Source: http://www.google.com/patents/US7285303?dq=5,884,272
Timestamp: 2016-08-30 09:16:45
Document Index: 438816030

Matched Legal Cases: ['Application No. 00', 'Application No. 00', 'Application No. 01', 'Application No. 01', 'Application No. 97', 'Application No. 96', 'Application No. 96', 'Application No. 2', 'Application No. 2']

Patent US7285303 - Powder material for electrostatic application to a substrate and ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsMethod of electrostatically applying powder material to a substrate, wherein the substrate is a pharmaceutical substrate and the powder material is pharmaceutically acceptable. At least some of the particles of the material comprise a core and a shell surrounding the core, and the material of the core...http://www.google.com/patents/US7285303?utm_source=gb-gplus-sharePatent US7285303 - Powder material for electrostatic application to a substrate and electrostatic application of the powder material to a substrateAdvanced Patent SearchPublication numberUS7285303 B2Publication typeGrantApplication numberUS 10/182,550PCT numberPCT/GB2000/000425Publication dateOct 23, 2007Filing dateFeb 1, 2001Priority dateFeb 1, 2000Fee statusLapsedAlso published asCA2397799A1, EP1255793A1, US20030113445, WO2001057144A1Publication number10182550, 182550, PCT/2000/425, PCT/GB/0/000425, PCT/GB/0/00425, PCT/GB/2000/000425, PCT/GB/2000/00425, PCT/GB0/000425, PCT/GB0/00425, PCT/GB0000425, PCT/GB000425, PCT/GB2000/000425, PCT/GB2000/00425, PCT/GB2000000425, PCT/GB200000425, US 7285303 B2, US 7285303B2, US-B2-7285303, US7285303 B2, US7285303B2InventorsTrevor Ian Martin, Linda Ann ReevesOriginal AssigneePhoqus Pharmaceuticals LimitedExport CitationBiBTeX, EndNote, RefManPatent Citations (100), Non-Patent Citations (23), Referenced by (1), Classifications (18), Legal Events (7) External Links: USPTO, USPTO Assignment, EspacenetPowder material for electrostatic application to a substrate and electrostatic application of the powder material to a substrate
US 7285303 B2Abstract
Method of electrostatically applying powder material to a substrate, wherein the substrate is a pharmaceutical substrate and the powder material is pharmaceutically acceptable. At least some of the particles of the material comprise a core and a shell surrounding the core, and the material of the core and the shell have different physical and/or chemical properties.
This invention relates to a powder material suitable for electrostatic application to a substrate, and to a method of electrostatically applying the powder material to a substrate. In particular, but not exclusively, the invention relates to powder material and its application to the surface of solid dosage forms, for example tablets, especially pharmaceutical solid dosage forms.
A “dosage form” can be formed from any material that can be apportioned into individual units; it may be, but is not necessarily, an oral dosage form. Examples of pharmaceutical solid dosage forms include pharmaceutical tablets, pharmaceutical pessaries, pharmaceutical bougies and pharmaceutical suppositories. The term “pharmaceutical tablet” should be interpreted as covering all pharmaceutical products which are to be taken orally, including pressed tablets, pellets, capsules and spherules. The term “solid dosage form” does not, however, include products such as small pellets and granules where a large number are utilised to provide a single dosage, for example small pellets which are filled into capsule shells for administration, and granules which are compressed to form tablets or sprinkled on the food or drink; such pellets or granules are not themselves each solid dosage forms but rather, when combined together, for example in a capsule or tablet, define in combination a solid dosage form. Examples of non-pharmaceutical solid dosage forms include items of confectionery, washing detergent tablets, repellents, herbicides, pesticides and fertilisers.
A powder material for electrostatic application to a substrate should have certain properties. For example, the electrical properties of the powder material should be such as to make the powder material suitable for electrostatic application, and other properties of the powder material should be such that the material can be secured to the substrate once electrostatic application has taken place.
WO 96/35413 describes a powder material which is especially suitable for electrostatic application to a poorly-conducting (non-metal) substrate such as a pharmaceutical tablet. Because it may be difficult to find a single component capable of providing the material with all the desired properties, the powder material comprises a number of different components which together are capable of providing the material with all or at least as many as possible of the desired properties, the components being co-processed to form “composite particles”. For example, the powder material may comprise composite particles including one component which is fusible to form a continuous film on the surface of the substrate, and another component which has desirable electrical properties.
The present invention provides a method of electrostatically applying a powder material to a substrate, wherein at least some of the particles of the material comprise a core and a shell surrounding the core, the core and the shell having different physical and/or chemical properties. Commonly, the majority of the particles of the material and, generally, substantially all the particles of the material comprise a core and a shell.
Generally, the powder material includes a component which is fusible, and that component may be present in the shell or in the core or in both the shell and the core. Advantageously, the fusible component is treatable to form a continuous film coating. Examples of suitable components are as follows: polyacrylates, for example polymethacrylates; polyesters; polyurethanes; polyamides, for example nylons; polyureas; polysulphones; polyethers; polystyrene; polyvinylpyrrolidone; biodegradable polymers, for example polycaprolactones, polyanhydrides, polylactides, polyglycolides, polyhydroxybutyrates and polyhydroxy-valerates; polysaccharides, for example cellulose ethers and cellulose esters; sugar alcohols, for example lactitol, sorbitol, xylitol, galactitol and maltitol; sugars, for example sucrose, dextrose, fructose, xylose and galactose; hydrophobic waxes and oils, for example vegetable oils and hydrogenated vegetable oils (saturated and unsaturated fatty acids), e.g. hydrogenated castor oil, carnauba wax, and bees wax; hydrophilic waxes; polyalkenes and polyalkene oxides; polyethylene glycol. Clearly there may be other suitable materials, and the above are given merely as examples. One or more fusible materials may be present. Preferred fusible materials generally function as a binder for other components in the powder.
Optionally, or at least one component may be present on the outer surface of the shell. For example, the powder material may also include a flow aid present at the outer surface of the shell. The flow aid reduces the cohesive and/or other forces between the particles of the material to improve the flowability of the powder. The component may be present on the surface of the shell although in addition some may be embedded in the surface of the shell. Suitable flow aids (which are also known as “surface additives”) are, for example, as follows: colloidal silica; metal oxides, e.g. fumed titanium dioxide, zinc oxide or alumina; metal stearates, e.g. zinc, magnesium or calcium stearate; talc; functional and non-functional waxes, and polymer beads, e.g. poly-methyl methacrylate beads, fluoropolymer beads and the like. Such materials may also enhance tribocharging. A mixture of flow aids, for example
The powder material may also include a dispersing agent, for example a lecithin. The dispersing agent is preferably present with the colorant/opacifier (that is, preferably in the core), serving to improve the dispersion of the colorant and opacifier, more especially when titanium dioxide is used. The dispersing component is preferably a surfactant which may be anionic, cationic or non-ionic, but may be another compound which would not usually be referred to as a “surfactant” but has a similar effect. The dispersing component may be a co-solvent. The dispersing component may be one or more of, for example, sodium lauryl sulphate, docusate sodium, Tweens (sorbitan fatty acid esters), polyoxamers and cetostearyl alcohol. Preferably, the powder material includes at lest 0.5%, e.g. at least 1%, for example from 2% to 5%, by weight of dispersing component, based on the weight of the powder material. Most often it is about 10% by weight of the colorant+opacifier content.
Where the coating material is used for “immediate” release tablets, the powder coating material advantageously includes a disintegrant which may disrupt the coating.
Powder having a narrow range of particle size should especially be mentioned. Particle size distribution may be quoted, for example, in terms of the Geometric Standard Deviation (“GSD”) figures d90/d50 or d50/d10 where d90 denotes the particle size at which 90% by volume of the particles are below this figure (and 10% are above), d10 represents the particle size at which 10% by volume of the particles are below this figure (and 90% are above), and d50 represents the mean particle size. Advantageously, the mean (d50) is in the range of from 5 to 40 μm, for example from 10 to 25 μm. Preferably, d90 /d50 is no more than 1.5, especially no more than 1.35, more especially no more than 1.32, for example in the range of from 1.2 to 1.5, especially 1.25 to 1.35, more especially 1.27 to 1.32, the particle sizes being measured, for example, by Coulter Counter. Thus, for example, the powder may have d50=10 μm, d90=13 μm, d10=7 μm, so that d90/d50=1.3 and d50/d10=1.4.
Core Core Resin: Polyvinyl pyrrolidone 40% Colorant: Sunset Yellow 5% Opacifier: Titanium dioxide 10% Charge Control Agent: Cetrimide 1% Microcrystalline Wax 3% Active Material 30% Shell Shell resin: Eudragit E100 10% Surface additives Hydrophilic fumed silica 0.5% Fumed titanium dioxide 0.5% Preparation of the Core
Core Core Resin: Hydroxypropyl methylcellulose 40% acetate succinate Plasticiser: Triethyl citrate 29.6% Charge Control Agent: Benzalkonium chloride 1% Opacifier: Titanium dioxide 10% Colorant: Indigo Carmine 2.5% Colorant: Sunset Yellow 2.5% Wax: Carnauba Wax (m.p. 86� C.) 4% Shell Shell Resin: Eudragit (High Tg) 9% Charge Control Agent: Benzalkonium chloride 1% Surface additive Hydrophilic Fumed Silica 0.4% Preparation of Core
Core Core Resin: Cellulose acetate phthalate 20% Plasticiser: Triethyl citrate 15% Opacifier: Titanium dioxide 10% Charge control Agent/Dispersant: Lecithin 1% Colorant: Red Food Dye 4% Active material 20% Inert Filler: Magnesium aluminium silicate 15% Shell Shell Resin: Polyvinyl pyrrolidone 14.5% Surface additives Alumina 0.25% Silica 0.25% Preparation of Core
The solution of polyvinyl pyrrolidone is added to the suspension of core particles and immediately spray dried at 65� C. to form microcapsules consisting of core particles encapsulated by a thin film of polyvinyl pyrrolidone (˜0.35 micron).
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