Source: https://patents.google.com/patent/US5820852A/en
Timestamp: 2019-07-24 00:45:03
Document Index: 387711323

Matched Legal Cases: ['application No. 08', 'application No. 08', 'application No. 08', 'application No. 08', 'application No. 08', 'application No. 08']

US5820852A - Oral compositions containing fluoride, pyrophosphate, and peroxide - Google Patents
Oral compositions containing fluoride, pyrophosphate, and peroxide Download PDF
US5820852A
US5820852A US08/756,740 US75674096A US5820852A US 5820852 A US5820852 A US 5820852A US 75674096 A US75674096 A US 75674096A US 5820852 A US5820852 A US 5820852A
US08/756,740
1996-11-26 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
1996-11-26 Priority to US08/756,740 priority Critical patent/US5820852A/en
1997-02-27 Assigned to PROCTER & GAMBLE COMPANY, THE reassignment PROCTER & GAMBLE COMPANY, THE ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BURGESS, STEVEN CARL, SHEETS, CONNIE LYNN
1998-10-13 Publication of US5820852A publication Critical patent/US5820852A/en
The present invention relates to an oral compositions comprising a soluble fluoride ion source, tetrasodium pyrophosphate, calcium peroxide, and one or more aqueous carriers, wherein the oral composition has a neat pH of from about 9.0 to about 10.5 and a total water content of from about 9.1% to about 20%. The invention may also include an alkali metal bicarbonate salt and xylitol.
The present invention relates to stable oral compositions containing fluoride, pyrophosphate, and calcium peroxide, wherein the total water content and pH are controlled.
Although peroxide products containing tartar control ingredients and fluoride are known, there is a continuing need to develop improved products. The present inventors have discovered that a stable oral composition can be formulated to include a soluble fluoride ion source, pyrophosphate, and calcium peroxide by controlling the total water content and the pH. It has also been discovered that these oral compositions may also contain an alkali metal bicarbonate salt and xylitol while still maintaining good stability.
It is therefore an object of the present invention to provide a stable tartar control composition that contains a soluble fluoride ion source and calcium peroxide. It is also an object of the present invention to provide a tartar control composition that contains a soluble fluoride ion source, calcium peroxide, an alkali metal bicarbonate salt, and xylitol. A further object of the present invention is to provide compositions which deliver a variety of benefits to the mouth, such as those described above, and compositions having improved aesthetics.
The present invention relates to an oral composition comprising a soluble fluoride ion source capable of providing from about 50 ppm to about 3500 ppm of free fluoride ions, an amount of at least about 1.5% tetrasodium pyrophosphate, from about 0.01% to about 5% of calcium peroxide, and from about 80% to about 98% of one or more aqueous carriers, wherein the oral composition has a neat pH of from about 9.0 to about 10.5 and a total water content of from about 9.1% to about 20%. The invention may also include from about 0.5% to about 40% of an alkali metal bicarbonate salt and from about 0.01% to about 25% of xylitol.
The present invention relates to oral compositions comprising fluoride, tetrasodium pyrophosphate, and calcium peroxide. These compositions can also include an alkali metal bicarbonate salt and xylitol.
The oral compositions of the present invention may be in the form of a toothpaste. The term "toothpaste", as used herein, means paste, gel, or liquid formulations unless otherwise specified. The toothpaste may be in any desired form, such as deep striped, surface striped, mulitlayered, having the gel surrounding the paste, or any combination thereof. The toothpaste may also be a multilayer composition which is extruded from the tube in combination paste/gel stripes. One of the layers must comprise all of the essential components, while the other layers may contain less than all of the essential components or may be any dentifrice formulation.
The term "aqueous carrier" as used herein means any safe and effective materials for use in the compositions of the present invention. Such materials include thickening materials, humectants, water, buffering agents, abrasive polishing materials, surfactants, titanium dioxide, flavor system, sweetening agents, coloring agents, and mixtures thereof.
Tetrasodium pyrophosphate may be the anhydrous salt form or the decahydrate form, or any other species stable in solid form in the dentifrice compositions. The anhydrous salt is in its solid particle form, which may be its crystalline and/or amorphous state, with the particle size of the salt preferably being small enough to be aesthetically acceptable and readily soluble during use. The amount of pyrophosphate salt useful in making these compositions is any tartar control effective amount, and is generally from about 1.5% to about 15%, preferably from about 2% to about 10%, and most preferably from about 3% to about 8%, by weight of the composition. Some or all of the tetrasodium pyrophosphate is undissolved in the product and is present as tetrasodium pyrophosphate particles. Pyrophosphate ions in different protonated states (e.g., HP2 O7 -3) may also exist depending upon the pH of the composition and if part of the tetrasodium pyrophosphate is dissolved.
Water is also contained in the present invention. Water used in the preparation of these compositions should preferably be of low ion content and free of organic impurities. The "total water content" of the composition, as used herein, includes the free water which is added plus the water which is introduced with other materials, such as with sorbitol, silica, color solutions, or surfactant solutions. The total water content of the present invention is from about 9.1% to about 20%, preferably from about 0.2% to about 14%, more preferably from about 9.5% to about 13%, and most preferably from about 10% to about 11%, by weight of the total composition.
The present invention may also include an alkali metal bicarbonate salt.
Alkali metal bicarbonate salts are soluble in water and unless stabilized, tend to release carbon dioxide in an aqueous system. Sodium bicarbonate, also known as baking soda, is the preferred alkali metal bicarbonate salt. The present compositions may contain from about 0.5% to about 40%, preferably from about 0.5% to about 20%, more preferably from about 0.5% to about 5%, and most preferably from about 0.8% to about 2% of an alkali metal bicarbonate salt, by weight of the total composition.
In preparing the present compositions, it is desirable to add one or more aqueous carriers to the compositions. Aqueous carriers contain materials that are well known in the art and readily chosen by one skilled in the art based on the physical and aesthetic properties desired for the compositions being prepared. Aqueous carriers typically comprise from about 80% to about 98%, and preferably from about 85% to about 95%, by weight of the total composition.
Another optional component of the compositions desired herein is a humectant. The humectant serves to keep toothpaste compositions from hardening upon exposure to air and certain humectants can also impart desirable sweetness of flavor to toothpaste compositions. Suitable humectants for use in the invention include glycerin, sorbitol, polyethylene glycol, propylene glycol, and other edible polyhydric alcohols. Polyethylene glycols are one of the preferred humectants.
Polyethylene glycols useful herein are those which are liquids at room temperature or have a melting point slightly there above. Liquid and low-melting polyethylene glycols are commercially available from Union Carbide under the Carbowax® tradename. Preferred are those polyethylene glycols having a molecular weight range of from about 200 to about 2000 and corresponding n values of from about 4 to about 40. More preferred are polyethylene glycols having a molecular weight range of from about 400 to about 1600 and most preferred are polyethylene glycols having a molecular weight range of from about 570 to about 630. The humectant generally comprises from about 0% to 70%, and preferably from about 15% to 55%, by weight of the compositions herein.
Silica dental abrasives of various types are preferred because of their unique benefits of exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentine. The silica abrasive polishing materials herein, as well as other abrasives, generally have an average particle size ranging between about 0.1 to about 30 microns, and preferably from about 5 to about 15 microns.
The abrasive can be precipitated silica or silica gels such as the silica xerogels described in Pader et al., U.S. Pat. No. 3,538,230, issued Mar. 2, 1970, and DiGiulio, U.S. Pat. No. 3,862,307, issued Jan. 21, 1975, both incorporated herein by reference.
Preferred are the silica xerogels marketed under the trade name "Syloid" by the W.R. Grace & Company, Davison Chemical Division. Also preferred are the precipitated silica materials such as those marketed by the J. M. Huber Corporation under the trade name, "Zeodent", particularly the silica carrying the designation "Zeodent 119". The types of silica dental abrasives useful in the toothpastes of the present invention are described in more detail in Wason, U.S. Pat. No. 4,340,583, issued Jul. 29, 1982, incorporated herein by reference. The abrasive in the toothpaste compositions described herein is generally present at a level of from about 6% to about 70%, by weight of the composition. Preferably, toothpastes contain from about 10% to about 50% of abrasive, by weight of the composition.
The present composition may also comprise surfactants, also commonly referred to as sudsing agents. Suitable surfactants are those which are reasonably stable and foam throughout a wide pH range. The surfactant may be anionic, nonionic, amphoteric, zwitterionic, cationic, or mixtures thereof. Anionic surfactants useful herein include the water-soluble salts of alkyl sulfates having from 8 to 20 carbon atoms in the alkyl radical (e.g., sodium alkyl sulfate) and the water-soluble salts of sulfonated monoglycerides of fatty acids having from 8 to 20 carbon atoms. Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type. Other suitable anionic surfactants are sarcosinates, such as sodium lauroyl sarcosinate, taurates, sodium lauryl sulfoacetate, sodium lauroyl isethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate. Mixtures of anionic surfactants can also be employed. Many suitable anionic surfactants are disclosed by Agricola et al., U.S. Pat. No. 3,959,458, issued May 25, 1976, incorporated herein in its entirety by reference. Nonionic surfactants which can be used in the compositions of the present invention can be broadly defined as compounds produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkyl-aromatic in nature. Examples of suitable nonionic surfactants include poloxamers (sold under trade name Pluronic), polyoxyethylene sorbitan esters (sold under trade name Tweens), fatty alcohol ethoxylates, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with the reaction product of propylene oxide and ethylene diamine, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyl sulfoxides, and mixtures of such materials. The amphoteric surfactants useful in the present invention can be broadly described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be a straight chain or branched and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic water-solubilizing group, e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate. Other suitable amphoteric surfactants are betaines, specifically cocamidopropyl betaine. Mixtures of amphoteric surfactants can also be employed. Many of these suitable nonionic and amphoteric surfactants are disclosed by Gieske et al., U.S. Pat. No. 4,051,234, issued Sep. 27, 1977, incorporated herein by reference in its entirety. The present compositions may comprise one or more surfactants each at a level of from about 0.25% to about 10%, preferably from about 0.5% to about 8%, and most preferably from about 1% to about 6%, by weight of the composition.
Titanium dioxide may also be added to the present composition. Titanium dioxide is a white powder which adds opacity to the compositions. Titanium dioxide may comprise from about 0.25% to about 5%, by weight of the compositions.
A flavor system can also be added to the compositions. Suitable flavoring components include oil of wintergreen, oil of peppermint, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, diacetyl, methyl-para-tert-butyl phenyl acetate, and mixtures thereof. Coolants may also be part of the flavor system. Preferred coolants in the present compositions are the paramenthan carboxyamide agents such as N-ethyl-p-menthan-3-carboxamide (known commercially as "WS-3") and mixtures thereof. A flavor system is generally used in the compositions at levels of from about 0.001% to about 5%, by weight of the composition.
Sweetening agents can be added to the compositions. These include sodium saccharin, dextrose, sucrose, lactose, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrochalcones, acesulfame, and mixtures thereof. Sweetening agents are generally used in toothpastes at levels of from about 0.005% to about 5%, by weight of the composition.
The composition may be a multilayer toothpaste composition. This composition may comprise two or more separate layers which are in contact with each other. Preferably, the separate layers are pastes and gels that when extruded from the tube, appear as combination paste/gel stripes. One of the layers in this paste/gel stripe combination must comprise all of the essential components, while the other layers may contain less than all of the essential components and may be any dentifrice formulation. Preferably, the gel layers do not comprise the essential component of calcium peroxide.
Alternatively, the dentifrice compositions may be physically separated in a dentifrice dispenser. The dispenser may be a tube, pump, or any other container suitable for dispensing toothpaste. Dual compartment packages suitable for this purpose are described in U.S. Pat. No. 4,528,180, issued Jul. 9, 1985; U.S. Pat. No. 4,687,663, issued Aug. 18, 1987; and U.S. Pat. No. 4,849,213, issued Jul. 18, 1989, all to Shaeffer, all incorporated herein in their entirety. The dispenser will deliver approximately equal amounts of each dentifrice composition through an opening. The compositions may intermix once dispensed. Alternatively, the oral formulation may be delivered from a kit containing two separate dispensers which are used to deliver two dentifrice compositions that are both used simultaneously.
Toothpaste compositions comprising a soluble fluoride source capable of providing from about 50 ppm to about 3500 ppm of free fluoride ions, an amount of at least about 1.5% tetrasodium pyrophosphate, from about 0.01% to about 5% of calcium peroxide; and from about 80% to about 98% of one or more aqueous carriers, are made by a process comprising the steps of: (a) preparing a mixture of a soluble fluoride ion source and one or more aqueous carrier materials; (b) adding tetrasodium pyrophosphate and calcium peroxide, all at once or in portions, under conditions wherein less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the dentifrice mixture; and wherein further any remaining aqueous carrier materials not added to the mixture during step (a) are added in whole or in part in step (b) or thereafter, either by themselves or with any remaining amount of the tetrasodium pyrophosphate or calcium peroxide, under conditions such that less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the mixture; and (c) heating the mixture to a temperature range of from about 38° C. (100° F.) to about 71° C. (160° F.) and preferably to a temperature range of from about 52° C. (125° F.) to about 57° C. (135° F.). The amount of pyrophosphate dissolved in the mixture for the methods and compositions of the present invention is preferably less than about 10% by weight of the total pyrophosphate present in the compositions and the amount of calcium peroxide dissolved in the mixtures is preferably less than about 10% by weight of the total amount of calcium peroxide present in the compositions.
Preferably, one or more of the following process conditions are controlled as follows to limit the solubility of the tetrasodium pyrophosphate and calcium peroxide in the dentifrice mixture: (1) the neat pH of the process mixture is above about pH 8, preferably above about pH 9, during and after the tetrasodium pyrophosphate and calcium peroxide additions are made to the mixture; and (2) the tetrasodium pyrophosphate salt and peroxide are two of the last components to be added to the mixture, preferably after all or much of the other sodium-containing salts present in the composition have been added to the mixture. By these methods, the dissolved tetrasodium pyrophosphate salt is less likely to recrystalize in the form of glass-like crystal particles of tetrasodium pyrophosphate decahydrate and the peroxide is less likely to breakdown and react with the fluoride to form calcium fluoride.
After step (c), the toothpaste is fed into a suitable dispensing tube or container. After filling the tube with toothpaste, the open end of the tube is sealed. If the toothpaste is to be a multilayer composition, the desired toothpaste layers are led in parallel streams to form a multilayered appearance and then the op en end of the tube is sealed. The dentifrice layers will be extruded in the desired multilayer configuration when dispensed from the tube.
______________________________________Ingredient         Weight %______________________________________Glycerin           28.885Polyethylene Glycol 12              1.000Xanthan Gum        0.300Carboxymethylcellulose              0.200Water              5.000Sodium Saccharin   0.450Sodium Fluoride    0.243Poloxamer 407      2.000Sodium Alkyl Sulfate .sup.(a)              6.000Flavor             1.150Sodium Carbonate   2.800Titanium Dioxide   1.000Silica             20.000Sodium Bicarbonate 10.000Propylene Glycol   10.562Tetrasodium Pyrophosphate              8.410Calcium Peroxide   2.000______________________________________
Example I is prepared as follows: Add approximately half of the glycerin to a mixing vessel. Disperse the thickening agents, carboxymethyl cellulose and xanthan gum, in the propylene glycol. Add this mixture of dispersed thickening agents in propylene glycol to the mixing vessel and add the polyethylene glycol. Dissolve the is sodium fluoride and sodium saccharin in water and add to the mixture. Add the poloxamer. The flavor and sodium alkyl sulfate are then added. Next, add the sodium carbonate, titanium dioxide, and the silica. Add the sodium bicarbonate. Disperse the tetrasodium pyrophosphate in the remaining glycerin and add to the mixture. Finally, add the calcium peroxide. Stir the mixture until homogeneous and then heat the mixture to a temperature range of from about 110° F. to about 160° F. This temperature should be maintained for about 30-60 minutes. Finally, the mixture may be cooled and deaerated.
______________________________________Ingredient         Weight %______________________________________Glycerin           28.990Polyethylene Glycol 12              3.000Xanthan Gum        0.400Carboxymethylcellulose              0.250Water              5.000Sodium Saccharin   0.450Sodium Fluoride    0.243Xylitol            10.000Poloxamer 407      3.000Sodium Alkyl Sulfate .sup.(a)              6.000Flavor             1.150Sodium Carbonate   2.800Titanium Dioxide   1.000Silica             20.000Sodium Bicarbonate 1.000Propylene Glycol   11.571Tetrasodium Pyrophosphate              5.046Calcium Peroxide   0.100______________________________________
______________________________________Ingredient         Weight %______________________________________Glycerin           27.050Polyethylene Glycol 12              2.000Xanthan Gum        0.300Carboxymethylcellulose              0.200Water              5.000Sodium Saccharin   0.450Sodium Fluoride    0.243Xylitol            10.000Poloxamer 407      2.000Sodium Alkyl Sulfate .sup.(a)              6.000Flavor             1.100Sodium Carbonate   2.600Titanium Dioxide   1.000Silica             20.000Sodium Bicarbonate 1.500Propylene Glycol   15.011Tetrasodium Pyrophosphate              5.046Calcium Peroxide   0.500______________________________________
Examples II and III are prepared as follows: Add approximately half of the glycerin to a mixing vessel. Disperse the thickening agents, carboxymethyl cellulose and xanthan gum, in the propylene glycol. Add this mixture of dispersed thickening agents in propylene glycol to the mixing vessel and add the polyethylene glycol. Dissolve the sodium fluoride and sodium saccharin in water and add to the mixture. Add the xylitol and poloxamer. The flavor and sodium alkyl sulfate are then added. Next, add the sodium carbonate, titanium dioxide, and the silica. Add the sodium bicarbonate. Disperse the tetrasodium pyrophosphate in the remaining glycerin and add to the mixture. Finally, add the calcium peroxide. Stir the mixture until homogeneous and then heat the mixture to a temperature range of from about 110° F. to about 160° F. This temperature should be maintained for about 30-60 minutes. Finally, the mixture may be cooled and deaerated.
______________________________________Ingredient         Weight %______________________________________Glycerin           28.611Polyethylene Glycol 6              1.000Xanthan Gum        0.350Carboxymethylcellulose              0.250Water              6.400Sodium Saccharin   0.300Sodium Fluoride    0.243Sodium Alkyl Sulfate .sup.(a)              6.000Flavor             0.900Sodium Carbonate   2.800Titanium Dioxide   0.500Silica             10.000Sodium Bicarbonate 30.000Propylene Glycol   7.500Tetrasodium Pyrophosphate              5.046Calcium Peroxide   0.100______________________________________
Example IV is prepared as follows: Add approximately half of the glycerin to a mixing vessel. Disperse the thickening agents, carboxymethyl cellulose and xanthan gum, in the propylene glycol. Add this mixture of dispersed thickening agents in propylene glycol to the mixing vessel and add the polyethylene glycol. Dissolve the sodium fluoride and sodium saccharin in water and add to the mixture. The flavor and sodium alkyl sulfate are then added. Next, add the sodium carbonate, titanium dioxide, and the silica. Add the sodium bicarbonate. Disperse the tetrasodium pyrophosphate in the remaining glycerin and add to the mixture. Finally, add the calcium peroxide. Stir the mixture until homogeneous and then heat the mixture to a temperature range of from about 110° F. to about 160° F. This temperature should be maintained for about 30-60 minutes. Finally, the mixture may be cooled and deaerated.
______________________________________Ingredient         Weight %______________________________________Glycerin           24.461Polyethylene Glycol 12              1.000Xanthan Gum        0.500Carboxymethylcellulose              0.350Water              11.500Sodium Saccharin   0.450Sodium Fluoride    0.243Xylitol            20.000Sodium Alkyl Sulfate .sup.(a)              6.000Flavor             1.150Sodium Carbonate   2.800Titanium Dioxide   1.000Silica             15.000Propylene Glycol   10.000Tetrasodium Pyrophosphate              5.046Calcium Peroxide   0.500______________________________________ .sup.(a)  27.9% solution of sodium alkyl sulfate in water
Example V is prepared as follows: Add approximately half of the glycerin to a mixing vessel. Disperse the thickening agents, carboxymethyl cellulose and xanthan gum, in the propylene glycol. Add this mixture of dispersed thickening agents in propylene glycol to the mixing vessel and add the polyethylene glycol. Dissolve the sodium fluoride and sodium saccharin in water and add to the mixture. Add the xylitol. The flavor and sodium alkyl sulfate are then added. Next add the sodium carbonate, titanium dioxide, and the silica. Disperse the tetrasodium pyrophosphate in the remaining glycerin and add to the mixture. Finally, add the calcium peroxide. Stir the mixture until homogeneous and then heat the mixture to a temperature range of from about 110° F. to about 160° F. This temperature should be maintained for about 30-60 minutes. Finally, the mixture may be cooled and deaerated.
d. from about 80% to about 98% of one or more aqueous carriers;
wherein the oral composition has a neat pH of from about 9.0 to about 10.5 and a total water content of from 9.1% to about 20%.
5. The oral composition according to claim 4 wherein the neat pH is from about 9.2 to about 10.2.
6. The oral composition according to claim 5 where the total water content is from about 9.2% to about 14%.
7. The oral composition according to claim 6 wherein the aqueous carriers contain materials selected from the group consisting of thickening materials, humectants, water, buffering agents, abrasive polishing materials, surfactants, titanium dioxide, flavor system, sweetening agents, coloring agents, and mixtures thereof.
8. The oral composition according to claim 7 wherein the composition is a multilayer composition which is extruded from a tube in combination paste/gel stripes.
9. An oral composition comprising:
c. from about 0.01% to about 5.0% of calcium peroxide;
d. from about 0.5% to about 40% of an alkali metal bicarbonate salt; and
e. from about 80% to about 98% of one or more aqueous carriers;
wherein the oral composition has a neat pH of from about 9.0 to about 10.5 and a total water content of from about 9.1% to about 20%.
10. The oral composition according to claim 9 wherein the soluble fluoride source is sodium fluoride.
11. The oral composition according to claim 10 wherein the composition comprises from about 1.5% to about 15% tetrasodium pyrophosphate of which some or all of the tetrasodium pyrophosphate is undissolved in the product and is present as tetrasodium pyrophosphate particles.
12. The oral composition according to claim 11 wherein the calcium peroxide is in an amount of from about 0.1% to about 3.0%.
13. The oral composition according to claim 12 wherein the neat pH is from about 9.2 to about 10.2.
14. The oral composition according to claim 13 where the total water content is from about 0.2% to about 14%.
15. The oral composition according to claim 14 further comprising from about 0.01% to about 25% of xylitol.
16. The oral composition according to claim 15 wherein the aqueous carriers contain materials selected from the group consisting of thickening materials, humectants, water, buffering agents, abrasive polishing materials, surfactants, titanium dioxide, flavor system, sweetening agents, coloring agents, and mixtures thereof.
17. The oral composition according to claim 16 wherein the composition is a multilayer composition which is extruded from a tube in combination paste/gel stripes.
18. A method for reducing the incidence of calculus on dental enamel comprising contacting the enamel surfaces in the mouth with the oral composition according to claim 2.
19. A method for reducing the incidence of calculus on dental enamel comprising contacting the enamel surfaces in the mouth with the oral composition according to claim 10.
20. The oral composition comprising a soluble fluoride source capable of providing from about 50 ppm to about 3500 ppm of free fluoride ions; an amount of at least about 1.5% tetrasodium pyrophosphate; from about 0.01% to about 5% of calcium peroxide; and from about 80% to about 98% of one or more aqueous carriers;
wherein the oral composition has a neat pH of from about 9.0 to about 10.5 and a total water content of from about 9.1% to 20%, produced according to a process comprising the steps of:
a. preparing a mixture of a soluble fluoride source and one or more aqueous carrier materials;
b. adding tetrasodium pyrophosphate and calcium peroxide, all at once or in portions, under conditions wherein less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the mixture, and wherein any further remaining aqueous carrier materials is not added to the mixtures during step (a) are added in whole or in part in step (b) or thereafter, either by themselves or with any remaining amount of the tetrasodium pyrophosphate or calcium peroxide under conditions such that less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the mixture; and
US08/756,740 1996-11-26 1996-11-26 Oral compositions containing fluoride, pyrophosphate, and peroxide Expired - Fee Related US5820852A (en)
US08/756,740 US5820852A (en) 1996-11-26 1996-11-26 Oral compositions containing fluoride, pyrophosphate, and peroxide
PCT/US1997/021151 WO1998023248A1 (en) 1996-11-26 1997-11-19 Oral compositions containing fluoride, pyrophosphate, and peroxide
CA 2271796 CA2271796A1 (en) 1996-11-26 1997-11-19 Oral compositions containing fluoride, pyrophosphate, and peroxide
EP19970949487 EP0941048A1 (en) 1996-11-26 1997-11-19 Oral compositions containing fluoride, pyrophosphate, and peroxide
CN 97180029 CN1238674A (en) 1996-11-26 1997-11-19 Oral compositions containing fluoride, pyrophosphate and peroxide
US5820852A true US5820852A (en) 1998-10-13
ID=25044853
US08/756,740 Expired - Fee Related US5820852A (en) 1996-11-26 1996-11-26 Oral compositions containing fluoride, pyrophosphate, and peroxide
US (1) US5820852A (en)
EP (1) EP0941048A1 (en)
CN (1) CN1238674A (en)
CA (1) CA2271796A1 (en)
WO (1) WO1998023248A1 (en)
US20130095045A1 (en) * 2010-06-23 2013-04-18 Brian Joseph Groves Non-aqueous oral care compositions
US9333154B2 (en) * 2012-01-12 2016-05-10 M & O Solutions, Llc Dual component oral composition for enhancing remineralization of teeth
US9364419B2 (en) * 2014-05-15 2016-06-14 The Procter & Gamble Company Oral care compositions containing polyethylene glycol for physical stability
ITMI20120883A1 (en) 2012-05-22 2013-11-23 Brux S R L New formulation for the prevention of dental caries
CA2891639A1 (en) 2012-12-14 2014-06-19 Colgate-Palmolive Company Peroxide-stable oral care compositions
CA2162885A1 (en) * 1994-11-14 1996-05-15 Donald P. Hsu Stabilized dentifrice compositions containing reactive ingredients
CA2162812A1 (en) * 1994-11-14 1996-05-15 John Santalucia Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds
CA2162821A1 (en) * 1994-11-14 1996-05-15 Donald P. Hsu Multilayer bicarbonate/peroxide dentifrice
EP0712624A2 (en) * 1994-11-14 1996-05-22 Colgate-Palmolive Company Dentifrice compositions having improved anticalculus properties
WO1997046462A1 (en) * 1996-06-06 1997-12-11 Colgate-Palmolive Company Codispensing of physically segregated dentifrices at consistant ratios
1996-11-26 US US08/756,740 patent/US5820852A/en not_active Expired - Fee Related
1997-11-19 CN CN 97180029 patent/CN1238674A/en not_active Application Discontinuation
1997-11-19 WO PCT/US1997/021151 patent/WO1998023248A1/en not_active Application Discontinuation
1997-11-19 CA CA 2271796 patent/CA2271796A1/en not_active Abandoned
1997-11-19 EP EP19970949487 patent/EP0941048A1/en not_active Withdrawn
U.S. application No. 08/334,635, Huetter, filed Nov. 4, 1994. *
U.S. application No. 08/365,975, Huetter, filed Dec. 28 1994. *
U.S. application No. 08/756,015, Burgess, et al., Nov. 26, 1996. *
U.S. application No. 08/756,671, Sanker, et al., Nov. 26, 1996. *
U.S. application No. 08/756,995, Burgess et al., Nov. 26, 1996. *
U.S. application No. 08/756450, Burgess, et al. Nov. 26, 1996. *
US9877911B2 (en) * 2010-06-23 2018-01-30 Conopco, Inc. Non-aqueous oral care compositions
EP0941048A1 (en) 1999-09-15
CN1238674A (en) 1999-12-15
CA2271796A1 (en) 1998-06-04
WO1998023248A1 (en) 1998-06-04
CA1333259C (en) 1994-11-29 Anticalculus oral composition
EP1227789B1 (en) 2004-09-22 Improved dual phase stannous oral compositions
EP0712624B1 (en) 2003-02-05 Dentifrice compositions having improved anticalculus properties
CA2162812C (en) 2008-03-25 Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds
CA2162821C (en) 2007-04-10 Multilayer bicarbonate/peroxide dentifrice
EP0579729B1 (en) 1998-11-11 Quaternary ammonium antibacterial dentifrices with selected calcium abrasives
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BURGESS, STEVEN CARL;SHEETS, CONNIE LYNN;REEL/FRAME:008400/0009