Source: http://www.google.com/patents/US20110160742?ie=ISO-8859-1&dq=7,446,777
Timestamp: 2015-09-04 02:09:57
Document Index: 338441612

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 60', 'Application No. 61', 'Application No. 61', 'Application No. 61']

Patent US20110160742 - Method for providing progressive therapy for thrombus management - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inAdvanced Patent SearchPatentsSystems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot...http://www.google.com/patents/US20110160742?utm_source=gb-gplus-sharePatent US20110160742 - Method for providing progressive therapy for thrombus managementAdvanced Patent SearchPublication numberUS20110160742 A1Publication typeApplicationApplication numberUS 12/981,336Publication dateJun 30, 2011Priority dateOct 17, 2007Also published asEP2367482A1, EP2367482A4, US8066757, US8070791, US8197493, US8574262, US20110160757, US20110160760, US20110160761, US20110160763, US20110238106, US20120016406, US20120022576, US20120041460, US20120041475, US20120316600, US20140121758, WO2011082319A1Publication number12981336, 981336, US 2011/0160742 A1, US 2011/160742 A1, US 20110160742 A1, US 20110160742A1, US 2011160742 A1, US 2011160742A1, US-A1-20110160742, US-A1-2011160742, US2011/0160742A1, US2011/160742A1, US20110160742 A1, US20110160742A1, US2011160742 A1, US2011160742A1InventorsDavid Ferrera, Andrew H. Cragg, John Fulkerson, Joshua BenjaminOriginal AssigneeMindframe, Inc.Export CitationBiBTeX, EndNote, RefManPatent Citations (5), Referenced by (4), Classifications (23), Legal Events (3) External Links: USPTO, USPTO Assignment, EspacenetMethod for providing progressive therapy for thrombus management
US 20110160742 A1Abstract
1. A method for providing progressive therapy for thrombus management in blood vessels, the method comprising:
identifying a thrombus within a blood vessel; inserting an expandable reperfusion device within the blood vessel to the location of the thrombus, wherein the expandable reperfusion device comprises an expandable reperfusion scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, thereby increasing a diameter of a flow path established by the reperfusion scaffold; deploying the reperfusion device within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus, wherein the one or more blood flow channels facilitate natural lysis of the thrombus; removing the reperfusion device; inserting an expandable thrombus removal device within the blood vessel to the location of the thrombus, wherein the expandable thrombus removal device comprises an expandable removal scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold; deploying the thrombus removal device within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus; extracting the remaining portion of the thrombus engaged by the thrombus removal device from the blood vessel; and removing the thrombus removal device. 2. The method of claim 1, wherein the expandable reperfusion device and the expandable thrombus removal device comprise self-expanding devices.
3. The method of claim 2, wherein the expandable reperfusion device and the expandable thrombus removal device are inserted into the blood vessel within a microcatheter to the location of the thrombus.
4. The method of claim 3, wherein deploying the reperfusion device comprises retracting the microcatheter, thereby allowing the reperfusion device to expand within the thrombus.
5. The method of claim 3, wherein deploying the thrombus removal device comprises retracting the microcatheter, thereby allowing the thrombus removal device to expand within the thrombus.
6. The method of claim 3, wherein removing the reperfusion device comprises resheathing the reperfusion device by advancing the microcatheter over the reperfusion device while keeping the reperfusion device stationary and then removing the microcatheter with the reperfusion device together.
7. The method of claim 1, wherein an expansion diameter of the reperfusion device is configured to provide increased cell deformation of the reperfusion scaffold, thereby reducing protrusion of the thrombus within the reperfusion scaffold.
8. The method of claim 1, wherein an expansion diameter of the thrombus removal device is configured to provide reduced cell deformation of the removal scaffold, thereby increasing thrombus penetration within the removal scaffold.
9. The method of claim 4, further comprising resheathing the reperfusion device within the microcatheter by advancing the microcatheter and then unsheathing the reperfusion device by retracting the microcatheter to provide maceration of the thrombus.
10. The method of claim 1, wherein the cells of the reperfusion scaffold in an expanded configuration have a cell length of between 2 mm and 4 mm and a cell height between 1 mm and 3 mm and wherein the cells of the removal scaffold in an expanded configuration have a cell length of between 4 mm and 6 mm and a cell height between 2 mm and 4 mm.
11. A method for providing progressive therapy for thrombus management, the method comprising:
inserting an expandable reperfusion device within an occluded blood vessel having a thrombus; positioning the expandable reperfusion device to span at least a portion of a length of the thrombus; wherein the expandable reperfusion device comprises a self-expanding reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to inhibit protrusion of the thrombus into the reperfusion scaffold, thereby increasing a diameter of a flow path established by the reperfusion scaffold; deploying the reperfusion device within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing blood flow through the occluded blood vessel, wherein the established blood flow facilitates natural lysis of the thrombus; macerating the thrombus; wherein at least one of the natural lysis and the maceration fragment the thrombus until only a portion of the thrombus remains; removing the reperfusion device; inserting a thrombus removal device within the blood vessel to span at least a portion of a length of the remaining thrombus, wherein the thrombus removal device comprises a self-expanding removal scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to allow thrombus protrusion within the cells, thereby facilitating engagement of the remaining thrombus by the removal scaffold; deploying the thrombus removal device within the remaining thrombus to engage the remaining thrombus; and removing the thrombus removal device, thereby extracting the remaining thrombus. 12. The method of claim 11, wherein macerating the thrombus comprises sheathing and unsheathing of the reperfusion scaffold, wherein said sheathing and unsheathing causes the reperfusion scaffold to compress and expand.
13. The method of claim 11, wherein the reperfusion device and the thrombus removal device are inserted into the blood vessel within a microcatheter.
14. The method of claim 13, wherein deploying the reperfusion device comprises retracting the microcatheter, thereby allowing the reperfusion device to expand within the thrombus.
15. The method of claim 13, wherein deploying the thrombus removal device comprises retracting the microcatheter, thereby allowing the thrombus removal device to expand within the thrombus.
16. The method of claim 13, wherein removing the reperfusion device comprises resheathing the reperfusion device by advancing the microcatheter over the reperfusion device while keeping the reperfusion device stationary and then removing the microcatheter with the reperfusion device together.
17. The method of claim 11, wherein an expansion diameter of the reperfusion device is configured to provide increased cell deformation of the reperfusion scaffold, thereby reducing thrombus penetration within the reperfusion scaffold.
18. The method of claim 11, wherein an expansion diameter of the thrombus removal device is configured to provide reduced cell deformation of the removal scaffold, thereby increasing thrombus protrusion within the removal scaffold.
19. The method of claim 11, wherein the cells of the expandable reperfusion device in an expanded configuration have a cell length of between 2 mm and 4 mm and a cell height between 1 mm and 3 mm and wherein the cells of the expandable thrombus removal device in an expanded configuration have a cell length of between 4 mm and 6 mm and a cell height between 2 mm and 4 mm.
20. The method of claim 11, wherein the struts of the thrombus removal device have a pointed or tapered configuration to facilitate engagement of the thrombus.
21. The method of claim 11, wherein the cell size wherein the cell size of the removal scaffold is variable along the length of the removal scaffold, and further wherein the cell size of the cells at the end portions of the removal scaffold are smaller than the cell size of the cells of the middle portion of the removal scaffold.
This application is a continuation of U.S. patent application Ser. No. 12/980,039 filed Dec. 28, 2010, which is a continuation-in part application of Ser. No. 12/651,353 filed Dec. 31, 2009, which is a continuation-in part application of U.S. patent application Ser. No. 12/123,390 filed May 19, 2008, which claims priority to the following provisional applications: U.S. Provisional Application No. 60/980,736, filed Oct. 17, 2007; U.S. Provisional Application No. 60/987,384, filed Nov. 12, 2007; U.S. Provisional Application No. 60/989,422, filed Nov. 20, 2007; U.S. Provisional Application No. 61/015,154, filed Dec. 19, 2007; U.S. Provisional Application No. 61/019,506, filed Jan. 7, 2008; and U.S. Provisional Application No. 61/044,392, filed Apr. 11, 2008.
In accordance with several embodiments of the invention, a method for providing progressive therapy for thrombus management in blood vessels is provided. In some embodiments, the method comprises identifying a thrombus within a blood vessel. In some embodiments, the method comprises inserting an expandable reperfusion devi