Source: https://patents.google.com/patent/EP2872198B1/en
Timestamp: 2019-05-19 23:44:11
Document Index: 194880042

Matched Legal Cases: ['art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100', 'art 2100']

EP2872198B1 - Dispense interface for an ejection device - Google Patents
EP2872198B1
EP2872198B1 EP13735039.3A EP13735039A EP2872198B1 EP 2872198 B1 EP2872198 B1 EP 2872198B1 EP 13735039 A EP13735039 A EP 13735039A EP 2872198 B1 EP2872198 B1 EP 2872198B1
EP13735039.3A
EP2872198A1 (en
2012-07-11 Priority to EP12175975 priority Critical
2013-07-10 Priority to EP13735039.3A priority patent/EP2872198B1/en
2013-07-10 Priority to PCT/EP2013/064631 priority patent/WO2014009443A1/en
2015-05-20 Publication of EP2872198A1 publication Critical patent/EP2872198A1/en
2017-10-18 Publication of EP2872198B1 publication Critical patent/EP2872198B1/en
This causes requirements for the material and design of the dispense interface to be fulfilled. Since the drug agents from the first and/or the second reservoir remain inside the dispense interface after a dispense procedure, a compatibility of the dispense interface being in contact with the drug agents needs be to provided. No harmful substances must diffuse into the drug agents, since these would then be delivered to the patient with the next delivery procedure. Hence a biocompatibility is required, which guarantees that either no or negligible amounts of substances can diffuse into drug agents or are set free into the liquid. Furthermore, if the dispense interface remains attached to the drug delivery device the different drug agents also start to diffuse into each other over time. A cross-contamination of the drug agents from one reservoir into the other reservoir needs to be prevented for the above mentioned reasons of stability, compromised therapeutic performance and toxicology, for example.
In light of the aforementioned, the invention inter-alia faces the technical problem of providing a simple dispense interface for an ejection device that is easy to manufacture. Prior art dispensing interfaces are disclosed in WO 2012/072559 A1 and WO 94/22507 . The present invention is as set out in the appended claims.
According to a first aspect of the invention, a dispense interface for a an ejection device comprises at least two inlets, at least one outlet, a body part, and a fluid channel arrangement within the body part configured to provide fluid communication between the at least two inlets and the at least one outlet; an ullage formed as a recess in a side of the integral body part; a rotatable flap positioned within the ullage and configured to rotate between: a first position wherein the flap seals a first of the said inlets and allows fluid to flow from a second of the said inlets to the outlet; and, a second position wherein the flap seals the second said inlet and allows fluid to flow from the first said inlet to the outlet; wherein each of the at least two inlets is formed from a tubelike fluid element; wherein each of the tubelike fluid elements is molded into the body part; and wherein each of the tubelike fluid elements provides at least a part of the fluid channel arrangement within said body part; and wherein each of said tubelike fluid elements is at least partially curved.
The fluid channel arrangement within the body part may comprise one or more connected fluid channels, which inter alia are at least partially provided by the tubelike fluid elements. The diameter of the fluid channels may be between 0.01 mm and 10mm. In particular, the diameter of the fluid channels may be between 0.1 mm and 1 mm, for instance about 0.3mm. The ratio between the length of the fluid channel arrangement and the diameter of the fluid channels (length:diameter ratio) may be substantially large, for instance between 10:1 and 1000:1. In particular, the length:diameter ratio may be between 20:1 and 100:1, for instance about 33:1 or 66:1. The length of the fluid channel arrangement may preferably describe the longest fluid path of the fluid channel arrangement. Since the tubelike fluid elements provide at least a part of the fluid channel arrangement, the tubelike fluid elements may comprise the same dimensions as set out above.
For instance, use of an open-and-shut tool reduces the need for fragile core pins. This also allows for relatively complex and tight tolerance geometry without complex tooling. The molding of key assembly snap features on the same component, such as an outer protrusion on the body part, may also help reduce tolerance stack-ups and also tends to allow for smaller fluid grooves (e.g. needle wells) and therefore smaller ullage. Alternative also the in gas pressure molding process forms a good surface inside the ullage area of the body part.
For instance, the body part may be a plastic part from a thermoplastic or a thermosetting material. Polymer materials may be used in injection molding of the body part. Polymer materials are typically biocompatible. For instance, COP (cyclo-olefin polymer) materials may be used in injection molding of the body part. COP materials have a high biocompatibility. For instance, COP materials have little to no extractables and most COP materialy can undergo sterilization by gamma radiation, steam and/or ethylene oxide. Other materials such as PP (poly-propylene) or HDPE (high density poly-ethylene) or other less expensive materials may be used, too. Especially, the body part of a single use dispense interface may be made from such a material, as the contact time with the medicament is rather short (only the time from priming the device until the injection is completed).
The dispense interface of the first aspect of the invention thus allows a simple manufacturing of the dispense interface, in particular in a single manufacturing step. Furthermore, the count and complexity of the assembly parts of the dispense interface is reduced. The invention is therefore inter alia advantageous to allow a simple manufacturing and/or assembly of a dispense interface. Also, it allows a cost-effective manufacturing assembly of a disposable dispense interface (e.g. a single use dispense interface). Particularly, potential problems of material compatibility, absorption and cross contamination between the fluids (e.g. drugs) and the polymer material may be overcome by providing a dispense interface wherein each of the tubelike fluid elements provides at least a part of the fluid channel arrangement and/or - for a single use dispense interface - by a short contact time. In this way, also a reduction in the cost of goods can be achieved.
The ullage may also comprise a metal chamber, particularly a steel or stainless steel chamber. The metal chamber may be an insert inserted into the ullage or the metal chamber may be molded into the body part. The metal chamber may at least partially be inserted (e.g. potted/over-molded/mounted) into the body part. For instance, the metal chamber may at least partially be potted/over-molded when the body part is (e.g. injection) molded. For instance, the metal chamber may at least partially be glued/mounted in a separate step after the body part has been (injection) molded. For instance, the metal chamber may be an integral part of the dispense interface. According to an exemplary embodiment of the dispense interface of the first aspect of the invention, the dispense interface further comprises a valve arrangement, in the ullage, configured to control a fluid flow from the at least two inlets to the at least one outlet via the fluid channel arrangement. Such a valve arrangement may preferably be configured to prevent cross contamination of fluids contained in separate fluid reservoirs of the ejection device. A preferred valve arrangement may also be configured so as to prevent back flow. An example according to the invention is a rotating flap valve.
According to an exemplary embodiment of the dispense interface of the first aspect of the invention, the dispense interface further comprises a film layer; wherein the film layer is bonded to the body part to seal the fluid channel arrangement, in particular the ullage, of the body part. For instance, the film layer may be a metal foil, a polymer film, or a bio-polymer film. The film layer may in particular be a foil or a laminate consisting of two or more layers of different or the same material. For instance, the thickness of the film layer may be 1 µm to 1 mm, in particular 5 µm to 500 µm. For the used materials, a combination of polyamide (PA) and polypropylene (PP) can be used, as PP is biocompatible.
For instance, the film layer may be a polymer material, which is biocompatible. For instance, COP (cyclo-olefin polymer) materials may be used for the film layer. COP materials have a high biocompatibility. For instance, COP materials have little to no extractables and most COP materialy can undergo sterilization by gamma radiation, steam and/or ethylene oxide. Other materials such as PP (poly-propylene) or HDPE (high density poly-ethylene) or other less expensive materials may be used, too. Especially, the film layer of a single use dispense interface may be made from such a material, as the contact time with the medicament is rather short (only the time from priming the device until the injection is completed). In an example embodiment, the film layer consists of at least 2 layers. The inner layer shall be out of a biocompatible material like cyclo-olefin polymer (COP) or polypropylene (PP), the outer layer can be formed out of material with a higher stiffness like polyamide (PA). By doing so, the foil itself gets a good stiffness and cannot be destroyed easily.
The exemplary embodiments of the dispense interface of the first aspect of the invention allow a simple manufacturing of the dispense interface. Furthermore, they allow manufacturing the body part from a biocompatible material. Potential problems of material compatibility, absorption and cross contamination between the fluids (e.g. drugs) and the polymer material are overcome by the selection of a biocompatible material and/or by providing at least a part of the fluid channel arrangement by the tubelike fluid elements and/or - for a single use dispense interface - by a short contact time.
Fig. 12a illustrates a perspective partially transparent view of an alternative embodiment of a dispense interface;
Fig. 12b-d illustrate alternative embodiments of tubelike fluid elements;
Fig. 13 illustrates the assembly of a rotating flap valve arrangement into the alternative embodiment of the dispense interface illustrated in Fig. 12a;
Fig. 14a-b illustrate a further alternative embodiment of a dispense interface similar to the one illustrated in Fig. 12a after the assembly steps illustrated in Fig. 13.
Fig. 15a illustrates an alternative embodiment of a valve arrangement of a dispense interface; not according to the invention
Fig. 15b illustrates another alternative embodiment of a valve arrangement of a dispense interface; not according to the invention
Fig. 15c illustrates another alternative embodiment of a valve arrangement of a dispense interface; not according to the invention
Fig. 15d illustrates another alternative embodiment of a valve arrangement of a not according to the invention
Fig. 15e illustrates another alternative embodiment of a valve arrangement of a dispense interface; and
The drug delivery device illustrated in Fig. 1 comprises a main body 14 that extends from a proximal end 16 to a distal end 15. At the distal end 15, a removable end cap or cover 18 is provided. This end cap 18 and the distal end 15 of the main body 14 work together to provide a snap fit or form fit connection so that once the cover 18 is slid onto the distal end 15 of the main body 14, this frictional fit between the cap and the main body outer surface 20 prevents the cover from inadvertently falling off the main body. The main body 14 contains a micro-processor control unit, an electro-mechanical drive train, and at least two medicament reservoirs. When the end cap or cover 18 is removed from the device 10 (as illustrated in Fig. 1), a dispense interface 200 is mounted to the distal end 15 of the main body 14, and a dose dispenser (e.g., a needle assembly) is attached to the interface. The drug delivery device 10 can be used to administer a computed dose of a second medicament (secondary drug compound) and a variable dose of a first medicament (primary drug compound) through a single needle assembly, such as a double ended needle assembly.
Similarly, a second or proximal piercing end 408 of the needle assembly 400 protrudes from an opposite side of the circular disc so that it is concentrically surrounded by the sleeve 403. In one needle assembly arrangement, the second or proximal piercing end 408 may be shorter than the sleeve 403 so that this sleeve to some extent protects the pointed end of the back sleeve. The needle cover cap 420 illustrated in Fig. 4 and 5 provides a form fit around the outer surface 403 of the hub 401.
c. a second tubelike fluid element 2200';
Fig. 12a illustrates a perspective partially transparent view of the alternative embodiment of the dispense interface 2000. The dispense interface 2000 comprises a body part 2100. The body part 2100 is injection molded. The first tubelike fluid element 2200a and the second tubelike fluid element 2200a' are molded into the body part 2100 during the injection molding process. The tubelike fluid elements 2200a, 2200a' are identically designed, but mirror symmetrically fixed in the body part 2100. For instance, the tubelike fluid elements 2200a, 2200a' may also be designed differently from each other.
The tubelike fluid elements 2200a, 2200a' and in particular the protruding ends of the tubelike fluid elements 2200a, 2200a', can thus provide the first and second proximal needles 240, 250 as illustrated in Figs. 8 to 11.
The first tubelike fluid element 2200a forms a first inlet 2210a of the dispense interface with its first end/opening, while the second tubelike fluid element 2200a forms a second inlet 2210a' of the dispense interface with its first end/opening. The sections of the tubelike fluid elements 2200a, 2200a' protruding from the body part 2100 are substantially linear and protrude substantially perpendicularly from the body part 2100. The tubelike fluid elements 2200a, 2200a' may establish a releasable fluid connection with the fluid reservoirs 90, 100 respectively.
The tubelike fluid elements 2200a, 2200a' are curved or bent inside the body part 2100, as indicated with the dashed lines. The tubelike fluid elements 2200a, 2200a' may deviate from 0° up to 90° (or above) from a linear course, for example. Here, the tubelike fluid elements 2200a, 2200a' deviate about 45° form a linear course (also confer Fig. 12b).
The body part 2100 further comprises a cylindrical ullage 2110. The ullage 2110 is formed as a recess in the surface of the injection molded body part 2100. The second ends 2220a, 2220a' of each of the tubelike fluid elements 2200a, 2200a' protrude from the body part 2100 into the common ullage 2110, providing a fluid connection between the first and second inlets 2210a, 2210a' and the ullage 2110. The ullage further comprises a third fluid pathway being in connection with the fluid outlet 2400. The ullage further comprises a pivot pin 2120, which can be utilized for a rotating flap valve arrangement (also confer Figs. 13 and 14).
As can be seen from Fig. 12a, a (not yet sealed) fluid channel arrangement is provided within the body part 2100 of the dispense interface 2000 connecting the inlets 2210a, 2210a' with each other and the outlet 2400.
Fig. 12b-c illustrate alternative embodiments of tubelike fluid elements. Fig. 12b exemplarily illustrates the tubelike fluid element 2200a of the tubelike fluid elements 2200a, 2200a' used in the dispense interface 2000 illustrated in Fig. 12a. The tubelike fluid element 2200a is made of a curved or bent needle made of stainless steel. As can be seen, the bent needle 2200a provides a sharp needle tip at its one end forming the first inlet 2210a of the dispense interface 2000. The angle 2230a indicating the deviation of a linear course of the tubelike fluid element 2200a is about 45°. However, smaller or larger curvatures and/or smaller or larger angles may be provided.
Fig. 12c illustrates an alternative tubelike fluid element in the form of a hypo-tube 2200b in a linear state, which may be used instead of the tubelike fluid elements 2200a, 2200a' in form of bent needles. The hypo-tube 2200b may also be manufactured from stainless steel. The hypo-tube 2200b has a middle section 2240b, which section may be laser cut, for example helically, increasing the mechanical flexibility of the hypo-tube in the section 2240b. A polymer sheath is also provided in the section 2240b on the outside of the hypo-tube to ensure fluid tightness. The hypo-tube 2200b can be flexibly bent, for example in an S-like shape, as illustrated in Fig. 12d.
Fig. 13 illustrates the assembly of a rotating flap valve arrangement 2300 into the alternative embodiment of the dispense interface illustrated in Fig. 12a. The rotating flap valve arrangement 2300 has a flap 2310 which is rotatably mounted on the pivot pin 2120 of the ullage 2110.
The flap 2310 is rotatable between a fist and a second position. The working principle of the rotatable flap valve arrangement, however, is described in more details below with respect to Figs. 14b and 15e.
After the rotatable flap 2310 is inserted in the ullage 2110, a film layer 2320 is used in order to seal the ullage of the body part 2100 by bonding the film layer to said body part 2100. A fluid tight connection is thus achieved between the first inlet 2210a and the outlet 2400 and between the second inlet 2210a' and the outlet 2400.
Fig. 14a illustrates a further alternative embodiment of a dispense interface 2000 similar to the dispense interface 2000 illustrated in Fig. 12a after the assembly steps illustrated in Fig. 13. In Fig. 14a the same reference signs as in Fig. 12a are used for parts which are similar.
The only difference of the dispense interface 2000 from Fig. 14a compared to the one from Fig. 12a is that instead of the tubelike fluid elements 2200a, 2200a' illustrated in Fig. 12b in the form of bent needles the tubelike fluid elements 2200b, 2200b' illustrated in Fig. 12d in the form of hypo-tubes are molded into the body part 2100.
Fig. 14b shows an enlarged view of the rotating flap valve arrangement 2300. The flap 2310 of the rotating flap valve arrangement 2300 mounted in the ullage 2110 can rotate about the pivot pin 2120. The ullage 2110 providing a valve chamber has two inlets provided by the ends 2220b, 2220b' of the tubelike fluid elements 2200b and 2220b' and a third fluid pathway being in connection with the outlet 2400 of the dispense interface 2000.
The flap 2310 is rotatable between a fist and a second position. In the first position (illustrated in Fig. 14b), the flap 2310 seals the inlet 2220b' and allows fluid to flow from the inlet 2220b to the outlet 2400. In the second position (not illustrated), the flap 2310 seals the inlet 2220b and allows fluid to flow from the inlet 2220b' to the outlet 2400.
When the fluidic pressure in the inlet 2220b' is for instance increased (e.g. during a dose priming or a dose injecting step), the flap 2310 will be pushed towards the second position as indicated by the arrow in Fig. 14b and vice versa.
Fig. 15a to 15e illustrate embodiments of a valve arrangement not according to the invention for a dispense interface alternative to the valve seal 260 of dispense interface 200 and rotating flap valve 2300 of dispense interface 2000, respectively. In Fig. 15a to 15e the same reference signs are used for parts which are similar.
Fig. 15a illustrates a diaphragm/flap valve arrangement 3000a. The diaphragm/flap valve arrangement 3000a has an inlet 3010 and an outlet 3030. The inlet 3010 may for instance reside in fluid communication with one of the piercing needles 240, 250 of dispense interface 200 or 2000 and the outlet 3030 may for instance reside in fluid communication with holding chamber 280 of dispense interface 200 or the outlet 2400 of dispense interface 2000.
The diaphragm/flap valve arrangement 3000a has a flexible diaphragm/flap 3040. When the fluidic pressure in the inlet 3010 is increased (e.g. during a dose priming or a dose injecting step), the diaphragm/flap 3040 will change from an un-stressed state to a stressed state. In the stressed state, the fluidic pressure bends the diaphragm/flap 3040 as indicated by the arrow in Fig. 15a so that the diaphragm/flap valve arrangement 3000a opens. In this stressed condition, the diaphragm/flap valve arrangement 3000a will allow fluid to flow from the inlet 3010 to the outlet 3030. When the fluidic pressure in the inlet is removed, the diaphragm/flap 3040 will return to its initial position and seal the inlet 3010, preventing backflow.
Fig. 15b illustrates a shuttling valve arrangement 3000b. The shuttling valve arrangement 3000b has a tube 3050. The tube 3050 has two inlets 3010, 3020 and an outlet 3030. The inlet 3020 may also reside in fluid communication with one of the piercing needles 240, 250 of dispense interface 200 or 2000. In the tube 3050 a movable element 3060 (e.g. a piston or a ball) is arranged.
The diameter of the movable element 3060 corresponds to the diameter of the tube 3050 such that the movable element 3060 is movable between a first and a second (longitudinal) position in the tube 3050. In the first position (illustrated in Fig. 15b), the movable element 3060 seals the inlet 3010 and allows fluid to flow from the inlet 3020 to the outlet 3030. In the second position (not illustrated), the movable element 3060 seals the inlet 3020 and allows fluid to flow from the inlet 3010 to the outlet 3030. When the fluidic pressure in the inlet 3010 is for instance increased (e.g. during a dose priming or a dose injecting step), the movable element 3060 will be pushed towards the second position as indicated by the arrow in Fig. 15b.
Fig. 15c illustrates a molded duckbill valve arrangement 3000c. The molded duckbill valve arrangement 3000c has a first and a second duckbill valve 3080, 3090. When the fluidic pressure in the inlet 3020 is increased (e.g. during a dose priming or a dose injecting step), the second duckbill valve 3090 will change from an un-stressed state to a stressed state. In the stressed state, the fluidic pressure inverts the naturally flattened shape of the duckbill valve as indicated in Fig. 15c so that the duckbill valve opens. In this stressed condition, the second duckbill valve 3090 will allow fluid to flow from the inlet 3020 to the outlet 3030. When the fluidic pressure in the inlet 3020 is removed, the second duckbill valve 3090 will return to its flattened shape and seal the inlet 3020, preventing backflow. The first duckbill valve 3080 operates in a similar manner as the second duckbill valve 3090 when the fluidic pressure is increased in the inlet 3010.
When the fluidic pressure in the inlet 3010 is increased (e.g. during a dose priming or a dose injecting step), the first flat spring 3100 will change from an un-stressed state to a stressed state. In the stressed state, the fluidic pressure bends the first flat spring 3100 as indicated by the arrow in Fig. 15d so that the flat spring valve arrangement 3000d opens. In this stressed condition, the flat spring valve arrangement 3000d will allow fluid to flow from the inlet 3010 to the outlet 3030. When the fluidic pressure in the inlet 3010 is removed, the first flat spring 3100 will return to its initial position and seal the inlet 3010, preventing backflow. The second flat spring 3110 operates in a similar manner as the first flat spring 3100 when the fluidic pressure is increased in the inlet 3020.
The flap 3120 is rotatable between a fist and a second position. In the first position (illustrated in Fig. 15e), the flap 3120 seals the inlet 3010 and allows fluid to flow from the inlet 3020 to the outlet 3030. In the second position (not illustrated), the flap 3120 seals the inlet 3020 and allows fluid to flow from the inlet 3010 to the outlet 3030.
Then, in step 602, if the dispense interface is provided with a first safety element, like a needle cover, the first safety element can be removed from the first proximal needle and/or the second proximal needle, each of which may be provided by a tubelike fluid element. For instance, if a predetermined braking line is provided, the fist safety element can be detached by an angular movement performed by the user. It shall be understood that in alternative embodiments, the safety element can be formed by caps or the like.
Insulin derivates are for example B29-N-myristoyl-des(B30) human insulin; B29-N-palmitoyl-des(B30) human insulin; B29-N-myristoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl- ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-Y-glutamyl)-des(B30) human insulin; B29-N-(N-lithocholyl-Y-glutamyl)-des(B30) human insulin; B29-N-(ω-carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(ω-carboxyhepta¬decanoyl) human insulin.
Dispense interface for an ejection device (10), said dispense interface comprising:
- at least two inlets (2210a, 2210a', 2210b, 2210-b');
- at least one outlet (2400);
- an integral body part (2100); and
- a fluid channel arrangement within said integral body part (2100) configured to provide fluid communication between said at least two inlets (2210a, 2210a', 2210b, 2210b') and said at least one outlet (2400);
- an ullage (2110) formed as a recess in a side of the integral body part;
- a rotatable flap (2310) positioned within the ullage and configured to rotate between:
a first position wherein the flap (2310) seals a first of the said inlets (2210a, 2210a', 2210b, 2210b') and
allows fluid to flow from a second of the said inlets (2210a, 2210a', 2210b, 2210b') to the outlet (2400); and
a second position wherein the flap (2310) seals the second said inlet (2210a, 2210a', 2210b, 2210b') and
allows fluid to flow from the first said inlet (2210a, 2210a', 2210b, 2210b') to the outlet (2400);
- wherein each of said at least two inlets (2210a, 2210a', 2210b, 2210b') is formed from a tubelike fluid element (2200a, 2200a', 2200b, 2200b');
- wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') is molded into the integral body part (2100); and
- wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') provides at least a part of the fluid channel arrangement within said integral body part (2100) and wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') is at least partially curved.
Dispense interface according to claim 1 , wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') is configured to establish a releasable fluid connection with a corresponding fluid connector of a fluid reservoir (90, 100) of said ejection device (10) when said dispense interface (2000) is attached to said ejection device (10).
Dispense interface according to claim 1 or 2, wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') is a needle or a hypo-tube.
Dispense interface according to any of the claims 1 to 3, wherein said at least one outlet (2400) is formed from a fluid connector, wherein said fluid channel arrangement empties into said fluid connector, and wherein said fluid connector is configured to establish a fluid connection with a corresponding fluid connector of a needle assembly (400), when said needle assembly (400) is attached to said dispense interface (2000).
Dispense interface according to any of the claims 1 to 4, wherein said at least one outlet (2400) is formed from a needle, wherein said fluid channel arrangement empties into said needle.
Dispense interface according to any of the claims 1 to 5 said dispense interface further comprising:
- a film layer (2320);
- wherein said film layer (2320) is bonded to said integral body part (2100) to seal said fluid channel arrangement, in particular said ullage (2110), of said integral body part (2100).
A method for manufacturing a dispense interface according to any of the claims 1 to 6 said method comprising:
- providing at least two tubelike fluid elements (2200a, 2200a', 2200b, 2200b'); wherein each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') is at least partially curved
molding each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') into an integral body part (2100) such that each of said tubelike fluid elements (2200a, 2200a', 2200b, 2200b') provides at least a part of a fluid channel arrangement within said integral body part (2100).
A method according to claim 7 said method further comprising:
- providing a film layer (2320); and
- bonding said film layer (2320) to said integral body part (2100) after molding the integral body part (2100) to seal said fluid channel arrangement of said body part (2100).
- a dispense interface (2000) according to any of the claims 1 to 6
- an ejection device (10);
- wherein said dispense interface (2000) is attached to said ejection device (10).
System according to claim 9, said system further comprising:
- a needle assembly (400);
- wherein said needle assembly (400) is attached to said dispense interface (2000).
System according to claim 9 or 10 wherein said ejection device (10) is a medical device configured to eject a medicament (92, 102).
EP13735039.3A 2012-07-11 2013-07-10 Dispense interface for an ejection device Active EP2872198B1 (en)
EP13735039.3A EP2872198B1 (en) 2012-07-11 2013-07-10 Dispense interface for an ejection device
EP2872198A1 EP2872198A1 (en) 2015-05-20
EP2872198B1 true EP2872198B1 (en) 2017-10-18
EP13735039.3A Active EP2872198B1 (en) 2012-07-11 2013-07-10 Dispense interface for an ejection device
HK (1) HK1206287A1 (en)
2013-07-10 EP EP13735039.3A patent/EP2872198B1/en active Active
2013-07-10 CN CN 201380035768 patent/CN104411346A/en not_active Application Discontinuation
2013-07-10 US US14/412,729 patent/US9610406B2/en active Active
2013-07-10 JP JP2015520981A patent/JP2015525626A/en not_active Abandoned
2013-07-10 DK DK13735039.3T patent/DK2872198T3/en active
2013-07-10 WO PCT/EP2013/064631 patent/WO2014009443A1/en active Application Filing
2015-07-20 HK HK15106874.1A patent/HK1206287A1/en unknown
2017-02-17 US US15/435,433 patent/US20170157337A1/en not_active Abandoned
CN104411346A (en) 2015-03-11
HK1206287A1 (en) 2016-01-08
US20150157797A1 (en) 2015-06-11
US20170157337A1 (en) 2017-06-08
US9610406B2 (en) 2017-04-04
DK2872198T3 (en) 2018-01-22
EP2872198A1 (en) 2015-05-20
WO2014009443A1 (en) 2014-01-16
JP2015525626A (en) 2015-09-07
US9707345B2 (en) 2017-07-18 Method and medical device for adjusting dose of fluid medicament
US10226581B2 (en) 2019-03-12 Hand-held drug injection device and dose setting limiter mechanism therefor
US20160193419A1 (en) 2016-07-07 Drug Delivery Device
US20170043090A1 (en) 2017-02-16 Filling Device for a Drug Delivery Device and System with a Fillings Device and Drug Delivery Device
US10143805B2 (en) 2018-12-04 Drive mechanism for a drug delivery device
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