Source: http://www.google.com/patents/US7555332?dq=5,815,794
Timestamp: 2017-11-25 10:52:48
Document Index: 112151742

Matched Legal Cases: ['§119', 'Application No. 60', '§ 120', '§ 119', 'Application No. 60', 'Application No. 60', 'Application No. 60', 'art 1', 'Application No. 03821121', 'Application No. 06013492', 'Application No. 03764754', 'Application No. 2002', 'Application No. 03764754', 'art 1']

Patent US7555332 - Fluorescent light tomography - Google Patents
Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented...http://www.google.com/patents/US7555332?utm_source=gb-gplus-sharePatent US7555332 - Fluorescent light tomography
Publication number US7555332 B2
Application number US 11/829,927
Also published as EP2146752A1, EP2146752A4, US7599731, US20070253908, US20080031494, WO2008124640A1
Publication number 11829927, 829927, US 7555332 B2, US 7555332B2, US-B2-7555332, US7555332 B2, US7555332B2
Inventors Bradley W. Rice, Chaincy Kuo, Daniel G. Stearns, Heng Xu
Patent Citations (103), Non-Patent Citations (59), Referenced by (9), Classifications (16), Legal Events (4)
US 7555332 B2
determining a three-dimensional representation of a fluorescent probe distribution internal to the animal using the photon density internal to the animal and the set of volume elements.
This application is a continuation of U.S. application Ser. No. 11/733,358 filed Apr. 10, 2007, which claims priority under 35 U.S.C. §119(e) and is a non-provisional of U.S. Provisional Application No. 60/840,247, filed on Aug. 24, 2006 and titled “Fluorescent Imaging,” by Rice et al.; the Ser. No. 11/733,358 patent application also claims priority under 35 U.S.C. § 120 and is a continuation-in-part of U.S. patent application Ser. No. 10/606,976, filed Jun. 25, 2003 and titled “Method and Apparatus for 3-D Imaging of Internal Light Sources,” which claimed priority under 35 U.S.C. § 119(e) from a) U.S. Provisional Application No. 60/395,357, filed on Jul. 16, 2002 and titled “Method and Apparatus for 3-D Imaging of Internal Light Sources,” by Stearns et al., b) U.S. Provisional Application No. 60/396,458, filed on Jul. 16, 2002 and titled “In Vivo 3D Imaging of Light Emitting Reporters,” by Rice et al. and c) U.S. Provisional Application No. 60/396,313, filed on Jul. 16, 2002 and titled “3D in Vivo Imaging of Light Emitting Reporters,” by Rice et al.; each of the above listed patent applications is incorporated by reference in its entirety for all purposes.
D = c 3 ( μ A + μ S ) ( 5 )
χ 2 = ∑ i [ ρ i - ∑ j G ij s j ρ i ] 2 ( 6 )
∑ j G ij S j
ρ i ≅ ∑ j G ij s j ( 7 )
G ij = G ij em ∑ k G jk ex s k ext ( 9 )
ρ i ≅ ∑ j [ G ij s j fluor + G ij s j autofluor ] ( 10 )
ρ i - ∑ j G ij s j autofluor ≅ ∑ j G ij s j fluor ( 11 )
G ij = 1 2 π D { exp ( - μ eff r ij ) r ij - 1 z b exp ( r ij / z b ) E 1 [ ( μ eff + 1 z b ) r ij ] } ( 12 )
z b = 2 D c 1 + R eff 1 - R eff ( 14 )
Mouse 2 is placed within box 12 for imaging by opening door 18, inserting the mouse in chamber 21, and closing door 18. Suitable imaging systems are available from Xenogen Corporation from Alameda, Calif., and include the IVIS® Spectrum, IVIS® 3D Series, IVIS® 200 Series, IVIS® 100 Series, and IVIS® Lumina. Further description of a suitable imaging box 12 is provided in commonly owned U.S. Pat. No. 7,113,217 entitled “3-D Imaging Apparatus for In-Vivo Representations”, which is incorporated by reference herein in its entirety for all purposes. Although imaging system 10 is shown with a single cabinet design, other embodiments of the present invention include a disparate imaging box 12 and desktop computer that includes processing system 28 and a dedicated display.
2 Arridge, "Photon-Measurement Density Functions. Part 1: Analytical Forms", Applied Optics, vol. 34, No. 31, 1, 1995, pp. 7395-7409.
12 Chinese Office Action dated Apr. 4, 2008 from Chinese Patent Application No. 03821121.1.
13 Contag et al., "Photonic Detection of Bacterial Pathogens in Living Hosts", Molecular Microbiology, vol. 18, No. 4, 1995, pp. 593-603.
14 Contag et al., "Use of Reporter Genes for Optical Measurements of Neoplastic Disease In Vivo", Neoplasia, vol. 2, No. 1-2, Jan.-Apr. 2000, pp. 41-52.
15 Duponchel et al., "Multivariate curve resolution methods in imaging spectroscopy: influence of extraction methods and instrumental perturbations," J. Chem. Inf. Comput. Sci., vol. 43, No. 6, 2003, pp. 2057-2067.
16 EP Search Report dated Oct. 6, 2006 for EP Application No. EP 06 01 3492.
17 Eppstein et al., "Biomedical Optical Tomography Using Dynamic Parameterization and Bayesian Conditioning on Photon Migration Measurements", Applied Optics, vol. 38, No. 10, Apr. 1, 1999, pp. 2138-2150.
18 European Examination Report dated Apr. 8, 2008 from EP Patent Application No. 06013492.1.
19 European Office Action dated Aug. 21, 2008 from EP Patent Application No. 03764754.2.
26 International Search Report dated Jul. 7, 2008 from PCT Application No. PCT/US08/59492.
29 Jaumot et al., "A graphical user-friendly interface fo MCR-ALS: a new tool for multivariate curve resolution in MATLAB," Chemometrics and Intelligent Laboratory Systems 76, 2005, pp. 101-110.
30 Kienle, "Noninvasive Determination of the Optical Properties of Two-Layered Turbid Media", Applied Optics, vol. 37, No. 4, Feb. 1, 1998, pp. 779-791.
32 Maston (editor), "Biological Techniques: Fluorescent and Luminescent Probes for Biological Activity: A Practical Guide to Technology for Quantitative Real-Time Analysis", Second Edition, Academic Press, 1999.
33 Notice of Allowance dated Mar. 19, 2008 from U.S. Appl. No. 10/151,463.
37 Office Action dated Aug. 4, 2008 from U.S. Appl. No, 10/606,976.
38 Office Action dated Aug. 6, 2008 from U.S. Appl. No. 11/733,358.
39 Office Action dated Jun. 9, 2008 from Japanese Patent Application No. 2002-589773.
40 Office Action received in EP Application No. 03764754.2 dated Feb. 7, 2007.
41 Pickering et al., "Double-integrating-sphere system for measuring the optical properties of tissue," Applied Optics, Feb. 1, 1993, vol. 32, No. 4, pp. 399-410.
42 Prahl et al., "Determining the Optical Properties of Turbid Media by Using the Adding-Doubling Method", Applied Optics, vol. 32, No. 4, Feb. 1, 1993, pp. 559-568.
43 Rehemtulla et al., "Rapid and Quantitative Assessment of Cancer Treatment Response Using In Vivo Bioluminescence Imaging", Neoplasia, vol. 2, No. 6, 2000, pp. 491-495.
44 Research & Development (magazine), vol. 42, No. 9, Sep. 2000, Part 1 of 2.
45 Rice et al., "Advances in 2D In Vivo Optical Imaging Instrumentation," Abstract No. 186, Society for Molecular Imaging 2nd Annual Meeting, Aug. 2003.
46 Rice et al., "In Vivo Imaging of Light-Emitting Probes", Journal of Biomedical Optics, vol. 6, No. 4, Oct. 2001, pp. 432-440.
47 Takeda et al., "Fourier-Transform Method of Fringe-Pattern Analysis for Computer-Based Topography and Interferometry", Optical Society of America, vol. 72, No. 1, Jan. 1982, pp. 156-160.
48 Tauler et al., "Multivariate Curve Resolution Applied to Spectral Data from Multiple Runs of an Industrial Process," Analytical Chemistry, vol. 65, No. 15, Aug. 1, 1993, pp. 2040-2047.
49 Toyooka et al., "Automatic Profilometry of 3-D Diffuse Objects by Spatial Phase Detection", Applied Optics, vol. 25, No. 10, May 15, 1986, p. 1630-1633.
50 Tromberg et al., "Properties of Photon Density Waves in Multiple-Scattering Media", Applied Optics, vol. 32, No. 4, Feb. 1, 1993, p. 607-616.
51 Tuchin, "Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis", SPIE Press, 2000.
52 Weissleder et al., "In Vivo Imaging of Tumors with Protease-Activated Near-Infrared Fluorescent Probes", Nature Biotechnology, vol. 17, Apr. 1999, pp. 375-378.
53 Weissleder et al., "Shedding Light onto Live Molecular Targets", Nature Medicine, vol. 9, No. 1, Jan. 2003, p. 123-1218.
54 Wentzell et al., "Multivariate curve resolution of time course microarray data," BMC Bioinformatics 2006, 7:343, submitted Mar. 18, 2006, published Jul. 13, 2006.
55 Windsor et al., "Imaging Pulmonary Inflammation Using Fluorescence Molecular Tomography," Society for Molecular Imaging, Sep. 23, 2005.
56 Written Opinion dated Jul. 7, 2008 from PCT Application No. PCT/US08/59492.
57 Wu et al., "Noninvasive Optical Imaging of Firefly Luciferase Reporter Gene Expression in Skeletal Muscles of Living Mice", Molecular Therapy, vol. 4, No. 4, Oct. 2001, pp. 297-306.
58 Yang et al., "Whole-Body Optical Imaging of Green Fluorescent Protein-Expressing Tumors and Metastases", PNAS, vol. 97, No. 3, Feb. 1, 2000, pp. 1206-1211.
59 Zhang et al., "Rapid In Vivo Functional Analysis of Transgenes in Mice Using Whole Body Imaging of Luciferase Expression", Transgenic Research, vol. 10, 2001, pp. 423-434.
U.S. Classification 600/473, 600/425, 600/407, 382/128, 250/363.01, 600/431, 600/476
Cooperative Classification G01N2021/6439, G01N2021/1787, G01N21/49, A61B5/0073, G01N2021/6421, G01N2021/6419
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:RICE, BRADLEY W.;KUO, CHAINCY;STEARNS, DANIEL G.;AND OTHERS;REEL/FRAME:020017/0517;SIGNING DATES FROM 20070927 TO 20071001