Source: https://patents.google.com/patent/KR101436150B1/en
Timestamp: 2020-03-28 22:41:21
Document Index: 115972335

Matched Legal Cases: ['art 32', 'art 21', 'art 13', 'art 13', 'art 13', 'art 30', 'art 21', 'art 30', 'art 21', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 30', 'art 21', 'art 30', 'art 21', 'arts 30', 'art 21']

KR101436150B1 - Biosensor and measuring apparatus therefor - Google Patents
Biosensor and measuring apparatus therefor Download PDF
KR101436150B1
KR101436150B1 KR1020110096046A KR20110096046A KR101436150B1 KR 101436150 B1 KR101436150 B1 KR 101436150B1 KR 1020110096046 A KR1020110096046 A KR 1020110096046A KR 20110096046 A KR20110096046 A KR 20110096046A KR 101436150 B1 KR101436150 B1 KR 101436150B1
KR1020110096046A
KR20130032461A (en
최재규
주식회사 세라젬메디시스
2011-09-23 Application filed by 주식회사 세라젬메디시스 filed Critical 주식회사 세라젬메디시스
2011-09-23 Priority to KR1020110096046A priority Critical patent/KR101436150B1/en
2013-04-02 Publication of KR20130032461A publication Critical patent/KR20130032461A/en
2014-09-01 Publication of KR101436150B1 publication Critical patent/KR101436150B1/en
The present invention discloses a biosensor measuring device capable of always obtaining reliable measurement results by allowing only biosensors and measuring devices to match with each other.
The present invention relates to a measuring device in which a receiving part for inserting a biosensor is formed, wherein a dedicated coupling part corresponding to each of the contact surfaces of the biosensor and the receiving part of the measuring device in contact with each other is formed, So that the biosensor can be inserted into the accommodating portion only.
TECHNICAL FIELD [0001] The present invention relates to a biosensor,
The present invention relates to a biosensor and a measuring device thereof, and more particularly, to a biosensor and a biosensor which can be used only when the biosensor and the measuring device are matched with each other, To a measuring device.
A biosensor is a means for examining the properties of a substance using the functions of a living organism. The biosensor is excellent in sensitivity and response specificity because it uses a biosubstance such as blood sugar or ketone as a detection element. Therefore, it is used in a wide range of fields such as clinical chemical analysis in the medical / pharmaceutical field, process measurement of the bio industry, environmental measurement, and evaluation of the stability of chemical substances, and its range is continuously expanding. In particular, biosensors are widely used for various self tests such as blood glucose measurement, pregnancy diagnosis, and urinalysis and for diagnosing rapid diseases.
Biosensors are classified into enzymatic analysis and immunoassay according to the analysis method, and the substances to be analyzed in the biological sample are classified into an optical biosensor and an electrochemical biosensor according to a quantitative analysis method.
Enzyme assays Biosensors utilize specific reactions between enzymes and substrates, enzymes and enzyme inhibitors. Immunoassays Biosensors utilize specific reactions of antigens and antibodies. An optical biosensor is the most commonly used method of measuring the concentration of a target substance by measuring light transmittance, absorbance or wavelength change. The reaction mechanisms of various substances to be analyzed are already known, and since they are measured after a sufficient reaction time, there is an advantage in that there is little variation in measurement time. However, it has a disadvantage in that the measurement time is long and a large amount of sample is required compared with an electrochemical biosensor. In addition, there is a disadvantage in that the measurement result is influenced by the turbidity of the sample and it is difficult to miniaturize the optical part.
An electrochemical biosensor is a method for measuring the concentration of a target substance by measuring an electric signal obtained from a reaction. The electrochemical biosensor is capable of signal amplification with a very small amount of sample, is easy to miniaturize, can stably obtain measurement signals, and can be easily fused with information communication devices.
Electrochemical biosensors are typically used for blood glucose measurement. Electrochemical biosensors are used to measure electrical signals generated by an electrochemical reaction that occurs when a sample such as blood is introduced into a biosensor and are transmitted to a measuring device connected to or connected to the biosensor to be.
Such biosensors generally cause different results in the same biomaterial since their characteristics are different for each production lot. In order to solve such a problem, a measuring device connected to a biosensor performs correction suitable for each production lot of the biosensor, and leads to the same result.
Most of the conventional biosensors have a thin stick shape. In particular, since the portions to be inserted into the slits of the measuring device are mostly constructed in a similar structure, biosensors having different characteristics are inserted into the same measuring device, Is generated.
As described above, the calibration algorithm applied to the measurement device is not compatible with the inserted biosensor, so that the measurement device may exhibit erroneous measurement results, thereby causing an accident in the medical field.
SUMMARY OF THE INVENTION It is an object of the present invention to provide a biosensor and a measurement device thereof that can prevent insertion of a biosensor only when the biosensor and the measurement device are matched with each other, have.
A biosensor according to any one of claims 1 to 3, wherein the biosensor is a biosensor. The biosensor according to claim 1, wherein the biosensor So that the sensor can be inserted into the accommodating portion.
More preferably, the dedicated fastening portion includes at least one protrusion protruding from the inner surface of the receiving portion, which is the contact surface, toward the biosensor; And at least one coupling groove formed on an outer circumferential surface of the biosensor as the contact surface and extending along a longitudinal direction inserted and inserted into a shape corresponding to the projection so that the projection can be inserted.
More preferably, the dedicated fastening portion is formed on at least one protrusion protruding from the outer circumferential surface of the biosensor as the contact surface, and on the inner surface of the accommodating portion as the contact surface, and the protrusion is inserted into the protrusion And at least one coupling groove extending along the longitudinal direction to be inserted and inserted into the corresponding shape.
More preferably, the projections have a polygonal cross-sectional shape.
More preferably, the projections have a streamlined cross-sectional shape.
More preferably, the biosensor further comprises: a base substrate; A reaction substrate coupled to the base substrate and generating a reaction signal according to a reaction with the target biomaterial, and transferring the reaction signal to an electrically connected measurement device; A working electrode and a reference electrode formed on the reaction substrate; And a capillary flow path formed between the base substrate and the reaction substrate, the capillary flow path having a sample introduction part opened at one side and an air discharge part at an intermediate part.
More preferably, the measuring apparatus further comprises: an input unit through which a user inputs information; A storage unit for storing data; A display unit for displaying data; And a control unit for controlling the device by input from the user, the data input / output of the storage unit, and the display of the display unit according to the preset status.
More preferably, the biosensor accommodated in the measuring device having the accommodating portion includes: a reaction substrate for generating a reaction signal according to a reaction with the introduced sample and transmitting the generated reaction signal to the electrically connected measuring device; And a base substrate coupled to the reaction substrate to form a capillary flow path including a reaction chamber, wherein a dedicated fastening portion is provided at one side of the base substrate received in the accommodation portion, And the biosensor is accommodated in the accommodating portion only when the dedicated fastening portion is shaped in the accommodating portion.
More preferably, the exclusive engagement portion is formed of at least one projection and at least one engagement groove.
More preferably, a region of the entire area of the biosensor accommodated in the measuring device has a cross-section in a direction of insertion into the measuring device is the same as an inside shape of the accommodating portion.
As described above, the biosensor and the measuring apparatus according to the present invention can be combined only when the measuring apparatus and the biosensor are matched with each other by the dedicated fastening unit. When another type of biosensor is inserted into the measuring apparatus It is possible to prevent a measurement error that may occur, thereby improving the reliability of the product.
1 is a perspective view showing a biosensor and a measuring device thereof according to a first preferred embodiment of the present invention,
Fig. 2 is a schematic view of the measuring apparatus shown in Fig. 1,
FIG. 3 is a perspective view of the biosensor shown in FIG. 1,
FIG. 4 is a sectional view showing a state in which a biosensor is coupled to the measurement device shown in FIG. 1;
5 is a cross-sectional view illustrating a state in which a biosensor is coupled to a measuring device according to a second preferred embodiment of the present invention.
FIG. 6 is a sectional view showing a state in which a biosensor is coupled to a measuring device according to a third preferred embodiment of the present invention. FIG.
FIG. 7 is a detailed view of a measuring apparatus according to a fourth preferred embodiment of the present invention and a method of coupling the measuring apparatus to the measuring apparatus.
Hereinafter, a biosensor and a measuring device thereof according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.
FIG. 1 is a perspective view illustrating a biosensor and a measuring device thereof according to a first preferred embodiment of the present invention, FIG. 2 is a schematic view of the measuring device shown in FIG. 1, FIG. 4 is a cross-sectional view illustrating a state in which a biosensor is coupled to the measurement apparatus shown in FIG. 1. FIG.
1 to 4, in one preferred embodiment of the present invention, the biosensor and the measuring apparatus thereof may include a dedicated coupling part 32 of a specific shape. The measuring device 20 may include a receiving part 21 in which the biosensor 10 is received. The receiving portion 21 may include a dedicated coupling portion 31 that is shaped to match the dedicated coupling portion 32.
The biosensor 10 includes a base substrate 11 as a body and a reaction substrate 20 which is coupled to the base substrate 11 and generates a reaction signal according to a reaction between the introduced sample and the measurement signal, (12).
The capillary flow path 13 is formed between the reaction substrate 12 and the base substrate 11 while the reaction substrate 12 is assembled. The capillary flow path 13 may include a sample introduction part 13a through which an opening is formed at one side of the capillary flow path 13 to inject the sample. When the sample is introduced into the sample introduction part 13a, the sample is moved through the capillary flow path 13 by the capillary phenomenon. An air discharge unit (not shown) may be formed in a part of the capillary flow passage 13 to penetrate the outside. The air discharging part discharges air at the time of inhaling the sample to facilitate the inhalation of the rapid sample, and is preferably formed at an area opposite to the sample introduction part 13a or at regular intervals.
The capillary flow passage 13 is formed in a gap between the two while the reaction substrate 12 is assembled to the base substrate 11. In this space, an area where the reaction electrode is formed on the reaction substrate 12 forms a reaction chamber. The reaction electrode is composed of the working electrode 19 and the reference electrode 14, and the reagent 16 is applied thereon Can be immobilized. An electrochemical reaction occurs between the sample and the reagent 16 in the reaction chamber, and thus a reaction signal is generated. The working electrode 19 and the reference electrode 14 transmit the reaction signal to the measuring device 20 through the signal transmitting portion 17 electrically connected to each other. The signal transmitting portion 17 may be formed on the same surface or on the other surface as the working electrode 19 and the reference electrode 14. If the signal transmitting portion 17 is formed on the other surface, 19 and the reference electrode 14 through the light oil holes. The reaction substrate 12 is preferably implemented by a printed circuit board (PCB) or a flexible PCB (FPCB), and the working electrode 19, the reference electrode 14, and the signal transfer unit 17 are plated thereon Shape is preferable.
The measuring device 20 is formed with a receiving portion 21 in which the biosensor 10 is received. The measurement apparatus 20 includes an input unit 22 for inputting information by a user, a storage unit 23 for storing data, a display unit 24 for displaying data, And a control unit 25 for controlling the data input / output of the display unit 23 and the display of the display unit 24 in accordance with the preset status.
A special coupling part 30 having a shape corresponding to each other is formed on the contact surfaces of the biosensor 10 and the measuring device 20 which contact the receiving part 21, So that the biosensor 10 can be received (or inserted) only in the receiving portion 21. That is, only when the end face of the biosensor 10 in the inserting direction coincides with the inside shape of the accommodating portion 21 of the measuring device 20 in the area accommodated in the measuring device 20 in the entire area of the biosensor 10, (10) can be received in the receiving portion (21) of the measuring device (20).
The dedicated fastening part 30 is provided on the inner surface 21a of the accommodating part 21 which is one of the contact surfaces of the biosensor 10 and the receptacle 21 of the measuring device 20, And at least one protrusion 31 protruding toward the outer surface 10 of the biosensor 10 and a protrusion 31 formed on the outer circumferential surface 10a of the biosensor 10 as another contacting surface, And an engaging groove 32 extending from the engaging recess 32.
The protrusion 31 has a polygonal cross-sectional shape and the engaging groove 32 is recessed to have a corresponding cross-section. It is preferable that the polygonal cross-sectional shape has a rectangular cross-sectional shape as shown in the figure. However, the present invention is not limited to a rectangular cross-sectional shape, and may be a polygonal cross-sectional shape such as a triangle, pentagon, or hexagon. The biosensor 10 is inserted into the receiving portion 21 of the measuring device 20 only when the shape, position, and number of the dedicated fastening portions 30 are matched with each other. Also, as shown in the drawings, the exclusive fastening part 30 of the present invention has been described as being formed on the upper part of the contact surface. However, the exclusive fastening part 30 includes a structure formed on either side or the lower part. The base substrate 11 is preferably formed of a synthetic resin material such as plastic, which is easy to mold in the side of forming the special fastening portions 30 having various shapes. Likewise, at least a part of the accommodating portion 21 including the dedicated engaging portion 30 is preferably made of a synthetic resin material. In this case, the dedicated fastening portion 30 can be integrally formed in the accommodating portion 21. [
As described above, according to the first preferred embodiment of the present invention, only when the biosensor 10 has the dedicated fastening part 30 matching the measuring device 20 with the measuring device 20, So that the measuring device 20 can be operated. The biosensor 10 can be prevented from being accommodated in the measuring device 20 when the shape and the number and position of the engaging groove 32 and the protrusion 31 constituting the dedicated engaging portion 30 are not coincident with each other, Thereby preventing the generation of time errors. The reagent on the working electrode 19 and the reference electrode 14 react with the sample to generate a reaction signal when the sample is charged after the biosensor 10 is accommodated in the accommodating portion 21 of the matching measuring device 20 And the response signal is transmitted to the control unit 25 through the signal transmitting unit 17 and the receiving unit 21 of the measuring device 20 (the connecting means provided in the receiving unit 21). The control unit 25 applies a correction algorithm to the measurement result according to the reaction signal and displays the resultant value on the display unit 24 as a numerical value.
In this way, only the biosensor 10 and the measuring device 20, which are constructed in a structure having different types of dedicated fastening portions 30 for different types of the biosensor 10 and the measuring device 20, It is possible to prevent measurement errors by providing a reliable connection between the biosensor and the measuring device.
Similarly, in the biosensor and the measuring apparatus according to the second preferred embodiment of the present invention, as shown in FIG. 5, the protrusions 31 constituting the dedicated fastening part 30 are formed in a structure having a streamlined cross-sectional shape , And the engaging groove 32 is structured so as to extend along the direction in which it is recessed and inserted in a streamline shape corresponding to the shape of the protrusion 31 which protrudes in a streamlined manner.
The biosensor 10 can be accommodated (or inserted) into the accommodating portion 21 of the measuring device 20 only when the shape, position, and number of the dedicated fastening portions 30 match each other can do. The exclusive fastening part 30 of the present invention has been described by taking the shape formed on the upper part of the contact surface as an example, but it also includes a structure formed on either side or the lower part.
The structure and operation of the exclusive engagement portion 30 are the same as those of the first preferred embodiment of the present invention except for the structure in which the shape of the exclusive engagement portion 30 is streamlined.
In the biosensor and the measuring apparatus according to the third preferred embodiment of the present invention, as shown in FIG. 6, the contact surfaces of the biosensor 10 and the receptacle 21 of the measuring apparatus 20, The biosensor 10 can be accommodated (or inserted) into the accommodating portion 21 only when the dedicated engaging portions 30 are engaged and matched with each other.
The dedicated fastening part 30 has at least one protrusion 30 protruding from the outer circumferential surface 10a of the biosensor 10 which is one of the contact surfaces of the biosensor 10 and the receptacle 21 of the measuring device 20, And is formed on the inner surface 21a of the accommodating portion 21 which is another contact surface and is formed into a shape corresponding to the protrusion 31 so that the protrusion 31 can be inserted, And an engagement groove 32 extending in the longitudinal direction. When the dedicated fastening part 30 protrudes from the outer circumferential surface 10a of the biosensor 10 as described above, the measuring device 20 is configured such that the protruding projections 31 of the biosensor 10 are engaged with the coupling It is possible to start the operation after recognizing that the biosensor 10 is inserted into the groove 32. To this end, recognition means for recognizing the protrusion 31 may be provided in at least a part of the region of the coupling groove 32.
The protrusion 31 has a polygonal cross-sectional shape and the engaging groove 32 is recessed to have a corresponding cross-section. In the present invention, the polygonal cross-sectional shape is not limited to the triangular cross-sectional shape but may be a polygonal cross-sectional shape such as a rectangle, a pentagon, or a hexagon. The biosensor 10 is accommodated in the accommodating portion 21 of the measuring device 20 only when the shape, position, and number of the dedicated fastening portions 30 are matched with each other. Also, as shown in the drawings, the exclusive fastening part 30 of the present invention has been described as being formed on the upper part of the contact surface. However, the exclusive fastening part 30 includes a structure formed on either side or the lower part.
Structures and operations other than the structure in which the protrusions 31 are formed on the outer circumferential surface 10a of the biosensor 10 and the engaging grooves 32 are formed on the inner side surface 21a of the accommodating portion 21, 1 embodiment.
Although not shown, the shapes of the respective fastening portions 30 described in the first, second, and third preferred embodiments of the present invention can be mixed with each other. In other words, the protrusion 31 may be formed in a structure in which the exclusive engagement portion 30 having a rectangular cross-sectional shape is mixed with the exclusive engagement portion 30 having a different polygonal cross-sectional shape or a streamlined shape, And the structure in which the protrusions 31 are formed on the outer peripheral surface 10a of the biosensor 10 (third embodiment) may be formed in a mixed shape.
7, the protrusion 31 of the dedicated fastening part 30 may have at least one protrusion 31 which interrupts a certain area of the receiving part 21, as shown in FIG. 7. In the biosensor and the measuring device according to the fourth embodiment of the present invention, It can be formed into a columnar shape or an equivalent level shape. Accordingly, the matching groove 32 of the matched biosensor 10 matched with the measuring device 20 is formed into a shape that is recessed by a predetermined depth in the end region of the biosensor 12 in accordance with the shape and position of the projection 31 As shown in FIG.
It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the appended claims and their equivalents. Of course, such modifications are within the scope of the claims.
10: Biosensor 10a: outer peripheral surface
20: Measuring device 21:
21a: Inner side surface 30: Dedicated fastening portion
31: projection 32: engaging groove
In a measuring apparatus (20) having a receiving part (21) into which a biosensor (10) is inserted,
A dedicated coupling part 30 is formed at a portion where the biosensor 10 and the receiving part 21 of the measurement device 20 are coupled to each other and the dedicated coupling parts 30 are engaged with each other Only the biosensor 10 can be inserted into the accommodating portion 21,
The biosensor (10)
A base substrate 11;
A reaction substrate (12) coupled to the base substrate (11) and generating a reaction signal according to a reaction with the target biomaterial and transferring the reaction signal to a measurement device (20) electrically connected thereto;
A working electrode 19 and a reference electrode 14 formed on the reaction substrate; And
And a capillary channel (13) formed between the base substrate (11) and the reaction substrate (12) and having a sample inlet (13a) open at one end and an air outlet at an intermediate end Measuring device of the sensor.
[3] The apparatus according to claim 1, wherein the exclusive engagement portion (30)
At least one protrusion (31) protruding from the inner surface (21a) of the receiving part (21) toward the biosensor; And
The biosensor according to any one of claims 1 to 3, wherein the biosensor (10) further comprises at least one engaging groove (32) formed in an outer circumferential surface (10a) of the biosensor (10) (32). &Lt; / RTI &gt;
At least one protrusion (31) protruding from the outer circumferential surface (10a) of the biosensor (10): and
At least one coupling part formed on the inner side surface 21a of the receiving part 21 and extending along the longitudinal direction to be inserted and inserted in a shape corresponding to the projection 31 so that the projection 31 can be inserted, And a groove (32).
The measuring device for a biosensor according to claim 2 or 3, wherein the projection (31) has a polygonal cross-sectional shape.
The measuring device for a biosensor according to claim 2 or 3, wherein the projection (31) has a streamlined cross-sectional shape.
4. Apparatus according to any one of the preceding claims, characterized in that the measuring device (20)
An input unit 22 for the user to input information;
A storage unit (23) for storing data;
A display section (24) for displaying data; And
And a control unit (25) for controlling the apparatus by input from the user, the data input / output of the storage unit, and the display of the display unit according to the predetermined state.
In a biosensor (10) accommodated in a measuring device (20) having a receiving part (21)
A reaction substrate (12) for generating a reaction signal according to a reaction with the introduced sample and transferring the reaction signal to the electrically connected measuring device (20); And
A base substrate 11 coupled with the reaction substrate 12 to form a capillary flow path 13 including a reaction chamber; / RTI &gt;
A special engagement portion 30 is provided at one side of the base board accommodated in the accommodation portion 21 so as to form a shape with the accommodation portion 21 so that the special engagement portion 30 Wherein the biosensor (10) is accommodated in the accommodating portion (21) only when the biosensor (10) is shaped to engage.
9. The apparatus according to claim 8, wherein the dedicated fastening portion (30)
, At least one protrusion (31), and at least one coupling groove (32).
9. The biosensor according to claim 8, wherein a region of the entire area of the biosensor (10) accommodated in the measuring device (20) has a cross section in a direction of insertion into the measuring device (20) And the biosensor is the same as the biosensor.
KR1020110096046A 2011-09-23 2011-09-23 Biosensor and measuring apparatus therefor KR101436150B1 (en)
KR1020110096046A KR101436150B1 (en) 2011-09-23 2011-09-23 Biosensor and measuring apparatus therefor
US14/346,761 US20140334979A1 (en) 2011-09-23 2012-08-23 Biosensor and Measurement Apparatus for Same
PCT/KR2012/006725 WO2013042877A2 (en) 2011-09-23 2012-08-23 Biosensor and measurement apparatus for same
CN201280046526.2A CN103827669A (en) 2011-09-23 2012-08-23 Biosensor and measurement apparatus for same
JP2014531706A JP2014526705A (en) 2011-09-23 2012-08-23 Biosensor and measuring device thereof
BR112014006859A BR112014006859A2 (en) 2011-09-23 2012-08-23 biosensor and its measuring device
EP12833567.6A EP2759834A2 (en) 2011-09-23 2012-08-23 Biosensor and measurement apparatus for same
KR20130032461A KR20130032461A (en) 2013-04-02
KR101436150B1 true KR101436150B1 (en) 2014-09-01
ID=47914983
US (1) US20140334979A1 (en)
EP (1) EP2759834A2 (en)
JP (1) JP2014526705A (en)
KR (1) KR101436150B1 (en)
CN (1) CN103827669A (en)
BR (1) BR112014006859A2 (en)
WO (1) WO2013042877A2 (en)
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2011-09-23 KR KR1020110096046A patent/KR101436150B1/en active IP Right Grant
2012-08-23 WO PCT/KR2012/006725 patent/WO2013042877A2/en active Application Filing
2012-08-23 JP JP2014531706A patent/JP2014526705A/en not_active Withdrawn
2012-08-23 BR BR112014006859A patent/BR112014006859A2/en not_active IP Right Cessation
2012-08-23 CN CN201280046526.2A patent/CN103827669A/en not_active Application Discontinuation
2012-08-23 EP EP12833567.6A patent/EP2759834A2/en not_active Withdrawn
2012-08-23 US US14/346,761 patent/US20140334979A1/en not_active Abandoned
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