物医学装置的方法和设备。 The present invention comprises a method and apparatus for forming an ophthalmic lens, such as biomedical devices. 具体地讲，本发明包括用于提供其内装配有能量源和光源的眼科镜片的方法和设备。 In particular, the present invention includes providing an ophthalmic lens therein equipped with an energy source and a light source apparatus and methods. 在一些实施例中，本发明包括水凝胶接触镜片，该水凝胶接触镜片包括环绕接触镜片光学区周边的大致环状的区域，其中能量源和元件设置在环绕周边的环状区域。 In some embodiments, the present invention includes a hydrogel contact lenses, hydrogel contact lens which comprises a substantially annular surrounding peripheral optic zone of the contact region, wherein the energy source and the element is disposed around the periphery of the annular region.
以下部分将详细说明本发明的实施例。 The following section embodiments of the invention will be described in detail. 文中描述的优选实施例和可供选择的实施例均仅为示例性实施例，并且应当理解，对于本领域技术人员而言其变化、修改和更改是显而易见的。 Example embodiments and alternative embodiments preferred embodiments described herein are merely exemplary embodiments, and it is understood to those skilled in the art that variations, modifications and alterations will be apparent. 因此，应当了解，所述示例性实施例不对作为其基础的本发明的范围构成限制。 Thus, it should be understood that the scope of the exemplary embodiments of the present invention is not to be construed as limiting as its base.
术语 the term
在涉及本发明的该说明书和权利要求中，所使用的各个术语定义如下： In this specification and claims relate to the present invention, the definition of various terms used are as follows:
元件：如本文所用，是指从能量源中提取电流以执行一种或多种逻辑状态或物理状态变化的装置。 Element: As used herein, refers to draw current from the energy source to perform one or more logical state or physical state change.
通电的：如本文所用，是指能够提供电流或能够在其内储存电能的状态。 Energized: as used herein, refers to the ability to provide current to or to have electrical energy stored within the state.
能量：如本文所用，是指使物理系统做功的能力。 Energy: as used herein, refers to the capacity of a physical system to do work. 本发明中的多种用途可能涉及在做功过程中能够执行电动作的所述能力。 Many uses of the present invention may involve the ability to perform electrical actions in doing work.
能量源：如本文所用，是指能够供能或使生物医学装置处于通电状态的装置。 Energy Source: as used herein, refers to a device capable of energizing or placing a biomedical device in an Energized state.
能量采集器：如本文所用，是指能够从环境中提取能量并将其转化为电能的装置。 Energy Harvesters: as used herein, refers to the ability to extract energy from the environment and convert it to electrical energy.
智能光疗法：如本文所用，是指处理器借以评估不同的数据，并且根据数据分析来动态地对程控的光疗时间表作出补偿调整的进行光疗的方法。 Smart Light Therapy: As used herein, refers to different processors so as to evaluate the data and analysis methods to be dynamically adjusted to compensate for the phototherapy light therapy schedule programmed according to the data. 根据用户在环境光中的暴露调整光疗是智能光疗法的一个实例。 User exposure adjustment according to ambient light is one example of a smart phototherapy light therapy.
镜片：是指位于眼睛内或眼睛上的任何眼科装置。 Lens: refers to any ophthalmic device is located within the eye or on the eye. 这些装置可提供光学矫正或可为美容的。 These devices can provide optical correction or may be cosmetic. 例如，术语镜片可指用于矫正或改进视力或用于增进眼部生理美容(例如虹膜颜色)而不影响视力的接触镜片、眼内镜片、覆盖镜片、眼部插入物、光学插入物或其它类似装置。 For example, the term lens can refer to a vision is corrected or modified, or through which eye physiology to promote cosmetic (e.g. iris color) without affecting the vision of a contact lens, intraocular lens, overlay lens, ocular insert, optical insert or other like. 在一些实施例中，本发明的优选镜片是由硅弹性体或水凝胶制成的软性接触镜片，所述硅弹性体或水凝胶包括但不限于硅水凝胶和氟水凝胶。 In some embodiments, the preferred lenses of the invention are soft contact lenses are made from silicone elastomers or hydrogels, the hydrogel or silicone elastomers include, but are not limited to silicone hydrogels and hydrogel-fluoro .
镜片形成混合物或“反应性混合物”或“RMM”(反应性单体混合物)：如本文所用，是指可固化并交联或可交联形成眼科镜片的单体或预聚物材料。 Lens forming mixture or "reaction mixture" or "the RMM" (reactive monomer mixture): as used herein, refers to a crosslinkable or curable and cross-linking monomer or prepolymer material to form an ophthalmic lens. 各个实施例可包括具有一种或多种添加剂的镜片形成混合物，例如：UV阻挡剂、着色剂、光引发剂或催化剂，以及人们可能想在眼科镜片(例如接触镜片或眼内镜片)中加入的其它添加剂。 Various embodiments may comprise one or more additives having a lens forming mixture, such as: UV blockers, colorants, photoinitiators or catalysts, and one might desire in an ophthalmic lenses (e.g., contact lenses or intraocular lenses) was added other additives.
镜片形成表面：指用于使镜片成形的表面。 Lens Forming Surface: refers to a surface of the lens molding. 在一些实施例中，任何这种表面103-104可具有光特性表面光洁度，其指示所述表面足够光滑并且被形成为使得与成型表面接触的通过镜片形成材料的聚合反应制作的镜片表面是光学合格的。 In some embodiments, any such surface 103-104 can have an optical surface finish properties, indicating that the surface is sufficiently smooth and formed such that the material is formed by polymerization of the lens forming surface making contact with the surface of an optical lens qualified. 此外，在一些实施例中，镜片形成表面103-104可以具有给镜片表面赋予期望的光学特性所必需的几何形状，包括(但不限于)球面、非球面以及柱面度数、波前像差矫正、角膜形貌学校正等，以及它们的任何组合。 Further, in some embodiments, the lens forming surface 103-104 can have a geometry imparting desired optical characteristics to the lens surface required, including (but not limited to) spherical, aspherical and cylinder power, wave front aberration correction , corneal topography correction and the like and any combination thereof.
光源：如本文所用，是指能够发光的装置。 Source: as used herein, refers to a device capable of emitting light.
光疗法：如本文所用，是指暴露于用不同装置控制、以特定的强度施用规定量的时间(并且在某些情况下为一天的特定时间)的特定波长的光中。 Light Therapy: As used herein, refers to exposure to different control means, a predetermined amount of time to the administration of a particular intensity (and in some cases for a particular time of day) in the light of a specific wavelength.
锂离子电池：指其中锂离子移动通过电池以产生电能的电化学电池。 Lithium Ion Cell: refers to a battery in which lithium ions move through an electrochemical cell to generate electrical energy. 这种通常称之为电池的电化学电池可以其典型形式重新通电或重新充电。 Such electrochemical battery cells typically referred to its typical form may be reenergized or recharged.
勒：如本文所用，是指国际单位制(SI)中照度的单位。 Le: As used herein, refers to a unit of the International System of Units (SI) in illuminance. 勒测定的是单位面积的光通量。 Le assay is the luminous flux per unit area. 1勒等于1流明的光通量均匀分布于1平方米面积上的照度。 Le is equal to 1 1 Lumen uniformly distributed over an area of ​​one square meter of illumination. 这也相当于所有点均距一个国际烛光的点光源一米远的表面上将存在的照度。 This corresponds to a mean distance of all points of illumination candela point light source on a surface of meters exist. 1勒等于0.0929英尺烛光。 1 Le equal to 0.0929 feet candlelight.
模具：指可用于将未固化制剂形成镜片的刚性或半刚性的物体。 Mold: refers to a formulation that can be used to form an uncured rigid or semi-rigid object lens. 一些优选的模具包括形成前曲面模具部件和后曲面模具部件的两个模具部件。 Some preferred molds include two mold parts forming a front curve mold part and a back curve mold part.
光学区：如本文所用，是指眼科镜片的佩戴者通过其观看的眼科镜片的区域。 Optical Zone: as used herein, refers to an ophthalmic lens wearer is viewed through the region of its ophthalmic lens.
功率：如本文所用，是指每单位时间内所做的功或所传递的能量。 Power: as used herein refers to work done per unit of time or the energy delivered.
程控的光疗时间表：如本文所用，是指根据变量诸如日期、地理区域和用户的季节性情绪失调症状的严重性控制光疗法的时间选择、持续时间和强度的一组自动指令。 Programmed light therapy schedule: As used herein, refers to the control according to variables such as the severity of the date light therapy, the symptoms of seasonal affective disorder and geographical area of ​​the user selected time, a set of instructions to automatically duration and intensity. 程控的光疗时间表可由眼部护理专业人员、医师或使用者设定。 Programmed light therapy schedule set by eye care professionals, physicians or users.
可再充电或可再加电：如本文所用，是指恢复到具有更大做功本领的状态的能力。 Rechargeable or Re-energizable: as used herein, refers to the ability to return to a state with higher capacity to do work in. 本发明范围内的多种用途可与能够在特定的恢复时间周期内使电流以特定速率流动的恢复能力相关。 Many uses within this invention may relate to a current within a certain period of recovery time at a specific flow rate of recovery.
再加电或再充电：恢复到具有更大做功本领的状态。 Plus or Recharge: return to a state with higher capacity to do work. 本发明范围内的多种用途可与能够使装置在特定的恢复时间周期内使电流以特定速率流动的恢复能力相关。 Many uses within this invention may relate to restoring a device to the capability to flow a current at a certain rate within a certain period of recovery time.
脱离模具：意指镜片完全从模具分离或只是松散地附着使得其可通过药签轻柔地搅拌或推动而取下。 Removed from the mold: means that a lens is completely separated from the mold, or is only loosely attached so that it can be stirred from or pushed gently removed by a swab.
季节性情绪失调(SAD)：如本文所用，是指发生在暴露于阳光时间有限的季节的情绪疾病，特征为具有抑郁的症状，并且随着春天的到来或通过光疗法可以减轻。 Seasonal Affective Disorder (SAD): As used herein, refers to having symptoms of depression occurred in a limited exposure to sunlight time seasonal mood disorders, wherein, with the arrival of spring and can be reduced by light or therapy. 通常认为人们在冬季经历的抑郁的复发性状态与缺乏日光有关。 It is generally considered the winter experience recurrent state of depression and lack of sunlight related.
使用嵌入式能量源109的通电镜片100可包括用作能量存储装置的电化学电池或者说电池，在一些实施例中，将构成能量源的材料密封并隔离于其内设有眼科镜片的环境。 Using the embedded energy source 109 is energized lens 100 may include a battery as an electrochemical energy storage device or battery, in some embodiments, the energy source of the material constituting the spacer and sealing features thereon environment ophthalmic lens.
在一些实施例中，电路和能量源109可以位于镜片佩戴者可看到的光学区之外，而在另一些实施例中所包含的导电材料可以位于光学区之内或之外，因为此导体材料足够小，不会对接触镜片佩戴者的视野产生不利影响。 In some embodiments, the energy source, and circuitry 109 may be located outside the optical area of ​​the lens wearer can be seen, while in other embodiments the conductive material contained within the optical region may be located in or outside, because the conductor material small enough not to adversely affect the contact lens wearer's field of vision.
通常，根据本发明的一些实施例，能量源通过自动化技术嵌入眼科镜片中，该自动化技术将能量源109放置在与用于制备镜片的模具部件相应的所需位置。 Typically, in accordance with some embodiments of the present invention, the energy source through automation technology into an ophthalmic lens, the automation of the energy source 109 is placed in the mold corresponding to a lens means for preparing a desired position.
在一些实施例中，能量源109被设置为与某元件电连通，该元件可按指令启动并从包含在眼科镜片内的能量源109中提取电流。 In some embodiments, the energy source 109 is arranged to communicate electrically with an element, the element can be started and an instruction from the energy contained within the ophthalmic lens in the current source 109 is extracted. 元件108可包括例如半导体装置、有源或无源电气装置或电动机械，包括例如：微机电机械(MEMS)、纳机电机械(NEMS)或微机械。 Element 108 may comprise, for example, a semiconductor device, active or passive electrical or electromechanical means, for example, comprising: a micro-electromechanical machines (the MEMS), nanoelectromechanical machine (the NEMS) or micromechanical. 在一些实施例中，半导体或有源或无源电气装置可包括肉眼可看到的显示器。 In some embodiments, a semiconductor, or active or passive electrical device may comprise a display visible to the naked eye. 在设置能量源和元件之后，反应性混合物可通过模具部件成型并聚合形成眼科镜片。 After setting member and the energy source, the reaction mixture may be shaped by the mold part and polymerized to form the ophthalmic lens.
现在参见图1，示出了包含能量源109和光源109a的眼科镜片的示例性模具100的示意图。 Referring now to FIG. 1, it shows a schematic view of an ophthalmic lens comprises an energy source 109 and a light source 109a of an exemplary mold 100. 如本文所用，术语模具包括单件或多件式装置100，该装置具有可将镜片形成混合物分配于其中的腔体105，使得当镜片形成混合物反应或固化后产生所需形状的眼科镜片。 As used herein, the term mold comprises a single piece or multi-piece apparatus 100, the apparatus having a lens may be formed to produce an ophthalmic lens of a desired shape after the mixture was partitioned cavity 105 therein, such that when the reaction or cure of the lens forming mixture. 本发明的模具和模具组件100由不止一个“模具部件”或“模具件”101-102构成。 The molds and mold assemblies 100 of this invention consists of more than one "mold parts" or "mold pieces" 101-102. 可将模具部件101-102组合在一起，这样在模具部件101-102之间形成腔体105，镜片可在此腔体内形成。 The mold parts 101-102 can be brought together such that a cavity 105 is formed, a lens can be formed in this cavity between the mold parts 101-102. 优选地，模具部件101-102的这种组合是暂时的。 Preferably, such a combination of mold parts 101-102 is temporary. 镜片形成后，可以再次分离模具部件101-102，以取下镜片。 After the formation of the lens mold parts 101-102 can again be separated for removal of the lens.
至少一个模具部件101-102使其表面103-104的至少一部分与镜片形成混合物接触，使得镜片形成混合物反应或固化后，表面103-104使与其接触的镜片部分具有所需的形状和形式。 101-102 so that the at least one surface of the mold member at least a part of the mixture is contacted with lenses 103-104, such reaction or cure of the lens forming mixture, so that its surface 103-104 in contact with the lens portion having a desired shape and form. 对于至少一个其它模具部件101-102也是如此。 At least one other mold part 101-102.
因此，例如，在一个优选实施例中，模具组件100由两个部件101-102形成，即凹形件(前件)102和凸形件(后件)101，二者之间形成腔体。 Thus, for example, in a preferred embodiment, the die assembly 100 from two parts 101-102, a female concave piece (front piece) 102 and a male convex piece (back piece) 101 with a cavity formed therebetween. 凹形表面104与镜片形成混合物接触的部分具有要在模具组件100中生产的眼科镜片的前曲面的曲率，而且足够光滑并被形成为使得通过聚合与凹形表面104接触的镜片形成混合物而形成的眼科镜片的表面是光学上合格的。 With the concave surface portion 104 of the contact lens forming mixture has the curvature to the front curve of the ophthalmic lens produced in the mold assembly 100, and sufficiently smooth and formed so that a lens by polymerization in contact with the concave surface 104 is formed to form a mixture ophthalmic lens surface is optically acceptable.
在一些实施例中，前模具件102还可以具有围绕圆形周围边缘并与其成一整体的环状凸缘，且前模具件102在垂直于轴并从凸缘延伸的平面内从凸缘延伸(未示出)。 In some embodiments, the front mold piece 102 can also have rounded edges and around the circumference of its integral annular flange, and the front mold member 102 extends from the flange in a plane perpendicular to the axis and extending from the flange ( not shown).
镜片形成表面可包括表面103-104，所述表面具有光学特性表面光洁度，其指示所述表面足够光滑并且被形成为使得与成型表面接触的通过镜片形成材料的聚合反应制作的镜片表面是光学合格的。 Lens forming surface 103-104 can comprise a surface, said surface having a surface finish of the optical properties, indicating that the surface is sufficiently smooth and formed such that the surface of the lens produced by the polymerization of a lens forming material in contact with the molding surface is optically qualified of. 此外，在一些实施例中，镜片形成表面103-104可以具有给镜片表面赋予期望的光学特性所必需的几何形状，包括(但不限于)球面、非球面以及柱面度数、波前像差矫正、角膜形貌学校正等，以及它们的任何组合。 Further, in some embodiments, the lens forming surface 103-104 can have a geometry imparting desired optical characteristics to the lens surface required, including (but not limited to) spherical, aspherical and cylinder power, wave front aberration correction , corneal topography correction and the like and any combination thereof.
在111处，示出了一种可以将能量源109和光源109a设置于其上的介质。 At 111, it shows a possible energy source 109 and a light source 109a disposed thereon medium. 介质111可为其上可设置能量源109和光源109a的任何接纳材料，在一些实施例中还可包括电路路径、元件108以及用于使用能量源的其它方面。 Medium 111 may be any receiving material may be disposed on the power source 109 and a light source 109a, for, in some embodiments, may further include circuit paths, components and other aspects of 108 using the energy source. 在一些实施例中，介质111可以是在镜片形成时可被掺入到镜片中的材料的透明涂层。 In some embodiments, medium 111 may be a transparent coating material be incorporated into the lens when the lens is formed. 透明涂层可包含例如如下所述的颜料、单体或其它生物相容性材料。 Clear coat may contain a pigment, a monomer or other biocompatible materials, for example, as described below. 另外的实施例可包括包含插入物的介质，而插入物可以为刚性的或可成形的。 Further embodiments may include a media comprising an insert, and the insert may be a rigid or formable. 在一些实施例中，刚性插入物可包括提供光学性质(例如用于视力矫正的那些性质)的光学区和非光学区部分。 In some embodiments, a rigid insert may include providing an optical properties (e.g., for vision correction for those properties) of the optical zone and non-optical zone portion. 可将能量源109设置在该插入物的光学区和非光学区中的一者或二者上。 The energy source 109 may be disposed on the optical zone of the insert and non-optical regions of one or both. 再有一些实施例可包括可为刚性或可成形的环状插入物、或围绕使用者透过而观看的光学区的某些形状。 Still other embodiments may comprise a rigid insert forming or cyclic, or some shape around the optical region of the user through the viewing.
各种实施例还包括将能量源109和光源109a设置在该插入物上，然后将插入物设置在用于形成镜片的模具部分内。 Various embodiments further comprise an energy source 109 and a light source 109a disposed on the insert, and the insert is disposed in a mold for forming the lens portion. 介质111还可以包括这样的插入物，其具有一个或多个能通过能量源109接受电荷的元件108。 Medium 111 may also include an insert, having one or more energy source 109 can receive an electrical charge element 108.
模具部件101-102材料可包括例如：一种或多种下列物质的聚烯烃：聚丙烯、聚苯乙烯、聚乙烯、聚甲基丙烯酸甲酯，以及改性的聚烯烃。 Mold part 101-102 material can include, for example: a polyolefin of one or more of the following materials: polypropylene, polystyrene, polyethylene, polymethyl methacrylate, and modified polyolefins. 其它模具可包括陶瓷或金属材料。 Other molds can include a ceramic or metallic material.
优选的脂环烃共聚物包含两种不同的脂环烃聚合物，由日本瑞翁公司(Zeon Chemicals LP)以商品名为ZEONOR销售。 Preferred alicyclic hydrocarbon copolymer comprises two different alicyclic hydrocarbon polymer by Zeon Corporation (Zeon Chemicals LP) sold under the trade name ZEONOR. 存在几种不同等级的ZEONOR。 There are several different levels of ZEONOR. 不同的等级可具有范围从105℃到160℃的玻璃化转变温度。 It may have different levels range from glass transition temperature to 160 ℃ of 105 ℃. 特别优选的材料为ZEONOR1060R。 Particularly preferred material is ZEONOR1060R.
可与一种或多种添加剂组合以形成眼科镜片模具的其它模具材料包括例如Zieglar-Natta聚丙烯树脂(有时称为znPP)。 Other mold materials may be combined with one or more additives to form an ophthalmic lens mold include, for example, Zieglar-Natta polypropylene resins (sometimes referred to as znPP).
在一些实施例中，本发明的模具还可以包含诸如聚丙烯、聚乙烯、聚苯乙烯、聚甲基丙烯酸甲酯、主链上含脂环部分的改性聚烯烃以及环状聚烯烃的聚合物。 In some embodiments, the mold of the present invention may further comprise a polymerization such as polypropylene, polyethylene, polystyrene, polymethyl methacrylate, modified polyolefins containing an alicyclic moiety in the main chain and cyclic polyolefins thereof. 这种共混物可用于任何一半或两半模具上，其中优选的是将这种共混物用于后曲面，而前曲面包含脂环族共聚物。 This blend can be used on any half or mold halves, where it is preferable that this blend is used on the back curve and the front curve consists of the alicyclic copolymers.
在根据本发明制备模具100的一些优选方法中，按照已知的技术采用注射成型，然而，各实施例也可以包括通过其它技术制作的模具，这些技术包括例如自由形态成型、车床加工、金刚石车削或激光切割。 In some preferred methods of making molds 100 according to the present invention, according to known injection molding techniques, however, embodiments can also include molds produced by other techniques, such techniques include, for example, free-form molding, lathing, diamond turning or laser cutting.
镜片通常在两个模具部件101-102的至少一个表面上形成。 Typically, lenses are formed on at least one surface of both mold parts 101-102. 然而，在一些实施例中，镜片的一个表面可由模具部件101-102形成，镜片的另一个表面可以用车床加工方法或其它方法形成。 However, in some embodiments, it may be a surface of a lens mold part 101-102 and another surface of a lens can be formed using a lathing method, or other methods.
镜片 lens
现在参见图2，示出了包含能量源202、光源202a和元件203的眼科镜片201。 Referring now to FIG. 2, it shows an ophthalmic lens 201 comprises an energy source 202, a light source element 203 and 202a.
能量源202可以与光源202a和元件203电连通。 Energy source 202 may be in communication with the power source 203 and the element 202a. 光源202a可以包含发光二极管(LED)或其它可以发出波长为450至500纳米，更优选470至480纳米以及2,000至3,000勒的蓝光的光源。 The light source 202a may comprise a light emitting diode (LED) or other may emit wavelengths of 450 to 500 nm, more preferably blue light from 470 to 480 nanometers and 2,000 to 3,000 lux. 或者，LED或其它光源可以发出波长为475至525纳米，更优选490至510纳米以及300至400勒的绿光。 Alternatively, LED or other light source may emit a wavelength of 475-525 nm, more preferably 490 to 510 nanometers and 300 to 400 lux green. 在另一个实施例中，可以将单独的光源输送到眼科镜片201中的一个或多个位置以提供照明。 In another embodiment, a separate light source may be delivered to a ophthalmic lens 201 or a plurality of positions to provide illumination. 元件203可包括能对电荷作出响应而发生状态变化的任何装置，例如：半导体型芯片、无源电气装置光学装置(例如水晶透镜)；处理器、微机电机械(MEMS)或纳机电机械(NEMS)。 Element 203 may include a charge can be made to respond to any change in state means occur, for example: a semiconductor type chip, a passive electrical device optics (e.g. quartz lens); a processor, a micro-electromechanical machines (MEMS) or nano electromechanical machinery (NEMS ).
在一些具体的实施例中，元件203包括蓄电装置，例如电容器、超大容量电容器、超级电容器或其它蓄电元件。 In some embodiments, the element 203 includes a power storage device, such as a capacitor, ultracapacitor, supercapacitor, or other storage element. 能量源202可以包括例如：位于视区之外、眼科镜片周边中的锂离子电池，它可通过进入能量源202的射频、光伏电池和磁感中的一者或多者充电。 Energy source 202 may comprise, for example: viewing zone located outside the periphery of an ophthalmic lens in a lithium ion battery, which can be charged by the RF energy source into the photovoltaic cell 202, and magnetic induction in the one or more. 结合下列图7进一步讨论其它能量源202。 7 is further discussed below in conjunction with FIG other energy source 202.
如图所示，在一些实施例中，能量源部分202、光源202a和元件203位于光学区204之外，其中光学区204包括镜片201的为镜片201佩戴者提供可视通路的部分。 As shown, in some embodiments, the energy source portion 202, a light source 202a and the optical element 203 is located outside the area 204, wherein the optic zone 204 comprises a portion for providing a visual path of the lens 201 of the lens 201 of a wearer. 其它实施例可包括位于眼科镜片的光学区部分中的能量源202。 Other embodiments may include an energy source is an ophthalmic lens optical zone portion 202. 例如，此类实施例可包括由导电粒子形成的能量源202，其中导电粒子非常小，单凭肉眼无法看见。 For example, such embodiments may include an energy source formed by the conductive particles 202, wherein conductive particles are very small, not visible to the naked eye alone.
在一些实施例中，优选的镜片类型可包括具有含有机硅的组分的镜片201。 In some embodiments, a preferred lens type can include a lens 201 having a silicon-containing component. “含有机硅的组分”是指在单体、大分子单体或预聚物中含至少一个[-Si-O-]单元的组分。 "Silicone-containing component" refers to containing at least one [-Si-O-] unit in a monomer, macromer or prepolymer. 优选地，以含有机硅的组分的总分子量计，所有Si和所连接的O在含有机硅的组分中的含量大于约20重量％，还更优选地大于30重量％。 Preferably, the total molecular weight of the silicone-containing component terms of all of the Si and attached O are present in the silicone-containing component content of greater than about 20% by weight, still more preferably greater than 30 wt%. 可用的含有机硅的组分优选地包含可聚合的官能团，例如丙烯酸酯、甲基丙烯酸酯、丙烯酰胺、甲基丙烯酰胺、乙烯基、N-乙烯基内酰胺、N-乙烯基酰胺和苯乙烯基官能团。 Preferably the components can comprise a silicon-containing polymerizable functional group such as acrylate, methacrylate, acrylamide, methacrylamide, vinyl, N- vinyl lactam, N- vinylamide, and benzene vinyl functional groups.
合适的含有机硅的组分包括由式I表示的化合物 Suitable silicone containing components include compounds represented by Formula I
R 1独立地选自一价活性基团、一价烷基或一价芳基，上述任何基团还可以包含选自羟基、氨基、氧杂、羧基、烷基羧基、烷氧基、酰胺基、氨基甲酸酯基、碳酸酯基、卤素或它们的组合的官能团；和含有1至100个Si-O重复单元的一价硅氧烷链，所述重复单元还可以包含选自烷基、羟基、氨基、氧杂、羧基、烷基羧基、烷氧基、酰氨基、氨基甲酸酯基、卤素或它们的组合的官能团； R 1 is independently selected from monovalent reactive groups, monovalent alkyl groups, or monovalent aryl groups, any of the foregoing groups may further comprise functionality selected from hydroxy, amino, oxa, carboxy, alkyl carboxy, alkoxy, amido , functional urethane groups, carbonate, halogen or combinations thereof; and containing 1 to 100 repeating Si-O units a monovalent siloxane chain, the repeating unit may further comprise functionality selected from alkyl, hydroxy, amino, oxa, carboxy, alkyl carboxy, alkoxy, amido, carbamate functional groups, halogen or combinations thereof;
其中b＝0至500，其中应当理解，当b不为0时，b为众数等于指定值的分布； Where b = 0 to 500, where it is understood that when b is other than 0, b is equal to a mode value of the distribution of assigned;
其中至少一个R 1包含一价反应性基团，并且在一些实施例中，1至3个R 1包含一价反应性基团。 Wherein at least one R 1 comprises a monovalent reactive group, and in some embodiments, 1-3 R 1 comprises a monovalent reactive group.
如本文所用，“一价反应性基团”为可经历自由基和/或阳离子聚合的基团。 As used herein, "monovalent reactive group" can undergo free radical and / or cationic polymerizable groups. 自由基反应性基团的非限制性例子包括(甲基)丙烯酸酯、苯乙烯基、乙烯基、乙烯基醚、C 1-6烷基(甲基)丙烯酸酯、(甲基)丙烯酰胺、C 1-6烷基(甲基)丙烯酰胺、N-乙烯基内酰胺、N-乙烯基酰胺、C 2-12烯基、C 2-12烯基苯基、C 2-12烯基萘基、C 2-6烯基苯基、C 1-6烷基、O-乙烯基氨基甲酸酯以及O-乙烯基碳酸酯。 Non-limiting examples of free radical reactive groups include (meth) acrylate, styryl, vinyl, vinyl ethers, C 1-6 alkyl (meth) acrylate, (meth) acrylamide, C 1-6 alkyl (meth) acrylamide, N- vinyl lactam, N- vinylamide, C 2-12 alkenyl group, C 2-12 alkenyl, phenyl, C 2-12 alkenyl naphthyl , C 2-6 alkenyl, phenyl, C 1-6 alkyl, O- vinylcarbamates and O- vinylcarbonates. 阳离子反应性基团的非限制性例子包括乙烯基醚或环氧基以及它们的混合物。 Non-limiting examples of cationic reactive groups include vinyl ethers or epoxide groups and mixtures thereof. 在一个实施例中，自由基活性基团包括(甲基)丙烯酸酯、丙烯酰氧基、(甲基)丙烯酰胺、以及它们的混合物。 In one embodiment the free radical reactive groups include (meth) acrylate, acryloxy, (meth) acrylamide, and mixtures thereof.
合适的一价烷基和芳基包括未取代的一价C 1 -C 16烷基、C 6 -C 14芳基，诸如取代的和未取代的甲基、乙基、丙基、丁基、2-羟丙基、丙氧基丙基、聚乙烯氧丙基、它们的组合等。 Suitable monovalent alkyl and aryl groups include unsubstituted monovalent C 1 -C 16 alkyl, C 6 -C 14 aryl group, such as substituted and unsubstituted methyl, ethyl, propyl, butyl, 2-hydroxypropyl, propoxypropyl, polyethylene oxopropyl, combinations thereof and the like.
在一个实施例中，b为0，一个R 1为一价反应性基团，并且至少3个R 1选自具有1至16个碳原子的一价烷基，在另一个实施例中，选自具有1至6个碳原子的一价烷基。 In one embodiment, b is 0, R 1 is a monovalent reactive group, and at least three R 1 is selected monovalent alkyl group having 1 to 16 carbon atoms, in another embodiment, is selected from from monovalent alkyl groups having 1 to 6 carbon atoms. 本实施例的有机硅组分的非限制性例子包括2-甲基-2-羟基-3-[3-[1，3，3，3-四甲基-1-[(三甲基甲硅烷基)氧基]二硅氧烷基]丙氧基]丙酯(“SiGMA”)、2-羟基-3-甲基丙烯酰氧基丙氧基丙基-三(三甲基甲硅烷氧基)硅烷、3-甲基丙烯酰氧基丙基三(三甲基甲硅烷氧基)硅烷(“TRIS”)、3-甲基丙烯酰氧基丙基双(三甲基甲硅烷氧基)甲基硅烷以及3-甲基丙烯酰氧基丙基五甲基二硅氧烷。 Non-limiting examples of silicone components of this embodiment include 2-methyl-2-hydroxy-3- [3- [1,3,3,3-tetramethyl-1 - [(trimethylsilyl yl) oxy] disiloxanyl] propoxy] propyl ester ( "SiGMA"), 2- hydroxy-3-methacryloyloxy-propoxy-propyl - tris (trimethyl siloxy ) silane, 3-methacryloxypropyl tris (trimethylsiloxy) silane ( "TRIS"), 3- methacryloxy-propyl bis (trimethyl siloxy) methylsilane and 3-methacryloxypropyl pentamethyl disiloxane.
在另一个实施例中，b为2至20、3至15，或者在一些实施例中为3至10；至少一个末端R 1包含一价反应性基团，其余的R 1选自具有1至16个碳原子的一价烷基，在另一个实施例中，选自具有1至6个碳原子的一价烷基。 In another embodiment, b is 2 to 20, 3 to 15, or in some embodiments 3 to 10; at least one terminal R 1 comprises a monovalent reactive group, the remaining R 1 is selected having 1 to a monovalent 16 carbon atoms, in embodiments, is selected from a monovalent alkyl group having 1 to 6 carbon atoms in another embodiment. 在另一个实施例中，b为3至15，一个末端R 1包含一价反应性基团，另一个末端R 1包含具有1至6个碳原子的一价烷基并且剩余的R 1包含具有1至3个碳原子的一价烷基。 In another embodiment, b is 3 to 15, one terminal R 1 comprises a monovalent reactive group, the other terminal R 1 comprises a monovalent alkyl group having 1 to 6 carbon atoms and the remaining R 1 comprises having a monovalent alkyl of 1 to 3 carbon atoms. 本实施例的有机硅组分的非限制性例子包括(单-(2-羟基-3-甲基丙烯酰氧基丙基)-丙醚封端的聚二甲基硅氧烷(分子量为400-1000)(“OH-mPDMS”)、单甲基丙烯酰氧基丙基封端的单正丁基封端的聚二甲基硅氧烷(分子量为800-1000)(“mPDMS”)。 Non-limiting examples of silicone components of this embodiment include (mono - (2-hydroxy-3-methacryloxypropyl) - propyl ether terminated polydimethylsiloxane (molecular weight of from 400 to 1000) ( "OH-mPDMS"), monomethyl methacryloxypropyl terminated mono-n-butyl terminated polydimethylsiloxane (molecular weight 800-1000) ( "mPDMS").
在另一个实施例中，b为5至400或10至300，两个末端R 1均包含一价反应性基团并且剩余的R 1独立地选自具有1至18个碳原子的一价烷基，所述一价烷基在碳原子之间可具有醚键并且还可包含卤素。 In another embodiment, b is 5 to 400 or from 10 to 300, two terminal R 1 comprises a monovalent reactive group and the remaining R 1 is independently selected from monovalent alkyl having 1 to 18 carbon atoms, group, a monovalent alkyl groups between carbon atoms which may have ether bond and may further comprise halogen.
在一个需要有机硅水凝胶镜片的实施例中，本发明的镜片将由反应性混合物制成，其中基于据以制备聚合物的活性单体组分的总重量计，反应性混合物包含至少约20重量％的含有机硅的组分，优选地在约20重量％至70重量％之间。 In an embodiment requires a silicone hydrogel lenses, the lenses of the invention will be made of the reaction mixture, wherein the data based on the total weight of reactive monomer components for preparing a polymer, the reactive mixture comprises at least about 20 % by weight of the silicone-containing component, preferably between 70 wt% to about 20% by weight.
在另一个实施例中，1至4个R 1包含乙烯基碳酸酯或如下式所示的乙烯基氨基甲酸酯： In another embodiment, the vinyl, 1-4 R 1 comprises shown vinyl carbonate or carbamate of the formula:
式II Type II
R代表氢或甲基；d为1、2、3或4；并且q为0或1。 R represents hydrogen or methyl; d is 3 or 4; and q is 0 or 1.
含有机硅的乙烯基碳酸酯或乙烯基氨基甲酸酯单体具体包括：1，3-双[4-(乙烯氧基羰基氧基)丁-1-基]四甲基-二硅氧烷；3-(乙烯氧基羰基硫基)丙基-[三(三甲基甲硅烷氧基)硅烷]；3-[三(三甲基甲硅烷氧基)甲硅烷基]丙基烯丙基氨基甲酸酯；3-[三(三甲基甲硅烷氧基)甲硅烷基]丙基乙烯基氨基甲酸酯；碳酸三甲基甲硅烷基乙基乙烯酯；碳酸三甲基甲硅烷基甲基乙烯酯；以及 Vinyl carbonate or vinyl carbamate monomers specifically include silicone containing: 1,3-bis [4- (vinyloxy carbonyloxy) butan-1-yl] tetramethyl - disiloxane ; 3- (vinyloxy carbonyl) propyl - [tris (trimethylsiloxy) silane]; 3- [tris (trimethylsiloxy) silyl] propyl allyl carbamate; 3- [tris (trimethylsiloxy) silyl] propyl vinyl carbamate; carbonate, trimethyl silyl ethyl vinyl carbonate; trimethylsilyl group ethylene methyl ester; and
在期望生物医疗装置的模量在约200以下的情况中，只有一个R 1应包含一价反应性基团，并且剩余的R 1基团中不超过两个将包含一价硅氧烷基团。 In a desired modulus of biomedical devices in the case of about 200 or less, only one of R 1 shall comprise a monovalent reactive group and the remaining R 1 groups will contain no more than two monovalent siloxane groups .
另一类含有机硅组分包括以下式的聚氨酯大分子单体： Another class of silicone-containing components includes polyurethane macromers of the following formulas:
(*D*A*D*G) a *D*D*E 1 ； (* D * A * D * G) a * D * D * E 1;
E(*D*G*D*A) a *D*G*D*E 1或； E (* D * G * D * A) a * D * G * D * E 1 or;
E(*D*A*D*G) a *D*A*D*E 1 E (* D * A * D * G) a * D * A * D * E 1
D代表具有6至30个碳原子的烷二基、烷基环烷二基、环烷二基、芳二基或烷基芳二基， D represents an alkanediyl group having 6 to 30 carbon atoms, cycloalkyl alkyl group, cycloalkyl group, aryl group or alkylaryl two-diyl,
G代表具有1至40个碳原子并且主链中可包含醚键、硫代键或胺键的烷二基、环烷二基、烷基环烷二基、芳二基或烷基芳二基； G represents having 1 to 40 carbon atoms and may comprise a main chain alkanediyl group an ether bond, an amine bond bond or thio, cycloalkyl group, alkyl cycloalkyl group, aryl group or alkylaryl two-diyl ;
A代表下式的二价聚合基团： A 'represents the divalent radical polymerization:
式VII Type VII
R 11独立地代表具有1至10个碳原子并且碳原子之间可以包含醚键的烷基或氟代烷基；y为至少1；并且p提供400至10,000的部分重量；E和E 1的每一个独立地代表可聚合的不饱和有机基，其用下式表示： R 11 independently represents a 1 to 10 carbon atoms and may contain ether linkages between alkyl or fluoroalkyl carbon atoms; Y is at least 1; and p provides part by weight of 400 to 10,000; E and E 1 of each independently represent a polymerizable unsaturated organic radical, which is represented by the formula:
式VIII Formula VIII
其中：R 12为氢或甲基；R 13为氢、具有1至6个碳原子的烷基，或-CO-YR 15基，其中Y为-O-、YS-或-NH-；R 14为具有1至12个碳原子的二价基；X代表-CO-或-OCO-；Z代表-O-或-NH-；Ar代表具有6至30个碳原子的芳基；w为0至6；x为0或1；y为0或1；并且z为0或1。 Wherein: R 12 is hydrogen or methyl; R 13 is hydrogen, alkyl having 1 to 6 carbon atoms, or a -CO-YR 15 group wherein Y is -O-, YS-, or -NH-; R 14 is a divalent group having 1 to 12 carbon atoms; X is -CO- or representatives -OCO-; Z represents -O- or -NH-; Ar represents an aryl group having 6 to 30 carbon atoms; W is 0 to 6; x is 0 or 1; y is 0 or 1; and z is 0 or 1.
优选的含有机硅的组分是由如下式表示的聚氨酯大分子单体： The preferred silicone-containing component is a polyurethane macromer represented by the following formula:
式IX Formula IX
其中R 16为移除异氰酸酯基团后的二异氰酸酯的双基，例如异佛尔酮二异氰酸酯的双基。 Wherein R 16 is a diradical of a diisocyanate after removal of the isocyanate group, for example, heterobifunctional group isophorone diisocyanate. 其它合适的含有机硅的大分子单体为由氟醚、羟基封端的聚二甲基硅氧烷、异佛尔酮二异氰酸酯和甲基丙烯酸异氰基乙酯反应形成的式X的化合物(其中x+y为在10至30范围内的数值)。 Other suitable silicone containing macromer by fluoroether, hydroxy-terminated polydimethylsiloxane, isophorone diisocyanate, and isocyanate ethyl methacrylate, formed by the reaction of a compound of formula X ( wherein x + y is a number in the range of 10 to 30).
式X Formula X
其它适合用于本发明的含有机硅的组分包括包含聚硅氧烷基团、聚亚烷基醚基团、二异氰酸酯基团、多氟化烃基团、多氟化醚基团和多糖基团的大分子单体；具有极性氟化接枝或侧基、有氢原子连接到末端二氟代碳原子的聚硅氧烷；含醚键和硅氧烷键的亲水性硅氧烷基甲基丙烯酸酯以及含聚醚基团和聚硅氧烷基团的可交联单体。 Other silicone containing components suitable for the present invention include polysiloxane group, polyalkylene ether groups, ester groups diisocyanate, polyfluorinated hydrocarbon group, polyfluorinated ether and polysaccharide groups group hydrophilic ether bond-containing siloxane and a siloxane bond; macromer group; with a polar fluorinated graft or side group having a hydrogen atom attached to a terminal difluoro-substituted polysiloxanes carbon atoms, methyl acrylate, and polyether group-containing polysiloxane group and a crosslinkable monomer. 也可用任一前述的聚硅氧烷作为本发明中的含有机硅的组分。 Any of the foregoing may also be used as the silicone in the silicone-containing component of the present invention.
以下方法步骤作为可以根据本发明的一些方面实施的方法的例子来提供。 The following method steps may be provided as an example of embodiment of the method of some aspects of the invention. 应当理解，方法步骤的叙述顺序并不具有限制性，也可以使用其它顺序实施本发明。 It will be appreciated that the order of method steps is not limiting, embodiment of the present invention may also be used other sequences. 此外，并非所有步骤都是实施本发明所必需的，本发明的各个实施例中可包括其它步骤。 In addition, not all steps are necessary for the present invention, various embodiments of the present invention may include other steps.
现在参见图4，流程图示出了可用于实施本发明的示例性步骤，在步骤401，能量源和光源设置在介质上。 Referring now to FIG. 4, a flowchart illustrates exemplary steps may be used in the practice of the present invention, in the step 401, the energy source and a light source disposed media. 介质可以含有也可以不含有一个或多个元件。 Medium may contain or may not contain one or more elements.
在步骤402，可将反应性单体混合物沉积在模具部件101-102中。 In step 402, the reactive monomer mix can be deposited in the mold part 101-102.
在步骤403，将介质设置在模具部件内。 In step 403, the medium disposed in the mold member. 在一些优选的实施例中，通过机械放置将介质放置到模具部件中。 In some preferred embodiments, the medium is placed by mechanical placement into the mold part. 机械放置可包括例如机器人或其它自动装置，例如本领域已知的用于放置表面安装元件的那些装置。 Mechanical placement can include, for example, a robot or other automated device, e.g., those means known in the art for placing surface mount components. 人工放置介质也在本发明范围内。 Human placement of the media is also within the scope of the present invention. 因此，可采用任何有效的机械放置方式，将具有能量源和光源的介质放置到注模部件中，使得模具部件中包含的反应性混合物的聚合反应会将能量源和光源包括到所得到的眼科镜片中。 Accordingly, any mechanical placement effective manner, having a medium energy source and a light source placed in the injection-molded part, such ophthalmic reactive polymerization reaction mixture will light energy source and the mold member comprises contained to the resulting lens.
在一些实施例中，可在将能量源和光源设置于模具部件上之前，将粘合层涂覆到模具部件上。 In some embodiments, the energy source prior to the light source and disposed on the mold member, the adhesive layer is applied to the mold part. 粘合层可包含(作为非限制性实例)颜料或单体。 The adhesive layer may comprise a (non-limiting example) a pigment or a monomer. 粘合层可通过例如喷射方法或移印方法施加。 The adhesive layer may be applied by a spraying method or pad printing method, for example. 在一些实施例中，处理器装置、MEMS、NEMS或其它元件也可置于粘合剂上并与能量源电接触。 In some embodiments, a processor device, MEMS, NEMS or other component may be placed on the adhesive and electrical contact with the energy source.
在步骤404，第一模具部件可被布置为邻近第二模具部件，以形成镜片形成腔体，至少一些反应性单体混合物、能量源和光源位于所述腔体中。 At step 404, the first mold part may be disposed adjacent to the second mold part to form a lens forming cavity, at least some of the reactive monomer mixture, an energy source and a light source located in the cavity. 在步骤405，可让腔体内的反应性单体混合物发生聚合反应。 In step 405, the cavity may be so reactive monomer mixture to polymerization reaction. 可通过例如将混合物暴露于光化辐射和热中的一者或二者来实现聚合反应。 May be achieved, for example, the polymerization reaction mixture is exposed to actinic radiation and heat one or both. 在步骤406，将镜片从模具部件中取出。 The lenses were removed from the mold part in a step 406.
在一些实施例中，粘合层可包含能与镜片材料形成互穿聚合物网络的粘合聚合物，这样就不需要在粘合剂和镜片材料间形成共价键来形成稳定的镜片。 In some embodiments, the adhesive layer may comprise an adhesive polymer capable of forming an interpenetrating polymer network with a lens material, thereby eliminating the need to form a stable lens forming covalent bonds between the binder and lens material. 对于在粘合剂中置有能量源和光源的镜片，其稳定性通过将能量源和光源夹持在粘合聚合物和镜片基体聚合物中而达成。 Opposed to the lens in a binder and a light source of an energy source, which energy source and by the stability of the light source holder in the binding polymer and the lens base polymer be reached. 本发明的粘合聚合物可包括例如由均聚物、共聚物或它们的组合(具有彼此相同的溶解度参数)制得的那些粘合聚合物，并且粘合聚合物具有与镜片材料相似的溶解度参数。 The adhesive polymers of the present invention may comprise, for example, a homopolymer, copolymer, or combination thereof (having similar solubility parameters to each other) as those obtained polymer binder, and the binding polymer has similar solubility lens material parameter. 粘合聚合物可含有可使粘合聚合物中的各聚合物和各共聚物能相互作用的官能团。 Binder polymers may contain functional groups that render the respective polymers and copolymers of the binding polymer capable of interactions with. 官能团可包括以如下方式与另外一种聚合物或共聚物的基团相互作用的一种聚合物或共聚物的基团：增加相互作用的密度以帮助抑制颜料颗粒的移动性和/或截留颜料颗粒。 Functional groups may include a manner of interacting with another group of polymers or copolymers of a group of one polymer or copolymer: increase the density of the interactions helping to inhibit the mobility and / or pigments in the pigment particles entrapped particles. 官能团间的相互作用可以是极性的、分散的、或具有电荷转移复合物性质。 Interaction between functional groups may be polar, dispersive, or with a charge transfer complex nature. 官能团可位于聚合物或共聚物主链上，或从主链悬垂。 Functional groups may be located on the polymer or copolymer backbone or pendant from the backbones.
作为非限制性例子，可将能形成具有正电荷的聚合物的单体或单体混合物与能形成具有负电荷的聚合物的一种或多种单体结合使用，以形成粘合聚合物。 As a non-limiting example, it may be capable of forming a polymer having a positive charge of monomer or monomer mixture in combination with one or more monomers capable of forming a polymer having a negative charge to form the binding polymer. 作为更具体的例子，甲基丙烯酸(“MAA”)和曱基丙烯酸酯-2-羟乙酯(“HEMA”)可用于提供MAA/HEMA共聚物，然后该共聚物与HEMA/3-(N，N-二甲基)丙基丙烯酰胺共聚物混合以形成粘合聚合物。 As a more specific example, methacrylic acid ( "MAA") and 2-hydroxyethyl acrylate Yue-yl methacrylate ( "HEMA") may be used to provide a MAA / HEMA copolymer, then the copolymer with HEMA / 3- (N , N- dimethyl) propyl acrylamide copolymer to form the binding polymer.
又如，粘合聚合物可由疏水改性单体组成，所述单体包括但不限于下式所示的酰胺和酯： As another example, the binding polymer may be composed of hydrophobically modified monomers, the monomers include, but are not limited to amides and esters represented by the following formula:
CH 3 (CH 2 ) x -L-COCHR＝CH 2 CH 3 (CH 2) x -L -COCHR = CH 2
其中L可为-NH或氧，x可为2至24的整数，R可为C 1至C 6烷基或氢，优选地为甲基或氢。 Wherein L may be -NH or oxygen, x may be an integer from 2 to 24, R may be a C 1 to C 6 alkyl or hydrogen, preferably methyl or hydrogen. 这种酰胺和酯的例子包括(但不限于)月桂基甲基丙烯酰胺和甲基丙烯酸己酯。 Examples of such amides and esters include (but are not limited to) lauryl methacrylamide, and hexyl methacrylate. 作为另一个例子，脂肪链延伸的氨基甲酸酯和脲的聚合物可用来形成粘合聚合物。 As another example, the aliphatic urethane and urea chain extending polymers used to form the binding polymer.
适合粘合层111的粘合聚合物也可包含HEMA、MAA和甲基丙烯酸月桂酯(“LMA”)的无规嵌段共聚物，HEMA和MAA或HEMA和LMA的无规嵌段共聚物，或HEMA的均聚物。 Suitable adhesive binding polymer layer 111 may also include HEMA, MAA and lauryl methacrylic acid ester random block copolymer ( "LMA") of HEMA and MAA or HEMA and LMA in a random block copolymer, or a homopolymer of HEMA. 基于粘合聚合物的总重量，这些实施例中的每种成分的重量百分比为约93至约100重量％的HEMA、约0至约2重量％的MAA和约0至约5重量％的LMA。 Based on total weight of the binding polymer, by weight of each of these components in the embodiments from about 93 percentage to about 100% by weight of HEMA, about 0 to about 2 weight percent MAA, and about 0 to about 5 weight percent LMA.
粘合聚合物的分子量可以使得其在镜片材料中稍微溶解并在镜片材料中溶胀。 The molecular weight of the binding polymer may be such that it is slightly dissolved in the lens material and swells in the lens material. 镜片材料扩散至粘合聚合物中，并发生聚合和/或交联。 Lens material diffuses into the binding polymer and is polymerized and / or crosslinked. 然而，同时，粘合聚合物的分子量不能高到影响印刷图像的质量。 However, at the same time, the molecular weight of the binding polymer can not be so high as to affect the quality of the printed image. 优选地，粘合聚合物的分子量为约7,000至约100,000M 峰 ，更优选地约7,000至约40,000M 峰 ，最优选地约17,000至约35,000M峰，其中M 峰对应于SEC分析中最高峰的分子量(＝(M n ×M w ) 1/2 ) Preferably, the molecular weight of the binding polymer is about 7,000 to about 100,000M s, more preferably from about 7,000 to about 40,000M s, most preferably from about 17,000 to about 35,000M peaks, where M corresponds to the peak of the highest peak in SEC analysis the molecular weight (= (M n × M w ) 1/2)
出于本发明的目的，可使用具有90°光散射和折射率检测器的凝胶渗透色谱仪测定分子量。 For purposes of the present invention, having a gel permeation chromatograph 90 ° light scattering detector and a refractive index of molecular weight was measured. 还使用PW4000和PW2500两根色谱柱、调节为含50mM氯化钠的甲醇-水洗脱液(重量比为75/25)以及具有在325,000至194范围内的确定分子量的聚乙二醇和聚环氧乙烷分子的混合物。 Of PW4000 and PW2500 two columns, was adjusted to 50mM sodium chloride containing methanol - water eluent (75/25 weight ratio) having a molecular weight in the range is determined to 325,000 and polyethylene glycol 194 polycyclic the mixture of ethylene oxide molecules.
本领域的普通技术人员会认识到，通过在制备粘合聚合物时使用链转移剂、通过使用大量的引发剂、通过使用活性聚合、通过选择适当的单体和引发剂浓度、通过选择溶剂的量和种类或以上方案的组合，可获得期望的粘合聚合物分子量。 Those of ordinary skill in the art will recognize that, by using an adhesive in the preparation of polymeric chain transfer agent, by using large amounts of initiator, by using living polymerization, by selection of appropriate monomer and initiator concentrations, by selection of the solvent or a combination of the amount and kind of the above scheme, the desired binding polymer molecular weight. 优选地，将链转移剂与引发剂结合使用，或更优选地，将链转移剂与引发剂和一种或多种溶剂结合使用，以获得期望的分子量。 Preferably, the chain transfer agent is used in combination with an initiator, or more preferably, the chain transfer agent and initiator agent and one or more solvents in combination to obtain the desired molecular weight. 作为另外一种选择，还可将少量的极高分子量粘合聚合物与大量的溶剂结合使用，以给粘合聚合物维持期望粘度。 Alternatively, small amounts of very high molecular weight may also be an adhesive polymer used in combination with large amounts of solvent to maintain a desired viscosity for the binding polymer. 优选地，粘合聚合物的粘度在23℃时能够为约4,000至约15,000厘泊。 Preferably the viscosity of the adhesive at 23 ℃ polymer can be about 4,000 to about 15,000 centipoise.
可用于形成本发明所用的粘合聚合物的链转移剂其链转移常数值大于约0.01，优选地大于约7，更优选地大于约25,000。 Chain transfer agents which may be used to form a chain transfer adhesive polymer used in the present invention, a constant value greater than about 0.01, preferably greater than about 7, more preferably greater than about 25,000.
可使用任何合乎需要的引发剂，包括但不限于紫外引发剂、可见光引发剂、热引发剂等以及它们的组合。 Using any desirable initiators, including, but not limited to, UV initiators, visible light initiators, thermal initiators and the like and combinations thereof. 优选使用热引发剂，更优选地，使用2，2-偶氮双异丁腈和2，2-偶氮双-2-甲基丁腈。 Preferably, a thermal initiator, more preferably 2,2-azobisisobutyronitrile and 2,2-azobis-2-methyl butyronitrile. 基于配方的总重量，所用引发剂的量为约0.1至约5重量％。 Based on the total weight of the formulation, the amount of initiator is from about 0.1 to about 5% by weight. 优选地，将2，2-偶氮双-2-甲基丁腈与十二硫醇一起使用。 Preferably, for use with 2,2-azobis-2-methylbutyronitrile and dodecanethiol.
粘合聚合物层或其它介质111可通过任何便利的聚合方法制成，这些方法包括但不限于自由基链聚合、逐步聚合、乳液聚合、离子链聚合、开环作用、基团转移聚合、原子转移聚合等。 Binding polymer layer or other media 111 may be made by any convenient polymerization method, including but not limited to, radical chain polymerization, step polymerization, emulsion polymerization, ionic chain polymerization, ring opening, group transfer polymerization, atom transfer polymerization. 优选使用热引发的自由基聚合反应。 Preferably, a thermal radical polymerization initiator. 进行聚合反应的条件属于本领域普通技术人员的知识范围。 Polymerization conditions within the knowledge of one of ordinary skill in the art.
可用于制备粘合聚合物的溶剂为中沸点溶剂，其沸点介于约120℃和230℃之间。 Solvents useful in the preparation of an adhesive polymer is the boiling point of the solvent, a boiling point between about 120 deg.] C and 230 ℃. 根据要制备的粘合聚合物的类型及其分子量来选择要使用的溶剂。 Depending on the type and molecular weight of the binding polymer to be prepared to use the solvent selected. 合适的溶剂包括但不限于双丙酮醇、环己酮、乳酸异丙酯、3-甲氧基-1-丁醇、1-乙氧基-2-丙醇等。 Suitable solvents include, without limitation, diacetone alcohol, cyclohexanone, isopropyl lactate, 3-methoxy-1-butanol, 1-ethoxy-2-propanol.
在一些实施例中，本发明的粘合聚合物层可根据在水中的膨胀系数定制成适于将要与其一起使用的镜片材料。 In some embodiments, the adhesive polymer layer of the present invention may be adapted to be customized for use with lens materials in accordance with its coefficient of expansion in water. 使粘合聚合物的膨胀系数与充填溶液中的固化镜片材料的膨胀系数匹配或大致匹配可有利于避免在镜片中产生应力，应力会导致不良的光学性能和镜片参数变化。 Expansion coefficient of the cured lens material of the adhesive polymer solution filling expansion coefficient matches or substantially matches may be advantageous to avoid stress in the lens, the stress lead to poor optical properties and lens parameters. 另外，粘合聚合物可在镜片材料中具有溶胀性，使得用本发明的着色剂印出的图像可溶胀。 Additionally, the binding polymer can swellable in the lens material, so that the colorant of the present invention, the printed image may swell. 由于这样的溶胀，图像被截留在镜片材料中，而不会对镜片舒适度产生任何影响。 Because of this swelling, the image being entrapped within the lens material without any impact on lens comfort.
在一些实施例中，着色剂可包含在粘合层中。 In some embodiments, the colorant may be included in the adhesive layer. 在本发明的着色剂中可与粘合聚合物一起使用的颜料为那些适用于接触镜片的有机颜料或无机颜料，或这些颜料的组合。 Pigments useful with the binding polymer in the colorants of the invention are those suitable for contact lenses combination of organic or inorganic pigments, or combinations of these pigments. 可通过改变所用颜料和遮光剂的浓度控制不透明度，用量越大产生的不透明度越高。 May be controlled by varying the pigment concentration and opacifiers opacity, higher amounts yielding greater opacity. 示例性的有机颜料包括但不限于酞菁蓝、酞菁绿、咔唑紫、还原橙#1等，以及它们的组合。 Exemplary organic pigments include, but are not limited to, phthalocyanine blue, phthalocyanine green, carbazole violet, vat orange # 1, etc., and combinations thereof. 可用的无机颜料的例子包括但不限于氧化铁黑、氧化铁棕、氧化铁黄、氧化铁红、二氧化钛等，以及它们的组合。 Examples of useful inorganic pigments include, but are not limited to, iron oxide black, iron oxide brown, iron oxide yellow, iron oxide red, titanium dioxide, etc., and combinations thereof. 除了这些颜料外，可使用可溶和不可溶染料，所述染料包括但不限于二氯三嗪和乙烯砜型染料。 In addition to these pigments, soluble and insoluble may be used a dye including, without limitation, dichlorotriazine and vinyl sulfone dye. 可用的染料和颜料均市售可得。 Available dyes and pigments are commercially available.
用粘合聚合物涂覆或润湿颜料颗粒可使得颜料颗粒在本体粘合聚合物中具有更好的分散性。 Polymer coated with an adhesive or wetting of the pigment particles such that the pigment particles can have a better dispersion in the bulk binding polymer. 涂覆可通过使用静电力、分散力或氢键力来实现以覆盖颜料的表面。 Coating the surface coverage may be achieved by using an electrostatic force pigments, dispersion forces, or hydrogen bonding. 优选地，使用高剪切力将颜料分散到粘合聚合物中。 Preferably, high shear to disperse the pigment into the binding polymer. 可通过如下方法将颜料添加到粘合聚合物中：将聚合物和颜料分配到合适的搅拌器(如转轴搅拌器)中并混合，直到生成均一的混合物，通常最多约30分钟的时间。 By the following method may be added to the adhesive polymer pigment: assigning polymer and pigment into a suitable blender (e.g., stirrer shaft) and mixed until a homogeneous mixture, generally up to about 30 minutes. 然后可将混合物送至高剪切研磨机(如Eiger研磨机)中，以将颜料分散到粘合聚合物中。 The mixture may then be fed to a high shear mill (e.g. Eiger mill) to disperse the pigment into the binding polymer. 根据需要重复进行研磨，以达到完全分散。 Polishing repeated as necessary to achieve complete dispersion. 通常，进行研磨直到颜料大小为约0.2至约3微米。 Usually, the pigment is ground until a size of from about 0.2 to about 3 microns. 研磨可使用任何合适的市售装置进行，市售装置包括但不限于高剪切研磨装置或球磨装置。 Grinding using any suitable commercially available device, commercially available devices including but not limited to high shear or ball milling device means.
除了颜料和粘合聚合物之外，在一些实施例中，粘合层还包含一种或多种有助于将粘合层涂覆到模具部件上的溶剂。 In addition to the pigment and binding polymer, in some embodiments, the adhesive layer further comprises one or more adhesive layer applied to aid in the solvent onto the mold part. 本发明的另一发现是，为了有利于在其所施加到的模具部件表面上不渗出或滑动的粘合层，期望的是，并且优选地，粘合层的表面张力低于约27mN/m。 Another finding of the present invention, in order to facilitate the mold part surface to which it is applied does not bleed or sliding the adhesive layer, it is desirable, and preferably, the adhesive layer is lower than the surface tension of about 27mN / m. 这种表面张力可通过对将要施加粘合层111的表面(例如模具表面)进行处理而实现。 This surface tension may be applied to a surface (e.g. mold surface) of the adhesive layer 111 is achieved by treatment. 可使用本领域已知的技术进行表面处理，这些技术例如但不限于等离子体处理和电晕处理。 Using techniques known in the art surface treatment techniques such as, but not limited to plasma and corona treatment. 作为另外一种选择，并且优选地，期望的表面张力可通过选择用于着色剂的溶剂来实现。 Alternatively, and preferably, the desired surface tension may be achieved by selecting the solvent for the colorant.
因此，可用于粘合层的示例性溶剂包括那些能够增加或降低粘合层粘度并帮助控制表面张力的溶剂。 Accordingly, exemplary solvents that may be used for the adhesive layer include those pressure-sensitive adhesive layer can be increased or decreased viscosity and surface tension to help control solvent. 合适的溶剂包括但不限于环戊酮、4-甲基-2-戊酮、1-甲氧基-2-丙醇、1-乙氧基-2-丙醇、乳酸异丙酯等以及它们的组合。 Suitable solvents include, but are not limited to cyclopentanone, 4-methyl-2-pentanone, 1-methoxy-2-propanol, 1-ethoxy-2-propanol, isopropyl lactate and the like and The combination. 优选使用1-乙氧基-2-丙醇和乳酸异丙酯。 Preferably, 1-ethoxy-2-propanol and isopropyl lactate.
在一些优选的实施例中，本发明的粘合层材料中使用至少三种不同的溶剂。 In some preferred embodiments, the adhesive layer material used in the present invention, at least three different solvents. 这些溶剂的前两种均为中沸点溶剂，用于制备粘合聚合物。 The first two are the boiling point of the solvent thereof, for preparing an adhesive polymer. 尽管在粘合聚合物形成后可将这些溶剂从粘合聚合物除去，但优选保留它们。 Although these solvents may be removed from the adhesive polymer is a polymer formed after bonding, but preferably retain them. 优选地，这两种溶剂为1-乙氧基-2-丙醇和乳酸异丙酯。 Preferably, the two solvents are 1-ethoxy-2-propanol and isopropyl lactate. 另外一种为低沸点溶剂，即其沸点介于约75℃和约120℃之间的溶剂，可用于根据需要降低着色剂的粘度。 Another is the low-boiling solvent, i.e. a solvent having a boiling point range of between about 75 deg.] C and about 120 deg.] C, can be used to reduce the viscosity of the colorant as desired. 合适的低沸点溶剂包括但不限于2-丙醇、1-甲氧基-2-丙醇、1-丙醇等以及它们的组合。 Suitable low boiling solvents include, but are not limited to, 2-propanol, 1-methoxy-2-propanol, 1-propanol and the like, and combinations thereof. 优选使用1-丙醇。 Preferably, 1-propanol.
所用溶剂的具体数量可取决于很多因素。 On the specific amount of the solvent may depend on many factors. 例如，用于形成粘合聚合物的溶剂量可能取决于期望的粘合聚合物分子量，以及粘合聚合物中所用的各种成分，例如单体和共聚物。 For example, the amount of solvent used to form the binding polymer may depend on the desired molecular weight of the polymer binder, and an adhesive polymer used in the various components, such as monomers and copolymers. 所用低沸点溶剂的量将取决于着色剂期望的粘度和表面张力。 The amount of low boiling solvent used will depend upon the desired colorant viscosity and surface tension. 此外，如果着色剂要施加于模具并与镜片材料一起固化，所用溶剂的量将取决于所用的镜片和模具材料，以及模具材料是否已经过任何表面处理以增加其可湿性。 Further, if the colorant is to be applied to a mold and cured with a lens material together with the amount of solvent used will depend upon the lens and mold materials used and whether the mold material has been any surface treatment to increase its wettability. 要使用的溶剂精确量的确定在本领域普通技术人员技能范围内。 The precise amount of solvent to be used is determined within the skill of those of ordinary skill in the art. 通常，所用溶剂的总重量将占待使用溶剂的约40至约75重量％。 Typically, the solvent will account for the total weight of the solvent to be used is from about 40 to about 75 wt%.
除了溶剂之外，可以且优选地将增塑剂加到粘合层以减少在干燥粘合层时的开裂，并增强镜片材料对粘合层的扩散和溶胀。 In addition to the solvent, and preferably the plasticizer is added to the adhesive layer to reduce cracking during the drying of the adhesive layer, and to enhance adhesion of the lens material and diffusion layer swelling. 所用增塑剂的种类和量将取决于所用粘合聚合物的分子量，并且，对于放置到先储存再使用的模具上的着色剂，则取决于期望的架藏稳定性。 The type and amount of plasticizer used will depend upon the molecular weight of the shelf stability of the binder polymer used and, for colorants placed onto the mold and then stored prior to use, it depends on the desired. 可用的增塑剂包括但不限于甘油、丙二醇、二丙二醇、三丙二醇、聚乙二醇200、400或600等以及它们的组合。 Useful plasticizers include but are not limited to glycerol, propylene glycol, dipropylene glycol, tripropylene glycol, polyethylene glycol 200, 400 or 600, and combinations thereof. 优选使用甘油。 Preferably glycerol. 基于着色剂的重量，所用增塑剂的量通常将为0至约10重量％。 Based on the weight of the colorant, the amount of plasticizer used generally will be 0 to about 10 wt%.
本领域的普通技术人员会认识到，本发明的粘合层组合物中还可包括上述添加剂之外的添加剂。 Those of ordinary skill in the art will recognize that the adhesive layer composition of the present invention may further include additives other than the aforementioned additives. 合适的添加剂包括(但不限于)用于有助于流动性和流平性的添加剂、用于防止起泡的添加剂、用于流变学改性的添加剂等，以及它们的组合。 Suitable additives include (but are not limited to), additives that aid flow and leveling properties, additives for foam prevention, additives for rheology modification, and the like, and combinations thereof.
在本发明的一些实施例中，在镜片材料固化后，粘合层嵌入镜片材料中。 In some embodiments of the present invention, after the lens material is cured, the adhesive layer is embedded in the lens material. 这样，粘合层可以更靠近所形成的镜片的前表面或后表面嵌入，这取决于镜片中粘合层所施加到的模具表面。 Thus, the adhesive layer may embed closer to the front surface of the lens formed on the surface or after, depending on the lens mold surface to which the adhesive layer is applied. 另外，可以任何顺序施加一层或多层的粘合层。 Further, in any order one or more layers applied to the adhesive layer.
尽管本发明可用于提供由任何已知的镜片材料或适合制作刚性或软质接触镜片的材料制得的刚性或软质接触镜片，但是优选地，本发明的镜片为水含量为约0至约90％的软质接触镜片。 While the present invention may be used by any known lens material, or suitable for making rigid or soft contact lenses made of a material rigid or soft contact lenses, but preferably, the lenses of the invention is a water content of from about 0 to about 90% of soft contact lenses. 更优选地，镜片由含有羟基、羧基或两者的单体制成，或者由含有机硅的聚合物(例如硅氧烷、水凝胶、硅水凝胶以及它们的组合)制成。 More preferably, the lenses are made of monomers containing a hydroxyl group, a carboxyl group, or both, or made of a silicone-containing polymer (e.g. silicone, hydrogels, silicone hydrogels, and combinations thereof). 可用于形成本发明镜片的材料可通过使大分子单体、单体以及它们的组合的共混物与添加剂(例如聚合引发剂)反应制得。 Materials useful for forming the lenses of the invention by reacting a macromer, monomers, and combinations thereof blends with additives (e.g. a polymerization initiator) prepared by the reaction. 合适的材料包括(但不限于)由有机硅大分子单体和亲水单体制成的有机硅水凝胶。 Suitable materials include (but are not limited to) silicone hydrogels made from silicone macromers and hydrophilic monomers.
现在参见图5，在本发明的另一方面，将安装在介质上的能量源和光源设置在模具腔体内以形成眼科镜片。 Referring now to FIG. 5, in another aspect of the present invention, mounted on the media source and an energy source disposed in a mold cavity to form the ophthalmic lens. 在步骤501，如上所述将能量源和光源设置在眼科镜片模具部件内。 In step 501, the energy source as described above and a light source disposed within an ophthalmic lens mold part.
在步骤502，将能量源设置为与光源或其它被另外安装在介质上并被设置在模具部件内的元件电连通。 At step 502, the energy source is placed in fluid communication with the light source or other electrical components are mounted on the medium and further disposed in the mold member. 电连通可通过例如装配在插入物内的电路或通过以喷射方式或其它方式直接在镜片材料上形成的通路来实现。 For example, electrical communication can be fitted by a circuit within the implant is inserted in a passage or by injection, or otherwise formed directly on the lens material.
在步骤503，使设置在腔体内的反应性混合物发生聚合反应以形成镜片。 In step 503, it provided that the reaction mixture within the cavity is polymerized to form a lens. 可通过例如将反应性混合物暴露于光化辐射来实现聚合反应。 Polymerization reaction may be achieved, for example, the reaction mixture is exposed to actinic radiation.
现在参见图3，示出自动设备310具有一个或多个介质传输接口311。 Referring now to FIG. 3, there is shown an automatic device 310 having one or more transmission media interface 311. 如图所示，托盘313上包括各自带有相关介质314的多个模具部件，这些部件被递送到介质传输接口311。 As shown, the tray 313 comprises a plurality of mold members each having associated media 314, these components are delivered to a transmission medium interface 311. 实施例中可包括分别将能量源和光源设置在多个介质314内的单个接口311，或同时将能量源和光源设置在多个介质(例如模具部件314)内的多个接口(未示出)中，并且在一些实施例中，设置在每个模具中。 Example embodiments may include an energy source and the light source are arranged in a plurality of individual interface 311 of the media 314, while the energy source or sources and a plurality of interfaces in multiple media (e.g. mold parts 314) (not shown ), and in some embodiments, provided in each mold.
一些实施例另一方面还包括支承设备，以支承包含眼科镜片能量源和光源的各个元件，与此同时眼科镜片的主体围绕这些元件模制。 Some embodiments further include a support device on the other hand, to support the various elements comprising an ophthalmic lens Energy Source and the light source, while the body of the ophthalmic lens is molded around these elements. 在一些实施例中，能量源和光源可固定到镜片模具内的固定点上(未示出)。 In some embodiments, the energy source and the light source may be fixed to a fixed point within a lens mold (not shown). 该固定点可附着将形成镜片主体的同一类型的聚合材料。 The fixed point may be attached to the same type of lens body formed of a polymeric material.
现在参见图6，其中示出了可用于本发明的一些实施例的控制器600。 Referring now to Figure 6, there is shown a controller 600 may be used in some embodiments of the present invention. 控制器600包括处理器610，其可包括耦合至通信装置620的一个或多个处理器元件。 The controller 600 includes a processor 610, which may include the communication apparatus 620 coupled to one or more processor elements. 在一些实施例中，控制器600可用于将能量发送到设置在眼科镜片内的能量源和光源。 In some embodiments, controller 600 may be used to transmit energy to an energy source and a light source disposed within the ophthalmic lens.
控制器可包括耦合至被构造成经由通信信道而进行能量通信的通信装置的一个或多个处理器。 The controller may comprise one or more processors coupled to the communication device via the communication energy communication channel is configured. 通信装置可用于对以下一者或多者进行电子控制：将能量源放置在眼科镜片内；相对于眼科镜片往返传输数字数据；或控制被装入眼科镜片内的光源或其它元件。 The communication device may be used for electronically controlling one or more of the following: an energy source placed within an ophthalmic lens; ophthalmic lens with respect to the round-trip transmission of digital data; is loaded or control or other light source within the ophthalmic lens element.
通信装置620还可用于例如与一个或多个控制器设备或制造设备元件进行通信。 For example, the communication device 620 may also communicate with one or more controller apparatus or manufacturing equipment components.
处理器610还与存储装置630连通。 The processor 610 also communicates with the storage device 630. 存储装置630可包括任何合适的信息存储装置，包括磁存储装置(例如，磁带和硬盘驱动器)、光存储装置和/或半导体存储器装置(例如，随机存取存储器(RAM)装置和只读存储器(ROM)装置)的组合。 The storage device 630 may comprise any appropriate information storage device, a magnetic storage device (e.g., magnetic tape and hard disk drives), optical storage devices, and / or a semiconductor memory device (e.g., a random access memory (RAM) and read only memory devices ( ROM) combination apparatus).
存储装置630可存储用于控制处理器610的程序640。 The storage device 630 may store a program for controlling the processor 610 640. 处理器610执行程序640的指令，从而根据本发明进行操作。 The processor 610 performs instructions of the program 640, and thereby operates in accordance with the present invention. 存储装置630还可在一个或多个数据库中存储眼科相关的数据。 Data storage device 630 may also be stored in one or more databases associated with ophthalmic. 数据库可包括定制的能量源和光源设计、计量数据和用于控制能量往返于能量源和光源的具体控制序列。 Specific control sequence database may include customized energy source and light design, measurement data and for controlling energy to and from the energy source and the light source.
在一些实施例中，具有激活元件的眼科镜片可用来从装于眼科装置内的能量源提供能量。 In some embodiments, an ophthalmic lens has an activation element may be used to provide energy from the energy source mounted in the ophthalmic device.
现在参见图7，可嵌入通电眼科镜片100中的不同类型的能量源中可包含的一些选择的视图在图7中如标号700所示。 Referring now to FIG. 7, may be embedded in some of the selected view of different types of energy source in the energized ophthalmic lens 100 that can be included in the reference numeral 700 in FIG. 7 as shown in FIG. 如前所述，能量源的一组实施例可包括电池。 A group of previously described embodiments, the energy source may include a battery. 电池在图7中如标号720所示。 Cell in FIG. 7 as reference numeral 720 in FIG. 图7还以可储存能量密度为序给出了各可选能量源的图解。 7 also shows the energy density stored in each illustrating alternative energy source for the order. 电池例如包括能量密度从约50至约800Whr/L的区域。 Energy density batteries include, for example from about 50 to about 800Whr L region /. 通常，不考虑特定能量源的其它方面，能量储存的密度越高，能量源越理想。 Generally, other aspects Regardless of the particular energy source, the higher the energy storage density, the more desirable energy source.
由该图700可知，从能量密度角度看，能量采集器(标号740)最不理想。 700 seen from the drawing, from the perspective of the energy density, the energy harvester (reference numeral 740) is not the most desirable. 然而，对于本领域技术人员而言显而易见的是，存在能量采集器会具有优势的其它方式。 However, those skilled in the art obvious that there are other ways energy harvester may have advantages.
例如，能量采集器可包括光伏电池、温差电池或压电电池。 For example, the energy harvester may include photovoltaic cells, thermoelectric cells or piezoelectric cells. 这类采集器的有益方面在于其可以从环境中吸收能量，然后可以提供电能，而无需线连接。 Advantageous aspects of such collector can absorb energy from the environment in that it then can provide electrical energy without wires. 在一些实施例中，采集器可构成通电眼科镜片中的能量源。 In some embodiments, the collectors may constitute an energy source in the energized ophthalmic lens. 然而，在其它实施例中，能量采集器可与能够以电的形式储存能量的其它能量源结合使用。 However, in other embodiments, energy harvester may be combined with other energy sources capable of storing energy in the form of electricity.
其它类型的能量源包括电容器型装置730。 Other types of energy source comprises a capacitor-type device 730. 显而易见的是，电容器构成的能量密度解决方案高于能量采集器但低于电池720。 It is apparent that the energy density of the capacitor constituting the solution but lower than the battery energy harvester 720. 尽管如此，电容器具有一些固有优势。 Nevertheless, the capacitor has some inherent advantages.
电容器是以电的形式储存能量的一种能量源，因此，它是可与能量采集器结合使用的能量源之一，从而形成能够储存能量的无线能量源。 The capacitor is an energy source in the form of electrically stored energy, therefore, it is one of the energy source may be used in conjunction with the energy harvester to form a wireless energy source capable of storing energy. 通常，电容器优于电池之处在于，其具有通常高于电池的功率密度。 Typically, the capacitor batteries is superior in that it has a power density is generally higher than the battery. 存在多种不同类型的电容器，其中包括：标准电薄膜电容器、聚酯薄膜电容器、电解电容器和技术相对较新且更先进的高密度纳米级电容器或称作超级电容器。 There are many different types of capacitors, including: standard electrical film capacitor, a polyester film capacitors, electrolytic capacitors and relative newer and more advanced technologies of high density nanoscale capacitors or supercapacitors referred.
在另一些实施例中，包括电化学电池或者说电池720在内的能量源可确定较为理想的工作点。 In other embodiments, an electrochemical cell or battery including an energy source 720 may determine the ideal operating point. 电池具有多种有利特性。 Battery has various advantageous characteristics. 例如，电池以直接转化为电能的形式储存能量。 For example, a battery to store energy in the form of directly into electrical energy. 一些电池可为可再充电或可再加电，因此其代表能够连接到能量采集器的另一类能量源。 Some batteries may be rechargeable, or may be electrically coupled, thus representing an energy harvester can be connected to another type of energy source. 由于电池具有相对高的能量密度，因此，电池储存的能量可执行一些具有适当能量要求的功能。 As the battery has a relatively high energy density, the energy stored in the battery may perform some functions having appropriate energy requirements. 此外，电池可以装配成柔性形式。 In addition, the battery can be assembled into a flexible form. 对于要求高功率容量的应用而言，对于本领域技术人员显而易见的是，还可将电池连接到电容器。 For applications requiring high power capability, the skilled person will be apparent that also connect the battery to the capacitor. 可存在使电池成为通电眼科镜片中的能量源的至少一部分的许多实施例。 There may be many embodiments of the battery becomes at least a portion of the energy source in the energized ophthalmic lens.
另一种实施例可包括用作能量源710的燃料电池。 Another embodiment may include a fuel cell as an energy source 710. 燃料电池通过消耗化学燃料源产生电能，消耗化学燃料源后会产生电能和副产物(包括热能)。 Fuel cell generates electricity by consuming a chemical fuel source, the fuel consumption of the chemical source of electrical energy and produces byproducts (including thermal). 用生物可供材料作为燃料源的燃料电池实施例或许是可能的。 Biological material for use as a fuel source, the fuel cell embodiments may be possible. 然而一般来讲，除了能量源提供的有利能量密度之外，能量源可能还受到技术复杂性的影响，且通常可能不具备眼科应用所要求的必要的小规模。 Generally, however, in addition to the advantageous energy source provides energy density, the energy source may also be affected by the technical complexity and generally may not have the necessary small scale required for ophthalmic applications. 此外，如果不能从眼环境中以某种方式提取燃料源，则与可再加电的能量源相比，其可能会受实际能量密度的影响。 Additionally, if not in some way to extract from a fuel source in the ocular environment, compared with the energy source may be electrically coupled, which may be affected by the actual energy density.
以下对本发明实施例的讨论可能在总体上以用电池作为通电眼科镜片的主要能量源为重点。 The following discussion of the embodiments of the present invention are possible in general to use a battery as a main power source energized ophthalmic lens focusing. 这种重点讨论不应限制本发明的范围，因为有许多能量源(包括前述的那些能量源)可以构成通电眼科镜片的实施例。 This focus on the scope of the invention should not be limited, because there are many sources of energy (including those of the energy source) may be configured in embodiments of an energized ophthalmic lens.
如在本发明一些实施例中所提及，能量源包括电化学电池或者说电池。 As mentioned, in some embodiments of the present invention and the energy source comprises an electrochemical cell or battery. 存在多种可包括在通电眼科镜片实施例中的不同类型的电池。 There are various embodiments may include different types of batteries in an energized ophthalmic lens embodiment. 例如，单次使用电池可由各种阴极和阳极材料形成。 For example, single use batteries may be formed of various cathode and anode materials. 这些材料可以非限制性例子的方式包括锌、碳、银、锰、钴、锂和硅。 These materials may be non-limiting manner examples include zinc, carbon, silver, manganese, cobalt, lithium and silicon. 其它实施例源自可再充电电池的应用。 Other embodiments may be applied from the rechargeable battery. 这类电池可继而由以下一种或多种材料制成：锂离子技术、银技术、镁技术、铌技术或其它提供电流的材料。 Such cells may then be made of one or more of the following materials: lithium-ion technology, silver technology, Magnesium technology, Niobium technology or other materials to supply current. 对于本领域技术人员而言显而易见的是，单次使用或可再充电的电池系统的多种当前电池技术可包括通电眼科镜片各种实施例中的能量源。 Those skilled in the art will be apparent that a battery system using a single or a plurality of rechargeable battery technologies currently energized ophthalmic lens may include a variety of energy sources in the embodiment.
与其它类型相比，接触镜片环境的物理和尺寸约束可有利于某些电池类型。 Compared with other types of contact lens environment and physical size constraints may favor certain battery types. 这种有利性的例子可出现于薄膜电池。 Examples of such advantageous properties appear in thin film batteries. 薄膜电池可占据符合人眼科实施例的很小的空间体积。 Thin film batteries may occupy the small space consistent with human ophthalmic embodiments the volume. 此外，薄膜电池可在柔性基底上形成，这允许眼科镜片和内置电池两者的主体随基底自由挠曲。 Further, the thin film battery may be formed on a flexible substrate, which allows the body to both the ophthalmic lens and the substrate with the built-in battery free to deflect.
对于薄膜电池而言，例子可包括单次充电和可再充电形式。 For thin film batteries, examples may include single charge and rechargeable forms. 可再充电电池具有延长可用产品寿命的能力，因此，能够维持更高的能量消耗率。 The rechargeable battery having the ability to extend the usable life of the product, it is possible to maintain a higher energy consumption rates. 虽然大量的研发活动均集中在生产具有可再充电薄膜电池的电通电眼科镜片技术上，然而，本发明技术并不局限于该子类。 Although a lot of research and development activities are concentrated on the production of electrically energized ophthalmic lenses with rechargeable thin film technology battery, however, the techniques of this invention is not limited to this subclass.
可再充电薄膜电池可商购自例如橡树岭国家实验室(Oak Ridge NationalLaboratory)，其于二十世纪九十年代初起已生产出多种可再充电薄膜电池形式。 Rechargeable thin film batteries are commercially available from, for example, Oak Ridge National Laboratory (Oak Ridge NationalLaboratory), which has produced a variety of rechargeable batteries in the form of a thin film to the beginning of the 1990s. 这类电池的当前商业生产厂家包括Excellatron Solid State，LLC(Atlanta，GA)、Infinite Power Solutions(Littleton，CO)和Cymbet Corporation(Elk River，MN)。 Such cell current commercial manufacturers including Excellatron Solid State, LLC (Atlanta, GA), Infinite Power Solutions (Littleton, CO) and Cymbet Corporation (Elk River, MN). 该技术当前占据支配地位的是包括平薄膜电池在内的应用。 The currently dominant technology is a flat film comprising a battery, including application. 此类电池的应用可构成本发明技术的一些实施例；然而，使薄膜电池形成三维形状(例如具有球形曲率半径)构成本发明技术的期望实施例。 Some embodiments of the application of such techniques may constitute a battery of the present invention; however, the thin film battery form a three-dimensional shape (e.g., a spherical radius of curvature) of the desired constituting the techniques of this embodiment of the invention. 对于本领域技术人员而言显而易见的是，这种三维电池实施例的多种形状和形式在本发明的范围之内。 Those skilled in the art will be apparent that a variety of shapes and forms of embodiment of such three-dimensional battery within the scope of the present invention.
图8a、8b、8c和8d中示出了眼科镜片中的能量源可采用的不同形状的许多实例。 FIG. 8a, 8b, 8c and 8d illustrate a number of examples in the energy source may be employed in the ophthalmic lens different shapes. 标号800示出的是由薄膜材料制成的基准能量源，其形成为平坦形状以用作基准。 Reference numeral 800 shows a reference Energy Source made of thin film material, which is formed in a flat shape as a reference. 当这种形状800的尺寸大略为毫米量级时，其可以构成用于通电眼科镜片的能量源810示出的是示例性的三维形式，其中柔性基底和封装电池呈完全环状，当其未发生柔性变形时，其与未变形眼科镜片可呈现的形状大致相同。 When such a shape roughly the size of 800 millimeters, an energy source 810 which may be configured for an energized ophthalmic lens is shown an exemplary three dimensional form where the flexible substrate and encapsulated battery was completely annular when it is not the flexible deformation, which is substantially the same as the undeformed shape of ophthalmic lens may be presented. 在一些实施例中，对于通电眼科镜片实施例，环形的半径可约为8毫米。 In some embodiments, for an energized ophthalmic lens embodiment, the annular radius may be about 8 mm. 四分之一环面830或半环面820的实施例，都可以采用相同的三维方位。 Example 830 a quarter torus or annulus half 820, can use the same three-dimensional orientation. 对于本领域技术人员而言显而易见的是，包括其它部分环状形状在内的多种不同形状可构成本发明范围内的替代实施例。 Those skilled in the art obvious that other portions comprises an annular shape, including a variety of different shapes can be configured within the scope of alternative embodiments of the present invention.
本发明的另一组实施例涉及可有利地用于通电眼科镜片中的特定的电池化学物质的组成与性质。 Another embodiment of the present invention relates to a group can be advantageously used in the composition and properties of a particular energized ophthalmic lens of battery chemistry. 由橡树岭国家实验室(Oak Ridge Laboratories)开发的示例性实施例包括锂或锂离子电池的组分。 By the Oak Ridge National Laboratory (Oak Ridge Laboratories) developed an exemplary embodiment includes the components of the lithium or lithium-ion batteries. 用于这种电池的阳极的通用材料包括锂金属，或者可供选择地，用于锂离子电池的通用材料可包括石墨。 Materials for the anode of such cells include a lithium metal, or alternatively, for a lithium ion battery may comprise a general-purpose material graphite. 这些电池的示例性替代实施例可为，采用微米级的硅特征充当装配在接触镜片中的此类薄膜电池的阳极。 Exemplary alternative embodiments of these embodiments may be a battery, characterized silicon using micron-sized battery serves as an anode assembly such films in the contact lens.
用于该新技术的电池阴极所用的材料也可包括多种材料选择。 Cell cathode for the new technique the materials used may also comprise more materials selected. 通用的阴极材料包括锂锰氧化物和锂钴氧化物，这些材料使得如此形成的电池具有良好的性能指标。 Common cathode material comprises lithium manganese oxide and lithium cobalt oxide, these materials are formed such that the battery thus has a good performance. 作为另外一种选择，磷酸铁锂阴极可具有相似的性能，然而，其可能在某些应用中具有与充电相关的改善方面。 Alternatively, the lithium iron phosphate cathode may have similar performance, however, it may be relevant to the improvement of charge in some applications. 并且，这些阴极材料和其它阴极材料的尺寸可以改善充电性能；例如，通过用各种材料的纳米级晶体形成阴极，可以显著改善电池可被再充电的速率。 Further, the size of the cathode material and the other of these cathode materials can improve charging performance; e.g., by forming the cathode using nanocrystals of various materials, can significantly improve the battery can be recharged rate.
一些实施例可以包括用将能量源和光源与其所处环境隔离的材料封装能量源和光源。 Some embodiments may include a material encapsulating the light source and the energy source and the energy source and its environment isolated. 理想的方式可以是封装能量源和光源，以大体隔离其组分使之不会进入眼环境。 Ideal way may be a package and light source energy, to isolate its constituents to make it generally does not enter the ocular environment. 或者，如果没有通过封装实施例适当隔离能量源和光源，则眼环境的各个方面会对能量源和光源的性能产生负面影响。 Alternatively, if the embodiment proper isolation and energy source by the light source is not implemented the package, the various aspects of the performance and energy source have ocular environment of a light source have a negative impact. 本发明技术的多个实施例可源自材料的选择。 Selecting a plurality of embodiments may be derived from technical material of the present invention.
参见图9，标号900所示出的是通电眼科镜片的示例性实施例的视图。 Referring to Figure 9, reference numeral 900 shown is a view of an exemplary embodiment of an energized ophthalmic lens. 在该图示中，能量源910可包括薄膜、可再充电锂离子电池。 In this illustration, the energy source 910 may include a thin film, rechargeable lithium ion battery. 电池可具有触点970以便于互连。 Battery 970 may have contacts for the interconnect. 引线可以是连接到触点970的引线接合线，并将电池连接到可用于给电池能量源910再加电的光伏电池960。 May be connected to the lead wire bonding line contact 970, and the battery is connected to the battery power source 910 may be used to electrically coupled photovoltaic cell 960. 另外的引线可以通过第二组触点950上的接有引线的接触件将能量源连接到柔性电路互连线。 Additional leads may be connected by a second set of contacts on the contact member 950 is connected to an energy source leads to the flex circuit interconnect. 这些触点950可以为还可包含光源930的柔性互连基底955的一部分。 These contacts a portion of the flexible interconnect substrate 950 may further include a light source 930 955. 该互连基底可通过与前述能量源类似的方式成形为近似于典型镜片形式的形状。 The interconnect substrate can be formed into a shape approximating a typical lens form by the energy source in a similar manner. 然而，为了增加额外的柔韧性，互连基底955可以包括沿其长度布置的附加形状特征，例如径向切口945。 However, to add additional flexibility, an interconnect substrate 955 may include additional shape features disposed along its length, for example, radial cuts 945. 互连基底955的单个瓣片可以被连接各种如IC那样的电子元件、分立元件、无源元件以及如标号990示出的装置。 Interconnect substrate 955 is a single flap may be connected various electronic components such as the IC, element, such as a passive element, and reference numeral 990 means a discrete shown. 这些元件通过引线或其它连接装置940互连到互连基底955内的导通路径。 These elements are connected by wire or other interconnect means 940 to the conduction paths within the interconnect substrate 955. 作为非限制性例子，各种元件可以通过可与前述的电池形成互连的各种装置连接到柔性互连基底955。 As non-limiting examples of various devices, various elements may be formed by the interconnection of the battery 955 is connected to the flexible interconnect substrate. 各种电元件的组合可以确定标号990所示的电光装置的控制信号。 Combination of the various electrical elements to determine the control signal may be an electro-optical device shown in reference numeral 990. 该控制信号可以沿着互连线920传导。 The control signal may be conducted along interconnect line 920. 具有通电功能的该类型示例性通电眼科镜片仅出于示例性目的提供。 This type of exemplary energized ophthalmic lens with energized function is provided only for exemplary purposes. 不应将此描述解释为限制本发明技术的范围，因为对于本领域技术人员而言显而易见的是，可存在功能、设计、互连方案、通电方案以及本发明概念的总体利用的多个不同实施例。 This description should not be construed as limiting the technical scope of the invention, as those skilled in the art will be apparent that there may function, design, interconnection scheme, energization scheme and overall utilization of a plurality of different embodiments of the inventive concept example.
在一些实施例中，可存在影响眼科镜片外观的方式。 In some embodiments, the present embodiment may affect the appearance of the ophthalmic lens. 可通过各种方式改变薄膜微电池表面的美感，其在嵌入电活性接触镜片或成型水凝胶制品后会呈现特定的外观。 Microbattery surface may be varied aesthetics of the film in various ways, which will show the particular appearance after embedding the electroactive contact lens or shaped hydrogel article. 在一些实施例中，薄膜微电池可采用美观的图案化和/或彩色包装材料制造，这种美观的图案化和/或彩色包装材料可以为薄膜微电池提供柔和的外观，或者作为另外一种选择，可以提供虹膜样彩色图案、纯色和/或混色图案、反光花纹、彩虹色花纹、金属色花纹或可能的任何其它艺术设计或图案。 In some embodiments, the thin film microbattery may be employed aesthetic pattern and / or colored packaging materials for producing such aesthetic pattern and / or colored packaging materials may provide a soft appearance as a thin film microbattery or alternatively selection may be provided iris-like colored patterns, solid and / or mixed color patterns, reflective patterns, iridescent pattern, metallic pattern or potentially any other artistic design or pattern. 在其它实施例中，可使用其它元件将薄膜电池部分地遮盖在镜片内，例如将光电芯片安装到电池前表面，或者作为另外一种选择将电池设置在柔性电路全部或一部分的后面。 In other embodiments, other elements may be used to partially cover the thin film battery within the lens, for example, the optoelectronic chip mounted to the front surface of the battery, or alternatively a battery disposed at the rear of the flexible circuit all or part. 在另外的实施例中，可以统筹考虑地设置薄膜电池，使得电池不是被上眼眼睑就是被下眼睑部分或全部地阻挡而不可见。 In a further embodiment, it may be provided and consider a thin film battery such that the battery is not being touched upon the eyelid to be the lower eyelid partially or wholly blocked from view. 对于本领域技术人员显而易见的是，存在多个与通电眼科装置的外观相关的实施例并存在多种限定这些实施例的方法。 Apparent to the skilled person that there are multiple embodiments of an energized ophthalmic apparatus related to the appearance of the various embodiments and methods limited to these embodiments exist.
已经描述了多个与形成各种通电眼科装置的方法相关的实施例。 Having described the various methods of forming a plurality of related energized ophthalmic device embodiment. 在一组实施例中，本文的发明技术可包括以单独步骤来组装具体通电眼科镜片实施例的子元件。 In one set of embodiments, the inventive art herein may include the step of assembling a separate sub-elements specific embodiment of the power ophthalmic lens embodiment. 结合生物相容性、惰性、保形涂层“离线”组装有利地成形的薄膜微电池、柔性电路、互连线、微电子元件、和/或其它电活性元件，从而提供全包括的可嵌入单封装，该封装可简单地并入标准接触镜片制造方法中。 Binding biocompatible, inert, conformal coating "off-line" assembly of advantageously shaped thin film microbatteries, flexible circuits, interconnects, microelectronic components, and / or other electrically active elements, thereby providing full embedded included single package, which can be easily incorporated into the standard contact lens manufacturing method. 柔性电路可包括由包铜聚酰亚胺薄膜或其它类似基底制造的那些。 The flexible circuits may include those fabricated from copper clad polyimide film or other similar substrates. 保形涂层可包括(但不限于)聚对二甲苯(等级N、C、D、HT以及它们的任何组合)、聚(对苯撑二甲基)、电介质涂层、有机硅保形涂层或任何其它有利的生物相容性涂层。 Conformal coatings may include (but are not limited to) parylene (grades N, C, D, HT, and any combinations thereof), poly (p-xylylene), dielectric coatings, silicone conformal coating layer, or any other advantageous biocompatible coatings.
本发明的一些实施例可为用于薄膜微电池几何形状设计的方法，所述几何形状适从于嵌入眼科镜片材料和/或用眼科镜片材料封装。 Some embodiments of the method of the present invention can be designed for a thin film microbattery geometry, the geometry of the ophthalmic lens suitable material and / or embedded in the package with the ophthalmic lens material. 其它实施例可涉及将薄膜微电池装配在多种材料中的方法，材料例如(但不限于)水凝胶、有机硅水凝胶、刚性可透气“RGP”接触镜片材料、有机硅、热塑性聚合物、热塑性弹性体、热固性聚合物、保形电介质/绝缘涂层，以及不透气封闭涂层。 Other embodiments may relate to a method of assembling a thin film microbatteries in various materials, materials such as (but not limited to) hydrogels, silicone hydrogels, rigid gas permeable "RGP" contact lens materials, silicones, thermoplastic polymer , thermoplastic elastomers, thermosetting polymers, conformal dielectric / insulating coatings, and hermetic seal coating.
其它实施例可涉及在眼科镜片几何体内统筹地放置能量源和光源的方法。 Other embodiments may involve methods ophthalmic lens Energy Source placed in the geometric body and a light source integrated manner. 特别是在一些实施例中，能量源和光源可以为不透明制品。 In particular, in some embodiments, the energy source and the light source may be an opaque article. 由于能量源和光源不可阻碍光透射穿过眼科镜片，因此一些实施例中的设计方法确保接触镜片中心的5-8mm不被能量源和光源的任何不透明部分遮挡。 Since the energy source and the light source is not affected by light transmitted through the ophthalmic lens, so the design of some embodiments of the method to ensure 5-8mm not obstructed by any opaque portions of the light energy source and the center of the contact lens. 对于本领域技术人员显而易见的是，会存在与各种能量源和光源的设计有关的许多不同实施例，以使这些设计与眼科镜片的涉及光学的部分有利地相互配合。 The skilled person will be apparent that there will be many different embodiments and design of various energy sources and associated light sources, so that these portions to optical design advantageously cooperating with an ophthalmic lens.
在一些实施例中，能量源的质量和密度可有利于设计，使得所述能量源既可以单独发挥作用，也可以与设计在眼科镜片主体内的其它镜片稳定区结合使用，从而当镜片佩戴在眼睛上时，镜片稳定区可以旋转方式稳定镜片。 In some embodiments, the mass and density of the energy source may facilitate the design, such that the energy source to function alone may be used in combination with other lens may be designed into the stable region of the ophthalmic lens body, such that when the lens is worn when the eye, the lens stable region can be stabilized lens rotational manner. 此类实施例可有利于多种应用，包括(但不限于)散光校正、改善佩戴于眼睛上时的舒适度，或协调/控制通电眼科镜片内其它元件的位置。 Such embodiments may facilitate a variety of applications, including (but not limited to) the correction of astigmatism, improved comfort when worn on the eye, or to coordinate / control the position of the other elements within the energized ophthalmic lens.
在另外的实施例中，能量源和光源可被设置为与接触镜片的外边缘有一定距离，以有利于接触镜片边缘轮廓的设计，从而提供良好的舒适度，同时将不良事件的发生降至最低。 In further embodiments, the energy source and the light source may be disposed in contact with the outer edge of the lens a certain distance, in order to facilitate the design of the contact lens edge profile in order to provide good comfort while reduced occurrence of adverse events lowest. 此类要避免的不良事件的例子可包括上方上皮弧形侵蚀或巨乳头性结膜炎。 Examples of such adverse events to be avoided may include superior epithelial arcuate erosion or giant papillary conjunctivitis.
通过一些实施例中的非限制性例子，嵌入式电化学电池的阴极、电解质和阳极特征可通过将合适的油墨印刷成形来限定此类阴极、电解质和阳极区域。 By way of non-limiting example, in some embodiments embodiments, the embedded cathode electrochemical cell, the anode and the electrolyte may be characterized by a suitable printing ink formed to define such cathode, electrolyte and anode regions. 显而易见的是，由此形成的电池可包括基于例如锰氧化物和锌化物的单次使用电池，和基于锂化物(类似于上述薄膜电池化学物质)的可再充电薄电池。 It is apparent that batteries thus formed may comprise, for example, based on a single use batteries, lithium-based compound and the manganese oxide and the zinc compound (similar to the thin film battery chemistry) rechargeable thin batteries. 对于本领域技术人员而言显而易见的是，形成通电眼科镜片的各种特征和方法的多种不同实施例可涉及印刷技术的使用。 Those skilled in the art will be apparent that formed using printing techniques may involve many different embodiments and methods of the various features of an energized ophthalmic lens.
现在参见图10，横截面视图1000包括通电眼科镜片1001(也被称为接触镜片1001)，该镜片具有将光1003直射到眼睛1005的角膜1004上的嵌入式光源1002。 Referring now to FIG. 10, a cross-sectional view of an energized ophthalmic lens comprising 1000 1001 (also referred to as a contact lens 1001), the lens 1003 having a direct light onto the cornea of ​​the eye 10041005 1002 embedded source. 在一些实施例中，横截面视图1000可为俯视图，其中一个或多个嵌入式光源1002设置在靠近接触镜片1001的侧面处。 In some embodiments, a cross-sectional view 1000 may be a plan view, wherein the one or more embedded light sources 1002 disposed on the side near the contact lenses at 1001. 在其它实施例中，横截面视图1000可为侧视图，使得一个或多个嵌入式光源1002设置在靠近接触镜片1001的顶部和底部处。 In other embodiments, the cross-sectional side view 1000 may be such that one or more embedded light sources 1002 disposed near the top and bottom of the contact lens 1001. 多个光源1002和光源1002环绕接触镜片1001周边的排列方式可以不同。 Arrangement of a plurality of light sources 1002 and 1002 around the periphery of the contact lens 1001 may be different. 光源1002直接照射佩戴者的眼睛，使得对于观察者来说光照并不明显。 The light source 1002 directly irradiated wearer's eye, so that light is not apparent to the observer. 接触镜片1001也可包括能够遮蔽易被观察者注意到的光疗发光的涂层，而不会减少用户的光疗或视力。 1001 may also include a contact lens capable of easily shielding an observer noted the emitting phototherapy coating without reducing the user's vision or phototherapy.
嵌入式光源1002包括发光二极管(LED)或发出用于光疗法的光1003的其它光源1002。 1002 embedded light source comprises a light emitting diode (LED) or other light source 1002 emits light 1003 for the light therapy. 光源1002可以包括发光二极管(LED)或其它可以发出波长为450至500纳米，更优选470至480纳米以及2,000至3,000勒的蓝光的其它光源。 The light source 1002 may include a light emitting diode (LED) or other may emit wavelengths of 450 to 500 nanometers, more preferably from another light source, and blue 470 to 480 nanometers to 3,000 of 2,000 lux. 或者，LED或其它光源可以发出波长为475至525纳米，更优选490至510纳米以及300至400勒的绿光。 Alternatively, LED or other light source may emit a wavelength of 475-525 nm, more preferably 490 to 510 nanometers and 300 to 400 lux green. 另一个实施例包括单独的光源，其发出的光被输送到接触镜片1001中的一个或多个位置，从而提供照明。 Another embodiment includes a separate light source, the light emitted is transported to a contact lens or a plurality of positions 1001 to provide illumination.
接触镜片1001包括未示出的具有诸如光传感器、能量源、电容器、存储器、处理器和通信装置的元件的支承电子器件。 Contact lens 1001 comprises a support element such as an electronic device having a light sensor, an energy source, a capacitor, a memory, a processor and a communication device (not shown). 光传感器用于检测环境白光、蓝光或绿光。 A light sensor for detecting ambient white light, blue or green. 能量源和电容器为通电眼科镜片的其它元件提供能量。 The energy source and the capacitor providing energy for the other elements of the energized ophthalmic lens. 通过非限制性例子，存储器可以用于存储预编程的光疗时间表，存储光传感器捕集的数据，存储实际光疗日期、时间、持续时间和强度，以及存储与光源和光传感器操作相关的数据以检测装置失效。 By way of non-limiting example, the memory may be used to store pre-programmed light therapy schedule, data storage photosensor trapped, phototherapy store actual date, time, duration and strength, as well as data associated with the operation of the light source and the light sensor to detect device failure. 处理器可以用于例如运行存储在存储器中的程控光疗时间表，分析光传感器数据和根据佩戴者在环境光中的暴露确定独特的光疗时间表，评估对程控光疗时间表的手动更改并提供补偿调整，以及分析光源和光传感器数据以检测设备失效。 The processor can be programmed, for example, light therapy schedule stored in memory to run, analyzing light sensor data and determines the schedule according to a unique light therapy wearer is exposed to ambient light, light assess changes manually programmed therapy schedule and compensation adjustment, and a light source and analyzing sensor data to detect a failure of the device.
通信装置可用于对以下一者或多者进行电子控制：相对于通电眼科镜片和外部装置往返传输数字数据，以及在通电眼科镜片中的元件之间传输数字数据。 The communication device may be used for electronically controlling one or more of the following: a digital transmission between the energized ophthalmic lens trip transmission digital data and an external device, and an element in the energized ophthalmic lens with respect to the data. 通信装置可用于(诸如通过非限制性例子的方式)与一个或多个外部装置，遥控钥匙、个人数字助理(PDA)或用于控制通电眼科镜片的智能手机应用程序进行无线通信。 A communication device may be used (such as by way of non-limiting example) with one or more external devices, remote keyless entry, a personal digital assistant (PDA) or smart phone application for controlling an energized ophthalmic lens for wireless communication. 通电眼科镜片内，元件之间的通信可以通过物理连接诸如直接的导电通路，或可以是无线的。 Within the energized ophthalmic lens, the communication between the conductive path elements may be connected directly such as by physical, or may be wireless. 内部元件之间的通信可包括例如控制处理器中的光源以及光传感器和存储器之间的数据传输。 Communication between the internal components may comprise, for example, controls data transfer between the processor and the memory light source and a light sensor.
支承电子器件与包含在接触镜片1001中的光源1002进行逻辑和电通信。 Supporting an electronic device includes a light source 1002 and 1001 in the contact lens logical and electrical communication. 通过支承电子器件和光源1002之间的直接的导电通路或通过无线通信进行通信。 Communicate via a direct conductive path between the support and the light source 1002 or the electronic device by wireless communication. 无线通信模式可包括例如通过接触镜片1001中邻近光源1002的天线，以及通过将功率从接触镜片1001的另一个区域传输至天线上的电源实现的电感。 The wireless communication mode may include, for example, a contact lens by the light source 1001 adjacent to the antenna 1002, and through the inductor to the power supply on the antenna to achieve a transmission from another region of the contact lens 1001.
在一些实施例中，支承电子器件可包括在遥控钥匙、首饰、帽子、衣物或使用者佩戴的其它物品中，使得光传感器检测使用者经受的环境光，并且支承电子器件邻近接触镜片以便进行无线通信。 In some embodiments, the electronic device may support other items included in the remote control keys, jewelry, hat, clothing or worn by the user, the ambient light sensor that detects the user experienced by the electronic device and supports a contact lens for near radio communication. 无线通信模式可包括例如电感。 The wireless communication mode may include, for example, an inductor. 电感可通过位于接触镜片中的天线以及电源实现，所述电源将功率从首饰、衣物或其它邻近天线的物品中的支承电子器件传输至所述天线。 The inductor may be implemented in a contact lens located through an antenna and a power supply, the power supply from the support jewelry, clothing or other items adjacent to an antenna of the electronic device is transmitted to the antenna.
在一些实施例中，用户可以使用外部装置诸如遥控钥匙、个人数字助理或智能手机应用程序来调节光疗法的时间选择、持续时间和强度。 In some embodiments, the user may use an external device such as a key fob, a personal digital assistant or smartphone application to adjust the timing of light therapy, duration and intensity. 一些实施例提供了基本的运行状态，其中用户可以手动控制光疗法以在适当的时间开始和结束治疗。 Some embodiments provide a basic operational states, where the user can manually control the light therapy at the appropriate time to start and end of treatment.
根据本发明实施例，程控的光疗时间表可以根据变量诸如日期、地理区域和用户的季节性情绪失调症状的严重性来自动调节例如光疗法的时间选择、持续时间和强度。 According to an embodiment of the present invention, programmed light therapy schedule may be automatically adjusted according to the severity of the symptoms of seasonal affective disorder geographic area and user variables such as the date, for example, light therapy timing, duration and intensity. 程控的光疗时间表可由眼部护理专业人员、医师或使用者设定。 Programmed light therapy schedule set by eye care professionals, physicians or users. 在程控的光疗过程中，可能理想的是，用户可以根据活动来调节光强度，例如当阅读、用计算机工作或开车时降低光强度。 In the process of programmed light therapy, it may be desirable, the user can adjust the light intensity based on the activity, such as reducing the light intensity reading, driving or when working with a computer. 反之，当工作休息期间、午饭休息期间或其它较少视觉活动的时间内提高光强度是可取的。 Conversely, when the time during which the work rest, during a lunch break or other visual activity increases less light intensity is desirable. 在一些实施例中，当处理器估算对程控光疗时间表的手动更改并对治疗的持续时间和强度提供补偿调整时实现智能光疗法。 Intelligent light therapy In some embodiments, when the processor changes the estimated duration and intensity of treatment and light therapy schedule manually programmed to provide compensation adjustment. 在另外的实施例中，当用处理器分析得自光传感器的数据，并且基于佩戴者在环境光中的暴露对程控的光疗时间表进行动态调节时实现智能光疗法。 In a further embodiment, the intelligent light therapy when the data obtained from the light sensor, and based on the wearer's exposure to light therapy schedule programmed dynamically adjusted in ambient light by the processor analyzes.
在本发明的另一个实施例中，用户可以根据血液中褪黑激素水平的测试结果对光疗进行手动调节。 In another embodiment of the present invention, a user may manually adjustable to the melatonin levels in the blood test results phototherapy. 光照能够抑制松果体产生褪黑激素，黑暗则刺激松果体产生褪黑激素。 Light generation can be suppressed pineal melatonin, the pineal gland to stimulate the dark to produce melatonin. 较高水平的褪黑激素会使人困倦和嗜睡，产生季节性情绪失调的症状。 Higher levels of melatonin causes drowsiness and lethargy person, produce symptoms of seasonal affective disorder. 对患者血液中褪黑激素的水平进行分析，并以此作为增加或减少光疗的指导。 Of the patient's blood melatonin levels were analyzed, and as a guide to increase or decrease phototherapy.
在另外的实施例中，用户可以手动调节光疗从而有意的改变他们的睡眠周期。 In a further embodiment, the user can manually adjust phototherapy thereby intentionally alter their sleep cycle. 利用光疗法改变睡眠周期对于夜班工作者、在明显不同的时区旅行的人、准备夜间作战的军事人员以及其它应用非常有用。 Using light therapy to change the sleep cycle for night shift workers, people in different time zones obviously traveling, night combat ready military personnel, and other useful applications. 另外，由使用者觉醒时所启用的光疗法可用于治疗昼夜节律性睡眠障碍，例如睡眠相位后移症候群(DSPS)和非24小时制睡眠-觉醒综合征。 Further, from the awakening the user the enabled light therapy useful for treating circadian rhythm sleep disorders such as delayed sleep phase syndrome (of DSPS) and non-24-hour sleep - wake syndrome.
在一些实施例中，光源1002可以将光1003直接射入到嵌有所述光源1002的接触镜片1001的内部。 In some embodiments, the light source 1002 may be directly incident on the light 1003 to the light source is embedded inside the contact lens 1001 1002. 光1003可以直接射入到光散射区域(未示出)，该区域包括衍射特性、折射特性、反射特性或衍射、折射和反射特性的任意组合。 1003 may directly enter the light into the light scattering region (not shown), which region comprises a diffraction properties, refractive properties, reflective or diffractive properties, any combination of refraction and reflection characteristics. 光散射区域可以在接触镜片1001的周边区域内形成环面。 Light scattering region may be formed in the peripheral region of the annulus 1001 of a contact lens. 穿透光散射区域的光1003引起在眼睛1005的角膜1004上形成总体上较宽的光1003的散射。 1003 light scattering transmitted light caused by a wide area generally scattered light 1003 is formed on the cornea of ​​the eye 10,041,005.
在一些优选的实施例中，接触镜片1001可包括环绕在镜片周边的光散射区域和镜片中部的光学区之间的内部屏障。 In some preferred embodiments, the contact lens 1001 may include an internal barrier between the light scattering of the optical zone of the lens and the central region around the periphery of the lens. 内部屏障阻止了用于光疗法的光1003分散到接触镜片1001的光学区。 Inner barrier prevents light optical zone 1003 for light therapy contact lens dispersed in 1001. 这样，用于光疗法的光1003只是分散在角膜1004的周边，最大限度地减小其对正常视觉的影响。 Thus, the light phototherapy for 1003 only peripheral corneal dispersed in 1004, to minimize their impact on normal vision.
在另外的实施例中，整个接触镜片1001包括诸如衍射、折射或反射的光散射特性。 In a further embodiment, the entire contact lens, such as 1001 includes diffraction, refraction or reflection of light scattering properties. 设计光散射特性，使其只分散嵌入式光源1002发出的波长的光1003。 Design of light scattering properties, so that it only disperses light source 1002 1003 embedded wavelength emitted. 该实施例支持在眼睛1005内用于光疗的光1003波长的最大分散，同时不造成会扭曲视觉的光波长的分散。 This embodiment supports a maximum dispersion wavelength of 1003 light phototherapy in the eye 1005, without causing dispersion distorts the visual wavelengths of light.
如上所述以及如下文权利要求所限定，本发明提供了具有进行光疗法所需光源的眼科镜片的加工方法和实施此类方法的设备，以及通过这些方法和设备成形的眼科镜片。 As described above and as defined in the claims, the present invention provides a method of processing an ophthalmic lens having a light source required for light therapy methods and apparatus of such embodiments, and by a method and apparatus for forming such ophthalmic lens.
1.一种形成位于眼睛内或眼睛上的镜片的方法，所述方法包括： A method of forming or located in the eye lens on the eye, the method comprising:
将能量源置于与邻近第一模具部件的光源电连通； The energy source is placed in communication with the light source adjacent to the first electrically mold member;
将反应性单体混合物沉积到所述第一模具部件中； The reactive monomer mixture is deposited into a first mold part;
将所述能量源和光源定位于与所述反应性单体混合物接触，使得来自光源的光被引入镜片的光散射区域，其中镜片的光散射区域造成来自光源的光总体上宽地分散至眼睛上； Said energy source and a light source positioned in contact with the reactive monomer mixture, such that the light from the light source is introduced into the light scattering region of the lens, wherein the light-scattering region of the lens to the eye caused by the wide dispersion of the light from the light source generally on;
将所述第一模具部件定位于邻近第二模具部件，从而形成镜片腔体，所述镜片腔体中具有所述能量源和光源以及至少一些反应性单体混合物；以及 The first mold part is positioned proximate to the second mold part thereby forming a lens cavity with the lens cavity and the energy source having a light source and at least some of the reactive monomer mixture; and
将所述反应性单体混合物暴露于光化辐射。 The reactive monomer mixture is exposed to actinic radiation.
2.根据权利要求1所述的方法，其中所述能量源包括电化学电池。 2. The method according to claim 1, wherein said energy source comprises an electrochemical cell.
3.根据权利要求2所述的方法，其中所述能量源能够为所述光源提供电力以从所述光源发光。 3. The method according to claim 2, wherein said energy source is capable of providing power to the light emitting from the light source to the light source.
4.根据权利要求2所述的方法，其中所述能量源物理性地附接到基底，并且所述基底被置于与所述第一模具部件和所述第二模具部件中的一者或二者接触。 The method according to claim 2, wherein said energy source is physically attached to the substrate, and the substrate is placed in the first mold part and the second mold part of one or both contacts.
5.根据权利要求4所述的方法，其中所述基底包括集成电路，并且所述方法还包括将所述能量源固定至所述基底的步骤。 The method according to claim 4, wherein said substrate comprises an integrated circuit, and the method further comprises the step of the energy source is fixed to the substrate.
6.根据权利要求5所述的方法，其中所述基底包括多个完全不同的部分。 6. The method as claimed in claim 5, wherein said substrate comprises a plurality of distinct parts.
7.根据权利要求1所述的方法，其中所述能量源包括薄膜电化学电池。 7. The method according to claim 1, wherein said energy source comprises a thin film electrochemical cell.
8.根据权利要求7所述的方法，其中所述电化学电池包括锂离子电池。 8. The method according to claim 7, wherein the electrochemical cell comprises a lithium ion battery.
9.根据权利要求7所述的方法，其中所述电化学电池包含可再充电的固态材料。 9. The method according to claim 7, wherein the electrochemical cell comprises a rechargeable solid state material.
10.根据权利要求7所述的方法，其中所述电化学电池包括具有纳米级晶体的阴极。 10. The method according to claim 7, wherein the electrochemical cell having a cathode comprising nanocrystals.
11.根据权利要求10所述的方法，其中所述纳米级晶体包含磷化铁锂。 11. The method according to claim 10, wherein the nanoscale crystal comprises lithium iron phosphide.
12.根据权利要求1所述的方法，其中所述光源发出波长为450至500纳米的蓝光。 12. The method according to claim 1, wherein said light source emits a wavelength of 450 to 500 nm blue light.
13.根据权利要求12所述的方法，其中所述光源发出波长为470至480纳米的蓝光。 13. The method according to claim 12, wherein said light source emits a wavelength of 470-480 nm blue light.
14.根据权利要求13所述的方法，其中所述光源发出介于约2,000至3,000勒之间的光。 14. The method according to claim 13, wherein said light source of between about 2,000 to 3,000 Le emitted interposed.
15.根据权利要求1所述的方法，其中所述光源发出波长为475至525纳米的绿光。 15. The method according to claim 1, wherein said light source emits a wavelength of 475-525 nm green light.
16.根据权利要求15所述的方法，其中所述光源发出波长为490至510纳米的绿光。 16. The method according to claim 15, wherein said light source emits a wavelength of 490-510 nm green light.
17.根据权利要求16所述的方法，其中所述光源发出介于约300至400勒之间的光。 17. The method according to claim 16, wherein said light source emits light between about 300 to 400 lux interposed.
18.根据权利要求1所述的方法，其中所述光源包括一个或多个发光二极管。 18. The method according to claim 1, wherein said light source comprises one or more light emitting diodes.
19.根据权利要求18所述的方法，其中设备包括一个或多个光管。 19. The method of claim 18, wherein the device comprises one or more light pipes.
20.根据权利要求19所述的方法，其中所述一个或多个光管包括光纤通道。 20. The method according to claim 19, wherein said light pipe comprises one or more Fiber Channel.
21.根据权利要求1所述的方法，其中所述镜片包括环绕镜片光学区周边的环状的区域，能量源和光源位于所述环状的区域内。 21. A method according to claim 1, wherein said lens comprises an annular surrounding the periphery of the optic zone of the region, the energy source and a light source located within the annular region.
22.根据权利要求21所述的方法，其中镜片中心的5mm不被能量源和光源的任何不透明部分遮挡。 22. The method of claim 21, wherein 5mm is not obstructed by any opaque portions of the energy source and the light source center of the lens.
23.根据权利要求21所述的方法，其中光源将光照引向眼睛，使得对于观察者来说光照不明显。 23. The method according to claim 21, wherein the light source towards the eye, so that light is not obvious to the viewer.
24.根据权利要求21所述的方法，其中光散射区域将来自光源的光引导至眼睛的角膜上。 24. The method according to claim 21, wherein the light-scattering region of the light source directed onto the cornea from the eye.
25.根据权利要求24所述的方法，其中光散射区域在镜片的周边区域内形成环面。 25. The method of claim 24, wherein the light-scattering region is formed in the peripheral region of the annulus of the lens.
26.根据权利要求21所述的方法，其中镜片包括环绕镜片周边的光散射区域和镜片中部的光学区之间的内部屏障。 26. The method according to claim 21, wherein the lens comprises an inner barrier between the light-scattering lens central optical region and a region around the lens periphery.
27.根据权利要求21所述的方法，其中将能量源置于与邻近第一模具部件的光源电连通的步骤还包括邻近所述第一模具部件放置记忆储存装置和处理器。 27. The method according to claim 21, wherein the step of placing the energy source and the light source is electrically adjacent to the first mold part further comprises a communication member disposed adjacent to the first mold memory storage device and a processor.
28.根据权利要求27所述的方法，其中所述处理器能确定操作光源的时间表。 28. The method according to claim 27, wherein the processor is capable of determining the operation schedule of the light source.
CN201280007438.1A 2011-02-04 2012-02-02 Forming an energized ophthalmic device and method for a light therapy device CN103338816B (en)
US201161439535P true 2011-02-04 2011-02-04
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PCT/US2012/023663 WO2012106535A1 (en) 2011-02-04 2012-02-02 Apparatus and method for formation of an energized ophthalmic device for light therapy
CN103338816A CN103338816A (en) 2013-10-02
CN103338816B true CN103338816B (en) 2016-10-26
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