Source: https://patents.google.com/patent/US9851586B2/en
Timestamp: 2018-08-18 09:28:20
Document Index: 141095744

Matched Legal Cases: ['§119', 'Application No. 61', 'Application No. 10825787', 'Application No. 10825787', 'Application No. 98936282', 'Application No. 2011', 'Application No. 2011']

US9851586B2 - Contact lenses having a reinforcing scaffold - Google Patents
US9851586B2
US9851586B2 US15096442 US201615096442A US9851586B2 US 9851586 B2 US9851586 B2 US 9851586B2 US 15096442 US15096442 US 15096442 US 201615096442 A US201615096442 A US 201615096442A US 9851586 B2 US9851586 B2 US 9851586B2
US15096442
US20160223835A1 (en )
This application is a Continuation of U.S. application Ser. No. 14/539,698, filed on Nov. 12, 2014, which claims benefit under 35 U.S.C. §119(e) of U.S. Provisional Application No. 61/904,992, filed on Nov. 15, 2013, which is incorporated by reference in its entirety.
As used herein, an on K fit of a device such as a contact lens encompasses fitting the contact lens to the flattest meridian of the cornea and the on K fit can be flatter than the flattest meridian within about 1.5 D. For example, for a cornea having keratometer values (K values) of about 44 D axis 90 and 43 D axis 180, the on K fit would provide a device having a curvature corresponding to an optical power within a range from about 43 D to about 41.5 D for the region of the eye measured. The on K fit as described herein can allow for tear liquid to form under the device such that the tear liquid can be pumped in accordance with embodiments as described herein.
FIGS. 1A-1D show various views of a contact lens having a scaffold. FIG. 1D shows a cross-section of a contact lens having an inner optic portion 101, peripheral portion 102, anterior surface 103, and posterior surface 104. Inner optic portion 101 includes anterior portion 105, center portion 106, and posterior portion 107. Center portion 106 is characterized by a substantially uniform thickness and is embedded between anterior portion 105 and posterior portion 107. As suggested by FIG. 1D, anterior portion 105, posterior portion 107, and peripheral portion 102 may be formed from the same material, and center portion 106 may be formed from a different material. In certain embodiments, center portion 106 also includes openings, which are not shown in FIG. 1D. The anterior surface 103 and the posterior surface 104 of the inner optic portion are characterized by a spherically symmetric profile. A center portion may have the same diameter as the inner portion, may have a diameter greater than that of the inner portion, or may have a diameter smaller than that of the inner portion. The inner portion may have a diameter that is larger than the inner optic portion through which the eye sees.
In certain embodiments, the round openings may have a diameter ranging from 10 μm to 1000 μm including, for example, 50 μm to 500 μm, 100 μm to 500 μm, or 50 μm to 250 μm. In certain embodiments, the openings may have at least one dimension ranging from 10 μm to 1000 μm including, for example, 50 μm to 500 μm, 100 μm to 500 μm, or 50 μm to 250 μm.
Dk t = 100 * ( s b ( t a Dk a + t b Dk b + t d Dk d ) + s c ( t a Dk a + t c Dk c + t d Dk d ) ) ( 1 ) Rigidity = t t 3 ⁡ ( E a * f a + s a * E b * f b + s c * Ec * f c + E d * f d ) ( 2 )
sx=fractional amount of material “x” that exists across thickness t, (for an un-modified disc: sx=1)
A lenticular volume defined by the peripheral portion of a lens may be fluidly connected to a lenticular volume defined by the inner portion and may facilitate exchange of tear fluid within one or more lenticular volumes. Tear exchange within a lenticular volume and to and from a lenticular volume may be facilitated by fenestrations through the ophthalmic lens. Such fenestrations may serve to pump tear fluid to and from a lenticular volume during blinking of the eye.
1. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
an inner optic portion configured to be disposed over an optical region of the cornea, wherein the inner optic portion comprises:
an inner material; and
a scaffold embedded within the inner material, wherein the scaffold comprises one or more openings; and
a peripheral portion disposed radially outward of the inner optic portion.
2. The ophthalmic lens of claim 1, wherein, when applied to the eye, the inner optic portion comprises a posterior surface characterized by a shape diverging from a refractive shape of the cornea.
3. The ophthalmic lens of claim 1, wherein,
the inner material is characterized by an inner material modulus;
the scaffold modulus is greater than the inner material modulus.
4. The ophthalmic lens of claim 3, wherein the scaffold modulus is within a range from 300 MPa to 3000 MPa.
5. The ophthalmic lens of claim 3, wherein the inner material modulus is within a range from 0.1 MPa to 10 MPa.
6. The ophthalmic lens of claim 1, wherein the scaffold is characterized by a substantially uniform thickness.
7. The ophthalmic lens of claim 1, wherein the scaffold is characterized by a substantially uniform thickness ranging from 50 μm to 500 μm.
8. The ophthalmic lens of claim 1, wherein the scaffold represents from 20 vol % to 80 vol % of the volume of the inner optic portion.
9. The ophthalmic lens of claim 1, wherein the inner optic portion is characterized by a maximum thickness from 50 μm to 500 μm.
10. The ophthalmic lens of claim 1, wherein the inner optic portion is characterized by a rigidity from 1E9 MPa-μm3 to 1E11 MPa-μm3.
11. The ophthalmic lens of claim 1, wherein the inner optic portion is characterized by an oxygen transmissibility of at least 80 Dk/t.
12. The ophthalmic lens of claim 1, wherein the inner optic portion comprises an anterior surface and a posterior surface wherein each of the anterior surface and the posterior surface is characterized by a spherical profile.
13. The ophthalmic lens of claim 1, further comprising a plurality of fenestrations, wherein the plurality of fenestrations is disposed within the inner optic portion, within the peripheral portion, or within both the inner optic portion and the peripheral portion.
14. The ophthalmic lens of claim 1, wherein,
each of an anterior surface of the inner optic portion and a posterior surface of the inner optic portion is radially symmetric.
15. The ophthalmic lens of claim 1, wherein the one or more openings are filled with the inner material.
16. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
a scaffold embedded within the inner material; and
wherein each of the inner material and the scaffold material comprise similar material chemistries.
17. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
wherein each of the inner material and the scaffold material comprises a hydrogel.
18. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
wherein each of the inner material and the scaffold material is characterized by substantially the same refractive index within +/−0.02.
19. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
20. An ophthalmic lens for correcting a refractive error of an eye, wherein the eye comprises a cornea, and the ophthalmic lens comprises:
a scaffold embedded within the inner material, wherein the scaffold comprises a scaffold material; and
wherein the inner material and the scaffold material exhibit similar swelling when hydrated.
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