Source: https://patents.google.com/patent/WO1998010704A1/en
Timestamp: 2019-03-22 17:11:35
Document Index: 716706704

Matched Legal Cases: ['art 76', 'art 78', 'art 76', 'art 76', 'art 76', 'art 78', 'art 57', 'art 76', 'art 76', 'art 76']

WO1998010704A1 - Multicomponent tissue adhesive application device and holder for such device - Google Patents
WO1998010704A1
WO1998010704A1 PCT/EP1997/004919 EP9704919W WO9810704A1 WO 1998010704 A1 WO1998010704 A1 WO 1998010704A1 EP 9704919 W EP9704919 W EP 9704919W WO 9810704 A1 WO9810704 A1 WO 9810704A1
PCT/EP1997/004919
1996-09-10 Priority to DE19636622.4 priority Critical
1996-09-10 Priority to DE1996136622 priority patent/DE19636622C1/en
1997-09-09 Application filed by Omrix Biopharmaceuticals S.A. filed Critical Omrix Biopharmaceuticals S.A.
1998-03-19 Publication of WO1998010704A1 publication Critical patent/WO1998010704A1/en
A multicomponent tissue adhesive device (10) provided with several reservoirs (14) respectively for a liquid component, each reservoir (14) presenting a front end (16,20) with an opening (18) enabling the liquid concerned to be dispensed. The front ends (16,20) of the reservoirs (14) are located in accommodating connecting pieces (42) of a connecting head piece (38).The connecting pieces (42) are provided with radially outward extending projecting parts (92). The reservoirs (14) are held by means of a holding device (52). The application device (10) is also provided with a coupling element (74) for releaseably connecting the holding device to the connecting head piece (38), wherein the coupling element (74) presents an encompassing part (76) with several encompassing areas (82) for at least partial encompassing of the accomodating connecting pieces (42) and mounting on the sides opposite the holding device (52) of the projecting parts (92) of the accomodating connecting pieces (42).
On ragvorrichtung for applying a multi-component -
Tissue adhesive and holder for such a
The invention relates to an applicator device for applying a multiple component tissue adhesive. Further, the invention relates to a holder for holding the supply containers and a connecting headpiece to which the storage containers are coupled.
A device for applying a two-component fabric is adhesive-5,104,375 and EP-B 0037393 in each case known from US-A-4, 874, 368, US-A 4,978,336, US-A. In these known Auftragvorriehtungen both the adhesive components-containing storage containers are held together by a holding device, by means of which the application device between the fingers of a hand holding and can be operated with one hand. The tapered outlet of the two supply containers are inserted into the stretched out as spraying formed with cylinder and piston receiving socket of a connecting headpiece. Since these receiving connection piece having an inner cone with the same angle as the external cone of the storage container outlet fitting, there is a wedging of the nozzle of the supply containers with those of the connecting headpiece, thus resulting in so far to a certain axial securing of this coupling connection. These axial retention force can be too low when the said connecting head piece to a common output end by withdrawing of the receiving connector channels are clogged. Thus may come off as a result of pressure build-up within the storage containers, the connecting head of the storage containers what to ragvorrichtung unusable upon actuation of the piston. For this reason, in another known and described in WO-A-95/31137 application device of the connection head is connected via a coupling element to the mounting support device mechanically against unintentional detachment from the outlet of the storage containers secured. The coupling element of this known application device is inserted into detent openings of the connecting head piece and the mounting device. This compound is indeed mechanically reliable but is difficult to solve, what eg for quick refilling the storage containers may be desirable. In the commercially available tissue adhesive AuftragsystemDuploject {duplo ject is a registered trademark) manufactured by Immuno is attached to the connecting head piece elastically a connection strip, the connection remote from the head free end has a bore. The free end can be put on a pin of the mounting device. The mechanical connection of the tab with the mounting device requires a certain precision of the operation, which may be a hindrance.
The invention has for its object to provide a coating device and a support for this application device in which the connecting headpiece for securing against unintended detachment of the storage containers of the holding device is detachably connected, said mechanical connection despite secure balance solved simply and easily and manufactured can be.
To achieve this object an upward is provided supporting apparatus of the invention, which is provided rearward with several supply containers for respectively one fluid component, particularly component a Gewebeklebstoffkompo-, wherein each storage container opposite a front end with an opening for outputting the respective fluid component and a this having end and a piston slidably disposed in the storage container piston with a projecting from the rear end of the piston rod having an actuating end for operating the piston, a connecting head with receiving connection piece for the front ends of the supply containers, said transfer apertures through the connecting head piece between its up and an output end simultaneously dispensing of all the fluid components extending channels for the individual fluid components and wherein the receiving connector are provided with radially outwardly extending projections, a Halterungsvorrichtun g for holding the supply containers in the region of their rear ends, wherein the holder device between the fingers of one hand can be positioned, and a coupling member for releasably connecting the mounting device to the connecting head piece, wherein the coupling element is a surrounding part having a plurality of Umgreifzonen for at least partially engaging around the receiving socket, and having to which the holding device opposite sides of the protrusions of the receiving connection piece to the plant.
rfindungsgemäße holder is provided with a holding device for holding stock containers for the individual fluid components, wherein the retaining device between the fingers of one hand can be positioned, and a coupling element for detachably connecting the holder device with a connection head piece, to which the storage containers can be coupled and at the same time outputting all the fluid components is provided, wherein the coupling element is a surrounding part having a plurality of Umgreifzonen for partially engaging around which are provided with outer projections coupling connector of the connecting headpiece and for engaging behind the outer projections of the coupling piece of the connector having.
According to the invention, the applicator on one end connected to the mounting device coupling member is provided with a surrounding part, which engages around the receiving socket of the connecting headpiece, at least partially, in particular on a circumferential angle ranging between about 200 ° and 300 °. Here, the surrounding part engages behind projections disposed on the receiving connector of the connecting headpiece; Thus, the surrounding part is located on the side opposite to the mounting device side of these projections. Thereby preventing the surrounding part, that the connecting head piece separates from the outlet of the supply containers.
The attachment of the Umgreifteils is particularly quite easy to achieve when the receiving connection piece of the enclosing Umgreifzonen Umgreifteils are resilient, so that the surrounding part can attach to the receiving connection piece side. Due to the resilient flexibility of the particular as secured about 200 ° to 300 ° extending to the receiving connection piece C-shaped bracket formed Umgreifzonen the surrounding part in the mounted state against unintentional lateral sliding of the receiving connection piece.
Preferably, the surrounding part via a connection part, which is in particular designed as a preferably round rod, connected to the holder device. The coupling element therefore in this case has two parts, one of which, namely, the surrounding part, köpfstück cooperates with the connection and is provided for the mechanical connection of surrounding part and holding device, the other part, namely the connection part. The connection part is expediently made in one piece with the reach-round part. It has a free end which can be connected against unintentional loosening of the retainer device. For this purpose, the free end is provided with at least one, preferably a plurality of locking projections, which engage behind the edge of an opening in the mounting device. The connecting part can be pushed into the wide opening of the holder device, more or less, whereby the distance of the Umgreifteils of the mounting device according to the particular circumstances is selected. For application devices with different diameters and the axial length of supply containers in general, different holder devices must be used because the syringe body are mounted normally-locking on the support means, these are so matched to the diameter of the syringe body; because of the variability in length and due to the fact that the connecting head pieces are the same for powered with various syringe bodies application devices, one and the same coupling element can be used in all of these applicators.
In an advantageous development of the invention it is provided that the holder device comprises undergripping -Vorsprünge, which protrude from the plane in which the supply containers held by the holding device are arranged, and that the holder device are provided with retainer housings, into which the storage containers crimping and / or can be latched.
In the above embodiment of the invention, the lower gripping extend out -Vorsprünge from the plane defined by the substantially cylindrical storage containers or their longitudinal ends, in other words, extending perpendicular to this plane. Thus, the distance that the projections engaging below the index and middle fingers from one another when holding the applicator and dispensing of adhesive is substantially reduced compared to the known devices, and brackets, which appreciably facilitates the handling for persons with especially small hands.
The mounting device according to this embodiment of the invention only fulfills the function positioned to keep the storage containers relative to each other, the task to be able to hold the entire application device easily with the hand, by the index and middle finger of one hand engage under the projections of the retainer device. The (Untergreif-) projections extend advantageously only in the area between adjacent storage containers or adjacent retainer housings of the mounting device. The introduction of the storage containers is very simple, because they have to be pressed only in the bracket shooting (lateral) and / or engaged. An axial displacement and / or rotation of the storage containers up in a holding end position for locking on the support device is not needed.
It is advantageous if the retaining device is in the form of a retaining clip having the elastically formed receptacles for insertion and removal of the pre rats containers is. Conveniently, these recordings C-shaped configuration, wherein each C-shaped receiver (hereinafter also referred to terminal) over more than 180 ° and extending the associated Vorratsbehält- nis enclose a clamping manner. In these open bracket shooting, the storage containers can be conveniently and repeatedly switched push to then be clamped due to the elasticity of the recordings. The openings of the receptacles may have to opposite sides or to a common side of the retaining device or are directed to another arbitrary angle. The lower gripping projections are arranged between the openings of the holder receptacles without affecting their accessibility.
In the above embodiment, the esterification Hal- device slides slidably mounted on the supply containers. Thus, the movement of the support device to the rear end of the storage containers out from each of which protrudes a piston rod is limited, cooperating stops are provided on the mounting device and the rear ends of the supply containers. This is the case of the supply containers to the mutually repellent flanges of the syringe body with which they are usually equipped. To these flanges, the mounting device is on, whereby a further relative movement is excluded to the ends of the piston rods towards.
The connection head pieces mostly used in application devices of this type in question have, in addition to the channels for the components of the tissue adhesive also a channel for a medical gas (oxygen) on. This gas channel also has a gas terminal and a gas outlet at the delivery end of the connecting headpiece.
a cannula or a catheter is suitably connected to the output end of the connecting headpiece. In a multi-lumen design of this catheter or cannula of this is to ensure that the lumens at the output end of the coupling head are aligned with the channels or components of the gas channel.
Alternatively, a cannula or a catheter can be connected to the connecting head, a spray head or a spray device connect by means of which can be components of the mixing and spraying. The atomization of the components can take place in a purely mechanical manner (by appropriate design of the outlet openings) or using the medmischen gas.
The above-described in Zusammehang with the applicator of the invention are applicable to all accordingly to the mounting device as such, which is also subject matter of the invention.
Hereinafter, a exemplary embodiment will play the invention illustrated by the figures. In detail:
Fig. 1 is a side view of the on ragvorrichtung with dash-dotted lines, indicated hand gripping the m - position for holding and actuating the application device,
Fig. 2 is a sectional view of the applicator taken along line II -II of Fig. 1 and
Fig. 3 is a perspective view of the coupling element and in exploded view of Halterungsvomchtung.
Fig. 1 shows a side view of an applicator device 10 for multi-component tissue glue. The application device 10 comprises two supply containers in the form of commercially available syringes 12 for solutions of proteins, and blood-clotting factors ge mnungsfördernden a Zweikompo--component tissue glue. Each syringe 12 is provided with a hollow cylindrical syringe body 14 having a front end 16 having a discharge port 18 and port 20 and an open rear end 22nd In each syringe body 14 is a sealingly abutting against the inner surface of the syringe body 14. Piston 24 is disposed, which is held by a piston rod 26 which is passed through the rear end 22 led out of the syringe body fourteenth The piston rods 26 extend respectively in the longitudinal extension of the syringe body 14 (see. The direction indicated in the figures, longitudinal axes 28 of the syringe body 14). The piston 24 facing away from the free ends 30 of the piston rod 26 are provided with annular flanges 32nd The annular flanges 32 are connected via a connecting element 34 with each other mechanically. The connecting element 34 is provided with two receiving recesses 36 which are open at the side and into which the annular flanges 32 are inserted.
a connecting headpiece 38 is placed on the slightly conical connection piece 20 at the front ends 16 of the syringe body fourteenth The connecting headpiece 38 is provided with built-in dot-dash lines through channels 40 thereof facing the syringe bodies 14 receiving socket 42 the socket 20 of the Spritzenkörepr are spaced apart corresponding to 14 and to which the syringe bodies 14 facing away from the discharge end 44 are immediately adjacent aneinander-. Further, the connecting headpiece 38 to a further channel 46, to which a medical gas (eg, 0 2) leading hose is connected 48th Also this channel 46 ends at the output end 44 in close proximity to the other two channels 40. The connecting head 38 is provided with a triple-lumen catheter 50, the three lumens are aligned with the three channels 40 and 46 of connecting headpiece 38th The two syringe bodies 14 are shown in FIGS means of a clip holder device (hereinafter referred to as holding member) 52 joined together. The holding member 52 is provided with retaining clips 54, two C-shaped, the openings 56 are facing away from each other and which are connected in their central portions with each other
(See also Fig. 2). The openings 56 have the extension of the plane 58, in which the longitudinal axis 28 of the syringe body 14 are located in direction. Undergripping -Vorsprünge 60 are connected to the holding clamps 54 These projections 60 extend in mutually opposite directions, being rotated 90 ° to the two holding clips 54 and their openings are arranged 56th The two projections 60 protrude so that in each case at right angles out of the plane 58 out, in which the longitudinal axes 28 of the syringe body 14 are in the held by the holding member 52 state and extending in the coinciding with the longitudinal axes 28 of the syringe body 14 longitudinal axis of the terminals 54th Thus, the projections 60 in the opposite direction extending along the axis of symmetry 62 of the double -Klemmenanordnung
The syringe body 14 are mounted sliding displaceable on the retaining member 52 because the resilient holding clamps 54 extend around more than 180 ° and preferably up to 200 ° around the syringe body 14, which enclose them with a clamping force which permits a relative displacement. The holding member 52 is located on laterally projecting flanges 64 at the rear ends 22 of the syringe body 14, whereby a stop between the holding element 52 and syringe body is given fourteenth The axial extent of the holding element 52 and especially of the holding clamps 54 is such that the outwardly disposed to the syringe bodies 14 scaling remains free and is not covered. The entire device 10 including the connection head 38 is made of plastic.
The hand position during handling for holding and actuating the apparatus 10 is indicated in FIG. 1. The device 10, ie, the double syringes assembly of the device 10 is held between the index and middle fingers 66,68 of one hand 70 while the thumb rests 72 of the hand 70 on the connecting element 34th The projections 60 of the holding member 52 are of the index and middle fingers 66,68 of the hand at the connection member 34 side facing away from the projections 60 to 70 underclings, ie they are. When pressing on the connecting element 34 with the thumb 72, the pistons are advanced toward the front ends 16 of the syringe body 14 24, wherein the retaining member 52 is an abutment or a stop in the flanges 64th How to detect on the basis of Fig. 1, the index and middle fingers 66,68 only need to be spread wide to the outer diameter of the syringe body 14 corresponding to handle the device 10. This is noticeably lighter than if the finger at the level of the greatest transverse extension of the device 10 (ie, two times of an outer diameter of the syringe body 14 plus the distance that have both syringe body 14 from each other) must be spread 66,68. So that the device described and illustrated in the drawing 10 especially for people with small hands is quite easy to handle.
As reference to FIGS. can be seen 1 and 2, the holding member 52 and the connecting head piece 38 by means of a coupling element 74 are connected to each other. The coupling member 74 has a surrounding part 76 and an integrally verbündendes with this connecting part 78, whose free end 80 is connected to the holding member 52 (see also Fig. 3). The surrounding part 76 has two environmental gripping zones 82 which are each open through up to 270 ° extending resilient circular bracket 84 formed as and at 86th Both openings 86 exhibit the same direction at substantially. The two round strap 84 are connected together in one piece via a web 88th
With its two openings 86, the surrounding part 76 can attach laterally onto the receiving connector 42 of the connecting headpiece 38th The rotary bracket 84 engage behind the receiving socket 42 formed radial protrusions 90 which are formed schlusεes as male parts of a Luer lock comparison. For fixed to the holding member 52. Associated connecting element 78 and the receiving connector 42 plugged surrounding part 76 so that the connecting head piece 38 is secured against unintentional detachment of the nozzle 20 of the syringe body fourteenth
78 at its free end 80, the connecting part of FIG. 3 on a plurality of locking projections 92. The coupling of the connecting part 78 with the holding member 52 is effected in that the free (snap) is inserted end 80 of the connecting member 78 in a bore 94 of the holding member 52nd This bore 94 is formed 60 of the holding member 52 in one of the two (sub) gripping orSprüngen, in the (internal} area 96 of the projection 60, which area 96 by the two C-shaped holding clamps 54 and the back part 57 the locking projections 92 is limited. snag in the bore 94 and engage behind the edge of the the surrounding part 76 side facing away from the holding member 52. the further the free end 80 of the connecting part is pushed through the bore 94 78, the shorter the distance is between the surrounding part 76 and the holding member 52. Thus, the effective length of the coupling element 74 allows the distance between the radial projections 90 of connecting headpiece 38 (which must be engaged from behind by the surrounding part 76) and the flanges 64 of the syringe body 14 (on which the holding element 52 should fit) to adjust.
Application apparatus for applying a multiple component tissue adhesive, with several supply containers (14) in each case one
Fluid component, in particular a fuel component Gewebekleb-, wherein each storage container (14) having a front end (16,20) with an opening (18) for outputting the respective fluid component and a rear end opposite thereto
(22) and a sliding manner in the storage container
(14) arranged piston (24) having an out of the rear end (22) projecting piston rod to an actuating end for actuating the piston
(24), a connecting head (38) receiving socket (42) for the front ends (16,20) of the storage containers (14), through the connecting head piece (38) between the receiving connection piece (42) and an output end ( 44) for simultaneously outputting all the fluid components (channels 40,46) extend for the individual fluid components and wherein the receiving connection piece (42) (with radially outwardly directed projections 90) are provided, a support device (52) for holding said supply containers (14) the region of their rear ends (22), wherein the holder device (52) is positionable between the fingers (66,68) of a hand (70), and a coupling member (74) for releasably connecting the holder device (52) to the connecting headpiece (38 ), wherein the coupling member (74) includes a surrounding part (76) having a plurality Umgreifzonen (82) for at least partially engaging around the receiving socket (42) and to bear against the Halterungsvorricht having ung (52) of the projections (92) of the receiving connection piece (42) facing away.
2. Applicator device according to claim 1, characterized in that the Umgreifzonen (82) for laterally pushing on the receiving connection piece (42) are elastic.
3. The application device according to claim 1 or 2, characterized in that each Umgreifzone (82) has a over a Wmkelbereich between about 200 ° and about 300 ° extending elastic strap (84).
4. Applicator according to one of claims 1 to 3, characterized in that each Umgreifzone (82) as a curved bracket (84) is formed, and that all of these brackets (84) are connected together.
5. Applicator according to one of claims 1 to 4, characterized in that the coupling element (74) comprises a connecting part (78) with the surrounding part (76) and the mounting device (52) is connected.
6. The application device according to claim 5, characterized in that the connecting part (78) integral with the surrounding part (76) and a said surrounding part (76) opposite end (80) with at least one latching projection (92) for snap coupling to the mounting device (52).
7. Coating device according to claim 5, characterized in that the mounting device (52) comprises a comparison detent hole (94) in which the provided with the at least one latching projection (92) end (80) of the comparison bmdungsteils (78) against unintended solve em be plugged.
8 comprises applicator according to claim 6 or 7, characterized in that the connecting part (78) a plurality of locking projections (92) in the longitudinal extent of the connecting part (78) are successively arranged.
9. Applicator according to one of claims 1 to 8, characterized in that the projections (90) of the receiving connection piece (42) of the connecting headpiece (28) are designed as annular flanges.
10. The application device according to claim 9, characterized in that the annular flanges are formed as a male Luer-lock fasteners.
11. Applicator according to one of claims 1 to 10, characterized in that the mounting device
(52) each facing away from extending projections (60) for gripping with the fingers (66,68) having a hand (70) and that the projections (60) protrude out of the plane (58) m of the (from the Halterungsvomchtung 52 ) supply containers held (14) are arranged.
12. Applicator according to one of claims 1 to 11, characterized in that the Halterungsvomchtung
(52) retainer housings, m the impressively the advantages rats containers (14) and / or latched
13. Applicator according to one of claims 1 to 12, characterized in that the mounting device
(52) and the storage containers (14) Anschlagemrich- obligations for limiting a relative movement of the mounting device (52) and the storage containers (14) in the direction of their rear ends (22).
14. Applicator according to one of claims 1 to 13, characterized in that the storage containers
(14) slidably by the holder device (52) are held.
15. Applicator according to one of claims 1 to 14, characterized in that the storage containers
(14) at their rear ends (22) with protruding flanges (64) are provided, in contact with which the mounting devices (52) are engageable.
16. Applicator according to one of claims 1 to 15, characterized in that the mounting device
(52) two interconnected to opposite sides open towards symmetrically disposed C-shaped clamps (54) for clampingly engaging around two supply containers (14) each with more than 180 °, and in that with the two connected egg-shaped clamps (54 ) two away from each other directed protrusions (60) are connected, extending along the axis of symmetry (62) of the two C-shaped clamps (54).
17. Applicator according to one of claims 1 to 16, characterized in that associated with the storage, the containers (14) the piston rods (26) for common actuation of a connecting element (34) are connected.
18. The application device according to claim 17, characterized in that the connecting element (34) has lateral open receiving spaces (36) for pushing onto the free ends (30) of the piston rod disposed (26) flanges (32).
19. Applicator according to one of claims 1 to 18, characterized in that the coupling element and / or the holder device (52) consists of an elastic material, in particular plastic material.
20. Applicator according to one of claims 1 to 19, characterized in that the connecting headpiece
(38) has a gas connection for the supply of medical gas, and an extending from the gas connection of up to the output end (44) channel (46).
21. Applicator according to one of claims 1 to 20, characterized in that at the discharge end (44) of the connecting headpiece (38) is connected to a cannula, in particular a catheter (50).
22. Holder for an applicator device for applying a multi component fluid, especially a multi-component tissue glue, comprising a holder device (52) for holding storage containers (14) for the individual fluid components, wherein the mounting device (52) between the fingers (66,68) of a hand (70) is positionable, and a coupling member (74) for releasably connecting the holder device (52) with a connecting head (38) to which the storage containers
(14) can be coupled and which is provided for the simultaneous dispensing of all the fluid components, coupling socket and the coupling member (74) a surrounding part (76) having a plurality Umgreifzonen (82) for partially embracing of with outer projections (90) provided (42) of the connecting headpiece (38 ) and (for engaging behind the outer projections 90) of the coupling piece (42) of the connecting headpiece has.
23. Holder according to claim 22, characterized in that the Umgreifzonen (82) for lateral sliding on the coupling piece (42) are elastic.
24. Holder according to claim 22 or 23, characterized in that each Umgreifzone (82) has a through an angle range between about 200 ° and about 300 ° extending elastic strap (84).
25. Holder according to one of claims 22 to 24, characterized in that each Umgreifzone (82) as a curved bracket (84) is formed, and that all of these brackets (84) are connected together.
26. Holder according to one of claims 22 to 25, characterized in that the coupling element (74) comprises a connecting part (78) with the reach-round part (76) and the mounting device (52) is connected.
27. Holder according to claim 26, characterized in that the connecting part (78) integral with the surrounding part (76) is connected to the surrounding part and a
(76) opposite end (80) with at least one latching projection (92) for snap coupling to the mounting device (52).
28. Holder according to claim 26, characterized in that the holder device (52) a Verrastloch
(94) into which the fitted with the at least one latching projection (92) end (80) of the connecting part (78) is insertable against unintentional loosening.
29 support comprises (92) of claim 27 28, characterized in that the connecting part (78) projections of a plurality of locking, which in the longitudinal extent of the connecting part (78) are successively arranged.
30 has Holder according to one of claims 22 to 29, characterized in that the holder device (52) facing away from each other, extending projections (60) for gripping with the fingers (66,68) of a hand (70) and that the projections (60 ) out of the plane
(58) project, are arranged in the held by the holding device (52) storage containers (14).
31. Holder according to one of claims 22 to 30, characterized in that the holder device (52) is provided with retainer housings, into which the storage containers (14) crimping and / or can be latched.
32. Holder according to one of claims 22 to 31, characterized in that the mounting device (52) is designed for abutment against stops at the storage containers (14).
33. Holder according to one of claims 22 to 32, characterized in that the storage containers (14) are held same tend displaced from the holder device (14).
34. Holder according to one of claims 22 to 33, characterized in that the mounting device (52) comprises two interconnected to opposite sides open towards symmetrically disposed C-shaped clamps (54) for clampingly engaging around two supply containers (14) having in each case more than 180 °, and that the two associated C-shaped clamps (54) comprises two apart from each other directed protrusions (60) are connected, extending along the axis of symmetry (62) of the two C-shaped clamps
(54) extend.
35. Holder according to one of claims 22 to 34, characterized in that in supply containers (14) each having a piston (24) and this supporting piston rod (26) (a the free ends (30) of the piston rods (26) connecting element connecting 34) is provided.
having 36. Holder according to claim 35, characterized in that the connecting element (34) laterally open receiving spaces (36) arranged for pushing onto the free ends (30) of the piston rod (26) flanges (32).
37. Holder according to one of claims 22 to 36, characterized in that the mounting device (52) and / or the coupling element (74) made of an elastic material, in particular plastic material.
PCT/EP1997/004919 1996-09-10 1997-09-09 Multicomponent tissue adhesive application device and holder for such device WO1998010704A1 (en)
DE19636622.4 1996-09-10
JP51324298A JP2001504716A (en) 1996-09-10 1997-09-09 Application device for supplying a multicomponent tissue glue, and the cage for the application device
EP19970909236 EP0925027A1 (en) 1996-09-10 1997-09-09 Multicomponent tissue adhesive application device and holder for such device
WO1998010704A1 true WO1998010704A1 (en) 1998-03-19
DE29509729U1 (en) * 1994-07-05 1995-08-31 Immuno Ag Adapter sleeve and catheter assembly with such adapter sleeve
EP0217856B1 (en) 1990-03-14 Bicycle chain lubricating &amp; cleaning apparatus
KR930009712B1 (en) 1993-10-09 Bone stapler cartridge
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