Source: http://www.google.com/patents/US5447529?dq=U.S.+patent+number+7,325,728&ei=Y93TTteOAe702wW6uqi1BQ
Timestamp: 2016-08-30 04:20:25
Document Index: 286479450

Matched Legal Cases: ['art.\n3', 'art.\n4', 'art.\n6', 'art.\n7', 'art.\n9', 'art.\n10']

Patent US5447529 - Method of using endocardial impedance for determining electrode-tissue ... - Google PatentsSearch Images Maps Play YouTube News Gmail Drive More »Sign inPatentsA method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber...http://www.google.com/patents/US5447529?utm_source=gb-gplus-sharePatent US5447529 - Method of using endocardial impedance for determining electrode-tissue contact, appropriate sites for arrhythmia ablation and tissue heating during ablationAdvanced Patent SearchPublication numberUS5447529 APublication typeGrantApplication numberUS 08/188,514Publication dateSep 5, 1995Filing dateJan 28, 1994Priority dateJan 28, 1994Fee statusLapsedAlso published asCA2179058A1, US5562721, US5673704, WO1995020361A1Publication number08188514, 188514, US 5447529 A, US 5447529A, US-A-5447529, US5447529 A, US5447529AInventorsFrancis E. Marchlinski, David S. Schwartzman, Mark S. Mirotznik, Kenneth R. Foster, Charles D. Gottleb, Isaac ChangOriginal AssigneePhiladelphia Heart Institute, The Trustees Of The University Of Pennsylvania, Catholic University Of AmericaExport CitationBiBTeX, EndNote, RefManPatent Citations (13), Non-Patent Citations (2), Referenced by (179), Classifications (24), Legal Events (8) External Links: USPTO, USPTO Assignment, EspacenetMethod of using endocardial impedance for determining electrode-tissue contact, appropriate sites for arrhythmia ablation and tissue heating during ablation
US 5447529 AAbstract
1. A method of locating a source of arrhythmia in a beating heart, comprising:inserting an impedance measuring electrode of a catheter into a chamber of a beating heart; measuring impedance of endocardium at various locations within the chamber of the beating heart using said electrode of said catheter; and determining a border zone between normal and infarcted endocardium based upon measured impedance, said border zone being said source. 2. A method in accordance with claim 1, wherein inserting step includes inserting said measuring electrode of said catheter into a left ventricle of the beating heart.
3. A method in accordance with claim 1, wherein inserting step includes inserting said measuring electrode of said catheter into a right ventricle of the beating heart.
4. A method of locating a source of arrythmia and reducing the risk of future arrythmia in a beating heart, comprising:inserting an electrode of a catheter into a chamber of a beating heart, said electrode being adapted for impedance measuring and ablation; measuring impedance of endocardium at various locations within the chamber of the beating heart using said electrode of said catheter; determining a border zone between normal and infarcted endocardium based upon measured impedance; and using said electrode of said catheter to ablate endocardium in said border zone. 5. A method in accordance with claim 4, wherein inserting step includes inserting said electrode of said catheter into a left ventricle of a beating heart.
6. A method in accordance with claim 4, wherein inserting step includes inserting said electrode of said catheter into a right ventricle of the beating heart.
7. A method of locating a source of arrythmia and infarcted myocardial tissue in a beating heart, comprising:inserting an impedance measuring electrode of a catheter into a chamber of a beating heart; measuring impedance of endocardium at various locations within the chamber of the beating heart using said electrode of said catheter; and comparing the measured impedance values with predetermined ranges of values to identify an infarcted area and an infarct border area of myocardium and distinguishing such areas from normal myocardium. 8. A method in accordance with claim 7, wherein inserting step includes inserting said measuring electrode of said catheter into a left ventricle of the beating heart.
9. A method in accordance with claim 7, wherein inserting step includes inserting said impedance measuring electrode of said catheter into a right ventricle of the beating heart.
10. A method in accordance with claim 1 wherein said step of determining a border zone between normal and infarcted endocardium includes the step of determining three predetermined ranges of impedance values, a highest range of impedance values being normal endocardium, a lowest range of impedance values representing infarcted endocardium and a middle range of impedance values representing said border zone and the source of arrythmia.
11. A method in accordance with claim 4 wherein said step of determining a border zone between normal and infarcted endocardium includes the step of determining three predetermined ranges of impedance values, a highest range of impedance values being normal endocardium, a lowest range of impedance values representing infarcted endocardium and a middle range of impedance values representing said border zone.
12. A method in accordance with claim 7, including the step of establishing predetermined ranges of values to identify an infarcted area and an infarct border area of myocardium.
13. A method in accordance with claim 12 wherein said step of establishing predetermined ranges of values includes the step of measuring the impedance of normal endocardium of a patient being treated and deriving from the normal endocardium impedance values ranges of impedance values for infarcted areas and infarct border areas.
14. A method in accordance with claim 12 wherein said step of establishing predetermined ranges of values to identify the infarcted area and the infarct border area include the step of performing impedance measurements of the endocardium in a plurality of beating hearts and recording ranges of the impedance values for future use.
15. A method of locating infarcted myocardial tissue in a beating heart, comprising:inserting an impedance measuring electrode of a catheter into a chamber of a beating heart; measuring impedance of endocardium at various locations within the chamber of the beating heart using said electrode of said catheter; and comparing measured impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguishing such area from normal myocardium. 16. A method of locating a border zone separating normal and infarcted myocardium, comprising:inserting an impedance measuring electrode of a catheter into a chamber of a beating heart; measuring impedance of endocardium at various locations within the chamber of the beating heart using said electrode of said catheter; and comparing measured impedance values with a predetermined range of values to identify a border zone separating normal and infarcted myocardium and to distinguish such area from normal and infarcted myocardium. Description
The terms impedance or electrical impedance as utilized herein are intended in their broadest sense, that is including the resistive component and/or inductive reactance and/or capacitive reactance, including the condition wherein the capacitive and inductive reactances may cancel or are nonexistent leaving only the resistive component as the impedance. In a co-pending application filed the same day as this application, application Ser. No. 08/138,142, filed by some of the same applicants herein and entitled Systems and Methods for Examining the Electrical Characteristics of Cardiac Tissue, the term "E-Characteristic" has been utilized in connection with such impedance and resistance values.
For the purpose of illustrating the invention, there shown in the drawings forms which are presently preferred; it being understood, however, that this invention is not limited to the precise arrangements and instrumentalities shown.
One suitable electrode for a catheter tip is illustrated in FIG. 1 wherein the tip is provided with a disc shape 10 which is provided with a predetermined significant depth which enhances heat dissipation. In the one example illustrated in FIG. 1, the disc shaped catheter may preferably have dimensions of a diameter 12 of 2.33 mm and a depth of 0.25 mm. However, it is understood that other dimensions of catheter tips may be utilized in practicing the method of the present invention. The catheter shaft 14 is preferably fitted with a recording electrode 16 which acts as a second electrode four recording purposes, such as recording local electrograms. The catheter utilized herein may be provided with one or more other electrodes so that various electrograms may be measured. Electrograms may also be measured with the impedance measurement electrode. Adequate recording of electrograms does not require sole contact of an electrode with the endocardial area of interest.
It is further noted that the methods described and illustrated herein are not limited to use in the myocardium. The impedance measuring method to determine differences in tissue, the method of determining whether the electrode is in contact with the tissue and the method of assessing adequate ablation of undesired tissue may be used in various applications in the body, including, but not limited to ablation of tumors, cancerous or benign, or the like.
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ClassificationA61B18/14, A61N1/05, A61N1/40Cooperative ClassificationA61B2018/00702, A61B2090/065, A61B18/1402, A61N1/025, A61B18/1492, A61N1/40, A61B2018/126, A61N1/05, A61B2018/00875, A61B2034/2051, A61N1/056European ClassificationA61N1/02A, A61B18/14V, A61N1/05N, A61N1/05, A61N1/40Legal EventsDateCodeEventDescriptionDec 5, 1994ASAssignmentOwner name: TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE, PFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FOSTER, KENNETH R.;CHANG, ISAAC;REEL/FRAME:007230/0386Effective date: 19940708Owner name: CATHOLIC UNIVERSITY OF AMERICA, DISTRICT OF COLUMBFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MIROTZNIK, MARK S.;REEL/FRAME:007229/0673Effective date: 19941123Owner name: PHILADELPHIA HEART INSTITUTE, THE, PENNSYLVANIAFree format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MARCHLINSKI, FRANCIS E.;SCHWARTZMAN, DAVID S.;GOTTLIEB, CHARLES D.;REEL/FRAME:007229/0669Effective date: 19940916Mar 19, 1996CCCertificate of correctionMay 28, 1996CCCertificate of correctionJan 5, 1999FPAYFee paymentYear of fee payment: 4Oct 22, 2002FPAYFee paymentYear of fee payment: 8Mar 21, 2007REMIMaintenance fee reminder mailedSep 5, 2007LAPSLapse for failure to pay maintenance feesOct 23, 2007FPExpired due to failure to pay maintenance feeEffective date: 20070905RotateOriginal ImageGoogle Home - Sitemap - USPTO Bulk Downloads - Privacy Policy - Terms of Service - About Google Patents - Send FeedbackData provided by IFI CLAIMS Patent Services