Source: https://patents.google.com/patent/CN105102028B/en
Timestamp: 2019-08-24 16:51:51
Document Index: 450013402

Matched Legal Cases: ['art 70', 'art 70', 'art 70', 'arts 72', 'art 110', 'art 110', 'art 110', 'art 44']

CN105102028B - Driving assembly for medicine delivery device - Google Patents
Driving assembly for medicine delivery device Download PDF
CN105102028B
CN105102028B CN201480019964.9A CN201480019964A CN105102028B CN 105102028 B CN105102028 B CN 105102028B CN 201480019964 A CN201480019964 A CN 201480019964A CN 105102028 B CN105102028 B CN 105102028B
CN201480019964.9A
CN105102028A (en
2013-04-10 Priority to EP13163102 priority Critical
2013-04-10 Priority to EP13163102.0 priority
2014-04-08 Priority to PCT/EP2014/056996 priority patent/WO2014166914A1/en
2015-11-25 Publication of CN105102028A publication Critical patent/CN105102028A/en
2019-02-01 Publication of CN105102028B publication Critical patent/CN105102028B/en
The present invention provides a kind of driving assembly for being used for medicine delivery device (100), comprising: shell (10) has proximal end (17) and distal end (16)；And driving mechanism, including piston rod (30) and drive member (40), drive member (40) driving piston rod (30) one drug dose of distribution；With dose (70), it is connected to drive member (40).The component further includes gigback comprising spring member (130).The component further includes movable member (110), is connected to spring member (130).Under setting operation mode, movable member (110) is connected to dose (70), and movable member (110) can be moved to dose setting position from initial position, so that spring member (130) be made to be biased.Under batch operation mode, drive member (40) and movable member (110) separation, make driving mechanism that can apply driving force to driving mechanism by user to operate, the spring member (130) of gigback drives movable member (110) independently of the initial position of driving force towards movable member.
Driving assembly for medicine delivery device
This disclosure relates to the driving assembly of the medicine delivery device of such as syringe-type device and/or pencil type apparatus.
Medicine delivery device is known from such as WO2008/058665A1.
Purpose of this disclosure is to provide the components of the one or more components for the operation for promoting medicine delivery device.
The purpose is obtained by subject matter of the independent claims.Advantageous embodiment and improvement are dependent claims Theme.
An aspect of this disclosure is related to the driving assembly of medicine delivery device.Driving assembly includes having proximally and distally Shell." distal end " of the component of medicine delivery device or medicine delivery device will refer to that the distribution end from medicine delivery device is nearest That end." proximal end " of the component of medicine delivery device or medicine delivery device will refer to that the distribution end from medicine delivery device is nearest That end.
The further aspect of the disclosure be related to include driving assembly medicine delivery device.
Driving assembly further includes driving mechanism.Driving mechanism further includes piston rod.Driving mechanism further include drive member with Drive the drug of piston rod distribution doses.Driving assembly further includes the dose for being connected to drive member.Dose The removable drug to set doses.Connector between dose and drive member is preferably configured so that, when When mobile dose is with setting dosage, drive member also preferably moves in same direction.Driving assembly further includes returning Mechanism, the gigback include spring member.Specifically, gigback is provided so that driving assembly or medicine delivery device it is another Outer component is returned or is resetted during the operation of medicine delivery device.Driving assembly further includes movable member, this is removable Component is connected to spring member.Driving assembly is constructed such that, under the setting operation mode of driving assembly, movable member It is connected to dose.During the setting of dosage, movable member can be moved to dose setting position from initial position.Cause This, spring member is biased.When movable member is in dose setting position, dose can be actuated by the user will drive Component is moved from the setting pattern switching of driving assembly to batch operation mode.Driving assembly is preferably configured so that dose It can be manipulated with manipulating preferred manual by user, such as manually be moved by user.According to this embodiment, it allows users to hold Easily and selectively operating device, so as to set or administered and/or so as to by driving assembly from setting pattern switching to point With operation mode.
In one embodiment, driving assembly is constructed such that, under batch operation mode, drive member and removable structure Part is disconnected, so that driving mechanism can be operated and applying driving force to driving mechanism by user.Driving force is preferably by user Apply through dose.Preferably, driving force is further by user manually (that is, only for example, by the physical force of the hand of user Amount) apply.
In one embodiment, gigback is configured to drive independently of driving force towards the initial position of movable member Dynamic movable member.
As advantage, for example, user is without expending driving gigback institute to during the distribution of dosage in batch operation The power needed.Therefore, the driving force that driving driving mechanism may need can keep very little, and user is conveyed from drug and is filled Set the drug for easily distributing doses.In addition, the driving mechanism of device may be implemented as less sensitive to frictional force, make The length of device or axially extending can reduce.Therefore, in turn, the operability of device can be improved.
Operate possible more particularly to medicine delivery device the dose setting operation and dosage of medicine delivery device distribute behaviour Make.
In one embodiment, spring member is torsion spring.According to this embodiment, it makes antitorque when being coupled or connected to When the component of spring is rotated relative to the component for being also connected to torsion spring, spring member is biased.As further advantage, The biasing of spring member can execute in the fairly small axial cross section of medicine delivery device, so that the axis of medicine delivery device Very little can be kept to length or extension.Therefore, the operability of medicine delivery device can be further increased.
In one embodiment, driving assembly is constructed such that, during the setting of dosage, movable member is in first party It is rotated upwards relative to shell.In this manner it is achieved that during the setting of dosage, as movable member joins It is connected to spring member, spring member is biased.
In one embodiment, driving assembly is constructed such that, during the distribution of dosage, movable member is relative to shell Body rotates in the second direction opposite to the first direction.In this manner it is achieved that during the distribution of dosage, bullet Spring component drives movable member towards its initial position.In addition to the rotation of movable member, movable member is at it from first Beginning position can also axially move during advancing to dose setting position.
Initial position may relate to the following position of medicine delivery device: where not yet setting dosage or dosage by It is set to correspond to the zero dose position of the state of the setting zero-dose of medicine delivery device.Dose setting position may relate to set Determine the position of the drug of doses.
In one embodiment, dose is relative to drive member by spin locking.It is thereby achieved that when with Family starts dose during the setting of dosage, such as when rotating dose, drive member is also for example relative to shell Rotation.Therefore, drive member can also pass through in dose setting position.
In one embodiment, driving assembly includes releasable clutch mechanism.Releasable clutch mechanism is constructed such that , under setting operation mode, dose is rotatable relative to shell.Then, user can manually make dosage structure Part rotates and setting dosage relative to shell.Releasable clutch mechanism is further configured so that, in batch operation mode Under, clutch configuration and supplement clutch configuration interaction, so that dose is rotatably locked relative to shell.From Clutch structure is preferably provided by drive member.Clutch configuration can be protrusion, be integrally formed with drive member.Clutch Structure can further curve inwardly relative to drive member.Complementary clutch structure can be by the other component of driving assembly It provides.Preferably, complementary clutch structure is by shell or the component fixed to shell provides.
In one embodiment, shell is formed by main housing portion and inner housing, and inner housing connects or is rigidly secured to lead Housing parts.
In one embodiment, drive member includes that protrusion (for example, flexible raised) is used to form clutch configuration.Protrusion can To cross the spline of such as inner housing.In order to cross spline, protrusion may need to be bent radially inward or bent.Therefore, institute Mentioned complementary clutch structure can be formed by stating spline.
Under batch operation mode, the protrusion can be prevented from crossing the spline structure of complementary clutch configuration, because For, such as dose or its structure can be arranged so that protrusion is prevented from deflecting relative to drive member, thus it is described prominent Play the spline that cannot cross inner housing.
In one embodiment, movable member is threadedly coupled to shell.Driving assembly is constructed such that, in setting for dosage Between periodically, the axial stroke of dose is by screw thread (specifically by establishing the screw thread of the thread connection of movable member and shell Lead) limit.The thread connection can further limit movable member and/or agent when setting the drug of doses The axial distance that amount component is axially moved relative to shell.
Preferably, the lead of the thread connection between shell and movable member is equal between piston rod and drive member Threaded connection lead (turning also now to hereafter).
In one embodiment, driving assembly is constructed such that, under batch operation mode, by the driving force of user's application Piston rod is transferred to through driving mechanism to drive piston rod along distal direction relative to shell.Therefore, because user is distad The distal side movement of drive member that manually presses dose and may be passed can further be passed to piston rod.It is living Stopper rod can be coupled to piston.The piston can be arranged in the cylindrantherae containing drug.Piston can be axially constrained to Piston rod.When moving piston rod along distal side, piston can also be distally moved relative to cylindrantherae, be allowed to defeated from drug Send the drug of device distribution doses.
Medicine delivery device can be variable dose device.Medicine delivery device can be further disposable apparatus, make It is obtained to be designed to be only used for being intended for single use.For this purpose, it can be transported to user for head in the state of sufficiently assembling Secondary use.Alternatively, device can be reusable device.It is optional that the dosage of the drug of medicine delivery device can be user 's.
In one embodiment, medicine delivery device includes needle or needle assemblies.The drug that can be maintained in cylindrantherae or doctor Treating substance can distribute from medicine delivery device through the needle or needle assemblies.
In one embodiment, movable member and dose couple through releasable rotary locking mechanism.Driving assembly quilt It is configured so that, under setting operation mode, releasable rotary locking mechanism engagement, so that movable member and dose quilt Spin locking.Driving assembly is further configured so that when under setting operation mode, movable member is set in dosage Positioning is set, and user is distally moved dose, and releasable rotary locking mechanism is detached from, so that movable member and dosage Component rotates freely relative to each other, and driving assembly is switched to batch operation mode.According to this embodiment, user can be with It introduces batch operation or distributes the drug of setting dosage by manipulation dose.Preferably, driving assembly is constructed such that, When user has been distally moved dose and he keeps distad pressing dose, user passes through identical movement From the dosage of device distribution setting.
In one embodiment, driving assembly is constructed such that, when movable member is in dose setting position, deposits It stores up the energy in spring member and is used to driving gigback and drive feedback mechanism, which can operate to work as and divide Visual, audible and/or tactile feedback is generated when dosing.Feedback mechanism can be distribution click acoustical generator mechanism.
In one embodiment, feedback mechanism is formed by movable member and dose.During dosage distribution, machine is fed back Structure can mainly provide audible feedback, inform that user is distributing drug.Thus, for example, the flexibility provided by movable mechanism Arm and by dose provide engaging section the audible feedback can be provided.Movable member and dosage structure can be only allowed in Relative rotation in one relative direction of part.Feedback mechanism can be configured to the drug for each unit distributed from device The audible click sound of single is provided.
In one embodiment, driving assembly includes further feedback mechanism.Further feedback mechanism can be setting Click acoustical generator mechanism.Further feedback mechanism can be formed with protrusion mentioned above, when it crosses over complementary clutch knot When the spline structure of structure, it provides visual, audible and/or tactile feedback.According to this embodiment, because the dosage of setting increases As soon as such as the drug of unit, provide the user with primary feedback, it is possible to realize the safety operation of medicine delivery device.
In one embodiment, driving assembly includes display member, wherein display member relative to shell by spin locking, and And wherein, when movable member is moved to dose setting position from initial position, the mobile axial distance of display member is greater than The mobile axial distance of dose.This provides the advantages of operability for increasing driving assembly or medicine delivery device.Because The manual dexterity of user is restricted, so the shorter axial stroke of dose and in this way smaller device Length be it is desired, therefore, can more easily operating device.However, under given conditions, the mobile distance of display member It can need the label more greatly to allow to can be seen that indicating member by display member window.The advantages of as preceding embodiment, The mobile axial distance of dose keeps very little, and therefore, the axial length of medicine delivery device can also keep very little, And the axial distance of display member movement is advantageously larger.
In one embodiment, driving assembly includes indicating member.By providing display member and indicating member, can make During the operation of medicine delivery device dosage information can be indicated to the user that in user friendly and safe mode.
In one embodiment, display member includes display member window.Dosage information can be aobvious by display member window Show to user.
In one embodiment, indicating member includes label.The label can be around the outer surface of indicating member at spiral Arrange to shape.Preferably, label provides dosage information, the unit or quantity of the drug such as distributed from medicine delivery device.
In one embodiment, indicating member and display member have sleeve-shaped shape.In this way, indicating member can be with A large amount of labels are provided.In addition, indicating member can be at least partly retained in display member.
In one embodiment, driving assembly is constructed such that, during the operation of driving assembly, display member relative to Indicating member axially moves, so that different labels is visible by display member window.Therefore, label can be by user Identification.Driving assembly is preferably configured so that, during the operation of medicine delivery device, display member can be relative to instruction Component axially moves.In addition, label can be disposed on indicating member, so that only one label passes through display member every time It is visible, thereby indicates that the dosage for actually setting or distributing, that is, the actual dose state of device.
In one embodiment, display member is relative to shell by spin locking.This is provided an advantage in that by relative to example Display member window as shell is in constant rotation position can be with the actual dose state of instruction device.In turn, this is meaned , user can be easy and reproducible the dosage information for identifying medicine delivery device.
In one embodiment, dose includes inner segment.Driving assembly is constructed such that, when movable member is in agent When measuring in position, the proximal section of display member is maintained in inner segment.The advantages of as the embodiment, even if in the setting of dosage The mobile axial distance of period display member is more than a mobile axial distance in dose, the proximal section of display member It can also be accommodated by inner segment.
In one embodiment, driving assembly is constructed such that, when movable member is in initial position, proximal section It is arranged in the outside of inner segment.
In one embodiment, the induction element of driving assembly includes the first thread segment with the first lead and has second Second thread segment of lead, wherein the second lead is greater than the first lead.The embodiment allows: such as having when the component couples When being threadedly coupled to guiding elements to body, the component for being threadedly coupled to induction element can move different axial distances.Guidance Element can be drive member or can be provided by drive member.
In one embodiment, driving assembly includes final dose component, which can operate when dosage increases Added-time is mobile from starting position towards end position.Therefore, when earlier set or increased dosage reduce, final dose can be made Component is mobile from end position towards starting position.Final dose component is configured to be arranged in starting position when final dose component In or close to starting position when interact with the first thread segment.Therefore, opposite between final dose component and induction element Axial movement is determined by the first lead.
In one embodiment, final dose component is configured to be arranged in end position or lean on when final dose component It interacts when nearly starting position with the second thread segment.Term " close " beginning and end position will indicate final dose component Position, in this position, final dose component engage the first and second thread segments respectively.
According to this embodiment, it is achieved that working as final dose component because the second lead is greater than the first lead It is arranged in end position or when close to end position, in the case where induction element is rotated relative to final dose component, end The mobile bigger axial distance of secondary dose.
In one embodiment, final dose component is configured to threadingly engage the first thread segment and the second thread segment.Cause This, it is achieved that when set doses drug when, final dose component can with the first thread segment and the second spiral shell Line section is threadedly engaged.Depending on the relative position of final dose component and induction element, therefore final dose component can engage First or second thread segment so that axial distance that final dose component is mobile relative to induction element (axial distance by First and second leads determine) also by position determines to axial described in final dose component and guiding elements.
First thread segment can be with the distal thread section of induction element.Second thread segment can be the proximal thread of induction element Section.
In one embodiment, drive member includes drive member stop configurations.Rotary-drive member stop part can be by driving Dynamic component stop configurations limit.
In one embodiment, final dose component includes final dose stop configurations.Dose component stop part can be with It is limited by final dose stop configurations.
In one embodiment, final dose stop configurations are configured to when final dose component and the second thread segment phase interaction Used time and drive member stop configurations are formed together rotation stopper section, so that preventing further increasing for setting dosage.Preferably, When final dose component is arranged in end part, drive member stop configurations and final dose stop configurations are against so that anti- Only setting dosage further increases.
Term " lead " is related to the axial distance that a component is moved when rotating single-turn, and the movement of the component is by corresponding Screw thread limits.
Term " pitch " is related to the axial distance between adjacent screw thread route or winding.For single thread, pitch It is identical as lead.
In one embodiment, the first thread segment and the second thread segment are single thread sections.This provide an advantage in that with it is for example more Head thread section is compared, and for given pitch, lead is smaller.
In one embodiment, the overall diameter of the second thread segment is greater than the overall diameter of the first thread segment.First thread segment and The interior or minor diameter of two thread segments is preferably identical.The embodiment allows thread segment and different internal screw threads (such as last The screw thread of secondary dose) it engages.
In one embodiment, the axially-extending portion of final dose stop configurations is greater than the pitch or lead of the first thread segment, And less than the pitch of the second thread segment.As advantage, rotation stop can be configured to quite big and firm.Specifically, institute State rotation stop configurations relative to axially-extending portion against or contact length can be implemented as the pitch than the first thread segment It is bigger.This allows the firmer construction of the rotation stop, wherein when final dose component is arranged in end position When, further increasing for setting dosage can be reliably prevented.Preferably, the axially-extending portion of drive member stop configurations is also big In the pitch of the first thread segment, and less than the pitch of the second thread segment.
In one embodiment, final dose component is rotatably locked relative to shell.According to this embodiment, Ke Yishi Existing, when setting drug dose, especially when dosage increases or dosage reduces, final dose component is relative to driving structure Part is advanced.
In one embodiment, drive member is axially constrained relative to movable member.During the distribution of dosage, bullet Spring component is intended to rotate movable member towards its initial position along the threaded connection of itself and shell.Due to moving structure Axial constraint between part and drive member, at least to a certain extent, when the medicine from medicine delivery device distribution doses When object, movable member drives drive member or is distally moved actuator.On this point, spring member activates driving machine Structure facilitates auxiliary drive mechanism, which separates with mentioned driving mechanism.The proximal side of drive member and can The distal face of mobile member can be against during the distribution of dosage.During the setting of dosage, in the described close of drive member There may be edge clearance between side and the distal face of movable member.
In one embodiment, the first end of spring member is connected to shell, and the second end of spring member is connected to instruction The distal end of component.According to this embodiment, especially for the design of compact and simple device, the general utility functions of driving assembly It can be realized with the means of most convenient.
In one embodiment, movable member is rotatably locked relative to indicating member.Therefore, it is accomplished that, The rotation of indicating member is passed to movable member during the operation of device, and vice versa.According to this embodiment, especially For compact and simple device design, the general utility functions of driving assembly can be realized with the means of most convenient.
In one embodiment, piston rod includes the first helicitic texture, the driving spiral shell of first helicitic texture and drive member Line structure matches.Through the first helicitic texture and driving helicitic texture, piston rod and drive member it is preferably coupled so that, driving Component can be turned relative to the distal side mobile (this distal side movement can generate during the distribution or conveying of dosage) of shell Rotation and the distal side for changing piston rod into are mobile.
In one embodiment, piston rod includes the second helicitic texture, which matches shell helicitic texture, In the shell screw thread, the overlapping of the first and second helicitic textures or fusion.According to this embodiment, piston rod can be threadedly coupled simultaneously To housing parts, it is preferably threaded into inner housing and drive member.Pass through the first and second helicitic textures of piston rod Fusion constructs, piston rod respectively may be axially be overlapped with the range that shell and drive member threadably interact, and make The compact design of driving assembly or design must may be implemented.
Since final dose component can be configured to double thread, so as to the first and second thread segment phase interactions With so being filled with the drug conveying for not including such final dose component and the induction element with the first and second thread segments Corresponding component is compared in setting, and final dose component occupies shorter axial length.Therefore, so that in the length for not increasing device In the case where, the medicament cylindrantherae of such as larger capacity can be used.
In one embodiment, driving assembly is constructed such that, when administered, the first and second helicitic textures are led The ratio of journey limits the mechanical advantage between the axial movement of drive member and the axial movement of piston rod.Mechanical advantage passes through the One and second the sum of the lead of helicitic texture calculated divided by the lead of the second helicitic texture.The mechanical advantage may relate to The distance and piston rod that drive member is axially moved relative to shell during the distribution of dosage are distally moved relative to shell Axial distance.The mechanical advantage can take the value of such as 2:1 or 3:1.
The concept of the driving assembly proposed allows the embodiment of medicine delivery device, wherein for given setting agent Amount, the axial stroke of dose is fairly small.This is because from movable member and referring to during the distribution of dosage Show that the frictional force of the movement of component can such as expand by the spring force or spring torque of spring member, so that being applied by user The driving force added can be used to through drive member and piston rod directly drive driving mechanism, not need user's power and be applied to screw thread to connect Mouth is to generate torque so that display component component returns.Therefore, being threadedly engaged between movable member and inner housing can be by Fairly small lead is provided, thus especially set maximum can setting dosage in the state of, the axial direction of medicine delivery device is long Degree can keep very little.In turn, the lesser axial length of medicine delivery device causes the increased of medicine delivery device can Operational and improved ergonomic design.
Term " drug " used herein or " pharmaceutical substance " mean the medicine containing at least one pharmaceutically active compound Object preparaton,
Wherein in one embodiment, the pharmaceutically active compound have up to the molecular weight of 1500Da and/or Person is that peptide, protein, polysaccharide, vaccine, DNA, RNA, enzyme, antibody or its segment, hormone or oligonucleotides or above-mentioned pharmacy are living The mixture of property compound,
Wherein in a further embodiment, the pharmaceutically active compound for treat and/or prevent diabetes or with The related complication of diabetes, such as diabetic retinopathy (diabetic retinopathy), thromboembolic disorders (thromboembolism disorders) such as Deep venou or pulmonary thromboembolism, acute coronary syndrome (acute Coronary syndrome, ACS), it is angina pectoris, myocardial infarction, cancer, macular degeneration (macular degeneration), scorching Disease, hay fever, atherosclerosis and/or rheumatoid arthritis be it is useful,
Wherein in a further embodiment, the pharmaceutically active compound includes at least one for treatment and/or pre- The peptide of anti-diabetes or complication related with diabetes (such as diabetic retinopathy),
Wherein in a further embodiment, the pharmaceutically active compound includes at least one actrapid monotard or people's pancreas islet Plain analog or derivative, glucagon-like peptide (glucagon-like peptide, GLP-1) or its analog or derivative Object or Exendin -3 (exedin-3) or exendin-4 (exedin-4) or Exendin -3 or exendin The analog or derivative of peptide -4.
Insulin analog such as Gly (A21), Arg (B31), Arg (B32) actrapid monotard；Lys (B3), Glu (B29) people Insulin；Lys (B28), Pro (B29) actrapid monotard；Asp (B28) actrapid monotard；Actrapid monotard, wherein B28 proline It is replaced by Asp, Lys, Leu, Val or Ala and wherein B29 lysine could alternatively be Pro；Ala (B26) people's pancreas islet Element；Des (B28-B30) actrapid monotard；Des (B27) actrapid monotard；With Des (B30) actrapid monotard.
Insulin derivates such as B29-N- myristoyl-des (B30) actrapid monotard；B29-N- palmityl-des (B30) Actrapid monotard；B29-N- myristoyl human insulin；B29-N- palmitoyl human insulin；B28-N- myristoyl Lispro；B28-N- palmityl-Lispro；B30-N- myristoyl- ThrB29LysB30 actrapid monotard；B30-N- palmityl-ThrB29LysB30 actrapid monotard；B29-N- (N- palmityl-Υ-paddy Aminoacyl)-des (B30) actrapid monotard；B29-N- (N- stone gallbladder acyl-Υ-glutamy)-des (B30) actrapid monotard；B29-N-(ω- Carboxyl heptadecanoyl)-des (B30) actrapid monotard and B29-N- (ω-carboxyl heptadecanoyl) actrapid monotard.
Exendin-4 means such as exendin-4 (1-39), is the peptide with following sequences: H His- Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg- Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pr o-Pro-Ser- NH2。
Exendin-4 derivative is for example selected from following compound lists:
H- (Lys) 4-des Pro36, des Pro37 exendin-4 (1-39)-NH2,
H- (Lys) 5-des Pro36, des Pro37 exendin-4 (1-39)-NH2,
Wherein-Lys6-NH2 group can be incorporated into the C-terminal of exendin-4 derivative；
Or the exendin-4 derivative of following sequences
H- (Lys) 6-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H-Asn- (Glu) 5-des Pro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1- 39)-(Lys)6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
Des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (1-39)- (Lys)6-NH2,
H- (Lys) 6-des Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (S1-39)-(Lys)6-NH2,
Or the pharmaceutically acceptable salt or solvate of aforementioned any exendin-4 derivative.
Pituitrin (the hypophysis that hormone is for example listed in Rote Liste, ed.2008, the 50th chapter ) or hypothalamic hormone (hypothalamus hormones) or modulability active peptide (regulatory active hormones Peptides) and their antagonist, such as promoting sexual gland hormone (follitropic hormone (Follitropin), metakentrin (Lutropin), human chorionic gonadtropin (Choriongonadotropin), Menotrophins (Menotropin)), Somatropine (growth hormone (Somatropin)), minirin (Desmopressin), terlipressin (Terlipressin), Gonadorelin (Gonadorelin), Triptorelin (Triptorelin), Leuprorelin (Leuprorelin), Buserelin (Buserelin), nafarelin (Nafarelin), Goserelin (Goserelin).
Polysaccharide such as glucosaminoglycan (glucosaminoglycane), hyaluronic acid (hyaluronic acid), liver The sulphation of element, low molecular weight heparin or ultra-low molecular weight heparin or derivatives thereof or aforementioned polysaccharide, such as poly-sulfated shape Formula and/or its pharmaceutically acceptable salt.One example of the pharmaceutically acceptable salt of poly-sulfated low molecular weight heparin is according to promise liver Plain sodium (enoxaparin sodium).
Antibody is spherical plasma proteins (~150kDa), also referred to as immunoglobulin, shares a kind of foundation structure.Cause There is the sugar chain for being added to amino acid residue for them, so they are glycoprotein.The basic function unit of each antibody is to exempt from Epidemic disease globulin (Ig) monomer (only contains an Ig unit)；The antibody of secretion be also possible to tool there are two Ig unit dimer such as There are five the five poly- of Ig unit there are four the IgM of the tetramer such as bony fish (teleost fish) of Ig unit or tool for IgA, tool The IgM of body such as mammal.
Ig monomer is Y-shaped molecule, is made of four polypeptide chains；Two identical heavy chains and two identical light chains, They pass through the disulfide bond connection between cysteine residues.Each heavy chain is about 440 amino acid；Every light chain is about 220 A amino acid.Each heavy chain and light chain contain intrachain disulfide bond, and intrachain disulfide bond stablizes their folding.Every chain is all by claiming It is constituted for the structural domain in the domain Ig.About 70-110 amino acid is contained in these domains, and is returned according to their size and function classification Enter different scopes (for example, variable or V, constant or C).They have characteristic immunoglobulin folding, two of them β piece Layer creates a kind of " sandwich " shape, and the shape is by the phase interaction between conservative cysteine and other electrically charged amino acid With and keep together.
There are five types of types for mammal Ig heavy chain, are expressed as α, δ, ε, γ and μ.The type of existing heavy chain determines antibody Isotype；These chains can be found in IgA, IgD, IgE, IgG and IgM antibody respectively.
The size and composition of different heavy chains are different；α and γ contains about 450 amino acid, and δ contains about 500 A amino acid, and μ and ε has about 550 amino acid.There are two areas, i.e. constant region (CH) and variable region for each heavy chain tool (VH).In a species, constant region is substantially the same in all antibody of same isotype, but different of the same race It is different in the antibody of type.Heavy chain γ, α and δ have constant region and strand for increased flexibility comprising three domains Ig of connecting Sequence；Heavy chain μ and ε have the constant region comprising four immunoglobulin domains.The variable region of heavy chain is being generated by different B cells It is different in antibody, but it is identical for all antibody generated by single B cell or single B cell clone. The variable region of each heavy chain is about 110 amino acid longs and includes the single domain Ig.
In mammals, there are two types of the light chain immunoglobulin of type, λ and κ are expressed as.There are two continuous for light chain tool Domain a: constant domain (CL) and a variable domain (VL).Light chain grows about 211 to 217 amino acid.Each antibody contains two Light chain, they are always the same；There is only a type of light chain κ or λ for each antibody in mammals.
As detailed above, although the general structure of all antibody is closely similar, the peculiar property of given antibody is It is determined by variable area (V).More specifically, variable loop -- there are three it is each on light chain (VL) and on heavy chain (VH) -- is responsible for In conjunction with antigen, i.e. antigentic specificity.These rings are referred to as complementary determining region (Complementarity Determining Regions, CDRs).It is heavy chain and light chain because the CDR from the domain VH and VL contributes antigen binding site Combination is rather than a single one determine final antigentic specificity.
" antibody fragment " contains at least one antigen-binding fragment as defined above, and presents complete with derivative antibody fragment Whole antibody substantially the same function and specificity.It is with papain (papain) restrictive proteolytic digestion that Ig is former Type is cracked into three segments.Two identical amino-terminal fragments are antigen-binding fragment (Fab), each segment contain one it is complete Whole L chain and approximately half of H chain.The third fragment is crystallizable fragment (Fc) that is similar in size but include is two heavy chains The half of carboxyl terminal, and have interchain disulfide bond.Fc contains sugar, complement-binding site and FcR binding site.It is restricted Pepsin (pepsin) digestion generate 2 segment of single F (ab') containing two Fab and hinge area comprising H-H interchain Disulfide bond.F (ab') 2 is divalent for antigen binding.The disulfide bond of F (ab') 2 can be cracked to obtain Fab'.This Outside, the variable region of heavy chain and light chain can be fused together to form single chain variable fragment (scFv).
Pharmaceutically acceptable salt such as acid-addition salts and basic salt.Acid-addition salts such as HCl or HBr salt.Basic salt for example has There are the cation selected from alkali or alkaline earth, such as the salt of Na+ or K+ or Ca2+ or ammonium ion N+ (R1) (R2) (R3) (R4), Middle R1 to R4 is independently of one another are as follows: hydrogen, the C1-C6 alkyl optionally replaced, the C2-C6 alkenyl optionally replaced, the C6- optionally replaced C10 aryl or the C6-C10 heteroaryl optionally replaced.More examples of pharmaceutically acceptable salt are in " Remington's Pharmaceutical Sciences"17.ed.Alfonso R.Gennaro(Ed.),Mark Publishing Company, It is described in Easton, Pa., U.S.A., 1985 and in Encyclopedia of Pharmaceutical Technology.
Pharmaceutical acceptable solvents close object such as hydrate.
Context combines feature described in different aspect or embodiment to be readily applicable to other aspects and reality Apply example.The further feature and benefit of the theme of the disclosure will become from the following description for the exemplary embodiment for combining figure Obviously, in which:
Fig. 1 is with the medicine delivery device component shown in exploded view.
Fig. 2 shows the side views of medicine delivery device.
Fig. 3 shows the longitudinal section of the component of the driving mechanism of medicine delivery device.
Fig. 4 shows the partial longitudinal section figure of the component of medicine delivery device.
Fig. 5 shows the sectional view of medicine delivery device.
Fig. 6 shows the side view of the component of the display component of medicine delivery device.
The different states of the display component of medicine delivery device are shown respectively in Fig. 7 A-C.
Fig. 8 shows the partial longitudinal section figure of the component of the driving mechanism of medicine delivery device.
Fig. 9 shows the partial longitudinal section figure of the inner part of medicine delivery device.
The perspective view of the component of medicine delivery device is shown respectively in Figure 10 A-C, wherein shows medicine delivery device not Same state.
Figure 11 shows the perspective view of the indicating member of medicine delivery device.
Figure 12 shows the perspective view of the display member of medicine delivery device.
The local perspective view of the component of medicine delivery device is shown respectively in Figure 13 A-C.
Figure 14 shows the side view of the final dose component of medicine delivery device and the part of drive member.
Figure 15 shows the longitudinal section of the final dose component of medicine delivery device.
The element and identical functional element of similar element, identical type can be provided identical in the graphic Appended drawing reference.In addition, figure may not be true ratio.On the contrary, certain features may be painted in exaggerated form so as to more Important principle is illustrated well.
As shown in Figure 1, medicine delivery device includes shell 10.Shell 10 may be constructed the outer master of medicine delivery device 100 Body.Shell 10 includes longitudinal axis, which can be with longitudinal axis x (referring to Fig. 2) weight of medicine delivery device 100 It closes.Medicine delivery device 100 further includes label 121, which can adhere to the outer surface of shell 10.Label 121 can be with Including hole, when label 121 is adhered to shell 10, which can limit shell window 123.In a preferred embodiment In, outer housing 10 is transparent.Preferably, label 121 is opaque.
In fig. 2 it is shown that label 121 covers the major part of shell 10, other than window 123.Outer casing section 10 It is tube elements in general with distal part and portions of proximal, forms cylindrantherae bracket for receiving cylindrantherae 80.
Medicine delivery device 100 further includes interior main body 20, piston rod 30, driver 40, nut 50, indicating member 60 and medicine Cylinder 80.Medicine delivery device 100 may include additional component, such as the needle device including needle stand and needle housing.
Medicine delivery device 100 further includes the first button part 70a, after assembling medicine delivery device 100, preferably will First button part 70a is rigidly affixed to the second button part 70b to form the button 70 of medicine delivery device 100 (ginseng Examine Fig. 1).Hereinafter, when being related to button 70, it is related to being rigidly connected to mutual two components (70a and 70b).When relating to And when dose, it is also possible to be related to button.Because identical component is it is meant that identical appended drawing reference is used for button and dosage Component.Dose can be button.
Button 70 can have the surface for allowing user easily to grasp button 70.
Interior main body 20 is the generally cylindrical element with different diameter regions.When being related to inner housing, it is also possible to be related to Interior main body.Because identical component is it is meant that identical appended drawing reference is used for interior main body and inner housing.Inner housing can be interior master Body.
As for example seen in Fig. 3, interior main body 20 be accepted in the housing 10 and be permanently attached to wherein to prevent Only any relative movement of the interior main body 20 relative to shell 10.External screw thread 21 is arranged on the outer surface of interior main body 20.In addition, flower Key 22 is arranged on the inner surface of interior main body 20, such as spline 22 is shown in FIG. 5.As from figs. 3 and 4 it can be seen that interior master Body 20 has internal screw thread 23 close to its far-end.
Piston rod 30 is that there are two the elongated members of external screw thread (being not explicitly indicated) (opposite side overlaps each other or merges) for tool. The internal screw thread 23 of an engagement interior main body 20 in these screw threads.Medicine delivery device further includes bearing 31.As shown in Figure 3, When medicine delivery device 100 is in assembled state, bearing 31 can interact with piston rod.Bearing 31 and piston rod 30 Separation, so that bearing 31 keeps seated connection to allow the opposite rotation between bearing 31 and piston rod 30 on the distal end of piston rod 30 Turn.
Driver 40 is the generally cylindrical element with different-diameter region.When being related to drive member, it is also possible to be related to Driver.Because identical component is it is meant that identical appended drawing reference is used for drive member and driver.Drive member can be Driver.Driver 40 is for example rotationally locked to button 70 through corresponding spline joint portion.
The distal region of driver 40 has external screw thread 46, as that will be outlined below.The inner surface of driver 40 has There is one in the external screw thread of engaging piston bar 30 internal screw thread (being not explicitly indicated).Driver 40 is around piston rod 30 and works as Device 100 is located in interior main body 20 when being assembled (with reference to Fig. 3).Driver 40 has proximal open, will in further detail below Explain the proximal open in ground.In addition, the U-shaped notch in the skirt section that resilient finger-shaped member 44 passes through driver 40 is arranged in driver 40 On, as shown in fig. 1.Finger 44 is allowed to bend and engage 70 (see below) of button in the axial direction.In addition, soft Property hinged protrusion 45 (referring to Fig. 8) be arranged by the similar notch in the skirt section of driver 40 in driver 40 On.Protrusion 45 can form or help the function of clutch configuration.Protrusion 45 is allowed radially-inwardly to bend.Protrusion 45 engages interior master The spline 22 of body 20.Spline 22 may be constructed complementary clutch configuration.In addition, protrusion 45 and spline 22 form click acoustical generator Assembly, when setting or switch dosage, which provides a user palpable and audible feedback.The click Acoustical generator assembly of rattling away has the function of further below: when switch, click acoustical generator assembly limits indicating member 60 Discrete location, and the method that the rotation of locking driver 40 is provided and therefore locks the rotation of dose 70.The function Property can be provided by releasable clutch mechanism, which is constructed such that, under setting operation mode, Dose 70 is rotatable relative to shell, and under batch operation mode, clutch configuration and complementary clutch configuration phase Interaction, so that dose 70 is relative to shell 10 by spin locking.During switch, button 70 relative to driver 40 at In axial position, so that recess or recess portion 73 are located at the radially inner side of protrusion 45.Therefore, allow protrusion 45 radially-inwardly bend with Spline 22 is overcome, to provide a user palpable and audible feedback.
Nut 50 is arranged between interior main body 20 and driver 40.When being related to final dose component, nut may relate to. Because identical component is it is meant that identical appended drawing reference is used for final dose component and nut.Final dose component can be Nut.
The external fin 58 of nut 50 engages the spline 22 of inner housing 20.The internal screw thread 55 of nut 50 engages the outer spiral shell of driver 40 Line 46.In addition, in the embodiment of figure 14, four rotation final dose stop configurations 54 be arranged on nut 50 so as to driving Corresponding drive member stop configurations 48 interaction on device 40.
Indicating member 60 is substantially tube elements.Indicating member 60 is preferably rotatable but is stopped relative to inner housing by corresponding Block piece axially constrains.Indicating member 60 is placed between interior main body 20 and shell 10.It is arranged on the outer surface of indicating member 60 (such as printing) has a series of labels 66, such as provides the number of dosage information.Number arrangement is on helix, so that passing through window Mouthfuls 123 every time it can be seen that only one is digital or only several numbers.
The sleeve-shaped portion 72 of button 70 with reduced diameter extends in a distal direction and is inserted into driver In 40, limited relative axial movement is allow, but prevents relative rotation.Such case passes through pair in sleeve-shaped portion 72 The structure answered realizes that the corresponding structure is guided in the proximal open (being not explicitly indicated) of driver 40.It is general and It says in the sleeve-like parts 72 (with reference to Fig. 8) that there is the recess portion 73 of the profile of protrusion 45 button 70 is arranged in.
Medicine delivery device 100 further includes the first movable member part 110a, assembly medicine delivery device 100 it Afterwards, the first movable member part 110a is preferably rigidly affixed to the second movable member part 110b to form drug The movable member 110 (referring to Fig. 1) of conveying device 100.Hereinafter, when being related to movable member 110, it is related to rigidly It is connected to mutual two components (110a and 110b).Movable member 110 has sleeve-shaped shape, and longitudinal axis is in device Assembled state under can be overlapped with the longitudinal axis x of medicine delivery device 100.
Two unit embodiments of dose 110 and button 70 and other component cooperation can contribute to be easy assembly medicine Object conveying device 100.
Medicine delivery device 100 further includes display member 120.Display member 120 includes display member window 122.Work as medicine When object conveying device 100 is assembled, movable member 110 can be received partly by display member 120.Display member 120 is excellent Selection of land is relative to shell 10 by spin locking.Movable member 110 is at least partly received by display member 120.
Medicine delivery device 100 further includes spring member 130 (with reference to Fig. 1).Spring member 130 is preferably attached to inner housing 20 and indicating member 60.Alternatively, spring member 130 may be coupled to other component.
Movable member 110 is revolved through movable member spline 128 and indicating member spline 131 relative to indicating member 60 Twist lock is fixed (referring to Figure 13).Movable member 110 through movable member screw thread and distal member screw thread (with reference in Fig. 8 124, 125) further it is threadedly coupled to display member 120.
Releasable rotary locking mechanism is arranged by corresponding locking teeth 114 and 74 (referring to Fig. 8) in movable member Between 110 and dose 70.If the tooth 74 of button 70 engages the locking teeth 114 of movable member 110, button 70 and can Mobile member 110 is by spin locking.The resilient finger-shaped member 44 of driver 40 makes button 70 along the proximal direction of device 100 (that is, edge Engage the direction of locking teeth 74,114) it is biased.In this case, medicine delivery device is under setting operation mode, In, movable member 110 and dose 70 are by by spin locking.
Releasable rotary locking mechanism can be released, to allow by referring to button 70 relative to the resistance of shell 10 It shifts and relative rotation to the bias axial of shape part 44, so that medicine delivery device 100 be grasped from setting pattern switching to distribution Operation mode.
In addition, on the movable member 110 and inside of button 70 is arranged in by flexible arm 65 in distribution click acoustical generator In flank profil.
Fig. 2 shows medicine delivery device 1 in the form of injection pen.Device has distal end 16 and proximal end 17.
In Fig. 2, label 66, specifically digital " 0 " passes through display member window 122 and shell by medicine delivery device 100 Body window 123 is painted.In Fig. 2, medicine delivery device is in original state, in this state, distributes zero-dose or not yet divides Dosing.Original state can refer to the assembled state (as-assembled state) of device.In this state, it moves Component 110, display member 120 and indicating member 60 are preferably in initial position.When a dose is to be set, the component is preferably located In dose setting position.
In Fig. 2, mentioned label 66 is shown as in the distal end of shell window 123.Display member window 122 is close Side is limited by the color segment 64 of display member 120.The color segment may include the first color, such as, for example (,) it is red.Further Color segment it is (not shown in FIG. 2；Compare 67 in Fig. 7 C) it can be in distal side limitation or adjacent display member window 122.
Medicine delivery device 100 is preferably configured so that, for setting dosage, user must make dose 70 opposite It is rotated in a first direction in shell 10, wherein dose 70 is mobile in nearside also relative to shell 10.Preferably, drug is defeated When device 100 being sent to be constructed such that the drug of proper setting doses, display structure window 122 is in shell window 123 from Fig. 2 Shown in position start to nearside advance.Reset or cancellation to earlier set dosage can be executed by user, because of user Rotate in the second direction opposite to the first direction dose 70 relative to shell 10.Preferably, can with zero with it is pre- Determine the predetermined increment setting between maximum dose and resets any drug dose size.
Medicine delivery device 100 can be further configured so that, in order to convey the dosage of earlier set, user is necessary It manually squeezes dose 70 or deviates dose 70 distad relative to shell 10.
Medicine delivery device 100 includes driving assembly, which further includes driving mechanism and gigback.Driving machine Structure may include or be related to piston rod 30 and drive member 40.Gigback may include or be related to spring member 130.
Medicine delivery device 100 further includes display component, which may include or be related to display member, indicate structure Part and movable member.Display component can further include shell, which may be constructed the shell 10 of medicine delivery device 100.
Fig. 3 shows the partial longitudinal section of medicine delivery device 100, is painted the component of driving mechanism and gigback (in addition Compare Fig. 8).
In Fig. 3, medicine delivery device 100 is in the following state: no administered is assigned with zero-dose, and solid Hold in cylindrantherae 80 tube plug or piston 82 be arranged in cylindrantherae 80 nearest side at.Cylindrantherae 80 includes that pre-filled constriction cylindrantherae is deposited Storage portion 81, the storage unit 81 can usually be made of glass.Pierceable rubber seal (not shown) is located in another distal side End.Rubber seal is kept in place using crimping endless metal belt 83.Cylindrantherae 80 is arranged in shell 10, piston rod 30 and bearing 31 against tube plug 82.
In Fig. 3, the component of device 100 preferably at least partly surrounds the longitudinal axis x of medicine delivery device 100 in Heart arrangement.Movable member 110 and also indicating member 120 are arranged in initial position.In addition, final dose component 50 It is in its farthest position relative to drive member 40, indicates user's not yet setting dosage and not yet from device administered.
Indicating member 60 preferably axially is constrained to interior main body 20, so that indicating member 60 is preferably only in medicine delivery device It rotates during 100 operation, and does not move axially.The operation of device 100 may include the setting and distribution of dosage.
Spring member 130 is preferably torsion spring.Preferably, gigback includes spring member 130.
Fig. 4 illustrates in greater detail the section of the medicine delivery device 100 of Fig. 3, to show the position of elastic component 130. Spring member 130 is distally connected to inner housing 20, and the proximal end of spring member 130 is connected to indicating member 60.
Fig. 5 shows the sectional view of medicine delivery device 100.During the setting of dosage, dose 70 is relative to shell 10 are rotated in a first direction with movable member 110, drive member 40 and indicating member 60.110 screw thread of movable member connects It is connected to inner housing 20, so that it is also mobile to nearside relative to shell during the setting of dosage.As indicating member 60 is opposite It is rotated in shell, spring member 130 is biased.Preferably, the quilt under the original state of indicating member 60 of spring member 130 Biasing.
When being incremented by setting dosage, the torque of spring member 130 must be overcome by user.When dose 70 rotation and Under setting operation mode when setting dosage, the torque must pass through the spline interface between drive member 40 and interior main body 20 (with reference to spline 22 and protrusion 45) reaction.The internal spline 22 that the interface is arranged and is constructed such that in interior main body 20 Geometry biased, to compensate nominal spring member torque, so that increase and setting dosage about setting dosage The torque of decline can be balanced or compensate, because torque needed for changing setting dosage is the spring for overcoming spring member 130 The torque of power and the sum of the torque for overcoming spline interface, when being incremented by setting dosage, the spring force of spring member 130 is just , when reducing setting dosage, the spring force of spring member 130 is negative.
The slightly biased shifting of spline bevel angle of the spline 22 of interior main body 20 and protrusion 45 in drive member 40, to compensate in agent The influence of the spring torque of spring member 130 during the setting of amount, so that overcoming needed for spline interface when reducing setting dosage Torque ratio increase setting dosage when it is bigger.
Alternatively, the spline interface between spline 22 and protrusion 45 can be configured to symmetrically increased or decrease to work as Identical pulleying torque is provided when setting dosage.Therefore, spring member can be constructed such that and change medicine delivery device Setting dosage typical user's moment of torsion ratio, torque can be considered as small.
In Fig. 6, compared with Fig. 2, display member 120 is not shown, so that label 66 specifically indicates the quantity of drug Number shown by shell window 123.Close to the distal end of shell window 123, " 0 " is indicated by window 123 by indicating member 60. Close to the proximal end of shell window 123, " 120 " are indicated by window 123 by indicating member 60.Digital " 120 " can be related to drug The maximum of conveying device 100 can setting dosage.
Shell window 123 can be lens shape, so that being amplified by the visible label 66 of shell window 123.Shell Body 10 can be transparent.Shell window 123 can also be formed by lens element (with reference to 11 in Fig. 5), and lens element can be with It is integrally formed by shell 10 and its ridge structure for forming shell 10.Label 121 can be arranged and be attached to shell 10, so that the lenticular element arrangement is in the above-mentioned hole of label 121.
When medicine delivery device is assembled, as shown in Figure 6, lens element 11 can be in the instruction for being disposed with label 66 Axially extend on the full axial length of component 60.Preferably, display member 120 is opaque, so that not corresponding to drug The label 66 of the present dose instruction of conveying device is shown component and shelters and cannot be recognized by the user.
The different conditions of the display component of medicine delivery device 100 are shown respectively in Fig. 7 A-C.Wherein, display member 120 fills It is fitted on device (compared with Fig. 6), so that only one label 66, preferably corresponds to the label of dosage currently set or distribution It is visible for a user.It is provided a user by the axial position of the visible display member window 122 of shell window 123 The visual instruction of the present dose state of device.The surface of display member 120 can also provide medicine delivery device 100 into one The dosage information of step.
In fig. 7, indicating member 60 and display member 120 are in the drug agent in initial position and setting 0 unit Amount, so that can be seen that " 0 " by display member window 122.Display member window 122 is in starting position.64 cloth of color segment It sets in nearside on 122 side of display member window.Color segment 64 may include red.Device 100 is preferably configured so that, when When setting dosage, display member window 122 is advanced in nearside, and at the same time, indicating member 60 is rotated relative to shell 10, so that Different labels 66 is shown by display member window 122.It therefore, is that the number of dose indicating quantity increases shown in fig. 7 Add.
In figure 7b, the dosage corresponding to the drug of four units or more is set, and passes through display member Window 122 shows " 4 ", and compared with Fig. 7 A, display member window 122 is slightly mobile to nearside.
In fig. 7 c, the maximum for setting the drug of 120 positions can setting dosage.In this case, display member window 122 are arranged at the position of its recent side relative to shell 10, that is, the end position of display member window 22.In addition, further Color segment 67 pass through and shown in shell window 123 of the nearside on the side of display member window 122.Further color segment 67 can To include green.
Fig. 8 shows the partial longitudinal section figure of the inner part of medicine delivery device 100.Wherein, for example, compared with Fig. 3, including The component of the driving assembly of driving mechanism and gigback illustrates in greater detail.It shows, movable member 110 includes removable Dynamic component screw thread 125, and display member includes the display member screw thread 124 to match with movable member screw thread 125.It is removable Component 110 further includes the internal screw thread 160 to match with the external screw thread 161 of inner housing 20.Preferably, the lead of screw thread 160,161 It limits or determines during the setting of dosage, the axial distance that dose is distally moved relative to shell is (with reference in Fig. 9 D)。
The protrusion 45 of drive member 40 is further shown in fig. 8.Axial movement of the display member 120 relative to shell 10 By threaded connection between movable member 110 and interior main body 20 (referring to screw thread 160,161) and display member 120 with Hickey (refer to screw thread 124,125) between movable member 110 and between display member 120 and movable member 110 Hickey (refer to screw thread 124,125) assembly and generate.Therefore, described to be threadedly engaged preferably so that in given dose Setting during be able to carry out display member 120 and axial moved than dose 70 relative to the corresponding of shell relative to shell 10 Dynamic bigger axial movement.
For this purpose, one turn of matched doses component 70, the total distance that display member 120 is axially advanced can be screw thread The sum of 124 and the screw pitch of screw thread 161.
In fig. 9, it shows the longitudinal section of the proximal end 17 of medicine delivery device 100.This illustrates medicine delivery device 100, wherein suitable strong dose object is set, because dose 70 is moved relative to shell 10 to nearside significantly It is dynamic.Compared with such as Fig. 8, the proximal segment of display member 120 is arranged in the inner segment 76 of dose 70.Because in setting for dosage The axial travel distance of display member 120 is greater than the axial travel distance of movable member 110 between periodically, so working as setting dosage When increase, display member 120 is gradually axially be overlapped with dose 70.In other words, during the setting of dosage, display member 120 are moved in inner segment 76, but two components (that is, display member 120 and dose 70) relative to shell 10 to nearside It is mobile.For this purpose, providing inner segment 76, the receiving to display member 120 is provided to set large dosage without increasing drug The overall length of conveying device 100.
The perspective view of medicine delivery device 100 is shown respectively in Figure 10 A-C, and wherein indicating member 60 is visible by shell 10 's.Figure 10 A is shown, without setting dosage, because can be seen that " 0 " by display member window 123.In fig. 1 ob, 20 are set The drug dose of a unit.In fig 1 oc, the maximum quantity of 120 units is set.But in this embodiment, 120 The quantity of unit correspond to maximum can setting dosage, medicine delivery device 100 also can be constructed such that, can set and The drug of more or less a units is distributed from medicine delivery device 100.
Figure 11 shows the perspective view of indicating member 60.Outer surface helically cloth of the label 66 around indicating member 60 It sets.It further shows, label 66 is across the range from the drug of 0 unit to the drug of 120 units.Indicating member 60 It further include minimum stop configurations 68 and maximum stop configurations 69, the minimum stop configurations 68 and maximum stop configurations 69 distinguish cloth It sets beside the label of instruction " 0 " and the label of instruction " 120 ", thus adjacent with the spirality path of label 66.
Figure 12 shows the perspective view of display member 120.It is provided with and is preferably attached with most on 122 periphery of indicating member window Low dose of stop configurations 126.At the side backwards to minimum dose stop configurations 126 of window 122, it is provided with and preferably adheres to There is maximum dosage backstop structure 127.Display member 120 further includes protrusion 129.The outer surface of protrusion 129 is preferably included into one The color segment 67 of step.The protrusion 129 is axially directed at display member window 122 relative to longitudinal axis x.
Minimum dose stop configurations 126 arrange and are configured to interact with minimum stop configurations 68, so that when not When having setting dosage, axial movement of the display member 120 relative to shell 10 along first axial direction is prevented.Therefore, structure is shown Part window 123 is arranged in starting position.
Maximum dosage backstop structure 127 is arranged and is configured to interact with maximum stop configurations 69, so that working as Setting maximum be when can set drug dose, prevent display member 120 relative to shell 10 along opposite with first axial direction the The axial movement of two axial directions.Therefore, display member window 123 is arranged in end position.
When do not have setting dosage or in this state when user attempt reduce dosage when, minimum dose structure 126 with most Small stop configurations 68 interact, and preferably abut against minimum stop configurations 68.When setting maximum can setting dosage or in this shape Under state when user is further intended to increase dosage, maximum dose structure 127 and maximum stop configurations 69 interact, preferably Against maximum stop configurations 69.The interaction can be for shown in Figure 13.
The relative position of the stop configurations (68,69,126,127) is limited in dosage setting and/or dosage batch operation The rotation of period indicating member 60 and the axial movement of display member 120.The stop part feature (68,69,126,127) point It can not formed by the prominent boss outstanding of the main body from indicating member 60 and display member 120 or shoulder.The stop configurations It is arranged and is constructed such that the label that can be restricted to by the dosage that medicine delivery device 100 is set on display member 60 66 range, the range correspond to can setting dosage range.
Zero and it is maximum can be in the Dose location between setting dosage, stop configurations 68,69 are led to below display member 120 The length section of indicating member 120 is crossed, is not provided with stop configurations in the length section.
By implementing the stop configurations (68,69,126,127), so that display member 120 and the direct phase of indicating member 60 Interaction can easily control the alignment of the label 66 shown by display component.
Indicating member 60 and display member 120 it is preferably very big against radius so that reaction force is small.
It can be maximized against length, because during the operation of medicine delivery device 100, the axis of display member 120 It is very big to stroke.
Figure 13 A-C further shows the mentioned backstop function between indicating member 60 and display member 120.Scheming In 13A, dosage, which (is not explicitly shown), in the drug of 99 units can be shown to user.In Figure 13 B, the drug of 119 units (being not explicitly shown) dosage can be shown to user.In Figure 13 C, the maximum of the drug (being not explicitly shown) of 120 units can Setting dosage can be shown to user.Here, maximum instruction stop configurations 69 and maximum display stop configurations 127 against.
In Figure 14, it is shown ... in a side view the final dose component 50 and distal segment of drive member 40.Final dose component 50 include final dose stop configurations 54.Final dose stop configurations 54 are configured to the drive member backstop with drive member 40 Structure 48 interacts.Final dose component 50 is threadedly coupled to the distal end of drive member 40.Therefore, drive member 40 includes the One external screw thread 46.Drive member 40 further includes the second external screw thread 47.Final dose component 50 includes with the first screw thread 46 (with reference to figure 15) the nearside internal screw thread 55 to match.Moreover, final dose component 50 includes matching with the second screw thread 47 (with reference to Figure 15) Distal side internal screw thread 56.The lead of second screw thread is greater than the lead of the first screw thread 46.The tooth root of first screw thread 46 and the second screw thread 47 Diameter is preferably equal.The overall diameter of second screw thread 47 is preferably greater than the first screw thread 46.First and/or second screw thread 46,47 Preferably one start screw.
Final dose component can be operated from when the medicine for then setting and distributing doses during the operation of device 100 Starting position is moved to end position when object.Starting position may relate to final dose component 50 in the far-end of drive member 40 Arrangement.End position may relate to the position of final dose component 50, in this position, final dose stop configurations 54 and drive Component stop configurations 48 are moved rotatably against so that rotation stop is formed, so that preventing further increasing for setting dosage.
In addition, final dose component 50 is by spin locking, but it is axial relative to inner housing 20 (being not shown in Figure 14) Ground moves.For this purpose, final dose component 50 includes rib 58, and when drive member 40 is rotated relative to shell 10, rib 58 It is axially guided by shell spline 22.
Preferably, the axially extending pitch for being greater than the first thread segment of dosage stop configurations or lead and less than the second screw thread The pitch of section.In Figure 14, the half way around of the second screw thread is only shown.But the pitch of the second screw thread can be by the second screw thread 47 Dual axially extending determination, as shown in Figure 14.
Figure 15 shows the longitudinal section of final dose component 50.Final dose component 50 includes recess portion 57.Distal thread 55 Pitch can be 0.7mm, and the pitch of proximal thread 56 can be 6mm.According to this embodiment, it is assumed that the medicine of 450 units The whole device length of the cylindrantherae capacity of object, medicine delivery device 100 can reduce 6.5mm.Mentioned number or value is nothing It is restrictive.Specifically, the length of device shortens due to being configured to single-threaded first screw thread 46.
According to the setting of the first and second screw threads, as mentioned, stop configurations 48 and 54 be may be implemented as more greatly, That is, having longer axially-extending portion.Therefore, the stability of final dose component 50 can increase.This is due to the following facts: As pitch increases, when moving final dose component 50 along nearside relative to drive member 40, the stop configurations can be with It is implemented as firmer.As final dose component 50 is mobile to nearside relative to drive member 40, such as setting in dosage Between periodically, in some time, final dose component is detached from from the first screw thread 46 and is joined to the second screw thread 47.
For the major part of the required rotation of the drive member 40 only occurred during dosage setting, the first screw thread 46 is led The axial stroke of process control final dose component 50.Preferably for during the setting of dosage drive member 40 it is last 180 ° of rotations, the second screw thread 47 control the axial stroke of final dose component 50.The embodiment of two different screw threads permits Perhaps the size and intensity for increasing stop configurations 48 and 54, so that stability is maintained.When setting dosage corresponds to residue in cylindrantherae Pharmaceutical quantities when, dose stop configurations 54 preferably abut against drive member stop configurations 48 so that prevent user setting more Big dosage.
As the alternative solution of mentioned embodiment, drive member 40 can also only include the (reference of single fine thread First screw thread 46), instead of the first and second mentioned screw threads.The embodiment allows to be substantially reduced in operation medicine delivery device The required axial space of the movement of 100 period final dose components 50.This reduction can be realized shorter single unit system length Or promote to accommodate the drug cartridge of larger capacity.
During the distribution of dosage, the movement institute by indicating member 60, movable member 110 and display member 120 is overcome Be related to or caused friction needed for can preferably by gigback (specifically by by biasing driving spring) consume.Furthermore Friction originating from distribution click acoustical generator mechanism as mentioned above is provided by gigback.During dosage distribution, point It is activation with click acoustical generator mechanism comprising button 70 and movable member 110.Click acoustical generator mechanism is distributed to user The substantially audible feedback for distributing drug is provided.The flank profil on flexible arm 65 and button 70 on movable member 110 Between interaction this distribution click sound is provided.The relative rotation being only allowed on a direction.Such case is when removable Dynamic component 110 and button 70 separate during distribution and occur when generating click sound for the drug of each unit.
It is being applied by spring member 130 or make spring member 130 by biasing needed for torque be preferably small, that is, In the range of 0.5Nmm to 2Nmm.The torque be at zero dose position it is necessary, because of the spring during the setting of dosage Component 130 is wound, and torque increases to the peak torque of such as 5Nmm.The torque applied by spring member 130 is preferably selected So that it has minimum influence to the setting torque that for example user must be unfolded during the drug of setting doses.
By provide gigback, with it is no provide gigback comparable embodiment compared with, interior main body 20 with it is removable The screw pitch of hickey between dynamic component 110 (screw thread 160,161) can reduce 35%.For this purpose, for given agent It measures position or in order to set given dosage, the axial stroke of movable member 110 also reduces 35%.
Axial section when the axial stroke of movable member 110 reduces as mentioned, between adjacent marker 66 Away from can reduce approximate 4.3mm, this, (may especially for big setting dosage for the easy read states of existing display component Need three digits, that is, greater than the drug of 100 units) for, it is considered to be insufficient.Therefore, disclosure offer mentions above And function relevant to the inner segment 76 of dose 70, wherein during the setting of dosage, inner segment accommodate display member 120 Proximal end.
The reduction of the screw pitch of screw thread 160,161 is promoted by gigback mentioned above, because in the distribution of dosage Period, by user apply axial force any part do not need to be used to during the distribution of dosage drive display member 110, Indicating member 60 and movable member 110.Torque must be applied so that indicating member 60 and the return of movable member 110, that is, revolve Turn.In existing apparatus, not returning plus in the case where mechanism, which by user is more than or overcomes hickey 160,161 A part of the axial force of application generates.In order to overcome the interface, lead angle must be sufficiently greatly to overcome frictional force.This limit System reduces the range of the pitch of hickey, is especially considering that at the hickey, device is to the sensibility of friction.
Therefore, using the given driving assembly including gigback, driving mechanism be significantly not easily susceptible to or independent of Frictional dissipation at hickey.
By reducing the axial stroke of movable member 110, limited finger is set or had especially for large dosage For the user of movement, the ergonomics operation or design of medicine delivery device 100 are also improved.Reduce movable member The 110 axial travel distance (with reference to the D in Fig. 2), such as when setting the drug of maximum dose, also allow for reducing The length of piston rod 30 and interior main body 20, this is so that can be realized shorter single unit system length.
It is enough to make movable member 110 through indicating member by the torque that spring member 130 provides during the distribution of dosage Therefore 60 rotations and/or return make display member 120 return and/or be distally moved.Also it is enough to overcome in movable member The distribution click acoustical generator being arranged between 110 and dose 70.Any remaining torque be applied to movable member 110 with it is interior Hickey between shell 20 generates small axis at this axially coupled portion between movable member 110 and drive member 40 Xiang Li.Therefore, when distributing the drug of doses, spring member 130 can provide drive member 40 small axial auxiliary force.
In order to use the device 100, user must select dosage by being rotated in a first direction dose 70.Due to Being threadedly engaged between movable member 110 and inner housing 20, dose 70 are laid out from device 100, such as in setting operation mould In formula, dose 70 is relative to movable member 110 by spin locking.In addition, the quantity of unit count with being incremented by and It is shown by display member window 123, the display member window 123 is mobile to nearside also relative to shell.Button 70 is along first The rotation in direction promotes driver 40 to rotate, and in doing so, it advances along piston rod 30, and piston rod 30 is entirely being dialled It is kept fixed between refunding.Can be under setting dosage in maximum, stop configurations 69,127 shown in Figure 11 and Figure 12 are against to prevent It is incremented by dosage further.
Final dose component or nut 50 provide the function of calculating the sum of distributed unit.Nut 50 is in end-of-life When locking device 100 cannot select or set bigger drug dose Just because of this.Final dose nut 50 and driver 40 are threadedly engaged relative to each other, as explained above.In addition, the last one dose nut 50 is mounted in spline 22, As shown in figure 8, making nut 50 together with interior main body 20 (always) is by spin locking.Through the rotation of dose during switch Then the rotation of indicating member 60 is caused to bias spring member 130.In addition, the rotation of piston rod promotes nut 50 along drive Dynamic device 40 advances.Nut 50 freely axially slides always in interior main body 20, this allows nut 50 to advance.In Figure 14 and Figure 15 Shown in the variation (refer to 46,47,55,56) of screw thread towards final dose make nut 50 in the axial direction towards end-of-life locking condition Accelerate to advance.Under the conditions of end-of-life, the stop configurations 54 of the last one dose nut 50 contact corresponding on driver 40 Structure 48.It makes a response with the spline contact of interior main body 20 to any torque transmitted by these stop configurations 48.
Under the required dosage of institute's switch, device 100 gets out dosage distribution.This will need distad promoting button 70, this will lead to the disengaging of clutch or locking teeth 74,114.As mentioned above, when switch dosage, button 70 is by ' outward Biasing ', and the locking teeth 74,114 that movable member 110 is rotationally locked to button 70 is engaged.Push button 70 it Afterwards, locking teeth 74,114 is detached from, and the relative rotation between movable member 110 and button 70 be it is possible (with reference to Fig. 3 and Fig. 8).Under all conditions, driver 40 and button 70 by engagement by spin locking together with.Meanwhile button 70 relative to The relative axial movement of driver 40 causes pocket or recess portion 73 to shift relative to protrusion 45.It is therefore prevented that protrusion 45 is inside Flexure is resisted against on the non-recess region of button 70 (with reference to recess portion 73) because protrusion stops 45.Under this condition, then driver 40 It is rotatably constrained to interior main body 20 with button 70, therefore prevents any rotation relative to shell 10.
Utilize selected desired amount, user can manually push button 70 to drive driving mechanism with distribution agent Amount, piston rod 30 are driven forwards to distribute drug from cylindrantherae 80.Therefore, it is passed by the driving force that user applies through driving mechanism Piston rod is handed to drive piston rod 30 along distal direction relative to shell 10.
The interaction of matching screw thread between piston rod 30, driver 40 and movable member 110 and inner housing 20 can To convey the mechanical advantage of 2:1 or 3:1.
When button 70 has been pressed and device is under batch operation mode, the spring member 130 that is biased Energy be used to driving gigback, wherein movable member 110 relative to shell in a second direction towards its initial position backward Rotation.Above-mentioned distribution click acoustical generator mechanism is also driven by spring member 130.Specifically, spring member 130 makes indicating member 60 It is rotated in a second direction towards its initial position relative to shell, wherein indicating member 60 is rotationally locked to through spline 128,131 Movable member.Since display member 120 is threadedly coupled to movable member 110, display member window 123 is also axially returned Or move backward, to indicate the actual dose information during batch operation at once.
Preferably, the spring force of spring member 130 is less than the driving force needed for operating device under batch operation mode, makes The drug for obtaining doses is assigned.
In the design of the medicine delivery device 100 proposed, although being not explicitly described, do not need to load (priming) mechanism of medicine delivery device 100 can also be applied.
Protection scope is not limited to example given above.The present invention is real with the combination of each novel characteristics and each characteristic It applies, even if stating this combination of this feature or feature not yet explicitly in the claims or in this example, the present invention is also special Ground includes every kind of combination of the arbitrary characteristics stated in the claims.
10 shell, 11 lens element
16 17 proximal ends of distal ends
20 inner housings, 22 spline of interior main body (interior main body)
23 internal screw threads (interior main body), 30 piston rod
31 bearing, 40 drive member, driver
44 resilient finger-shaped member, 45 protrusion
46 first screw thread (dose), 47 second screw thread (dose)
48 drive member stop configurations, 50 nut, final dose component
54 final dose stop configurations, 55 proximal thread (final dose component)
56 distal threads (final dose component) 57 recess portions (final dose component)
58 ribs (final dose component) 60 indicating members
64 color segment, 65 flexible arm
The other color segment of 66 labels 67
The 68 maximum stop configurations (indicating member) of minimum stop configurations (indicating member) 69
70 doses, 72 sleeve-like parts of button
73 recess portions (dose), 74 locking teeth (dose)
76 inner segment, 80 cylindrantherae
81 cylindrantherae storage unit, 82 piston, tube plug
83 metal tape, 100 medicine delivery device
110 movable member, 114 locking teeth (movable member)
120 display member, 121 label
122 display member window, 123 shell window
124 display member screw thread, 125 movable member screw thread
126 minimum dose stop configurations, 127 maximum dosage backstop structure
128 movable member spline, 129 protrusion
130 spring member, 131 indicating member spline
160 internal screw threads (movable member), 161 external screw thread (interior main body)
X longitudinal axis D axial distance
1. the driving assembly that one kind is used for medicine delivery device (100), comprising:
Shell (10), shell (10) have proximal end (17) and distal end (16),
Driving mechanism, driving mechanism include piston rod (30) and drive member (40) and the agent for being connected to drive member (40) It measures component (70), drive member (40) distributes the drug of doses to drive piston rod (30), and dose (70) can The mobile drug to set doses,
Gigback, gigback include spring member (130),
Movable member (110), movable member (110) are connected to spring member (130), and wherein driving assembly is configured to So that
Under the setting operation mode of driving assembly, movable member (110) is connected to dose (70), and is passing through During the setting of the dosage of mobile dose (70), movable member (110) is moved to dose setting position from initial position, Thus biased spring member (130), and wherein, when movable member (110) is in dose setting position, dosage Component (70) can be actuated by the user with the batch operation mode by driving assembly from setting pattern switching to driving assembly, and its In,
Under batch operation mode, drive member (40) and movable member (110) separation, so that driving mechanism can be by user Operated by applying driving force to driving mechanism, and wherein, the spring member (130) of gigback independently of driving force and Movable member (110) are driven towards the initial position of movable member (110).
2. driving assembly according to claim 1, wherein spring member (130) is torsion spring, and driving assembly quilt It is configured so that, during the setting of dosage, movable member (110) is rotated in a first direction relative to shell (10), and During the distribution of dosage, movable member (110) is rotated in the second direction opposite to the first direction relative to shell (10).
3. driving assembly according to claim 1 or 2, wherein dose (70) is revolved relative to drive member (40) Twist lock is fixed, and wherein, driving assembly includes releasable clutch mechanism, which is constructed such that, Under setting operation mode, dose (70) is rotatable relative to shell (10), and under batch operation mode, clutch knot Structure (45) interacts with complementary clutch configuration (22), so that dose (70) is relative to shell (10) by rotation lock It is fixed.
4. driving assembly according to claim 1 or 2, wherein movable member (110) is threadedly coupled to shell (10), And wherein, driving assembly is constructed such that, during the setting of dosage, the axial stroke of dose (70) is by removable The screw thread that thread connection is established between dynamic component (110) and shell (10) limits.
5. driving assembly according to claim 1 or 2, is constructed such that, under batch operation mode, applied by user Driving force be transferred to piston rod (30) through driving mechanism, by piston rod (30) relative to shell (10) along distal direction drive It is dynamic.
6. driving assembly according to claim 1 or 2, wherein movable member (110) and dose (70) can be released Rotary locking mechanism connection is put, and wherein, driving assembly is constructed such that, it is releasable to rotate under setting operation mode Locking mechanism is engaged, so that movable member (110) and dose (70) be by spin locking, and wherein, when setting When under operation mode, movable member (110) is in dose setting position, and user is distally moved dose (70), Releasable rotary locking mechanism is detached from, so that movable member (110) and dose (70) rotate freely relative to each other, and And driving assembly is switched to batch operation mode.
7. driving assembly according to claim 1 or 2, wherein driving assembly is constructed such that, works as movable member (110) in dose setting position when, the energy being stored in spring member (130) is used to driving gigback and drive Dynamic feedback mechanism, when administered, feedback mechanism can be operated to provide visual, audible and/or tactile feedback.
8. driving assembly according to claim 1 or 2, wherein driving assembly includes display member (120), wherein showing Component (120) relative to shell (10) by spin locking, and wherein, when movable member (110) is moved to from initial position When dose setting position, the mobile axial distance of display member (120) is greater than dose (70) mobile axial distance.
9. driving assembly according to claim 8, wherein driving assembly includes indicating member (60), wherein display member It (120) include display member window (122), and indicating member (60) includes label (66), and wherein, driving assembly is by structure Cause so that, during the operation of driving assembly, display member (120) is axially moved relative to indicating member (60) so that Different labels (66) is visible by display member window (122).
10. driving assembly according to claim 8, wherein dose (70) includes inner segment (76), and is wherein driven Component is constructed such that, when movable member (110) is in dose setting position, the proximal segment of display member (120) It is retained in inner segment (76), and wherein, when movable member (110) is in initial position, proximal segment is disposed in The outside of inner segment (76).
11. driving assembly according to claim 1 or 2, wherein the induction element of driving assembly includes the first thread segment (46) and the second thread segment (47), which has the first lead, which, which has, is greater than the Second lead of one lead, and wherein, driving assembly includes final dose component (50), when dosage increases, the last agent Amount component (50) can be operated to be moved to end position from starting position, and wherein, final dose component (50) is configured to When final dose component is arranged in starting position or is interacted when close to starting position with the first thread segment (46), and its In, final dose component (50) is configured to be arranged in end position when final dose component (50) or when close to end position It interacts with the second thread segment (47).
12. driving assembly according to claim 11, wherein final dose component (50) is configured to and the first thread segment (46) it being threadedly engaged with the second thread segment (47), and wherein, drive member (40) includes drive member stop configurations (48), and And final dose component (50) includes final dose stop configurations (54), which is configured to when end When secondary dose (50) and the second thread segment (48) interact, rotation is formed together with drive member stop configurations (48) and is stopped Block piece, so that preventing setting dosage from further increasing.
13. driving assembly according to claim 11, wherein the first thread segment and the second thread segment are one start screw, and And second thread segment overall diameter be greater than the first thread segment overall diameter.
14. driving assembly according to claim 1 or 2, wherein spring member (130) is connected to drive member (40) simultaneously And it is constructed such that, drive needed for being less than operation driving mechanism in the spring force of batch operation mode lower elastic member (130) Power.
15. a kind of includes the medicine delivery device (100) according to the driving assembly of at least one in precedent claims.
CN201480019964.9A 2013-04-10 2014-04-08 Driving assembly for medicine delivery device CN105102028B (en)
EP13163102 2013-04-10
EP13163102.0 2013-04-10
PCT/EP2014/056996 WO2014166914A1 (en) 2013-04-10 2014-04-08 Drive assembly for a drug delivery device
CN105102028A CN105102028A (en) 2015-11-25
CN105102028B true CN105102028B (en) 2019-02-01
ID=48083023
CN201480019964.9A CN105102028B (en) 2013-04-10 2014-04-08 Driving assembly for medicine delivery device
US (1) US10232118B2 (en)
EP (1) EP2983761B1 (en)
JP (1) JP6417393B2 (en)
CN (1) CN105102028B (en)
DK (1) DK2983761T3 (en)
HK (1) HK1214778A1 (en)
WO (1) WO2014166914A1 (en)
CN101616705A (en) * 2006-11-17 2009-12-30 塞诺菲-安万特德国有限公司 Dosing and drive mechanism for drug delivery device
2014-04-08 CN CN201480019964.9A patent/CN105102028B/en active IP Right Grant
2014-04-08 US US14/782,657 patent/US10232118B2/en active Active
2014-04-08 EP EP14716293.7A patent/EP2983761B1/en active Active
2014-04-08 WO PCT/EP2014/056996 patent/WO2014166914A1/en active Application Filing
2014-04-08 DK DK14716293.7T patent/DK2983761T3/en active
2014-04-08 JP JP2016506898A patent/JP6417393B2/en active Active
2016-03-10 HK HK16102765.1A patent/HK1214778A1/en unknown
JP6417393B2 (en) 2018-11-07
US10232118B2 (en) 2019-03-19
JP2016518189A (en) 2016-06-23
CN105102028A (en) 2015-11-25
US20160045664A1 (en) 2016-02-18
EP2983761A1 (en) 2016-02-17
EP2983761B1 (en) 2017-11-15
WO2014166914A1 (en) 2014-10-16
HK1214778A1 (en) 2016-08-05
DK2983761T3 (en) 2018-02-19
JP2014520613A (en) 2014-08-25 Drug delivery device
US20160235922A1 (en) 2016-08-18 Drug delivery device
AU2010330032B2 (en) 2014-07-24 Drive assembly for a drug delivery device and drug delivery device
CN105102040B (en) 2019-03-08 Dispensing rate control mechanism and injection device
CN106573114A (en) 2017-04-19 Clicker arrangement and drug delivery device herewith
CN105492040B (en) 2019-06-07 Band triggers the needle insertion of the driving mechanism of load on spring manually and retracts sub-assembly
JP6282268B2 (en) 2018-02-21 Drive mechanism and drug delivery devices for drug delivery
KR20140015497A (en) 2014-02-06 Dose setting mechanism and injection device
US20150126940A1 (en) 2015-05-07 Drug delivery device