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LLM-Enzyme-Kinetics-Archive-LLENKA

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train · 35.6k rows

Enzyme stringlengths 4 59	Organism stringlengths 1 70	Substrate stringlengths 1 86	km float64 0 1.4M ⌀	Unit_Km stringclasses 65 values	Kcat stringlengths 1 16	Unit_Kcat stringclasses 134 values	Kcat/Km stringlengths 1 21	Unit_Kcat/Km stringclasses 335 values	Commentary[Temp] stringclasses 165 values	Commentary[pH] stringclasses 225 values	Commentary[Mutant] stringlengths 1 93	Commentary[Cosubstrate] stringlengths 1 89	pubmed id float64 1.5M 35.5M ⌀
Selenocysteine methyltransferase	Astragalus bisulcatus	L-Selenocysteine	0.7	mM	6.2 × 10^-3	s^-1	8.9	M^-1s^-1				S-adenosylmethionine	10,026,151
Selenocysteine methyltransferase	Astragalus bisulcatus	DL-Selenohomocysteine	0.35	mM	7.4 × 10^-3	s^-1	21	M^-1s^-1				S-adenosylmethionine	10,026,151
Homocysteine methyltransferase (YagD)	Escherichia coli	L-Homocysteine	0.045	mM	0.38	s^-1	8.5 × 10^3	M^-1s^-1				S-adenosylmethionine	10,026,151
Homocysteine methyltransferase (YagD)	Escherichia coli	L-Selenocysteine	0.59	mM	1.7 × 10^-4	s^-1	0.29	M^-1s^-1				S-adenosylmethionine	10,026,151
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	0.6	µM	0.09	s^-1	0.14 × 10^6	M^-1s^-1	1°C	5.7			10,026,271
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	2.1	µM	3.3	s^-1	1.5 × 10^6	M^-1s^-1	30°C	5.5			10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	20,000	mM	0.006	s^-1	0.28	M^-1s^-1	30°C	5.5			10,026,271
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	null						1°C	6.0		5 µM EDTA	10,026,271
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	null						1°C	6.0		25 µM DPA	10,026,271
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	null						1°C	6.0		7 µM ZnSO4	10,026,271
LpxC	Escherichia coli	UDP-3-O-acyl-GlcNAc	null						30°C	5.5		24 µM ZnSO4	10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Apo-LpxC		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Zn2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Cd2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Ca2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Cu2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Mg2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Mn2+-reconstituted		10,026,271
LpxC	Escherichia coli	UDP-GlcNAc	null						30°C	5.7	Ni2+-reconstituted		10,026,271
Aps1	Schizosaccharomyces pombe	Ap6A	19.1	µM	2.0	s^-1	1.0 × 10^5	M^-1s^-1	37°C	7.6		1 mM MnCl2	10,090,752
Pus1	Saccharomyces cerevisiae	tRNA^Val	420	nM	0.4	min^-1							10,356,324
Pus1	Saccharomyces cerevisiae	tRNA^Ile	740	nM	0.5	min^-1							10,356,324
hMTH1	Homo sapiens	2-OH-dATP	8.3	µM	13.9	s^-1	1.68	s^-1·µM^-1	30°C	8.0			10,373,420
hMTH1	Homo sapiens	8-OH-dGTP	15.2	µM	12.3	s^-1	0.81	s^-1·µM^-1	30°C	8.0			10,373,420
hMTH1	Homo sapiens	8-OH-dATP	13.9	µM	10.8	s^-1	0.78	s^-1·µM^-1	30°C	8.0			10,373,420
hMTH1	Homo sapiens	dGTP	258	µM	15.7	s^-1	0.06	s^-1·µM^-1	30°C	8.0			10,373,420
hMTH1	Homo sapiens	2-OH-dATP	5.7	µM	4.7	s^-1	0.83	s^-1·µM^-1	30°C	7.2			10,373,420
hMTH1	Homo sapiens	8-OH-dGTP	12.8	µM	2.1	s^-1	0.16	s^-1·µM^-1	30°C	7.2			10,373,420
hMTH1	Homo sapiens	8-OH-dGTP	null						30°C	7.2-8.8			10,373,420
hMTH1	Homo sapiens	2-OH-dATP	null						30°C	7.2-8.8			10,373,420
MutT	Escherichia coli	8-OH-dGTP	null						30°C	7.5			10,373,420
MutT	Escherichia coli	dGTP	null						30°C	7.5			10,373,420
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	1	µM	6.0	s^-1	6.0	µM^-1s^-1	28°C	7.8	WT	5 mM MgCl2	10,383,414
Tyrosyl-tRNA synthetase	Escherichia coli	D-Tyr-tRNA^Tyr	0.2	µM	1.5 × 10^-3	s^-1	7.5 × 10^-3	µM^-1s^-1	28°C	7.8	WT		10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	None	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	5 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	10 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	20 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	50 mM KCl	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	200 mM KCl	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	400 mM KCl	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	5 mM MgCl2 + 50 mM KCl	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	5 mM MgCl2 + 0.1 mM ZnCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	1 mM spermidine	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	5 mM spermidine	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null						28°C	7.8	WT	10 mM spermidine	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	D-Tyr-tRNA^Tyr	null		6.0	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	L-Tyr-tRNA^Tyr	null		< 10^-3	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	N-Acetyl-D-Tyr-tRNA^Tyr	null		< 10^-3	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
D-Tyr-tRNA^Tyr deacylase	Escherichia coli	N-Acetyl-L-Tyr-tRNA^Tyr	null		< 10^-3	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
Peptidyl-tRNA hydrolase	Escherichia coli	D-Tyr-tRNA^Tyr	null		0.016	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
Peptidyl-tRNA hydrolase	Escherichia coli	L-Tyr-tRNA^Tyr	null		0.006	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
Peptidyl-tRNA hydrolase	Escherichia coli	N-Acetyl-D-Tyr-tRNA^Tyr	null		0.003	µM^-1s^-1			28°C	7.8	WT	5 mM MgCl2	10,383,414
Mj0226	Methanococcus jannaschii	XTP	0.1	mM	1009.37	s^-1	10195.66	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	ITP	0.15	mM	911.72	s^-1	5998.16	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	GTP	1.11	mM	97.65	s^-1	87.66	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	dGTP	1.13	mM	96.64	s^-1	85.52	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	ATP	7.04	mM	1.02	s^-1	0.15	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	CTP	1.45	mM	2.23	s^-1	1.54	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
Mj0226	Methanococcus jannaschii	TTP	0.3	mM	1.77	s^-1	5.90	mM^-1s^-1	80°C	7.6	WT	Mg^2+	10,404,228
β-Glycosidase	Sulfolobus solfataricus	o-nph-β-D-Galp	1	mM	24	s^-1	24	s^-1/mM	30°C	7.4			10,467,170
β-Glycosidase	Sulfolobus solfataricus	o-nph-β-D-Galp	0.5	mM	55	s^-1	110	s^-1/mM	30°C	7.4		80 mM 1-butanol	10,467,170
β-Glycosidase	Sulfolobus solfataricus	o-nph-β-D-Galp	4	mM	1320	s^-1	330	s^-1/mM	75°C	7.4			10,467,170
β-Glycosidase	Sulfolobus solfataricus	o-nph-β-D-Galp	11	mM	1450	s^-1	131.88	s^-1/mM	75°C	7.4		80 mM 1-butanol	10,467,170
SsuE	Escherichia coli	FMN	0.054	µM			474.1	min^-1µM^-1	30°C	7.9		NADH	10,480,865
SsuE	Escherichia coli	FAD	2.7	µM			16.9	min^-1µM^-1	30°C	7.9		NADH	10,480,865
SsuE	Escherichia coli	NADPH	46	µM			33.4	min^-1µM^-1	30°C	7.9		FMN	10,480,865
SsuE	Escherichia coli	NADH	555.5	µM			0.1	min^-1µM^-1	30°C	7.9		FMN	10,480,865
SsuD	Escherichia coli	Decanesulfonic acid	35	µM			6.7	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	Octanesulfonic acid	44	µM			6.1	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	1,3-Dioxo-2-isoindolineethanesulfonic acid	114	µM			6.0	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	2-(4-Pyridyl)ethanesulfonic acid	139	µM			4.6	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	Hexanesulfonic acid	95	µM			4.0	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	N-Phenyltaurine	237	µM			3.2	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	4-Phenyl-1-butanesulfonic acid	110	µM			2.7	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	Pentanesulfonic acid	189	µM			1.8	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	MOPS	617	µM			1.1	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
SsuD	Escherichia coli	Butanesulfonic acid	870	µM			0.6	min^-1µM^-1	30°C	9.1		FMNH2, O2	10,480,865
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	0.18	mM	3500	s^-1	1.9 × 10^7	M^-1s^-1	23°C	7.3	WT		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	1.6	mM	40	s^-1	2.5 × 10^4	M^-1s^-1	23°C	7.3	R11A		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	0.29	mM	28	s^-1	9.7 × 10^4	M^-1s^-1	23°C	7.3	R39A		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	0.47	mM	9.0	s^-1	1.9 × 10^4	M^-1s^-1	23°C	7.3	R39Q		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	null		≤0.4	s^-1			23°C	7.3	R11A/R39A		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-hexadienedioate	0.29	mM	3500	s^-1	1.2 × 10^7	M^-1s^-1	23°C	7.3	R61A		10,493,802
4-oxalocrotonate tautomerase	Pseudomonas putida mt-2	2-hydroxy-2,4-pentadienoate	1.11	mM	0.40	s^-1	3.6 × 10^2	M^-1s^-1	23°C	7.3	WT		10,493,802
TruB	Escherichia coli	[5-3H]tRNA	146	nM	0.12	s^-1	7.5 × 10^5	M^-1s^-1	37°C	7.5	Wild-type		10,529,181
TruB	Escherichia coli	[5-3H]tRNA	177	nM	0.26	s^-1	1.5 × 10^6	M^-1s^-1	37°C	7.5	C58A		10,529,181
TruB	Escherichia coli	[5-3H]tRNA	127	nM	0.16	s^-1	1.3 × 10^6	M^-1s^-1	37°C	7.5	C174A		10,529,181
TruB	Escherichia coli	[5-3H]tRNA	218	nM	0.18	s^-1	8.3 × 10^5	M^-1s^-1	37°C	7.5	C193V		10,529,181
TruB	Escherichia coli	[5-3H]tRNA	124	nM	0.11	s^-1	8.9 × 10^5	M^-1s^-1	37°C	7.5	C58A/C174A/C193A		10,529,181
RluA	Escherichia coli	[5-3H]tRNA	108	nM	0.099	s^-1	9.2 × 10^5	M^-1s^-1	37°C	7.5	Wild-type		10,529,181
RluA	Escherichia coli	[5-3H]tRNA	420	nM	0.070	s^-1	1.7 × 10^5	M^-1s^-1	37°C	7.5	C117A		10,529,181
RluA	Escherichia coli	[5-3H]tRNA	160	nM	0.15	s^-1	9.4 × 10^5	M^-1s^-1	37°C	7.5	C128A		10,529,181
Catalase-peroxidase	Synechocystis PCC 6803	H2O2	4.9	mM	3500	s^-1	7.1 × 10^5	M^-1s^-1		7.0	Recombinant		10,543,446
Catalase-peroxidase	Synechocystis PCC 6803	Peroxoacetic acid	null		8.74 × 10^3	M^-1s^-1			15°C	7.0	Recombinant		10,543,446
Catalase-peroxidase	Synechocystis PCC 6803	o-dianisidine	null		2.71 × 10^6	M^-1s^-1			15°C	7.0	Recombinant		10,543,446
Catalase-peroxidase	Synechocystis PCC 6803	Pyrogallol	null		8.62 × 10^4	M^-1s^-1			15°C	7.0	Recombinant		10,543,446
Catalase-peroxidase	Synechocystis PCC 6803	Ascorbate	null		5.43 × 10^3	M^-1s^-1			15°C	7.0	Recombinant		10,543,446
Catalase-peroxidase	Synechocystis PCC 6803	NaCN	null		4.8 × 10^5	M^-1s^-1					Recombinant		10,543,446
PQQGDH-B	Acinetobacter calcoaceticus	Glucose	26.8	mM	3436	s^-1	128	s^-1 mM^-1			Wild type		10,544,015

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