Source: http://www.google.com/patents/US8070793?dq=5,889,522
Timestamp: 2017-08-22 05:57:24
Document Index: 684481393

Matched Legal Cases: ['arts 9', 'arts 9', 'art 9', 'art 9', 'art 9', 'art 9', 'art 9', 'art 9', 'arts 9', 'arts 9', 'arts 9']

Patent US8070793 - Stent for vessel - Google Patents
Disclosed is a stent for a vessel implanted and left in the vessel of a living body to support the lumen of the vessel from inside. The stent for a vessel consists of a plurality of stent constituting members (4 a and 4 b), formed by combining a plurality of the tubular-body constituting elements (5...http://www.google.com/patents/US8070793?utm_source=gb-gplus-sharePatent US8070793 - Stent for vessel
Publication number US8070793 B2
Application number US 11/718,781
PCT number PCT/JP2005/020737
Also published as CA2587960A1, CA2587960C, EP1813231A1, EP1813231A4, US20070282428, WO2006051912A1
Publication number 11718781, 718781, PCT/2005/20737, PCT/JP/2005/020737, PCT/JP/2005/20737, PCT/JP/5/020737, PCT/JP/5/20737, PCT/JP2005/020737, PCT/JP2005/20737, PCT/JP2005020737, PCT/JP200520737, PCT/JP5/020737, PCT/JP5/20737, PCT/JP5020737, PCT/JP520737, US 8070793 B2, US 8070793B2, US-B2-8070793, US8070793 B2, US8070793B2
Patent Citations (24), Non-Patent Citations (2), Referenced by (6), Classifications (11), Legal Events (2)
US 8070793 B2
4. The stent for a vessel according to claim 1, wherein for each tubular body forming element comprising a stent constituting member, the plurality of tubular body-forming sub elements are each formed with staggered angles by any of approximately 180°, 120° or 90° to a circumferential direction of said tubular body.
12. The stent for a vessel according to claim 1, wherein said neighboring sides of each tubular-body forming sub-element are joined by partially dissolving said yarn using any one of a solvent for dissolving a biodegradable polymer, a solution obtained on dissolving a biodegradable polymer with a solvent or laser light energy.
First, the stent constituting member 4 a is explained. This stent constituting member 4 a is formed by bending the single yarn 3 as shown in FIG. 6. The yarn 3 making up the stent constituting member 4 a is, for example, bent in a zigzag design from the starting point “a” shown at the lower right end of FIG. 6. Initially, the yarn 3 is bent so that the bend 7 protrudes toward the direction of arrow Y1 in FIG. 6. The yarn is then bent so that the bend 7 protrudes toward the direction of arrow Y2 in FIG. 6. The yarn 3 is bent in a zigzag design in succession for plural times so that the directions of protrusion of the bends 7 are reversed in turn. This completes a single tubular-body forming element 5 a.
The tubular-body forming element 5 a, thus obtained, is curved in a semi-cylindrical shape to constitute portion of the tubular segment 6 (see FIGS. 3 and 6).
The yarn 3 is bent in a zigzag design even times to form a single tubular-body forming element 5 a. The tubular-body forming element 5 a is formed by bending the yarn 3 even times, so that when the bend 7 protruding upwards to the direction of arrow Y1 in FIG. 6 is at the sides of the starting point “a” of bending, the bend 7 protruding downward to the direction of arrow Y2 in FIG. 6 is at the ending point of the opposite side, that is, at a terminal end of bending. As a result, the yarn 3 is able to be extended at the terminal end of bending in an upward direction of arrow Y1 in FIG. 6.
The tubular-body forming element 5 a2 of the second stage is formed so as to be placed in the opposite position staggered by approximately 180° from the tubular-body forming element 5 a1 of the first stage.
The tubular-body forming element 5 a3 of the third stage is formed as it is staggered by approximately 180° from the tubular-body forming element 5 a2 of the second stage, so that the tubular-body forming element 5 a3 of the third stage is located at the side of the tubular-body forming element 5 a1 of the first stage, and at the opposite side of the tubular-body forming element 5 a2 of the second stage.
The tubular-body forming element 5 a4 of the fourth stage is formed as it is staggered by approximately 180° from the tubular-body forming element 5 a3 of the third stage, that is, so that the tubular-body forming element 5 a4 of the fourth stage is located at the side of the tubular-body forming element 5 a2 of the second stage, and at the opposite side of the tubular-body forming element 5 a3 of the third stage.
In this manner, the stent constituting member 4 a is formed by combining a plural number of the tubular-body forming elements 5 a in multistage via connecting parts 9 a. Each tubular-body forming elements 5 a are combined continuously via connecting parts 9 a to face each other with the positions at respective stage staggered alternately by approximately 180°.
In the same manner as the stent constituting member 4 a, the other stent constituting member 4 b is also formed by bending the yarn 3 as shown in FIG. 7. The yarn 3 making up the other stent constituting member 4 b is, for example, bent in a zigzag design, from the starting point “b” shown at the left end of FIG. 7. Initially, the yarn 3 is bent so that the bend 7 protrudes upwards to the direction of arrow Y1 in FIG. 7. The yarn is then bent so that the bend 7 protrudes downwards to the direction of arrow Y2 in FIG. 7. The yarn 3 is then bent in a zigzag design in succession for plural times so that the direction of protrusion of the bends 7 are reversed in turn. This completes a single tubular-body forming element 5 b.
The yarn 3, bent to form a tubular-body forming element 5 b, is also bent so that a pair of left and right sides 11 a and 11 b positioned both sides from the bend 7 in between are approximately the same length. A pair of sides 11 a and 11 b formed by bending the yarn 3 in V shape with the bend 7 in between may displace, in the same manner as the foresaid stent constituting member 4 a, with the bend 7 as displacing positions by having an angle θ2 defined between these sides 11 a and 11 b larger or smaller.
The yarn 3 is, in the same manner as the stent constituting member 4 a, bent in a zigzag design even times to form a tubular-body forming element 5 b. The tubular-body forming element 5 b is as well formed by bending the yarn 3 even times, so that when the bend 7 protruding upwards to the direction of arrow Y1 in FIG. 7 is at the side of the starting point “b” of bending, the bend 7 protruding downwards to the direction of arrow Y2 in FIG. 7 is at the ending point of the opposite side, that is, at a terminal end of bending. As a result, the yarn 3 is extended at the terminal end of bending toward the direction of arrow Y1 in FIG. 7.
The yarn 3 extended upwards to the direction of arrow Y1 in FIG. 7 from a tubular-body forming element 5 b1 of the first bottom stage in FIG. 7 is bent in a zigzag design with a connecting part 9 b from the tubular-body forming element 5 b1 of the first stage as a starting point of bending, to form the tubular-body forming element 5 b2 of a second stage. The tubular-body forming element 5 b2 of the second stage is bent not to overlap the bends 7 protruding downwards to the direction of arrow Y2 in FIG. 7 and the bends 7 of the tubular-body forming element 5 b1 of the first stage protruding upwards to the direction of arrow Y1 in FIG. 7, in the same manner as said stent constituting member 4 a.
In the same manner as the tubular-body forming element 5 a provided in the stent constituting member 4 a described above, the tubular-body forming element 5 b3 of the third stage is formed by bending the yarn 3 extending from the tubular-body forming element 5 b2 of the second stage while the tubular-body forming element 5 b4 of the fourth stage is formed by bending the yarn 3 extending from the tubular-body forming element 5 b3 of the third stage in a zigzag design. Since the method of forming those tubular-body forming elements and the structure thereof are same as those of the tubular-body forming element 5 a provided for the stent constituting member 4 a, detailed description therefore is omitted.
As shown FIG. 2, the sides 8 a lying on the side of the starting point “a” of bending of the tubular-body forming element 5 a1 of the first stage, comprising the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the connecting part 9 b to the tubular-body forming element 5 b2 of the second stage, viz. lying on the side of the terminal point of bending of the tubular-body forming element 5 b1 of the first stage of the other stent constituting member 4 b. The side 8 a lying on the connecting part 9 a to the tubular-body forming element 5 a2 of the second stage, viz. lying on the side of the terminal point of bending of the tubular-body forming element 5 a1 of the first stage comprising the stent constituting member 4 a, is abutted in parallel with the side 11 a on the side of the starting point “b” of bending of the tubular-body forming element 5 b1 of the first stage comprising the other stent constituting member 4 b.
Similarly, in the tubular-body forming elements 5 a2, 5 b2, 5 a3 and 5 b3 of the second and third stage, the side 8 a lying on the side of the starting point of bending of the tubular-body forming element 5 a2 of the second stage of the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the connecting part 9 b to the tubular-body forming element 5 b3 of the third stage, viz. lying on the side of the terminal point of bending of the tubular-body forming element 5 b2 of the second stage of the other stent constituting member 4 b, while the side 8 a on the side of the starting point of bending of the tubular-body forming element 5 a3 of the third stage of the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the connecting part 9 b to the tubular-body forming element 5 b1 of the first stage, viz. lying on the side of the terminal point of bending of the tubular-body forming element 5 b3 of the first stage of the other stent constituting member 4 b. The side 8 a lying on the connecting part 9 a to the tubular-body forming element 5 a3 of the third stage, viz. lying on the side of terminal point of bending of the tubular-body forming element 5 a2 of the second stage comprising the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the side of the starting point of bending of the tubular-body forming element 5 b2 of the second stage comprising the other stent constituting member 4 b, while the side 8 a lying on the connecting part to the tubular-body forming element 5 a4 of the forth stage, viz, lying on the side of terminal point of bending of the tubular-body forming element 5 a3 of the third stage comprising the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the side of the starting point of bending of the tubular-body forming element 5 b3 of the third stage comprising the other stent constituting member 4 b.
As for the tubular-body forming elements 5 a4 and 5 b4 of the fourth stage, the side 8 a on the side of the starting point of bending of the tubular-body forming element 5 a4 of the fourth stage comprising the stent constituting member 4 a is abutted in parallel with the side 11 a lying on the side of the terminal point “d” of bending of the tubular-body forming element 5 b4 of the fourth stage of the other stent constituting member 4 b. The side 8 a on the side of the terminal point “c” of bending of the tubular-body forming element 5 a4 of the fourth stage comprising the stent constituting member 4 a is abutted in parallel with the side 11 a on the side of the starting point of bending of the tubular-body forming element 5 b4 of the fourth stage comprising the other stent constituting member 4 b.
Each tubular-body forming elements 5 a and 5 b, formed in the each stent constituting members 4 a and 4 b, respectively, abutted each other as described above are abutted to each other so as to be alternately arranged to up-and-down direction as indicated by arrows Y1 and Y2, as shown in FIGS. 1 and 2. The tubular-body forming elements 5 a and 5 b abutted to each other make up a single tubular segment 6.
The sides 8 a and 11 a may also be joined with a solvent to dissolve a biodegradable polymer composing the yarn 3. That is, part of the sides 8 a and 11 a formed of a biodegradable polymer is dissolved and joined with a solvent. If the yarn 3 is formed of polylactic acid (PLLA), 1•4-dioxane is used as the solvent.
Further, the sides 8 a and 11 a may also be joined by using a solution of the biodegradable polymer obtained on dissolution with a solvent. The biodegradable polymer used here is the same kind of material as of the yarn 3. In case the yarn 3 is formed of polylactic acid (PLLA), the solution obtained on dissolving polylactic acid with a solvent 1•4-dioxane is used.
Since the tubular body 2 of the present embodiment is comprised with a paired stent constituting members 4 a and 4 b exhibiting left-and-right symmetry, each tubular segments 6 are combined by the paired connecting parts 9 a and 9 b arranged at opposite positions by approximately 180°. Hence, the multistage-combined tubular segments 6 may be flexed with a paired connecting parts 9 a and 9 b staggered their positions each other by approximately 180°, as displacing portions. Since the tubular segment 6 of above and below are flexed, at this time, with a paired connecting parts 9 a and 9 b staggered their positions each other by approximately 180°, as displacing portions, each of these tubular segment 6 may be flexed to the direction of arrow X in FIG. 1 without generating significant displacement.
In case a tubular body is constituted by combining three stent constituting members which are combined the tubular-body forming elements in multistage form divided a tubular segment into three, each tubular-body forming elements of above and below are combined with their positions staggered by approximately 120° along the circumference of the tubular body to constitute the tubular body.
In case a tubular body is constituted by combining four stent constituting members which are combined the tubular-body forming elements in multistage form divided a tubular segment into four, each tubular-body forming elements of above and below are combined with their positions staggered by approximately 90° along the circumference of the tubular body to constitute the tubular body.
Furthermore, since the stent for a vessel 1 according to the present invention is constituted with plural stent constituting members, different drugs may be contained in the respective stent constituting members 4 a and 4 b. In this case as well, a solvent with a drug dissolved in may then be applied on the surface of the yarn 3 constituting the respective stent constituting members 4 a and 4 b.
The stent for a vessel 1 according to the present invention, thus containing the drug, may also be used as a device for supplying the drug in the living body. In case the stent for a vessel 1 is constituted with plural stent constituting members 4 a and 4 b, plural sorts of drugs may be contained with ease and hence the stent may be used for administering a wide variety of drugs.
EP1543860A1 Sep 25, 2003 Jun 22, 2005 Kabushikikaisha Igaki Iryo Sekkei Thread for vascular stent and vascular stent using the thread
JP2002505146A Title not available
JP2004026174A Title not available
JP2004028615A Title not available
JP2004033579A Title not available
JP2006500121A Title not available
JPH1157018A Title not available
JPH11512306A Title not available
WO2004026174A2 Sep 22, 2003 Apr 1, 2004 Conor Medsystems, Inc. Expandable medical device with openings for delivery of multiple beneficial agents
WO2004028615A1 Sep 25, 2003 Apr 8, 2004 Kabushikikaisha Igaki Iryo Sekkei Thread for vascular stent and vascular stent using the thread
1 International Search Report dated Feb. 21, 2006 (2 pages).
2 Written Opinion of the International Searching Authority for corresponding Application No. PCT/JP2005/020737 filed on Nov. 11, 2005.
Cooperative Classification A61F2/88, A61F2210/0004, A61F2/90, A61F2250/006, A61F2002/828
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:IGAKI, KEIJI;REEL/FRAME:019257/0596