Source: http://www.google.com/patents/US20090076563?dq=6317900
Timestamp: 2017-05-24 08:52:21
Document Index: 369563619

Matched Legal Cases: ['art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115', 'art 115']

Patent US20090076563 - Method and apparatus for treating irregular ventricular contractions such as ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA cardiac rhythm management system is capable of treating irregular ventricular heart contractions, such as during atrial tachyarrhythmias such as atrial fibrillation. A first indicated pacing interval is computed based at least partially on a most recent V-V interval duration between ventricular beats...http://www.google.com/patents/US20090076563?utm_source=gb-gplus-sharePatent US20090076563 - Method and apparatus for treating irregular ventricular contractions such as during atrial arrhythmiaAdvanced Patent SearchTry the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents.Publication numberUS20090076563 A1Publication typeApplicationApplication numberUS 12/325,887Publication dateMar 19, 2009Filing dateDec 1, 2008Priority dateMay 21, 1999Also published asUS8064997, US8135465, US20070016258Publication number12325887, 325887, US 2009/0076563 A1, US 2009/076563 A1, US 20090076563 A1, US 20090076563A1, US 2009076563 A1, US 2009076563A1, US-A1-20090076563, US-A1-2009076563, US2009/0076563A1, US2009/076563A1, US20090076563 A1, US20090076563A1, US2009076563 A1, US2009076563A1InventorsDavid B. Krig, Jesse W. Hartley, Wyatt Stahl, Jeffrey E. StahmannOriginal AssigneeCardiac Pacemakers, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (99), Referenced by (14), Classifications (7), Legal Events (1) External Links: USPTO, USPTO Assignment, EspacenetMethod and apparatus for treating irregular ventricular contractions such as during atrial arrhythmia
[0001] This application is a divisional of U.S. patent application Ser. No. 10/852,602, filed on May 24, 2004, which is a continuation of U.S. patent application Ser. No. 09/316,515, filed on May 21, 1999, now issued as U.S. Pat. No. 7,062,325, the specifications of which are incorporated herein by reference in their entirety.
[0002] This application is related to the following, commonly assigned patent applications: “Cardiac Rhythm Management System Promoting Atrial Pacing,” U.S. Pat. No. 6,351,669; “Cardiac Rhythm Management System With Atrial Shock Timing Optimization,” U.S. Pat. No. 6,430,438; and “System Providing Ventricular Pacing and Biventricular Coordination,” U.S. Pat. No. 6,285,907; each of which were filed on May 21, 1999, each of which disclosure is herein incorporated by reference in its entirety.
[0003] The present system relates generally to cardiac rhythm management systems and particularly, but not by way of limitation, to a method and apparatus for treating irregular ventricular contractions, such as during an atrial arrhythmia.
[0004] When functioning properly, the human heart maintains its own intrinsic rhythm, and is capable of pumping adequate blood throughout the body's circulatory system. However, some people have irregular cardiac rhythms, referred to as cardiac arrhythmias. Such arrhythmias result in diminished blood circulation. One mode of treating cardiac arrhythmias uses drug therapy. Drugs are often effective at restoring normal heart rhythms. However, drug therapy is not always effective for treating arrhythmias of certain patients. For such patients, an alternative mode of treatment is needed. One such alternative mode of treatment includes the use of a cardiac rhythm management system. Such systems are often implanted in the patient and deliver therapy to the heart.
[0005] Cardiac rhythm management systems include, among other things, pacemakers, also referred to as pacers. Pacers deliver timed sequences of low energy electrical stimuli, called pace pulses, to the heart, such as via an intravascular leadwire or catheter (referred to as a “lead”) having one or more electrodes disposed in or about the heart. Heart contractions are initiated in response to such pace pulses (this is referred to as “capturing” the heart). By properly timing the delivery of pace pulses, the heart can be induced to contract in proper rhythm, greatly improving its efficiency as a pump. Pacers are often used to treat patients with bradyarrhythmias, that is, hearts that beat too slowly, or irregularly.
[0006] Cardiac rhythm management systems also include cardioverters or defibrillators that are capable of delivering higher energy electrical stimuli to the heart. Defibrillators are often used to treat patients with tachyarrhythmias, that is, hearts that beat too quickly. Such too-fast heart rhythms also cause diminished blood circulation because the heart isn't allowed sufficient time to fill with blood before contracting to expel the blood. Such pumping by the heart is inefficient. A defibrillator is capable of delivering an high energy electrical stimulus that is sometimes referred to as a defibrillation countershock. The countershock interrupts the tachyarrhythmia, allowing the heart to reestablish a normal rhythm for the efficient pumping of blood. In addition to pacers, cardiac rhythm management systems also include, among other things, pacer/defibrillators that combine the functions of pacers and defibrillators, drug delivery devices, and any other implantable or external systems or devices for diagnosing or treating cardiac arrhythmias.
[0007] One problem faced by cardiac rhythm management systems is the proper treatment of ventricular arrhythmias that are caused by atrial tachyarrhythmias such as atrial fibrillation. Atrial fibrillation is a common cardiac arrhythmia which reduces the pumping efficiency of the heart, though not to as great a degree as in ventricular fibrillation. However, this reduced pumping efficiency requires the ventricle to work harder, which is particularly undesirable in sick patients that cannot tolerate additional stresses. As a result of atrial fibrillation, patients may be required to limit their activity and exercise.
[0008] Although atrial fibrillation, by itself, is usually not life-threatening, prolonged atrial fibrillation may be associated with strokes, which are thought to be caused by blood clots forming in areas of stagnant blood flow. Treating such blood clots requires the use of anticoagulants. Atrial fibrillation may also cause pain, dizziness, and other irritation to the patient.
[0009] An even more serious problem, however, is that atrial fibrillation may induce irregular ventricular heart rhythms by processes that are yet to be fully understood. Such induced ventricular arrhythmias compromise pumping efficiency even more drastically than atrial arrhythmias. For these and other reasons, there is a need for a method and apparatus for treating irregular ventricular contractions during atrial arrhythmias such as atrial fibrillation.
[0010] The present system provides a method and apparatus for treating irregular ventricular contractions, such as during atrial arrhythmias (e.g., atrial fibrillation), or otherwise. The present system provides many advantages. Among other things, it is capable of treating irregular ventricular heart contractions, such as during atrial tachyarrhythmias. It provides a first indicated pacing rate that increases for sensed ventricular beats and decreases for paced ventricular beats. The system delivers more pacing during irregular sensed beats (such as during atrial tachyarrhythmias including atrial fibrillation or the like) and less pacing when sensed beats are regular. In a stable heart, the first indicated pacing rate is typically less than the intrinsic heart rate. This avoids unnecessary pacing of the heart when heart rhythms are substantially stable, allowing the heart to beat normally and at its own intrinsic heart rate.
[0011] One aspect of the system permits it to avoid rapid changes in heart rate, and to keep heart rate within acceptable upper and lower limits. The system allows the rate to become more regular and to approach a stable rhythm. This provides improved comfort of the patient experiencing irregular ventricular contractions. In a further embodiment, the system includes a second indicated pacing rate, such as a sensor-indicated rate, and provides pacing therapy based on both the first and second indicated pacing rates. Other aspects of the invention will be apparent on reading the following detailed description of the invention and viewing the drawings that form a part thereof.
[0012] In one embodiment, the system obtains V-V intervals between ventricular beats. A first indicated pacing interval is computed based at least partially on a most recent V-V interval duration and a previous value of the first indicated pacing interval. Pacing therapy is provided based on the first indicated pacing interval.
[0013] In a further embodiment, the first indicated pacing interval is adjusted by an amount based at least on the most recent V-V interval duration and the previous value of the first indicated pacing interval, if the most recent V-V interval is concluded by an intrinsic beat. If, however, the most recent V-V interval is concluded by a paced beat, then the first indicated pacing interval is increased by an amount based at least on the most recent V-V interval duration and the previous value of the first indicated pacing interval.
[0014] In another embodiment, the system detects an atrial tachyarrhythmia. The system obtains V-V intervals between ventricular beats. A first indicated pacing interval is computed based at least partially on a most recent V-V interval duration and a previous value of the first indicated pacing interval. Pacing therapy is provided based on the first indicated pacing interval, if the atrial tachyarrhythmia is present.
[0015] One embodiment provides a cardiac rhythm management system that includes, among other things, a ventricular sensing circuit, a controller, and a ventricular therapy circuit. The controller includes a V-V interval timer, a first register, for storing information associated with a first indicated pacing interval, and a filter that updates the first indicated pacing interval based on the V-V interval timer and the information stored in the first register. Other aspects of the invention will be apparent on reading the following detailed description of the invention and viewing the drawings that form a part thereof.
[0016] In the drawings, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components.
[0017] FIG. 1 is a schematic drawing illustrating generally one embodiment of portions of a cardiac rhythm management system and an environment in which it is used.
[0018] FIG. 2 is a schematic drawing illustrating one embodiment of a cardiac rhythm management device coupled by leads to a heart.
[0019] FIG. 3 is a schematic diagram illustrating generally one embodiment of portions of a cardiac rhythm management device coupled to a heart.
[0020] FIG. 4 is a schematic diagram illustrating generally one embodiment of a controller.
[0021] FIG. 5 is a schematic diagram illustrating generally one conceptualization of portions of a controller.
[0022] FIG. 6 is a signal flow diagram illustrating generally one conceptual embodiment of operating a filter.
[0023] FIG. 7 is a signal flow diagram illustrating generally another conceptualization of operating the filter.
[0024] FIG. 8 is a signal flow diagram illustrating generally a further conceptualization of operating the filter.
[0025] FIG. 9 is a schematic diagram illustrating generally another conceptualization of portions of a controller.
[0026] FIG. 10 is a schematic diagram illustrating generally a further conceptualization of portions of a controller.
[0027] FIG. 11 is a graph illustrating generally one embodiment of operating a filter to provide a first indicated pacing rate, such as a VRR indicated rate, for successive ventricular heart beats.
[0028] FIG. 12 is a graph illustrating generally another embodiment of operating a filter to provide the first indicated pacing rate, such as a VRR indicated rate, and delivering therapy based on the first indicated pacing rate and based on a second indicated pacing rate, such as a sensor indicated rate.
[0029] FIG. 13 is a graph illustrating generally another illustrative example of heart rate vs. time according to a VRR algorithm spreadsheet simulation.
[0030] FIG. 14 is a graph illustrating generally one embodiment of using at least one of coefficients a and b as a function of heart rate (or a corresponding time interval).
[0031] In the following detailed description, reference is made to the accompanying drawings which form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention, and it is to be understood that the embodiments may be combined, or that other embodiments may be utilized and that structural, logical and electrical changes may be made without departing from the spirit and scope of the present invention. The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is defined by the appended claims and their equivalents. In the drawings, like numerals describe substantially similar components throughout the several views. Like numerals having different letter suffixes represent different instances of substantially similar components.
[0032] The present methods and apparatus will be described in applications involving implantable medical devices including, but not limited to, implantable cardiac rhythm management systems such as pacemakers, cardioverter/defibrillators, and pacer/defibrillators. However, it is understood that the present methods and apparatus may be employed in unimplanted devices, including, but not limited to, external pacemakers, cardioverter/defibrillators, pacer/defibrillators, monitors, programmers and recorders.
[0033] As stated earlier, one potential cause of irregularity of ventricular contractions arises during atrial tachyarrhythmias, such as atrial fibrillation. During atrial fibrillation, irregular ventricular contractions may be caused by a conducted atrial tachyarrhythmia, then pacing the ventricle will regularize the ventricular heart rate by establishing retrograde conduction from the ventricle. This, in turn, is believed to block forward conduction of atrial signals through the atrioventricular (A-V) node. As a result, irregular atrial signals do not trigger resulting irregular ventricular contractions.
[0034] One therapy for treating irregular ventricular contractions during atrial fibrillation is to increase the ventricular heart rate by pacing the ventricle at a higher rate than the unpaced (intrinsic) ventricular heart rate. Such therapy is believed to decrease the discomfort experienced by the patient having atrial arrhythmia because it regulates the ventricular contractions to avoid short periods between contractions and/or long periods without a contraction. Such therapy is also believed to decrease the ability of the atrial fibrillation to induce irregular ventricular contractions.
[0035] An increase in rate of ventricular contractions, however, must be done carefully to avoid pacing the heart at an unnecessarily high rate. Furthermore, such a therapy should not impose pacing where normal or “intrinsic” heart pacing is adequate such as, for example, when atrial tachyarrhythmias no longer cause disorder of ventricular contractions. As long as the heart is actively paced, it may be difficult or impossible to determine when to cease such a therapy. One advantage of the present system is that it allows intrinsic ventricular rhythms, if such rhythms are regular, but provides pacing that stabilizes ventricular rhythms if they become irregular, as discussed below.
[0036] This document describes, among other things, a cardiac rhythm management system providing a method and apparatus for treating irregular ventricular contractions during atrial arrhythmia. FIG. 1 is a schematic drawing illustrating, by way of example, but not by way of limitation, one embodiment of portions of a cardiac rhythm management system 100 and an environment in which it is used. In FIG. 1, system 100 includes an implantable cardiac rhythm management device 105, also referred to as an electronics unit, which is coupled by an intravascular endocardial lead 110, or other lead, to a heart 115 of patient 120. System 100 also includes an external programmer 125 providing wireless communication with device 105 using a telemetry device 130. Catheter lead 110 includes a proximal end 135, which is coupled to device 105, and a distal end 140, which is coupled to one or more portions of heart 115.
[0037] FIG. 2 is a schematic drawing illustrating, by way of example, but not by way of limitation, one embodiment of device 105 coupled by leads 110A-B to heart 115, which includes a right atrium 200A, a left atrium 200B, a right ventricle 205A, a left ventricle 205B, and a coronary sinus 220 extending from right atrium 200A. In this embodiment, atrial lead 110A includes electrodes (electrical contacts) disposed in, around, or near an atrium 200 of heart 115, such as ring electrode 225 and tip electrode 230, for sensing signals and/or delivering pacing therapy to the atrium 200. Lead 110A optionally also includes additional electrodes, such as for delivering atrial and/or ventricular cardioversion/defibrillation and/or pacing therapy to heart 115.
[0038] In FIG. 2, a ventricular lead 110B includes one or more electrodes, such as tip electrode 235 and ring electrode 240, for delivering sensing signals and/or delivering pacing therapy. Lead 110B optionally also includes additional electrodes, such as for delivering atrial and/or ventricular cardioversion/defibrillation and/or pacing therapy to heart 115. Device 105 includes components that are enclosed in a hermetically-sealed can 250. Additional electrodes may be located on the can 250, or on an insulating header 255, or on other portions of device 105, for providing unipolar pacing and/or defibrillation energy in conjunction with the electrodes disposed on or around heart 115. Other forms of electrodes include meshes and patches which may be applied to portions of heart 115 or which may be implanted in other areas of the body to help “steer” electrical currents produced by device 105. The present method and apparatus will work in a variety of configurations and with a variety of electrical contacts or “electrodes.”
[0039] FIG. 3 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, one embodiment of portions of device 105, which is coupled to heart 115. Device 105 includes a power source 300, an atrial sensing circuit 305, a ventricular sensing circuit 310, a ventricular therapy circuit 320, and a controller 325.
[0040] Atrial sensing circuit 305 is coupled by atrial lead 110A to heart 115 for receiving, sensing, and/or detecting electrical atrial heart signals. Such atrial heart signals include atrial activations (also referred to as atrial depolarizations or P-waves), which correspond to atrial contractions. Such atrial heart signals include normal atrial rhythms, and abnormal atrial rhythms including atrial tachyarrhythmias, such as atrial fibrillation, and other atrial activity. Atrial sensing circuit 305 provides one or more signals to controller 325, via node/bus 327, based on the received atrial heart signals. Such signals provided to controller 325 indicate, among other things, the presence of atrial fibrillation.
[0041] Ventricular sensing circuit 310 is coupled by ventricular lead 110B to heart 115 for receiving, sensing, and/or detecting electrical ventricular heart signals, such as ventricular activations (also referred to as ventricular depolarizations or R-waves), which correspond to ventricular contractions. Such ventricular heart signals include normal ventricular rhythms, and abnormal ventricular rhythms, including ventricular tachyarrhythmias, such as ventricular fibrillation, and other ventricular activity, such as irregular ventricular contractions resulting from conducted signals from atrial fibrillation. Ventricular sensing circuit 310 provides one or more signals to controller 325, via node/bus 327, based on the received ventricular heart signals. Such signals provided to controller 325 indicate, among other things, the presence of ventricular depolarizations, whether regular or irregular in rhythm.
[0042] Ventricular therapy circuit 320 provides ventricular pacing therapy, as appropriate, to electrodes located at or near one of the ventricles 205 of heart 115 for obtaining resulting evoked ventricular depolarizations. In one embodiment, ventricular therapy circuit 320 also provides cardioversion/defibrillation therapy, as appropriate, to electrodes located at or near one of the ventricles 205 of heart 115, for terminating ventricular fibrillation and/or other ventricular tachyarrhythmias.
[0043] Controller 325 controls the delivery of therapy by ventricular therapy circuit 320 and/or other circuits, based on heart activity signals received from atrial sensing circuit 305 and ventricular sensing circuit 310, as discussed below. Controller 325 includes various modules, which are implemented either in hardware or as one or more sequences of steps carried out on a microprocessor or other controller. Such modules are illustrated separately for conceptual clarity; it is understood that the various modules of controller 325 need not be separately embodied, but may be combined and/or otherwise implemented, such as in software/firmware.
[0044] In general terms, sensing circuits 305 and 310 sense electrical signals from heart tissue in contact with the catheter leads 110A-B to which these sensing circuits 305 and 310 are coupled. Sensing circuits 305 and 310 and/or controller 325 process these sensed signals. Based on these sensed signals, controller 325 issues control signals to therapy circuits, such as ventricular therapy circuit 320, if necessary, for the delivery of electrical energy (e.g., pacing and/or defibrillation pulses) to the appropriate electrodes of leads 110A-B. Controller 325 may include a microprocessor or other controller for execution of software and/or firmware instructions. The software of controller 325 may be modified (e.g., by remote external programmer 105) to provide different parameters, modes, and/or functions for the implantable device 105 or to adapt or improve performance of device 105.
[0045] In one further embodiment, one or more sensors, such as sensor 330, may serve as inputs to controller 325 for adjusting the rate at which pacing or other therapy is delivered to heart 115. One such sensor 330 includes an accelerometer that provides an input to controller 325 indicating increases and decreases in physical activity, for which controller 325 increases and decreases pacing rate, respectively. Another such sensor includes an impedance measurement, obtained from body electrodes, which provides an indication of increases and decreases in the patient's respiration, for example, for which controller 325 increases and decreases pacing rate, respectively. Any other sensor 330 providing an indicated pacing rate can be used.
[0046] FIG. 4 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, one embodiment of controller 325 that includes several different inputs to modify the rate at which pacing or other therapy is delivered. For example, Input #1 may provide information about left ventricular rate, Input #2 may provide an accelerometer-based indication of activity, and Input #3 may provide an impedance-based indication of respiration, such as minute ventilation. Based on at least one of these and/or other inputs, controller 325 provides an output indication of pacing rate as a control signal delivered to a therapy circuit, such as to ventricular therapy circuit 320. Ventricular therapy circuit 320 issues pacing pulses based on one or more such control signals received from controller 325. Control of the pacing rate may be performed by controller 325, either alone or in combination with peripheral circuits or modules, using software, hardware, firmware, or any combination of the like. The software embodiments provide flexibility in how inputs are processed and may also provide the opportunity to remotely upgrade the device software while still implanted in the patient without having to perform surgery to remove and/or replace the device 105.
[0047] FIG. 5 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, one conceptualization of portions of controller 325. At least one signal from ventricular sensing circuit 310 is received by ventricular event module 500, which recognizes the occurrence of ventricular events included within the signal. Such events are also referred to as “beats,” “activations,” “depolarizations,” “QRS complexes,” “R-waves,” “contractions.” Ventricular event module 500 detects intrinsic events (also referred to as sensed events) from the signal obtained from ventricular sensing circuit 310. Ventricular event module 500 also detects evoked events (resulting from a pace) either from the signal obtained from ventricular sensing circuit 310, or preferably from a ventricular pacing control signal obtained from pacing control module 505, which also triggers the delivery of a pacing stimulus by ventricular therapy circuit 320. Thus, ventricular events include both intrinsic/sensed events and evoked/paced events.
[0048] A time interval between successive ventricular events, referred to as a V-V interval, is recorded by a first timer, such as V-V interval timer 510. A filter 515 computes a “first indicated pacing interval,” i.e., one indication of a desired time interval between ventricular events or, stated differently, a desired ventricular heart rate. The first indicated pacing interval is also referred to as a ventricular rate regularization (VRR) indicated pacing interval. In various embodiments, filter 515 includes an averager, a weighted averager, a median filter, an infinite (IIR) filter, a finite impulse response (FIR) filter, or any other analog or digital signal processing circuit providing the desired signal processing described more particularly below.
[0049] In one embodiment, filter 515 computes a new value of the first indicated pacing interval based on the duration of the most recent V-V interval recorded by timer 510 and on a previous value of the first indicated pacing interval stored in first indicated pacing interval register 520. Register 520 is then updated by storing the newly computed first indicated pacing interval in register 520. Based on the first indicated pacing interval stored in register 520, pacing control module 505 delivers control signals to ventricular therapy circuit 320 for delivering therapy, such as pacing stimuli, at the VRR-indicated ventricular heart rate corresponding to the inverse of the duration of the first indicated pacing interval.
[0050] In general terms, for one embodiment, device 105 obtains V-V intervals between successive sensed or evoked ventricular beats. Device 105 computes a new first indicated pacing interval based at least in part on the duration of the most recent V-V interval and a previous value of the first indicated pacing interval. Device 105 provides pacing therapy delivered at a rate corresponding to the inverse of the duration of the first indicated pacing interval.
[0051] FIG. 6 is a signal flow diagram illustrating generally, by way of example, but not by way of limitation, one embodiment of operating filter 515. Upon the occurrence of a sensed or evoked ventricular beat, timer 510 provides filter 515 with the duration of the V-V interval concluded by that beat, which is referred to as the most recent V-V interval (VVn). Filter 515 also receives the previous value of the first indicated pacing interval (Tn-1) stored in register 520. The most recent V-V interval VVn and the previous value of the first indicated pacing interval Tn-1 are each scaled by respective constants A and B, and then summed to obtain a new value of the first indicated pacing interval (Tn), which is stored in register 520 and provided to pacing control module 505. In one embodiment, the coefficients A and B are different values, and are either programmable, variable, or constant.
[0052] If no ventricular beat is sensed during the new first indicated pacing interval Tn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the new first indicated pacing interval Tn. In one embodiment, operation of the filter is described by Tn=A·VVn+B·Tn-1, where A and B are coefficients (also referred to as “weights”), VVn is the most recent V-V interval duration, and Tn-1 is the previous value of the first indicated pacing interval.
[0053] Initialization of filter 515 includes seeding the filter by storing, in register 520, an initial interval value. In one embodiment, register 520 is initialized to an interval value corresponding to a lower rate limit (LRL), i.e., a minimum rate at which pacing pulses are delivered by device 105. Register 520 could alternatively be initialized with any other suitable value.
[0054] In one embodiment, operation of filter 515 is based on whether the beat concluding the most recent V-V interval VVn is a sensed/intrinsic beat or a paced/evoked beat. In this embodiment, the pacing control module 505, which controls the timing and delivery of pacing pulses, provides an input to filter 515 that indicates whether the most recent V-V interval VVn was concluded by an evoked beat initiated by a pacing stimulus delivered by device 105, or was concluded by an intrinsic beat sensed by ventricular sensing circuit 310.
[0055] In general terms, if the most recent V-V interval VVn is concluded by a sensed/intrinsic beat, then filter 515 provides a new first indicated pacing interval Tn that is adjusted from the value of the previous first indicated pacing interval Tn-1 such as, for example, decreased by an amount that is based at least partially on the duration of the most recent V-V interval VVn and on the duration of the previous value of the first indicated pacing interval Tn-1. If, however, the most recent V-V interval VVn is concluded by a paced/evoked beat, then filter 515 provides a new first indicated pacing interval Tn that is increased from the value of the previous first indicated pacing interval Tn-1, such as, for example, by an amount that is based at least partially on the duration of the most recent V-V interval VVn and on the duration of the previous value of the first indicated pacing interval Tn-1. If no ventricular beat is sensed during the new first indicated pacing interval Tn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the new first indicated pacing interval Tn.
[0056] FIG. 7 is a signal flow diagram, illustrating generally, by way of example, but not by way of limitation, another conceptualization of operating filter 515, with certain differences from FIG. 6 more particularly described below. In this embodiment, the pacing control module 505, which controls the timing and delivery of pacing pulses, provides an input to filter 515 that indicates whether the most recent V-V interval VVn was concluded by an evoked beat initiated by a pacing stimulus delivered by device 105, or was concluded by an intrinsic beat sensed by ventricular sensing circuit 310.
[0057] If the most recent V-V interval VVn was concluded by an intrinsic beat, then the most recent V-V interval VVn and the previous value of the first indicated pacing interval Tn-1 are each scaled by respective constants A and B, and then summed to obtain the new value of the first indicated pacing interval Tn, which is stored in register 520 and provided to pacing control module 505. Alternatively, if the most recent V-V interval VVn was concluded by a evoked/paced beat, then the most recent V-V interval VVn and the previous value of the first indicated pacing interval Tn-1 are each scaled by respective constants C and D, and then summed to obtain the new value of the first indicated pacing interval Tn, which is stored in register 520 and provided to pacing control module 505. In one embodiment, the coefficients C and D are different from each other, and are either programmable, variable, or constant. In a further embodiment, the coefficient C is a different value from the coefficient A, and/or the coefficient D is a different value than the coefficient B, and these coefficients are either programmable, variable, or constant. In another embodiment, the coefficient D is the same value as the coefficient B.
[0058] In one embodiment, operation of filter 515 is described by Tn=A·VVn+B·Tn-1, if VVn is concluded by an intrinsic beat, and is described by Tn=C·VVn+D·Tn-1, if VVn is concluded by a paced beat, where A, B, C and D are coefficients (also referred to as “weights”), VVn is the most recent V-V interval duration, Tn is the new value of the first indicated pacing interval, and Tn-1 is the previous value of the first indicated pacing interval. If no ventricular beat is sensed during the new first indicated pacing interval Tn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the new first indicated pacing interval Tn.
[0059] In another embodiment, these coefficients can be more particularly described using an intrinsic coefficient (a), a paced coefficient (b), and a weighting coefficient (w). In one such embodiment, A=a·w, B=(1−w), C=b·w, and D=(1−w). In one example, operation of the filter 515 is described by Tn=a·w·VVn+(1−w)·Tn-1, if VVn is concluded by an intrinsic beat, otherwise is described by Tn=b·w·VVn+(1−w)·Tn-1, if VVn is concluded by a paced beat, as illustrated generally, by way of example, but not by way of limitation, in the signal flow graph of FIG. 8. If no ventricular beat is sensed during the new first indicated pacing interval Tn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the new first indicated pacing interval Tn. In one embodiment, the coefficients a and b are different from each other, and are either programmable, variable, or constant.
[0060] The above-described parameters (e.g., A, B, C, D, a, b, w) are stated in terms of time intervals (e.g., VVn, Tn, Tn-1). However, an alternate system may produce results in terms of rate, rather than time intervals, without departing from the present method and apparatus. In one embodiment, weighting coefficient w, intrinsic coefficient a, and paced coefficient b, are variables. Different selections of w, a, and b, will result in different operation of the present method and apparatus. For example, as w increases the weighting effect of the most recent V-V interval VVn increases and the weighting effect of the previous first indicated pacing rate Tn-1 decreases. In one embodiment, w= 1/16=0.0625. In another embodiment, w= 1/32. Another possible range for w is from w=½ to w= 1/1024. A further possible range for w is from w≈0 to w≈1. Other values of w, which need not include division by powers of two, may be substituted without departing from the present method and apparatus.
[0061] In one embodiment, intrinsic coefficient a, is selected to be greater than 0.5, or to be greater than 1.0. In one example, the intrinsic coefficient a is selected to be lesser in value than the pacing coefficient b. In one example, a≈1.1 and b≈1.2. In another embodiment a=0.9 and b=1.1. One possible range for a is from a=0.5 to a=2.0, and for b is from b=1.0 to b=3.0. The coefficients may vary without departing from the present method and apparatus.
[0062] In one embodiment, for b>1 and for substantially regular V-V intervals, filter 515 provides a new first indicated pacing interval Tn that is at least slightly longer than the expected intrinsic V-V interval being measured by timer 515. Thus, if the intrinsic V-V interval being timed is consistent with the duration of previously received V-V intervals, then filter 515 avoids triggering a pacing stimulus. In such a case, a pacing pulse is delivered only if the presently timed V-V interval becomes longer than the previous substantially constant V-V intervals. In general terms, filter 515 operates so that pacing pulses are typically inhibited if the ventricular rate is substantially constant. However, if the measured V-V intervals become irregular, then filter 515 operates, over a period of one or several such V-V intervals, to shorten the first indicated pacing interval Tn so that pacing stimuli are being delivered.
[0063] According to one aspect of the invention, it is believed that if the irregular V-V intervals are caused by a conducted atrial tachyarrhythmia, then pacing the ventricle will regularize the ventricular heart rate by establishing retrograde conduction from the ventricle. This, in turn, blocks forward conduction of atrial signals through the atrioventricular (A-V) node. As a result, irregular atrial signals do not trigger resulting irregular ventricular contractions. According to another aspect of the invention, however, this method and apparatus will not introduce pacing pulses until the heartbeat becomes irregular. Therefore, the heart is assured to pace at its intrinsic rate when regular ventricular contractions are sensed.
[0064] FIG. 9 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, another conceptualization of portions of controller 325, with certain differences from FIG. 5 more particularly described below. In FIG. 9, controller 325 receives from sensor 330 a signal including information from which a physiologically desired heart rate (e.g., based on the patient's activity, respiration, or any other suitable indicator of metabolic need) can be derived. The sensor signal is digitized by an A/D converter 900. The digitized signal is processed by a sensor rate module 905, which computes a desired heart rate that is expressed in terms of a second indicated pacing interval stored in register 910.
[0065] Pacing control module 505 delivers a control signal, which directs ventricular therapy circuit 320 to deliver a pacing pulse, based on either (or both) of the first or second indicated pacing intervals, stored in registers 520 and 910, respectively, or both. In one embodiment, pacing control module 505 includes a selection module 915 that selects between the new first indicated pacing interval Tn and the sensor-based second indicated pacing interval.
[0066] In one embodiment, selection module 915 selects the shorter of the first and second indicated pacing intervals as the selected indicated pacing interval Sn. If no ventricular beat is sensed during the selected indicated pacing interval Sn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the selected indicated pacing interval Sn.
[0067] In general terms, for this embodiment, the ventricle is paced at the higher of the sensor indicated rate and the VRR indicated rate. If, for example, the patient is resting, such that the sensor indicated rate is lower than the patient's intrinsic rate, and the patient's intrinsic rate is substantially constant, then the intrinsic rate is higher than the VRR indicated rate. As a result, pacing pulses generally will not be delivered. But if, for example, the patient is resting, but with an atrial tachyarrhythmia that induces irregular ventricular contractions, then pacing pulses generally will be delivered at the VRR indicated rate. In another example, if the patient is active, such that the sensor indicated rate is higher than the VRR indicated rate, then pacing pulses generally will be delivered at the sensor indicated rate. In an alternative embodiment, the pacing rate is determined by blending the sensor indicated rate and the VRR indicated rate, rather than by selecting the higher of these two indicated rates (i.e., the shorter of the first and second indicated pacing intervals).
[0068] In another embodiment, selection module 915 provides a selected indicated pacing interval Sn based on a blending of both the first and second indicated pacing intervals. In one such example, selection module 915 applies predetermined or other weights to the first and second indicated pacing intervals to compute the selected pacing interval Sn.
[0069] FIG. 10 is a schematic diagram illustrating generally, by way of example, but not by way of limitation, another conceptualization of portions of controller 325, with certain differences from FIG. 9 more particularly described below. In FIG. 10, controller 325 includes an atrial tachyarrhythmia (AT) detection module 1000 that receives a signal from atrial sensing circuit 305. The received signal includes information about atrial events, from which AT detection module 1000 determines the presence or absence of one or more atrial tachyarrhythmias, such as atrial fibrillation.
[0070] In one embodiment, AT detection module 1000 provides a control signal, to pacing control module 505, that indicates the presence or absence of an atrial tachyarrhythmia, such as atrial fibrillation. In one embodiment, selection module 915 selects between the first and second indicated pacing intervals as illustrated, by way of example, but not by way of limitation, in Table 1.
[0071] In this embodiment, if an atrial tachyarrhythmia is present and the first indicated pacing interval is shorter than the second indicated pacing interval, then selection module 915 selects the first indicated pacing interval, which is based on the VRR techniques described above, as the selected indicated pacing interval Sn. Otherwise, selection module 915 selects the second indicated pacing interval, which in one embodiment is based on the sensor indications, as the selected indicated pacing interval Sn. As discussed above, if no ventricular beat is sensed during the selected indicated pacing interval Sn, which is measured as the time from the occurrence of the ventricular beat concluding the most recent V-V interval VVn, then pacing control module 505 instructs ventricular therapy circuit 320 to deliver a ventricular pacing pulse upon the expiration of the selected indicated pacing interval Sn.
[0072] Stated differently, for this embodiment, the ventricle is paced at the VRR indicated rate only if an atrial tachyarrhythmia, such as atrial fibrillation, is present and the VRR indicated rate exceeds the sensor indicated rate. Otherwise the ventricle is paced at the sensor indicated rate. If, for example, the patient is resting, such that the sensor indicated rate is lower than the patient's intrinsic rate, and no atrial tachyarrhythmia is present, then the device will sense the intrinsic rate or will deliver ventricular paces at the lower rate limit. But if, for example, the patient is resting, but with an atrial tachyarrhythmia that induces irregular ventricular contractions, then pacing pulses generally will be delivered at the VRR indicated rate. In another example, if the patient is active, such that the sensor indicated rate is higher than the VRR indicated rate, then pacing pulses generally will be delivered at the sensor indicated rate, whether or not atrial tachyarrhythmia is present. As an alternative to the selection described with respect to Table 1, selection module 915 provides a fixed or variable weighting or blending of both the sensor-indicated rate and VRR indicated rate, such that pacing pulses are delivered based on the blended rate.
[0073] The second indicated pacing interval need not be based on sensor indications. In one embodiment, for example, the second indicated pacing interval tracks the sensed atrial heart rate when no atrial tachyarrhythmia is present. In this embodiment, selection module 915 performs a mode-switching function in which the first indicated pacing interval is used whenever atrial tachyarrhythmia is present and the second indicated pacing interval (e.g., atrial-tracking) is used when no atrial tachyarrhythmia is present.
[0074] In another embodiment, heart rate/interval is used as a trigger turn on/off use of the first indicated pacing interval (e.g., the VRR indicated pacing interval). In one example, pacing therapy is based on the first indicated pacing interval if the first indicated pacing interval is longer than a first predetermined value, and pacing therapy is substantially independent of the first indicated pacing interval if the first indicated pacing interval is shorter than the first predetermined value. In this example, the VRR indicated pacing interval is used at low heart rates, but not at fast heart rates.
[0075] FIG. 11 is a graph illustrating generally, by way of example, but not by way of limitation, one embodiment of a VRR indicated rate for successive ventricular heart beats for one mode of operating filter 515. As discussed above, the VRR indicated rate is simply the frequency, between ventricular heart beats, associated with the first indicated pacing interval. Stated differently, the VRR indicated rate is the inverse of the duration of the first indicated pacing interval. If pacing is based solely on the VRR indicated rate, pacing control module 505 directs ventricular therapy circuit 320 to issue a pacing pulse after the time since the last ventricular beat equals or exceeds the first indicated pacing interval. However, as described above, in certain embodiments, pacing control module 505 directs ventricular therapy circuit 320 to issue a pacing pulse based on factors other than the VRR indicated rate such as for, example, based on the sensor indicated rate.
[0076] In the example illustrated in FIG. 11, a first sensed intrinsic ventricular beat, indicated by an “S” was detected just before expiration of the first indicated pacing interval (“VRR indicated pacing interval”) T0, as computed based on a previous ventricular beat. In one embodiment, the new VRR indicated pacing interval T1 is computed based on the duration of most recent V-V interval VV1 and a previous value of the VRR indicated pacing interval T0, as discussed above. In this example, the new VRR indicated pacing interval T1 corresponds to a lower rate limit (LRL) time interval. In one embodiment, the allowable range of the VRR indicated pacing interval is limited so that the VRR indicated pacing interval does not exceed the duration of the LRL time interval, and so that the VRR indicated pacing interval is not shorter than the duration of an upper rate limit (URL) time interval.
[0077] The second ventricular beat is also sensed, just before expiration of the VRR indicated pacing interval T1. In one embodiment, the new VRR indicated pacing interval T2 is computed based on the duration of most recent V-V interval VV2 and a previous value of the VRR indicated pacing interval, T1, as discussed above. The first and second ventricular beats represent a stable intrinsic rhythm, for which no pacing is delivered because the VRR indicated pacing interval is at a lower rate than the sensed intrinsic ventricular beats.
[0078] The third, fourth, and fifth ventricular beats represent the onset of atrial fibrillation, resulting in erratic ventricular rates. The third ventricular beat is sensed well before expiration of the VRR indicated pacing interval T2, such that no pacing pulse is issued. For the sensed third ventricular beat, filter 515 computes the new VRR indicated pacing interval T3 as being shorter in duration relative to the previous VRR indicated pacing interval T2.
[0079] The fourth ventricular beat is similarly sensed well before expiration of the VRR indicated pacing interval T3, such that no pacing pulse is issued. For the sensed fourth ventricular beat, filter 515 computes the new VRR indicated pacing interval T4 as being shorter in duration relative to the previous VRR indicated pacing interval T3.
[0080] The fifth ventricular beat is sensed before expiration of the VRR indicated pacing interval T4, such that no pacing pulse is issued. For the sensed fifth ventricular beat, filter 515 computes the new VRR indicated pacing interval T5 as being shorter in duration relative to the previous VRR indicated pacing interval T4.
[0081] The sixth, seventh, and eighth ventricular beats indicate regularization of the ventricular rate using the pacing techniques described above. No ventricular beat is sensed during the VRR indicated pacing interval T5, so a pacing pulse is issued to evoke the sixth ventricular beat. A new VRR indicated pacing interval T6 is computed as being increased in duration relative to the previous VRR indicated pacing interval T5, lowering the VRR indicated rate. Similarly, no ventricular beat is sensed during the VRR indicated pacing interval.
[0082] The ninth ventricular beat represents another erratic ventricular beat resulting from the atrial fibrillation episode. The ninth ventricular beat is sensed before expiration of the VRR indicated pacing interval T8. As a result, a shorter new VRR indicated pacing interval T9 is computed.
[0083] The tenth and eleventh ventricular beats illustrate further regularization of the ventricular rate using the pacing techniques described above. No ventricular beat is sensed during the VRR indicated pacing interval T9, so a pacing pulse is issued to evoke the tenth ventricular beat. A new VRR indicated pacing interval T10 is computed as being increased in duration relative to the previous VRR indicated pacing interval T9, lowering the VRR indicated rate. Similarly, no ventricular beat is sensed during the VRR indicated pacing interval T10, so a pacing pulse is issued to evoke the tenth ventricular beat. A new VRR indicated pacing interval T11 is compute as being increased in duration relative to the previous VRR indicated pacing interval T10, lowering the VRR indicated rate.
[0084] The twelfth, thirteenth, fourteenth, and fifteenth ventricular beats illustrate resumption of a stable intrinsic rhythm after termination of the atrial fibrillation episode. For such a stable rate, the VRR indicated rate proceeds asymptotically toward a “floor value” that tracks, but remains below, the intrinsic rate. This allows the intrinsic heart signals to control heart rate when such intrinsic heart signals provide a stable rhythm. As a result, when the patient's intrinsic rate is constant, paces will be withheld, allowing the patient's intrinsic heart rhythm to continue. If the patient's heart rate includes some variability, and the VRR indicated floor value is close to the mean intrinsic heart rate, then occasional paced beats will occur. Such pace beats will gradually lengthen the VRR indicated pacing interval, thereby allowing subsequent intrinsic behavior when the patient's heart rate becomes substantially constant.
[0085] The intrinsic coefficient a of filter 515 controls the “attack slope” of the VRR indicated heart rate as the VRR indicated heart rate increases because of sensed intrinsic beats. The paced coefficient b of filter 515 controls the “decay slope” of the VRR indicated heart rate as the VRR indicated heart rate decreases during periods of paced beats. In one embodiment, in which a>1.0 and b>1.0, decreasing the value of a toward 1.0 increases the attack slope such that the VRR indicated rate increases faster in response to sensed intrinsic beats, while decreasing the value of b toward 1.0 decreases the decay slope such that the VRR indicated rate decreases more slowly during periods of paced beats. Conversely, for a>1.0 and b>1.0, increasing the value of a from 1.0 decreases the attack slope such that the VRR indicated rate increases more slowly in response to sensed intrinsic beats, while increasing the value of b from 1.0 increases the decay slope such that the VRR-indicated rate decreases more quickly during periods of paced beats.
[0086] In one embodiment, for a>1.0 and b>1.0, decreasing both a and b toward 1.0 increases VRR indicated rate during periods of sensed intrinsic activity so that the VRR indicated rate is closer to the mean intrinsic rate. Because the VRR indicated rate is closer to the mean intrinsic rate, variability in the intrinsic heart rate is more likely to trigger paces at the VRR indicated rate. On the other hand, for a>1.0 and b>1.0, increasing both a and b from 1.0 decreases the VRR indicated rate during periods of sensed intrinsic activity so that the VRR indicated rate is farther beneath the mean intrinsic rate. Because the VRR indicated rate is farther beneath the mean intrinsic rate, the same variability in the intrinsic heart rate becomes less likely to trigger paces at the VRR indicated rate.
[0087] In one embodiment, these coefficients are programmable by the user, such as by using remote programmer 125. In another embodiment, the user selects a desired performance parameter (e.g., desired degree of rate regularization, desired attack slope, desired decay slope, etc.) from a corresponding range of possible values, and device 105 automatically selects the appropriate combination of coefficients of filter 515 to provide a filter setting that corresponds to the selected user-programmed performance parameter, as illustrated generally by Table 2. Other levels of programmability or different combinations of coefficients may also be used.
[0088] FIG. 12 is a graph illustrating generally, by way of example, but not by way of limitation, one embodiment of selecting between more than one indicated pacing interval. FIG. 12 is similar to FIG. 11 in some respects, but FIG. 12 includes a second indicated pacing interval. In one embodiment, the first indicated pacing interval is the VRR indicated pacing interval, described above, and the second indicated pacing interval is a sensor indicated pacing interval, from an accelerometer, minute ventilation, or other indication of the patient's physiological need for increased cardiac output.
[0089] In one embodiment, a selected indicated pacing interval is based on the shorter of the first and second indicated pacing intervals. Stated differently, device 105 provides pacing pulses at the higher indicated pacing rate. In the example illustrated in FIG. 12, first and second beats and the twelfth through fifteenth beats are paced at the sensor indicated rate, because it is higher than the VRR indicated rate and the intrinsic rate. The third, fourth, fifth, and ninth beats are sensed intrinsic beats that are sensed during the shorter of either of the VRR and sensor indicated pacing intervals. The sixth through eighth beats and tenth and eleventh beats are paced at the VRR indicated rate, because it is higher than the sensor indicated rate. Also, for these beats, no intrinsic beats are sensed during the VRR indicated intervals. In one embodiment, the above-described equations for filter 515 operate to increase the VRR indicated rate toward the sensor-indicated rate when the sensor indicated rate is greater than the VRR indicated rate, as illustrated by first through third and twelfth through fifteenth beats in FIG. 12. In an alternate embodiment, however, Tn=b·w·VVn+(1−w)·Tn-1, if VVn is concluded by a VRR indicated paced beat, and Tn=Tn-1 if VVn is concluded by a sensor indicated paced beat, thereby leaving the VRR indicated rate unchanged for sensor indicated paced beats.
[0090] In this embodiment, the ranges of both the sensor indicated rate and the VRR indicated rate are limited so that they do not extend to rates higher than the URL or to rates lower than the LRL. In one embodiment, the LRL and the URL are programmable by the user, such as by using remote programmer 125.
[0091] In a further embodiment, the selected indicated pacing interval is based on the shorter of the first and second indicated pacing intervals only if an atrial tachyarrhythmia, such as atrial fibrillation, is present. Otherwise, the second indicated pacing interval is used, as described above.
[0092] FIG. 13 is a graph illustrating generally, by way of example, but not by way of limitation, another illustrative example of heart rate vs. time according to a spreadsheet simulation of the behavior of the above-described VRR algorithm. In FIG. 13, the VRR algorithm is turned off until time 130. Stable intrinsic lower rate behavior is modeled for times between 0 and 10 seconds. Erratic intrinsic ventricular rates, such as would result from atrial tachyarrhythmias including atrial fibrillation, are modeled during times between 10 seconds and 130 seconds. At time 130 seconds, the VRR algorithm is turned on. While some erratic intrinsic beats are subsequently observed, the VRR algorithm provides pacing that is expected to substantially stabilize the heart rate, as illustrated in FIG. 13. The VRR indicated pacing rate gradually decreases until intrinsic beats are sensed, which results in a slight increase in the VRR indicated pacing rate. Thus, the VRR algorithm favors the patient's intrinsic heart rate when it is stable, and paces at the VRR indicated heart rate when the patient's intrinsic heart rate is unstable. It is noted that FIG. 13 does not represent clinical data, but rather provides a simulation model that illustrates one example of how the VRR algorithm is expected to operate.
[0093] In one embodiment, filter 515 includes variable coefficients such as, for example, coefficients that are a function of heart rate (or its corresponding time interval). In one example, operation of the filter 515 is described by Tn=a·w·VVn+(1−w)·Tn-1, if VVn is concluded by an intrinsic beat, otherwise is described by Tn=b·w·VVn+(1−w)·Tn-1, if VVn is concluded by a paced beat, where at least one of a and b are linear, piecewise linear, or nonlinear functions of one or more previous V-V intervals such as, for example, the most recent V-V interval, VVn.
[0094] FIG. 14 is a graph illustrating generally, by way of example, but not by way of limitation, one embodiment of using at least one of coefficients a and b as a function of one or more previous V-V intervals such as, for example, the most recent V-V interval VVn. In one such example, a is less than 1.0 when VVn is at or near the lower rate limit (e.g., 1000 millisecond interval or 60 beats/minute), and a is greater than 1.0 when VVn is at or near the upper rate limit (e.g., 500 millisecond interval or 120 beats/minute). For a constant b, using a smaller value of a at lower rates will increase the pacing rate more quickly for sensed events; using a larger value of a at higher rates increases the pacing rate more slowly for sensed events. In another example, b is close to 1.0 when VVn is at or near the lower rate limit, and b is greater than 1.0 when VVn is at or near the upper rate limit. For a constant a, using a smaller value of b at lower rates will decrease the pacing rate more slowly for paced events; using a larger value of b at higher rates decreases the pacing rate more quickly for paced events.
[0095] It is to be understood that the above description is intended to be illustrative, and not restrictive. Many other embodiments will be apparent to those of skill in the art upon reviewing the above description. The scope of the invention should, therefore, be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4085215 *Jul 30, 1975Apr 18, 1978John Wyeth & Brother Ltd.Certain 5,6,7,8-tetrahydroquinoline-8-thiocarboxamidesUS4432360 *Jul 6, 1981Feb 21, 1984Cordis CorporationInteractive programmer for biomedical implantable devicesUS4503857 *Oct 25, 1982Mar 12, 1985Vitatron Medical B.V.Programmable cardiac pacemaker with microprocessor control of pacer rateUS4562841 *Aug 5, 1982Jan 7, 1986Cardiac Pacemakers, Inc.Programmable multi-mode cardiac pacemakerUS4809697 *Oct 14, 1987Mar 7, 1989Siemens-Pacesetter, Inc.Interactive programming and diagnostic system for use with implantable pacemakerUS4890617 *Nov 25, 1987Jan 2, 1990Medtronic, Inc.Dual chamber activity responsive pacerUS4905697 *Feb 14, 1989Mar 6, 1990Cook Pacemaker CorporationTemperature-controlled cardiac pacemaker responsive to body motionUS4917115 *Jul 11, 1988Apr 17, 1990Vitatron Medical B. V.Pacing system and method for physiological stimulation of the heart utilizing Doppler meansUS4998974 *Jan 5, 1990Mar 12, 1991Telectronics Pacing Systems, Inc.Apparatus and method for antitachycardia pacing in dual chamber arrhythmia control systemUS5101824 *Apr 16, 1990Apr 7, 1992Siemens-Pacesetter, Inc.Rate-responsive pacemaker with circuitry for processing multiple sensor inputsUS5107850 *Nov 2, 1990Apr 28, 1992Cardiac Pacemakers, Inc.Method and apparatus for classifying and treating cardiac arrhythmias based on atrial and ventricular activityUS5179945 *Jan 17, 1991Jan 19, 1993Cardiac Pacemakers, Inc.Defibrillation/cardioversion system with multiple evaluation of heart condition prior to shock deliveryUS5179949 *Dec 7, 1990Jan 19, 1993Raul ChirifeCardiac pacemaker with automatic a-v programming for optimization of left heart a-v intervalUS5183040 *Mar 8, 1991Feb 2, 1993Telectronics Pacing Systems, Inc.Apparatus and method for detecting abnormal cardiac rhythms using an ultrasound sensor in an arrhythmia control systemUS5184614 *Oct 19, 1990Feb 9, 1993Telectronics Pacing Systems, Inc.Implantable haemodynamically responsive cardioverting/defibrillating pacemakerUS5188105 *Nov 14, 1990Feb 23, 1993Medtronic, Inc.Apparatus and method for treating a tachyarrhythmiaUS5188106 *Mar 8, 1991Feb 23, 1993Telectronics Pacing Systems, Inc.Method and apparatus for chronically monitoring the hemodynamic state of a patient using doppler ultrasoundUS5193535 *Aug 27, 1991Mar 16, 1993Medtronic, Inc.Method and apparatus for discrimination of ventricular tachycardia from ventricular fibrillation and for treatment thereofUS5193550 *Nov 30, 1990Mar 16, 1993Medtronic, Inc.Method and apparatus for discriminating among normal and pathological tachyarrhythmiasUS5197467 *Jun 22, 1992Mar 30, 1993Telectronics Pacing Systems, Inc.Multiple parameter rate-responsive cardiac stimulation apparatusUS5282836 *Oct 23, 1992Feb 1, 1994Incontrol, Inc.Atrial defibrillator and method for providing pre-cardioversion pacingUS5284491 *Feb 27, 1992Feb 8, 1994Medtronic, Inc.Cardiac pacemaker with hysteresis behaviorUS5292338 *Jul 30, 1992Mar 8, 1994Medtronic, Inc.Atrial defibrillator employing transvenous and subcutaneous electrodes and method of useUS5292339 *Apr 29, 1992Mar 8, 1994Telectronics Pacing Systems, Inc.Implantable pacemaker/cardioverter/defibrillator device and method incorporating multiple bradycardia support pacing ratesUS5292341 *Mar 2, 1992Mar 8, 1994Siemens Pacesetter, Inc.Method and system for determining and automatically adjusting the sensor parameters of a rate-responsive pacemakerUS5379776 *Dec 1, 1993Jan 10, 1995Telectronics Pacing Systems, Inc.Heart rhythm classification method, and implantable dual chamber cardioverter/defibrillator employing the sameUS5383910 *Feb 19, 1993Jan 24, 1995Medtronic, Inc.Method and apparatus for tachyarrhythmia detection and treatmentUS5387229 *Jan 21, 1993Feb 7, 1995Pacesetter, Inc.Multi-sensor cardiac pacemaker with sensor event recording capabilityUS5391189 *Nov 4, 1993Feb 21, 1995Vitatron Medical, B.V.Rate adaptive dual chamber pacing system and method with automatic adjustment of operating parameters for minimizing sensor-sinus competitionUS5395373 *Jan 7, 1993Mar 7, 1995Incontrol, Inc.Atrial defibrillator and method for setting energy threshold valuesUS5395397 *Sep 9, 1993Mar 7, 1995Siemens Elema AbMethod and apparatus for stimulating a heartUS5400796 *Oct 22, 1993Mar 28, 1995Siemens-Elema AbDevice for identifying atrial depolarizationUS5480413 *Nov 30, 1994Jan 2, 1996Telectronics Pacing Systems, Inc.Apparatus and method for stabilizing the ventricular rate of a heart during atrial fibrillationUS5486198 *Aug 12, 1994Jan 23, 1996Ayers; Gregory M.Atrial defibrillator and method for providing interval timing of successive intervals prior to cardioversionUS5487752 *Nov 15, 1994Jan 30, 1996Cardiac Pacemakers, Inc.Automated programmable stimulating device to optimize pacing parameters and methodUS5489293 *Mar 31, 1994Feb 6, 1996Ventritex, Inc.Method and apparatus for treating cardiac tachyarrhythmiaUS5507782 *Mar 17, 1994Apr 16, 1996Medtronic, Inc.Method and apparatus for dual chamber cardiac pacingUS5507784 *Apr 6, 1995Apr 16, 1996Medtronic, Inc.Method and apparatus for control of A-V intervalUS5591215 *Nov 17, 1995Jan 7, 1997Telectronics Pacing Systems, Inc.Apparatus and method for detection of atrial fibrillation by ventricular stability and ventricular pacingUS5605159 *Feb 16, 1996Feb 25, 1997Smith; Joseph M.System and method for determining spatial organization of atrial activationUS5607460 *Mar 15, 1996Mar 4, 1997Angeion CorporationPhysician interface expert system for programming implantable arrythmia treatment devicesUS5613495 *Jul 6, 1995Mar 25, 1997Instromedix, Inc.High functional density cardiac monitoring system for captured windowed ECG dataUS5620471 *Jun 16, 1995Apr 15, 1997Pacesetter, Inc.System and method for discriminating between atrial and ventricular arrhythmias and for applying cardiac therapy thereforUS5620473 *Mar 8, 1995Apr 15, 1997Pacesetter, Inc.Calibration system for pacemaker-generated intracardiac electrogramUS5622178 *May 4, 1994Apr 22, 1997Spacelabs Medical, Inc.System and method for dynamically displaying cardiac interval data using scatter-plotsUS5713928 *Jul 25, 1996Feb 3, 1998Ela MedicalProcess of controlling a dual chamber cardiac pacemakerUS5713929 *May 3, 1996Feb 3, 1998Medtronic, Inc.Arrhythmia and fibrillation prevention pacemaker using ratchet up and decay modes of operationUS5713930 *Nov 6, 1996Feb 3, 1998Vitatron Medical, B.V.Dual chamber pacing system and method with control of AV intervalUS5713932 *Oct 28, 1996Feb 3, 1998Medtronic, Inc.Method and apparatus for determining atrial lead disclocation and confirming diagnosis of atrial tachyarrhythimiasUS5716382 *Aug 2, 1995Feb 10, 1998Pacesetter, Inc.Programmer for an implantable cardiac stimulating deviceUS5716383 *Jun 24, 1996Feb 10, 1998Medtronic, Inc.Dual chamber pacing system and method with continual adjustment of the AV escape interval so as to maintain optimized ventricular pacing for treating cardiomyopathyUS5716384 *Jul 8, 1996Feb 10, 1998Pacesetter, Inc.Method and system for organizing, viewing and manipulating information in implantable device programmerUS5718235 *Jul 30, 1996Feb 17, 1998Gw Scientific, Inc.Detection of abnormal and induction of normal heart rate variabilityUS5724985 *Aug 2, 1995Mar 10, 1998Pacesetter, Inc.User interface for an implantable medical device using an integrated digitizer display screenUS5725559 *May 16, 1996Mar 10, 1998Intermedics Inc.Programmably upgradable implantable medical deviceUS5725561 *Jun 9, 1995Mar 10, 1998Medtronic, Inc.Method and apparatus for variable rate cardiac stimulationUS5730141 *Jun 7, 1996Mar 24, 1998Pacesetter, Inc.Tachyarrhythmia detection methodUS5730142 *Mar 21, 1997Mar 24, 1998Medtronic, Inc.Method and apparatus for detecting tachycardiaUS5738096 *Feb 1, 1996Apr 14, 1998Biosense, Inc.Cardiac electromechanicsUS5741304 *Oct 17, 1995Apr 21, 1998University Of Kentucky Research FoundationMultidirectional ECG coherent optimal timing of defibrillation shocksUS5741308 *May 15, 1995Apr 21, 1998Pacesetter, Inc.Dual-chamber implantable pacemaker and method of operating same for automatically setting the pacemaker's AV interval as a function of a natural measured conduction timeUS5855593 *Jun 12, 1997Jan 5, 1999Medtronic, Inc.Prioritized rule based method and apparatus for diagnosis and treatment for arrhythmiasUS5861007 *Feb 26, 1997Jan 19, 1999Medtronic, Inc.Adaptive search AV and auto PVARP adaptation to same with additional benefitUS5865838 *Sep 18, 1997Feb 2, 1999Pacesetter AbLow energy implantable atrial defibrillator using multiple electrodes and stimulation ratesUS5871507 *Jun 6, 1997Feb 16, 1999Pacesetter AbImplantable cardiac assist device having differential signal detection between unipolar atrial and ventricular leads using signal morphology analysisUS5873895 *Aug 3, 1998Feb 23, 1999Pacesetter, Inc.Pacemaker and method of operating same that provides functional atrial cardiac pacing with ventricular supportUS5873897 *Sep 19, 1997Feb 23, 1999Sulzer Intermedics Inc.Method and apparatus for dual chambered tachyarrhythmia classification and therapyUS5876422 *Jul 7, 1998Mar 2, 1999Vitatron Medical B.V.Pacemaker system with peltier cooling of A-V node for treating atrial fibrillationUS5891178 *May 13, 1997Apr 6, 1999Pacesetter, Inc.Programmer system and associated methods for rapidly evaluating and programming an implanted cardiac deviceUS5893882 *Dec 17, 1996Apr 13, 1999Medtronic, Inc.Method and apparatus for diagnosis and treatment of arrhythmiasUS5897575 *Oct 24, 1997Apr 27, 1999Pacesetter, Inc.Arrhythmia classification system with reliability indication that allows for low quality input signals in pacemakersUS6026320 *Jun 8, 1998Feb 15, 2000Cardiac Pacemakers, Inc.Heart rate variability as an indicator of exercise capacityUS6041251 *Jul 1, 1998Mar 21, 2000Cardiac Pacemakers, Inc.System and method for detecting atrial events of a heartUS6044298 *Oct 13, 1998Mar 28, 2000Cardiac Pacemakers, Inc.Optimization of pacing parameters based on measurement of integrated acoustic noiseUS6047210 *Sep 3, 1998Apr 4, 2000Cardiac Pacemakers, Inc.Cardioverter and method for cardioverting an atrial tachyarrhythmia while maintaining atrial pacingUS6049735 *Mar 1, 1999Apr 11, 2000Cardiac Pacemakers Inc.Cardiac rhythm management device with detection and therapy for sudden syncopal eventsUS6052617 *Jul 1, 1998Apr 18, 2000Cardiac Pacemakers, Inc.System and method for reliably detecting atrial events of a heart using only atrial sensingUS6052620 *Mar 25, 1998Apr 18, 2000Medtronic, Inc.Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmiasUS6219579 *Jan 28, 2000Apr 17, 2001Medtronic Inc.Four-chamber pacing system for optimizing cardiac output and determining heart conditionUS6351669 *May 21, 1999Feb 26, 2002Cardiac Pacemakers, Inc.Cardiac rhythm management system promoting atrial pacingUS6353759 *Oct 20, 2000Mar 5, 2002Cardiac Pacemakers, Inc.Cardiac rhythm management system promoting a trial pacingUS6353761 *Aug 20, 1999Mar 5, 2002Cardiac Pacemakers, Inc.Cardiac rhythm management system with user interface for threshold testUS6512951 *Sep 14, 2000Jan 28, 2003Cardiac Pacemakers, Inc.Delivery of atrial defibrillation shock based on estimated QT intervalUS6522925 *May 13, 2000Feb 18, 2003Cardiac Pacemakers, Inc.System and method for detection enhancement programmingUS6526317 *Jan 23, 2001Feb 25, 2003Cardiac Pacemakers, Inc.System and method for treating atrial arrhythmiasUS6687541 *Dec 30, 2002Feb 3, 2004Cardiac Pacemakers, Inc.Method for delivering atrial defibrillation therapyUS6847842 *May 15, 2000Jan 25, 2005Cardiac Pacemakers, Inc.Method and apparatus for reducing early recurrence of atrial fibrillation with defibrillation shock therapyUS6988002 *Nov 25, 2002Jan 17, 2006Cardiac Pacemakers, Inc.Apparatus and method for ventricular rate regularization with biventricular sensingUS7181278 *Mar 20, 2003Feb 20, 2007Cardiac Pacemakers, Inc.Apparatus and method for ventricular rate regularizationUS7184834 *Dec 5, 2003Feb 27, 2007Pacesetter, Inc.Method and apparatus for improving specificity of atrial tachycardia detection techniques in dual-unipolar or dual-bipolar implantable cardiac stimulation systemsUS7349734 *Dec 24, 2003Mar 25, 2008Cardiac Pacemakers, Inc.Method and apparatus for delivering defibrillation shock therapy while reducing electrical dispersion due to ventricular conduction disorderUS7680530 *May 3, 2006Mar 16, 2010Cardiac Pacemakers, Inc.Method and system for display of cardiac event intervals in a resynchronization pacemakerUS20030004551 *Aug 2, 2002Jan 2, 2003Cardiac Pacemakers, Inc.Cardiac rhythm management system with atrial shock timing optimizationUS20040010295 *Jun 13, 2003Jan 15, 2004Cardiac Pacemakers, Inc.Apparatus and method for ventricular rate regularizationUS20040015192 *Jun 24, 2003Jan 22, 2004Cardiac Pacemakers, Inc.Apparatus and method for R-wave detection with dual dynamic sensitivitiesUS20050038480 *Jul 12, 2004Feb 17, 2005Cardiac Pacemakers, Inc.Ventricular conduction delay trending system and methodUS20070016258 *Jun 12, 2006Jan 18, 2007Cardiac Pacemakers, Inc.Method and apparatus for treating irregular ventricular contractions such as during atrial arrhythmiaUS20070073348 *Oct 13, 2006Mar 29, 2007Cardiac Pacemakers, Inc.Apparatus and method for pacing mode switching during atrial tachyarrhythmiasUS20110015691 *Sep 27, 2010Jan 20, 2011Stahmann Jeffrey EApparatus and method for pacing mode switching during atrial tachyarrhythmias* Cited by examinerReferenced byCiting PatentFiling datePublication dateApplicantTitleUS7805192Oct 13, 2006Sep 28, 2010Cardiac Pacemakers, Inc.Apparatus and method for pacing mode switching during atrial tachyarrhythmiasUS7996086Sep 27, 2010Aug 9, 2011Cardiac Pacemarkers, Inc.Apparatus and method for pacing mode switching during atrial tachyarrhythmiasUS8064997Jun 12, 2006Nov 22, 2011Cardiac Pacemakers, Inc.Method and apparatus for treating irregular ventricular contractions such as during atrial arrhythmiaUS8239021Jun 15, 2010Aug 7, 2012Cardiac Pacemakers, Inc.Cardiac pacing system for prevention of ventricular fibrillation and ventricular tachycardia episodeUS8249703Feb 9, 2007Aug 21, 2012Cardiac Pacemakers, Inc.Apparatus and method for ventricular rate regularizationUS8391974Dec 20, 2010Mar 5, 2013Cardiac Pacemakers, Inc.Apparatus and method for pacing mode switching during atrial tachyarrhythmiasUS8512220Jun 7, 2007Aug 20, 2013Cardiac Pacemakers, Inc.Rate smoothing controlUS20070016258 *Jun 12, 2006Jan 18, 2007Cardiac Pacemakers, Inc.Method and apparatus for treating irregular ventricular contractions such as during atrial arrhythmiaUS20070073348 *Oct 13, 2006Mar 29, 2007Cardiac Pacemakers, Inc.Apparatus and method for pacing mode switching during atrial tachyarrhythmiasUS20070135853 *Feb 9, 2007Jun 14, 2007Cardiac Pacemakers, Inc.Apparatus and method for ventricular rate regularizationUS20070233201 *Jun 7, 2007Oct 4, 2007Cardiac Pacemakers, Inc.Rate smoothing controlUS20100249866 *Jun 15, 2010Sep 30, 2010Lovett Eric GCardiac pacing system for prevention of ventricular fibrillation and ventricular tachycardia episodeUS20110015691 *Sep 27, 2010Jan 20, 2011Stahmann Jeffrey EApparatus and method for pacing mode switching during atrial tachyarrhythmiasUS20110087303 *Dec 20, 2010Apr 14, 2011Stahmann Jeffrey EApparatus and method for pacing mode switching during atrial tachyarrhythmias* Cited by examinerClassifications U.S. Classification607/17International ClassificationA61N1/368Cooperative ClassificationA61N1/3956, A61N1/395, A61N1/3622European ClassificationA61N1/362A2, A61N1/39MLegal EventsDateCodeEventDescriptionAug 26, 2015FPAYFee paymentYear of fee payment: 4RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - 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