Source: http://www.google.ca/patents/US8743369
Timestamp: 2018-01-22 14:37:23
Document Index: 386851422

Matched Legal Cases: ['art4', 'art4', 'Application No. 02808314', 'Application No. 02808314', 'Application No. 02808314', 'Application No. 2004', 'Application No. 2004', 'Application No. 2', 'Application No. 2004']

Patent US8743369 - Surface plasmon resonance sensor - Google Patents
An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected...http://www.google.ca/patents/US8743369?utm_source=gb-gplus-sharePatent US8743369 - Surface plasmon resonance sensor
Publication number US8743369 B2
Application number US 13/966,364
Also published as CA2511934A1, CA2511934C, DE60232689D1, EP1581800A1, EP1581800B1, US7443507, US7586616, US7999942, US8111400, US8363223, US20060072113, US20080198384, US20090296095, US20110267622, US20120113428, US20130196448, US20130330838, WO2004059301A1
Publication number 13966364, 966364, US 8743369 B2, US 8743369B2, US-B2-8743369, US8743369 B2, US8743369B2
Patent Citations (72), Non-Patent Citations (53), Classifications (6), Legal Events (3)
US 8743369 B2
1. A surface plasmon resonance (SPR) system using a ligand, the system comprising:
a) a thin conducting layer suitable for SPR formed on a transparent substrate, the conducting layer comprising a plurality of electrodes;
b) at least one flow channel crossing the electrodes at crossover regions;
c) a power supply connected to the electrodes, and differently electrifying the electrodes at two different cross-over regions, such that the ligand flowing through the flow channel is attracted to and immobilized on the electrode at one of the cross-over regions, and repelled by and substantially prevented from immobilizing on the electrode at the other of the cross-over regions; and
d) a photosensitive surface that generates SPR signals in response to light reflected from the crossover region at which the ligand is immobilized, that can be used to determine an SPR parameter, and generates reference SPR signals in response to light reflected from the crossover region at which the ligand is prevented from immobilizing, that can be used to normalize and correct the SPR signals from the crossover region at which the ligand is immobilized.
2. A system according to claim 1, wherein the at least one flow channel comprises a plurality of flow channels.
3. A system according to claim 2, wherein the electrodes comprise a strip electrode crossed by the plurality of flow channels.
4. A system according to claim 2, wherein the electrodes comprise a pixel electrode crossed by only one of the flow channels.
5. A method for characterizing an interaction of a target material with a ligand on an SPR surface, the method comprising:
a) electrifying a first electrode comprising a conducting layer suitable for SPR formed on a transparent substrate, so that it attracts the ligand;
b) electrifying a second electrode differently from the first electrode, so that it repels the ligand, the second electrode also comprising a conducting layer suitable for SPR formed on a transparent substrate;
c) passing a fluid containing the ligand through a flow channel crossed by the first and second electrodes while electrifying them, immobilizing the ligand on the first electrode and substantially not on the second electrode;
d) passing the target material through the flow channel after the ligand has been immobilized;
e) detecting light reflected from the first and second electrodes, after passing at least some of the target material through the flow channel;
f) generating SPR signals from the detected light reflected from the first electrode, and SPR reference signals from the detected light reflected from the second electrode; and
g) determining an SPR parameter that characterizes the interaction from the SPR signals, normalized and corrected by the SPR reference signals.
6. A method according to claim 5, also comprising:
a) electrifying a third electrode, comprising a conducting layer suitable for SPR formed on a transparent substrate, that also crosses the fluid channel, after the ligand is immobilized on the first electrode, while passing fluid containing a second ligand through the flow channel, so that the second ligand is attracted to and immobilized on the third electrode, and electrifying the first and second electrodes differently so that the second ligand is repelled by and substantially not immobilized on the first and second electrodes;
b) detecting light reflected from the third electrode, after passing at least some of the target material through the flow channel;
c) generating additional SPR signals from the detected light reflected from the third electrode; and
d) determining an SPR parameter characterizing an interaction of the target material with the second ligand from the additional SPR signals.
7. A system according to claim 3, wherein the strip electrode is about 100 μm in width.
8. A system according to claim 3, wherein the electrodes comprise a plurality of substantially parallel strip electrodes repeating at a pitch of about 200 μm.
9. A system according to claim 3, wherein the electrodes comprise about 100 substantially parallel strip electrodes.
10. A method according to claim 5, wherein the first electrode is a strip electrode crossed also by a second flow channel, the method also comprising:
a) passing a fluid containing a second ligand, which has a polarity charge of a same sign as the first ligand, through the second flow channel while the first electrode is electrified so that it attracts the first and second ligands, immobilizing the second ligand on the first electrode where it is crossed by the second flow channel;
b) passing a second target material, the same as or different from the first target material, through the second flow channel after the second ligand has been immobilized;
c) detecting light reflected from the first electrode where it is crossed by the second flow channel, after passing at least some of the second target material through the second flow channel;
d) generating second SPR signals from the detected light reflected from the first electrode where it is crossed by the second flow channel; and
e) determining a second SPR parameter that characterizes an interaction of the second target material with the second ligand, from the SPR signals.
11. A method according to claim 10, wherein the second electrode is also a strip electrode crossed also by the second flow channel, the second ligand being repelled by the second electrode and substantially not immobilized on it when it is electrified differently from the first electrode, and the method also comprises detecting light reflected from the second electrode where it is crossed by the second flow channel and generating second SPR reference signals from said detected light, and determining a second SPR parameter that characterizes the interaction of the second target material with the second ligand comprises normalizing and correcting the second SPR parameter from the second reference signals.
12. A method according to claim 5, wherein the first electrode is a strip electrode crossed also by a second flow channel, the method also comprising:
a) electrifying the first electrode so it repels the first ligand, at a different time than when the first electrode is electrified so it attracts the first ligand;
b) passing a fluid containing a second ligand, which has a polarity charge of an opposite sign to the first ligand, through the second flow channel while the first electrode is electrified so that it repels the first ligand and attracts the second ligand, immobilizing the second ligand on the first electrode where it is crossed by the second flow channel;
c) passing a second target material, the same as or different from the first target material, through the second flow channel after the second ligand has been immobilized;
d) detecting light reflected from the first electrode where it is crossed by the second flow channel, after passing at least some of the second target material through the second flow channel;
e) generating second SPR signals from the detected light reflected from the first electrode where it is crossed by the second flow channel; and
f) determining a second SPR parameter that characterizes an interaction of the second target material with the second ligand, from the SPR signals.
13. A method according to claim 12, wherein, after one of the two ligands is immobilized on the first electrode, and it is electrified so it repels the already immobilized ligand and attracts the other ligand, the first electrode is not electrified so strongly that the already immobilized ligand is removed from it.
14. A surface plasmon resonance (SPR) system comprising:
a) a thin conducting layer suitable for SPR formed on a transparent substrate, the conducting layer comprising a number of conducting strips about 100 μm in width;
b) a plurality of flow channels crossing the conducting strips at crossover regions;
c) an illumination system configured to illuminate an interface of the conducting layer and the substrate at the crossover regions, and at other regions of the conducting strips that are not crossover regions, at a plurality of different angles of incidence or different wavelengths; and
d) a photosensitive surface that generates SPR signals in response to light reflected from the illuminated crossover regions that can be used to determine an SPR parameter, and generates reference SPR signals in response to light reflected from the other regions, that can be used to normalize or correct the SPR signals from the crossover regions.
This application is a continuation of U.S. patent application Ser. No. 13/751,175 filed on Jan. 28, 2013, which is a continuation of U.S. patent application Ser. No. 13/348,663 filed on Jan. 12, 2012, now U.S. Pat. No. 8,363,223, which is a continuation of U.S. patent application Ser. No. 13/181,547 filed on Jul. 13, 2011, now U.S. Pat. No. 8,111,400, which is a division of U.S. patent application Ser. No. 12/535,707 filed on Aug. 5, 2009, now U.S. Pat. No. 7,999,942, which is a continuation of U.S. patent application Ser. No. 12/149,158 filed on Apr. 28, 2008, now U.S. Pat. No. 7,586,616, which is a division of U.S. patent application Ser. No. 10/540,940 filed on Jun. 23, 2005, now U.S. Pat. No. 7,443,507, which is a National Phase of PCT Patent Application No. PCT/IL2002/001037 filed on Dec. 25, 2002. The contents of all of the above applications are incorporated herein by reference.
Liquids are introduced into microchannels 36 of flow cell 34 shown in FIG. 1A either through their respective inlet segments 55 or by injection through flow needles 42. Each microchannel 36 is associated with its own flow needle 42 and position of the flow needle determines whether liquid from inlet segment 55 or from flow needle 42 flows in the microchannel. Each microchannel 36 is also associated with its own drain microchannel 59. A microchannel 36 and its drain microchannel 59 are not connected by a flow channel formed in the flow cell 34.
US5341215 28 May 1992 23 Aug 1994 Hewlett-Packard Company Method and apparatus for detecting the presence and/or concentration of biomolecules
US5694930 19 Aug 1993 9 Dec 1997 Yoon-Ok Kim Device for qualitative and/or quantative analysis of a sample
US5770462 27 May 1994 23 Jun 1998 Fisons Plc Analytical apparatus
US5907408 30 Apr 1997 25 May 1999 Fuji Photo Film Co., Ltd. Surface plasmon sensor
US5917607 24 Apr 1997 29 Jun 1999 Fuji Photo Film Co., Ltd. Surface plasmon sensor for multiple channel analysis
US5917608 29 Apr 1998 29 Jun 1999 Fuji Photo Film Co., Ltd. Surface plasmon sensor
US5926284 29 Apr 1998 20 Jul 1999 Fuji Photo Film Co., Ltd. Surface plasmon sensor
US6008893 22 Mar 1999 28 Dec 1999 Biacore Ab Reversible-flow conduit system
US6570657 6 Apr 1999 27 May 2003 Institut Fuer Physikalische Hochtechnolgolie E.V. Arrangement for surface plasmon resonance spectroscopy
US6738141 28 Jan 2000 18 May 2004 Vir A/S Surface plasmon resonance sensor
US7535570 7 Oct 2005 19 May 2009 Fujifilm Corporation One dimensional measuring unit having a dielectric block
US20030076501 9 May 2001 24 Apr 2003 Andreas Hofmann Plasmon resonance sensor
US20060072113 25 Dec 2002 6 Apr 2006 Boaz Ran Surface plasmon resonance sensor
US20080198384 28 Apr 2008 21 Aug 2008 Bio-Rad Haifa Ltd. Surface plasmon resonance sensor
US20090296095 5 Aug 2009 3 Dec 2009 Bio-Rad Laboratories Inc. Surface plasmon resonance sensor
US20120113428 12 Jan 2012 10 May 2012 Bio-Rad Laboratories Inc. Surface plasmon resonance sensor
US20130196448 28 Jan 2013 1 Aug 2013 Bio-Rad Laboratories Inc. Surface plasmon resonance sensor
EP0305109A1 18 Aug 1988 1 Mar 1989 AMERSHAM INTERNATIONAL plc Biological sensors
EP0341928A1 5 May 1989 15 Nov 1989 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
EP0442921A1 9 Nov 1989 28 Aug 1991 Pharmacia Biosensor Ab Optical biosensor system.
EP0867697A1 30 Oct 1996 30 Sep 1998 Kyoto Dai-ichi Kagaku Co., Ltd. Light source apparatus and measurement method
EP0938661A1 5 Nov 1997 1 Sep 1999 The Secretary Of State For Defence Analytical apparatus
EP1068511A1 6 Apr 1999 17 Jan 2001 Analytik Jena GmbH, Analysenmessgeräte und Laboreinrichtungen Arrangement for surface plasmon resonance spectroscopy
JP2001504582A Title not available
JP2001526386A Title not available
JP2002540405A Title not available
JPH0364313A Title not available
JPH1137929A Title not available
JPH1144647A Title not available
JPH01224647A Title not available
JPH03294605A Title not available
JPH03503806A Title not available
JPH09126888A Title not available
JPH09292332A Title not available
WO1990005317A1 9 Nov 1989 17 May 1990 Pharmacia Ab Optical interface means
WO1990009576A1 29 Jan 1990 23 Aug 1990 Plessey Overseas Limited A method for detecting optical phase changes during biosensor operation, biosensing apparatus and a biosensor adapted for use in the same
WO1992019984A1 29 Apr 1992 12 Nov 1992 Valtion Teknillinen Tutkimuskeskus Apparatus for locating an object, and light transmitter
WO1998022808A1 5 Nov 1997 28 May 1998 The Secretary Of State For Defence Analytical apparatus
WO1998057149A1 7 May 1998 17 Dec 1998 Petr Ivanovich Nikitin A method of examining biological, biochemical, and chemical characteristics of a medium and apparatus for its embodiment
WO1999030135A1 14 Dec 1998 17 Jun 1999 The Perkin-Elmer Corporation Optical resonance analysis system
WO2000022419A1 6 Apr 1999 20 Apr 2000 Institut für Physikalische Hochtechnologie e.V. Arrangement for surface plasmon resonance spectroscopy
WO2001020295A2 12 Sep 2000 22 Mar 2001 Proteoptics Ltd Plasmon resonance phase imaging
WO2002036485A1 1 Nov 2001 10 May 2002 Biacore Ab Valve integrally associated with microfluidic liquid transport assembly
WO2002055993A2 11 Jan 2002 18 Jul 2002 Univ Boston Use of electrostatic fields to enhance surface plasmon resonance spectroscopy
WO2002063349A2 1 Feb 2002 15 Aug 2002 Research International, Inc. Enhanced waveguide and method
WO2004059301A1 25 Dec 2002 15 Jul 2004 Proteoptics Ltd. Surface plasmon resonance sensor
1 Anonymous "BIAcore Surface Plasmon Resonance (SPR)", 3 P., 2002. http://www.astbury.leeds.ac.uk/Facil/spr.htm.
2 Berger et al. "Surface Plasmon Propagation Near an Index Step", MESA Institute, Applied Optics Group, University of Twente, p. 1-10, 2002, http:/lps.ens.fr/~berger/articles/art4/OptComm/htm.
3 Berger et al. "Surface Plasmon Propagation Near an Index Step", MESA Institute, Applied Optics Group, University of Twente, p. 1-10, 2002, http:/lps.ens.fr/˜berger/articles/art4/OptComm/htm.
4 Berger et al. "Surface Plasmon Resonance Multisensing", Analytical Chemistry, 70(4): 703-706, 1998.
5 Communication Pursuant to Article 96(2) EPC Dated Nov. 2, 2007 From the European Patent Office Re.: Application No. 02808314.5.
6 Communication Pursuant to Article 96(2) EPC Dated Nov. 30, 2006 From the European Patent Office Re.: Application No. 02808314.5.
7 Communication Relating to the Result of the Partial International Search Report Dated Oct. 23, 2003 From the International Searching Authority Re.: Application No. PCT/IL02/01037.
8 Grigorenko et al. "Dark-Field Surface Plasmon Resonance Microscopy", Optics Communications, 174: 151-155, 2000.
9 Grigorenko et al. "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging", Applied Physics Letters, 75(25): 3917-3919, 1999.
10 Herminghaus et al. "Phase Contrast Surface Mode Resonance Microscopy", Quantum Electronics, 112: 16-20, 1994.
11 Homola et al. "Surface Plasmon Resonance Sensors: Review", Sensors and Actuators, B 54: 3-15, 1999.
12 International Preliminary Examination Report Dated Mar. 24, 2005 From the European Patent Office Re.: Application No. PCT/IL02/01037.
13 International Search Report Dated Jan. 14, 2004 From the International Searching Authority Re.: Application No. 02808314.5.
14 Jordan et al. "Surface Plasmon Resonance Imaging Measurements of Electrostatic Biopolymer Adsorption Onto Chemically Modified Gold Surfaces", Analytical Chemistry, 69(7): 1449-1456, 1997.
15 Kabashin et al. "Interferometer Based on a Surface-Plasmon Resonance for Sensor Applications", Quantum Electronics, 27(7): 653-654, 1997.
16 Kabashin et al. "Phase-Polarisation Contrast for Surface Plasmon Resonance Biosensors", Biosensors & Bioelectronics, 13: 1263-1269, 1998.
17 Kabashin et al. "Phase—Polarisation Contrast for Surface Plasmon Resonance Biosensors", Biosensors & Bioelectronics, 13: 1263-1269, 1998.
18 Kabashin et al. "Surface Plasmon Resonance Bio-and Chemical-Sensors With Phase-Polarisation Contrast", Sensors and Actuators, B 54: 51-56, 1999.
19 Kabashin et al. "Surface Plasmon Resonance Interferometer for Bio-and Chemical-Sensors", Optics Comminications, 150: 5-8, 1998.
20 Kochergin et al. "Phase Properties of a Surface-Plasmon Resonance From the Viewpoint of Sensor Applications", Quantum Electronics, vol. 28(5): 444-448, 1998.
21 Kochergin et al. "Visualisation of the Angular Dependence of the Reflected-Radiation Phase Under Conditions of a Surface-Plasmon Resonance and its Sensor Applications", Quantum Electronics, 28(9): 835-839, 1998.
22 Lipson "Experiment Procedure", ProteOptics, Haifa, IL, 2 P. 2002.
23 Lofas et al. "Bioanalysis With Surface Plasmon Resonance", Sensors and Actuators B Chemical, 5(1/4): 79-84, 1991. p. 79, col. 2, Par.2-p. 81, col. 1, Par.2.
24 Marszalec "Modelling and Simulation of an Angular-Scan LED Array-Based Range Imaging Sensor", Proceedings of the 1993 IEEE/RSJ International Conference on Intelligent Robots and Systems, Yokohama, JP, p. 1837-1844, 1993.
25 Marszalec et al. "A LED-Array-Based Range-Imaging Sensor for Fast Three-Dimensional Shape Measurments", Sensors and Actuators A, 46-47: 501-505, 1995.
26 Marszalec et al. "A Photoelectric Range Scanner Using an Array of LED Chips", Proceedings of the 1992 IEEE International Conference on Robots and Automation, Nice, FR, p. 593-598, 1992.
27 Nikitin et al. "Surface Plasmon Resonance Interferometry for Biological and Chemical Sensing", Sensors and Actuators, B 54: 43-50, 1999.
28 Nikitin et al. "Surface Plasmon Resonance Interferometry for Micro-Array Biosensing", Eurosensors XIII, The 13th European Conference on Solid-State Transducers, The Hague, NL, Optical Techniques in (Bio)Chemical Systems, 5A4: 235-238, 1999.
29 Notcovich et al. "Surface Plasmon Resonance Phase Imaging", Applied Physics Letters, 76(13): 1665-1667, 2000.
30 Notice of Allowance Dated Apr. 18, 2011 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/535,707.
31 Notice of Allowance Dated Jan. 29, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/540,940.
32 Notice of Allowance Dated Jun. 4, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/540,940.
33 Notice of Allowance Dated May 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/149,158.
34 Notice of Allowance Dated May 14, 2013 From the US Patent and Trademark Office Re. U.S. Appl. No. 13/751,175.
35 Notice of Allowance Dated Oct. 7, 2011 From the US Patent and Trademark Office Re. U.S. Appl. No. 13/181,547.
36 Notice of Allowance Dated Sep. 28, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 13/348,663.
37 Notification of Reasons of Rejection Dated Jan. 29, 2009 From the Japanese Patent Office Re.: Application No. 2004-563535 and Its Translation Into English.
38 Official Action Dated Aug. 13, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/535,707.
39 Official Action Dated Feb. 29, 2012 From the US Patent and Trademark Office Re. U.S. Appl. No. 13/348,663.
40 Official Action Dated Jun. 15, 2007 From the US Patent and Trademark Office Re.: U.S. Appl. No. 10/540,940.
41 Official Action Dated Nov. 24, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/535,707.
42 Official Action Dated Nov. 30, 2007 From the Japanese Patent Office Re.: Application No. 2004-563535 and Its Translation Into English.
43 Official Action Dated Sep. 17, 2008 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/149,158.
44 Requisition by the Examiner Dated Oct. 5, 2009 From the Canadian Intellectual Property Office Re.: Application No. 2,511,934.
45 Response Dated Feb. 24, 2011 to Official Action of Nov. 24, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/535,707.
46 Response Dated Sep. 7, 2010 to Official Action of Aug. 13, 2010 From the US Patent and Trademark Office Re.: U.S. Appl. No. 12/535,707.
47 Teng et al. "Simple Reflection Technique for Measuring the Electro-Optic Coefficient of Poled Polymers", Applied Physics Letters, 56 (18): 1734-1736, 1990.
48 Texas Instruments "Refractive Index Sensing With Surface Plasmon Resonance: The Kretschmann Geometry", Spreeta Technology Overview, 2 P., 2001.
49 Totzeck et al. "Phase-Shifting Polarization Interferometry for Microstructure Linewidth Measurement", Optic Letters, 24(5): 294-296, 1999.
50 Totzeck et al. "Phase—Shifting Polarization Interferometry for Microstructure Linewidth Measurement", Optic Letters, 24(5): 294-296, 1999.
51 Translation of Notice of Reason(s) for Rejection Dated Nov. 30, 2007 From the Japanese Patent Office Re.: Application No. 2004-563535.
52 Wegner et al. "An Introduction to SPR-Surface Plasmon Resonance", 2 P., 2002. http://www.uksaf.org/tech/spr.html.
53 Written Opinion Dated Nov. 23, 2004 From the International Searching Authority Re.: Application No. PCT/IL02/01037.
Cooperative Classification G01N21/55, G01N21/553, G01N2021/058
Owner name: PROTEOPTICS LTD., ISRAEL
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Owner name: BIO-RAD HAIFA LTD., ISRAEL
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