Source: http://www.google.com/patents/US8133215?ie=ISO-8859-1
Timestamp: 2014-12-27 11:39:28
Document Index: 149575820

Matched Legal Cases: ['Application No. 60', 'Application No. 2002223270', 'Application No. 2', 'Application No. 08253298', 'Application No. 08253298', 'Application No. 01994538', 'Application No. 01973835', 'Application No. 08523298', 'Application No. 08253298']

Patent US8133215 - Independently-manufactured drug delivery module and corresponding receptacle ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsA drug delivery system for an implantable medical device and methods for making and using the same. Embodiments include a housing of an implantable component of the medical device and one or more at least quasi-solid drug-delivery modules that retain an at least quasi-solid state if not a solid state....http://www.google.com/patents/US8133215?utm_source=gb-gplus-sharePatent US8133215 - Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical deviceAdvanced Patent SearchPublication numberUS8133215 B2Publication typeGrantApplication numberUS 12/191,302Publication dateMar 13, 2012Filing dateAug 13, 2008Priority dateAug 13, 2007Also published asUS20090048580, US20120172832Publication number12191302, 191302, US 8133215 B2, US 8133215B2, US-B2-8133215, US8133215 B2, US8133215B2InventorsPeter GibsonOriginal AssigneeCochlear LimitedExport CitationBiBTeX, EndNote, RefManPatent Citations (100), Non-Patent Citations (36), Referenced by (1), Classifications (11), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetIndependently-manufactured drug delivery module and corresponding receptacle in an implantable medical deviceUS 8133215 B2Abstract A drug delivery system for an implantable medical device and methods for making and using the same. Embodiments include a housing of an implantable component of the medical device and one or more at least quasi-solid drug-delivery modules that retain an at least quasi-solid state if not a solid state. The drug-delivery modules and component housing are physically distinct, and as such, may be manufactured independently of each other. The independently-manufacturable drug delivery modules each carry a drug, while the component housing has an exterior surface with one or more recesses formed therein. Associated module(s) and recess(es) are correspondingly dimensioned so that each module may be securely retained within an associated recess via, for example, an interference fit such as by physical interlocking or by friction fit. When so retained in a housing recess, the drug-delivery module and surrounding exterior surface of the housing form a contiguous component surface.
What is claimed is: 1. A drug delivery system for an implantable medical device comprising:
inserting the drug-delivery module into the recess subsequent to the device's manufacture such that the module is secured in the recess as a result of the dimension of the module being sized slightly larger that the corresponding dimension of the recess. Description
CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Application No. 60/955,530, entitled �An Independently-Manufactured Drug Delivery Module And Corresponding Receptacle In An Implantable Medical Device,� filed Aug. 13, 2007 under Attorney Docket No. 22409-00147-US, which is hereby incorporated by reference herein.
Prosthetic hearing devices include a category of implantable devices known as Cochlear� implants (also referred to as Cochlear� devices, Cochlear� implant devices, and the like; �cochlear implants� herein). (COCHLEAR is a trademark of Cochlear Limited, Lane Cove, NSW, Australia.). Cochlear implants include an array of stimulation electrodes which is implanted in the cochlea of the patient (referred to herein as a recipient). The electrode carrier member is controlled by an electronic system encased in a hermetically sealed, biocompatible housing typically implanted in the mastoid. The electronic system, commonly referred to as a stimulator unit, essentially contains decoder and driver circuits for the stimulation electrodes. Acoustic sound reception and conversion of acoustic signals into electrical signals typically occurs externally in a speech processor worn by the recipient. The speech processor superimposes the preprocessed signals, properly coded, on a high frequency carrier signal which is transmitted transcutaneously to the implanted components through the closed skin. A microphone is located outside of the recipient's body, typically in a behind-the-ear housing worn on the auricle.
Traditionally, there has been interest in delivering a bioactive substance or chemical (collectively �drug� herein) in conjunction with implantable medical devices. For example, in one conventional approach the implantable medical device is coated with a drug. In other conventional approaches, a drug is integrated into the polymeric coating of the implantable medical device component. These and other conventional approaches typically require the incorporation of the drug into the material of the implantable medical device during the manufacturing process of the device. This introduces a number of difficult problems and challenges for the manufacturing and sterilization of medical devices, particularly complex medical devices.
SUMMARY In accordance with one aspect of the present invention, a drug-delivery system for an implantable medical device is disclosed, the device comprising: a housing of an implantable component of the medical device having an exterior surface with one or more recesses formed therein; a drug-delivery module that retains at least a quasi-solid state and releasably carries at least one drug; wherein the module and housing are physically distinct, and the module and recess are correspondingly dimensioned such that the module may be securely retained within the recess.
DETAILED DESCRIPTION Aspects of the present invention are generally directed to a drug delivery system for an implantable medical device and methods for making and using the same. Embodiments of the drug delivery system comprise a housing of an implantable component of the medical device and one or more at least quasi-solid drug-delivery modules that retain an at least quasi-solid state if not a solid state. The drug-delivery modules and component housing are physically distinct, and as such, may be manufactured independently of each other. The independently-manufacturable drug delivery modules each carry a drug, while the component housing has an exterior surface with one or more recesses formed therein. Associated module(s) and recess(es) are correspondingly dimensioned so that each module may be securely retained within an associated recess via, for example, an interference fit such as by physical interlocking or by friction fit. When so retained in a housing recess, the drug-delivery module and surrounding exterior surface of the housing form a contiguous component surface.
As used herein, the term �drug� refers to any bioactive substance or chemical now or later developed, including, but not limited to, pharmaceuticals and other chemical compounds such as those intended to provide therapeutic benefits to, or other acute or chronic reactions in, an implant recipient, whether localized or systemic. Such drugs may include, for example, steroids or other anti-inflammatory drugs to reduce inflammation at the implantation site. Other drugs that may be included in the drug delivery modules are antibiotics to mitigate bacterial growth related to the implantation of the medical device. Other drugs may be utilized to increase the performance of the implantable medical device.
Recesses 202A-202C are formed in the bottom surface of rigid housing 228, and are disposed around the outside perimeter of the bottom surface of the housing so as to avoid compromising the hermetic seal of the housing. In contrast, recesses 202D and 202E are disposed in silicone housing 226, around magnet 204, and between turns of internal coil 132, as depicted in FIG. 2C. Thus, as used herein, the terms �implantable component housing,� �housing,� �cover,� and the like, refer to any element of an implantable medical device component that provides an exterior surface for at least a part of the implantable device, and in which a recess may be formed to receive and retain a drug-delivery module.
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Mailed May 27, 2005.36Written Opinion dated 01.28.20021; corresponding PCT/AU01/01479, filed Dec. 2, 2001 published as WO 2002/4166 on May 23, 2002; Applicant Cochlear Limited; Inventor: Peter Gibson.Referenced byCiting PatentFiling datePublication dateApplicantTitleUS8617097May 24, 2010Dec 31, 2013Cochlear LimitedDrug-delivery accessory for an implantable medical deviceClassifications U.S. Classification604/891.1, 604/288.01International ClassificationA61K9/22, A61M37/00Cooperative ClassificationA61N1/37229, A61N1/36032, A61F11/00, A61M31/002European ClassificationA61F11/00, A61N1/36F, A61M31/00DLegal EventsDateCodeEventDescriptionOct 27, 2008ASAssignmentOwner name: COCHLEAR LIMITED, AUSTRALIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GIBSON, PETER;REEL/FRAME:021739/0934Effective date: 20080912RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google