Source: http://www.google.com/patents/US6391939?ie=ISO-8859-1
Timestamp: 2014-07-13 22:18:08
Document Index: 726325464

Matched Legal Cases: ['application No. 94', 'application No. 88', 'application No. 94', 'application No. 96', 'application No. 94', 'application No. 86']

Patent US6391939 - Collagenic material useful in particular for preventing post-operative adhesions - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign in<nobr>Advanced Patent Search</nobr>PatentsThe present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen,...http://www.google.com/patents/US6391939?utm_source=gb-gplus-sharePatent US6391939 - Collagenic material useful in particular for preventing post-operative adhesionsAdvanced Patent SearchPublication numberUS6391939 B2Publication typeGrantApplication numberUS 09/355,842Publication dateMay 21, 2002Filing dateFeb 5, 1998Priority dateFeb 6, 1997Fee statusPaidAlso published asCA2278662A1, CA2278662C, DE69805166D1, DE69805166T2, EP0964709A1, EP0964709B1, US20010008930, WO1998034656A1Publication number09355842, 355842, US 6391939 B2, US 6391939B2, US-B2-6391939, US6391939 B2, US6391939B2InventorsJean-Louis Tayot, Michel Tardy, Philippe GravagnaOriginal AssigneeImedex BiomateriauxExport CitationBiBTeX, EndNote, RefManPatent Citations (10), Non-Patent Citations (5), Referenced by (22), Classifications (24), Legal Events (4) External Links: USPTO, USPTO Assignment, EspacenetCollagenic material useful in particular for preventing post-operative adhesionsUS 6391939 B2Abstract The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.
In 1994, ORLY I. (6) proposed, on behalf of COLETICA, a transparent collagen membrane which consists of a single layer or of two layers, depending on the examples, and is usually combined with an undegradable prosthesis for treating hernias or eventrations. This membrane consists of undenatured native collagen. It has to be stapled or sutured. In order to make the stapling easier, it is necessary for the membrane to be transparent in order to avoid injuring sensitive zones (nerves and blood vessels), as in the case of inguinal hernias. The risks associated with stapling hernial prostheses, in particular, are well known. For this reason, surgeons will be more interested in gluing these prostheses, thereby avoiding any sutures or staples. ORLY I. specifies, surprisingly, that this membrane should not be adhesive since it is not possible to use the membrane developed by KHOURY et al., in the same Company, i.e. COLETICA (cited above), in this indication due to its adhesive properties, which hinder insertion in association with abdominal surgery. The time taken for resorption in the case of this membrane is considerably longer than one month since resorption is not complete at 5 weeks and 3 months are required for the material to have been almost totally eliminated. Despite these very long periods, the Applicant asserts, paradoxically, that the material has the advantage of a �relatively� rapid resorption time.
�Chemically non-reactive towards the collagen� is understood as meaning a hydrophilic compound which is not able to react with the collagen which is present and which in particular does not form any covalent bond with the collagen while it is being crosslinked.
It can be prepared in a �ready-to-use� form by, for example, cutting a film such as described above to the dimensions which are appropriate for the envisaged application and packing it under sterile conditions.
EXAMPLES Example 1 Preparation of an Acid Precipitate of Collagen which has been Modified by Oxidative Cleavage Using Periodic Acid and which is Not Crosslinked
Example 2 Preparation of Anti-post-operative Adhesion Collagenous Films According to the Invention
Example 3 Preparation of a Collagenous Film in Accordance with Another Embodiment of the Invention
REFERENCES 1. DI ZEREGA G. S. (1994)��Contemporary adhesion prevention� Fertility and Sterility 61(2), 219-235.
2. HARRIS E. S.�MORGAN R. F.�RODEHEAVER G. T. (1995)��Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents�, Surgery, 117(6), 663-669.
3. BECKER J. M.�DAYTON M. T.�FAZIO V. W.�BECK D. E.�STRYKER S. J.�WEXNER S. D.�WOLFF B. G.�ROBERTS P. L.�SMITH L. E.�SWEENEY S. A.�MOORE M. (1996)��Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: A prospective, randomized, double-blind multicenter study�, The J. of Amer. College of Surgeons, 183(4), 297-306.
4. KHOURY W.�ABDUL-MALAK N.�HUC A. (1994)��Membrane collag�nique anti-adh�rence post-op�ratoire (Collagenous anti-post-operative adhesion membrane)�, patent application No. 94 06995 of Jun. 8, 1994 in France (published under No. 2 720 945).
5. TAYOT J. L.�MARESCAUX J.�DUMAS H.�TARDY M. (1988)��Visceral surgery patch�, U.S. Pat. No. 5,201,745, issued on Apr. 13, 1993 (under the priority of French patent application No. 88 03321 of Mar. 15, 1988, issued on Jul. 13, 1990 under No. 2 628 634).
6. ORLY I. (1994)��Use of collagen membranes as peritoneal renewing prostheses�, international patent application WO 96/08277 (under the priority of French patent application No. 94 11 015 of Sep. 9, 1994).
7. YEUNG J. E.�CHU G. H.�DE LUSTRO F. A.�RHEE W. M. (1995)��Anti adhesion films and compositions for medical use�, European patent application No. 96 102 339.7 (published under No. 0 732 110) (under the priority of American patent application serial No. 403 360 of Mar. 14, 1995).
8. TARDY M.�TIOLLIER J.�TAYOT J. L. (1994)��Composition adh�sive, � usage chirurgical, � base de collag�ne modifi� par coupure oxydative et non r�ticul� (Adhesive composition for surgical use, based on collagen which is modified by oxidative cleavage and which is not crosslinked)� �French patent application No. 94 00715 of Jan. 24, 1994, issued on Aug. 2, 1996 under No. 2 715 309.
9. TARDY M.�TAYOT J. L. (1986)��Process for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said process�, patent U.S. Pat. No. 4,931,546 issued on May 6, 1990 (under the priority of French patent application No. 86 10 160 of Jul. 11, 1986, issued on May 12, 1989 under No. 2 601 371).
10. WISEMAN D. �Polymers for the prevention of surgical adhesions� in Polymeric Site-specific pharmaco-therapy, Ed. A. J. DOMB, John Wiley & Sons Ltd, 1994.
11. WISEMAN D. et al., �Fibrinolytic drugs prevent pericardial adhesions in the rabbit� J. of Surgical Research 53, 362-368, 1992.
Patent CitationsCited PatentFiling datePublication dateApplicantTitleUS4931546 *Jul 13, 1987Jun 5, 1990ImedexProcess for the treatment of collagen, notably for facilitating its cross-linking, and the collagen obtained by the application of the said processUS5114627 *Dec 6, 1990May 19, 1992Cbs LensMethod for producing a collagen hydrogelUS5201745Aug 15, 1991Apr 13, 1993ImedexMultilayer; two layers of collagen and adhesiveUS5580923Mar 14, 1995Dec 3, 1996Collagen CorporationSubstrate, e.g collagen, covalently linked to receptive tissue via a bifunctional binding agent; surgeryUS5618551Jan 20, 1995Apr 8, 1997ImedexOxidated collagen or gelatin is non-crosslinkable in acidity, but crosslinkabe in neutral or alkalinityUS5931165Feb 6, 1997Aug 3, 1999Fusion Medical Technologies, Inc.Films having improved characteristics and methods for their preparation and useEP0732110A1Feb 16, 1996Sep 18, 1996Collagen CorporationAnti-adhesion films and compositions for medical useFR2715309A1 Title not availableFR2720945A1 Title not availableWO1996008277A1Sep 14, 1995Mar 21, 1996ColeticaUse of collagen membranes as peritoneal renewing prostheses* Cited by examinerNon-Patent CitationsReference1Becker et al., Prevention of Postoperative Abdominal Adhesions By A Sodium Hyaluronate-Based Bioresorbable Membrane: A Prospective, Radomized, Double-Blind Multicenter Study, Journal of the American College of Surgeons, vol. 183, pp. 287-306 (Oct., 1996).2diZerega M.D., Gere S., Contemporary Adhesion Prevention, Fertility and Sterility, vol. 61, No. 2, pp. 219-235 (Feb., 1994).3Harris et al., Analysis of the Kinetics of Peritoneal Adhesion Formation in the Rat and Evaluation of Potential Antiadhesive Agents, Surgery, vol. 117, No. 6, pp. 663-669 (Jun., 1995).4Wiseman et al., Fibrinolytic Drugs Prevent Pericardial Adhesions in the Rabbit, Journal of Surgical Research, vol. 53, pp. 362-368 (1992).5Wiseman, David, Polymers for the Prevention of Surgical Adhesions, Polymeric Site-specific Pharmacotherapy, pp. 370-421 (1994).Referenced byCiting PatentFiling datePublication dateApplicantTitleUS6596304 *Sep 16, 1999Jul 22, 2003Imedex BiomateriauxMethod for preparing two-layer bicomposite collagen material for preventing post-operative adhesionsUS6706684 *Nov 9, 1999Mar 16, 2004Imedex BiomateriauxNon-toxic, sterile, biocompatible, crosslinked collagen by subjecting to beta or gamma radiationUS7670762Jan 17, 2006Mar 2, 2010Brennen Medical, LlcMaking an absorbable remodelable graft material that is hair-free and immunologically inert; e.g. pig skin treatment for tissue engineering materialUS7758654May 20, 2004Jul 20, 2010Kensey Nash CorporationAnti-adhesion deviceUS8198087Jul 30, 2007Jun 12, 2012Sofradim Production SasTissue engineering supportUS8282959Nov 27, 2007Oct 9, 2012Actamax Surgical Materials, LlcBranched end reactants and polymeric hydrogel tissue adhesives therefromUS8361164Jul 19, 2010Jan 29, 2013Kensey Nash CorporationAnti-adhesion deviceUS8414907Apr 28, 2005Apr 9, 2013Warsaw Orthopedic, Inc.Coatings on medical implants to guide soft tissue healingUS8426492Nov 14, 2008Apr 23, 2013Actamax Surgical Materials, LlcOxidized cationic polysaccharide-based polymer tissue adhesive for medical useUS8431114Oct 6, 2005Apr 30, 2013Actamax Surgical Materials, LlcPolysaccharide-based polymer tissue adhesive for medical useUS8466327Aug 31, 2009Jun 18, 2013Actamax Surgical Materials, LlcAldehyde-functionalized polyethers and method of making sameUS8551136Jul 6, 2009Oct 8, 2013Actamax Surgical Materials, LlcHigh swell, long-lived hydrogel sealantUS8580950Dec 21, 2010Nov 12, 2013Actamax Surgical Materials, LlcAldehyde-functionalized polysaccharidesUS8580951Jul 1, 2010Nov 12, 2013Actamax Surgical Materials, LlcAldehyde-functionalized polysaccharidesUS8715636Mar 8, 2013May 6, 2014Actamax Surgical Materials, LlcPolysaccharide-based polymer tissue adhesive for medical useUSRE39172 *Sep 16, 1999Jul 11, 2006Imedex BiomateriauxMethod for preparing two-layer bicomposite collagen material for preventing post-operative adhesionsEP2522376A2Oct 16, 2009Nov 14, 2012Sofradim ProductionMethod for preparing auto-sealant matrix for tissue repairWO2009016518A2 *Jul 30, 2008Feb 5, 2009Sofradim ProductionBiological mesh tissue engineering supportWO2009016519A2 *Jul 30, 2008Feb 5, 2009Sofradim ProductionBioresorbable implantWO2009022230A2 *Jun 27, 2008Feb 19, 2009Sofradim ProductionDural repair materialWO2009022231A2 *Jun 27, 2008Feb 19, 2009Sofradim ProductionReinforced composite implantWO2012123582A1Mar 16, 2012Sep 20, 2012Sofradim ProductionProsthesis comprising a three-dimensional and openworked knit* Cited by examinerClassifications U.S. Classification523/105, 524/35, 522/88, 523/106, 524/54, 524/21, 524/58, 524/28, 522/87, 524/56, 524/27, 523/111, 524/18, 527/101, 524/17, 524/47, 527/200International ClassificationA61L31/00, A61L31/14, A61L31/04Cooperative ClassificationA61L31/148, A61L31/041European ClassificationA61L31/04B, A61L31/14KLegal EventsDateCodeEventDescriptionNov 21, 2013FPAYFee paymentYear of fee payment: 12Oct 17, 2009FPAYFee paymentYear of fee payment: 8Oct 16, 2005FPAYFee paymentYear of fee payment: 4Aug 5, 1999ASAssignmentOwner name: IMEDEX BIOMATERIAUX, FRANCEFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TAYOT, JEAN-LOUIS;TARDY, MICHEL;GRAVAGNA, PHILIPPE;REEL/FRAME:010176/0001Effective date: 19990426RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services©2012 Google