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<s>[INST] Is urinary albumin excretion rate correlated with severity of coronary artery disease in elderly type 2 diabetic patients? [/INST] yes, The occurrence of coronary heart disease in elderly type 2 diabetes mellitus patients with microalbuminuria was higher than that in patients with normal albuminuria, and the severity of the disease also increased in patients with microalbuminuria. In elderly type 2 diabetes mellitus patients, urinary albumin excretion rate was positively correlated with the incidence and severity of coronary heart disease and was also an independent factor contributing to coronary heart disease. The source for this answer is PMID: 23217383. </s> |
<s>[INST] Does connexin45 regulate endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype? [/INST] yes, These studies reveal a critical role for Cx45 in the regulation of endothelial-induced mural cell differentiation, which is consistent with the phenotype of Cx45-deficient embryos that exhibit dysregulated transforming growth factor-β and lack mural cell development. The source for this answer is PMID: 23220276. </s> |
<s>[INST] Is serum uric acid level an independent risk factor for presence of calcium in coronary arteries : an observational case-controlled study? [/INST] yes, Serum uric acid level is an independent risk factor for presence of coronary calcium. Moreover, increasing levels of serum uric acid are associated with increasing CACS. The source for this answer is PMID: 23228977. </s> |
<s>[INST] Is bile salt export pump dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma? [/INST] yes, BSEP expression is severely diminished in HCC patients associated with alteration of FXR isoform expression induced by inflammation. Restoration of BSEP expression through suppressing inflammation in the liver may reestablish bile acid homeostasis. The source for this answer is PMID: 23213087. </s> |
<s>[INST] Is vitamin A deficiency associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy? [/INST] yes, A high percentage of patients with chronic HCV infection have serum vitamin A deficiency. This condition is associated with nonresponse to antiviral therapy. The source for this answer is PMID: 23213086. </s> |
<s>[INST] Is the safety of a `` fast-track '' program after laparoscopic colorectal surgery comparable in older patients as in younger patients? [/INST] yes, Fast-track after laparoscopic colorectal surgery can be safely applied in carefully selected elderly patients older than age 70 years. Physicians should keep in mind complications that may present after discharge and should actively educate patients about them. The source for this answer is PMID: 23232990. </s> |
<s>[INST] Do deposit-feeding sea cucumbers enhance mineralization and nutrient cycling in organically-enriched coastal sediments? [/INST] yes, Our study demonstrates the functional role and potential of sea cucumbers to ameliorate some of the adverse effects of organic matter enrichment in coastal ecosystems. The source for this answer is PMID: 23209636. </s> |
<s>[INST] Does the flavonoid isoquercitrin promote neurite elongation by reducing RhoA activity? [/INST] yes, As several members of the Rho GTPase family are implicated in human neurological disorders/injuries, our results suggest that isoquercitrin could be used in the treatment of these pathological states through its effect on this family of molecular switches. The source for this answer is PMID: 23209630. </s> |
<s>[INST] Do decisions for others become less impulsive the further away they are on the family tree? [/INST] yes, The observed discount functions were steeper (i.e. more impulsive) for choices in which the decision-maker was the beneficiary than for all other beneficiaries. Impulsiveness of decisions declined systematically with the distance of the beneficiary from the decision-maker. The data are discussed with reference to the implusivity and interpersonal empathy gaps in decision-making. The source for this answer is PMID: 23209580. </s> |
<s>[INST] Are plasma vitamin D and parathormone associated with obesity and atherogenic dyslipidemia : a cross-sectional study? [/INST] yes, BMI was the variable most strongly associated with plasma 25(OH)D and PTH concentrations in our study. Low 25(OH)D and high PTH concentrations were not independently associated with an increased risk of MetS, or diabetes. Our data support a possible contribution of plasma 25(OH)D to the pathogenesis of hypertriglyceridemia and AD through inflammation. The source for this answer is PMID: 23228198. </s> |
<s>[INST] Is survivin expression associated with lens epithelial cell proliferation and fiber cell differentiation? [/INST] yes, Survivin is expressed during chick and mouse lens development and in chick lens epithelial cell cultures. High levels of Survivin expression correlated with high rates of proliferation of lens epithelial cells at early stages of development. Downregulation of Survivin expression with development and its progressive localization to the nuclei of lens fiber cells was coincident with a decrease in cell proliferation and increased denucleation in differentiating lens fiber cells. These studies suggest an important role for Survivin as a dual regulator of lens epithelial cell proliferation and lens fiber cell differentiation. The source for this answer is PMID: 23213276. </s> |
<s>[INST] Is nectin-1-specific entry of herpes simplex virus 1 sufficient for infection of the cornea and viral spread to the trigeminal ganglia? [/INST] yes, Our findings suggest that nectin-1 alone is sufficient for HSV-1 entry into the cornea and spread to the TG. The source for this answer is PMID: 23213272. </s> |
<s>[INST] Do human mesenchymal stem cells reduce lung injury in immunocompromised mice but not in immunocompetent mice? [/INST] yes, The application of hMSC for the treatment of acute and chronic lung injury is significantly affected by the immune status of the recipient. Lack of hMSC-mediated repair observed in C57Bl/6 mice was likely to be due to limitations of their immune privilege and differential priming of hMSC in immunocompetent versus immunocompromised hosts. The source for this answer is PMID: 23207668. </s> |
<s>[INST] Is reliability of adenoma detection rate based on procedural volume? [/INST] yes, Clinical examples come from small numbers of physicians and patients. The source for this answer is PMID: 23211748. </s> |
<s>[INST] Is the Val158Met polymorphism of the COMT gene associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery? [/INST] yes, Our results show that the COMT Val158Met polymorphism contributes to variability in pain sensitivity after cardiac surgery of morphine-treated patients in the intensive care unit, because Met-allele carriers were more sensitive to overall pain and procedure-related pain. The source for this answer is PMID: 23210659. </s> |
<s>[INST] Do staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults? [/INST] yes, We conclude that the neonatal complement system exhibits a maturational deficiency. This may reduce the ability of neonates to combat biofilm-associated SE infections. The source for this answer is PMID: 23232670. </s> |
<s>[INST] Is red cell distribution width associated with acute myocardial infarction in young patients? [/INST] yes, High levels of RDW were associated with STEMI in young patients. We think that RDW is a widely available marker with no additional costs, in contrast to other novel markers of cardiovascular risk. The source for this answer is PMID: 23224922. </s> |
<s>[INST] Is the increase of serum chemerin concentration mainly associated with the increase of body mass index in obese , non-diabetic subjects? [/INST] yes, The results presented here indicate that serum chemerin concentrations correlated with BMI, whereas chemerin mRNA levels in adipose tissue did not. Thus the elevated circulating chemerin concentration in obese, non-diabetic patients was mainly associated with the increased BMI. The source for this answer is PMID: 23211604. </s> |
<s>[INST] Is serum glycated albumin inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance? [/INST] yes, Serum GA was inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance. The source for this answer is PMID: 23209844. </s> |
<s>[INST] Do platelet P2Y₁₂ blockers confer direct postconditioning-like protection in reperfused rabbit hearts? [/INST] yes, Clopidogrel and cangrelor protected rabbit hearts against infarction. The mechanism appears to involve signal transduction during reperfusion rather than inhibition of intravascular coagulation. We hypothesize that both drugs protect by activating IPOC's protective signaling to prevent reperfusion injury. If true, patients receiving P2Y₁₂ inhibitors before percutaneous intervention may already be postconditioned thus explaining failure of recent clinical trials of postconditioning drugs. The source for this answer is PMID: 23233653. </s> |
<s>[INST] Are atypical depression and alcohol misuse related to the cardiovascular risk in the general population? [/INST] yes, To conclude results emphasize the need to subtype depression and to pay particular attention to the atypical subtype. Comorbid alcohol misuse may further increase the cardiovascular risk. Efforts to diminish smoking in subjects with mental disorders could be crucial measures to reduce their high incidence of cardiovascular disease. The source for this answer is PMID: 23216242. </s> |
<s>[INST] Is quality of interaction between at-risk infants and caregiver at 12-15 months associated with 3-year autism outcome? [/INST] yes, This is the first prospective evidence that early dyadic interaction between at-risk infants and their parents is associated with later diagnostic outcome in ASD. Possible explanations for these findings and their theoretical implications are considered. The source for this answer is PMID: 23227853. </s> |
<s>[INST] Does muscarinic receptor M3 mediate human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase? [/INST] yes, These results suggest a major role of M(3) muscarinic receptors mediating the human gallbladder contraction through voltage-gated Ca(2+) channels and Rho kinase. M(3)-selective muscarinic receptor antagonists could be of therapeutic importance in the treatment of biliary motility disorders. The source for this answer is PMID: 23227858. </s> |
<s>[INST] Do outcome of a randomized study of a mental health peer education and support group in the VA? [/INST] yes, This study adds to the evidence suggesting no short-term incremental benefit (or harm) from peer services beyond usual care. The source for this answer is PMID: 23203360. </s> |
<s>[INST] Does prolonged prothrombin time correlate with serum monoclonal protein concentration in patients with plasma cell dyscrasia? [/INST] yes, An association between disease severity and prolonged PT is suggested by our finding that patients with multiple myeloma were more likely to have prolonged PT than patients with other plasma cell neoplasms. Of the factors examined, the monoclonal protein level was significantly higher in patients with isolated prolonged PT and correlated with PT. The source for this answer is PMID: 23217011. </s> |
<s>[INST] Does pre-operative gastric emptying time correlate with clinical response to gastric electrical stimulation in the treatment of gastroparesis? [/INST] yes, GES significantly improves symptoms of gastroparesis on the GCSI score. Not all patients respond equally to GES, and response may be predicted by pre-operative solid gastric emptying times. The source for this answer is PMID: 23206591. </s> |
<s>[INST] Are mRI findings often missed in the diagnosis of Creutzfeldt-Jakob disease? [/INST] yes, CJD-associated MRI changes are often not documented on the formal investigation report at the referring centre. This is important as delay makes enrolment to clinical trials futile because of highly advanced disease. If a diagnosis of CJD is suspected, even if the initial imaging is reported as normal, a specialist MRI review either by an experienced neuroradiologist or by a prion disease specialist unit could facilitate earlier diagnosis. The source for this answer is PMID: 23216655. </s> |
<s>[INST] Does [ Evaluation of effectiveness of several repellents against mosquito bite available at the Polish market ]? [/INST] yes, Both kinds of product can give effective protection against mosquito bites. Their use is most effective, cheaper and more safe for the environment method of protection against mosquitoes than chemical spraying of large areas. The source for this answer is PMID: 23230720. </s> |
<s>[INST] Do brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain? [/INST] yes, The results provide evidence that Aβ1-40 acts on distinct luminal and abluminal vascular targets, the deleterious cerebrovascular effects of which are additive. Furthermore, the findings highlight the importance of circulating Aβ1-40 in the cerebrovascular dysfunction and may provide insight into the cerebrovascular alterations in conditions in which elevations in plasma Aβ1-40 occur. The source for this answer is PMID: 23204056. </s> |
<s>[INST] Does an automated approach for the identification of horizontal gene transfers from complete genomes reveal the rhizome of Rickettsiales? [/INST] yes, Our analysis provides a comprehensive, systematic approach for the automated detection of HGTs from several complete proteome sequences that can be applied to detect instances of HGT within other genomes of interest. The source for this answer is PMID: 23234643. </s> |
<s>[INST] Does citrullination enhance the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts? [/INST] yes, Our results suggest that fibrin mediates inflammatory responses in RASF via a TLR4 pathway. In this way, fibrin and particularly its citrullinated form may contribute to sustain the cytokine burst in RA. The source for this answer is PMID: 23234648. </s> |
<s>[INST] Is eUS finding of geographic hyperechoic area an early predictor for severe acute pancreatitis? [/INST] yes, Typical EUS features of AP are a heterogenous hypoechoic parenchymal changes with peripancreatic fluid collection. The novel EUS variable of GHA in the early phase of AP seems to have prognostic value and could be correlated with a worse clinical outcome. The source for this answer is PMID: 23217287. </s> |
<s>[INST] Are plasma miR-17-5p , miR-20a and miR-22 down-regulated in women with endometriosis? [/INST] yes, Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis compared with those without endometriosis in mainland China. The source for this answer is PMID: 23203215. </s> |
<s>[INST] Do effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption? [/INST] yes, These findings suggest that common polymorphisms in FMO3 influence nicotine clearance and that these genetic variants in turn influence cigarette consumption. The source for this answer is PMID: 23211429. </s> |
<s>[INST] Does chlamydia sentinel surveillance in Aboriginal Community Controlled Health Services found higher testing and positivity rates among younger people? [/INST] yes, Chlamydia testing at these ACCHSs approached recommended levels among some patient groups, however, it should increase. High positivity among younger people highlights they should be targeted. The source for this answer is PMID: 23216501. </s> |
<s>[INST] Are implicit and explicit drug-related cognitions during detoxification treatment associated with drug relapse : an ecological momentary assessment study? [/INST] yes, Drug-related cognitive processes assessed with ecological momentary assessments were associated with relapse during drug detoxification. Real-time assessment of craving and cognitions may help to identify which individuals are at risk of relapse and when they are at risk of relapse. The source for this answer is PMID: 23231572. </s> |
<s>[INST] Does proximal junctional kyphosis result in inferior SRS pain subscores in adult deformity patients? [/INST] yes, PJK results in worse clinical outcomes measured by the SRS Pain subscore. Our regression model suggests that pain in the upper back has a strong predictive value for PJK. The source for this answer is PMID: 23232215. </s> |
<s>[INST] Does one size fit all : differences in newborn weight among mothers of Philippine and other East Asian origin? [/INST] no, Infants of mothers born in the Philippines weigh significantly less than those of Canadian-born women or mothers emigrating from other East Asian countries. Those who use birth weight curves should consider these differences. The source for this answer is PMID: 23231840. </s> |
<s>[INST] Is n-WASP highly expressed in hepatocellular carcinoma and associated with poor prognosis? [/INST] yes, These data establish that N-WASP is highly expressed in HCC and its strong prognostic importance. Therefore, the gene/protein might serve as a potential therapeutic target for HCC. The source for this answer is PMID: 23218879. </s> |
<s>[INST] Does hawthorn leave flavonoids decreases inflammation related to acute myocardial ischemia/reperfusion in anesthetized dogs? [/INST] yes, HLF could improve the situation of acute myocardial ischemia and inhibit the inflammation in anesthetized dogs, which might be due to its increasing effect on the GRK2 and NF-κB expressions. The source for this answer is PMID: 23212573. </s> |
<s>[INST] Does [ Klotho gene attenuate the progression of hypertension and heart damage in spontaneous hypertensive rats ]? [/INST] yes, The Klotho gene can attenuate the progression of hypertension and abolishes myocardial hypertrophy and myocardial fibrosis. The protective effect observed in the rAAV.mKL group of SHRs may be attributed to increased Klotho protein and suppression of insulin and IGF-1 signaling pathways through inhibition of Akt phosphorylation. The source for this answer is PMID: 23225045. </s> |
<s>[INST] Does lINE-1 methylation show little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer? [/INST] yes, LINE-1 methylation shows little intra-patient tumor heterogeneity, indicating the suitability of its use for molecular diagnosis in CRC. The methylation is relatively stable during CRC progression, leading us to propose a new concept for the association between LINE-1 methylation and disease stage. The source for this answer is PMID: 23216958. </s> |
<s>[INST] Are serum peptides , represented by complement 3f des-arginine , useful for prediction of the response to pegylated interferon-α plus ribavirin in patients with chronic hepatitis C? [/INST] yes, Serum peptides, especially C3f-dR, would be useful predictors for SVR to PEG IFN-α/RBV. The complements may be involved in the HCV elimination. The source for this answer is PMID: 23216931. </s> |
<s>[INST] Does overexpression of CD9 in human breast cancer cells promote the development of bone metastases? [/INST] yes, Our study reveals a potential implication of CD9 in the formation of bony metastases from breast cancer cells. The source for this answer is PMID: 23225418. </s> |
<s>[INST] Do ultrasound imagery for dental implant diagnosis and treatment planning in a porcine model? [/INST] yes, A 2-D sector scanning ultrasound system was demonstrated to be capable of imaging representative features for implant treatment planning in a porcine model; these included implants placed in edentulous ridges; implants placed for single tooth replacement; implants with simulated dehiscences; teeth with simulated dehiscences; and mental foramina. Specific acoustic signatures for these features were defined. Qualitative differences between ultrasound and other dental imaging techniques were described. The source for this answer is PMID: 23217466. </s> |
<s>[INST] Is the CLOCK C3111T polymorphism associated with reward dependence in healthy Japanese subjects? [/INST] yes, Our findings suggest that the CLOCK C3111T polymorphism may affect personality traits in healthy Japanese subjects. The source for this answer is PMID: 23221812. </s> |
<s>[INST] Do first-year residents outperform third-year residents after simulation-based education in critical care medicine? [/INST] yes, First-year residents who completed a simulation-based educational intervention demonstrated higher clinical competency compared with third-year residents who did not undergo simulation training. Critical care competency cannot be assumed after clinical intensive care unit rotations; simulation-based curricula can help ensure residents are proficient to care for critically ill patients. The source for this answer is PMID: 23222546. </s> |
<s>[INST] Does overexpression of CDKN1B inhibit fibroblast proliferation in a rabbit model of experimental glaucoma filtration surgery? [/INST] yes, The persistent overexpression of CDKN1B mediated by the recombinant adenovector expressing exogenous CDKN1B in Tenon's fibroblasts after GFS may lead to the inhibition of fibroblast proliferation and the downregulation of Cdk2 and Cdk4 activity, thereby reducing the severity of scar formation and the surgical outcome. The source for this answer is PMID: 23233251. </s> |
<s>[INST] Does tissue kallikrein attenuate choroidal neovascularization via cleavage of vascular endothelial growth factor? [/INST] yes, The current data indicate that kallikrein exhibits antiangiogenic properties by cleaving VEGF(164) in a laser-induced CNV model. The source for this answer is PMID: 23233257. </s> |
<s>[INST] Is quantitation of hematogones at the time of engraftment a useful prognostic indicator in allogeneic hematopoietic stem cell transplantation? [/INST] yes, Quantitation of hematogones at engraftment is useful to predict prognosis of patients treated with allogeneic stem cell transplantation. The source for this answer is PMID: 23233661. </s> |
<s>[INST] Does lumbar multifidus muscle thickness predict patients with low back pain who improve with trunk stabilization exercises? [/INST] no, LM-muscle activation does not appear to be a clinical feature that predicts patients with LBP likely to benefit from STB exercises. The source for this answer is PMID: 23228626. </s> |
<s>[INST] Does microRNA profiling in lung cancer reveal new molecular markers for diagnosis? [/INST] yes, This study presents a novel algorithm for specimen classification in cases of poorly differentiated NSCLC. The source for this answer is PMID: 23207443. </s> |
<s>[INST] Does parenteral nutrition-associated hyperglycemia in non-critically ill inpatients increase the risk of in-hospital mortality ( multicenter study )? [/INST] yes, Hyperglycemia (mean blood glucose level >180 mg/dL) in noncritically ill patients who receive TPN is associated with a higher risk of in-hospital mortality. The source for this answer is PMID: 23223407. </s> |
<s>[INST] Is body composition normal in term infants born to mothers with well-controlled gestational diabetes mellitus? [/INST] yes, In this study, neonatal BF% did not differ by maternal GDM status, and this may be attributed to good maternal glycemic control. The source for this answer is PMID: 23223404. </s> |
<s>[INST] Does u-PA inhibitor amiloride suppress peritoneal metastasis in gastric cancer? [/INST] yes, The findings in our current report provide evidence that selective u-PA inhibitor amiloride has potent effects against peritoneal metastasis in gastric cancer, suggesting its possible therapeutic value for the treatment of gastric cancer. The source for this answer is PMID: 23234499. </s> |
<s>[INST] Does hedgehog signaling display a biphasic expression pattern during intestinal injury and repair? [/INST] yes, Hedgehog signaling pathway displays a biphasic expression pattern during the injury/repair of small intestine. It may play an important regulatory role in intestinal repair. The source for this answer is PMID: 23217885. </s> |
<s>[INST] Does laquinimod prevent inflammation-induced synaptic alterations occurring in experimental autoimmune encephalomyelitis? [/INST] yes, Our data suggest a novel neuroprotective mechanism by which laquinimod might in vivo protect from neuronal damage occurring as a consequence of inflammatory immune-mediated demyelination. The source for this answer is PMID: 23232603. </s> |
<s>[INST] Do stress variables add differential diagnostic information between ischemic and nonischemic cardiomyopathy over myocardial perfusion SPECT imaging? [/INST] yes, Estimated functional capacity and ST depression improve the diagnostic value of stress-rest SPECT to differentiate between ICM and NICM. The source for this answer is PMID: 23211995. </s> |
<s>[INST] Does percutaneous revascularization improve outcomes in patients with prior coronary artery bypass surgery? [/INST] yes, Significantly fewer post-CABG patients received repeat revascularization than all-comers however; PCI was associated with improved mortality in both the diabetic and the nondiabetic patient population. These findings support the practice of attempting revascularization in post-CABG patients, particularly in those with an ACS. The source for this answer is PMID: 23208677. </s> |
<s>[INST] Does low molecular weight heparin inhibit circulating fibrocytes differentiation by modulating neuronal nitric oxide synthase and TGF-β1/Smad pathway? [/INST] yes, These results suggested that LH could exhibit anti-fibrotic effects by inhibiting CFs transdifferentiation, in which the involvement of nNOS/NO and TGF-β/Smad pathway were identified. The source for this answer is PMID: 23207953. </s> |
<s>[INST] Does sertraline exposure lead to small left heart syndrome in adult mice? [/INST] yes, Neonatal sertraline exposure causes long-term changes in cardiac morphology and physiology. We speculate that early-life SSRI exposure impairs cardiomyocyte growth and central serotonin signaling, leading to a small left heart syndrome in adult mice. The source for this answer is PMID: 23232669. </s> |
<s>[INST] Are neuropeptide Y receptors Y1 and Y2 present in neurons and glial cells in rat retinal cells in culture? [/INST] yes, We have clarified the presence of the NPY Y(1) and Y(2) receptors in all different cell types that constitute the retina, which we believe will help open new perspectives for studying the physiology and the potential pathophysiologic function of NPY and its receptors in the retina. The source for this answer is PMID: 23211819. </s> |
<s>[INST] Does only first intravitreal bevacizumab injection achieve statistically significant visual improvement in naïve myopic choroidal neovascularization? [/INST] yes, The use of intravitreal bevacizumab "as needed" is an effective treatment for myopic CNV, but visual gain is statistically significant only after the first injection and decreases in the second year. The source for this answer is PMID: 23204830. </s> |
<s>[INST] Is the maximum standardized uptake value of fluorodeoxyglucose positron emission tomography of the primary tumour a good predictor of pathological nodal involvement in clinical N0 non-small-cell lung cancer? [/INST] yes, Postoperative nodal status was significantly predicted by the SUVmax of FDG-PET of the primary tumour instead of the lymph nodes themselves. The patients with NSCLC in particular who show strong uptake values of SUVmax in the primary tumour could have occult nodal metastases, and may be indicated for a further preoperative modality for an accurate staging. The source for this answer is PMID: 23233074. </s> |
<s>[INST] Does the uraemic toxin phenylacetic acid contribute to inflammation by priming polymorphonuclear leucocytes? [/INST] yes, PAA increases the activation of various PMNL functions and the expression of surface activation markers, while it attenuates PMNL apoptotic cell death. Therefore, PAA may contribute to the inflammatory state and consequently to increased cardiovascular risk in uraemic patients. The source for this answer is PMID: 23229930. </s> |
<s>[INST] Does the shape of the proximal femur influence acetabular wear patterns over time? [/INST] yes, Femoral geometry appears to influence the pattern of acetabular wear occurring over time. The source for this answer is PMID: 23224910. </s> |
<s>[INST] Does magnetic resonance imaging improve 3-month outcome prediction in mild traumatic brain injury? [/INST] yes, In this prospective multicenter observational study, the clinical relevance of abnormal findings on early brain imaging after MTBI is demonstrated. The addition of early CT and MRI markers to a prognostic model based on previously known demographic, clinical, and socioeconomic predictors resulted in a >2-fold increase in the explained variance in 3-month GOS-E. The source for this answer is PMID: 23224915. </s> |
<s>[INST] Do three-dimensional images contribute to the diagnosis of mucous retention cyst in maxillary sinus? [/INST] yes, CBCT scanning detect MRCMS more accurately than panoramic radiography. The source for this answer is PMID: 23229251. </s> |
<s>[INST] Do validation of a French adaptation of the Harvard Trauma Questionnaire among torture survivors from sub-Saharan African countries? [/INST] yes, Results support the reliability and validity of the French version of the HTQ. The source for this answer is PMID: 23233870. </s> |
<s>[INST] Does simple interrupted suturing increase valve performance after aortic valve replacement with a small supra-annular bioprosthesis? [/INST] yes, Simple interrupted sutures provide larger effective orifice areas and reduce the incidence of prosthesis-patient mismatch after aortic valve replacement with a small supra-annular bioprosthesis. This suture technique is preferred in those patients to maximize valve performance. The source for this answer is PMID: 23228405. </s> |
<s>[INST] Does flower extract of Nyctanthes arbor-tristis modulate glutathione level in hydrogen peroxide treated lymphocytes? [/INST] yes, The present findings suggest the protective role of the hydro-alcoholic extracts of the flower of Nyctanthes arbor-tristis against membrane damage induced by H(2)O(2). The results also suggest that the extract might be rich in phytochemicals with antioxidant/radical scavenging potentials, which might find application in antioxidant therapy. The source for this answer is PMID: 23225968. </s> |
<s>[INST] Does electrophysiologic monitoring for placement of laminectomy lead for spinal cord stimulation under general anesthesia? [/INST] yes, With electrophysiologic monitoring and fluoroscopy guidance, placement of SCS laminectomy leads in select patients under general anesthesia may result in appropriate stimulation coverage and pain relief in most. The source for this answer is PMID: 23205816. </s> |
<s>[INST] Does iGF-1 alter the human parietal pleural electrochemical profile by inhibiting ion trans-cellular transportation after interaction with its receptor? [/INST] yes, It is concluded that IGF-1 changes the electrophysiology of the human parietal pleura by hindering the normal ion transportation and therefore the pleural fluid recycling process. This event is achieved after IGF-1 interaction with its receptor which is present in the human pleura. The source for this answer is PMID: 23206730. </s> |
<s>[INST] Does indoleamine 2,3-dioxygenase 1 ( IDO1 ) activity correlate with immune system abnormalities in multiple myeloma? [/INST] yes, These data suggest that IDO1 expression may contribute to immune suppression in patients with MM and possibly other HGF-producing cancers. The source for this answer is PMID: 23232072. </s> |
<s>[INST] Does implementation of a protocol facilitate evidence-based physiotherapy practice in intensive care units? [/INST] yes, Physiotherapy services provided in intensive care units (ICUs) when the decisions of non-specialised therapists are guided by an evidence-based protocol are safe, differ from usual care, and reflect international consensus on current best evidence for physiotherapy in ICUs. Non-specialised therapists can use this protocol to provide evidence-based physiotherapy services to their patients. Future trials are needed to establish whether or not this will improve patient outcome. The source for this answer is PMID: 23219640. </s> |
<s>[INST] Does metabolomics strategy reveal subpopulation of liposarcomas sensitive to gemcitabine treatment? [/INST] yes, Patients with high-grade liposarcoma have poor prognoses and often fail to respond to chemotherapy. This report identifies elevated nucleoside salvage activity in a subset of liposarcomas that are identifiable using noninvasive PET imaging with FAC and that are sensitive to gemcitabine. Thus, we suggest a new treatment paradigm for liposarcoma patients that uses [18F]-FAC-PET in the clinic to delineate gemcitabine responders from nonresponders. The source for this answer is PMID: 23230188. </s> |
<s>[INST] Does severe stroke induce long-lasting alterations of high-mobility group box 1? [/INST] yes, HMGB1 appears to be involved in the postischemic inflammatory response, but it remains unclear whether HMGB1 initiates this response or merely reflects activation of leukocytes by another signal. The source for this answer is PMID: 23204053. </s> |
<s>[INST] Are increased levels of soluble ICAM-1 in chronic obstructive pulmonary disease and resistant smokers related to active smoking? [/INST] yes, The present study confirms an association between sICAM-1 levels and active smoking in a group of COPD and non-COPD active smokers. The source for this answer is PMID: 23227846. </s> |
<s>[INST] Does mineralocorticoid receptor blockade inhibit accelerated atherosclerosis induced by a low sodium diet in apolipoprotein E-deficient mice? [/INST] yes, In E0 mice, Epl inhibited LSD-accelerated atherosclerosis, despite the elevation of renin and aldosterone levels. It is therefore suggested that the atherogenic action of LSD could be mediated, at least in part, by activation of the mineralocorticoid receptor. In addition, eplerenone may have direct anti-inflammatory actions. The source for this answer is PMID: 23223089. </s> |
<s>[INST] Are human skin fibroblast telomeres shortened after ultraviolet irradiation? [/INST] yes, Telomere length and subsequent cell viability may be affected by UVA irradiation. DNA damage caused by UVA irradiation may initiate the photoageing process and telomeres may be a useful new target for attempts to prevent photoageing. The source for this answer is PMID: 23206469. </s> |
<s>[INST] Does significant and serious dehydration affect skeletal muscle cramp threshold frequency? [/INST] no, Significant and serious hypohydration with moderate electrolyte losses does not alter cramp susceptibility when fatigue and exercise intensity are controlled. Neuromuscular control may be more important in the onset of muscle cramps than dehydration or electrolyte losses. The source for this answer is PMID: 23222192. </s> |
<s>[INST] Is lactate dehydrogenase B required for the growth of KRAS-dependent lung adenocarcinomas? [/INST] yes, This study identifies LDHB as a regulator of cell proliferation in a subset of lung adenocarcinoma and may provide a novel therapeutic approach for treating lung cancer. The source for this answer is PMID: 23224736. </s> |
<s>[INST] Does nerve growth factor induced after temporomandibular joint inflammation decelerate chondrocyte differentiation? [/INST] yes, NGF-TrkA signaling in the TMJ provides potentially a means of protection against the development of osteoarthritis by decelerating chondrocyte differentiation. This discovery may lead to the development of novel therapies for osteoarthritis of the TMJ and other joints. The source for this answer is PMID: 23231346. </s> |
<s>[INST] Do oral antigens induce rheumatoid arthritis-like inflammation in a rat model? [/INST] yes, Oral antigen can induce RA-like inflammation in the articular joints under certain environment such as gut epithelial barrier dysfunction. The source for this answer is PMID: 23229722. </s> |
<s>[INST] Does protein tyrosine phosphatase 1B ( PTP1B ) modulate palmitate-induced cytokine production in macrophage cells? [/INST] yes, The data of this study demonstrate that PTP1B negatively regulates palmitate-induced cytokine secretion in macrophages by mechanisms involving the activation of MAPKs and NF-kB pathways. The source for this answer is PMID: 23229720. </s> |
<s>[INST] Is insulin secretion increased in non-diabetic subjects with fasting hypertriglyceridaemia? [/INST] yes, The results of this study show that hypertriglyceridaemia is associated with the increase of the 1st PIS and the 2nd PIS in apparently healthy subjects. The source for this answer is PMID: 23225554. </s> |
<s>[INST] Does the induction of a radiation-induced bystander effect in fish transcend taxonomic group and trophic level? [/INST] yes, These results are the first to show that a radiation- induced bystander effect can transcend taxonomic group and trophic level in fish. This provides further evidence that bystander signals are widespread and conserved and may be transmitted through an ecosystem, as well as between individuals of the same species. The source for this answer is PMID: 23206292. </s> |
<s>[INST] Does aortic pulse wave velocity result depend on which carotid artery is used for the measurements? [/INST] yes, Using right or left carotid artery affects aPWV, as right-side measurements provided higher values. Attention to this side difference and use of the same carotid artery will increase the strength of intervention studies using aPWV as a surrogate endpoint. The source for this answer is PMID: 23221934. </s> |
<s>[INST] Is corneal inflammation inhibited by the LFA-1 antagonist , lifitegrast ( SAR 1118 )? [/INST] yes, As LFA-1-dependent neutrophil recruitment to the corneal stroma can be blocked by topical lifitegrast, this reagent could be used in combination with antibiotics to prevent leukocyte infiltration to the corneal stroma in association with contact-lens wear. The source for this answer is PMID: 23215542. </s> |
<s>[INST] Is helicobacter pylori a risk factor for colonic neoplasms? [/INST] yes, Various forms of gastritis related to H. pylori infection confer an increased risk for colonic neoplasm. In the past, when H. pylori infection was more prevalent, its attributable risk to the occurrence of colorectal neoplasm may have been quite substantial. The source for this answer is PMID: 23208272. </s> |
<s>[INST] Do newborns of preeclamptic women show evidence of sex-specific disparity in fetal growth? [/INST] yes, Fetal growth was more impaired among male versus female preterm infants born to preeclamptic women. Our study underlined the importance of incorporating sex differences in the study of biological mechanisms for immediate- and long-term consequences of suboptimal fetal growth. The source for this answer is PMID: 23217566. </s> |
<s>[INST] Is total and HMW adiponectin independently associated with B-type natriuretic peptide and anemia in chronic hemodialysis patients? [/INST] yes, Anemia and BNP levels had independent influence on the total and HMW adiponectin levels in chronic HD patients. The source for this answer is PMID: 23207119. </s> |
<s>[INST] Does ischemic postconditioning during reperfusion attenuate oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase? [/INST] yes, These findings suggest that IPo attenuates intestinal I/R-induced intestinal injury via AR-mediated oxidative defense and apoptosis suppression; AR inhibition reverses the protective effects of IPo. AR seems to be an innate protective factor in this model of intestinal I/R. The source for this answer is PMID: 23218881. </s> |
<s>[INST] Is autoantibody against WD repeat domain 1 a novel serological biomarker for screening of thyroid neoplasia? [/INST] yes, Anti-WDR1 antibody could be a novel approach for serological screening of PTC and UTC, and could be an efficient and inexpensive biomarker. The source for this answer is PMID: 23215816. </s> |
<s>[INST] Does cecal ligation and puncture-induced murine sepsis cause lung injury? [/INST] no, These data demonstrate that mice predicted to die during sepsis have no significant lung injury. In murine intra-abdominal sepsis, pulmonary injury cannot be considered the etiology of death in the acute phase. The source for this answer is PMID: 23222255. </s> |
<s>[INST] Is medical Exercise Therapy Effective After Arthroscopic Surgery of Degenerative Meniscus of the Knee : A Randomized Controlled Trial? [/INST] yes, For people who have undergone surgery for degenerative meniscus damage, postoperative high repetitive, high dosage medical exercise therapy is an efficient treatment alternative compared to no rehabilitation. The source for this answer is PMID: 23226170. </s> |
<s>[INST] Does heavy alcohol consumption increase the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis? [/INST] yes, Heavy alcohol consumption significantly increased the risk of HCC in HBV-related cirrhotic patients. Elevated baseline serum HBV DNA was a strong risk predictor of HCC and antiviral NUCs therapy reduced the incidence of HCC in cirrhotic patients with HBV infection and alcoholism. The source for this answer is PMID: 23220252. </s> |
<s>[INST] Is low wall shear stress independently associated with the rupture status of middle cerebral artery aneurysms? [/INST] yes, WSS may be the most reliable parameter characterizing the rupture status of MCA aneurysms. The source for this answer is PMID: 23223503. </s> |
<s>[INST] Are clusters of spreading depolarizations associated with disturbed cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage? [/INST] yes, SDs can propagate in nonischemic human brain tissue. Clusters of SDs are related to metabolic changes suggestive of ongoing secondary damage in primarily nonischemic brain tissue. The source for this answer is PMID: 23223504. </s> |
<s>[INST] Is obesity-related chronic kidney disease associated with spleen-derived IL-10? [/INST] yes, We suggest that obesity reduces IL-10 induction from the spleen, and spleen-derived IL-10 may protect against the development of CKD induced by obesity. The source for this answer is PMID: 23229922. </s> |