Source: http://www.google.com.tw/patents/US7727181
Timestamp: 2013-06-19 19:27:20
Document Index: 325233240

Matched Legal Cases: ['Application No. 60', 'Application No. 60', 'Application No. 2', 'Application No. 2', 'Application No. 200680018051', 'Application No. 200680018073']

�M�Q US7727181 - Fluid delivery device with autocalibration - Google �M�Q�j�M �Ϥ� �a�� Play YouTube �s�D Gmail ���ݵw�� ��h »�i���M�Q�j�M | �������� | �n�J�i���M�Q�j�M�M�QA micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the...http://www.google.com.tw/patents/US7727181?utm_source=gb-gplus-share�M�Q US7727181 - Fluid delivery device with autocalibration���}��US7727181 B2�X���������v�ӽЮѽs��11/105,711�o�G���2010�~6��1���ӽФ��2005�~4��13�� �u���v���2002�~10��9����L���}�M�Q��CA2604358A1, CA2604358C, CA2738777A1, CN101185042A, CN101185042B, EP1875320A2, EP1875320A4, US7753873, US7753874, US7766864, US8343093, US20050235732, US20090177160, US20090179044, US20090182276, US20100312177, US20110224615, WO2006113408A2, WO2006113408A3���}��105711, 11105711, US 7727181 B2, US 7727181B2, US-B2-7727181, US7727181 B2, US7727181B2�o��HBenjamin M. Rush��M�Q�v�HAbbott Diabetes Care Inc.�M�Q�ޥ� (105), �D�M�Q�ޥ� (23), �Q�H�U�M�Q�ޥ� (3), ���� (39) �~���s��: ���M�Q�ӼЧ�, ���M�Q�ӼЧ��M�Q����T��, �ڬw�M�Q��Fluid delivery device with autocalibrationUS 7727181 B2�K�n A micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the device. The control system measures the output of the pump and adjusts the output of the pump to achieve the desired dosage rate and size. This eliminates differences from pump to pump that result from inevitable variations in the manufacturing of such small scale affordable devices.
determining the time to pump the liquid through the known volume of the portion of the disposable component using, at least in part, a plurality of sensors, wherein each of the plurality of sensors have a plurality of electrodes configured to detect an interruption of a flow stream of the liquid through the known volume portion of the disposable component; and
determining the volume of a dose based at least in part on the determined time to pump the known volume.
2. The method of claim 1, wherein the liquid is insulin.
3. The method of claim 1, wherein initiating the flow of the liquid includes modifying the temperature of the shape memory element.
4. The method of claim 1, further comprising creating a ratio of the determined dose volume to an expected dose volume.
5. The method of claim 4, further comprising modifying a frequency of dosage delivery based upon the ratio.
6. The method of claim 1, including modifying a delivery profile based at least in part on the determined dose volume.
7. The method of claim 6, wherein modifying the delivery profile includes modifying the timing of a subsequent determined dose volume.
8. The method of claim 1, further comprising determining a flow characteristic of the liquid substantially simultaneously with the determining the time to pump the liquid through the known volume of the portion of the disposable component.
9. The method of claim 8, wherein the flow characteristic of liquid corresponds to a voltage of a reaction rate associated with a component of the fluid.
calculating a ratio based upon the comparing the one or more of the measured doses to the expected value of the one or more doses; and
applying the calculated ratio to a subsequent dose when delivering the subsequent dose.
11. The method of claim 10, wherein the plurality of doses includes plurality of insulin doses.
12. The method of claim 10, further comprising modifying a frequency of dosage delivery based upon the comparison.
13. The method of claim 10, including modifying the pumping of the plurality of doses based at least in part on the compared one or more of the measured doses to the expected value of the one or more doses.
14. The method of claim 10, including providing one or more feedback control signals to the control unit based, at least in part, on the measured plurality of doses.
15. The method of claim 14, wherein the one or more feedback control signals includes one or more of measured volume of the one or more of the plurality of doses, or measured time duration of the one or more of the plurality of doses.
16. The method of claim 10, wherein measuring the plurality of doses comprises determining a flow rate of the plurality of doses and substantially simultaneously determining a flow characteristic of the plurality of doses.
17. The method of claim 16, wherein the characteristic of the plurality of doses corresponds to a voltage of a reaction rate associated with a component of a liquid of each of the plurality of doses.
pumping a liquid using, at least in part, a shape memory element, wherein the shape memory element is operatively coupled to a pumping element;
determining a flow characteristic of the liquid substantially simultaneously with the measuring of the time elapsed from the arrival of the liquid at the first sensor to the arrival of the liquid at the second sensor;
calculating a volumetric flow rate of the dispensing device; and
adjusting the volumetric flow rate of the dispensing of the device, based at least in part on the measured time and on the determined flow characteristic of the liquid.
19. The method of claim 18, wherein the liquid includes insulin.
20. The method of claim 18, wherein one or more of the first or the second sensors includes an electrode in fluid contact with the liquid.
21. The method of claim 18, wherein the plurality of electrodes of the first sensor and the plurality of electrodes of the second sensor are configured to detect at least one of a presence of a liquid for each of the plurality of doses and produce a signal indicative of a flow rate of the liquid or, detect an interruption in a flow stream of the liquid.
22. The method of claim 18, wherein the flow characteristic of the liquid corresponds to a voltage of a reaction rate associated with a component of the liquid.
23. The method of claim 18, wherein pumping the liquid includes modifying the temperature of the shape memory element.
24. The method of claim 23, wherein modifying the temperature of the shape memory element includes applying an electrical current to the shape memory element. ����
CROSS REFERENCE TO RELATED APPLICATIONS The present application is a continuation-in-part of U.S. application Ser. No. 10/683,659 of Benjamin M. Rush et al., filed on Oct. 9, 2003 now U.S. Pat. No. 6,916,159, which is related to and claims priority based on U.S. Provisional Application No. 60/417,464, entitled ��Disposable Pump for Drug Delivery System��, filed on Oct. 9, 2002, and U.S. Provisional Application No. 60/424,613, entitled ��Disposable Pump and Actuation Circuit for Drug Delivery System,�� filed on Nov. 6, 2002, each of which is hereby incorporated by this reference in its entirety. The parent application, U.S. application Ser. No. 10/683,659, was published as U.S. Patent Application Publication No. 2004/0115067 A1 and issued as U.S. Pat. No. 6,916,159 on Jul. 12, 2005. The present application is related to U.S. application Ser. No. 11/106,155 of Benjamin M. Rush et al., filed Apr. 13, 2005 entitled ��Variable Volume, Shape Memory Actuated Insulin Dispensing Pump,�� and U.S. application Ser. No. 11/106,256 of Benjamin M. Rush, filed Apr. 13, 2005 entitled ��Methods for Use in Assessing a Flow Condition of a Fluid,�� each of which is filed concurrently with the present application and is hereby incorporated herein, in its entirety, by this reference.
One type of miniature or micro pump utilizes a piston to push a volume of liquid defined by the volume (bore��stroke) of the piston and the volume of an accompanying diaphragm. A dose of the liquid, for example insulin, is said for purposes of discussion, to equal the volume of liquid expelled in one delivery stroke of the piston.
One characteristic of a miniature pump is that the piston diaphragm assembly requires extremely high manufacturing tolerances in order to generate a reproducible dose volume from one pump to the next. For example, with a typically sized miniature piston type pump the volume of the dose will vary by 0.5% per 1/10000 inch of variation in the stroke length. The stroke length is determined by the linear dimensions of three separate components, the piston, the cylinder, and the diaphragm, each of which has tolerances over 1/10000 inch. A coincidence of maximum variation in each of these components would result in a dose volume variation of ��15% from the nominal value. Additional tolerances associated with the diaphragm diameter and the piston head diameter further compound the problem.
The present invention provides a simple, inexpensive and reliable mechanism and method for minimizing, or ��zeroing out�� the differences from pump to pump. One aspect involves a logic or processor controlled routine that may be thought of as an automatic calibration of the device. In a most general sense, this involves measuring the volume of a dosage produced by a given pump, comparing that dosage to a nominal dosage volume expected for that particular type of pump design, and then adjusting the pump output accordingly. This can also be accomplished by measuring the flow rate and then adjusting accordingly. Both volume and flow rate measurement comprise usage of one or more sensors that indicate the presence of liquid at a given point or points. Although there are many ways of adjusting the output of the pump, the preferred way of doing this is by calculating a ratio of a measured versus expected volume and calibrating the delivery based upon the ratio.
In step 130, control unit 150 measures the time it takes for the liquid to travel from point A to point B. The volumetric flow rate is also calculated in step 135 based upon the time measured and the known volume between the points. This information is then used to adjust the delivery of the pump, as is seen in step 140. This process can take place at any time. It can be used initially to calibrate the pump, or during any time during operation of the device. Even if a discrete break is not inserted into the flow stream, the sensors may also indicate the flow rate of the device. The signal produced by the electrodes will increase as the rate of conduction of the liquid increases. Thus, given that the liquid is uniformly mixed, the signal will increase as the flow rate increases. For a given electrode/liquid combination, a profile of the output versus flow rate can be determined for given concentrations. The controller can then reference this data stored in memory to determine the flow rate. For more information on this, please refer to a co-pending U.S. application Ser. No. 11/106,256 of Benjamin M. Rush, entitled ��Methods for Use in Assessing a Flow Condition of a Fluid,�� which is hereby incorporated by this reference in its entirety.
FIG. 2C illustrates drive circuit 250, an embodiment of a circuit that may be used with pump 200. Drive circuit 250 includes input and feedback to/from logic unit 152, which preferably comprises a microprocessor, as mentioned previously. For more information on this and other aspects of a shape memory actuated pump, please refer to co-pending U.S. application Ser. No. 11/106,155 of Benjamin M. Rush et al., entitled ��Variable Volume, Shape Memory Actuated Insulin Dispensing Pump,�� which is hereby incorporated by this reference in its entirety.
1.588 mm (0.0625″)
76.20 mm (3.00″)
2.251 mm3 Measured dose volume
188.47 mg/83 doses = 2.271 mg/dose
(gravimetric)
Dose period
Time to traverse electrodes
Doses to traverse electrodes
184.64 mg/83 doses = 2.225 mg/dose
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