Source: https://patents.google.com/patent/US8584669B2/en
Timestamp: 2019-06-24 12:19:26
Document Index: 363625283

Matched Legal Cases: ['§271', 'art 26', 'art 15', 'art 14', 'art 15', 'art 14', 'art 15', 'art 14', 'art 15', 'art 14', 'art 14', 'art 26', 'arts 14', 'art 14']

US8584669B2 - Inhaler - Google Patents
US8584669B2
US8584669B2 US12/296,560 US29656007A US8584669B2 US 8584669 B2 US8584669 B2 US 8584669B2 US 29656007 A US29656007 A US 29656007A US 8584669 B2 US8584669 B2 US 8584669B2
US12/296,560
US20090194105A1 (en
2006-04-13 Priority to EP06007767A priority Critical patent/EP1844805A1/en
2006-04-13 Priority to EP06007767.4 priority
2006-04-13 Priority to EP06007767 priority
2007-04-11 Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
2007-04-11 Priority to PCT/EP2007/003208 priority patent/WO2007118648A1/en
2009-01-22 Assigned to BOEHRINGER INGELHEIM INTERNATIONAL GMBH reassignment BOEHRINGER INGELHEIM INTERNATIONAL GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HOCHRAINER, DIETER, DWORZAK, CHRISTOPH, KLOPFENSTEIN, ANDRE, LANCI, ANTONINO, MAST, MARKUS, MOCK, ELMAR, ECKERT, JOSEF, BESSELER, JENS, MOSER, ACHIM, KUNZE, HUBERT, THOEMMES, RALF, WUTTKE, GILBERT, KLADDERS, HEINRICH
2009-08-06 Publication of US20090194105A1 publication Critical patent/US20090194105A1/en
2013-11-19 Publication of US8584669B2 publication Critical patent/US8584669B2/en
This application is the national phase entry under 35 U.S.C. §271 of International Application No. PCT/EP2007/003208, filed Apr. 11, 2007, which claims priority to European Application No. EP 06007767.4, filed Apr. 13, 2006, each of which is hereby incorporated by reference in its entirety.
FIG. 3 b shows a schematic view of the opening of the carrier according to FIG. 3 a;
FIG. 3 c is a schematic section of a detail from FIG. 3 b;
FIG. 3 d is a schematic view of another embodiment;
FIG. 3 f is a schematic section through a detail of FIG. 3 e;
FIG. 3 g is a schematic section of a detail of another embodiment;
FIG. 4 b is a schematic section through a detail of the inhaler according to FIG. 4 a;
FIG. 5 a is a schematic view of a carrier of the inhaler according to another embodiment;
FIG. 5 b is a schematic magnification of FIG. 5 a;
FIG. 5 c is a schematic section or side view of the inhaler with the carrier according to FIG. 5 a;
FIG. 6 a is a schematic, partially cut away view of the inhaler according to another embodiment;
FIG. 6 b is a schematic section through a detail of the inhaler according to FIG. 6 a;
FIG. 6 c is a schematic lateral functional view of the inhaler according to FIG. 6 a;
FIG. 7 a is a schematic section through the inhaler according to another embodiment in a position of non-use;
FIG. 8 b is a schematic section through the inhaler according to FIG. 8 a;
FIG. 8 c is another schematic section through the inhaler according to FIG. 8 a;
FIG. 9 is a schematic section through the inhaler according to another embodiment;
FIG. 14 d is a perspective view of the open inhaler according to FIG. 14 c;
FIG. 15 a is a schematic view of a filling device and the capsule chamber of the inhaler according to FIG. 14 a with the capsule chamber open;
FIG. 15 c is a schematic view of a part of the capsule chamber of the opening device or the capsule chamber of the inhaler according to FIG. 14 a;
FIG. 16 a is a schematic detailed section through the inhaler according to FIG. 14 a with the capsule chamber open;
FIG. 26 is a detailed, section-like functional view of the inhaler according to FIG. 21 after rotation through 90°;
FIG. 38 b shows a schematic section through a capsule chamber of the inhaler according to FIG. 38 a;
FIG. 38 c shows a detailed section of the inhaler according to FIG. 38 a;
FIG. 39 shows a schematic sectional structure of a reservoir of the inhaler according to another embodiment;
Suitable plastic materials for the capsules 3 are any pharmaceutically acceptable plastics which can be processed by injection or blow moulding and deep drawing by thermoforming and/or plastics which do not require a mould release agent in order to process them to form the capsule cap or capsule body, as the mould release agent may cause the contents to stick to the capsule wall. The plastic should also not have any marked adhesion to pharmaceutical chemical substances, particularly particles of a size intended for the lungs. The preferred Shore hardness D of the materials is preferably between 10 and 85, preferably between 55 and 75, most preferably between 60 and 70. The material should also be such that a plastic capsule 3 will withstand a force of preferably up to 20 N along its longitudinal axes. Moreover, the wall of the capsule 3 should have a permeability to water vapour of less than 1.3×10−14 kg/(m2s Pa), preferably 1.5×10−16 kg/(m2s Pa). The melt viscosity MFR (melt flow rate) is preferably between 40 and 65 g/10 minutes, preferably 45-49 g/10 minutes and most preferably 52 g/10 minutes.
FIG. 3 d is a schematic view of a detail of another embodiment. The cover 12 is not wound on to the second roller 18 b in this case, but preferably laid on a ring 18 c rotating in the opposite direction, via the first roller 18 a.
FIG. 3 e illustrates another embodiment. Here, the cover 12 is preferably formed from individual pieces or segments 12 a which can be pulled away by means of an opening element 18 d. The opening element 18 d is preferably coupled to the opening device 5 such that when the piercing elements 6 are withdrawn the respective capsule chamber 4 is opened and thus made ready for inhalation.
The schematic section in FIG. 3 f illustrates the principle. The opening element 18 d is preferably constructed like a hook and preferably hooks into an optional recess and opening in the respective cover portion 12 a which is to be pulled off first. In the state shown in FIG. 3 e—in the course of the movement indicated by the arrow in FIG. 3 f—the respective cover portion 12 a is preferably pulled radially inwards and in this way the associated capsule chamber 4 is opened. This state is shown in FIG. 3 f. At the latest during the movement of the opening element 18 b back into its starting position shown in FIG. 3 e the pulled-off cover portion 12 a can become detached from the opening element 18 d or its hook and preferably drop into or be placed into an optional catching container 18 e or the like shown in FIG. 3 f.
FIG. 3 g shows another embodiment in a comparable section. Here, the opening element 18 d is in particular in the shape of a shovel. Preferably the opening element 18 d engages with two shovel-like ends in preferably radial grooves 18 f in the carrier 11 laterally underneath the respective cover portion 12 a and peels it off, particularly from the outside. The cover portions 12 a that are peeled off or pulled off are preferably in turn received by the collecting container 18 e.
If necessary the cover 12 may also be made in one piece. In this case it is opened, preferably by a suitable construction of the opening element 18 d, in such a way that the cover 12 is cut or otherwise separated into individual cover portions 12 a, provided that the cover 12 is not coiled, in particular, or otherwise collected as a continuous band, strip or the like. To assist with the formation of individual or separable cover portions 12 a the cover 12 is if necessary slotted, perforated and/or provided with other frangible points or the like. Preferably, separate or distinct covers 12 or cover portions 12 a are provided for the inlet side on the one hand and the outlet side, on the other hand, of the capsule chambers 4. However, it is theoretically also possible to use a common cover 12 or common cover portions 12 a which cover at least the respective inlet 8 and outlet 9 of a capsule chamber 4.
FIGS. 5 a to 5 c show another embodiment. FIG. 5 a shows in a perspective view the carrier 11 with radially aligned capsules 3 and capsule chambers 4 which are arranged or offset from one another alternately in two axial planes. Preferably, each capsule chamber 4 is associated with an opening device 5, which is in particular in the form of a lever or bar, and which is constructed in particular similarly to the opening device 5 shown in FIGS. 4 a and b. To allow the overall height to be kept low in the axial direction the carrier 4 preferably has radial grooves 18 f between the capsule chambers 4, on both of the flat or end faces, into which the opening devices 5 extend, as shown in the magnified detail in FIG. 5 b.
The piercing or opening of the respective capsule chamber 4 preferably takes place in the axial direction. The individual opening devices 5 are preferably actuated by means of a cam, slide 18 g or the like. It is particularly preferable for this to be arranged on the mouthpiece 10 or formed thereby, as can be seen from the schematic section in FIG. 5 c.
The mouthpiece 10 can be radially extended and in particular rotated through 180°. With the rotary movement, the preferably annular carrier 11 is rotated further by one position, i.e. to the next capsule chamber 4. In addition the flow channel or outlet 9 formed by the mouthpiece is moved by the rotation into the corresponding axial plane of the capsule chamber 4 intended for the next inhalation. The radial movement of the mouthpiece 10 preferably brings about the, in particular, automatic actuation or movement of the opening device 5, for example by the engagement of a projection 18 h into the slide 18 g which preferably extends radially. The piercing or opening may if necessary take place while the mouthpiece 10 is being pulled out or pushed in.
When the mouthpiece 10 is rotated through 180°, the carriers 11 move or rotate alternately. At the same time the two covers 12 are peeled or pulled off at the circumference, preferably coiled, as explained previously. By means of a cam, slide 18 g or the like, particularly on the mouthpiece 10, the preferably central or shared opening device 5 which is arranged in particular between the two carriers 11 is actuated so as to open or pierce the capsules 3 and the inlets 8 of the capsule chambers 4 alternately in the upper and lower carrier 11.
The mouthpiece 10 may if required be capable of pivoting or folding through 90° or even up to 270°. Preferably the mouthpiece 10 latches both in its position of use and in its storage position.
FIG. 13 shows, in a detailed schematic section, one possible construction of the inhaler 1. The capsule chambers 4 or guide elements 21 are preferably guided at the top and/or bottom by the guide 20, particularly via the engagement elements 21 a.
In the embodiment shown the capsule chambers 4 can be removed from the guide elements 21 for inhalation. FIG. 13 shows a capsule chamber 4 in the inhaling position immediately below the mouthpiece 10 with the outlet 9 or mouthpiece 10 adjacent to the capsule chamber 4. This capsule chamber 4 has been removed, particularly by the opening device 5 or some other mechanism, from the associated guide element 21, which is shown on the left hand side in the embodiment in FIG. 13, so as to open the capsule chamber 4 on the inlet side and outlet side, open the capsule 3 contained in the capsule chamber 4, particularly by piercing, and/or connect the capsule chamber 4 to the corresponding air or gas guide on the inlet side and/or outlet side.
In particular, the following sequence or following operation is possible. The mouthpiece 10 is rotated through 90°, for example, with the covering cap closed (not shown). As a result the capsule chambers 4 or guide elements 21 are moved on by one position. As the mouthpiece 10 rotates further, the next capsule chamber 4 is moved to a position under the mouthpiece 10, particularly out of the associated guide element 21, and the capsule 3 contained therein is opened or pierced. Preferably, the covering cap (not shown) cannot be flipped upwards to expose the mouthpiece 10 until this moment and only after the mouthpiece 10 has reached this rotational position, e.g. a rotation of 180° relative to the initial position.
Then the device 25 conveys the capsule 3 received into the capsule chamber 4, particularly by corresponding displacement or other movement of the capsule chamber part 26. In this way the capsule chamber 4 is filled with the capsule 3 and closed, as shown in FIG. 14 b.
The opening, particularly piercing, of the capsule 3 may be carried out if desired by means of the device 25, a separate opening device 5, not shown here, or other suitable means. In particular, the opening may take place directly as the capsule 3 is conveyed or transferred to or into the capsule chamber 4 or only after it has reached the capsule chamber 4, i.e. only after the capsule chamber 4 has been closed. In the latter case it is also possible to open the capsule 3 only immediately before inhalation, for example by suitable actuation of the mouthpiece 10, a covering cap (not shown) associated with the mouthpiece 10, or the like.
After the emptying of the capsule chamber 4 indicated in FIG. 18 this chamber is filled with the next capsule 3. Preferably, for this purpose, the next capsule 3 is pushed or inserted by means of the conveying element 25 a into the capsule chamber 4 which is in the filling position (the lower one in FIG. 18). In the embodiment shown the cleaning device is thus preferably formed by the device 25 or its conveying element 25 a.
In the case of the pivoting device 29, if three capsule chambers 4 are formed, for example, there is the possibility that the capsule chambers 4 can occupy three positions alternately, namely the filling position, the inhaling position and an (additional) cleaning position. By suitable further rotation each capsule chamber 4 is moved from one position to the next. In the cleaning position, using the cleaning device already mentioned, the used capsule 3 can be removed from the respective capsule chamber 4 and the capsule chamber 4 can be cleaned.
FIGS. 21 and 22 show another embodiment of the proposed inhaler 1. In FIG. 21 the inhaler 1 is in the transporting state of inhalation state. FIG. 22 shows an intermediate phase in which the upper housing part 15 has been rotated in particular through 90° relative to the lower housing part 14 and is preferably axially raised at the same time. Generally, the upper housing part 15 and lower housing part 14 may be any, preferably external parts of the inhaler 1. Preferably, however, the upper part 15 engages over or around the lower part 14 in the manner of a pot, or vice versa.
The rotary movement or rotation of the upper housing part 15 relative to the lower housing part 14 is continued. FIG. 26 shows a state in which the control sleeve 35 has already been rotated through about 90° or 180° relative to the lower housing part 14. The push rod 39 or the part 26 has been fully retracted from the receptacle 33. The empty capsule 3 has been moved back out of the capsule chamber 4 into the receptacle 33. The piercing elements 6 have again been fully withdrawn from the following capsule 3 and receptacle 33.
In the embodiment shown, actuation is very simple. In particular, all that is required is to rotate the parts 14, 15 relative to one another. Preferably, in the embodiment shown, rotation through 180° or 360° is necessary in order to run through the procedure described above, i.e. to allow the next dose to be delivered.
FIG. 28 schematically shows the structure of another embodiment of the proposed inhaler 1. The inhaler 1 has a plurality of capsule chambers 4 which are formed by the conveying device 34 or a drive wheel 41. The capsules 3 which are preferably in strip form or loose (not shown) are transported onwards by the rotation of the drive wheel 41 and are accommodated one after the other in the capsule chambers 4 which are preferably initially open at the side. For example, the drive wheel 41 is rotated in steps of 90° (in the embodiment shown, four capsule chambers 4 are formed on the drive wheel 41, arranged uniformly at 90° intervals). Thus, one after the other, one of the capsule chambers 4 containing a capsule 3 is placed or moved into the inhaling position located in the corner of the housing, for example, and is closed off laterally, in particular, by a wall such as the lower housing part 14.
Once the covering cap 43 has opened far enough, for example more than 90° and in particular more than 130°, and accordingly the next capsule 3 has been opened and conveyed into the capsule chamber 4 and the capsule chamber 4 has been closed, the mouthpiece 10 can be flipped outwards and inhalation may take place. This condition is illustrated in FIG. 30.
FIG. 38 a shows another embodiment of the inhaler 1 with a receiving chamber 23 or capsule reservoir 31 in a schematic section. Each capsule 3 is pre-packaged in a capsule chamber 4, as shown in section in FIG. 38 b.
The capsule chambers 4 with the capsules 3 are in particular contained in a meandering or other configuration in the inhaler 1 or receiving chamber 23 or reservoir 31 and can preferably be advanced by means of at least one and in particular for transporting or driving wheels 41 individually to the mouthpiece 10.
In the embodiment according to FIG. 42 the capsule reservoir 31 receives the capsules 3, preferably in an alignment at right angles to the longitudinal direction of the capsule reservoir 31. The capsules 3 are arranged either in two rows or stacks in the axial direction of the capsule reservoir 31 or along a coil or helical line in the capsule reservoir 31. The gate 54 comprises, in particular, only one opening 55. As the shutter 57 is rotated or turned stepwise, so that its opening 55 is brought into alignment with the opening 55 in the gate 54, the capsules 3 are preferably expelled singly. In particular, one capsule 3 can be expelled in a specific rotational position of the shutter 57. In the opposite position of rotation or the position shown in FIG. 42 which is rotated through 180°, in particular, the capsule reservoir 31 is preferably tightly sealed, particularly to protect the capsules from excessive climatic fluctuations and/or prevent the capsules 3 from drying out too much.
(S)-fluoromethyl 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-1,1-hydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carbothionate
(S)-(2-oxo-tetrahydro-furan-3S-yl)6,9-difluoro-1,1-hydroxy-16-methyl-3-oxo-17-propionyloxy-androsta-1,4-diene-17-carbothionate,
4-[(3-ethynyl-phenyl)amino]-6-[1-(tetrahydropyran-4-yloxy]-7-methoxy-quinazoline
6a additional piercing element
12a cover portion
18a first roller
18b second roller
18c ring
18d opening element
18e collecting container
18f groove
18g slide
18i cam
20a track
21a engaging element
25a conveying element
29a sun wheel
29b gear wheel
47 ring/segment
49a spike
51 gear rim
1. An inhaler (1) for the inhalation of a formulation (2) from capsules (3), each containing one dose of the formulation (2), wherein the inhaler (1) comprises a plurality of capsule chambers (4) containing respective capsules (3) in order to empty them during inhalation, wherein each of the capsule chambers (4) contains a respective one of the capsules (3), each capsule chamber (4) and capsule (3) can be used only once, and the capsule chambers (4) are arranged in a ring such that the capsule chambers (4) and the capsules (3) are aligned radially with respect to a central point.
2. The inhaler according to claim 1, further comprising a first ring of the capsule chambers (4) and the capsules (3) that aligned radially with respect to a first central point, and a second ring of the capsule chambers (4) and the capsules (3) that aligned radially with respect to a second central point, wherein the first and second rings are disposed one atop the other.
3. The inhaler according to claim 1, further comprising at least one annular carrier (11) within which the capsule chambers (4) and the capsules (3) are disposed.
4. The inhaler according to claim 1, wherein the capsule chambers (4) include an inlet side and an outlet side, which are closed off by a shared cover (12) at least on the inlet and/or outlet side, wherein said shared cover (12) is selected from foil, cover portions (12 a), sleeves and stoppers (61).
5. The inhaler according to claim 4, wherein the cover (12) or cover portions (12 a) is laminated on the carrier (11).
6. The inhaler according to claim 4, wherein the cover (12) or cover portions (12 a) is used to cover respective piercing openings (7) extending in the respective capsule chambers (4).
7. The inhaler according to claim 4, wherein the capsule chambers (4) can be opened individually through the cover (12) or cover portions (12 a), wherein said cover (12) or cover portions (12 a) is pulled off, peeled off, unwound, wound up, pierced or cut.
8. The inhaler according to claim 7, wherein said cover (12) or cover portions (12 a) is pulled off, peeled off, unwound, or wound up via at least one roller (18 a, 18 b).
9. The inhaler according to claim 7, wherein said cover (12) or cover portions (12 a) is pulled off or peeled via a hook- or shovel-like opening element (18 d).
10. The inhaler according to claim 7, wherein the capsule chambers (4) and the capsules (3) are closed in fluid-tight or gas-tight manner and/or can be opened individually.
11. The inhaler according to claim 1, wherein the capsule chamber (4) is of elongate construction and air can flow therethrough in a longitudinal direction thereof in order to empty the respective capsule (3) and/or expel the respective dose of the formulation (2).
12. The inhaler according to claim 1, wherein the capsule chambers (4) and the capsules (3) are movable for emptying after the respective capsule (3) has been opened.
13. The inhaler according to claim 1, wherein the capsules (3) can be moved back and forth or set oscillating or vibrating in the respective capsule chamber (4) in order to empty them.
14. The inhaler according to claim 1, further comprising an opening device (5) for opening the respective capsules (3) laterally, radially axially or at an end face thereof, via piercing the capsule (3) through the capsule chamber (4).
15. The inhaler according to claim 14, wherein the capsule chamber (4) has at least one re-sealable opening (7) therethrough for receiving a piercing element (6) that pierces the capsule (3), the opening (7) being re-sealable by means of a cover (12), a cover portion (12 a), a septum or a spring-loaded or elastic cover element.
16. An inhaler (1) for the inhalation of a formulation (2) from capsules (3), each containing one dose of the formulation (2), wherein the inhaler (1) comprises a plurality of capsule chambers (4) for receiving respective capsules (3) in order to empty them during inhalation, wherein each of the capsule chambers (4) contains a respective one of the capsules (3), each capsule chamber (4) and capsule (3) can be used only once, and the capsule chambers (4) are arranged in a ring such that the capsule chambers (4) and the capsules (3) are aligned radially with respect to a central point, wherein the capsule chambers (4) include an inlet side and an outlet side, which are closed off by a shared cover (12) at least on the inlet and/or outlet side, wherein said shared cover (12) is selected from foil, cover portions (12 a), sleeves and stoppers (61), and wherein the cover (12) or cover portions (12 a) is laminated on the carrier (11).
17. An inhaler (1) for the inhalation of a formulation (2) from capsules (3), each containing one dose of the formulation (2), wherein the inhaler (1) comprises:
a plurality of capsule chambers (4) for receiving respective capsules (3) in order to empty them during inhalation, wherein each of the capsule chambers (4) contains a respective one of the capsules (3), each capsule chamber (4) and capsule (3) can be used only once, and the capsule chambers (4) are arranged in a ring such that the capsule chambers (4) and the capsules (3) are aligned radially with respect to a central point; and
an opening device (5) for opening the respective capsules (3) laterally, radially axially or at an end face thereof, via piercing the capsule (3) through the capsule chamber (4).
US12/296,560 2006-04-13 2007-04-11 Inhaler Active 2030-10-16 US8584669B2 (en)
EP06007767A EP1844805A1 (en) 2006-04-13 2006-04-13 Inhaler
EP06007767.4 2006-04-13
EP06007767 2006-04-13
PCT/EP2007/003208 WO2007118648A1 (en) 2006-04-13 2007-04-11 Inhaler
US20090194105A1 US20090194105A1 (en) 2009-08-06
US8584669B2 true US8584669B2 (en) 2013-11-19
ID=36693201
US12/296,560 Active 2030-10-16 US8584669B2 (en) 2006-04-13 2007-04-11 Inhaler
US (1) US8584669B2 (en)
EP (2) EP1844805A1 (en)
JP (3) JP5581691B2 (en)
CA (1) CA2648964C (en)
WO (1) WO2007118648A1 (en)
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2006-04-13 EP EP06007767A patent/EP1844805A1/en not_active Withdrawn
2007-04-11 CA CA2648964A patent/CA2648964C/en active Active
2007-04-11 EP EP07724149A patent/EP2004264A1/en not_active Withdrawn
2007-04-11 WO PCT/EP2007/003208 patent/WO2007118648A1/en active Application Filing
2007-04-11 JP JP2009504635A patent/JP5581691B2/en active Active
2007-04-11 US US12/296,560 patent/US8584669B2/en active Active
2013-05-20 JP JP2013106171A patent/JP5831949B2/en active Active
2015-04-01 JP JP2015074937A patent/JP6056110B2/en active Active
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JP5581691B2 (en) 2014-09-03
CA2648964C (en) 2014-06-17
CA2648964A1 (en) 2007-10-25
JP6056110B2 (en) 2017-01-11
EP2004264A1 (en) 2008-12-24
WO2007118648A1 (en) 2007-10-25
JP5831949B2 (en) 2015-12-09
JP2009533111A (en) 2009-09-17
JP2013154237A (en) 2013-08-15
US20090194105A1 (en) 2009-08-06
JP2015120074A (en) 2015-07-02
EP1844805A1 (en) 2007-10-17
KR20080068924A (en) 2008-07-24 Needle for puncturing powder capsules for inhalation
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BESSELER, JENS;KUNZE, HUBERT;MOSER, ACHIM;AND OTHERS;REEL/FRAME:022138/0528;SIGNING DATES FROM 20081030 TO 20081218
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BESSELER, JENS;KUNZE, HUBERT;MOSER, ACHIM;AND OTHERS;SIGNING DATES FROM 20081030 TO 20081218;REEL/FRAME:022138/0528