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<s>[INST] Does prednisolone reduce TNF-alpha release by PBMCs activated with a trifunctional bispecific antibody but not their anti-tumor activity? [/INST] yes, The in vivo application of bispecific antibodies for adjuvant tumor therapies may be limited by the manifest activation of immune effectors, accompanied by overwhelming cytokine release. Glucocorticoids, like prednisolone, may effectively reduce cytokine release without impairing the antitumor activity of trAb-activated immune cells. The source for this answer is PMID: 16309222. </s>

<s>[INST] Does dietary carbohydrate modification enhance insulin secretion in persons with the metabolic syndrome? [/INST] yes, Rye bread and pasta-based carbohydrate modification enhances early insulin secretion in persons with the metabolic syndrome, which may lower the risk of deteriorating glucose tolerance and development of type 2 diabetes. The source for this answer is PMID: 16332654. </s>

<s>[INST] Does recombinant human growth hormone improve muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients? [/INST] yes, rhGH improves whole-body protein homeostasis in chronic hemodialysis patients. The source for this answer is PMID: 16332656. </s>

<s>[INST] Do [ Validation of the AUDIT test for identifying risk consumption and alcohol use disorders in women ]? [/INST] yes, The AUDIT is a questionnaire with good psycho-measurement properties. It is reliable and valid for the detection of risk consumption and DS in women. The source for this answer is PMID: 16324508. </s>

<s>[INST] Does the induction of heme oxygenase 1 decrease contractility in human internal thoracic artery and radial artery grafts? [/INST] yes, Hemin caused in vitro induction of heme oxygenase 1 in human internal thoracic artery and radial artery grafts. This induction resulted in a reduced contractility to norepinephrine, partially through the cyclic guanosine monophosphate-dependent pathway. This effect was independent from nitric oxide synthesis. The source for this answer is PMID: 16308001. </s>

<s>[INST] Do efficient analysis and extraction of MS/MS result data from Mascot result files? [/INST] yes, The database upload allows regrouping of the MS/MS results using a database management system and complex analyzing queries using SQL without the need to run new Mascot searches when changing grouping parameters. The source for this answer is PMID: 16336652. </s>

<s>[INST] Do amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice? [/INST] yes, Islets from diabetic mice show some mis-regulation of intracellular pH, and their secretory capacity is consistently enhanced by DMA/amiloride. Thus, amiloride derivatives show promise as potential therapeutic agents for type 2 diabetes. The source for this answer is PMID: 16336655. </s>

<s>[INST] Is biphasic effect of extracellular ATP on human and rat airways due to multiple P2 purinoceptor activation? [/INST] yes, Extracellular ATP induces a transient contractile response in human and rat airways, mainly due to P2X receptors and extracellular Ca2+ influx in addition with, in IPB, P2Y receptors stimulation and Ca2+ release from intracellular Ca2+ stores. Extracellular Ca2+ influx occurs through L-type voltage-dependent channels activated by external Na+ entrance through P2X receptors. The transience of the response cannot be attributed to ATP degradation but to purinoceptor desensitization and, in extrapulmonary airways, prostaglandin-dependent PKA activation. The source for this answer is PMID: 16336659. </s>

<s>[INST] Do landiolol and esmolol prevent tachycardia without altering cerebral blood flow? [/INST] yes, Landiolol suppresses heart rate elevation during ECT without affecting blood pressure. Cerebral blood flow velocity in the middle cerebral artery is not affected by the use of either esmolol or landiolol. The source for this answer is PMID: 16326671. </s>

<s>[INST] Does spatiogenetic characteristics of beech stand with different degrees of autochthony? [/INST] yes, The surprisingly high correspondence between our descriptors of spatiogenetic structure and forest management types confirms the appropriateness of the applied measure of cluster isolation and of the criterion for the choice of the level alpha of cluster isolation. The two types of cluster structure and their characteristic descriptors are thus suggested to be promising tools for the detection of subpopulation structure. To include the effects of long-distance gene flow, the presented methods can be extended as outlined to larger spatial scales in order to detect higher order population structure. The source for this answer is PMID: 16332257. </s>

<s>[INST] Do evidence for overlap between idiopathic environmental intolerance and somatoform disorders? [/INST] yes, The similarity of IEI and SFD regarding symptoms and psychological features of somatization support the hypothesis that IEI is a variant of SFD. The source for this answer is PMID: 16314597. </s>

<s>[INST] Is the G protein-gated potassium current I ( K , ACh ) constitutively active in patients with chronic atrial fibrillation? [/INST] yes, Our results demonstrate that larger basal inward rectifier K+ current in cAF consists of increased IK1 activity and constitutively active I(K,ACh). Blockade of I(K,ACh) may represent a new therapeutic target in AF. The source for this answer is PMID: 16330682. </s>

<s>[INST] Are antibodies of IgM subclass to phosphorylcholine and oxidized LDL protective factors for atherosclerosis in patients with hypertension? [/INST] yes, High levels of IgM-antibodies against PC and OxLDL predict a favourable outcome in the development of carotid atherosclerosis in hypertensive subjects. Whether these antibodies could be used therapeutically deserves further study. The source for this answer is PMID: 16307748. </s>

<s>[INST] Does apoA-I/phosphatidylcholine discs remodel fast-migrating HDL into slow-migrating HDL as characterized by capillary isotachophoresis? [/INST] yes, ApoA-I/POPC discs remodeled cITP fHDL and iHDL to sHDL independent of LCAT activity. The source for this answer is PMID: 16307746. </s>

<s>[INST] Do clinical features remain important for the diagnosis of infective endocarditis in the modern era? [/INST] yes, Clinical features at presentation continue to be important for the diagnosis of IE. Features such as positive blood cultures, signs of embolism and a changing heart murmur should be used to guide investigation and treatment of IE prior to echocardiography, or when TTE is negative. The source for this answer is PMID: 16330508. </s>

<s>[INST] Is regular aspirin-use preceding the onset of primary intracerebral hemorrhage an independent predictor for death? [/INST] yes, We observed poor short-term outcomes and increased mortality, probably attributable to rapid enlargement of hematomas, in the subjects with ICH who had been taking regularly moderate doses of aspirin (median 250 mg) immediately before the onset of the stroke. The source for this answer is PMID: 16322483. </s>

<s>[INST] Is intracerebral hemorrhage-induced brain injury aggravated in senescence-accelerated prone mice? [/INST] yes, These results suggest that activated microglia/monocytes may aggravate intracerebral hemorrhagic damage in old SAMP8 mice. Further studies on the exact role of activated microglia/monocytes and the altered activities of antioxidant enzymes in old SAMP8 mice may provide useful information for ICH-induced brain injury in relation with aging. The source for this answer is PMID: 16322488. </s>

<s>[INST] Does tramadol impair the phagocytic capacity of human peripheral blood cells? [/INST] no, The lack of noxious effect of tramadol on the engulfing capacity of phagocytic cells suggests additional benefit to the relatively safe profile of the drug. The source for this answer is PMID: 16326672. </s>

<s>[INST] Does infiltration with ropivacaine plus lornoxicam reduce postoperative pain and opioid consumption? [/INST] yes, Wound infiltration with ropivacaine 0.75% plus lornoxicam 8 mg combination improved postoperative pain control and patient comfort, and decreased the need for opioids than the use of either drug alone. The source for this answer is PMID: 16326674. </s>

<s>[INST] Does creatine supplementation reduce muscle inosine monophosphate during endurance exercise in humans? [/INST] yes, Raising muscle total Cr content before exercise appears to improve the ability of the muscle to maintain energy balance during intense aerobic exercise, but not during more moderate exercise intensities. The source for this answer is PMID: 16331129. </s>

<s>[INST] Does desipramine attenuate working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex? [/INST] yes, These data suggest that moderate loss of DA and NE in the prefrontal cortex is sufficient to impair cognitive function, and these behavioral effects are attenuated by inhibition of the NE transporter. The source for this answer is PMID: 16307295. </s>

<s>[INST] Does montelukast improve pulmonary function measured by impulse oscillometry in children with asthma ( Mio study )? [/INST] yes, Montelukast improves central and especially peripheral airways function in the first month of treatment, as evaluated by IOS, a technique based on tidal breathing analysis which is more sensitive than conventional forced spirometry. The source for this answer is PMID: 16330196. </s>

<s>[INST] Does [ correlate of self-rated fatigue in Korean employees ]? [/INST] yes, These results suggest that fatigue has been considered as a common complaint, and that it is affected by job-related factors like work hours and the workplace size as well as sociodemographics or health-related behaviors. Further research is needed to clarify the effects of fatigue on adverse health,outcomes, work performance, work disability, sick absence and medical utilization, and to examine the relationship of job characteristics (e.g.: work demand, decision latitude) to fatigue. The source for this answer is PMID: 16312912. </s>

<s>[INST] Does p38 mitogen activated protein kinase mediate both death signaling and functional depression in the heart? [/INST] yes, The p38 MAPK pathway indeed mediates the following important events in myocardial apoptosis and functional depression: mitogen-activated protein kinase-activated protein kinase 2, caspase-1, caspase-3 and caspase-11 activation, and tumor necrosis factor, interleukin-1beta, interleukin-6 production after myocardial ischemia. Single site (p38 MAPK) inhibition of these events may have important therapeutic implications in myocardial protection. The source for this answer is PMID: 16305880. </s>

<s>[INST] Do the deflation limb of the pressure-volume relationship in infants during high-frequency ventilation? [/INST] yes, Using current ventilation strategies, all infants were being ventilated near the inflation limb. It is possible to delineate the deflation limb in infants receiving high-frequency oscillatory ventilation; in doing so, greater lung volume and oxygenation can be achieved, often at lower airway pressures. The source for this answer is PMID: 16322649. </s>

<s>[INST] Do cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats? [/INST] yes, Genioglossus responses to manipulation of cAMP at the HMN are differentially modulated by sleep-wake state. Selective abolition of serotonin and phenylephrine responses after IBMX suggests that under conditions of nonspecific phosphodiesterase inhibition the HMN is unresponsive to certain, otherwise potent, excitatory inputs. Similar responses with 8-Br-cGMP suggest this effect is likely mediated by cGMP pathways. The source for this answer is PMID: 16322643. </s>

<s>[INST] Does intranasal exposure to Stachybotrys chartarum enhance airway inflammation in allergic mice? [/INST] yes, Exposure to S. chartarum modulates the inflammatory reaction and airway hyperresponsiveness, depending on the allergic status of the exposed mice. The source for this answer is PMID: 16322647. </s>

<s>[INST] Does acute sustained hypoxia suppress the cough reflex in healthy subjects? [/INST] yes, Acute isocapnic hypoxia suppresses cough reflex sensitivity to inhaled capsaicin. This finding raises the possibility that the cough reflex may be impaired during acute exacerbations of hypoxic-respiratory disorders. The source for this answer is PMID: 16322644. </s>

<s>[INST] Does [ The experimental research on the use of triamcinolone acetonide for the prevention of implant capsular contracture ]? [/INST] yes, It is effective to deliver triamcinolone acetonide to reduction of capsular contracture through the catheter and its pot. The source for this answer is PMID: 16335385. </s>

<s>[INST] Is the PTPN22 620W allele a risk factor for Wegener 's granulomatosis? [/INST] yes, The PTPN22 620W allele appears to be involved in the pathogenesis of WG, and ANCA positivity seems to be the hallmark. The source for this answer is PMID: 16320352. </s>

<s>[INST] Do apple- and hop-polyphenols protect periodontal ligament cells stimulated with enamel matrix derivative from Porphyromonas gingivalis? [/INST] yes, These results suggest that AP, ACT, AP, HBP, and HMW-HBP protect EMD-stimulated PDL cells from P. gingivalis and may be therapeutically useful supplements for EMD therapy. The source for this answer is PMID: 16332233. </s>

<s>[INST] Do women in Pakistan have a greater burden of clinical cardiovascular risk factors than men? [/INST] yes, Potentially modifiable factors including obesity and saturated fat intake are associated with increased prevalence of CVD risk factors. The high burden of multiple CVD risk factors in women compared to men highlight the need for targeting this vulnerable segment of population in CVD prevention programs in Pakistan, and, possibly neighbouring countries. The source for this answer is PMID: 16337043. </s>

<s>[INST] Does dihydrotestosterone decrease tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells? [/INST] yes, DHT could positively regulate endothelial function through the control of the inflammatory response mediated by nuclear factor-kappaB in endothelial cells. The source for this answer is PMID: 16317058. </s>

<s>[INST] Are polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid? [/INST] yes, There was no association between polymorphisms in genes encoding for acetylsalicylic acid metabolizing enzymes on the prevalence of gastric complaints in cardiovascular patients on acetylsalicylic acid. The source for this answer is PMID: 16305586. </s>

<s>[INST] Does smoking influence aberrant CpG hypermethylation of multiple genes in human prostate carcinoma? [/INST] yes, This is the first study to demonstrate significant correlation of the methylation status of multigenes with smoking status in PC. Smoking status may influence both progression and prognosis of PC through CpG hypermethylation of related genes. The source for this answer is PMID: 16323173. </s>

<s>[INST] Is long-term hormone therapy and radiation cost-effective for patients with locally advanced prostate carcinoma? [/INST] yes, The current analysis showed that LTAD was cost-effective for the entire population studied in RTOG trial 92-02. The source for this answer is PMID: 16323171. </s>

<s>[INST] Does epidermal growth factor reduce hepatic sequelae in experimental necrotizing enterocolitis? [/INST] yes, The results of this study indicate that EGF normalizes cytokine overproduction in the liver of neonatal rats with NEC, which contributes to diminished intestinal damage during the development of experimental NEC. These data suggest that supplementation of formula with EGF can have beneficial effects on the gut/liver axis during NEC pathogenesis. The source for this answer is PMID: 16319449. </s>

<s>[INST] Is flow diversion in transcranial Doppler ultrasound associated with better improvement in patients with acute middle cerebral artery occlusion? [/INST] yes, In patients with persistent MCA occlusions after thrombolytic treatment, arterial blood flow diversion is associated with earlier and better neurological improvement. FD has protective effects on the ischemic brain tissue with persistent MCA occlusion. The source for this answer is PMID: 16330867. </s>

<s>[INST] Does nifekalant hydrochloride suppress severe electrical storm in patients with malignant ventricular tachyarrhythmias? [/INST] yes, Nifekalant hydrochloride is an effective and safe treatment for severe electrical storm. The source for this answer is PMID: 16308500. </s>

<s>[INST] Does leptin replacement therapy modulate circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy? [/INST] yes, These data support existing evidence that leptin has a modest immunomodulatory effect in hypoleptinemic humans. The source for this answer is PMID: 16317060. </s>

<s>[INST] Is in high glucose protein kinase C-zeta activation required for mesangial cell generation of reactive oxygen species? [/INST] yes, In high glucose, mesangial cell PKC-zeta is required for ROS generation from NADPH oxidase similar to PDGF stimulation of PKC-zeta-dependent ROS generation through a pathway independent of PI3 kinase. F-actin disassembly in high glucose also requires ROS. A positive feedback loop occurs between ROS and the activation of PKC-zeta in high glucose. The source for this answer is PMID: 16316329. </s>

<s>[INST] Is tunnel widening after hamstring anterior cruciate ligament reconstruction influenced by the type of graft fixation used : a prospective randomized study? [/INST] yes, There was a significant reduction of TW in both the femur and the tibia using fixation points close to the joint, compared with the system where the distance between the fixation points is long. We conclude that the position of the fixation sites and type of fixation device are major factors in the development of TW after ACL surgery. The source for this answer is PMID: 16325084. </s>

<s>[INST] Is excessive tibial rotation during high-demand activities restored by anterior cruciate ligament reconstruction? [/INST] no, It was concluded that, under high-stress activities, ACL reconstruction may not restore tibial rotation to the previous physiological level, even though anterior tibial translation is restored. Future research on ACL reconstruction should focus on the development of new surgical procedures and/or grafts to address this problem. The source for this answer is PMID: 16325082. </s>

<s>[INST] Is endothelial cell survivin involved in the growth of ovarian endometriotic cysts? [/INST] yes, The diameter of ovarian endometriotic cysts seems to be related to the angiogenic process involving the outer fibrous capsule, and not the inner specialized stroma of ectopic endometrium, since only in the capsule are vessels stimulated to proliferate by VEGF and protected from apoptosis by survivin, and their density is correlated to cyst diameter. The source for this answer is PMID: 16309234. </s>

<s>[INST] Does [ Arresten expressed in vivo suppress the growth of SGC-7901 tumor xenografts in nude mice ]? [/INST] yes, The anti-tumor effect of arresten in the SGC-7901 xenograft is by inhibition of the proliferation of vascular endothelial cell of the tumor. The source for this answer is PMID: 16318776. </s>

<s>[INST] Does cyclosporine-A-mediated inhibition of p-glycoprotein increase methylprednisolone entry into the central nervous system? [/INST] yes, The relatively greater increase in cerebrospinal fluid concentrations of methylprednisolone is consistent with increased penetration of the blood-brain barrier secondary to cyclosporine-mediated p-glycoprotein inhibition. Theoretically, increased methylprednisolone entry into the central nervous system should allow a reduction in the systemic methylprednisolone dose and a consequent decrease in glucocorticoid-mediated side effects. The source for this answer is PMID: 16331311. </s>

<s>[INST] Do verbal intrusions precede memory decline in adults with Down syndrome? [/INST] yes, The production of intrusion errors during a verbal WM task is a characteristic of middle-aged adults with DS. This suggests compromised executive function and control of inhibition within the verbal modality for this group. Further, verbal intrusions are a qualitative aspect of verbal processing that merit attention in considering the issue of deficiencies of language and verbal WM abilities among people with DS. Last, and perhaps most importantly, although not definitive diagnostically, an increase in verbal intrusions is a potentially noteworthy signal when evaluating the cognitive health of adults with DS. The source for this answer is PMID: 16316425. </s>

<s>[INST] Is exercise hyperventilation in chronic heart failure caused by systemic lactic acidosis? [/INST] no, In heart failure VE/VCO(2) slope and low arterial pCO(2) at peak exercise are not related to the degree of systemic lactic acidosis. Lactic acidosis is therefore not a plausible mechanism of exercise induced hyperventilation. The source for this answer is PMID: 16326362. </s>

<s>[INST] Does procalcitonin do discriminate between sepsis and systemic inflammatory response syndrome? [/INST] yes, PCT is able to differentiate between SIRS and sepsis while CRP is not. Moreover, unlike CRP, PCT concentrations varied with the evolution of sepsis. The source for this answer is PMID: 16326799. </s>

<s>[INST] Do mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy? [/INST] yes, Cardiac chaperone dysfunction acutely leads to altered cardiomyocyte mechanics, perturbations in mitochondrial-sarcomere architecture, and deficits in mitochondrial function, which can result in activation of apoptosis and heart failure. The source for this answer is PMID: 16316967. </s>

<s>[INST] Does [ correlate of problem drinking by the alcohol use disorders identification test on Korean college campus ]? [/INST] yes, College students' with an Alcohol Use Disorder is a very severe and large problem within colleges. An Alcohol Use Disorder is determined by individual and family variables, the college environmental and life variables, as well as behavior variables. The source for this answer is PMID: 16323631. </s>

<s>[INST] Does fetal gender affect maternal serum total and placental alkaline phosphatase levels during pregnancy? [/INST] yes, Fetal gender seems to affect total and placental ALP levels in healthy pregnant women, particularly during the second and third trimester of pregnancy. Higher ALP levels in pregnant women with female fetuses than in those with male fetuses may suggest that knowledge of the fetal gender may be in particular importance for the studies using ALP as a marker for the prediction of variety of diseases and complications seen during pregnancy. The source for this answer is PMID: 16332408. </s>

<s>[INST] Does glycodelin reduce carcinoma-associated gene expression in endometrial adenocarcinoma cells? [/INST] yes, Reduction by glycodelin transfection of carcinoma cell proliferation and expression of MUC1 and Bcl-XL is significant because these genes are often overexpressed in human cancers--MUC1 is linked to invasive growth and metastases, and both confer resistance to chemotherapy. These results suggest a novel mechanism whereby malignant growth of endometrial adenocarcinoma cells is regulated. The source for this answer is PMID: 16325596. </s>

<s>[INST] Does impact of a fall menu-driven incident-reporting system on documentation and quality improvement in nursing homes? [/INST] yes, The MDIRS can have a significant impact in improving how nursing staff assess residents following a fall incident. Traditional narrative methods of documenting adverse incidents are time consuming and may not yield sufficient and accurate data. This model has the potential to enhance quality-improvement efforts and augment the current system of adverse incident reporting in nursing homes. The source for this answer is PMID: 16326667. </s>

<s>[INST] Is cognitive function minimally impaired after ambulatory surgery? [/INST] yes, A statistically significant impairment of cognitive function in the three days following GA, but not LA was found. However, the magnitude of this impairment was small, and is of doubtful clinical significance. Modern ambulatory anesthesia may cause less delayed cognitive impairment than was previously thought. The source for this answer is PMID: 16326669. </s>

<s>[INST] Does diazoxide attenuate insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats? [/INST] yes, Suppression of hyperinsulinemia by DZ enhanced hepatic insulin sensitivity and decreased expression of key genes regulating hepatic lipogenesis without altering genes regulating lipid oxidation; implying that attenuation of hyperinsulinemic state by DZ enhances metabolic efficiency of insulin and is therapeutically beneficial. The source for this answer is PMID: 16319780. </s>

<s>[INST] Does selection bias influence reported contralateral breast cancer incidence and survival in high risk non-BRCA1/2 patients? [/INST] yes, Overall survival and contralateral breast cancer incidence were similar in 'unselected' non-BRCA1/2- and sporadic patients. Reports of higher CBC incidence and better survival in non-BRCA1/2 patients may substantially be caused by DNA testing selection-bias. The source for this answer is PMID: 16319990. </s>

<s>[INST] Are early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy predictive for radiation pneumonitis? [/INST] yes, Early variations of circulating IL-6 and IL-10 levels during 3D-CRT are significantly associated with the risk of radiation pneumonitis. Variations of circulating IL-6 and IL-10 levels during 3D-CRT may serve as independent predictive factors for this complication. The source for this answer is PMID: 16314635. </s>

<s>[INST] Does the peroxisomal multifunctional protein interact with cortical microtubules in plant cells? [/INST] yes, Plant MFP is associated with the cortical microtubule array, in addition to its expected localization in the peroxisome. This observation, coupled with apparent interactions that frequently occur between microtubules and peroxisomes in the cell cortex, supports the hypothesis that MFP is concentrated on microtubules in order to facilitate the regulated import of MFP into peroxisomes. The source for this answer is PMID: 16313672. </s>

<s>[INST] Is fGF receptor phosphotyrosine 766 a target for Grb14 to inhibit MDA-MB-231 human breast cancer cell signaling? [/INST] yes, Grb14 binds to the Y766 site of MDA-MB-231-FGFR, competing for PLCy activation, thus inducing an arrest of the signaling transduction cascades. The source for this answer is PMID: 16309174. </s>

<s>[INST] Is reporting of mortality in a psoriatic arthritis clinic primarily a function of the number of clinic contacts and not disease severity? [/INST] yes, It is recommended that research databases routinely record the time between death and reporting of death and the method of ascertaining and reporting death. More detailed information on the scheduling of clinic visits may also be helpful. The source for this answer is PMID: 16331765. </s>

<s>[INST] Is in the era of nephelometry , latex agglutination still good enough to detect rheumatoid factor? [/INST] yes, In routine practice, and particularly in developing countries such as India, LAT can still be the preferred method for RF determination. The source for this answer is PMID: 16331760. </s>

<s>[INST] Does prior anti-dsDNA antibody status predict later disease manifestations in systemic lupus erythematosus? [/INST] no, The past presence of anti-dsDNA Ab identified patients with an increased risk of subsequent renal flares. However, as a new onset of anti-dsDNA Abs occurred late in the disease course, prior anti-dsDNA status was not adequate to predict disease flares. The source for this answer is PMID: 16328091. </s>

<s>[INST] Does linezolid diminish inflammatory cytokine production from human peripheral blood mononuclear cells? [/INST] yes, These data indicate that antibacterial agents may modify acute phase inflammatory response through their effects on cytokines synthesis by monocytes. The source for this answer is PMID: 16314183. </s>

<s>[INST] Does chemically modified heparin inhibit the in vitro adhesion of nonsmall cell lung cancer cells to P-selectin? [/INST] yes, These findings suggest that some chemically modified heparins with low anticoagulant activity may deserve further testing in the experimental NSCLC treatment protocols. The source for this answer is PMID: 16331491. </s>

<s>[INST] Is surface expression and cytolytic function of natural killer cell receptors altered in chronic hepatitis C? [/INST] yes, The present study indicates that defective expression of NKR represents a novel mechanism contributing to impaired function of NK cells and CD8+ T cells in chronic hepatitis C. The source for this answer is PMID: 16322112. </s>

<s>[INST] Does sulfasalazine reduce bile acid induced apoptosis in human hepatoma cells and perfused rat livers? [/INST] yes, Sulfasalazine is a potent inhibitor of GCDCA induced hepatocyte apoptosis in vitro and in the intact liver. The source for this answer is PMID: 16322111. </s>

<s>[INST] Does arginine vasopressin alter mucosal tissue oxygen tension and oxygen supply in an acute endotoxemic pig model? [/INST] no, AVP administration did not further compromise mucosal tissue oxygen tension and oxygen supply in the acute phase of endotoxic pigs. The source for this answer is PMID: 16328220. </s>

<s>[INST] Is inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells? [/INST] no, Our results show that inhibition of PI3K/PKB signaling by indole-3-carbinol or LY294002 is not directly correlated with induction of apoptosis in several breast or prostate cell lines. The source for this answer is PMID: 16322316. </s>

<s>[INST] Does the variable number of tandem repeats element in DAT1 regulate in vitro dopamine transporter density? [/INST] yes, This study identified the DAT1 VNTR as a functional polymorphism and provides an interpretive framework for its association with behavioral phenotypes. The source for this answer is PMID: 16309561. </s>

<s>[INST] Does insufficient ability of omental milky spots to prevent peritoneal tumor outgrowth support omentectomy in minimal residual disease? [/INST] yes, Since the ability of omental milky spots is, even in MRD, insufficient to prevent intra abdominal tumor outgrowth, omentectomy, which reduces tumor load, is recommended in surgical treatment of intra abdominal tumors that are prone to disseminate intraperitoneally. The source for this answer is PMID: 16311732. </s>

<s>[INST] Is a variant of the sigma receptor type-1 gene a protective factor for Alzheimer disease? [/INST] yes, The present study suggests that the TT-241-240P2 haplotype of the SIGMAR1 gene, which decreases expression of the gene, may have a protective role against susceptibility to AD. The source for this answer is PMID: 16319298. </s>

<s>[INST] Does gene expression profiling predict survival in conventional renal cell carcinoma? [/INST] yes, cRCC displays molecular heterogeneity and can be separated into gene expression subgroups that correlate with survival after surgery. We have identified a set of 259 genes that predict survival after surgery independent of clinical prognostic factors. The source for this answer is PMID: 16318415. </s>

<s>[INST] Do polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease? [/INST] yes, Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. These results could probably, at least partly, explain the favorable effects of red wine on the cardiovascular system. The source for this answer is PMID: 16319551. </s>

<s>[INST] Do preoperative cerebral ischemic lesions predict physical health status after on-pump coronary artery bypass surgery? [/INST] yes, This study strongly suggests that the combination of preoperative cerebral ischemic injury and use of cardiopulmonary bypass can predict postoperative health status at 3 months. Cerebral magnetic resonance imaging might be a more specific indicator than age for preoperative assessment of vulnerability or resilience during rehabilitation after on-pump cardiac surgery. The source for this answer is PMID: 16308017. </s>

<s>[INST] Is salty taste acceptance by infants and young children related to birth weight : longitudinal analysis of infants within the normal birth weight range? [/INST] yes, Measures related to salty taste preference were inversely related to birth weight over the first 4 years of life. Additional studies should substantiate these findings and explore whether early response to salty taste predicts future sodium intake, blood pressure, or other public health-related outcomes. The source for this answer is PMID: 16306932. </s>

<s>[INST] Is peritoneal fast transport in incident peritoneal dialysis patients consistently associated with systemic inflammation? [/INST] no, Initial fast transport was not associated with systemic inflammation and atherosclerosis. In a population with preserved RRF and absence of baseline serious co-morbidity, it was not predictive of worse prognosis. Other determinants of early peritoneal fast transport deserve investigation. The source for this answer is PMID: 16332703. </s>

<s>[INST] Are wyoming physicians significant providers of safety net care? [/INST] yes, Wyoming family and general practice physicians provide significant amounts of informal safety net care, which is threatened by income loss. Thoughtful public policy is needed to ensure that vulnerable rural Americans have access to care that is not tied to the financial well being of their health care providers. The source for this answer is PMID: 16322411. </s>

<s>[INST] Does matching procedure to morphology improve outcomes in neonates with tricuspid atresia? [/INST] yes, Smaller shunt size and decreased pulmonary blood flow decrease mortality after initial palliation and increase the rate of successful transition to cavopulmonary anastomosis. Outcomes can be improved by placing smaller shunts from the innominate artery, especially in patients with any mitral regurgitation. The source for this answer is PMID: 16307990. </s>

<s>[INST] Are arthritis in mice that deficient in interleukin-1 receptor antagonist is dependent on genetic background? [/INST] yes, These data indicate that the spontaneous arthritis of IL-1Ra deficiency is highly dependent on non-major histocompatibility complex genes and that autoimmunity to CII is not the major disease-inducing event. Class II immune response genes are more important for the regulation of CIA, and although these 2 models of arthritis share many pathogenic mechanisms, they also have significant differences. The source for this answer is PMID: 16320323. </s>

<s>[INST] Is ratio of mRNA expression of progesterone receptor isoforms AB to B in human oviduct mucosal cells during the ovulatory cycle? [/INST] yes, We found an increase in the relative abundance of the progesterone receptor B isoform in the ampullary region which is the site of fertilization and early embryo cleavage. Our results indicate that progesterone responsive genes are more likely to be activated in the ampullary region of the oviduct due to the difference in PRAB to PRB ratio. Providing support for the hypothesis that progesterone may play a specific role in providing an appropriate environment for sperm capacitation, fertilization and early embryo cleavage. The source for this answer is PMID: 16331541. </s>

<s>[INST] Are fish consumption in pregnancy and omega-3 status after birth associated with postnatal depression? [/INST] no, Prenatal fish consumption was measured using only a food frequency questionnaire, and no participants consumed oily fish (rich in omega-3s) regularly. The source for this answer is PMID: 16325262. </s>

<s>[INST] Is aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery associated with increased postoperative drainage loss? [/INST] yes, Aspirin and clopidogrel up to 2 days prior to CABG were associated with a significantly higher postoperative drainage loss. The source for this answer is PMID: 16311970. </s>

<s>[INST] Does novel oncolytic adenovirus selectively target tumor-associated polo-like kinase 1 and tumor cell viability? [/INST] yes, Coupling plk1 targeting with oncolysis had shown superior antitumor efficacy. Present findings would benefit the development of novel oncolytic adenoviruses generally applicable to a wide range of molecule-based therapeutics. The source for this answer is PMID: 16322306. </s>

<s>[INST] Is high thioredoxin expression associated with resistance to docetaxel in primary breast cancer? [/INST] yes, High thioredoxin expression in prechemotherapy tumor samples, but not the increase in thioredoxin expression induced by docetaxel, is associated with resistance to docetaxel in breast cancer. Thioredoxin and ER might be clinically useful in the prediction of a response to docetaxel. The source for this answer is PMID: 16322305. </s>

<s>[INST] Does phosphatidylinositol-3-kinase signaling mediate vascular smooth muscle cell expression of periostin in vivo and in vitro? [/INST] yes, Upregulation of periostin expression in rat carotid arteries following balloon injury and in cultured VSMCs after stimulation by growth factors is mediated through PI-3-kinase-dependent signaling pathway. Periostin protein secreted by VSMCs plays a significant role in regulating VSMC migration in vitro. The source for this answer is PMID: 16325820. </s>

<s>[INST] Is cardiac rehabilitation associated with an improvement in C-reactive protein levels in both men and women with cardiovascular disease? [/INST] yes, Participation in CR was associated with a marked improvement of cardiac risk factors and appears to independently decrease the level of CRP regardless of gender, age, or presence of metabolic syndrome. The source for this answer is PMID: 16327525. </s>

<s>[INST] Does visual feedback attenuate force fluctuations induced by a stressor? [/INST] yes, Removal of visual feedback increased the force fluctuations and decreased information transmission during a stressor period, which suggests that integration of visual feedback can attenuate the stressor-induced enhancement of synaptic input received by the motor neuron pool. The source for this answer is PMID: 16331140. </s>

<s>[INST] Does elevation of hyaluronidase-1 and soluble intercellular adhesion molecule-1 help select bladder cancer patients at risk of invasion? [/INST] yes, Serial monitoring of sICAM-1 (in urine and/or serum) is potentially recommended for selecting patients who are at risk of tumor invasion. The source for this answer is PMID: 16314195. </s>

<s>[INST] Is genetic polymorphisms G894T on the eNOS gene associated with endothelial function and vWF levels in premature myocardial infarction survivors? [/INST] yes, The presence of 894T allele on eNOS gene is associated with impaired endothelial function and higher levels of von Willebrand factor in relatively young patients with myocardial infarction. This finding implies that genetic polymorphism G894T on eNOS may affect endothelial function in patients with a history of premature myocardial infarction. The source for this answer is PMID: 16337503. </s>

<s>[INST] Does increase in serum troponin-I following rotational atherectomy reliably predict the occurrence of reversible wall motion abnormalities? [/INST] yes, Our results suggest that RA can cause substantial deterioration in left ventricular wall motion. Serum troponin-I, a sensitive indicator of myocardial damage, may be useful in predicting reversible LV wall motion abnormalities following RA. The source for this answer is PMID: 16337502. </s>

<s>[INST] Is endurance sports a risk factor for atrial fibrillation after ablation for atrial flutter? [/INST] yes, A history of endurance sports activity is associated with the development of AF after ablation of atrial flutter. The source for this answer is PMID: 16337500. </s>

<s>[INST] Is [ Meridian regulation a course of communicating and implicating of the informational system with the material system ]? [/INST] yes, The regulating mechanism of meridians has two levels. The macroscopic regulation center is the brain, and the microscopic regulation base is the energy and informational current that depends on electromagnetic and chemical oscillation mainly. The meridian regulation is the process of the energy and informational system communicating and implicating with the material system. Neuroendocrine is the link of communicating and implicating, and Ca2+ oscillation frequencies exert intermediary function between the two systems. The source for this answer is PMID: 16312929. </s>

<s>[INST] Is warfarin induction at 5 mg daily safe with a low risk of anticoagulant overdose : results of an audit of patients with deep vein thrombosis commencing warfarin? [/INST] yes, The low-dose protocol with infrequent testing is safe and convenient for outpatient management. However, our results suggest that patients on this protocol take between 6-10 days to achieve a stable INR. The source for this answer is PMID: 16313547. </s>

<s>[INST] Does intensive care unit extubation preclude extrarenal organ recovery from donors after cardiac death? [/INST] no, ICU extubation should not eliminate extrarenal organs from consideration and may be preferable to OR extubation by improving family support and eliminating OR staff concerns about their role in end-of-life care. The source for this answer is PMID: 16314792. </s>

<s>[INST] Is high dosage treatment of nitrogen-containing bisphosphonate ibandronate required for osseointegration of cementless metal implants? [/INST] yes, The results of the present study indicate that improved osseointegration of hydroxyapatite-coated and uncoated titanium implants is dose-dependent and requires high-dose application of bisphosphonate ibandronate equivalent to that needed to treat patients with tumor disease. Lower doses equivalent to those for treatment of osteoporosis showed no beneficial effect. The source for this answer is PMID: 16307188. </s>

<s>[INST] Do the apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men? [/INST] yes, The apoB/AI ratio was related to the metabolic syndrome, as well as to a direct measurement of insulin resistance. Despite this, the apoB/AI ratio and the metabolic syndrome were both independent long-term predictors of MI in a community-based sample of middle-aged men. The source for this answer is PMID: 16306426. </s>

<s>[INST] Does the suppression of spinal F-waves by propofol predict immobility to painful stimuli in humans? [/INST] no, F-waves are almost completely suppressed at subclinical propofol concentrations and they are therefore not suitable for prediction of motor responses to noxious stimuli under propofol mono-anaesthesia. The source for this answer is PMID: 16317030. </s>

<s>[INST] Are trends in disease modifying antirheumatic drug prescription in early rheumatoid arthritis influenced more by hospital setting than patient or disease characteristics? [/INST] yes, Temporal trends in DMARD prescription indicate an increasingly aggressive approach to disease management among Swedish rheumatologists. However, the association of hospital type with DMARD prescription suggests that the adoption of research findings in clinical care varies considerably. The source for this answer is PMID: 16322085. </s>

<s>[INST] Does the effect of lubricant eye drop on ocular wavefront aberrations? [/INST] yes, Ocular wavefront aberrations may change following eye drop instillation as measured objectively by the WaveScan system. This effect should be taken into consideration in the assessment of patients for wavefront-guided laser vision correction procedures. The source for this answer is PMID: 16329363. </s>