Source: https://patents.google.com/patent/WO2006076921A1/en
Timestamp: 2019-11-18 23:29:00
Document Index: 630700171

Matched Legal Cases: ['art 31', 'art 31', 'art 33', 'art 36', 'art 38', 'arts 36', 'arts 36', 'arts 36', 'art 36', 'arts 36']

WO2006076921A1 - An automatic injection device with a top release mechanism - Google Patents
An automatic injection device with a top release mechanism Download PDF
WO2006076921A1
WO2006076921A1 PCT/DK2006/000032 DK2006000032W WO2006076921A1 WO 2006076921 A1 WO2006076921 A1 WO 2006076921A1 DK 2006000032 W DK2006000032 W DK 2006000032W WO 2006076921 A1 WO2006076921 A1 WO 2006076921A1
PCT/DK2006/000032
2005-01-21 Priority to DKPA200500113 priority Critical
2005-01-21 Priority to DKPA200500113 priority
2006-01-20 Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
2006-07-27 Publication of WO2006076921A1 publication Critical patent/WO2006076921A1/en
2018-01-19 First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36218443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006076921(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
2019-06-25 Priority claimed from US16/452,049 external-priority patent/US20190314579A1/en
AN AUTOMATIC INJECTION DEVICE WITH A TOP RELEASE MECHANISM
For example, EP 0 516 473 Al discloses an injection device having a needle which, when the device is operated, is first caused to project, then liquid is forced out through it, and finally the needle is automatically retracted. The needle extends forwardly from a capsule that can slide longitudinally within a barrel-like body, a relatively weak spring normally maintaining the capsule and needle retracted. A more powerful spring acts oppositely on a plunger which, when released, shoots the capsule forward by acting on the liquid therein, and then forces the liquid out through the projecting needle. At the end of the forward stroke the plunger and capsule are decoupled and the weak spring returns the exhausted capsule and its needle to the retracted position. The spring acting on the plunger can be released by a release button positioned on the outer surface of the injection device.
In WO 01/41838 discloses a handheld injection device by which set doses of a liquid medicament can be injected from a medical reservoir, such as cylinder ampoule, by release of a power reservoir in the device. The power reservoir can either be an electric battery by which a motor can be energized to press out a set dose of medicine, or a strained spring maintained in its strained position by a detent which spring when released can press out a set dose of medicine. When the power reservoir is released, the liquid medicine will be pressed out from the cylinder ampoule through an injection needle mounted on the cylinder ampoule or on the injection device carrying the cylinder ampoule. The power reservoir is released fully or partially by activating a release button, such as an electric switch, located on the housing of the injection device and in the distal half of the length of the injection device. By making at least a part of the distal third of the injection device of an ergonomic shaped cross section, the user can grip the injection device as a pencil is gripped by a thumb, an index finger and a long finger. In both EP 0 516 473 Al and WO 01/41838 the release buttons are positioned on an outer surface of the injection devices. In EP 0 516 473 Al the release button is position on the outer side of the cylindrical body, whereas in WO 01/41838 the release button is positioned close to the injection needle of the injection device. However, it may be advantageous to position the release button or mechanism so that the injection device can be activated by providing a force to the upper region of the injection device - preferably to a release button or mechanism arranged axially with the injection device.
The drive member may be adapted to rotate the associated piston rod upon releasing the accumulated energy in the power reservoir. However, in its first axial position, the drive member is prevented from rotating because the drive member engages at least part of a housing of the injection device. The injection device may further comprise a resilient member, such as a linear spring, for biasing the drive member in a direction towards the dose setting member. The linear spring operatively connects the drive member and the housing. The dose setting member may be adapted to be moved a distance along an axial direction of the injection device so as to move the drive member between the first and second axial positions. The drive member may be adapted to be moved from the first to the second axial position by applying a force to the dose setting member, the force being applied along the axial direction of the injection device.
The handheld injection device may further comprise a rotatabiy mounted display member adapted to display the dose to be ejected from the injection device in accordance with a setting of the dose setting member, the rotatabiy mounted display member being rotatable over an angle corresponding to at least one revolution of the display member. The display member may comprise a dose indicator barrel having numerals arranged along a substantially helical path on an outer surface thereof. Alternatively or in addition, the display member may comprise a counting device having two or more display wheels having numerals arranged on an outer surface thereof.
Fig. 9 shows one way of implementing the release mechanism for releasing the energized power reservoir, Fig. 10 shows another way of implementing the release mechanism for releasing the energized power reservoir,
The energy released when the release button 3 is mechanical energy. The power reservoir can be a resilient member, such as a torsion spring, the resilient member being, when released, adapted to press out a set dose of medicine from the medical reservoir through the injection needle. The release button is operatively connected to some sort of release mechanism adapted to release the resilient member when the release button is actuated. Fig. 3 shows a cross-sectional view of one embodiment of the present invention. The injection device shown in Fig. 3 comprises a housing 6, a dose setting member 7, a drive member 8, a piston rod 9, a torsion spring 10, a biasing spring 11, a cylindrical ampoule 12 and a release member 13. Fig. 3 shows the injection device in a state where the dose setting member 7 is in its dose setting position.
In Fig, 9 a torsion spring (not shown) is energized by rotating a ratchet 28 which is operatively connected to the housing 30 of the injection device when the dose to be injected is being set. In the dose setting position the ratchet 28 is operatively connected with housing part 31 via ratchet arm 32. Energy accumulated in the torsion spring is released by displacing the ratchet 28 axially whereby it is released from its connection with housing part 31 in that the ratchet arm 32 is moved into housing part 33 whereby the piston rod 34 is allowed to rotate thereby expelling a set dose of medicament.
In the embodiment depicted in Fig. 10 the ratchet 35 is only in indirect operation with the housing 39. The drive member of the embodiment depicted in Fig. 10 is constituted by three part - one part 36 being adapted to corporate with the housing 39, another part 38 being adapted to drive the piston rod 40 and a flexible member 37 connecting parts 36 and 38. The flexible member 37 is flexible in the axial direction but establishes a substantially stiff connection between parts 36 and 38 when these parts are rotated relative to each other. Thus, the flexible member 37 ensures that parts 36 and 38 are not rotatably arranged relative to each other. Thus, when the ratchet 35 is moved towards the needle end of the injection device the part 36 is disconnected from the housing 39 whereby parts 36, 37 and 38 are allowed to rotate thereby rotating the piston rod 40. The rotating piston rod 40 causes a set dose of medicament to be expelled from the injection device. The embodiment depicted in Fig. 11 is similar to the embodiment in Fig. 9 except that the piston rod is moved forward by having guiding tracks arranged in the housing (instead of in the drive member) and a threaded engagement between piston rod and the drive member (instead of a threaded engagement between piston rod and housing).
3. A handheld injection device according to claim 1 or 2, wherein the release member is operatively connected to the dose setting member of the injection device.
6. A handheld injection device according to any of the preceding claims, wherein the release member is axially arranged relative to the injection device, and wherein the release member forms a push button like release member.
7. A handheld injection device according to any of the preceding claims, wherein the power reservoir comprises a resilient member, such as a torsion spring or a linear spring, the resilient member being, when released, adapted to press out a set dose of medicine from the medical reservoir through the injection needle.
8. A handheld injection device according to any of the preceding claims, further comprising a rotatably arranged drive member (8) being adapted to at least partly engage with at least part of a drive track of an associated piston rod (9), the drive member (8) being adapted to be positioned in a first axial position when the dose setting member (7) is in a dose setting position, the drive member (8) further being adapted to be positioned in a second axial position when the dose setting member (7) is in a dose injection position, the drive member (8) being adapted to release energy accumulated in the power reservoir (10) when the drive member (8) is in its second axial position.
10. A handheld injection device according to claim 8 or 9, wherein the drive member is prevented from rotating when it is in its first axial position.
11. A handheld injection device according to any of claims 8-10, further comprising a resilient member, such as a linear spring, for biasing the drive member in a direction towards the dose setting member.
12. A handheld injection device according to any of claims 8-11, wherein the dose setting member is adapted to be moved a distance along an axial direction of the injection device so as to move the drive member between the first and second axial positions, the drive member being movable from the first to the second axial position by applying a force to the dose setting member, the force being applied along the axial direction of the injection device.
13. A handheld injection device according to any of claims 8-12, further comprising a rotatably mounted display member adapted to display the dose to be ejected from the injection device in accordance with a setting of the dose setting member, the rotatably mounted display member being rotatable over an angle corresponding to at least one revolution of the display member, the display member comprising a dose indicator barrel having numerals arranged along a substantially helical path on an outer surface thereof.
14. A handheld injection device according to any of claims 8-13, further comprising the associated the piston rod, the piston rod having a threaded outer surface with the drive track arranged in a longitudinal direction of the outer surface of the piston rod.
15. A handheld injection device according to any of claims 8-14, wherein the drive member is operatively connected to the dose setting member via a ratchet.
PCT/DK2006/000032 2005-01-21 2006-01-20 An automatic injection device with a top release mechanism WO2006076921A1 (en)
EP06701034.8A EP1843809B1 (en) 2005-01-21 2006-01-20 An automatic injection device with a top release mechanism
US11/813,435 US8096978B2 (en) 2005-01-21 2006-01-20 Automatic injection device with a top release mechanism
JP2007551546A JP4970282B2 (en) 2005-01-21 2006-01-20 Automatic injection device with release mechanism on top
ES06701034.8T ES2633917T3 (en) 2005-01-21 2006-01-20 Automatic injection device with a superior release mechanism
DK06701034.8T DK1843809T3 (en) 2005-01-21 2006-01-20 Automatic injection device with a top transmission mechanism
CA 2594764 CA2594764C (en) 2005-01-21 2006-01-20 An automatic injection device with a top release mechanism
AU2006207744A AU2006207744B2 (en) 2005-01-21 2006-01-20 An automatic injection device with a top release mechanism
BRPI0606607-0A BRPI0606607A2 (en) 2005-01-21 2006-01-20 Portable injection device
US13/326,738 US9108002B2 (en) 2005-01-21 2011-12-15 Automatic injection device with a top release mechanism
US14/797,350 US9616180B2 (en) 2005-01-21 2015-07-13 Automatic injection device with a top release mechanism
US15/441,638 US10376652B2 (en) 2005-01-21 2017-02-24 Automatic injection device with a top release mechanism
US16/452,049 US20190314579A1 (en) 2005-01-21 2019-06-25 Automatic injection device with a top release mechanism
US11/813,435 A-371-Of-International US8096978B2 (en) 2005-01-21 2006-01-20 Automatic injection device with a top release mechanism
US81343508A A-371-Of-International 2008-06-02 2008-06-02
US13/326,738 Continuation US9108002B2 (en) 2005-01-21 2011-12-15 Automatic injection device with a top release mechanism
WO2006076921A1 true WO2006076921A1 (en) 2006-07-27
AU (1) AU2006207744B2 (en)
BR (1) BRPI0606607A2 (en)
PL (1) PL1843809T3 (en)
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2006-01-20 US US11/813,435 patent/US8096978B2/en active Active
2006-01-20 EP EP06701034.8A patent/EP1843809B1/en active Active
2006-01-20 DK DK06701034.8T patent/DK1843809T3/en active
2006-01-20 PL PL06701034T patent/PL1843809T3/en unknown
2006-01-20 RU RU2007127537A patent/RU2401133C2/en active
2006-01-20 WO PCT/DK2006/000032 patent/WO2006076921A1/en active Application Filing
2006-01-20 BR BRPI0606607-0A patent/BRPI0606607A2/en not_active Application Discontinuation
2006-01-20 CN CN 200680002764 patent/CN100571805C/en active IP Right Grant
2006-01-20 JP JP2007551546A patent/JP4970282B2/en active Active
2006-01-20 AU AU2006207744A patent/AU2006207744B2/en active Active
2006-01-20 CA CA 2594764 patent/CA2594764C/en not_active Expired - Fee Related
2006-01-20 ES ES06701034.8T patent/ES2633917T3/en active Active
2011-12-15 US US13/326,738 patent/US9108002B2/en active Active
2015-07-13 US US14/797,350 patent/US9616180B2/en active Active
2017-02-24 US US15/441,638 patent/US10376652B2/en active Active
JP2010504779A (en) * 2006-09-29 2010-02-18 ノボ・ノルデイスク・エー／エス Injection device having electronic detection means
US10328210B2 (en) 2013-02-01 2019-06-25 Novo Nordisk A/S Non-axial working end-of content mechanism and an injection device comprising the same
CN106573114A (en) * 2014-07-01 2017-04-19 赛诺菲 Clicker arrangement and drug delivery device herewith
US10220154B2 (en) 2014-07-01 2019-03-05 Sanofi Drug delivery device
US10226582B2 (en) 2014-07-01 2019-03-12 Sanofi Drug delivery device
DK1843809T3 (en) 2017-07-31
BRPI0606607A2 (en) 2010-03-16
JP4970282B2 (en) 2012-07-04
CA2594764C (en) 2014-01-14
CN101107031A (en) 2008-01-16
CN100571805C (en) 2009-12-23
RU2007127537A (en) 2009-02-27
JP2008528071A (en) 2008-07-31
US8096978B2 (en) 2012-01-17
US20120083746A1 (en) 2012-04-05
US10376652B2 (en) 2019-08-13
AU2006207744A1 (en) 2006-07-27
CA2594764A1 (en) 2006-07-27
US9108002B2 (en) 2015-08-18
EP1843809A1 (en) 2007-10-17
US9616180B2 (en) 2017-04-11
US20150314076A1 (en) 2015-11-05
ES2633917T3 (en) 2017-09-26
US20080306446A1 (en) 2008-12-11
AU2006207744B2 (en) 2011-08-11
EP1843809B1 (en) 2017-04-19
RU2401133C2 (en) 2010-10-10
US20170165431A1 (en) 2017-06-15
PL1843809T3 (en) 2017-09-29
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