Source: https://patents.google.com/patent/WO1986001115A1/en
Timestamp: 2019-07-21 15:37:38
Document Index: 344619225

Matched Legal Cases: ['arts 106', 'art 110', 'art 110', 'arts 201', 'arts 206', 'art 210', 'art 210', 'art 210', 'art 210', 'art.\n3']

WO1986001115A1 - Device for pumping liquids which are highly sensitive to mechanical strains - Google Patents
Device for pumping liquids which are highly sensitive to mechanical strains Download PDF
WO1986001115A1
WO1986001115A1 PCT/EP1985/000393 EP8500393W WO8601115A1 WO 1986001115 A1 WO1986001115 A1 WO 1986001115A1 EP 8500393 W EP8500393 W EP 8500393W WO 8601115 A1 WO8601115 A1 WO 8601115A1
PCT/EP1985/000393
Karl-Theo Braun
Braun Karl Theo
1984-08-04 Priority to DEP3428828.7 priority Critical
1984-08-04 Priority to DE3428828A priority patent/DE3428828C2/de
1985-08-05 Application filed by Braun Karl Theo filed Critical Braun Karl Theo
1985-08-05 Priority claimed from AT85904103T external-priority patent/AT52035T/en
1985-08-05 Priority claimed from DE19853577186 external-priority patent/DE3577186D1/en
1986-02-27 Publication of WO1986001115A1 publication Critical patent/WO1986001115A1/en
1998-06-30 First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6242381&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1986001115(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
A device for pumping liquids which are highly sensitive to mechanical strains may be conveniently used in hemodialysis, ultrafiltration, hemofiltration and plasma separation apparatuses in order to provide for blood circulation. The pumping device comprises a rigid casing (103; 203) which has a flexible wall part (102; 202) and a sealed cavity (101; 201) with variable volume. The sealed cavity (101; 201) contains a working medium and is connected by means of a conduit (104; 204) to a pressure generator. The rigid casing (103; 203) has also a liquid-tight circulation chamber for the liquid to be circulated, which chamber is provided with supply and discharge conduits (108, 109; 208, 209) and comprises at least a flexible wall part (106; 206). The flexible walls of the casing (102; 202) and of the circulation chamber (106; 206) are arranged facing each other and their surfaces are susceptible of being brought into contact.
Pump device for conveying to mechanical stress highly sensitive liquids
The invention relates to a pumping device for conveying highly sensitive to mechanical stresses liquids. A liquid, for which applies this description is blood.
The invention can therefore treatment devices with particular advantage in Blutbe¬ as Hae odi alyse-, INtrafi 1 trati ONS, Haemofi 1trations- and plasma separation devices are used.
Human blood is a highly sensitive to mechanical Beanspru¬ chung liquid, for example, easily tends Quetschbelastungen under a permanent hemolysis and coagulation rate.
For reasons of sterility must conveying devices, which are used for the extra-corporal s blood transport to filters or exchange membranes or the like, are generally exchanged in any application with new sterile plants.
For this reason, one is dependent on hose pumps in which sterile tubing is used before reuse. These peristaltic pumps a wheel rolls over the hose and squeezing the hose together and thus presses the blood in the tube by its forward Abrol1bewegungen in the hose.
These peristaltic pumps have considerable disadvantages. On the one hand, these pumps require the blood to a high degree me¬ mechanically, so that hemolysis and coagulation rate remain. Furthermore, they produce a constant abrasion which enters the human body and can not be dismantled. On the other hand, it is with these peristaltic pumps very difficult to set a targeted and controlled Förder¬ performance, as exemplified by the elastic see the Schlauchmate¬ respectively used properties rials and its manufacturing tolerances can be explained.
Measuring inside the blood flow by means of, for example rotometers or the like is eliminated from the above 'ones shown, established reasons. The invention is therefore the object of the delivery rate is based on a pumping device to provide for conveying highly sensitive to mechanical stress liquids, by which the mechanical stress is drastically reduced to the conveying liquid, which also largely the generation of abrasion is prevented, and which allows, in deliver accurate, repeatable and controllable doses problems.
The object is achieved by a pump device having the features of claim 1.
The pumping device works on the following principle: a pressure generator, for example a piston pump, is the cavity feed a working liquid or dissipated. Correspondingly, the flexible wall portion of the cavity Arbeits¬ reciprocated. Since the flexible wall part of the elaboration is tshohl space surface in adhesive contact with the fle¬ ble wall portion of the working chamber, this reciprocating motion is transmitted directly to the located in the delivery chamber conveying the liquid, in the sense that suction or pressure movements arise. Via appropriate valves, eg hose clamps on the exhaust and flows into the feed chamber, the suction and exhaust motions carried.
In the embodiment of the pump device according to claim 2, the flexible walls of nested tubular hose parts consist. When according to claim 3, these are superimposed area. An absolutely tight fit of a flexible portion at the other flexible member to allow, should a flexible member according to claim 4, preferably at the same time ductile, be designed.
A further preferred embodiment of the invention consists of the fact that the conveyor chamber and the working cavity are detachably and gas-tightly interconnected.
By an adhesive free of air bubbles Anei nanderl i egen the fle¬ ble parts to ensure each other, they may be executed as randliche seals and possibly with a Absaugvor¬ direction for evacuation. be connected between them befindlicher air.
A preferred arrangement of the schl auchf RMI g shaped flexible parts is given in claim. 7 Entspre¬ accordingly the field of use of the pump device, it may be in part by way of vor¬ to provide a low-deformation pressure gauge in the cavity of the working liquid, or within a flexible member, or a flexible member, and / or a heater.
Since the walls of the delivery chamber and Hydraul i fl üssi gkei tS 'cavities fixed and the respective air-free Anei nanderl i egenden wall parts (permanent and temporary embran) flexible wall parts (permanent and temporary membrane) are flexible and optionally stretchable, the volumes can of feed chamber and elaboration tshohl cavities change only in specified dimensions. For metering the flow rate, it is therefore advantageous to use a pressure generator in the form of a piston pump with adjustable lift amount.
The advantages of the preferred embodiment of the invention according to claims 11 to 14 are given in explanation of FIG. 3 and 4 in the figure description.
The invention based on exemplary embodiment will play with reference to drawings in detail. It shows:
1 shows a cross section through an embodiment of a pumping device.
Figure 2 is a cross section of two connected P-umpvorrichtungen another embodiment, working in opposing phases.
Fig. 3 shows a driving and blood-side flow diagram in applicational case of a blood dosage controllable ultrafiltration with the use of several identical pumping devices with volume difference generating behind a dialyzer;
Fig. 4 is a summary of three Pumpvorri chtungen.zur performing Haemofi 1 trati on the Si ngl e-e- needl OPERATION, wherein the volume difference generation takes place prior to the dialyzer.
The embodiment of a pumping apparatus shown in Fig. 1 comprises a cavity 101 of a hollow cyl see indri flexible wall portion 102 (continuous membrane) and a fixed housing is limited 103rd The hollow cyl i ndri see flexible wall portion 102 is two gegenüberlie¬ constricting walls arranged in a fixed and fluid-tight manner between openings in the housing 103rd The cavity 101 is connected generator via a connecting line 104 with a not shown printer 5, for example a piston pump. In the cavity 101 is a working fluid, by which is transmitted by the pressure generator, for example a piston pump, are periodically generated positive or negative pressure in the cavity 101, thereby correspondingly curved, the flexible wall portion 102 and
IQ is withdrawn and then performs pumping movements. The parts described forming the pump head 105. In the hollow cyl i ndri see wall portion 102 is a hollow cyl i ndri see pumping chamber as a flexible wall portion 106 for the pumped liquid disposed snugly. The pumping chamber 106
15 (exchange membrane) consists of a flexible tube. At one end of the tube is arranged by means of a fitting 107 fixed in the opening of the housing 103 detachably having an inlet and outlet 108,109. The parts 106 to 109 form a replaceable part 110, the disposable part 110
20 of the pump device. The other end of the tube is closed and ver¬ firmly clamped by means of a holding member 112 in the housing 103rd The connector 107 and / or the Halte¬ element 112 may be tapered (see Fig. In Fig. 1, the connector 107), or step-shaped, wherein the breakthroughs
25 in the housing having a corresponding shape. The flexible wall portion 102 and / or the flexible member 106, the pipe of the pump chamber, can serve as a sealing element. There is also the possibility of the inflow into the pumping chamber 113 of the pump chamber 106 at one end and the
30 provide discharge at the other end (not shown).
Preferably, the air between the flexible wall portion 102 and the flexible portion 106 of the feed chamber is removed, so that these two parts surface - optionally generated vacuum - permanently get aufei nanderzul i egen and
35 practically form a double wall which traverses the same paths in lifting movements of the pressure generator, so that the pumping movements of the flexible wall part to be smoothly transmitted to the feed liquid 102nd
Is exerted on all sides pressure via the connection line 104 through the Arbeitsflüssig¬ ness on the tubular flexible wall 102 (continuous membrane), their walls and thus the walls 106 move toward one another and reduce the interior. a liquid located in the space formed by the interior walls 106 of the feed chamber, it is expelled therefrom. For this purpose the two inlets and outlets 108 and 109 are provided which are controlled by valves. At a suction pressure reverse suction in the conveying chamber.
A valve control pressure or a negative pressure can be generated depending on the Kol benbewegung of the pressure generator, which then leads to an ejection and suction of the pumped liquid.
The transmission in Fig.2 dargestell e, another embodiment aufwei¬ embodiment of a pumping device is designed as adjacent double pumpvorri rect, wherein the individual pump means in opposite phases to th processing.
Each pumping device has a cylindrical cavity 201 of a curved, flexible wall forming a lid portion 202 (continuous membrane) and a fixed housing is limited 203rd Here, the housing 203 and the flexible wall portion 202 for both pumping devices is designed in one piece. J.eder cavity 201 is connected generator via a connecting line 204 with a not shown Drucker¬. The flexible wall portion 202 is non-detachably and liquid-tightly connected to the housing 203 in any known manner. The parts 201 to 204 represent a constructional unit, the pump head 205, is. Each flexible wall portion 202 opposite is an approximately correspondingly large flexible wall portion 206 arranged a conveying chamber 213. The flexible wall portion 206 is associated with a liquid-tight manner the conveying cavity 213 final terminal housing 207th Each pumping chamber has an inlet and outlet 208.209. The parts 206 to 209 form a replaceable arene part 210, the "Wegwerftei 1" of the pump device. The disposable part 210 is for example fixed by tailoring 1 ows encrypt or any other known fasteners such on the pump head 205 detachably that the flexible wall portions 202 of the pump head and the flexible wall portions 206 of the disposable part 210 face each other. Here, each of the flexible wall parts can 202.206 directly serve as a seal. Centrally between the two pump devices is carried out an the flexible wall portion 202 also puncture forming channel 211 in the housing 203, which is connected to an unillustrated vacuum pump, so that the air between the elastic wall portions 202 and 206 can be evacuated ,, so that their absolute flat and .dauerndes Anei nanderl ying is ensured, and they are convenient to a wall.
In order to improve the Anei nanderl i egen the two flexible wall parts and to ensure in each case identical volume in the cavities, the flexible walls 102 or 106, 202 or 206, preferably the walls 106 and 206, also highly elastic, which means are made stretchable, while the associated flexible walls are practically not be extensible. The flexible wall portion 206 of the disposable part 210 may be in accordance with the material used by inserting and holding in a circumferential annular groove 212 or in any other manner, for example by gluing or welding. It can not only two, but also according to use several pumping devices, eg 4.6, etc., are summarized. Preferably, the pumping devices are particularly suitable for the transportation of blood. Here, they can be used for example in dialysis and ultrafiltration devices.
Hereinafter, the flexible walls 106 and 206 referred to as exchange membranes and the flexible walls 102 and 202 as continuous membranes.
In Fig. 3, a drive and blood-side flow chart in case of application of a blood dosage controllable ultra-filtration is the use of identical exchange membrane units to volume difference generating behind the dialyzer using the pumping devices described above provides darge.
The main pump 301, a double ply pendulum ol ben, the hydraulic fluid moves pulsatile and from the work area. The deformation caused by the standing membranes 302,303,304, 305 is transferred precisely to the alternating membranes 306,307, 308, and 309th
The two each of four hose valves 310-317 existing closing register 318 and 319 open and close alternately with closing overlap, according to the pump direction of movement, so that an almost continuous flow is ensured through the dialyzer 320 and the machine will no Fi 1tratverl US 't.
An ultrafiltration pump 321, the working phase of work independently from the main pump 301, supplied with an additional volume in each case the working pump chamber which operates in the Di alysatorentnahmephase, so that in the dialyzer occurs a congestion with pressure rise and consequent filtration. The filtration amount corresponds ikflüssigkeitsvolumen the added dose Hydrau. According to the Wegeventi 1 stel 1 ung this volume is withdrawn in the following oppositely ufigen working phase.
The directional control valve 322 has the function of rectifying the continuously with the working phase of the ultrafiltration pump 321 changing flow direction. The directional control valve 323 arranges the suction and pressure volume flows phase cater to the working pump rooms, which are located in the alysatorentnahmephase Tues.
The use of directional control valves is not necessary if the Ul rafiltrationspumpe hauptpu pensynchron l runs and the control of the amount of ultrafiltration via a respective Hubverstell ung occurs.
In Figure 4 the interconnection of three Pumpvorrich-'s obligations represented by difference in volume production before the dialyzer to perform a Haemofi 1trati on in single -Needl e-Betri eb.
Instead of the filtration by means of a Hydraul i kfl üs- si gkei tshi nzudosi augmentation effect, there is also the
Opportunity to bring blood before the dialyzer 412, so that is also a drain jam with pressure increase occurs that causes the amount of filtration.
For this purpose, however, a pump mechanism unit 413 with six supply chambers is required, the conveying chambers 421,422,423 and 424 almost continuously and exactly the same volume to promote the blood in the dialyzer 412 and from the dialyzer 412th The pumping chambers 414 and 415 meter the amount of blood which will the intended
Filtration quantity. (The binding brackets behind the pump chambers indicate the respectively opposite working direction.)
In this application, the blood of the arterial is
Depot removed chamber 416, b * zw. It is conveyed into the venous depot chamber 417 before it is returned to the patient 418th
One operating according to the Si ngl e-e needl system blood pump 419 causes the blood withdrawal from the patient intermittently or return there. In contrast to the conventional operation of a Si ngl e-needl e-system, it is thus possible to achieve near-continuous blood passage through the dialyzer 412 or filter, despite intermittent arrival and conveyed away.
The pump device unit 420 is substantially equal to bau¬ with the pumping chambers 421 to 424 of the Pumpvorrichtungs¬ unit 413. It is used to perform a vol umetri see Haemofi 1trati on. The pumping chambers 425 and 428 meter blood into the dialyzer 412. Since it is not carried away, it corresponds to the intended amount of filtration. The pumping chambers 426 and 427 at the same time promote and volume-identical substitution solution from .einem vessel 42? So that the overall balance of the patient is compensated for in the venous Depotkaramer 417th
Depending on usage, the delivery chambers of the units as a double, quadruple or Sechsfachpumpvorri chtungs- units are combined so that the expense of the introduction is limited to a handle. The increasing or abfüh¬ Governing blood tubing groups are joined together so that the user needs to be connected only as in conventional systems, the dialyzer 404 and 405 and Pati entensei ti gen 406 and 407 tubes. Due to the Gestal¬ processing the blood paths remain free recesses 408,409,410 and 411, by which the control valves for the hose 430 to 437 protrude, are released by either the inflow or the outflow.
Comes the flat membrane embodiment according to Figure 2 for use, it can be dispensed with entirely external blood channels entanglement if a intermediate flange is used which is provided with omission of the movement zones of permanent and temporary membrane. On this intermediate flange, which acts as on 'l agef1 äche for exchange membrane unit, the blood-way interconnection is milled in such a way that the exchange membrane on introduction of vacuum does anformt in these cut-outs. There the blood stream can then be opened or closed from disengaging upward valve wedges. The rigid cover plate 207 here represents the abutment. The four connecting pieces required for the dialyzer or patient hoses can therefore be connected directly to the outlet spigot of the pump cover.
For safety and monitoring reasons, it is erforder¬ Lich to capture the interior of the exchange membrane unit entste¬ Henden pressure. There are therefore dimensionally stable pressure sensors (114 Fig.l; 214 Fig.2) provided. Both in the hollow part as well as at the flat membrane design but the sensor may also be incorporated in the hydraulic fluid space or in the corresponding supply pin. Likewise, he can directly, with exclusion of air, the membrane located at the Wechsel¬ by body performing in the hollow, for example, in the holding member 112 is incorporated, respectively, and wherein the flat membrane design component of Dauermembraπ 202 flush is connected to the exchange membrane 206 with this ,
If it comes to membrane rupture, so breaking the existing
Under pressure suddenly collapsed by suctions the blood via the passage 211 from the pumping chamber 213, the exchange membrane 206 separates from the continuous membrane 202 and thus also from the incorporated into the continuous membrane pressure sensor 214. The pressure sensor detects fluctuations in the short term strong Druckschwan¬ so that with appropriate Si gnal process ing an alarm, and the initiation of the automatic Sicherheitsfunk¬ functions can be initiated.
In certain cases (1 Haemofi trati on, diafiltration, etc.) it may be necessary zugleichen heat loss of blood aus¬. If it is materially a entspre¬-reaching permanent membrane, it may be provided with Widerstandsheizelemen¬ th. Likewise, however, the liquid itself Hydraulik¬ can be heated so that a heat transfer to the permanent and temporary membrane takes place.
When the method adhesive Membrantechni - Blood fine dosing of significant advantages that could not be achieved with conventional blood pump systems under acceptable technical and economic effort result. Essentially, these are:
operating the first blood transportation with Feindosierpräzision for Routine¬.
2. A pump characteristic corresponding to that of the human heart.
3. The extracorporeal blood volume is smaller than when using conventional blood tubing systems.
4. The pumping process is carried out without contact, so that the mechanical strain on the blood is reliably prevented. Hose abrasion is not possible.
5. Kontinui the Membranpassagenf1 tion ußgeschwindigkeit in the dialyzer, in contrast to the intermittent flow using conventional Si ngl e-needl e-systems.
6. Konti nui si augmentation of the blood-side transmembrane pressure and thus reliable transmembrane pressure control to inevitable unlike high
Transmembrane pressure amplitudes using conventional Si ngl e-e needl systems.
7. Vol umetri see Si ngl e-e-needl Betri EBS control. * Zitätsorienti promoting 8. Precise measurement of pressure conditions all the way pump output / cannula or needle / pump outlet and therefore with little effort the possibility shuntkapa ert.
9. Clotti ngüberwachung ago due to the pressure amplitude behavior and after the filter.
10. Precise measurement and control of the respective stroke volume, resulting in the possibility quantitative definition and control Rezi rkul ati onsvol umi na results.
11.Bl utseiti ge withdrawal rate control by
Bl utvol umenhinzudosi enlargement. 1 .B1 utsei ti ge withdrawal rate control by reducing the
Blood volume withdrawal from the dialyzer. 13 Vol umetri see Haemofi 1 concentration.
Patentanprüche
surrounds variable volume which contains a working medium and pumping device for conveying to mechanical stress highly sensitive liquids, characterized by a fixed casing (103; 203) having a flexible Wand¬ part;; and having a sealed cavity (102 202) (201 101) via a connection line (104; 204) is connected to a pressure generator, and by a liquid-tight with inlets and outlets (108, 109; 208.209) in a liquid provided conveying chamber for the Förder¬, the at least one flexible wall portion (106; 206), wherein the flexible walls (106; 206) of the housing and of the conveyor chamber are each arranged lying gegenüber¬ ange¬ engageable in flat touching contact.
2. Pump device according to claim 1, characterized in that the flexible members (102; 106) of the housing (103) and the feed chamber each hollow cyl i ndri see are executed and the delivery chamber within the hollow cyl i ndri see part (102) of the housing (103) is arranged.
3. Pump device according to claim 1, characterized in that the flexible members (202; 206) of the housing (203) and of the conveyor chamber are made flat.
4. Pumping device according to one of claims 1 to 3, characterized in that the flexible parts (106; 206) are also extensible to the delivery chamber.
5. Pumping device according to one of claims 1 to 4, characterized in that the pressure generator connected to the pump head (105; 205) gas-tightly and releasably connected to the disposable part (110; 210) is connected.
Pumping device according to one of claims 1 to 5, characterized in that the flexible parts (102 and / or 106; 202 and / or 206) are designed as mutual luft¬ tight seals, the clearance between them via a channel (211) to a Absaug¬ is device connected.
Pumping device according to claim 5 or 6, characterized in that the pump head (105) through two openings in the housing (102) is guided to the outside,
8. Pumping device according to one of claims 1 to 7, characterized in that a pressure sensor and a heater are appropriate, provided gegebe¬.
9. Pumping device according to one of claims 1 to 8, characterized in that the pressure generator is a piston pump with adjustable lift amount.
10. Pumpvorri rect according to one of claims 1 to 9, characterized in that the working medium is a liquid uid i st.
11.Pumpvorrichtung according to one of claims 1 to 10, characterized in that the conveying fluid is blood i st.
12. Pumping device according to one of claims 1 to 11, characterized in that a plurality Pu pvorrichtungeπ arranged and are supplied by pressure generators with operating liquid that simultaneously by a number of pumping devices, the same - ^ o volume amount sucked at the conveying fluid and by the same number of pumping devices is released again.
13. Pump device according to one of claims 1 to 12, 15 characterized in that the inflows and outflows
, (108, 109; 208.209) via controllable Venti 1 formations with a blood treatment apparatus, as connected, for example for dialysis and / or ultrafiltration.
14. Pumpvorri rect according to any one of claims 1 to 13, characterized in that at least one additional
Piston pump for dosing a Störvolumens before or after a blood treatment device for the drive
liquid is provided 25th
15. Pumpvorri rect according to any one of claims 1 to 13, characterized in that at least one additional piston pump and at least one additional delivery chamber
30 are provided for metering a Störvolumens before or after a blood treatment apparatus for the conveying liquid.
PCT/EP1985/000393 1984-08-04 1985-08-05 Device for pumping liquids which are highly sensitive to mechanical strains WO1986001115A1 (en)
DEP3428828.7 1984-08-04
DE3428828A DE3428828C2 (en) 1984-08-04 1984-08-04
AT85904103T AT52035T (en) 1984-08-04 1985-08-05 Pump device for conveying to mechanical stress highly sensitive liquids.
DE19853577186 DE3577186D1 (en) 1984-08-04 1985-08-05 Pump device for conveying to mechanical stress highly sensitive liquids.
WO1986001115A1 true WO1986001115A1 (en) 1986-02-27
ID=6242381
PCT/EP1985/000393 WO1986001115A1 (en) 1984-08-04 1985-08-05 Device for pumping liquids which are highly sensitive to mechanical strains
EP (1) EP0191071B1 (en)
AU (1) AU4723485A (en)
DE (1) DE3428828C2 (en)
WO (1) WO1986001115A1 (en)
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WO2009017487A1 (en) 2007-08-01 2009-02-05 Cardinal Health 303, Inc. Fluid pump with disposable component
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DE2343042A1 (en) * 1973-08-25 1975-02-27 Otto Tuchenhagen Piston-operated flexible hose diaphragm pump - has two coaxial hoses with intermediate space communicating with outside
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DE3210240A1 (en) * 1982-03-20 1983-10-06 Heinz M Naegel Diaphragm displacement pump
1984-08-04 DE DE3428828A patent/DE3428828C2/de not_active Expired
1985-08-05 WO PCT/EP1985/000393 patent/WO1986001115A1/en active IP Right Grant
1985-08-05 AU AU47234/85A patent/AU4723485A/en not_active Abandoned
1985-08-05 EP EP85904103A patent/EP0191071B1/en not_active Expired - Lifetime
FR2710847A1 (en) * 1993-10-06 1995-04-14 Chatel Didier Device forming artificial cÓoeur.
EP2180911A1 (en) * 2007-08-01 2010-05-05 CareFusion 303, Inc. Fluid pump with disposable component
EP2180911A4 (en) * 2007-08-01 2013-12-25 Carefusion 303 Inc Fluid pump with disposable component
US10076604B2 (en) 2012-12-24 2018-09-18 B. Braun Melsungen Ag Pump for medical purposes
EP0191071B1 (en) 1990-04-18
EP0191071A1 (en) 1986-08-20
DE3428828A1 (en) 1986-02-13
AU4723485A (en) 1986-03-07
CA1282012C (en) 1991-03-26 Apparatus for use with fluid flow transfer device
EP2237814B1 (en) 2019-03-06 Manifold for conducting hemodialysis and hemofiltration
JP4537198B2 (en) 2010-09-01 Apparatus for handling a liquid for medical
US8968232B2 (en) 2015-03-03 Heat exchange systems, devices and methods
US9393397B2 (en) 2016-07-19 Diaphragm pressure pod for medical fluids
US9694125B2 (en) 2017-07-04 Medical fluid cassettes and related systems and methods
Designated state(s): AU BG BR DK FI HU JP KP KR NO RO SU US
1986-04-03 WWE Wipo information: entry into national phase
Ref document number: 1985904103
1986-08-20 WWP Wipo information: published in national office
1990-04-18 WWG Wipo information: grant in national office