Source: https://patents.google.com/patent/WO2004064902A1/en
Timestamp: 2018-08-19 17:53:42
Document Index: 296673991

Matched Legal Cases: ['art 13', 'art 13', 'art 13', 'art 13', 'art 13', 'art 13']

WO2004064902A1 - Device for administering a pre-determinable dose of a liquid product - Google Patents
Device for administering a pre-determinable dose of a liquid product
WO2004064902A1
WO2004064902A1 PCT/CH2004/000027 CH2004000027W WO2004064902A1 WO 2004064902 A1 WO2004064902 A1 WO 2004064902A1 CH 2004000027 W CH2004000027 W CH 2004000027W WO 2004064902 A1 WO2004064902 A1 WO 2004064902A1
PCT/CH2004/000027
The invention relates to a device for administering a pre-determinable dose of a liquid product, preferably a disposable pen. Said device comprises a container for the product, in which a piston is arranged in such a way that it can be longitudinally displaced in an advancing direction; a sleeve-type mechanism holder; a driven member that can be longitudinally displaced in the mechanism holder and acts on the piston; a drive member that can be displaced in relation to the mechanism holder, in the advancing direction and away from the same, and entrains the driven member during a displacement in the advancing direction; and a dose adjusting mechanism comprising a scale for displaying an actually adjusted dose. The inventive device is characterised in that the mechanism holder comprises a window on the outer periphery thereof. At least one section of the dose scale is located on said window, said section co-operating with a mark coupled to the dose adjusting mechanism, inside the mechanism holder, in order to display the actually adjusted dose.
A device for administering a predetermined dose of a liquid product
The present invention relates to an apparatus for administering a predetermined dose of a liquid product, preferably a disposable injection pen.
are known in known Einwegpens as, for example, from WO 89/07463 for the injection of insulin, the dose to be administered is usually set with a protective cap. The numbers 1 to 20 on the cap are printed. After taking off the cap so it can not be said with absolute certainty what dose was actually set. Re-fitting the protective cap can cause even more uncertainty because the cap can be put back in any desired position.
The further integral multiples of the number 20, ie, the numbers 20, 40, 60 .... are printed on a dose knob so that the dose scale of relatively widely spaced, but common-read sections, which complicates the handling. An effective dose adjustment is actually accomplished by rotating an ampoule sleeve relative to the mechanics are key advantages. When screwing the injection pen, it may therefore happen that the ampoule sleeve is rotated, thereby adjusting the dosage and the effective dosage can not be controlled.
A device according to the preamble of claim 1 is known for example from DE 199 00 827 Cl of the Applicant. The display of the actually set dose is carried out according to the process described in WO 97/36 626, the Applicant principle that a dose arrow cooperates on a mechanism holder with a printed on a rotatable dosing dose scale. The reading accuracy is comparatively low. Problems with the accuracy of reading occur particularly when larger numbers of dosage units that are far in the double-digit unit dosage range to be displayed clearly.
It is an object of the present invention to further develop an apparatus of the described type such that larger dosages may be indicated and in a simple and reliable manner with simple handling adjusted.
This object is achieved by a device having the features of claim 1. Further advantageous embodiments are subject matter of the related subclaims.
According to the invention the preferably sleeve-shaped mechanism holder on its outer circumference, a viewing window, wherein at least a portion of the dose scale is, which portion cooperates with an input coupled to the dose setting mark in the interior of the mechanism holder to display the actually set dose of the device. The formed as a recess or be integrated on the outer periphery of the mechanism holder viewing window can be closed off by a transparent material to protect the device mechanism.
According to the invention need not be provided no additional space for mounting an actually set dose indicating mark. Rather, one coupled to the dose setting member on which the tag is attached, are used in the interior of the substantially sleeve-shaped mechanism holder. Thus, an advantageous space-saving construction of the device according to the invention can be implemented without additional elements must be provided.
The label may be a color contrasting to the other elements of color field, a color marking, for example, stroke 'or spiral marking action. Preferably, the marking is provided on the serving for driving the output element drive element or an input coupled to this element, for example on a located near the front end of the drive member cams or collar which projects radially from the outer surface of the drive member, or on a spiral orbiting serving of a front edge of the metering sleeve-shaped dosing. Preferably, the element is provided with the mark is used, at the same time as a stop which is axially adjustable, for example by axial displacement or by turning a threaded rod or the like to limit a maximum stroke of the piston for injection. It is advantageous that the adjusting movement of the element or the stop element can be automatically used for axial adjustment of the color marker so that no further elements are required more for a dose display.
Preferably, the dose scale is formed in two parts and comprises a first portion that is used to display more dosage units, for example integer multiple of 10 it dosage units, and a second portion which is used to display smaller dose units, for example a fraction of the larger dosage units, for example, 1-er dosage units with the numbers 1 to 9. According to the invention, at least a portion of the dose scale, more preferably the large dose units indicating portion disposed at the viewing window, preferably in the axial direction, that is, in the feed direction of the ink marking, and along a longitudinal side of the viewing window.
In the case of the smaller dosage units indicating portion is preferably numerals, which are distributed at equal angular intervals on the outer circumference of a sleeve-shaped, rotatable dosing member. For example, the number can be 0 to 9 arranged at the front edge along the outer periphery of a dosing member. In this embodiment, the adjustment length of the mark corresponds to a rotation of the dosing member part of a scale larger dosage units indicating portion, for example the 10-er scale. It is advantageous that larger dosage units can be displayed accurately and clearly with this simple arrangement. Even with relatively small diameter of the dosing member, the numbers can be 0 to 9 arranged clearly visible along the perimeter according to the invention. According to the invention have on the comparatively small outer circumference no higher numbers, especially not integer multiples of the larger dosage units are attached. This allows a clear and easy-to-use display unit actually set dose.
Instead of an outer periphery of the dosing member or the like, the number of the smaller dosage units indicating portion of the dose scale can also be arranged on the outer periphery of the mechanism holder located inside the rotatable element is in the range of the viewing window. It is advantageous that the larger and smaller dosage units can be simultaneously displayed and clear in the region of the viewing window.
As the driven member preferably stangenformige bodies are used, the axially acting on the piston to advance these product ejection. For a space-saving construction of a drive device is constructed in two parts and comprises an in and counter to the advancing direction of the piston movable drive member and a movable only in the feed direction and locked against the direction of feed driven member. To this end, the output member is held relative to the mechanism holder secured against counter to the advancing direction of the piston, for which purpose locking means are provided on the rod body, which cooperate with correspondingly shaped to locking means which are connected to the mechanism holder. Further, the drive member comprises further correspondingly designed latching means which cooperate with locking means on the rod body. As latching means preferably mechanical latch means are used preferably to transfer rows of teeth with sawtooth-shaped teeth flanks or an external thread on the rod body, which allows the adjustment of the dose immediately by turning a dosing member to the drive member. The drive member itself is preferably formed sleeve-shaped and surrounds the rod body along its entire length substantially. Preferably, stop means are provided on the outer periphery of the drive member, with associated stop elements acting on the mechanism holder, the casing 'of the device or attached to these shifting secure elements together in order to limit a maximum injection stroke of the piston.
Preferred embodiments of the invention are explained below with reference to the accompanying figures. Show it:
Fig. 1 shows an injection device according to a first embodiment of the present
Invention in a cross section; Fig. 1 a cross-section AA of FIG. 1;
2 is a plan view of the injection device of FIG 1 in a neutral position and in a dosing position. Fig. 3 shows an injection device according to a second embodiment of the present
Invention in a cross section; the injection device according to the Fig. 3 in a plan view in a neutral position and in a dosing position with a nonzero actually set dose and Fig. 4.
In the figures, identical reference numerals designate identical or equivalent elements and / or assemblies.
Fig. 1 shows a longitudinal section of an injection device, in the embodiment, a pen injector according to a first embodiment of the present invention. The injection device 1 comprises a housing having a front housing shell 2 and a fixed with this connected, for example screwed, to the rear casing sleeve 7. The front casing sleeve 2 serves as a housing for serving as a product container vial 4. The vial 4 a liquid product is contained, preferably a solution has a therapeutic or medicinal agent containing or suspension, for example insulin, where the product by axial advancement of the vial longitudinally displaceable piston 5 is distributed from the outlet port 3 of the ampoule. To this end, at the front end of the front housing shell 2, a carrier for an injection needle, cannula or the like. Fastened, in particular screwed. The displacement of the piston 5 in the feed direction, ie, towards the outlet opening 3, caused by a drive means, which is accommodated in the rear housing sleeve. 7 The drive means comprises a driven member, a threaded rod 6, which acts directly on the piston 5, and a drive member 19. When rotation of the dose knob 11 located at the rear end of the injection device 1, the twisted about the sleeve member 13 coupled thereto drive member 19 so that it is held axially on the outer thread of the driven member. 6 The drive member 19 is by axial advancement of serving as an actuator dosage knob 11 geradverschiebbar in the feed direction of the piston 5. The sleeve part 13 is formed along the sleeve-shaped rear end of the drive member 19 within the rear end of the rear casing sleeve 7 and the peripheral wall of the dose knob 11 gap longitudinally displaceable.
The serving as the driven member threaded rod 6 is secured against rotation and longitudinally slidably received in the rear casing sleeve. 7 for example, extending in the axial direction of the threaded rod 6 flat, groove or the like is used. For rotation, which cooperates with a correspondingly shaped in cross-section to guide member (not shown). An axial pulling out, away from the outlet opening 3, the threaded rod 6 is located through the sleeve-shaped at the front end 8 of the front housing sleeve 7 locking means 9, 10 is prevented. In this example, the locking means 9, 10 catch hooks which engage in the thread of the threaded rod 6 is. The external thread of the threaded rod 6 has a sequence of from pointing in the direction of saw-tooth edges and substantially radially inwardly directed edges. As shown in FIG. 1, close the latches 9, 10 with the rotation and the longitudinal axis L of the thread of the threaded rod 6 forms an acute angle corresponding to the angle of the flank of the external thread of the threaded rod 6. The locking hooks 9, 10 in the axial direction at different heights corresponding to the pitch of the external thread. Due to the cooperation of the front end of the locking hook 9, 10 with the rear edge of a respective tooth flank of the driven member 6 is moved secured against axial withdrawal. However, the locking means 9, 10 do not work against an axial advancement of the threaded rod. 6 Rather, the locking means 9, 10 are designed elastically bent outward radially during advancement of the threaded rod 6, in order to slip on the tooth flanks. The angular position of the threaded rod 6, and the positions of the front ends of the locking means 9, 10 are coordinated so that the locking means 9, 10 in the illustrated in the upper part of FIG. 2 zero position in which a vanishing dose is set, or at integer 10-he fully engaged doses (10, 20, 30 ....) on the back of the associated tooth flank.
During rotation of dose knob 11 against the direction of rotation of the external thread of the driven member 6, the sleeve-shaped drive member 19 rotates due to the coupling by the sleeve part 13. Threaded nut formed due to the threaded engagement of the of the two carriers 21, 22 at the front end of the drive member 19 thus moves the drive member 19 during rotation of dose knob 11 at the thread of the driven member 6 up and is so axially displaced away. Here, a in which, in the Fig. 1 illustrated embodiment, formed as a circumferential projection cam 20 migrates gradually into the space formed with the sleeve-shaped stop member 16 space 18 inside so long until the axially rear end of the cam has reached 20 at the front end of the stop sleeve 16, in which case a maximum administrable dose would be adjusted.
If the user has set the desired dose which is indicated by the discussed below dose scale, so the injection of the liquid contained in the ampoule 4 by axially advancing the serving as the actuator dosage knob 11 is effected, the result of the coupling by the sleeve member 13, the rotatable drive member 19 axially advances.
In the embodiment shown in Fig. 1 zero position, the front end of the cam 20 abuts the formed by the radial step of the front end 8 of the rear casing sleeve 7 stop, so that neither the drive member 19 nor be pushed forward with this coupled output member 6 further axially can. Starting from this zero position is created during rotation of dose knob 11 and the thereby caused axial resetting of the drive member 19 is a clear Dosierweite between the front end of the cam 20 and the back of the front end 8 of the rear casing sleeve 7. These not shown possible Dosierweite corresponds one to one to the number rotations of the dosing member 11, which is converted via the threaded engagement of the drive member 19 to the driven member 6 in an axial adjustment movement of the cam 20th
In the outer peripheral surface of the rear casing sleeve 7 which is disposed in the Fig. 2 shown in plan view rechteckfδrmige viewing window 17 in which, for example, a mold made of a transparent plastic plate may be used that provides a view into the underlying interior of the rear casing sleeve 7. the viewing window 17 may also be formed in the method of primary shaping, for example in the two-component injection-molded of an opaque plastic component and a transparent for the viewing window. In the embodiment shown in Fig. 1 zero position of the injection device, ie, at zero actually set dose, the rear end of the cam 20 is aligned with the front end of the viewing window (not shown) or with 17 a provided at the viewing window 17 zero mark. Alternatively, one arranged on the outer peripheral surface of the drive member 19 in the region of the viewing window 17 mark (not shown) aligned with the front end of the viewing window 17 or the aforementioned zero mark. In this way, the user is shown the zero state of the dosing.
As can be seen from Fig. 1, the cam 20 or the aforesaid provided on the outer peripheral surface of the drive member 19 travels marking during the axial return of the drive member 19 continues into the viewing window 17. This is inventively exploited to show the actually set dose. For this purpose, the outer peripheral surface of the cam 20 and the outer peripheral surface of the drive member 19 in the region of the viewing window 17 form a clearly perceptible color contrast behind the cam 20th For example, the outer peripheral surface of the drive member 19 is color-conformed as the outer peripheral surface of the rear casing sleeve 7 and forms the outer peripheral surface of the cam 20 a color contrast. During the axial resetting of the driving member 19 thus travels a color pattern according to the invention with perceptible contrast, for example black / white, in the viewing window 17 into, as shown in FIG. 2 can be removed.
As shown in Fig. 2, is divided at the outer edge of the viewing window 17 in a longitudinal direction in integer multiples of the number 10 10-er scale 25 is formed. This 10 it forms a portion of the scale 10, he-25 and the scale 24 1 he dose scale formed entirely of the scale. As shown in FIG. 2, the 1-er scale 24 a total of 10 formed at equal angular intervals on the outer circumference at the front end 12 of dose knob 11 markers on, for example, the numbers 0 to 9. When one rotation of the dose knob 11 thus reverses the 1's back to her old scale angular position. At a rotation of dose knob 11, however, the color coding shown in black in Fig. 2 moves on the outer periphery of the cam 20 to the numerical value 10 continue on the 10-er scale 25 thus acts the 10-er scale 25 with the coupled to the dose knob 11 marking on the outer peripheral surface of the cam 20 together to show the actually set dose. More specifically, the actually set dose from the on the 10-er scale 25 read integer multiple of the number 10 and the read on the scale 24 1's numerical value uniquely sets together. Even with a small diameter of the rear casing sleeve 7 can be sufficiently easy to read numbers ranging from 0 to 9, on the outer circumferential surface of the front end 12 of dose knob 11 attach. Thus, the present invention larger doses can be adjusted easily read.
Alternatively, the numbers may be the 1-er scale 24 is also arranged directly on the outer peripheral surface of the drive member 19 in the region of the viewing window 17 and / or on the outer peripheral surface of the cam 20 with sufficient contrast to the background. In such an alternative embodiment, the numerical values ​​would be located from 0 to 9 spiraling on said outer peripheral surface at equal angular intervals. For dosing and administering a dose of the first embodiment is carried out as follows:
First, the injection device is brought into the position shown in FIG. 1 and in the upper part of FIG. 2 null position where further axial advancement of the driven member 6 toward the discharge port 3 due to the abutment of the front end of the cam 20 at the rear end the circumferential projection is inhibited 8 reliable. Starting from this zero position no product can be distributed from the ampoule 4 without re-dosing. As shown in FIG. 2, the color marking on the outer peripheral surface of the cam 20 in the zero position is out migrated from the viewing window 17, and shows the marking arrow 26 to the numerical value "0" of the 1-er scale 24 at the front end of the operating knob 11.
For adjusting the dose of the dose knob 11 is rotated, so that, due to the threaded engagement at the front end of the drive member 19 6 of the cam 20 is held axially in the external thread of the driven member. The color marker moves on the outer peripheral surface of the cam 20 gradually in the viewing window 17. At the same time the dose knob 11 is moved back by the axially measured, light Dosierweite X and gives a view of a stop 15 of the rear casing sleeve 7. The user can actually set any time the 1-dose he read by reading scale 24 and the 10-er scale 25th If the user has accidentally set too large a dose, he can reduce it again by turning the dose knob 11 unless a not shown locking means prevents backward rotation of the dose 11 in yet another embodiment.
After setting the correct dose of the user pierces the injection needle, not shown, into the body tissue. By axially advancing the operating member serving as dose knob 11 toward the outlet port 3, the injection is carried out until finally the zero position is reached again. For re-use is important to note that the numerical value of 1, it may be fundamentally different from zero scale 24th Therefore, the user must first of all the 1's turning scale 24 on the numerical value of zero before a new dose and not eingestochener injection needle. Thus, none of the dose selection movement takes place by the process of zeroing comparable relative movement between the drive member 19 and the driven member 6, the dose knob 11 and the sleeve member 13 are interconnected so that on the one hand, the dose can be selected by means of the dose knob 11, but on the other hand, a relative rotation can take place between the dose knob 11 and the sleeve part 13 for the purpose of zeroing. For this purpose, between the dose knob 11 and the sleeve part 13 is a sliding clutch is formed so that the dose knob 11 and the sleeve part run 13, the Dosierdrehbewegung for dose selection in common, but a relative rotation between the dose knob 11 and the sleeve member 13 is possible for the zeroing when the drive member is in its axially forwardmost position, in which it is against the housing sleeve 7 to the stop. The slip clutch is soft enough so that it can not cause a buckling of the locking means 9 and 10 and to a tilting of the carrier in the zeroing join 21 and 22nd The slip clutch may alternatively, though less preferably, be formed between the sleeve part 13 and the drive member 19th In a simplified execution of the dose knob 11 and the sleeve member 13 are not disconnected from each other, that is, no slip clutch is provided. However, in a zeroing the injection device must then be converted by axially advancing the dose knob 11 in the illustrated zero position to be able to set a new dose reliable.
In a further alternative embodiment of the sleeve-shaped dose knob 11 may be relative to the sleeve part 13 or the sleeve-like stop member 16 are pulled out, while maintaining its angular position from the injection device. 1 In this fast 11 pressing locking means radially against the inner circumference of dose knob on the outer peripheral surface of the sleeve. 13 During the axial pushing back the dose knob 11, coupled to the drive member 19 sleeve portion 13 and sleeve-shaped stop element 16 is then advanced axially. When the cam 20 returns to the stop to achieve the zero position, the aforementioned locking means are released, so that the dose knob 11 can fully return to its original position.
FIGS. 3 and 4 show a second embodiment of the present invention in a longitudinal section and in a plan view. The injection device according to the second embodiment is basically 199 00 827 Cl of the present applicant, the contents of which are hereby expressly incorporated by way of reference in the present application from the patent document DE. In the second embodiment serves as the driven member a rack 27. The rack 27 is formed by a cross-sectionally rectangular rod body which is provided in a front with respect to the direction of advance range on all four sides with a saw-tooth. In Fig. 3, two on opposite sides of rack 27, referred to the locking means 9, 10 oppositely formed with rows of teeth 34 and 35. In addition to the two rows of teeth 34 and 35, the rack 27 has two other, formed on opposite side surfaces of the rack 27 Sägezahnreihen, one of which is designated by the reference numeral 36 in Fig.3. The teeth of the row 34 to 36 are sawtooth-shaped and have a plane sloping in the direction of tooth flank and a substantially radially inwardly extending back on. The locking means 21 and 22 are designed as latching lugs, as shown in FIG. 3, formed in the axial direction at different heights. In full engagement, the locking means 21, 22 engage completely in from the back of a first tooth and a tooth flank of a counter to the advancing direction of the next tooth of the respective teeth row a.
The four rows of teeth have the same tooth pitch. They are each disposed within a tooth pitch at an offset with respect to the direction of feed, as is disclosed in detail in the referenced DE 199 00 827 Cl of the Applicant. Accordingly, the locking means 21, 22 or 9, 10 and two further blocking agents are (not shown) which cooperate with the respective facing another rows of teeth, with respect to the feed direction at the same height in each 90 ° angular distance. Because of the tooth row offset always only one of the locking means engages with a deepest meshing into a tooth space of 'facing it teeth, when the rack is moved 27th The other three locking means are located opposite each flanks of teeth of each of them facing rows of teeth, so that these other locking means are bent away resiliently from the rack 27th With a displacement of the rack 27 in the direction of the locking means 9, 10 come in this way successively in engagement with the lowest them respectively facing row of teeth; it results overall in an alternating engagement of the locking means, as in the aforementioned DE 199 00 827 Cl is described in detail. The elastically respectively in a tooth root or a tooth base towards fully snapped-in locking means 9, 10 locks the rack 27 against displacement counter to the advancing direction.
According to the second embodiment, the drive means comprises a driven member, the rack 27 which acts directly on the piston 5, and the drive member 19 which is provided with locking means 21, 22, similar to the above locking means 9, 10,. The drive member 19 is supported geradverschiebbar in and counter to the advancing direction of the piston 5 in the rear casing sleeve. 7 A lid 38, which is secured against shifting with the drive member 19 which projects from the housing of the injection device 1 also backwards.
Designed as a dosing sleeve body 30 is secured against the rear casing sleeve 7, for example due to the illustrated snap-in connection, but rotatably connected to the common longitudinal axis. By turning the dosing member 30, the maximum travelable Dosisweglänge in the feed direction of the drive member 19 and the rack 27 is adjusted and thus also the maximum distributable at an injection dose of product. For this purpose, a front sleeve member of the dosing member 30 spirally formed circumferentially on its front end face 31, that is, the front sleeve member 31 falls with respect to the longitudinal axis of the injection device 1 of a foremost end surface portion in a circumferential direction, proceeding from. The dosing member 30 can generally be formed in accordance with a treppenfδrmig also described in WO 97/36 625 and cooperating dosing described in the dosing with the drive member 19 as there. The dosage is in the in the Fig. 3 and in the upper part of FIG. 4 zero position shown, that is, in the front with respect to the feed direction position of the drive member 19 in which a radially projecting from the outer circumferential surface of the drive member 19 abuts collar or cam 29 at a space formed by the rear casing sleeve 7 stop. In this zero position, the dose scale hereinafter described with reference to Fig. 4 indicates the numerical value of zero. In this forward position of the drive member 19 the dosing member 30 is rotated relative to the rear casing sleeve 7, until it has reached the desired dosing position. In this metering position 33 opposite end face of the dosing member 30 remains a light-metering clearance between a likewise protruding from the outer circumferential surface of the drive member 19 further collar or cams 33 and these cams. To this metering clearance, the drive member 19 can be withdrawn against the direction of feed to product distribution relative to the rear casing sleeve 7 and thus also relative to the piston. 5 Retraction is done manually by axially pulling out the lid 25 from the injection device 1. The metering clearance is equal to the product Dosisweglänge in the subsequent administration.
In a pushing back or retracting the drive member 19, the rack 27 remains in its previously occupied in the dispensing displacement position relative to the housing, that is, upon proper operation in the embodiment shown in FIG. 3, the zero position. The rack 27 is secured by formed on the rear casing sleeve 7 locking means 9, 10 against displacement counter to the advancing direction. The locking means 9, 10 are locking cams, which are each formed at a front end of a resilient tongue and zuragen of her tongue radially inwardly on the rack 27th The locking means 9, 10 operate depending facing them with one, above-described rows of teeth of the rack 27 together such that they permit displacement of the rack 27 in the feed direction and prevent a displacement against the feed direction by positive locking engagement.
In FIG. 3, the injection device is shown in an initial position or zero position, in which the rack 27 also occupies its rearmost position relative to the rear casing sleeve 7 and relative to the drive member 19. In this starting position the rear casing sleeve 7 is fully assembled with the rack 27 and drive member 19 including the cover 38 and dosing member 30 supplied by the manufacturer. The starting position thus corresponds to the storage position of the injection device, in particular the drive and metering means of the injection device. In the exemplary embodiment, the injection device is a Einwegpen. Reusability, ie, an exchange of the ampoule 4, but can be achieved with simple modifications.
In the zero position of the injection device with an inserted vial 4 to be administered with the first injection product dose is set by the user. To this end, the dosing member is rotated to a certain rotational position 30, corresponding to the desired product dosage. In this rotational position, the cam 33 has the drive member 19 to the opposite him front end face of the dosing member 30 has a clear metering clearance. Only the locking means 9 is located in the zero position at a tooth back of the row of teeth 34 on locking stop. This also applies to the catch 21. The other blocking means and drivers are not completely in a locking engagement with the associated row of teeth.
The drive member 19 is retracted by pulling on the lid 38 from the injection device 1 out of its most forward position relative to the rear casing sleeve 7 counter to the advancing direction. In the retraction of the drive member 19 the driver 21 to slide 22 via the facing them rows of teeth 34, 35 of the rack 27. The rack 27 itself remains stationary, since it is prevented from driving against the feed direction by the blocking means. 9 The cover 38 and with this move secured coupled drive member 19 is so long drawn out of the injection device 1, until the cam 33 abuts the opposing front end surface of the dosing member 30 into abutment. This tactile resistance is the signal that the injection device 1 is loaded and is ready for injection for the user.
When injected, the drive member 19 and hence the rack 27 are shifted in the direction of pressing against the cover 38 to the preselected Dosisweglänge. The rack 27 pushes the piston 5 in the ampoule 4 at the outlet 3 and it will be distributed product. The distribution takes place until the projecting from the outer surface of the drive member 19 and the collar cam 29 abuts the radially inwardly directed projection of the rear casing sleeve 7 to the stopper. In this forward position of the locking means 9, 10 again engages fully in a tooth gap of the associated rows of teeth 34 to 36 of the rack 27 a.
In an alternative embodiment, the locking means and the carrier can also be all arranged at the same height with respect to the feed direction, 199 00 827 Cl of the Applicant is described in detail as in the DE.
FIG. 4 shows the injection device according to the second embodiment in a schematic plan view, in two different dosage positions, namely at choice of 5 dose units (upper part of Fig. 4) and selection of 37 dosage units (lower part of Fig. 4). In the outer circumferential surface serving as the mechanism holder rear casing sleeve 7, a window 17 is provided, which provides a view into the interior of the rear casing sleeve. 7 In the viewing window 17 preferably is a window of a transparent material, in particular plastic. Clearly visible is the spirally circumferential front face 32 of the front sleeve member 31 forming in the viewing window 17 in any rotational position of the dosing member 30 has a transverse to the viewing window 17 inclined line. At the spirally rotating the front end face 32 of a suitable color marking can be provided, for example, a color line with sufficient color contrast. In the example shown in the Fig. 4 embodiment, the front sleeve member 31 is colored in clearly perceptible contrast to the rest of the dosing member 30, so that the dyed area can be clearly perceived by the user 40. These aforementioned color markings, which are coupled to the dose setting mechanism acting as a dosing member 30, cooperate with the dose scale as follows:
Along the long side of the substantially rectangular display window 17, the illustrated 10-he scale 25 is provided that indicates how many Zehπer dose units are selected. The 10 scale it forms a first part of the dose scale, the addition, the 1-it comprises scale 24 at the front end of the dosing 30th the numbers of 1's 24 (numbers 0 to 9) distributed scale at equal angular intervals along the outer periphery of dosing member 30 are preferred. The 1's scale 24 is in turn formed of a plurality of 1's scales, which follow along the outer circumference of the dosing member 30 to each other. The plurality of 1's scales of the scale 24 are each formed identical, each of said scales indicating the individual dosage units from 0 to 9. The number of said plurality of 1's scales of the scale 24 corresponds to the maximum number of selectable 10-er dosage units. In the second embodiment, in the total 40 dosage units, ie, four tens dosage units constituting the maximum dose, therefore there is a 1-er scale 24 a total of four circumferentially adjacent 1's scales. Thus, the 1-to periodically shows scale 24 at each quarter turn of the dosing member 30 of the same numerical value in the range of 0 to. 9 The unit of the set dose per decade corresponding number of 1's scale 24 is indicated by the marking arrow 26 at the rear end of the rear casing sleeve. 7 From the 1-er scale 24 and the 10-er scale 25 can be seen clearly and safely actually set dose. Because of the formation of the 1-er scale 24 from a plurality of individual scales could Although the dose decades, for example, axially he 1-scale 24 to be formed circumferentially to the dosing member 30 next to the. However, the display means of the viewing window 17 and the legible through the viewing window 17 marking in the form of the end face 32 or a different type of marking of the dosing member 30 improves the reading, at least in terms of the clarity. As a result, the risk of incorrect dosage is reduced due to a misinterpretation of the indicated dose level. The numbers of 1's scale 24 can (. In the lower portion of Figure (under contrasts for this purpose), or in the contrasting color to the area of ​​the front sleeve member 31 4 shown in white alternatively on the outer peripheral surface of the front sleeve member 31 in the area of ​​the color marker 40 ) may be disposed, namely also preferably distributed at regular angular intervals over an angular range of 360 °. In such an alternative embodiment, the digits of 1- it spirally on the front sleeve member 31 to scale 24 run.
In the embodiment shown in Fig. 3 starting position of the numerical value of 10 to 10. can automatically scale 25 within the range of 0, depending on the previously selected dose on the 1-he a non-zero value are displayed scale 24. For the setting of a new dose of the 1-he turned back before an injection scale 24 by rotating the dosing member 30 to zero. After loading of the injection apparatus by pulling out the lid 38 and advancing the cover 38 and coupled thereto rack 27 so as resulting residual dose is expelled. Subsequently, the injection device 1 is in the zero position in which the next dose to be administered is set as follows.
To set the dose, the dosing member 30 is twisted. The digits of 1- he scale 24 on the marking arrow 26 over and travels spirally circumferential front face 32 of the front sleeve member 31 gradually in the viewing window 17 in. Running Finally, on the dose scale 24, 25 reaches the desired dose.
Subsequently, the injection apparatus is pulled out of the cover 38 and drawn out with this move secured coupled drive member 19 from the injection device 1, until the cam 33 comes at this opposite end face of the dosing member 30 into abutment. Thereafter, the user punctures the injection needle into the body tissue and the set dose is administered by advancing the cover 38, which advances when advancing the drive member 19 and the standing in blocking engagement with the rack 27 and the piston 5 by the set Dosisweglänge. After back or further rotation of one scale 24 to the numerical value zero, the aforesaid zero position is reached again, in which a new dose to be administered can be set again.
The color marking on the front sleeve member 31 may alternatively be itself formed spirally circumferential.
An inventive injection device is preferably constructed of injection molded plastic parts and is preferably the treatment of diabetes by injection of pre-selected doses of insulin in the subcutaneous fatty tissue of a patient. In principle, however, can also be administered any other liquid substances, in particular those containing a medicinal or therapeutic agent. In the administration of insulin, a gauge 31 or 30 gauge hypodermic needle is fitted onto the front end of the front housing shell 2 is preferred.
1. A device for administering a predetermined dose of a liquid product from a container (2) for the product by axially advancing a longitudinally displaceable in the container piston (5), the apparatus comprising: a sleeve-shaped mechanism holder (7), one (in the mechanism holder 7 ) longitudinally displaceable driven member (6; 27) on the
Piston (5) is applied, a relative to the mechanism holder (7) in and against the feed direction of the piston (5) adjustable drive member (19) which upon displacement in the feed direction of the output member (6; 27) entrains, and a dose setting mechanism (11 ; 38) with a dose scale (24, 25) for displaying an actually set dose, characterized in that the mechanism holder (7) on its outer circumference a
includes viewing window (17), wherein at least a portion (25) of the
Dose scale is, which coupled to a dose setting mechanism with the
Marker (20; 32; 40) cooperates in the interior of the mechanism holder (7) to display the actually set dose.
2. Device according to claim 1, wherein the viewing window (17) has at least one longitudinal side extending at an angle of less than 90 ° to the feed direction, preferably along the direction of feed, extends.
3. Device according to claim 1 or 2, wherein the portion of the dose scale of a
Tens scale (25) along the longitudinal side of the viewing window (17) is formed.
4. Device according to one in which another portion of the dose scale of one of a scale (24) is formed, whose number and at the same angular intervals over a front peripheral edge of a rotatable dosing of the preceding claims, (12; 30) are distributed.
5. Device according to one of the preceding claims, wherein the
A dose setting mechanism in the interior of the mechanism holder (7) befindliches rotationally movable member (19, 20; 31), which against rotation with a rotatable dosing member (12; 30) of the dose setting mechanism is coupled.
6. The apparatus of claim 5, wherein the rotatable member forms an axially adjustable stop for adjusting the dose of a maximum stroke of the driven member; limits of the device (6 27).
7. Apparatus according to claim 5 or 6, wherein a one-scale on the with the
Dosing member (12; 30) rotationally coupled, rotationally movable element (19, 20; 31) is applied in the interior of the mechanism holder (7).
8. Apparatus according to claim 7, in which the digits of the A scale under uniform
Angular intervals circumferentially and spirally on the outer periphery of the rotatable member (19, 20; 31) are distributed.
9. Device according to one of the preceding claims, wherein the rotatable
A member from the outer periphery of the drive member (19) protruding cam (20).
10. The apparatus of claim 9, wherein the driven member is provided with an external threaded rod bodies (6), wherein the cam (20) elastically deformable drivers (21, 22) are formed, which during a longitudinal displacement of the drive member in the feed direction in a locking engagement associated with the driven member to bring the driven member (6) and release the locking engagement at a longitudinal displacement of the drive member (19) against the feed direction.
11. The apparatus of claim 9 or 10, wherein a front edge of the viewing window (17) is aligned in a null position of the device with a rear edge of the cam (20) is substantially.
12. The apparatus of claim 9, wherein the driven member is a rack (27), wherein at a front end of the drive member (19) having rows of teeth (34-36) of the rack cooperating driver (21, 22) are formed and in which at a front end of the mechanism holder (7) cooperating with the rack Zarinreihen the locking means (9, 10) are formed.
comprises 13. The apparatus of claim 12, wherein the rotatable member (30) at its front end a spiral-shaped circumferential face (32) on its outer circumference, which forms an axially adjustable stop for limiting the maximum stroke of the driven member (27).
14. The apparatus of claim 13, wherein the spirally circumferential end face (32) has on its outer periphery a color mark (40) which cooperates with the dose scale.
15. A device having 12 to 14, the actuation element furthermore connected at its rear end a shifting secured to the drive member (19), sleeve-shaped (38) according to one of the claims.
16. Device according to one of the preceding claims, having at a front end for injection of the liquid product, a gauge 30 injection needle or 31- gauge injection needle.
PCT/CH2004/000027 2003-01-21 2004-01-19 Device for administering a pre-determinable dose of a liquid product WO2004064902A1 (en)
DE10302163.9 2003-01-21
DE2003102163 DE10302163A1 (en) 2003-01-21 2003-01-21 Unit administering medicament, includes inspection window showing section of scale against which internal mark shows dose set
WO2004064902A1 true true WO2004064902A1 (en) 2004-08-05
ID=32602823
PCT/CH2004/000027 WO2004064902A1 (en) 2003-01-21 2004-01-19 Device for administering a pre-determinable dose of a liquid product
DE (1) DE10302163A1 (en)
WO (1) WO2004064902A1 (en)
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WO2015082303A1 (en) * 2013-12-05 2015-06-11 Novo Nordisk A/S A housing for a medical injection device
US10034982B2 (en) 2009-07-10 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
DE102006061992B3 (en) * 2006-12-21 2008-06-12 Ghz Matra Ag metering
DE20013579U1 (en) * 2000-08-08 2001-03-29 Adamaszek Franz Heinz Metering and automatic injection device
DE10302163A1 (en) 2004-07-29 application